Acer Therapeutics (ACER) 10-K 23 Feb 15 2014 FY Annual report Financial data

Document_and_Entity_Informatio

Document and Entity Information (USD $)	12 Months Ended
	Dec. 31, 2014	Feb. 20, 2015	Jun. 30, 2014
Document And Entity Information [Abstract]
Entity Registrant Name	OPEXA THERAPEUTICS, INC.
Entity Central Index Key	1069308
Document Type	10-K
Document Period End Date	31-Dec-14
Amendment Flag	FALSE
Current Fiscal Year End Date	-19
Is Entity a Well-known Seasoned Issuer?	No
Is Entity a Voluntary Filer?	No
Is Entity's Reporting Status Current?	Yes
Entity Filer Category	Smaller Reporting Company
Entity Public Float			$43,709,741
Entity Common Stock, Shares Outstanding		28,234,751
Document Fiscal Period Focus	FY
Document Fiscal Year Focus	2014

Consolidated_Balance_Sheets

Consolidated Balance Sheets (USD $)	Dec. 31, 2014	Dec. 31, 2013
Current assets:
Cash and cash equivalents	$9,906,373	$23,644,542
Other current assets	758,943	1,122,576
Total current assets	10,665,316	24,767,118
Property & equipment, net of accumulated depreciation of $2,099,389 and $1,718,477, respectively	1,098,104	1,295,024
Other long-term assets	38,939	177,666
Total assets	11,802,359	26,239,808
Current liabilities:
Accounts payable	702,494	696,155
Accrued expenses	1,199,184	1,232,990
Deferred revenue	1,230,746	1,395,348
Total current liabilities	3,132,424	3,324,493
Long term liabilities:
Deferred revenue	1,230,748	2,338,041
Total liabilities	4,363,172	5,662,534
Commitments and contingencies
Stockholders' equity:
Preferred stock, no par value, 10,000,000 shares authorized, none issued and outstanding	0	0
Common stock, $0.01 par value, 100,000,000 shares authorized, 28,234,751 and 27,546,058 shares issued and outstanding	282,348	275,461
Additional paid in capital	148,477,047	146,569,758
Accumulated deficit	-141,320,208	-126,267,945
Total stockholders' equity	7,439,187	20,577,274
Total liabilities and stockholders' equity	$11,802,359	$26,239,808

Consolidated_Balance_Sheets_Pa

Consolidated Balance Sheets (Parenthetical) (USD $)	Dec. 31, 2014	Dec. 31, 2013
Statement of Financial Position [Abstract]
Property & equipment, accumulated depreciation	$2,099,389	$1,718,477
Preferred stock, no par value	$0	$0
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$0.01	$0.01
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	28,234,751	27,546,058
Common stock, shares outstanding	28,234,751	27,546,058

Consolidated_Statements_of_Ope

Consolidated Statements of Operations (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Revenue:
Option Revenue	$1,271,895	$1,266,611
Research and development	12,118,629	9,181,090
General and administrative	3,833,370	3,670,769
Depreciation	387,779	335,597
Loss on disposal of fixed assets	0	2,161
Operating loss	-15,067,883	-11,923,006
Interest income	15,456	14,985
Other income and expense, net	2,147	37,910
Loss on extinguishment of debt	0	-2,518,912
Interest expense	-1,983	-2,267,302
Net loss	($15,052,263)	($16,656,325)
Basic and diluted loss per share	($0.54)	($1.25)
Weighted average shares outstanding	27,821,056	13,332,350

Consolidated_Statements_of_Cha

Consolidated Statements of Changes in Stockholders' Equity (USD $)	Common Stock [Member]	Additional Paid In Capital [Member]	Accumulated Deficit	Total
Beginning Balance, Amount at Dec. 31, 2012	$62,494	$112,432,458	($109,611,620)	$2,883,332
Beginning Balance, Shares at Dec. 31, 2012	6,249,369
Conversion of convertible notes, Shares	2,079,960
Conversion of convertible notes, amount	20,799	4,254,254		4,275,053
Discount related to beneficial conversion feature		141,829		141,829
Discount on warrants attached to debt		195,969		195,969
Shares issued for initial commitment on Lincoln Park $1.5 million share purchase agreement, Shares	975
Shares issued for initial commitment on Lincoln Park $1.5 million share purchase agreement, Amount	10	1,224		1,234
Shares issued for cash, net of offering costs, Shares	19,013,952
Shares issued for cash, net of offering costs, Amount	190,140	28,157,960		28,348,100
Shares issued for accrued interest, Shares	123,231
Shares issued for accrued interest, Amount	1,232	187,311		188,543
Shares issued for restricted stock awards, Shares	78,571
Shares issued for restricted stock awards, amount	786	69,113		69,899
Warrant expense		219,553		219,553
Option expense		910,087		910,087
Net loss			-16,656,325	-16,656,325
Ending Balance, Amount at Dec. 31, 2013	275,461	146,569,758	-126,267,945	20,577,274
Ending Balance, Shares at Dec. 31, 2013	27,546,058
Shares issued for cash, net of offering costs, Shares	518,412
Shares issued for cash, net of offering costs, Amount	5,184	642,991		648,175
Shares issued for services, Shares	1,703	304,400		306,103
Shares issued for services, Amount	170,281
Option expense		959,898		959,898
Net loss			-15,052,263	-15,052,263
Ending Balance, Amount at Dec. 31, 2014	$282,348	$148,477,047	($141,320,208)	$7,439,187
Ending Balance, Shares at Dec. 31, 2014	28,234,751

Consolidated_Statements_of_Cas

Consolidated Statements of Cash Flows (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Cash flows from operating activities
Net loss	($15,052,263)	($16,656,325)
Adjustments to reconcile net loss to net cash used in operating activities
Stock issued for services	306,103	69,899
Amortization of discount on notes payable due to warrants and beneficial conversion feature	0	1,613,354
Loss on extinguishment of debt	0	2,518,912
Depreciation	387,779	335,597
Amortization of debt financing costs	0	125,248
Option and warrant expense	959,898	1,129,640
Loss on disposal of fixed assets	0	2,161
Changes in:
Other current assets	363,633	104,051
Accounts payable	6,339	147,923
Accrued expenses	-33,806	928,549
Other assets	138,727	-177,667
Deferred revenue	-1,271,895	3,733,389
Net cash used in operating activities	-14,195,485	-6,125,269
Cash flows from investing activities
Purchase of property & equipment	-190,859	-259,224
Restricted cash	0	1,000,000
Net cash provided by (used in) investing activities	-190,859	740,776
Cash flows from financing activities
Common stock and warrants sold for cash, net of offering costs	648,175	28,484,878
Proceeds from third party debt	0	550,000
Proceeds from related party debt	0	100,000
Deferred financing and offering costs	0	-147,847
Repayment on related party notes payable	0	-100,000
Repayments on notes payable	0	-450,000
Net cash provided by financing activities	648,175	28,437,031
Net change in cash and cash equivalents	-13,738,169	23,052,538
Cash and cash equivalents at beginning of period	23,644,542	592,004
Cash and cash equivalents at end of period	9,906,373	23,644,542
Cash paid for:
Interest	1,983	19,648
NON-CASH TRANSACTIONS
Issuance of common stock for accrued interest	0	188,543
Conversion of notes payable to common stock	0	4,275,053
Discount on convertible notes relating to:
Warrants	0	195,969
Beneficial conversion feature	0	141,829
Unpaid additions to property and equipment	0	108,516
Shares issued as deferred offering costs	0	1,234
Unpaid offering costs	$0	$136,776

1_BUSINESS_OVERVIEW_AND_SUMMAR

1. BUSINESS OVERVIEW AND SUMMARY OF ACCOUNTING POLICIES	12 Months Ended
	Dec. 31, 2014
Accounting Policies [Abstract]
BUSINESS OVERVIEW AND SUMMARY OF ACCOUNTING POLICIES	Description of Business.  Opexa Therapeutics, Inc. (“Opexa”, “we”, “our”, or “the Company”) was initially incorporated as Sportan United Industries, Inc. (“Sportan”) in Texas in March 1991. In June 2004, PharmaFrontiers Corp. (“PharmaFrontiers”) was acquired by Sportan in a transaction accounted for as a reverse acquisition.  In October 2004, PharmaFrontiers acquired all of the outstanding stock of Opexa Pharmaceuticals, Inc. (“Opexa Pharmaceuticals”), a biopharmaceutical company that previously acquired the exclusive worldwide license from Baylor College of Medicine to an patient specific, autologous T-cell immunotherapy, Tcelna® (formerly known as Tovaxin), for the initial treatment of multiple sclerosis (MS). In June 2006, the Company changed its name to Opexa Therapeutics, Inc. from PharmaFrontiers Corp. and, in January 2007, Opexa Therapeutics, Inc., the parent, merged with its wholly owned subsidiary, Opexa Pharmaceuticals with Opexa Therapeutics, Inc. being the surviving company.
	In September 2012, Opexa initiated a Phase IIb clinical trial of Tcelna in patients with secondary progressive MS (“SPMS”). Previously, in September 2008, the Company completed a Phase IIb clinical study of Tcelna in the relapsing-remitting MS (“RRMS”) indication.
	Opexa operates in a highly regulated and competitive environment. The manufacturing and marketing of pharmaceutical products require approval from, and are subject to, ongoing oversight by the Food and Drug Administration, or FDA, in the United States, by the European Medicines Agency, or EMA, in the E.U. and by comparable agencies in other countries. Obtaining approval for a new therapeutic product is never certain and may take many years and may involve expenditure of substantial resources.  Tcelna is in development stage and Opexa has not applied for a Biologics License Application (BLA) for Tcelna with the FDA nor a similar regulatory licensure in any other country, and thus Tcelna is not approved to be marketed in any country.
	Principals of Consolidation.  The financial statements include the accounts of Opexa and its former wholly-owned subsidiary, Opexa Pharmaceuticals through December 31, 2006. All intercompany accounts and transactions have been eliminated.
	The consolidated financial statements include the accounts of Opexa and its wholly owned subsidiary, Opexa Hong Kong Limited (“Opexa Hong Kong”).  Opexa Hong Kong was formed in the Hong Kong Special Administrative Region during 2012 in order to facilitate potential development collaborations in the pan-Asian region.  Presently, Opexa Hong Kong has not entered into any agreements and has not recognized any revenues as of December 31, 2014. All intercompany transactions and balances between Opexa and Opexa Hong Kong are eliminated in consolidation.
	Use of Estimates in Financial Statement Preparation. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.
	Certain Risks and Concentrations. Opexa is exposed to risks associated with foreign currency transactions insofar as it has used U.S. dollars to fund Opexa Hong Kong’s bank account denominated in Hong Kong dollars.  As the net position of the unhedged Opexa Hong Kong bank account fluctuates, Opexa’s earnings may be negatively affected.  In addition, the reported carrying value of the Company’s Hong Kong dollar-denominated assets and liabilities that remain in Opexa Hong Kong will be affected by fluctuations in the value of the U.S. dollar as compared to the Hong Kong dollar.  Opexa currently does not utilize forward exchange contracts or any type of hedging instruments to hedge foreign exchange risk as Opexa believes that its overall exposure is relatively limited.  As of December 31, 2014, Opexa Hong Kong reported cash and cash equivalents of $10,090 in converted U.S. dollars and does not have any reported liabilities in the consolidated balance sheets.
	Revenue Recognition.  On February 4, 2013, Opexa entered into an Option and License Agreement (the “Merck Serono Agreement”) with Ares Trading SA (“Merck Serono”), a wholly owned subsidiary of Merck Serono S.A.  Pursuant to the terms, Merck Serono has an option to acquire an exclusive, worldwide (excluding Japan) license of the Company’s Tcelna program for the treatment of multiple sclerosis (“MS”).  Tcelna is currently in a Phase IIb clinical trial in patients with Secondary Progressive MS (“SPMS”). The option may be exercised by Merck Serono prior to or upon the Company’s completion of the Phase IIb Trial.
	Opexa received an upfront payment of $5 million for granting the option. If the option is exercised, Merck Serono would pay the Company an upfront license fee of $25 million unless Merck Serono is unable to advance directly into a Phase III clinical trial of Tcelna for SPMS without a further Phase II clinical trial (as determined by Merck Serono), in which event the upfront license fee would be $15 million. After exercising the option, Merck Serono would be solely responsible for funding development, regulatory and commercialization activities for Tcelna in MS, although the Company would retain an option to co-fund certain development in exchange for increased royalty rates.  The Company would also retain rights to Tcelna in Japan, certain rights with respect to the manufacture of Tcelna, and rights outside of MS.
	Opexa recognized revenues from nonrefundable, up-front $5 million option fees related to the Merck Serono Agreement on a straightline basis over the estimated option exercise period.  Opexa is required to make estimates regarding the clinical trial timelines which impact the period over which the option exercise may occur.  Opexa’s estimates regarding the option exercise period were adjusted in 2014 once the enrollments for the Abili-T clinical trial were completed.  This adjustment was made on a prospective basis beginning in the periods in which the change was identified and resulted in a decrease in the amount of revenue we recognized on a quarterly basis from the Merck Serono Agreement.
	Cash and Cash Equivalents. For purposes of the consolidated statements of cash flows, cash equivalents include all highly liquid investments with original maturities of three months or less. The primary objectives for the fixed income investment portfolio are liquidity and safety of principal. Investments are made with the objective of achieving the highest rate of return consistent with these two objectives. Opexa’s investment policy limits investments to certain types of instruments issued by institutions primarily with investment grade credit ratings and places restrictions on maturities and concentration by type and issuer.
	Supplies Inventory. Supplies inventory at December 31, 2013 includes reagents and supplies that will be used to manufacture Tcelna and placebo product in Opexa’s Phase IIb clinical study.  Opexa amortized these prepaid reagents and supplies to research and development costs in the consolidated statements of operations over the period that these supplies were used. The supplies inventory was fully amortized as of December 31, 2014.  Future purchases of reagents and supplies are expensed directly to research and development costs.
	Long-lived Assets. Property and equipment are stated on the basis of historical cost less accumulated depreciation. Depreciation is provided using the straight-line method over the estimated useful lives of the assets. Major renewals and improvements are capitalized, while minor replacements, maintenance and repairs are charged to current operations. Impairment losses are recorded on long-lived assets used in operations when indicators of impairment are present and the undiscounted cash flows estimated to be generated by those assets are less than the assets’ carrying amount.
	Deferred costs.  Opexa incurs costs in connection with a debt or equity offering or in connection with the proceeds pursuant to an execution of a strategic agreement.  These costs are recorded as deferred offering or deferred financing costs in the consolidated balance sheets.  Such costs may consist of legal, accounting, underwriting fees and other related items incurred through the date of the debt or equity offering or the date of the execution of the strategic agreement.  Costs in connection with a debt offering are amortized to interest expense over the term of the note instrument.  Costs in connection with the execution of a strategic agreement in which an initial upfront payment is received are offset to the gain recognized in the consolidated statements of operations. Additional paid in capital includes costs recorded as an offset to proceeds in connection with the completion of an equity offering.
	Income Taxes. Income tax expense is based on reported earnings before income taxes. Deferred income taxes reflect the impact of temporary differences between assets and liabilities recognized for financial reporting purposes and such amounts recognized for tax purposes, and are measured by applying enacted tax rates in effect in years in which the differences are expected to reverse. A valuation allowance is recorded to reduce the net deferred tax asset to zero because it is more likely than not that the deferred tax asset will not be realized. The Company recognizes the effect of income tax positions only if those positions are more likely than not of being sustained upon an examination.
	Stock-Based Compensation. Opexa accounts for share-based awards issued to employees in accordance with FASB ASC 718. Accordingly, employee share-based payment compensation is measured at the grant date, based on the fair value of the award, and is recognized as an expense over the requisite service period (generally the vesting is over a 3-year period). Additionally, share-based awards to non-employees are expensed over the period in which the related services are rendered at their fair value.
	Research and Development. Research and development expenses are expensed in the consolidated statements of operations as incurred in accordance with FASB ASC 730, Research and Development.  Research and development expenses include salaries, related employee expenses, clinical trial expenses, research expenses, consulting fees, and laboratory costs. In instances in which the Company enters into agreements with third parties for research and development activities, Opexa may prepay fees for services at the initiation of the contract. Opexa records the prepayment as a prepaid asset in the consolidated balance sheets and amortizes the asset into research and development expense in the consolidated statements of operations over the period of time the contracted research and development services are performed.  Other types of arrangements with third parties may be fixed fee or fee for service, and may include monthly payments or payments upon completion of milestones or deliverables. Opexa expenses the costs of licenses of patents and the prosecution of patents until the issuance of such patents and the commercialization of related products is reasonably assured. Research and development expense for the years ended December 31, 2014 and 2013 was $12,026,970and $9,181,090, respectively.
	Foreign Currency Translation and Transaction Gains and Losses.  Opexa records foreign currency translation adjustments and transaction gains and losses in accordance with FASB ASC 830, Foreign Currency Matters.  For the Company’s operations that have a functional currency other than the U.S. dollar, gains and losses resulting from the translation of the functional currency into U.S. dollars for financial statement presentation are not included in determining net loss, but are accumulated in the cumulative foreign currency translation adjustment account as a separate component of stockholders’ equity.  Opexa Hong Kong’s functional currency is deemed to be the US Dollar; consequently, Opexa records transaction gains and losses in its consolidated statements of operations related to the recurring measurement and settlement of foreign currency denominated transactions and balances.
	Net Loss per Share.  Basic and diluted net loss per share is calculated based on the net loss attributable to common shareholders divided by the weighted average number of shares outstanding for the period excluding any dilutive effects of options, warrants and unvested share awards.

2_CASH_AND_CASH_EQUIVALENTS

2. CASH AND CASH EQUIVALENTS	12 Months Ended
	Dec. 31, 2014
Cash and Cash Equivalents [Abstract]
CASH AND CASH EQUIVALENTS	As of December 31, 2014, Opexa invested approximately $8.7 million in a savings account. For the year ended December 31, 2014, the savings account recognized an average market yield of 0.10%.  Interest income of $15,431 from the savings account was recognized for the year ended December 31, 2014 in the consolidated statements of operations.
	As of December 31, 2014 and 2013, Opexa invested approximately $24,500 in a money market fund investing exclusively in high-quality, short-term money market instruments consisting of U.S. government obligations and repurchase agreements collateralized by the U.S. Government. While this fund seeks current income while preserving capital and liquidity, the fund is subject to risk, including U.S. government obligations risk, and is not federally insured or guaranteed by or obligations of the Federal Deposit Insurance Corporation or any other agency. For the years ended December 31, 2014 and 2013, the money market fund recognized an average market yield of 0.01%. Interest income of $3 was recognized for the year ended December 31, 2014 in the consolidated statements of operations.

3_OTHER_CURRENT_ASSETS

3. OTHER CURRENT ASSETS	12 Months Ended
	Dec. 31, 2014
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
OTHER CURRENT ASSETS	Other current assets consisted of the following at December 31, 2014 and 2013:
	Description	2014		2013
	Supplies inventory	$	0	$	673,044
	Deferred offering costs		259,989		134,518
	Prepaid expenses		498,954		315,014
		$	758,943	$	1,122,576
	Supplies inventory at December 31, 2013 includes reagents and supplies that will be used to manufacture Tcelna and placebo product in Opexa’s Phase IIb clinical study.  Opexa amortized these prepaid reagents and supplies to research and development costs in the consolidated statements of operations over the period that these supplies were used.
	Deferred offering costs at December 31, 2014 and 2013 include costs incurred from third parties in connection with the implementation of a $1.5 million Purchase Agreement in November 2012 pursuant to which Opexa has the right to sell to Lincoln Park Capital Fund, LLC (“Lincoln Park”) up to $1.5 million in shares of its common stock, subject to certain conditions and limitations.  As of December 31, 2014 and 2013, the remaining costs of $134,518 and $134,518, respectively, in connection with the implementation of the $1.5 million Purchase Agreement remained capitalized and are included in other current assets in the consolidated balance sheets.  Upon the sales of shares of common stock under the $1.5 million Purchase Agreement, the capitalized costs are offset against the proceeds of such sales of shares of common stock.
	As of December 31, 2013, deferred offering costs of $103,636 in connection with the implementation of the $15.0 million Purchase Agreement are capitalized and included in other long term assets in the consolidated balance sheets (see Note 5). As of December 31, 2014, this amount was reclassified to other current assets since the Purchase Agreement will expire in 2015.
	During December 2013, the remaining costs in connection with the implementation of the ATM Agreement were charged to general and administrative expense in the consolidated statements of operations as the Company determined that the ATM Agreement would need to be refreshed with a successor sales agent to the original sales agent. During 2014, deferred offering costs of $27,547, incurred in connection with the successor sales agent, were capitalized with $21,835 remaining unamortized in connection with the ATM Program at December 31, 2014.
	Prepaid expenses at December 31, 2014 and 2013 also include costs incurred from third parties in connection with the Merck Serono Agreement (see Note 1).  As of December 31, 2014, the remaining costs of $38,939 in connection with the Merck Serono Agreement that are expected to be amortized over the upcoming twelve month period are capitalized and included in other current assets in the consolidated balance sheets.  The remaining costs of $38,939 in connection with the Merck Serono Agreement that are expected to be amortized beyond the upcoming twelve month period are capitalized and included in other long term assets in the consolidated balance sheets (see Note 5).

4_PROPERTY_AND_EQUIPMENT

4. PROPERTY AND EQUIPMENT	12 Months Ended
	Dec. 31, 2014
Property, Plant and Equipment [Abstract]
PROPERTY AND EQUIPMENT	Property and equipment consisted of the following at December 31, 2014 and 2013:
	Description	Life	2014			2013
	Computer equipment	3 years	$	168,209		$	121,921
	Office furniture and equipment	5-7 years		247,679			245,297
	Software	3 years		116,022			121,378
	Laboratory equipment	7 years		1,100,559			1,270,858
	Leasehold improvements	10 years		675,672			665,158
	Manufacturing equipment	7 years		889,352			588,889
	Subtotal			3,197,493			3,013,501
	Less: accumulated depreciation			(2,099,389	)		(1,718,477	)
	Property and equipment, net		$	1,098,104		$	1,295,024
	Property and equipment is carried at cost less accumulated depreciation. Depreciation is calculated by the straight-line method over the estimated useful life of three to ten years, depending upon the type of equipment, except for leasehold improvements which are amortized using the straight-line method over the remaining lease term or the life of the asset, whichever is shorter. The cost of repairs and maintenance is charged as an expense to the consolidated statements of operations as incurred. Depreciation expense totaled $387,779 and $335,597 for the years ended December 31, 2014 and 2013, respectively.

5_OTHER_LONG_TERM_ASSETS

5. OTHER LONG TERM ASSETS	12 Months Ended
	Dec. 31, 2014
Text Block [Abstract]
OTHER LONG TERM ASSETS	Other long term assets at December 31, 2013 include deferred offering costs of $103,636 which were incurred from third parties in connection with the implementation of a $15.0 million Purchase Agreement in November 2012 pursuant to which Opexa has the right to sell to Lincoln Park up to $15.0 million in shares of its common stock, subject to certain conditions and limitations. As of December 31, 2014, this amount was reclassified to other current assets since the Purchase Agreement will expire in 2015.
	Other long term assets also include costs incurred from third parties in connection with the Merck Serono Agreement (see Note 1). At December 31, 2014 and December 31, 2013 the unamortized costs that are expected to be amortized beyond the upcoming twelve month period amounted to $38,939 and $74,030, respectively.

6_DEFERRED_REVENUE

6. DEFERRED REVENUE	12 Months Ended
	Dec. 31, 2014
Revenue Recognition [Abstract]
DEFERRED REVENUE	On February 4, 2013, Opexa entered into the Merck Serono Agreement (see Note 1). Opexa received an upfront payment of $5 million for granting the option. As a “stand-alone value” term in the Merck Serono Agreement, the $5 million upfront payment is determined to be a single unit of accounting, and is recognized as revenue on a straight-line basis over the option exercise period based on the expected completion term of the Phase IIb clinical trial in SPMS.  Opexa includes the unrecognized portion of the $5 million as deferred revenue on the consolidated balance sheets.

7_INCOME_TAXES

7. INCOME TAXES	12 Months Ended
	Dec. 31, 2014
Income Tax Disclosure [Abstract]
INCOME TAXES	Opexa uses the liability method, where deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the carrying amounts of assets and liabilities for financial and income tax reporting purposes.
	At December 31, 2014 and 2013, Opexa had approximately $70 million and approximately $68 million of unused net operating losses (NOLs), respectively, available for carry forward to future years.  For tax purposes, Opexa elects to capitalize research & development expenses and amortize them over a 10-year period.  The unused NOLs begin to expire at December 31, 2025. At December 31, 2014 and 2013, capitalized R&D amounted to $25.1 million and $13.9 million, respectively.
	At December 31, 2014 and 2013, Opexa had a deferred tax asset which is covered by a full valuation allowance due to uncertainty of Opexa’s ability to generate future taxable income necessary to realize the related deferred tax asset consisting of:
	Deferred tax asset resulting from:	31-Dec-14			31-Dec-13
	Net Operating Loss	$	24,531,026		$	23,631,749
	Research and development tax credits		1,778,030			1,228,997
	Capitalized research and development costs		8,803,914			4,886,605
	Subtotal		35,112,970			29,747,351
	Less valuation allowance		(35,112,970	)		(29,747,351	)
	Net deferred tax asset	$	0		$	0
	Opexa’s ability to utilize the NOLs is subject to the rules of Section 382 of the Internal Revenue Code. Section 382 generally restricts the use of NOLs after an “ownership change” (generally defined as a greater than 50% change (by value) in the Company’s equity ownership over a three-year period).  The Section 382 limitation is applied annually and is equal to the value of Opexa’s stock on the date of the ownership change, multiplied by a designated federal long-term tax-exempt rate.

8_CONVERTIBLE_PROMISSORY_NOTES

8. CONVERTIBLE PROMISSORY NOTES	12 Months Ended
	Dec. 31, 2014
Debt Disclosure [Abstract]
CONVERTIBLE PROMISSORY NOTES	On July 25, 2012, Opexa issued a total of $4,085,000 in principal amount of secured convertible promissory notes (the “Notes” or the “July 2012 Notes”) to third parties and related parties (collectively, the “Noteholders”), of which an aggregate of $630,000 was issued to related parties (See Note 9). The Notes were originally scheduled to mature on July 25, 2014 and accrued interest at the rate of 12% per annum, compounded annually. Interest was payable semi-annually on June 30 and December 31 in either cash or registered shares of common stock, at Opexa’s election. The Notes were secured by substantially all of Opexa’s assets and were convertible into a new class of non-voting Series A convertible preferred stock. The Notes could be converted into Series A convertible preferred stock at the option of the investors at a price of $100.00 per share, subject to certain limitations and adjustments. Additionally, Opexa could elect to convert the Notes into Series A convertible preferred stock if (i) Opexa’s common stock closed at or above $10.00 per share for 20 consecutive trading days or (ii) Opexa achieved certain additional funding milestones to continue its clinical trial program. These milestones included (x) executing a strategic agreement with a partner or potential partner by which Opexa will receive a minimum of $5 million to partially fund, or an option to partner with Opexa for, its Phase II clinical trial for Tcelna in patients with SPMS and (y) receiving a minimum of $25 million in additional capital (including the Note offering proceeds) from any partner, potential partner or any other source.
	The Series A convertible preferred stock accrued dividends at the rate of 8% per annum, which are cumulative and payable semi-annually on June 30 and December 31 in either cash or registered shares of common stock at Opexa’s election. The Series A convertible preferred stock had a liquidation preference of $100.00 per share, entitling holders to payment from the assets of the Company available for distribution to its shareholders before any payment is made to the holders of the common stock. The Series A convertible preferred stock participated in any dividends or other distributions on shares of common stock (other than dividends payable in shares of common stock) along with the common stock.  As a result of anti-dilution adjustments following the November 2012 sale of shares of Opexa’s common stock, the Series A convertible preferred stock was convertible into shares of the Company’s common stock at a price of $3.12 per share (the floor price), subject to certain limitations and conditions, and up to 1,308,236 shares of common stock were issuable if all 12% convertible secured promissory notes issued in the July 2012 financing and outstanding at December 31, 2012 were converted to Series A convertible preferred stock and such stock is then converted into common stock. Additionally, Opexa could elect to convert the Series A convertible preferred stock into common stock if the Company’s common stock closes at or above $16.00 per share for 20 consecutive trading days. As of December 31, 2013 and 2012, no shares of Series A convertible preferred stock were outstanding.
	As part of the security interest in all of the Company’s assets granted to the Noteholders, $1.0 million of the proceeds was originally maintained in a controlled account .  During the year ended December 31, 2013, the restricted cash was reduced to $0 and the controlled account was terminated.
	The Notes were analyzed at issuance for a beneficial conversion feature and Opexa concluded that a beneficial conversion feature exists. The beneficial conversion feature was measured using the commitment-date stock price and was determined to be $1,497,634, of which $230,969 was attributable to related parties.  During the year ended December 31, 2012, the Company recorded $1,497,634 as a debt discount and this amount was amortized to interest expense in the consolidated statements of operations over the term of the Notes. Opexa also analyzed the Notes for derivative accounting consideration and determined that derivative accounting does not apply.
	In connection with the issuance of the Notes, Opexa also issued Series I warrants to the Noteholders to initially purchase an aggregate of 957,422 shares of Opexa’s common stock at $5.00 per share, subject to certain limitations and adjustments.  The warrants have a five-year term and are exercisable six months from the date of issuance, or January 25, 2013. As a result of anti-dilution adjustments, the number of warrant shares for which the Series I warrants are exercisable increased to an aggregate increase of 1,436,121 shares of Opexa’s common stock at an adjusted exercise price of $2.56 per share, subject to further certain limitations and adjustments. As a result, Opexa accounted for these reset provisions in accordance with FASB ASC 815-40, which requires Opexa to record the warrants as a derivative liability at the grant date and to record changes in fair value relating to the warrants at each subsequent balance sheet date (see Note 13).  Opexa can redeem the warrants at $0.01 per share if its common stock closes at or above $10.00 per share for 20 consecutive trading days.
	The initial fair value of the warrant liabilities of $2,314,635, together with the beneficial conversion feature of $1,497,634 were recognized as a debt discount and were amortized to interest expense in the consolidated statements of operations over the term of the Notes using the effective interest method.  During the year ended December 31, 2012, the amortized debt discount was $104,032 and Opexa recognized $552,978 as a derivative gain in the consolidated statements of operations due to the change in fair value of the liability. The unamortized discount as of December 31, 2012 amounted to $3,708,237.
	In February 2013, three of the third party holders of the Notes elected to convert their principal amounts of $900,000 into shares of the Company’s Series A convertible preferred stock with further immediate conversion into 288,229 shares of the Company’s common stock.
	On September 23, 2013, the Company entered into an amendment to the Notes with certain Noteholders with respect to certain terms relating to conversion of the Notes. Pursuant to the Note amendment, all outstanding Notes were amended such that, in addition to the existing conversion arrangements, the Notes became convertible at the Company’s election directly into shares of common stock (rather than any intermediate conversion to shares of Series A convertible preferred stock), at a conversion price of not less than $1.50 nor more than $2.25, based on the most recent closing market price of the Company’s common stock on the NASDAQ Stock Market at the time of the Company’s election to convert the Notes (including any accrued but unpaid interest through the conversion date) into shares of common stock. Notes in the aggregate principal amount of $3,185,000 were outstanding at the time of the Note amendment.
	On September 24, 2013, the Company converted the principal amount of the Notes and unpaid interest totaling $3,275,053 into an aggregate of 1,714,697 shares of common stock at a conversion price of $1.91, which was the most recent closing market price of the Company’s common stock on the NASDAQ Stock Market when the Company effected such conversion. The Company determined that the conversion of the Notes qualifies as a debt extinguishment since the Notes were converted based on the amended conversion price.  Consequently, the Company recorded a loss on extinguishment of debt of $2,518,912 in the consolidated statements of operations, which represents the difference in the fair value of the shares issued of $3,275,053 and the carrying amount of the Notes (including accrued interest of $98,053) of $756,141 at the date of conversion. The carrying amount of the Notes is net of the unamortized discount and deferred financing costs at the date of conversion amounting to $2,432,681 and $86,231, respectively.
	On January 23, 2013, Opexa closed a private offering consisting of convertible notes (the “January 2013 Notes”) and warrants to purchase shares of common stock for gross proceeds of $650,000 of which $100,000 was from a related party (see Note 9).  The January 2013 Notes were originally scheduled to mature on January 23, 2014 and accrued interest at the rate of 12% per annum, compounded annually.  The January 2013 Notes were convertible into common stock at the option of the investors at a price of $1.30 per share, subject to certain limitations. The principal balance plus accrued interest was payable within five business days of the receipt by Opexa of an aggregate of at least $7.5 million in proceeds from the sale of its equity securities and/or as payments from one or more partners or potential partners in return for granting a license, other rights, or an option to license or otherwise acquire rights with respect to Tcelna.
	The January 2013 Notes were analyzed at issuance for a beneficial conversion feature and Opexa concluded that a beneficial conversion feature existed. The beneficial conversion feature was measured using the commitment-date stock price and was determined to be $141,829 of which $21,820 was attributable to the related party. Opexa also analyzed the Notes for derivative accounting consideration and determined that derivative accounting does not apply.
	In connection with the issuance of the January 2013 Notes, Opexa also issued Series J warrants to purchase an aggregate of 243,750 shares of Opexa’s common stock (see Note 13), subject to certain limitations and adjustments.  The relative fair value of the warrant liability of $195,969, together with the beneficial conversion feature of $141,829, were recognized as a debt discount and were amortized to interest expense during the year ended December 31, 2013 in the consolidated statements of operations over the term of the January 2013 Notes using the effective interest method.
	On February 26, 2013, following the receipt of $3.25 million in gross proceeds during February 2013 from the sale of common stock and Series L warrants to purchase shares of common stock, and following the receipt of the upfront payment of $5 million from Merck Serono on February 20, 2013, Opexa paid principal and interest totaling $567,368 to holders of the January 2013 Notes, of which $100,000 was to a related party, and issued 77,034 shares of common stock to one holder of the January 2013 Notes who elected to convert the principal of $100,000.
	During the year ended December 31, 2013, the debt discount of $337,798 in connection with the January 2013 Notes was fully amortized to interest expense in the consolidated statements of operations.
	The following table provides a summary of the changes in convertible debt – third parties, net of unamortized discount, during the year ended December 31, 2013:
	Balance at December 31, 2012	$	318,658
	January 2013 Notes, face value		550,000
	Discount on beneficial conversion feature of January 2013 Notes at issuance		(120,009	)
	Discount on fair value of Series J warrant liability at issuance		(165,820	)
	Repayment of January 23, 2013 Notes		(450,000	)
	Conversion of January 23, 2013 Notes into common stock		(100,000	)
	Conversion of July 25, 2012 Notes into common stock		(900,000	)
	Conversion of July 25, 2012 Notes into common stock		(2,555,000	)
	Unamortized discount closed to loss on debt extinguishment		1,949,003
	Amortization of debt discount to interest expense through December 31, 2013		1,473,168
	Balance at December 31, 2013	$	—

9_RELATED_PARTY_TRANSACTIONS

9. RELATED PARTY TRANSACTIONS	12 Months Ended
	Dec. 31, 2014
Related Party Transactions [Abstract]
RELATED PARTY TRANSACTIONS	Investors in the July 25, 2012 Note offering included two members of Opexa’s Board of Directors and entities affiliated with a third director. Opexa issued an aggregate of $630,000 in principal amount of Notes to the two directors and an entity for which a third director reports beneficial ownership of Opexa securities. In connection with the issuance of such Notes, Opexa also issued warrants to purchase an aggregate of 221,483 shares of common stock. The fair value of the warrants was $356,969. Opexa also determined the Notes contained a beneficial conversation feature with fair value of $230,969. Opexa recorded a total of $587,939 as debt discount associated with the Notes issued to the related parties and amortized $16,044 as interest expense in the consolidated statements of operations for the year ended December 31, 2012.
	Entities affiliated with related parties were issued Series K warrants to purchase an aggregate of 65,636 shares of common stock in connection with the January 29, 2013 waiver with respect to the July 2012 Notes.
	The Company issued shares of common stock to holders of the July 2012 Notes in payment of accrued interest on July 1, 2013, of which related parties were issued an aggregate of 55,328 shares of common stock.
	On September 24, 2013, the July 2012 Notes held by two members of Opexa’s Board of Directors and an entity affiliated with a third director in an aggregate of $647,813 in principal amount and unpaid interest were converted into an aggregate of 339,170 shares of common stock at a conversion price of $1.91, which was the most recent closing market price of the Company’s common stock on the NASDAQ Stock Market when the Company effected such conversion.
	Investors in the January 2013 Note offering included one member of Opexa’s Board of Directors who was issued a Note with a principal amount of $100,000 (see Note 8).
	The following table provides a summary of the changes in convertible debt – related parties, net of unamortized discount, during 2013:
	Balance at December 31, 2012	$	58,105
	January 2013 Notes, face value		100,000
	Discount on beneficial conversion feature of January 2013 Notes at issuance		(21,820	)
	Discount on fair value of Series J warrant liability at issuance		(30,149	)
	Repayment of January 23, 2013 Notes		(100,000	)
	Conversion of July 25, 2012 Notes into common stock		(630,000	)
	Unamortized debt discount closed to loss on debt extinguishment		483,678
	Amortization of debt discount to interest expense through December 31, 2013		140,186
	Balance at December 31, 2013	$	—

10_COMMITMENTS_AND_CONTINGENCI

10. COMMITMENTS AND CONTINGENCIES	12 Months Ended
	Dec. 31, 2014
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES	In October 2005, Opexa entered into a ten-year lease for its office and research facilities. The facility including the property is leased for a term of ten years with two options for an additional five years each at the then prevailing market rate.  Future minimum lease payments under the non-cancellable operating lease are $118,422 for 2015. Rent expense in the consolidated statements of operations was approximately $136,000 for each of the years ended December 31, 2014 and 2013.

11_SIGNIFICANT_CONTRACTUAL_SER

11. SIGNIFICANT CONTRACTUAL SERVICE AND MILESTONE AGREEMENTS	12 Months Ended
	Dec. 31, 2014
Health Care Organizations [Abstract]
SIGNIFICANT CONTRACTUAL SERVICE AND MILESTONE AGREEMENTS	In February 2012, Opexa entered into an agreement with Pharmaceutical Research Associates, Inc. (“PRA”), a contract research organization, in which PRA will provide Opexa with services related to the design, implementation and management of Opexa’s ongoing Phase IIb clinical trial program in SPMS (the “PRA Agreement”). Payments by Opexa to PRA under the PRA Agreement are based on the achievement of certain time and performance milestones as presented in the PRA Agreement. Total payments to PRA during the years ended December 31, 2014 and 2013, which were charged to research and development expense on the consolidated statements of operations, amounted to $1,557,824 and $1,582,380, respectively. Unless terminated by either party without cause on 60 days prior notice or on shorter notice with cause, the initial term of the PRA Agreement is for four years and automatically renews for successive one year terms.
	Through December 31, 2014, Opexa entered into individual Clinical Trial Agreements with 36 Institutions and 36 principal investigators acting within their employment or agent positions within their clinical institution.  Under the terms of each Clinical Trial Agreement, each of the Investigators will identify and recruit subjects with SPMS meeting certain enrollment requirements and conduct clinical research in conjunction with Opexa’s Phase IIb clinical study, and each of the Institutions will provide appropriate resources and facilities so the Institution’s Investigator can conduct Opexa’s Phase IIb clinical study in a timely and professional manner and according to the terms of the Clinical Trial Agreement. Under the terms of each Clinical Trial Agreement, Opexa paid an upfront cash payment to each Institution for start-up and other costs which were charged directly to expense.  Future payments by Opexa to the Institutions during the term of each Clinical Trial Agreement are based on the achievement of certain performance milestones as presented in each Clinical Trial Agreement. Unless terminated by Opexa without cause with 30 days’ notice, or unless terminated by the Institution, Investigator or Opexa for health or safety reasons, the initial term of the Clinical Trial Agreements with each Institution and Investigator is for the duration of their enrolled subjects in the Phase IIb clinical study.
	In November of 2014, Opexa entered into an agreement with Parexel International, LLC (“PAREXEL”), a contract research organization, in which PAREXEL will provide Opexa Regulatory Services for the conduct of the Neuromyelitis Optica (“NMO”) program.  In addition, three Institutional agreements were executed in 2014, to provide preclinical research activities. Services include identification, collection and shipping of blood samples to Opexa for research purposes.

12_EQUITY

12. EQUITY	12 Months Ended
	Dec. 31, 2014
Equity [Abstract]
EQUITY	Summary information regarding equity related transactions for the years ended December 31, 2013 and December 31, 2014 is as follows:
	During 2013, equity related transactions were as follows:
	●	In January 2013, 125,000 shares of common stock were sold and 975 additional commitment shares were issued to Lincoln Park under the $1.5 million purchase agreement for net proceeds of $142,400.
	●	An aggregate of 365,263 shares of common stock were issued in connection with the conversion of the January 2013 and July 2012 Notes (see Note 8).
	●	In February 2013, Opexa sold an aggregate of 167,618 shares of common stock under the ATM Agreement for gross proceeds of $536,417.
	●	On February 11, 2013, Opexa sold an aggregate of 1,083,334 units in a registered offering, with each unit consisting of one share of common stock and a warrant to purchase half (0.5) a share of common stock, at a price of $3.00 per unit, for gross proceeds of $3,250,002. The shares of common stock and warrants were immediately separable and were issued separately such that no units were issued. The warrants are exercisable immediately upon issuance, have a four-year term and an exercise price of $3.00 per share. A fee of 6.0% of the gross proceeds was paid to the placement agent.
	●	On July 1, 2013, Opexa issued 123,231 shares of common stock to the Noteholders of the July 2012 Notes as payment of accrued interest totaling $188,543 through June 30, 2013.
	●	On August 13, 2013, Opexa sold 12,000,000 shares of common stock in an underwritten public offering at a price of $1.50 per share for gross proceeds of $18,000,000.
	●	In September 2013, exercise of the over-allotment option granted to the underwriters of the August 2013 underwritten public offering resulted in the issuance of an additional 900,000 shares of common stock at a price of $1.50 per share for gross proceeds of $1,350,000.
	●	On September 24, 2013, 1,714,697 shares of common stock were issued in connection with the conversion of the remaining outstanding July 2012 Notes (see Note 8).
	●	On November 8, 2013, 78,571 shares of restricted common stock with an aggregate fair value of $147,713 were issued to certain members of Opexa’s management. Opexa recognized stock based compensation expense of $69,899 and $77,814, related to these shares for the years ended December 31, 2013 and 2014, respectively.
	●	On December 23, 2013, Opexa sold 4,738,000 shares of its common stock, including the full exercise of the over-allotment option granted to the underwriters, at a price of $1.70 per share for gross proceeds of $8,054,600.
	●	For the year ended December 31, 2013, $2,985,319 was netted against additional paid in capital as stock offering costs.
	During 2014, equity related transactions were as follows:
	●	On February 28, 2014, 109,617 shares of restricted common stock with an aggregate fair value of $199,503 were issued to certain members of Opexa’s management and certain members of the board of directors. Opexa recognized stock based compensation expense of $168,412 related to these shares for the year ended December 31, 2014. The restricted shares issued to management vest in full on the earlier of the first anniversary of the grant date or termination of employment without cause following a change of control. The restricted shares issued to members of the board of directors vest in four quarterly increments beginning on March 31, 2014.
	●	On March 19, 2014, 6,000 shares of restricted common stock with an aggregate fair value of $12,000 were issued to a certain member of Opexa’s board of directors. Opexa recognized stock based compensation expense of $9,877 related to these shares for the year ended December 31, 2014. The restricted shares vest in three quarterly increments beginning on June 30, 2014.
	●	In the third quarter of 2014, Opexa settled sales of 518,412 shares of common stock generating gross and net proceeds including amortization of deferred financing costs of $674,126 and $648,175, respectively, which were issued pursuant to the ATM.
	●	In the fourth quarter of 2014, Opexa issued 54,664 shares of restricted stock with an aggregate fair market value of $50,000 in partial consideration for the performance of services rendered by a consultant pursuant to a consulting agreement dated October 21, 2014.

13_OPTIONS_AND_WARRANTS

13. OPTIONS AND WARRANTS	12 Months Ended
	Dec. 31, 2014
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
OPTIONS AND WARRANTS	The Board initially adopted the Opexa Therapeutics, Inc. 2010 Stock Incentive Plan on September 2, 2010 for the granting of equity incentive awards to employees, directors and consultants of Opexa, and the Plan was initially approved by the Company’s shareholders on October 19, 2010. On September 25, 2013, the Board approved the Amended and Restated 2010 Stock Incentive Plan (“the 2010 Plan”), and the Company’s shareholders approved the amended 2010 Plan on November 8, 2013, in order to (i) increase the number of shares of common stock reserved for issuance by 3,000,000 shares and (ii) reset the number of stock-based awards issuable to a participant in any calendar year to align with the increase in the shares reserved. The 2010 Plan is the successor to and continuation of Opexa’s June 2004 Compensatory Stock Option Plan (the “2004 Plan”). The 2004 Plan reserved a maximum of 575,000 shares of common stock for issuance pursuant to incentive stock options and nonqualified stock options granted to employees, directors and consultants. Awards were made as either incentive stock options or nonqualified stock options, with the Board having discretion to determine the number, term, exercise price and vesting of grants made under the 2004 Plan. All outstanding equity awards granted under the 2004 Plan continue to be subject to the terms and conditions as set forth in the agreements evidencing such stock awards and the terms of the 2004 Plan, but no additional awards will be granted under the 2004 Plan subsequent to approval of the 2010 Plan.  The 2010 Plan reserves a maximum of 3,625,000 shares of common stock for issuance plus the number of shares subject to stock options outstanding under the 2004 Plan that are forfeited or terminate prior to exercise and would otherwise be returned to the share reserves under the 2004 Plan and any reserved shares not issued or subject to outstanding grants, up to a maximum of 513,220 shares.  The 2010 Plan provides for the grant of incentive stock options or nonqualified stock options, as well as restricted stock, stock appreciation rights, restricted stock units and performance awards that may be settled in cash, stock or other property. The Board of Directors or Compensation Committee, as applicable, administers the 2010 Plan and has discretion to determine the recipients, the number and types of stock awards to be granted and the terms and conditions of the stock awards, including the period of their exercisability and vesting. Subject to a limitation on repricing without shareholder approval, the Board or Compensation Committee, as applicable, may also determine the exercise price of options granted under the 2010 Plan.
	Employee Options:
	During 2013, options to purchase an aggregate of 338,500 shares were granted to employees, at exercise prices ranging from $1.45 to $2.34. These options have terms of ten years and have a vesting schedule of three years. Fair value of $659,601 was calculated using the Black-Scholes option-pricing model.  Variables used in the Black-Scholes option-pricing model for these options include (1) discount rate range of 1.73% and 2.78%, (2) expected term of 5.25 to 6 years, (3) expected volatility range of 191.83% and 203.69% and (4) zero expected dividends.
	During 2013, options to purchase 78,171 shares were forfeited and cancelled.
	Opexa recorded $766,875 stock-based compensation expense to management and employees during 2013, which included the related expense for the options that are expected to vest based on achievement of their related performance conditions. Unamortized stock compensation expense as of December 31, 2013 amounted to $894,821.
	During 2014, performance-based options to purchase an aggregate of 510,125 shares at an exercise price of $1.82 were granted to senior management. These options have a term of ten years and vest 100% upon the earlier of achievement of a performance-based, strategic milestone objective or termination of employment without cause following a change of control. Fair value of $918,554 was calculated using the Black-Scholes option-pricing model.  Variables used in the Black-Scholes option-pricing model for these options include (1) discount rate of 2.65%, (2) expected term of 10 years, (3) expected volatility of 172.33% and (4) zero expected dividends.
	During 2014, incentive based options to purchase an aggregate of 772,875 shares were granted to employees, at exercise prices ranging from $0.86 to $1.82. These options have terms of ten years and have a vesting schedule of four years. Fair value of $1,324,070 was calculated using the Black-Scholes option-pricing model.  Variables used in the Black-Scholes option-pricing model for these options include (1) discount rate range of 2.26 to 2.79%, (2) expected term of 6.25 years, (3) expected volatility range of 176.37% to 315.10% and (4) zero expected dividends.
	During 2014, options to purchase 104,886 shares were forfeited and cancelled.
	Opexa recorded $748,697 stock-based compensation expense to management and employees during 2014, which included the related expense for the options that are expected to vest based on achievement of their related performance conditions. Unamortized stock compensation expense as of December 31, 2014 amounted to $2,239,522.
	Non-Employee Options:
	During 2013, options to purchase an aggregate of 88,572 shares were granted to directors for service on Opexa’s Board at an exercise price of $1.75. Options to purchase an aggregate of 20,000 shares have terms of 10 years, with 50% of the shares vesting immediately and 50% vesting one year from the date of grant. Options to purchase the remaining 68,572 shares will expire on the earlier of 10 years or a change in control of the Company, with 50% of the shares vesting immediately and 50% vesting on December 31, 2013. Fair value of $151,867 was calculated using the Black-Scholes option-pricing model. Variables used in the Black-Scholes option-pricing model for these options include (1) discount rate of 1.73%, (2) expected term of 5.25 years, (3) expected volatility of 201.21% and (4) zero expected dividends.
	During 2013, options to purchase 11,072 shares were forfeited and cancelled.
	Opexa recorded $143,212 of stock-based compensation expense to consultants and directors during 2013. Unamortized stock compensation expense as of December 31, 2013 amounted to $4,190.
	During 2014, options to purchase an aggregate of 120,440 shares were granted to directors for service on Opexa’s Board at an exercise price ranging from $1.82 to $2.00. Options to purchase an aggregate of 26,288 shares have terms of 10 years, with 50% of the shares vesting on the grant date and 50% vesting one year from the date of grant. Options to purchase 78,858 shares have terms of 10 years, with 50% of the shares vesting on the grant date and 50% vesting on December 31, 2014. An option to purchase 8,844 shares has a term of 10 years, with quarterly vesting ending on December 31, 2014.   An option to purchase the remaining 6,450 shares has a term of 10 years, with 33.3% vesting quarterly ending on December 31, 2014.  Fair value of $211,097 was calculated using the Black-Scholes option-pricing model. Variables used in the Black-Scholes option-pricing model for these options include (1) discount rate range of 2.65% to 2.77%, (2) expected term of 5.25 years, (3) expected volatility range of 155% to 157% and (4) zero expected dividends.
	During 2014, options to purchase 37,750 shares were forfeited and cancelled.
	Opexa recorded $211,201 of stock-based compensation expense to consultants and directors during 2014. Unamortized stock compensation expense as of December 31, 2014 amounted to $4,086.
	Broker and Investor Warrants:
	In connection with Opexa’s July 25, 2012 private offering of the July 2012 Notes (see Note 8), Opexa issued warrants to the holders of the July 2012 Notes to purchase an aggregate of 1,436,121 shares of common stock at a current adjusted exercise price of $2.56 per share, subject to certain limitations and adjustments. These warrants have a term of five years and are initially exercisable on January 25, 2013.
	During 2013, warrants to purchase 1,482,892 shares were forfeited.  During 2014, warrants to purchase 22,312 shares were forfeited.
	In connection with Opexa’s January 23, 2013 private offering of the January 2013 Notes (see Note 8), Opexa issued warrants to the holders of the January 2013 Notes to purchase an aggregate of 243,750 shares of common stock at an exercise price of $1.24 per share, subject to certain limitations and adjustments. These warrants have a term of five years and were immediately exercisable. The estimated relative fair value of the investor warrants was $195,969 and was calculated using the Black-Scholes valuation model. The following assumptions were used: (1) no expected dividends, (2) risk free interest rate of 0.76%, (3) expected volatility of 191% and (4) expected life of five years. Opexa can redeem the warrants at $0.01 per share if the Company’s common stock closes at or above $10.00 per share for 20 consecutive trading days.
	Pursuant to a waiver executed by the holders of in excess of two-thirds (66-2/3%) of the principal amount of the outstanding July 2012 Notes and accepted by Opexa, the amount of the cash subject to a deposit control agreement was reduced to $500,000 during January 2013. In exchange for such waiver, the Company issued warrants to the holders of the July 2012 Notes to purchase an aggregate of 187,500 shares of common stock at an exercise price of $1.21 per share, subject to certain limitations and adjustments. The warrants have a term of five years and were immediately exercisable. The estimated fair value of the warrants was $219,553 and was calculated using the Black-Scholes valuation model. The following assumptions were used: (1) no expected dividends, (2) risk free interest rate of 0.90%, (3) expected volatility of 191% and (4) expected life of five years.  Opexa can redeem the warrants at $0.01 per underlying share of common stock if the common stock closes at or above $10.00 per share for 20 consecutive trading days.  The fair value of the warrants was recognized as additional interest expense during the year ended December 31, 2013.
	In connection with Opexa’s February 2013 registered offering (See Note 12), Opexa issued warrants to the investors to purchase an aggregate of 541,668 shares of common stock at an exercise price of $3.00 per share, subject to certain limitations and adjustments. These warrants have a term of four years and were immediately exercisable.
	At December 31, 2013, the aggregate intrinsic value of the outstanding options and warrants was $49,851 and $255,750, respectively.  At December 31, 2014, the aggregate intrinsic value of the outstanding options and warrants was $0 and $0 respectively.
	Summary information regarding options and warrants for the years ended December 31, 2013 and 2014 are as follows:
		Options				Weighted Average			Warrants			Weighted Average
						Exercise						Exercise
						Price						Price
	Outstanding at December 31, 2012		824,620			$	5.54			3,579,087		$	5.64
	Year ended December 31, 2013:
	Granted		427,072				1.94			972,918			2.21
	Exercised		—				—			—			—
	Forfeited and canceled		(89,243	)			4.55			(1,482,892	)		6.54
	Outstanding at December 31, 2013		1,162,449			$	4.3			3,069,113		$	4.12
	Granted		1,403,440				1.78			—			—
	Exercised		—				—			—			—
	Forfeited and canceled		(142,636	)			2.98			(22,312	)		10
	Outstanding at December 31, 2014		2,423,253			$	2.92			3,046,801		$	4.08
	Summary of options outstanding and exercisable as of December 31, 2014 is as follows:
	Range of Exercise		Weighted Average		Number of Options			Number of Options
	Prices		Remaining Contractual		Outstanding			Exercisable
			Life (years)
	$ 0.86 to $ 4.99		7.7		2,241,808			725,523
	5.00 to 9.99		0.3		136,575			136,575
	10.00 to 39.20		0.03		44,870			44,870
	$ 0.86 to $ 39.20		8.04		2,423,253			906,968
	Summary of warrants outstanding and exercisable as of December 31, 2014 is as follows:
	Range of Exercise		Weighted Average		Number of Warrants			Number of Warrants
	Prices		Remaining Contractual		Outstanding			Exercisable
			Life (years)
	$ 1.21 to $ 4.99		2.02		2,409,033			2,409,033
	5.00 to 10.44		0.19		637,768			637,768
	$ 1.21 to $ 10.44		2.21		3,046,801			3,046,801

14_LICENSES_AND_GAIN_ON_EXTING

14. LICENSES AND GAIN ON EXTINGUISHMENT OF LIABILITY	12 Months Ended
	Dec. 31, 2014
Text Block [Abstract]
LICENSES AND GAIN ON EXTINGUISHMENT OF LIABILITY	Stem Cell Technology Agreement
	In August 2009, Opexa entered into an exclusive agreement with Novartis for the further development of its stem cell technology. This technology, which has generated preliminary data, was in early preclinical development. Under the terms of the agreement, Novartis acquired the stem cell technology from Opexa and Novartis had full responsibility for funding and carrying out all research, development and commercialization activities. Opexa received an upfront cash payment of $3 million at the time the agreement was entered into and subsequently received $0.5 million as a technology transfer milestone fee.
	In November 2011, Opexa re-acquired the stem cell assets from Novartis in consideration for releasing Novartis with respect to any further payment obligations owed to Opexa by Novartis  In connection with the re-acquisition of the stem cell assets, a related license agreement with the University of Chicago was re-assigned to Opexa. Opexa and the University of Chicago entered into a Fourth Amended and Restated License Agreement in connection with such assignment to Opexa.
	On August 12, 2014, we provided notice to the University of Chicago of our election to discontinue further prosecution of certain patents relating to the proprietary adult stem cell technology that we licensed from the University of Chicago pursuant to the Fourth Amended and Restated License Agreement dated November 2, 2011. Pursuant to the termination notice, we exercised our contractual option to return the licensed patent rights back to the University of Chicago and terminate the Fourth Amended and Restated License Agreement effective November 10, 2014 in accordance with the terms thereof.

1_BUSINESS_OVERVIEW_AND_SUMMAR1

1. BUSINESS OVERVIEW AND SUMMARY OF ACCOUNTING POLICIES (Policies)	12 Months Ended
	Dec. 31, 2014
Accounting Policies [Abstract]
Description of Business	Description of Business.  Opexa Therapeutics, Inc. (“Opexa”, “we”, “our”, or “the Company”) was initially incorporated as Sportan United Industries, Inc. (“Sportan”) in Texas in March 1991. In June 2004, PharmaFrontiers Corp. (“PharmaFrontiers”) was acquired by Sportan in a transaction accounted for as a reverse acquisition.  In October 2004, PharmaFrontiers acquired all of the outstanding stock of Opexa Pharmaceuticals, Inc. (“Opexa Pharmaceuticals”), a biopharmaceutical company that previously acquired the exclusive worldwide license from Baylor College of Medicine to an patient specific, autologous T-cell immunotherapy, Tcelna® (formerly known as Tovaxin), for the initial treatment of multiple sclerosis (MS). In June 2006, the Company changed its name to Opexa Therapeutics, Inc. from PharmaFrontiers Corp. and, in January 2007, Opexa Therapeutics, Inc., the parent, merged with its wholly owned subsidiary, Opexa Pharmaceuticals with Opexa Therapeutics, Inc. being the surviving company.
	In September 2012, Opexa initiated a Phase IIb clinical trial of Tcelna in patients with secondary progressive MS (“SPMS”). Previously, in September 2008, the Company completed a Phase IIb clinical study of Tcelna in the relapsing-remitting MS (“RRMS”) indication.
	Opexa operates in a highly regulated and competitive environment. The manufacturing and marketing of pharmaceutical products require approval from, and are subject to, ongoing oversight by the Food and Drug Administration, or FDA, in the United States, by the European Medicines Agency, or EMA, in the E.U. and by comparable agencies in other countries. Obtaining approval for a new therapeutic product is never certain and may take many years and may involve expenditure of substantial resources.  Tcelna is in development stage and Opexa has not applied for a Biologics License Application (BLA) for Tcelna with the FDA nor a similar regulatory licensure in any other country, and thus Tcelna is not approved to be marketed in any country.
Principals of Consolidation	Principals of Consolidation.  The financial statements include the accounts of Opexa and its former wholly-owned subsidiary, Opexa Pharmaceuticals through December 31, 2006. All intercompany accounts and transactions have been eliminated.
	The consolidated financial statements include the accounts of Opexa and its wholly owned subsidiary, Opexa Hong Kong Limited (“Opexa Hong Kong”).  Opexa Hong Kong was formed in the Hong Kong Special Administrative Region during 2012 in order to facilitate potential development collaborations in the pan-Asian region.  Presently, Opexa Hong Kong has not entered into any agreements and has not recognized any revenues as of December 31, 2014. All intercompany transactions and balances between Opexa and Opexa Hong Kong are eliminated in consolidation.
Use of Estimates in Financial Statement Preparation	Use of Estimates in Financial Statement Preparation. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.
Certain Risks and Concentrations	Certain Risks and Concentrations. Opexa is exposed to risks associated with foreign currency transactions insofar as it has used U.S. dollars to fund Opexa Hong Kong’s bank account denominated in Hong Kong dollars.  As the net position of the unhedged Opexa Hong Kong bank account fluctuates, Opexa’s earnings may be negatively affected.  In addition, the reported carrying value of the Company’s Hong Kong dollar-denominated assets and liabilities that remain in Opexa Hong Kong will be affected by fluctuations in the value of the U.S. dollar as compared to the Hong Kong dollar.  Opexa currently does not utilize forward exchange contracts or any type of hedging instruments to hedge foreign exchange risk as Opexa believes that its overall exposure is relatively limited.  As of December 31, 2014, Opexa Hong Kong reported cash and cash equivalents of $10,090 in converted U.S. dollars and does not have any reported liabilities in the consolidated balance sheets.
Revenue Recognition	Revenue Recognition.  On February 4, 2013, Opexa entered into an Option and License Agreement (the “Merck Serono Agreement”) with Ares Trading SA (“Merck Serono”), a wholly owned subsidiary of Merck Serono S.A.  Pursuant to the terms, Merck Serono has an option to acquire an exclusive, worldwide (excluding Japan) license of the Company’s Tcelna program for the treatment of multiple sclerosis (“MS”).  Tcelna is currently in a Phase IIb clinical trial in patients with Secondary Progressive MS (“SPMS”). The option may be exercised by Merck Serono prior to or upon the Company’s completion of the Phase IIb Trial.
	Opexa received an upfront payment of $5 million for granting the option. If the option is exercised, Merck Serono would pay the Company an upfront license fee of $25 million unless Merck Serono is unable to advance directly into a Phase III clinical trial of Tcelna for SPMS without a further Phase II clinical trial (as determined by Merck Serono), in which event the upfront license fee would be $15 million. After exercising the option, Merck Serono would be solely responsible for funding development, regulatory and commercialization activities for Tcelna in MS, although the Company would retain an option to co-fund certain development in exchange for increased royalty rates.  The Company would also retain rights to Tcelna in Japan, certain rights with respect to the manufacture of Tcelna, and rights outside of MS.
	Opexa recognized revenues from nonrefundable, up-front $5 million option fees related to the Merck Serono Agreement on a straightline basis over the estimated option exercise period.  Opexa is required to make estimates regarding the clinical trial timelines which impact the period over which the option exercise may occur.  Opexa’s estimates regarding the option exercise period were adjusted in 2014 once the enrollments for the Abili-T clinical trial were completed.  This adjustment was made on a prospective basis beginning in the periods in which the change was identified and resulted in a decrease in the amount of revenue we recognized on a quarterly basis from the Merck Serono Agreement.
Cash and Cash Equivalents	Cash and Cash Equivalents. For purposes of the consolidated statements of cash flows, cash equivalents include all highly liquid investments with original maturities of three months or less. The primary objectives for the fixed income investment portfolio are liquidity and safety of principal. Investments are made with the objective of achieving the highest rate of return consistent with these two objectives. Opexa’s investment policy limits investments to certain types of instruments issued by institutions primarily with investment grade credit ratings and places restrictions on maturities and concentration by type and issuer.
Supplies Inventory	Supplies Inventory. Supplies inventory at December 31, 2013 includes reagents and supplies that will be used to manufacture Tcelna and placebo product in Opexa’s Phase IIb clinical study.  Opexa amortized these prepaid reagents and supplies to research and development costs in the consolidated statements of operations over the period that these supplies were used. The supplies inventory was fully amortized as of December 31, 2014.  Future purchases of reagents and supplies are expensed directly to research and development costs.
Long-lived Assets	Long-lived Assets. Property and equipment are stated on the basis of historical cost less accumulated depreciation. Depreciation is provided using the straight-line method over the estimated useful lives of the assets. Major renewals and improvements are capitalized, while minor replacements, maintenance and repairs are charged to current operations. Impairment losses are recorded on long-lived assets used in operations when indicators of impairment are present and the undiscounted cash flows estimated to be generated by those assets are less than the assets’ carrying amount.
Deferred costs	Deferred costs.  Opexa incurs costs in connection with a debt or equity offering or in connection with the proceeds pursuant to an execution of a strategic agreement.  These costs are recorded as deferred offering or deferred financing costs in the consolidated balance sheets.  Such costs may consist of legal, accounting, underwriting fees and other related items incurred through the date of the debt or equity offering or the date of the execution of the strategic agreement.  Costs in connection with a debt offering are amortized to interest expense over the term of the note instrument.  Costs in connection with the execution of a strategic agreement in which an initial upfront payment is received are offset to the gain recognized in the consolidated statements of operations. Additional paid in capital includes costs recorded as an offset to proceeds in connection with the completion of an equity offering.
Income Taxes	Income Taxes. Income tax expense is based on reported earnings before income taxes. Deferred income taxes reflect the impact of temporary differences between assets and liabilities recognized for financial reporting purposes and such amounts recognized for tax purposes, and are measured by applying enacted tax rates in effect in years in which the differences are expected to reverse. A valuation allowance is recorded to reduce the net deferred tax asset to zero because it is more likely than not that the deferred tax asset will not be realized. The Company recognizes the effect of income tax positions only if those positions are more likely than not of being sustained upon an examination.
Stock-Based Compensation	Stock-Based Compensation. Opexa accounts for share-based awards issued to employees in accordance with FASB ASC 718. Accordingly, employee share-based payment compensation is measured at the grant date, based on the fair value of the award, and is recognized as an expense over the requisite service period (generally the vesting is over a 3-year period). Additionally, share-based awards to non-employees are expensed over the period in which the related services are rendered at their fair value.
Research and Development	Research and Development. Research and development expenses are expensed in the consolidated statements of operations as incurred in accordance with FASB ASC 730, Research and Development.  Research and development expenses include salaries, related employee expenses, clinical trial expenses, research expenses, consulting fees, and laboratory costs. In instances in which the Company enters into agreements with third parties for research and development activities, Opexa may prepay fees for services at the initiation of the contract. Opexa records the prepayment as a prepaid asset in the consolidated balance sheets and amortizes the asset into research and development expense in the consolidated statements of operations over the period of time the contracted research and development services are performed.  Other types of arrangements with third parties may be fixed fee or fee for service, and may include monthly payments or payments upon completion of milestones or deliverables. Opexa expenses the costs of licenses of patents and the prosecution of patents until the issuance of such patents and the commercialization of related products is reasonably assured. Research and development expense for the years ended December 31, 2014 and 2013 was $12,026,970and $9,181,090, respectively.
Foreign Currency Translation and Transaction Gains and Losses	Foreign Currency Translation and Transaction Gains and Losses.  Opexa records foreign currency translation adjustments and transaction gains and losses in accordance with FASB ASC 830, Foreign Currency Matters.  For the Company’s operations that have a functional currency other than the U.S. dollar, gains and losses resulting from the translation of the functional currency into U.S. dollars for financial statement presentation are not included in determining net loss, but are accumulated in the cumulative foreign currency translation adjustment account as a separate component of stockholders’ equity.  Opexa Hong Kong’s functional currency is deemed to be the US Dollar; consequently, Opexa records transaction gains and losses in its consolidated statements of operations related to the recurring measurement and settlement of foreign currency denominated transactions and balances.
Net Loss per Share	Net Loss per Share.  Basic and diluted net loss per share is calculated based on the net loss attributable to common shareholders divided by the weighted average number of shares outstanding for the period excluding any dilutive effects of options, warrants and unvested share awards.

3_OTHER_CURRENT_ASSETS_Tables

3. OTHER CURRENT ASSETS (Tables)	12 Months Ended
	Dec. 31, 2014
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Other Current Assets	Description	2014		2013
	Supplies inventory	$	0	$	673,044
	Deferred offering costs		259,989		134,518
	Prepaid expenses		498,954		315,014
		$	758,943	$	1,122,576

4_PROPERTY_AND_EQUIPMENT_Table

4. PROPERTY AND EQUIPMENT (Tables)	12 Months Ended
	Dec. 31, 2014
Property, Plant and Equipment [Abstract]
Property and Equipment	Description	Life	2014			2013
	Computer equipment	3 years	$	168,209		$	121,921
	Office furniture and equipment	5-7 years		247,679			245,297
	Software	3 years		116,022			121,378
	Laboratory equipment	7 years		1,100,559			1,270,858
	Leasehold improvements	10 years		675,672			665,158
	Manufacturing equipment	7 years		889,352			588,889
	Subtotal			3,197,493			3,013,501
	Less: accumulated depreciation			(2,099,389	)		(1,718,477	)
	Property and equipment, net		$	1,098,104		$	1,295,024

7_INCOME_TAXES_Tables

7. INCOME TAXES (Tables)	12 Months Ended
	Dec. 31, 2014
Income Taxes Tables
Schedule of deferred tax assets	Deferred tax asset resulting from:	31-Dec-14			31-Dec-13
	Net Operating Loss	$	24,531,026		$	23,631,749
	Research and development tax credits		1,778,030			1,228,997
	Capitalized research and development costs		8,803,914			4,886,605
	Subtotal		35,112,970			29,747,351
	Less valuation allowance		(35,112,970	)		(29,747,351	)
	Net deferred tax asset	$	0		$	0

8_CONVERTIBLE_PROMISSORY_NOTES1

8. CONVERTIBLE PROMISSORY NOTES (Tables)	12 Months Ended
	Dec. 31, 2014
Convertible Promissory Notes Tables
Schedule of convertible debt	Balance at December 31, 2012	$	318,658
	January 2013 Notes, face value		550,000
	Discount on beneficial conversion feature of January 2013 Notes at issuance		(120,009	)
	Discount on fair value of Series J warrant liability at issuance		(165,820	)
	Repayment of January 23, 2013 Notes		(450,000	)
	Conversion of January 23, 2013 Notes into common stock		(100,000	)
	Conversion of July 25, 2012 Notes into common stock		(900,000	)
	Conversion of July 25, 2012 Notes into common stock		(2,555,000	)
	Unamortized discount closed to loss on debt extinguishment		1,949,003
	Amortization of debt discount to interest expense through December 31, 2013		1,473,168
	Balance at December 31, 2013	$	—

9_RELATED_PARTY_TRANSACTIONS_T

9. RELATED PARTY TRANSACTIONS (Tables) (Related Party Transactions [Member])	12 Months Ended
	Dec. 31, 2014
Related Party Transactions [Member]
Summary of Changes in Convertible Debt - Net of Unamortized Discount	Balance at December 31, 2012	$	58,105
	January 2013 Notes, face value		100,000
	Discount on beneficial conversion feature of January 2013 Notes at issuance		(21,820	)
	Discount on fair value of Series J warrant liability at issuance		(30,149	)
	Repayment of January 23, 2013 Notes		(100,000	)
	Conversion of July 25, 2012 Notes into common stock		(630,000	)
	Unamortized debt discount closed to loss on debt extinguishment		483,678
	Amortization of debt discount to interest expense through December 31, 2013		140,186
	Balance at December 31, 2013	$	—

13_OPTIONS_AND_WARRANTS_Tables

13. OPTIONS AND WARRANTS (Tables)	12 Months Ended
	Dec. 31, 2014
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Summary Information Regarding Options and Warrants		Options				Weighted Average			Warrants			Weighted Average
						Exercise						Exercise
						Price						Price
	Outstanding at December 31, 2012		824,620			$	5.54			3,579,087		$	5.64
	Year ended December 31, 2013:
	Granted		427,072				1.94			972,918			2.21
	Exercised		—				—			—			—
	Forfeited and canceled		(89,243	)			4.55			(1,482,892	)		6.54
	Outstanding at December 31, 2013		1,162,449			$	4.3			3,069,113		$	4.12
	Granted		1,403,440				1.78			—			—
	Exercised		—				—			—			—
	Forfeited and canceled		(142,636	)			2.98			(22,312	)		10
	Outstanding at December 31, 2014		2,423,253			$	2.92			3,046,801		$	4.08
Stock Option Activity	Range of Exercise		Weighted Average		Number of Options			Number of Options
	Prices		Remaining Contractual		Outstanding			Exercisable
			Life (years)
	$ 0.86 to $ 4.99		7.7		2,241,808			725,523
	5.00 to 9.99		0.3		136,575			136,575
	10.00 to 39.20		0.03		44,870			44,870
	$ 0.86 to $ 39.20		8.04		2,423,253			906,968
Warrant Activity	Range of Exercise		Weighted Average		Number of Warrants			Number of Warrants
	Prices		Remaining Contractual		Outstanding			Exercisable
			Life (years)
	$ 1.21 to $ 4.99		2.02		2,409,033			2,409,033
	5.00 to 10.44		0.19		637,768			637,768
	$ 1.21 to $ 10.44		2.21		3,046,801			3,046,801

2_CASH_AND_CASH_EQUIVALENTS_De

2. CASH AND CASH EQUIVALENTS (Detail Narratives) (USD $)	12 Months Ended
	Dec. 31, 2014
Cash and Cash Equivalents [Abstract]
Investment in savings account	$8,700,000
Percentage of interest recognized from savings account investment	0.10%
Interest income from savings account investment	15,431
Cash and cash equivalents, money market accounts	24,500
Percentage of interest recognized from money market fund	0.01%
Interest income from money market fund	$3

3_OTHER_CURRENT_ASSETS_Details

3. OTHER CURRENT ASSETS (Details) (USD $)	Dec. 31, 2014	Dec. 31, 2013
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Supplies Inventory	$0	$673,044
Deferred offering costs	259,989	134,518
Prepaid expenses	498,954	315,014
Other current assets	$758,943	$1,122,576

4_PROPERTY_AND_EQUIPMENT_Detai

4. PROPERTY AND EQUIPMENT (Details) (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, gross	$3,197,493	$3,013,501
Less: accumulated depreciation	-2,099,389	-1,718,477
Property and equipment, net	1,098,104	1,295,024
Computer Equipment [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	3 years
Property, plant and equipment, gross	168,209	121,921
Office Furniture And Equipment [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, gross	247,679	245,297
Office Furniture And Equipment [Member] | Maximum [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	7 years
Office Furniture And Equipment [Member] | Minimum [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	5 years
Computer Software Intangible Asset [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	3 years
Property, plant and equipment, gross	116,022	121,378
Laboratory Equipment [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	7 years
Property, plant and equipment, gross	1,100,559	1,270,858
Leasehold Improvements [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	10 years
Property, plant and equipment, gross	675,672	665,158
Manufacturing Equipment [Member]
Property Plant And Equipment Disclosure [Line Items]
Property, plant and equipment, useful life	7 years
Property, plant and equipment, gross	$889,352	$588,889

4_PROPERTY_AND_EQUIPMENT_Detai1

4. PROPERTY AND EQUIPMENT (Detail Narratives) (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Property Plant And Equipment Disclosure [Line Items]
Depreciation expense	$387,779	$335,597

5_OTHER_LONG_TERM_ASSETS_Detai

5. OTHER LONG TERM ASSETS (Details) (USD $)	Dec. 31, 2013
Other Long Term Assets Details
Deferred Offering Costs	$103,636

7_INCOME_TAXES_Details

7. INCOME TAXES (Details) (USD $)	Dec. 31, 2014		Dec. 31, 2013
Deferred tax asset resulting from:
Net Operating Loss	$24,531,026		$23,631,749
Research and development tax credits	1,778,030	[1]	1,228,997	[1]
Capitalized research and development costs	8,803,914		4,886,605
Subtotal	35,112,970		29,747,351
Less valuation allowance	-35,112,970		-29,747,351
Net deferred tax asset	$0		$0
[1]	Opexa elects to capitalize research & development expenses and amortize them over a 10-year period.

7_INCOME_TAXES_Detail_Narrativ

7. INCOME TAXES (Detail Narratives) (USD $)	12 Months Ended
	Dec. 31, 2014		Dec. 31, 2013
Income Tax Disclosure [Abstract]
Unused net operating losses	$70,000,000		$68,000,000
Research and development tax credits	$1,778,030	[1]	$1,228,997	[1]
Net operating losses begin to expire	31-Dec-25
[1]	Opexa elects to capitalize research & development expenses and amortize them over a 10-year period.

8_CONVERTIBLE_PROMISSORY_NOTES2

8. CONVERTIBLE PROMISSORY NOTES (Details) (USD $)	12 Months Ended
	Dec. 31, 2013
Balance at beginning of period	$318,658
January 2013 Notes, face value	550,000
Discount on beneficial conversion feature of January 2013 Notes at issuance	-120,009
Discount on fair value of Series J warrant liability at issuance	-165,820
Repayment of January 23, 2013 Notes	-450,000
Unamortized discount closed to loss on debt extinguishment	1,949,003
Amortization of debt discount to interest expense through December 31, 2013	1,473,168
Balance at December 31, 2013	0
Conversion 1
Conversion of Notes common stock	-100,000	[1]
Conversion 2
Conversion of Notes common stock	-900,000	[2]
Conversion 3
Conversion of Notes common stock	($2,555,000)	[2]
[1]	Conversion of January 23, 2013 Notes into common stock
[2]	Conversion of July 25, 2012 Notes into common stock

9_RELATED_PARTY_TRANSACTIONS_D

9. RELATED PARTY TRANSACTIONS (Details) (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Debt Instrument [Line Items]
Balance at December 31, 2012	$0	$58,105
January 2013 Notes, face value	0	100,000
Discount on beneficial conversion feature of January 2013 Notes at issuance		-21,820
Discount on fair value of Series J warrant liability at issuance		-30,149
Repayment of January 23, 2013 Notes		-100,000
Conversion of July 25, 2012 Notes into common stock		-630,000
Unamortized debt discount closed to loss on debt extinguishment		483,678
Amortization of debt discount to interest expense through December 31, 2013		140,186
Balance at December 31, 2013		$0

10_COMMITMENTS_AND_CONTINGENCI1

10. COMMITMENTS AND CONTINGENCIES (Details Narrative) (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Commitments And Contingencies Details Narrative
Future minimum lease payments under the non-cancellable operating lease for 2015	$118,422
Rent expense	$136,000	$136,000

13_OPTIONS_AND_WARRANTS_Summar

13. OPTIONS AND WARRANTS - Summary Information Regarding Options and Warrants (Details) (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013
Options
Number of Shares, Outstanding at beginning of period	1,162,449	824,620
Options, Granted	1,403,440	427,072
Options, Exercised	0	0
Options, Forfeited and canceled	-142,636	-89,243
Number of Shares, Outstanding at end of period	2,423,253	1,162,449
Weighted Average Exercise Price, Options
Weighted average exercise price, Outstanding at beginning of period	$4.30	$5.54
Weighted average exercise price options, Granted	$1.78	$1.94
Weighted average exercise price options, Exercised
Weighted average exercise price options, Forfeited and canceled	$2.98	$4.55
Weighted average exercise price, Outstanding at end of period	$2.92	$4.30
Warrant Share [Member]
Warrants
Number of Shares, Outstanding at beginning of period	3,069,113	3,579,087
Warrants, Granted	0	972,918
Warrants, Exercised	0	0
Warrants, Forfeited and canceled	-22,312	-1,482,892
Number of Shares, Outstanding at end of period	3,046,801	3,069,113
Weighted Average Exercise Price, Warrants
Weighted average exercise price, Outstanding at beginning of period	$4.12	$5.64
Weighted average exercise price warrants, Granted		$2.21
Weighted average exercise price warrants, Exercised
Weighted average exercise price warrants, Forfeited and canceled	$10	$6.54
Weighted average exercise price, Outstanding at end of period	$4.08	$4.12

13_OPTIONS_AND_WARRANTS_Summar1

13. OPTIONS AND WARRANTS - Summary of Options Outstanding and Exercisable (Detail) (USD $)	12 Months Ended
	Dec. 31, 2014
Range One [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum	$0.86
Exercise Price Maximum	$4.99
Weighted Average Remaining Contractual Life (years)	7 years 8 months 12 days
Number of Options Outstanding	2,241,808
Number of Options Exercisable	725,523
Range Two [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum	$5
Exercise Price Maximum	$9.99
Weighted Average Remaining Contractual Life (years)	3 months 18 days
Number of Options Outstanding	136,575
Number of Options Exercisable	136,575
Range Three [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum	$10
Exercise Price Maximum	$39.20
Weighted Average Remaining Contractual Life (years)	11 days
Number of Options Outstanding	44,870
Number of Options Exercisable	44,870
Range Four [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum	$0.86
Exercise Price Maximum	$39.20
Weighted Average Remaining Contractual Life (years)	8 years 14 days
Number of Options Outstanding	2,423,253
Number of Options Exercisable	906,968

13_OPTIONS_AND_WARRANTS_Summar2

13. OPTIONS AND WARRANTS - Summary of Warrant Outstanding and Exercisable (Detail) (Warrant Share [Member], USD $)	12 Months Ended
	Dec. 31, 2014
Range Five [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum, warrant	$1.21
Exercise Price Maximum, warrant	$4.99
Weighted Average Remaining Contractual Life (years), warrant	2 years 7 days
Number of warrants Outstanding	2,409,033
Number of warrants Exercisable	2,409,033
Range Six [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum, warrant	$5
Exercise Price Maximum, warrant	$10.44
Weighted Average Remaining Contractual Life (years), warrant	2 months 8 days
Number of warrants Outstanding	637,768
Number of warrants Exercisable	637,768
Range Seven [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Exercise Price Minimum, warrant	$1.21
Exercise Price Maximum, warrant	$10.44
Weighted Average Remaining Contractual Life (years), warrant	2 years 2 months 16 days
Number of warrants Outstanding	3,046,801
Number of warrants Exercisable	3,046,801