ASX RELEASE
7 August 2013
Novogen Announces Appointment of Chairman of its Medical Advisory
Board
Novogen today announces the appointment of Professor Paul de Souza as
Chairman of its Medical Advisory Board.
The purpose of the Board is to advise the Company on the design and conduct of
its clinical trials. The membership of the Board will be honorary, enabling the
various members also to act as Clinical Trial Investigators where appropriate.
Professor De Souza is the Foundation Professor of Medical Oncology at the
University of Western Sydney, Director of the Translational Cancer Research
Unit of The Ingham Institute of Medical Research, Conjoint Professor in the
Faculty of Medicine of the University of NSW, and Director of the Department of
Medical Oncology at Liverpool Hospital.
Other members of the Board yet to be appointed will comprise experts drawn
from Australia, USA and Europe.
Novogen CEO, Dr Graham Kelly, said today, “Professor de Souza’s appointment is
timely as we now stand on the verge of bringing CS-6 into the clinic. With CS-6
continuing to meet its targets in its current pre-clinical program, we find
ourselves in a position of being able to bring the drug into the clinic earlier than
originally predicted. Professor de Souza’s considerable expertise in translational
research and clinical trial design will be invaluable in guiding the Company
through this next important step.”
“Our goal is to conduct a joint Phase 1a/1b in Australia and Hong Kong in
patients with late-stage cancer with a focus on Temozolomide-resistant
glioblastoma multiforme and carboplatin-refractory ovarian cancer. Naturally
we will be applying to the FDA to conduct clinical studies in the US in 2014, but
the strategy of conducting our inaugural Phase 1 clinical studies in Australia and
Hong Kong affords considerable time and cost savings,” Kelly added.
About Novogen
Novogen Ltd is a biotechnology company whose shares trade on both the
Australian Stock Exchange (symbol ‘NRT’) and NASDAQ (symbol ‘NVGN’). The
Company is based in Sydney, Australia and in Manhattan, USA, and is focused on
the development of novel anti-cancer drugs. The Company’s inaugural drug
candidate is CS-6, with a pipeline of related drugs in development.
About CS-6
CS-6 belongs to a new class of drug candidates that target a mutation concerned
with the bioenergetics of a cell and which Novogen believes to be a fundamental
and key part of carcinogenesis. Inhibition of this mutation provides the potential
to act against all forms of cancer, including both cancer stem cells and their
daughter cells, and against cells with multiple mechanisms of drug resistance.
CS-6 shows broad anti-proliferative and cytotoxic activity against all human
cancer cells that is has been tested against and ovarian cancer stem cells. CS-6
also has been designed deliberately to meet the major known criteria for
crossing the blood-brain barrier, and for that reason is being developed for the
treatment of glioblastoma multiforme, the main form of primary brain cancer.
Further information
Contact Dr Graham Kelly, Chief Executive Officer.
Tel: 61 2 9476 0344
Fax: 61 2 9476 0388
Mobile: (61) 0429 854 390
16-20 Edgeworth David Ave Hornsby NSW 2077 AUSTRALIA
PO Box 2333 Hornsby Westfield NSW 1635 AUSTRALIA
E: Graham.Kelly@novogen.com
Further information is available on the Company’s web site, www.novogen.com