July 13, 2010
VIA EDGARAND FACSIMILE
Mr. Tim Buchmiller, Esq.
Senior Attorney
United States Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Mail Stop 4720
Washington, D.C. 20549
| Re: | Sequenom, Inc. |
| Form S-3 Registration Statement (File No. 333-167061) |
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant hereby requests that the U.S. Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 to become effective at 10:00 a.m. Eastern Time on July 14, 2010 or as soon thereafter as is practicable.
The undersigned registrant hereby acknowledges that: should the Commission or its staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing; the action of the Commission or its staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and the company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.
| Very truly yours, | ||
| SEQUENOM, INC. | ||
| By: | /s/ Paul V. Maier | |
| Paul V. Maier | ||
| Chief Financial Officer | ||