Cytomedix, Inc.
209 Perry Parkway, Suite 7, Gaithersburg, MD 20877
July 1, 2013
Mr. Russell Mancuso
Branch Chief
Division of Corporation Finance
United States Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549
| Re: | Cytomedix, Inc. |
Post-effective amendment to Form S-3 on Form S-1
Filed July 1, 2013
File No. 333-183703
Dear Mr. Mancuso:
In connection with the above referenced filing, the Company acknowledges the following:
| · | should the Commission or the staff, acting pursuant to delegated authority declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing; |
| · | the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filling effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing, and |
| · | the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States. |
| Very truly yours, | |||
| Cytomedix, Inc. | |||
| By: | /s/ Steven A. Shallcross | ||
| Name: Steven A. Shallcross | |||
| Title: Executive VP, CFO | |||
