(3) | The securities registered hereby consist of 18,064,506 shares of common stock previously registered pursuant to the registrant’s registration statement on Form S-3 (Registration No. 333-230903) filed with the SEC on April 16, 2019 (the “First Prior Registration Statement”). Pursuant to Rule 415(a)(6) under the Securities Act, registration fees for the securities registered pursuant to the First Prior Registration Statement were covered by the registrant’s prior registration statement on Form S-3 (Registration No. 333-210809) filed on April 18, 2016 (the “Second Prior Registration Statement”). Pursuant to Rule 415(a)(6) under the Securities Act, registration fees for the securities registered pursuant to the Second Prior Registration Statement were covered by the registrant’s prior registration statement on Form S-3 (Registration No. 333-188059) filed on April 22, 2013 (the “Third Prior Registration Statement”). Pursuant to Rule 415(a)(6) under the Securities Act, registration fees for the securities registered pursuant to the Third Prior Registration Statement were covered by the registrant’s prior registration statement on Form S-3 (Registration No. 333-178118) filed on November 22, 2011 (the “Fourth Prior Registration Statement”). Pursuant to Rule 415(a)(6) under the Securities Act, registration fees for the securities registered pursuant to the Fourth Prior Registration Statement were covered by the registrant’s prior registration statements on Form S-3, Registration No. 333-155690 for 17,684,400 shares of common stock (the “Fifth Prior Registration Statement”) and Registration No. 333-171606 for 380,106 shares of common stock (the “Sixth Prior Registration Statement”). Pursuant to Rule 415(a)(6) under the Securities Act, the securities registered pursuant to the Fifth Prior Registration Statement consisted of (i) 16,859,003 shares of common stock previously registered on the registrant’s registration statement on Form S-3 (Registration No. 333-93157) with respect to which the registrant previously paid a registration fee of $6,583.76, (ii) 213,385 shares of common stock previously registered on the registrant’s registration statement on Form S-3 (Registration No. 333-31352) with respect to which the registrant previously paid a registration fee of $511.58, (iii) 585,777 shares of common stock previously registered on the registrant’s registration statement on Form S-3 (Registration No. 333-40854) with respect to which the registrant previously paid a registration fee of $1,467.20 and (iv) 26,235 shares of common stock previously registered on the registrant’s registration statement on Form S-3 (Registration No. 333-51946) with respect to which the registrant previously paid a registration fee of $82.00. The securities registered pursuant to the Sixth Prior Registration Statement consisted of 380,106 shares of common stock with respect to which the registrant paid a fee of $798.32. Pursuant to Rule 415(a)(6) and Rule 457(p) under the Securities Act, all of the $9,442.86 registration fee previously paid by the registrant in connection with such securities will continue to be applied to such securities, and the offering of the securities registered under the First Prior Registration Statement will be deemed terminated as of the date of the filing of this prospectus supplement. |