GeoPharma (GORX) 8-K Departure of Directors or Principal Officers

Exhibit 99.1

JOSEPH ZAPPALA

Porta Vita

19955 NE 36^th Court

Aventura, Florida 33180

December 3, 2004

Federal Express and Telecopy

Mr. Jugal K. Taneja

Chairman of the Board

GeoPharma, Inc.

6950 Bryan Dairy Road

Largo, Florida 33777

Re: Resignation as Director

Dear Mr. Taneja:

Please be advised that I hereby resign as a Director of GeoPharma, Inc., effective immediately.

Very truly yours,

/s/ JOSEPH ZAPPALA

Joseph Zappala

cc: John A. Schifino, Esq. (telecopy (813) 221-7335)
Tom Rose, Esq. (telecopy (212) 930-9725)