QuickLinks -- Click here to rapidly navigate through this document
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the use in this Amendment No. 3 to Registration Statement on Form S-1 of our reports dated July 16, 2010, relating to the financial statements and financial statement schedule of Epocrates, Inc., which appear in such Registration Statement. We also consent to the reference to us under the heading "Experts" in such Registration Statement.
/s/PRICEWATERHOUSECOOPERS LLP
San Jose, California
November 16, 2010
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM