| Document and Entity Information | Mar. 12, 2024 |
| Cover [Abstract] | |
| Amendment Flag | false |
| Entity Central Index Key | 0001062822 |
| Current Fiscal Year End Date | --12-31 |
| Document Type | 8-K |
| Document Period End Date | Mar. 12, 2024 |
| Entity Registrant Name | Lexicon Pharmaceuticals, Inc. |
| Entity Incorporation State Country Code | DE |
| Entity File Number | 000-30111 |
| Entity Tax Identification Number | 76-0474169 |
| Entity Address, Address Line One | 2445 Technology Forest Blvd. |
| Entity Address, Address Line Two | 11th Floor |
| Entity Address, City or Town | The Woodlands |
| Entity Address, State or Province | TX |
| Entity Address, Postal Zip Code | 77381 |
| City Area Code | (281) |
| Local Phone Number | 863-3000 |
| Security 12b Title | Common stock, par value $0.001 |
| Trading Symbol | LXRX |
| Security Exchange Name | NASDAQ |
| Written Communications | false |
| Soliciting Material | false |
| Pre Commencement Tender Offer | false |
| Pre Commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | false |
