Advaxis (ADXS) 10-Q 6 Jun 17 2017 Q2 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	6 Months Ended
	Apr. 30, 2017	Jun. 02, 2017
Document And Entity Information
Entity Registrant Name	Advaxis, Inc.
Entity Central Index Key	1,100,397
Document Type	10-Q
Document Period End Date	Apr. 30, 2017
Amendment Flag	false
Current Fiscal Year End Date	--10-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		40,462,700
Trading Symbol	ADXS
Document Fiscal Period Focus	Q2
Document Fiscal Year Focus	2,017

Condensed Balance Sheets (Unaud

Condensed Balance Sheets (Unaudited) - USD ($)	Apr. 30, 2017	Oct. 31, 2016
Current Assets:
Cash and Cash Equivalents	$ 30,024,063	$ 112,750,980
Investments - Held-to-Maturity	85,300,215	39,336,548
Interest Receivable	192,298	80,142
Prepaid Expenses	1,035,408	812,830
Income Tax Receivable		2,549,862
Deferred Expenses	5,135,335	4,291,385
Other Receivable	3,000,000
Due from Broker	1,534,365	2,046
Other Current Assets		51,405
Total Current Assets	126,221,684	159,875,198
Property and Equipment (net of accumulated depreciation)	6,566,061	4,389,074
Intangible Assets (net of accumulated amortization)	4,694,269	4,329,121
Deferred Expenses- net of current portion	59,487
Other Assets	353,147	450,667
TOTAL ASSETS	137,894,648	169,044,060
Current Liabilities:
Accounts Payable	9,698,723	1,720,428
Accrued Expenses	6,092,227	10,905,003
Deferred Revenue	14,047,906	15,020,576
Lease Incentive Obligation	40,226	40,226
Common Stock Warrant Liability		20,156
Total Current Liabilities	29,879,082	27,706,389
Deferred Rent	590,093	475,749
Deferred Revenue- net of current portion	15,241,016	21,234,568
Lease Incentive Obligation- net of current portion	305,047	325,160
Total Liabilities	46,015,238	49,741,866
Commitments and Contingencies
Shareholders' Equity:
Preferred Stock, $0.001 par value; 5,000,000 shares authorized; Series B Preferred Stock; 0 shares issued and outstanding at April 30, 2017 and October 31, 2016. Liquidation preference of $0 at April 30, 2017 and October 31, 2016.
Common Stock - $0.001 par value; 65,000,000 shares authorized, 40,396,519 shares issued and outstanding at April 30, 2017 and 40,057,067 shares issued and 40,041,047 shares outstanding at October 31, 2016.	40,397	40,057
Additional Paid-In Capital	337,094,496	327,098,749
Treasury Stock, at cost, 0 shares at April 30, 2017 and 16,020 shares at October 31, 2016.		(129,787)
Accumulated Deficit	(245,255,483)	(207,706,825)
Total Shareholders' Equity	91,879,410	119,302,194
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY	$ 137,894,648	$ 169,044,060

Condensed Balance Sheets (Unau3

Condensed Balance Sheets (Unaudited) (Parenthetical) - USD ($)	Apr. 30, 2017	Oct. 31, 2016
Statement of Financial Position [Abstract]
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Series B Preferred stock, shares issued	0	0
Series B Preferred stock, shares outstanding	0	0
Preferred stock, liquidation preference value	$ 0	$ 0
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	65,000,000	65,000,000
Common stock, shares issued	40,396,519	40,057,067
Common stock, shares outstanding	40,396,519	40,041,047
Treasury Stock, shares	0	16,020

Statements of Operations (Unaud

Statements of Operations (Unaudited) - USD ($)	3 Months Ended		6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016
Income Statement [Abstract]
Revenue	$ 3,425,380		$ 7,216,222	$ 250,000
Operating Expenses:
Research and Development Expenses	16,308,736	8,758,410	29,957,290	21,823,364
General and Administrative Expenses	7,779,698	6,834,824	15,107,507	13,971,647
Total Operating Expenses	24,088,434	15,593,234	45,064,797	35,795,011
Loss from Operations	(20,663,054)	(15,593,234)	(37,848,575)	(35,545,011)
Other Income (Expense):
Interest Income	184,747	70,389	329,884	142,189
Net Changes in Fair Value of Derivative Liabilities	10,652	592	20,156	49,874
Other Income (Expense), Net		(197)	(123)	(201)
Net Loss Before Benefit for Income Taxes	(20,467,655)	(15,522,450)	(37,498,658)	(35,353,149)
Income Tax Expense			50,000	14,236
Net Loss	$ (20,467,655)	$ (15,522,450)	$ (37,548,658)	$ (35,367,385)
Net Loss Per Share, Basic and Diluted	$ (0.51)	$ (0.45)	$ (0.93)	$ (1.04)
Weighted Average Number of Shares Outstanding, Basic and Diluted	40,295,941	34,131,259	40,204,062	33,906,400

Condensed Statements of Cash Fl

Condensed Statements of Cash Flows (Unaudited) - USD ($)	6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016
OPERATING ACTIVITIES
Net loss	$ (37,548,658)	$ (35,367,385)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock compensation	10,324,150	14,361,583
Gain on change in value of warrants and embedded derivative	(20,156)	(49,874)
Loss on disposal of property and equipment	3,187
Impairment of intangible assets	89,881
Employee stock purchase plan	135,202	17,257
Depreciation expense	337,403	95,124
Amortization expense of intangible assets	152,155	118,744
Lease incentive obligation	(20,113)
Amortization of premium on held-to-maturity investments	99,523	164,284
Deferred rent	114,344	175,763
Change in operating assets and liabilities:
Interest receivable	(112,156)	(19,277)
Prepaid expenses	(222,578)	(313,950)
Income tax receivable	2,549,862	1,609,349
Other receivable	(3,000,000)
Other current assets	51,405
Deferred expenses	(903,437)	(2,390,748)
Due from broker	(1,532,319)	7,616
Other assets	97,520	(186,019)
Accounts payable and accrued expenses	2,818,357	5,018,726
Deferred revenue	(6,966,222)
Net cash used in operating activities	(33,552,650)	(16,758,807)
INVESTING ACTIVITIES
Purchases of held-to-maturity investments	(67,215,523)	(7,651,121)
Proceeds from maturities and redemptions on held-to-maturity investments	21,152,333	3,430,000
Purchase of property and equipment	(2,342,515)	(739,275)
Cost of intangible assets	(607,184)	(456,437)
Net cash used in investing activities	(49,012,889)	(5,416,833)
FINANCING ACTIVITIES
Proceeds from exercise of warrants		614,368
Taxes paid related to net share settlement of equity awards	(264,986)	(34,025)
Employee tax withholdings paid on equity awards	(523,513)	(1,393,595)
Tax shares sold to pay for employee tax withholdings on equity awards	627,121	1,351,670
Net cash provided by Financing Activities	(161,378)	538,418
Net decrease in cash and cash equivalents	(82,726,917)	(21,637,222)
Cash and cash equivalents at beginning of period	112,750,980	66,561,683
Cash and cash equivalents at end of period	30,024,063	44,924,461
Supplemental Disclosures of Cash Flow Information
Cash paid for taxes	50,000	50,000
Supplemental Schedule of Non-Cash Investing and Financing Activities
Accrued expenses from consultants settled with common stock	75,000	55,000
Conversion of notes payable into common stock		29,549
Property and equipment included in accounts payable and accrued expenses	$ 175,062

Nature of Operations

Nature of Operations	6 Months Ended
	Apr. 30, 2017
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of Operations	1. NATURE OF OPERATIONS Advaxis, Inc. (“Advaxis” or the “Company”) is a late-stage biotechnology company focused on the discovery, development and commercialization of proprietary Lm Listeria monocytogenes Lm Lm TM Lm Axalimogene filolisbac is our lead Lm ® Axalimogene filolisbac has received United States Food and Drug Administration (“FDA”) orphan drug designation for three HPV-associated cancers: cervical, head and neck, and anal cancer, and has received European Medicines Agency (“EMA”) orphan drug designation for anal cancer. Axalimogene filolisbac has been designated by the FDA as a Fast Track product for adjuvant therapy for high-risk locally advanced cervical cancer patients. It has also been classified as an advanced-therapy medicinal product (“ATMP”) for the treatment of cervical cancer by the European Medicines Agency’s Committee for Advanced Therapies (“CAT”). Axalimogene filolisbac is subject to an agreement with the FDA, under the Special Protocol Assessment (“SPA”) process, for the Phase 3 AIM2CERV trial in patients with high-risk, locally advanced cervical cancer. It is also being evaluated in Company-sponsored trials executed under an Investigational New Drug (“IND”) which include the following: (i) a Phase 1/2 clinical trial alone and in combination with MedImmune, LLC’s (“MedImmune”) investigational anti-PD-L1 immune checkpoint inhibitor, durvalumab (MEDI4736), in patients with previously treated metastatic cervical cancer or patients with HPV-associated head and neck cancer; and (ii) a single arm Phase 2 monotherapy study in patients with metastatic anal cancer. In addition to the Company-sponsored trials, axalimogene filolisbac is also being evaluated in two investigator-initiated clinical trials as follows: neoadjuvant treatment of HPV-positive head and neck cancer (Mount Sinai & Baylor College of Medicine), and locally advanced high risk anal cancer (Brown University). ADXS-PSA is the Company’s Lm ® ADXS-HER2 is the Company’s Lm Lm ADXS-NEO is the Company’s individual Lm The Company has focused its development efforts on establishing a drug development pipeline that incorporates this technology into therapeutic cancer immunotherapies, with clinical trials currently targeting HPV-associated cancers (cervical cancer, head and neck cancer, and anal cancer), prostate cancer, and osteosarcoma. Although no immunotherapies have been commercialized to date, the Company continues to invest in research and development to advance the technology and make it available to patients with many different types of cancer. Pipeline development and the further exploration of the technology for advancement entails risk and expense. The Company anticipates that its ongoing operational costs will increase significantly as it continues conducting and expanding its clinical development programs. In addition to its existing single antigen vectors that target one tumor associated antigen, the Company is actively engaged in the development of new constructs that will address multiple targets that are common to tumor types, as well as mutation-associated epitopes that are specific to an individual patient’s tumor. The Company is also leveraging its Lm Lm Liquidity and Financial Condition The Company’s products are being developed and have not generated significant revenues. As of April 30, 2017, the Company had approximately $115.3 million in cash, cash equivalents and investments on its balance sheet. The Company believes its current cash position is sufficient to fund its business plan approximately through the second quarter of fiscal 2019. The estimate is based on assumptions that may prove to be wrong, and the Company could use available capital resources sooner than currently expected. Because of the numerous risks and uncertainties associated with the development and commercialization of its product candidates, the Company is unable to estimate the amount of increased capital outlays and operating expenses associated with completing the development of its current product candidates. The Company recognizes it may need to raise additional capital in order to continue to execute its business plan. There is no assurance that additional financing will be available when needed or that management will be able to obtain financing on terms acceptable to the Company or whether the Company will become profitable and generate positive operating cash flow. If the Company is unable to raise sufficient additional funds, it will have to scale back its business plan.

Summary of Significant Accounti

Summary of Significant Accounting Policies and Basis of Presentation	6 Months Ended
	Apr. 30, 2017
Accounting Policies [Abstract]
Summary of Significant Accounting Policies and Basis of Presentation	2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND BASIS OF PRESENTATION Basis of Presentation - Unaudited Interim Financial Information The accompanying unaudited interim condensed financial statements and related notes have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) for interim financial information, and in accordance with the rules and regulations of the SEC with respect to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. The unaudited interim condensed financial statements furnished reflect all adjustments (consisting of normal recurring accruals) which are, in the opinion of management, necessary to represent a fair statement of the results for the interim periods presented. Interim results are not necessarily indicative of the results for the full year. These unaudited interim condensed financial statements should be read in conjunction with the financial statements of the Company for the year ended October 31, 2016 and notes thereto contained in the Company’s annual report on Form 10-K for the year ended October 31, 2016, as filed with the SEC on January 9, 2017. The information presented in the accompanying unaudited condensed balance sheet as of October 31, 2016 has been derived from the Company’s October 31, 2016 audited financial statements. Estimates The preparation of financial statements in accordance with U.S. GAAP involves the use of estimates and assumptions that affect the recorded amounts of assets and liabilities as of the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results may differ substantially from these estimates. Significant estimates include the fair value and recoverability of the carrying value of intangible assets (patents and licenses), the fair value of stock options, the fair value of embedded conversion features, warrants and related disclosure of contingent assets and liabilities. On an on-going basis, the Company evaluates its estimates, based on historical experience and on various other assumptions that it believes to be reasonable under the circumstances. Actual results may differ from estimates. Reclassifications Certain amounts in the prior period financial statements have been reclassified to conform to the presentation of the current period financial statements. These reclassifications had no effect on the previously reported net loss. Collaboration Agreements The Company evaluates whether an arrangement is a collaborative arrangement under the Financial Accounting Standards Board (the “FASB”) Accounting Standards Certification (“ASC”) Topic 808, Collaborative Arrangements From time to time, the Company enters into collaborative arrangements for the research and development, manufacture and/or commercialization of products and product candidates. These collaborations generally provide for non-refundable, upfront license fees, research and development and commercial performance milestone payments, cost sharing, royalty payments and/or profit sharing. The Company’s collaboration agreements with third parties are performed on a ‘‘best efforts’’ basis with no guarantee of either technological or commercial success. Revenue Recognition The Company is expected to derive the majority of its revenue from patent licensing and research and development services associated with patent licensing. In general, these revenue arrangements provide for the payment of contractually determined fees in consideration for the grant of certain intellectual property rights for patented technologies owned or controlled by the Company. The intellectual property rights granted may be perpetual in nature, or upon the final milestones being met, or can be granted for a defined, relatively short period of time, with the licensee possessing the right to renew the agreement at the end of each contractual term for an additional minimum upfront payment. The Company recognizes licensing fees when there is persuasive evidence of a licensing arrangement, fees are fixed or determinable, delivery has occurred and collectability is reasonably assured. Revenue associated with nonrefundable upfront license fees under arrangements where the license fees and research and development activities cannot be accounted for as separate units of accounting is deferred and recognized as revenue on a straight-line basis over the expected period of performance. Revenues from the achievement of research and development milestones, if deemed substantive, are recognized as revenue when the milestones are achieved and the milestone payments are due and collectible. If not deemed substantive, the Company recognizes such milestones as revenue on a straight-line basis over the remaining expected performance period under the arrangement. All such recognized revenues are included in collaborative licensing and development revenue in the Company’s statements of operations. Milestones are considered substantive if all of the following conditions are met: (1) the milestone is nonrefundable; (2) achievement of the milestone was not reasonably assured at the inception of the arrangement; (3) substantive effort is involved to achieve the milestone; and (4) the amount of the milestone appears reasonable in relation to the effort expended, and the other milestones in the arrangement and the related risk associated with the achievement of the milestone and any ongoing research and development or other services are priced at fair value. If product development is successful, the Company will recognize revenue from royalties based on licensees’ sales of its products or products using its technologies. Royalties are recognized as earned in accordance with the contract terms when royalties from licensees can be reasonably estimated and collectability is reasonably assured. If royalties cannot be reasonably estimated or collectability of a royalty amount is not reasonably assured, royalties are recognized as revenue when the cash is received. Deferred revenue represents the portion of payments received for which the earnings process has not been completed. Deferred revenue expected to be recognized within the next 12 months is classified as a current liability. An allowance for doubtful accounts is established based on the Company’s best estimate of the amount of probable credit losses in the Company’s existing license fee receivables, using historical experience. The Company reviews its allowance for doubtful accounts periodically. Past due accounts are reviewed individually for collectability. Account balances are charged off against the allowance after all means of collection have been exhausted and the potential for recovery is considered remote. To date, this is yet to occur. Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be cash equivalents. As of April 30, 2017 and October 31, 2016, the Company had approximately $22.3 million and $106.7 million, respectively, in cash equivalents. Concentration of Credit Risk The Company maintains its cash in bank deposit accounts (checking) that at times exceed federally insured limits. Approximately $28.7 million is subject to credit risk at April 30, 2017. However, these cash balances are maintained at creditworthy financial institutions. The Company has not experienced any losses in such accounts and believes it is not exposed to any significant credit risk. Fair Value of Financial Instruments The carrying amounts of financial instruments, including cash, accounts payable and accrued expenses approximated fair value as of the balance sheet date presented, because of the relatively short maturity dates on these instruments. The carrying amounts of the financing arrangements issued approximate fair value as of the balance sheet date presented, because interest rates on these instruments approximate market interest rates after consideration of stated interest rates, anti-dilution protection and associated warrants. Net Loss per Share Basic net income or loss per common share is computed by dividing net income or loss available to common shareholders by the weighted average number of common shares outstanding during the period. Diluted earnings per share give effect to dilutive options, warrants, convertible debt and other potential Common Stock outstanding during the period. In the case of a net loss the impact of the potential Common Stock resulting from warrants, outstanding stock options and convertible debt are not included in the computation of diluted loss per share, as the effect would be anti-dilutive. In the case of net income, the impact of the potential Common Stock resulting from these instruments that have intrinsic value are included in the diluted earnings per share. The table sets forth the number of potential shares of Common Stock that have been excluded from diluted net loss per share. As of April 30, 2017 2016 Warrants 3,110,575 3,110,575 Stock Options 3,893,558 3,351,794 Restricted Stock Units 1,146,435 808,185 Total 8,150,568 7,270,554 Stock Based Compensation The Company has an equity plan which allows for the granting of stock options to its employees, directors and consultants for a fixed number of shares with an exercise price equal to the fair value of the shares at date of grant. The Company measures the cost of services received in exchange for an award of equity instruments based on the fair value of the award. For employees and directors, the fair value of the award is measured on the grant date and for non-employees, the fair value of the award is generally measured based on contractual terms. The fair value amount is then recognized over the requisite service period, usually the vesting period, in both research and development expenses and general and administrative expenses on the statement of operations, depending on the nature of the services provided by the employees or consultants. The process of estimating the fair value of stock-based compensation awards and recognizing stock-based compensation cost over their requisite service period involves significant assumptions and judgments. The Company estimates the fair value of stock option awards on the date of grant using the Black Scholes Model (“BSM”) for the remaining awards, which requires that the Company makes certain assumptions regarding: (i) the expected volatility in the market price of its Common Stock; (ii) dividend yield; (iii) risk-free interest rates; and (iv) the period of time employees are expected to hold the award prior to exercise (referred to as the expected holding period). As a result, if the Company revises its assumptions and estimates, stock-based compensation expense could change materially for future grants. The Company accounts for stock-based compensation using fair value recognition and records stock-based compensation as a charge to earnings net of forfeited awards. As such, the Company recognizes stock-based compensation cost only for those stock-based awards that vest over their requisite service period, based on the vesting provisions of the individual grants. Recent Accounting Pronouncements In May 2014, as part of its ongoing efforts to assist in the convergence of GAAP and International Financial Reporting Standards, the FASB issued ASU 2014-09, Revenue from Contracts with Customers, which is a new standard related to revenue recognition. Under the new standard, recognition of revenue occurs when a customer obtains control of promised services or goods in an amount that reflects the consideration to which the entity expects to receive in exchange for those goods or services. In addition, the standard requires disclosure of the nature, amount, timing, and uncertainty of revenue and cash flows arising from customer contracts. The standard must be adopted using either a full retrospective approach for all periods presented in the period of adoption or a modified retrospective approach. In July 2015, the FASB issued ASU 2015-14, Revenue from Contracts with Customers - Deferral of the Effective Date, which defers the implementation of this new standard to be effective for fiscal years beginning after December 15, 2017. Early adoption is permitted effective January 1, 2017. In March 2016, the FASB issued ASU 2016-08, Principal versus Agent Considerations, which clarifies the implementation guidance on principal versus agent considerations in the new revenue recognition standard pursuant to ASU 2014-09. In April 2016, the FASB issued ASU 2016-10, Identifying Performance Obligations and Licensing, in May 2016, the FASB issued ASU 2016-12, Narrow-Scope Improvements and Practical Expedients, and in December 2016 the FASB issued ASU 2016-20, Technical Corrections and Improvements to Topic 606, Revenue from Contracts with Customers, which amend certain aspects of the new revenue recognition standard pursuant to ASU 2014-09. We are currently evaluating which transition approach we will utilize and the impact of adopting this accounting standard on the Company’s financial statements. In February 2016, the FASB issued ASU 2016-02, Leases (“ASU 2016-02”). The standard amends the existing accounting standards for lease accounting, including requiring lessees to recognize most leases on their balance sheets and making targeted changes to lessor accounting. ASU 2016-02 will be effective beginning in the first quarter of 2019. Early adoption of ASU 2016-02 is permitted. The new leases standard requires a modified retrospective transition approach for all leases existing at, or entered into after, the date of initial application, with an option to use certain transition relief. The Company is currently evaluating the impact of adopting ASU 2016-02 on the Company’s financial statements. In June 2016, the FASB issued ASU 2016-13, “Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments.” The standard significantly changes how entities will measure credit losses for most financial assets and certain other instruments that aren’t measured at fair value through net income. The standard will replace today’s “incurred loss” approach with an “expected loss” model for instruments measured at amortized cost. For available-for-sale debt securities, entities will be required to record allowances rather than reduce the carrying amount, as they do today under the other-than-temporary impairment model. It also simplifies the accounting model for purchased credit-impaired debt securities and loans. This ASU is effective for annual periods beginning after December 15, 2019, and interim periods therein. Early adoption is permitted for annual periods beginning after December 15, 2018, and interim periods therein. This ASU is not expected to have a material impact on the Company’s financial statements. In January 2017, the FASB issued ASU No. 2017-01, “Business Combinations (Topic 805): Clarifying the Definition of a Business.” The amendments in this Update clarify the definition of a business with the objective of adding guidance to assist entities with evaluating whether transactions should be accounted for as acquisitions (or disposals) of businesses. The amendments in this Update provide a screen to determine when a set is not a business. If the screen is not met, it (1) requires that to be considered a business, a set must include, at a minimum, an input and a substantive process that together significantly contribute to the ability to create output and (2) removes the evaluation of whether a market participant could replace the missing elements. This Update is the final version of Proposed ASU 2015-330 Business Combinations (Topic 805) – Clarifying The Definition of a Business, which has been deleted. The amendments in this Update are effective for all entities for annual periods, and interim periods within those annual periods, beginning after December 15, 2017. Early adoption is permitted. This ASU is not expected to have a material impact on the Company’s financial statements. In May 2017, the FASB issued ASU 2017-09, “Compensation—Stock Compensation (Topic 718): Scope of Modification Accounting” to provide clarity and reduce both (1) diversity in practice and (2) cost and complexity when applying the guidance in Topic 718, Compensation—Stock Compensation, to a change to the terms or conditions of a share-based payment award. The amendments in this Update provide guidance about which changes to the terms or conditions of a share-based payment award require an entity to apply modification accounting in Topic 718. This Update is the final version of Proposed ASU 2016-360—Compensation—Stock Compensation (Topic 718)—Scope of Modification Accounting, which has been deleted. The amendments in this Update are effective for all entities for annual periods, and interim periods within those annual periods, beginning after December 15, 2017. Early adoption is permitted. This ASU is not expected to have a material impact on the Company’s financial statements. Management does not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on the accompanying condensed financial statements.

Investments

Investments	6 Months Ended
	Apr. 30, 2017
Schedule of Investments [Abstract]
Investments	3. INVESTMENTS The following table summarizes the Company’s investment securities at amortized cost as of April 30, 2017 and October 31, 2016: April 30, 2017 Amortized cost, as adjusted Gross unrealized holding gains Gross unrealized holding losses Estimated fair value Short-term investments: Certificates of Deposit $ 22,531,815 $ - $ 1 $ 22,531,814 Domestic Governmental Agency Loans 2,666,074 - 1,963 2,664,111 U.S Treasury Notes 60,102,326 - 62,836 60,039,490 Total short-term investment securities $ 85,300,215 $ - $ 64,800 $ 85,235,415 October 31, 2016 Amortized cost, as adjusted Gross unrealized holding gains Gross unrealized holding losses Estimated fair value Short-term investments: Certificates of Deposit $ 10,737,563 $ - $ - $ 10,737,563 Domestic Governmental Agency Loans 2,500,000 - 250 2,499,750 U.S Treasury Notes 26,098,985 2,404 7,556 26,093,833 Total short-term investment securities $ 39,336,548 $ 2,404 $ 7,806 $ 39,331,146 All of the Company’s investments mature within the next 12 months.

Property and Equipment

Property and Equipment	6 Months Ended
	Apr. 30, 2017
Property, Plant and Equipment [Abstract]
Property and Equipment	4. PROPERTY AND EQUIPMENT Property and equipment consists of the following: April 30, 2017 October 31, 2016 Leasehold Improvements $ 2,010,952 $ 1,835,602 Laboratory Equipment 3,423,753 2,038,704 Furniture and Fixtures 693,173 549,025 Computer Equipment 321,777 240,910 Construction in Progress 869,840 151,368 Total Property and Equipment 7,319,495 4,815,609 Accumulated Depreciation and Amortization (753,434 ) (426,535 ) Net Property and Equipment $ 6,566,061 $ 4,389,074 Depreciation expense for the three and six months ended April 30, 2017 and 2016 was $179,823, $337,403, $49,090 and $95,124, respectively.

Intangible Assets

Intangible Assets	6 Months Ended
	Apr. 30, 2017
Goodwill and Intangible Assets Disclosure [Abstract]
Intangible Assets	5. INTANGIBLE ASSETS Pursuant to our license agreement with the University of Pennsylvania (“Penn”), the Company is billed actual patent expenses as they are passed through from Penn and are billed directly from our patent attorney. The following is a summary of intangible assets as of the end of the following fiscal periods: April 30, 2017 October 31, 2016 License $ 776,992 $ 776,992 Patents 5,487,414 4,980,610 Software 25,625 19,625 Total Intangibles 6,290,031 5,777,227 Accumulated Amortization (1,595,762 ) (1,448,106 ) Intangible Assets $ 4,694,269 $ 4,329,121 The expirations of the existing patents range from 2017 to 2037 but the expirations can be extended based on market approval if granted and/or based on existing laws and regulations. Capitalized costs associated with patent applications that are abandoned without future value are charged to expense when the determination is made not to pursue the application. Patent applications having a net book value of $89,881, $89,881, $- and $- were abandoned and were charged to Research and Development Expenses Estimated amortization expense for the next five years is as follows: Year ended October 31, 2017 (Remaining) $ 155,000 2018 311,000 2019 308,000 2020 302,000 2021 302,000

Accrued Expenses

Accrued Expenses	6 Months Ended
	Apr. 30, 2017
Payables and Accruals [Abstract]
Accrued Expenses	6. ACCRUED EXPENSES The following table represents the major components of accrued expenses: April 30, 2017 October 31, 2016 Salaries and Other Compensation $ 1,679,995 $ 2,467,650 Vendors 632,259 2,098,792 Professional Fees 3,779,973 6,338,561 Accrued Expenses $ 6,092,227 $ 10,905,003

Derivative Instruments

Derivative Instruments	6 Months Ended
	Apr. 30, 2017
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Derivative Instruments	7. DERIVATIVE INSTRUMENTS Warrants A summary of changes in warrants for the six months ended April 30, 2017 is as follows: Number of Weighted-Average Warrants Exercise Price Outstanding Warrants at October 31, 2016: 3,110,575 $ 5.04 Issued - - Exercised - - Expired - - Outstanding Warrants at April 30, 2017 3,110,575 $ 5.04 At April 30, 2017 and October 31, 2016, the Company had approximately 3.09 million of its total 3.11 million outstanding warrants classified as equity (equity warrants). At issuance, equity warrants are recorded at their relative fair values, using the Relative Fair Value Method, in the shareholders’ equity section of the balance sheet. The equity warrants can only be settled through the issuance of shares and are not subject to anti-dilution provisions. Warrant Liability At April 30, 2017 and October 31, 2016, the Company had approximately 18,000 of its total approximately 3.11 million outstanding warrants classified as liability warrants (liability warrants). The Company utilizes the BSM to calculate the fair value of these warrants at issuance and at each subsequent reporting date. The liability warrants contain a cash settlement provision in the event of a fundamental transaction (as defined in the Common Stock purchase warrant). Any changes in the fair value of the warrant liability (i.e. the total fair value of all outstanding liability warrants at the balance sheet date) between reporting periods will be reported on the statement of operations. At April 30, 2017 and October 31, 2016, the fair value of the warrant liability was $- and $20,156, respectively. For the three months ended April 30, 2017 and 2016, the Company reported a gain of $10,652 and $592, respectively, due to changes in the fair value of the warrant liability. For the six months ended April 30, 2017 and 2016, the Company reported a gain of $20,156 and $49,874, respectively, due to changes in the fair value of the warrant liability. In determining the fair value of the warrant liability at April 30, 2017 and October 31, 2016, the Company used the following inputs in its BSM: April 30, 2017 October 31, 2016 Exercise Price $ 10.63-18.75 $ 10.63-18.75 Stock Price $ 8.56 $ 8.09 Expected term 0.05-0.26 years 0.55-0.75 years Expected Volatility 34.44%-43.74 % 81.84%-87.09 % Risk Free Interest Rate 0.68%-0.80 % 0.51%-0.66 %

Share Based Compensation

Share Based Compensation	6 Months Ended
	Apr. 30, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Share Based Compensation	8. SHARE BASED COMPENSATION Employment Agreements Management voluntarily purchases restricted stock directly from the Company at market price. The respective stock purchases occur on the last trading day of each month. This voluntary election is outlined in each of Daniel J. O’Connor, Chief Executive Officer and President, Robert G. Petit, Executive Vice President, Chief Scientific Officer, and Sara M. Bonstein, Executive Vice President and Secretary, Chief Financial Officer, (each an “Executive”), employment agreements. The table below reflects the purchases of each Executive: ANNUALIZED Annual Amount For the Six Months Ended April 30, 2017 to be Purchased Gross Purchase Net Purchase Executive $ $ # of shares $ # of shares Daniel J. O’Connor $ 54,547 $ 26,546 2,080 $ 20,008 1,558 Robert G. Petit $ 33,061 $ 16,065 1,811 $ 12,786 1,295 Sara M. Bonstein $ 29,261 $ 14,260 1,158 $ 9,978 845 For the three months ended April 30, 2017, the Company recorded stock compensation expense of $37,308 in the statement of operations for the portion of management salaries voluntarily paid in stock representing 4,395 shares of its Common Stock (3,224 shares on a net basis after employee payroll taxes). For the three months ended April 30, 2016, the Company recorded a similar stock compensation expense of $56,926 in the statement of operations representing 8,028 shares of its Common Stock (5,785 shares on a net basis after employee payroll taxes). For the six months ended April 30, 2017, the Company recorded a similar stock compensation expense of $79,324 in the statement of operations representing 9,711 shares of its Common Stock (7,295 shares on a net basis after employee payroll taxes). For the six months ended April 30, 2016, the Company recorded stock compensation expense of $121,257 in the statement of operations for the portion of management salaries voluntarily paid in stock representing 15,088 shares of its Common Stock (10,732 shares on a net basis after employee payroll taxes). From 2013 to present, in addition to the purchases of Common Stock set forth in the above table, Mr. O’Connor has also purchased an additional 164,909 shares of Common Stock out of his personal funds at the then market price for an aggregate consideration of $689,004. These purchases consisted of the conversion of amounts due to Mr. O’Connor under a promissory note given by Mr. O’Connor to the Company in 2012 of approximately $66,500 for 21,091 shares, 2013 base salary which he elected to receive in Common Stock of approximately $186,555 for 34,752 shares (21,489 on a net basis after employee payroll taxes), 2013 and 2014 cash bonuses voluntarily requested to receive in equity of $214,359 for 62,064 shares (57,990 on a net basis after employee payroll taxes), fiscal 2014 voluntary request to purchase stock directly from the Company at market price purchases of $68,750 for 21,687 shares (15,950 on a net basis after employee payroll taxes), fiscal 2015 voluntary request to purchase stock directly from the Company at market price purchases of $88,840 for 8,482 shares (7,556 on a net basis after employee payroll taxes), and purchases of the Company’s Common Stock in the October 2013 and March 2014 public offerings of 13,500 shares for $54,000 and 3,333 shares for $10,000. Restricted Stock Units (RSUs) A summary of the Company’s RSU activity and related information for the six months ended April 30, 2017 is as follows: Number of Weighted-Average Balance at October 31, 2016: 719,448 $ 10.77 Granted 722,432 $ 8.38 Vested (270,134 ) $ 9.28 Cancelled (25,311 ) $ 9.09 Balance at April 30, 2017 1,146,435 $ 9.65 As of April 30, 2017, there was approximately $9,247,000 of unrecognized compensation cost related to non-vested RSUs, which is expected to be recognized over a remaining weighted average vesting period of approximately 2.19 years. As of April 30, 2017, the aggregate intrinsic value of non-vested RSUs was approximately $9,814,000. Employee Stock Awards Common Stock issued to executives and employees related to vested incentive retention awards, employment inducements and employee excellence awards totaled 155,149 (126,504 shares on a net basis after employee payroll taxes) and 134,239 shares for the three months ended April 30, 2017 and 2016, respectively. Total stock compensation expense associated with these awards for the three months ended April 30, 2017 and 2016 was $1,674,989 and $876,228, respectively. Common Stock issued to executives and employees related to vested incentive retention awards, employment inducements and employee excellence awards totaled 243,809 shares (215,164 shares on a net basis after employee payroll taxes) and 372,368 shares during the six months ended April 30, 2017 and 2016, respectively. Total stock compensation expense associated with these awards for the six months ended April 30, 2017 and 2016 was $2,989,612 and $2,733,304, respectively. Furthermore, non-executive employees were entitled to receive a performance-based year-end cash bonus. Several non-executive employees voluntarily requested to be paid all or a portion of their cash bonus in the Company’s Common Stock instead of cash. During the six months ended April 30, 2016, the total fair value of these equity purchases was $102,022, or 9,150 shares of the Company’s Common Stock. Director Stock Awards Common stock issued to Directors for compensation related to board and committee membership totaled 30,000 and 61,767 shares for the three months ended April 30, 2017 and 2016, respectively. Total stock compensation expense associated with these awards for the three months ended April 30, 2017 and 2016 was $98,315 and $311,205, respectively. Common stock issued to Directors for compensation related to board and committee membership totaled 30,000 and 93,534 shares for the six months ended April 30, 2017 and 2016, respectively. Total stock compensation expense associated with these awards for the six months ended April 30, 2017 and 2016 was $199,943 and $622,410, respectively. Stock Options A summary of changes in the stock option plan for the six months ended April 30, 2017 is as follows: Number of Weighted-Average Options Exercise Price Outstanding at October 31, 2016: 3,351,795 $ 13.31 Granted 556,952 $ 7.71 Exercised - $ - Canceled (4,000 ) $ 3.42 Expired (11,189 ) $ 17.88 Outstanding at April 30, 2017 3,893,558 $ 12.51 Vested and Exercisable at April 30, 2017 2,158,092 $ 13.47 Total compensation cost related to the Company’s outstanding stock options, recognized in the statement of operations for the three months ended April 30, 2017 and 2016, was $3,006,763 and $3,280,517, respectively. For the six months ended April 30, 2017 and 2016, compensation cost related to the Company’s outstanding stock options was $6,190,221 and $9,952,502, respectively. During the six months ended April 30, 2017, 556,952 options were granted with a total grant date fair value of $3,542,215. During the six months ended April 30, 2016, 1,385,000 options were granted with a total grant date fair value of $14,837,970. As of April 30, 2017, there was approximately $14,678,000 of unrecognized compensation cost related to non-vested stock option awards, which is expected to be recognized over a remaining weighted average vesting period of approximately 1.44 years. As of April 30, 2017, the aggregate intrinsic value of vested and exercisable options was approximately $48,000. In determining the fair value of the stock options granted during the six months ended April 30, 2017 and 2016, the Company used the following inputs in its BSM: Six Months Ended April 30, 2017 April 30, 2016 Expected Term 5.50-6.50 years 5.51-6.51 years Expected Volatility 107.07%-110.93 % 109.23%-115.25 % Expected Dividends 0 % 0 % Risk Free Interest Rate 1.26-1.58 % 1.65%-2.00 % Shares Issued to Consultants During the three months ended April 30, 2017, 44,312 shares of Common Stock valued at $379,350 were issued to consultants for services, of which $230,100 represented shares issued for amounts previously accrued. The Company recorded a liability on its balance sheet for $247,100 for shares earned pursuant to consulting agreements but not delivered. During the three months ended April 30, 2016, 65,893 shares of Common Stock valued at $570,001 were issued to consultants for services. The common stock share values were based on the dates the shares vested. During the six months ended April 30, 2017, 76,812 shares of Common Stock valued at $692,950 were issued to consultants for services, of which $75,000 represented shares issued for amounts previously accrued. The Company recorded a liability on its balance sheet for $247,100 for shares earned pursuant to consulting agreements but not delivered. During the six months ended April 30, 2016, 89,017 shares of Common Stock valued at $845,088 were issued to consultants for services. The common stock share values were based on the dates the shares vested. The following table summarizes share-based compensation expense included in the Statement of Operations by expense category for the six months ended April 30, 2017 and 2016, respectively: Three Months Ended April 30, Six Months Ended April 30, 2017 2016 2017 2016 Research and development $ 1,531,005 $ 967,705 $ 2,753,488 $ 6,074,343 General and administrative 3,682,720 3,864,872 7,570,662 8,287,240 Total $ 5,213,725 $ 4,832,577 $ 10,324,150 $ 14,361,583

Collaboration and Licensing Agr

Collaboration and Licensing Agreements	6 Months Ended
	Apr. 30, 2017
Business Combinations [Abstract]
Collaboration and Licensing Agreements	9. COLLABORATION AND LICENSING AGREEMENTS Especificos Stendhal SA de CV On February 3, 2016, the Company entered into a Co-Development and Commercialization Agreement (the “Stendhal Agreement”) with Especificos Stendhal SA de CV (“Stendhal”), for Advaxis’ lead Lm Technology™ immunotherapy, Axalimogene filolisbac , in HPV-associated cancers. Under the terms of the Stendhal Agreement, Stendhal will pay $10 million (“Support Payments”) towards the expense of AIM2CERV over the duration of the trial. Certain internal expenses of Stendhal up to $1 million shall be counted towards the $10 million in Support Payments. The Support Payments are contingent upon Advaxis achieving annual project milestones. The Company considered the provisions of the research and development and collaboration guidance in determining how to recognize the Support Payments to be received from Stendhal. The Company determined the Stendhal Agreement should be accounted for within the scope of collaboration arrangement accounting guidance. Furthermore, the Company determined that Advaxis is the principal in the Stendhal Agreement. As a result, the Company will account for the Support Payments as a reduction of research and development expenses Other Receivables Sellas Life Science Group On February 27, 2017, the Company entered into a license agreement with Sellas Life Science Group (“Sellas”) to develop a novel cancer immunotherapy agent using Advaxis’ proprietary Lm-based antigen delivery technology with SELLAS’ patented WT1 targeted heteroclitic peptide antigen mixture (galinpepimut-S)). Pursuant to the agreement, Advaxis will conduct all pre-clinical activities required for an IND filing and Sellas will be responsible for all clinical development and commercial activities. Advaxis will receive future payments of up to $358 million from SELLAS if certain development, regulatory, and commercial milestones are met. SELLAS has agreed to pay Advaxis single-digit to low double-digit royalties based on worldwide net sales upon commercialization. If SELLAS sublicenses its rights, Advaxis will receive a percentage of applicable sublicense revenue paid.

Commitments and Contingencies

Commitments and Contingencies	6 Months Ended
	Apr. 30, 2017
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	10. COMMITMENTS AND CONTINGENCIES Legal Proceedings Knoll On August 21, 2015, Knoll Capital Management L.P. filed a complaint against the Company in the Delaware Court of Chancery. In lieu of continuing to unnecessarily incur litigation expenses, on April 27, 2017, the Company settled the matter for a non-material amount, predominately reimbursed by the Company’s insurance, and the parties entered into a definitive confidential settlement agreement. The Company expressly denies any admission or wrongdoing and the settlement was entered into solely for the purpose of avoiding the burden, inconvenience, and expense of further litigation. On May 11, 2017, following resolution of the matter by the parties, the Court granted a Stipulation Of Dismissal With Prejudice. Bono On August 20, 2015, a derivative complaint was filed by a purported Company shareholder in the United States District Court for the District of New Jersey styled David Bono v. O’Connor, et al., Case No. 3:15-CV-006326-FLW-DEA (D.N.J. Aug. 20, 2015) (the “Bono Action”). The complaint is based on general allegations related to certain stock options granted to the individual defendants and generally alleges counts for breaches of fiduciary duty and unjust enrichment. The complaint also alleges additional claims for violation of Section 14(a) of the Securities Exchange Act of 1934 and for waste of corporate assets. The complaint seeks damages and costs of an unspecified amount, disgorgement of compensation obtained by the individual defendants, and injunctive relief. Defendants filed a motion to dismiss the Bono Action. On May 23, 2016, the United States District Court for the District of New Jersey issued an opinion and order granting in part and denying in part defendants’ motion to dismiss. Specifically, the court denied the motion to dismiss as to the breach of fiduciary duty claim and unjust enrichment claim against the three members of the Compensation Committee, but dismissed without prejudice the breach of fiduciary duty and unjust enrichment claims against the other eight individual defendants [O’Connor, Khleif, McKearn, Patton, Bonstein, Mauro, Mayes, and Petit]. The court dismissed without prejudice the Section 14(a) disclosure claim and waste claims against all defendants. On October 5, 2016, the court denied plaintiff’s motion for reconsideration of its May 23 order. On April 13, 2017, the parties advised the court that they have reached a tentative agreement in principle to settled the action, subject to court approval and formal documentation (including negotiating a stipulation of settlement and attorneys’ fees and expenses). At this stage of the proceeding, the Company does not express any opinion as to likely outcome, but the Company intends to defend the action vigorously. General The Company is from time to time involved in legal proceedings in the ordinary course of its business. The Company does not believe that any of these claims and proceedings against it is likely to have, individually or in the aggregate, a material adverse effect on its financial condition or results of operations. Operating Leases The Company’s corporate offices are currently located at 305 College Road East, Princeton, New Jersey 08540. Future minimum payments of the Company’s operating leases are as follows: Year ended October 31, 2017(Remaining) $ 490,931 2018 1,041,895 2019 1,107,385 2020 1,232,907 2021 1,317,640 Thereafter 5,747,340 10,938,098

Subsequent Events

Subsequent Events	6 Months Ended
	Apr. 30, 2017
Subsequent Events [Abstract]
Subsequent Events	11. SUBSEQUENT EVENTS On May 1, 2017, the Company granted to executives 258,758 RSUs and 145,749 PRSUs. The RSUs and PRSUs vest annually in three equal annual installments on November 1, 2017, November 1, 2018 and November 1, 2019. On May 30, 2017, the Company announced a clinical development collaboration with BMS to evaluate ADXS-DUAL, its second investigational immunotherapy targeting HPV-associated cancers, and BMS’ PD-1 immune checkpoint inhibitor, Opdivo ®

Summary of Significant Accoun17

Summary of Significant Accounting Policies and Basis of Presentation (Policies)	6 Months Ended
	Apr. 30, 2017
Accounting Policies [Abstract]
Basis of Presentation - Unaudited Interim Financial Information	Basis of Presentation - Unaudited Interim Financial Information The accompanying unaudited interim condensed financial statements and related notes have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) for interim financial information, and in accordance with the rules and regulations of the SEC with respect to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. The unaudited interim condensed financial statements furnished reflect all adjustments (consisting of normal recurring accruals) which are, in the opinion of management, necessary to represent a fair statement of the results for the interim periods presented. Interim results are not necessarily indicative of the results for the full year. These unaudited interim condensed financial statements should be read in conjunction with the financial statements of the Company for the year ended October 31, 2016 and notes thereto contained in the Company’s annual report on Form 10-K for the year ended October 31, 2016, as filed with the SEC on January 9, 2017. The information presented in the accompanying unaudited condensed balance sheet as of October 31, 2016 has been derived from the Company’s October 31, 2016 audited financial statements.
Estimates	Estimates The preparation of financial statements in accordance with U.S. GAAP involves the use of estimates and assumptions that affect the recorded amounts of assets and liabilities as of the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results may differ substantially from these estimates. Significant estimates include the fair value and recoverability of the carrying value of intangible assets (patents and licenses), the fair value of stock options, the fair value of embedded conversion features, warrants and related disclosure of contingent assets and liabilities. On an on-going basis, the Company evaluates its estimates, based on historical experience and on various other assumptions that it believes to be reasonable under the circumstances. Actual results may differ from estimates.
Reclassifications	Reclassifications Certain amounts in the prior period financial statements have been reclassified to conform to the presentation of the current period financial statements. These reclassifications had no effect on the previously reported net loss.
Collaboration Agreements	Collaboration Agreements The Company evaluates whether an arrangement is a collaborative arrangement under the Financial Accounting Standards Board (the “FASB”) Accounting Standards Certification (“ASC”) Topic 808, Collaborative Arrangements From time to time, the Company enters into collaborative arrangements for the research and development, manufacture and/or commercialization of products and product candidates. These collaborations generally provide for non-refundable, upfront license fees, research and development and commercial performance milestone payments, cost sharing, royalty payments and/or profit sharing. The Company’s collaboration agreements with third parties are performed on a ‘‘best efforts’’ basis with no guarantee of either technological or commercial success.
Revenue Recognition	Revenue Recognition The Company is expected to derive the majority of its revenue from patent licensing and research and development services associated with patent licensing. In general, these revenue arrangements provide for the payment of contractually determined fees in consideration for the grant of certain intellectual property rights for patented technologies owned or controlled by the Company. The intellectual property rights granted may be perpetual in nature, or upon the final milestones being met, or can be granted for a defined, relatively short period of time, with the licensee possessing the right to renew the agreement at the end of each contractual term for an additional minimum upfront payment. The Company recognizes licensing fees when there is persuasive evidence of a licensing arrangement, fees are fixed or determinable, delivery has occurred and collectability is reasonably assured. Revenue associated with nonrefundable upfront license fees under arrangements where the license fees and research and development activities cannot be accounted for as separate units of accounting is deferred and recognized as revenue on a straight-line basis over the expected period of performance. Revenues from the achievement of research and development milestones, if deemed substantive, are recognized as revenue when the milestones are achieved and the milestone payments are due and collectible. If not deemed substantive, the Company recognizes such milestones as revenue on a straight-line basis over the remaining expected performance period under the arrangement. All such recognized revenues are included in collaborative licensing and development revenue in the Company’s statements of operations. Milestones are considered substantive if all of the following conditions are met: (1) the milestone is nonrefundable; (2) achievement of the milestone was not reasonably assured at the inception of the arrangement; (3) substantive effort is involved to achieve the milestone; and (4) the amount of the milestone appears reasonable in relation to the effort expended, and the other milestones in the arrangement and the related risk associated with the achievement of the milestone and any ongoing research and development or other services are priced at fair value. If product development is successful, the Company will recognize revenue from royalties based on licensees’ sales of its products or products using its technologies. Royalties are recognized as earned in accordance with the contract terms when royalties from licensees can be reasonably estimated and collectability is reasonably assured. If royalties cannot be reasonably estimated or collectability of a royalty amount is not reasonably assured, royalties are recognized as revenue when the cash is received. Deferred revenue represents the portion of payments received for which the earnings process has not been completed. Deferred revenue expected to be recognized within the next 12 months is classified as a current liability. An allowance for doubtful accounts is established based on the Company’s best estimate of the amount of probable credit losses in the Company’s existing license fee receivables, using historical experience. The Company reviews its allowance for doubtful accounts periodically. Past due accounts are reviewed individually for collectability. Account balances are charged off against the allowance after all means of collection have been exhausted and the potential for recovery is considered remote. To date, this is yet to occur.
Cash and Cash Equivalents	Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be cash equivalents. As of April 30, 2017 and October 31, 2016, the Company had approximately $22.3 million and $106.7 million, respectively, in cash equivalents.
Concentration of Credit Risk	Concentration of Credit Risk The Company maintains its cash in bank deposit accounts (checking) that at times exceed federally insured limits. Approximately $28.7 million is subject to credit risk at April 30, 2017. However, these cash balances are maintained at creditworthy financial institutions. The Company has not experienced any losses in such accounts and believes it is not exposed to any significant credit risk.
Fair Value of Financial Instruments	Fair Value of Financial Instruments The carrying amounts of financial instruments, including cash, accounts payable and accrued expenses approximated fair value as of the balance sheet date presented, because of the relatively short maturity dates on these instruments. The carrying amounts of the financing arrangements issued approximate fair value as of the balance sheet date presented, because interest rates on these instruments approximate market interest rates after consideration of stated interest rates, anti-dilution protection and associated warrants.
Net Loss per Share	Net Loss per Share Basic net income or loss per common share is computed by dividing net income or loss available to common shareholders by the weighted average number of common shares outstanding during the period. Diluted earnings per share give effect to dilutive options, warrants, convertible debt and other potential Common Stock outstanding during the period. In the case of a net loss the impact of the potential Common Stock resulting from warrants, outstanding stock options and convertible debt are not included in the computation of diluted loss per share, as the effect would be anti-dilutive. In the case of net income, the impact of the potential Common Stock resulting from these instruments that have intrinsic value are included in the diluted earnings per share. The table sets forth the number of potential shares of Common Stock that have been excluded from diluted net loss per share. As of April 30, 2017 2016 Warrants 3,110,575 3,110,575 Stock Options 3,893,558 3,351,794 Restricted Stock Units 1,146,435 808,185 Total 8,150,568 7,270,554
Stock Based Compensation	Stock Based Compensation The Company has an equity plan which allows for the granting of stock options to its employees, directors and consultants for a fixed number of shares with an exercise price equal to the fair value of the shares at date of grant. The Company measures the cost of services received in exchange for an award of equity instruments based on the fair value of the award. For employees and directors, the fair value of the award is measured on the grant date and for non-employees, the fair value of the award is generally measured based on contractual terms. The fair value amount is then recognized over the requisite service period, usually the vesting period, in both research and development expenses and general and administrative expenses on the statement of operations, depending on the nature of the services provided by the employees or consultants. The process of estimating the fair value of stock-based compensation awards and recognizing stock-based compensation cost over their requisite service period involves significant assumptions and judgments. The Company estimates the fair value of stock option awards on the date of grant using the Black Scholes Model (“BSM”) for the remaining awards, which requires that the Company makes certain assumptions regarding: (i) the expected volatility in the market price of its Common Stock; (ii) dividend yield; (iii) risk-free interest rates; and (iv) the period of time employees are expected to hold the award prior to exercise (referred to as the expected holding period). As a result, if the Company revises its assumptions and estimates, stock-based compensation expense could change materially for future grants. The Company accounts for stock-based compensation using fair value recognition and records stock-based compensation as a charge to earnings net of forfeited awards. As such, the Company recognizes stock-based compensation cost only for those stock-based awards that vest over their requisite service period, based on the vesting provisions of the individual grants.
Recent Accounting Pronouncements	Recent Accounting Pronouncements In May 2014, as part of its ongoing efforts to assist in the convergence of GAAP and International Financial Reporting Standards, the FASB issued ASU 2014-09, Revenue from Contracts with Customers, which is a new standard related to revenue recognition. Under the new standard, recognition of revenue occurs when a customer obtains control of promised services or goods in an amount that reflects the consideration to which the entity expects to receive in exchange for those goods or services. In addition, the standard requires disclosure of the nature, amount, timing, and uncertainty of revenue and cash flows arising from customer contracts. The standard must be adopted using either a full retrospective approach for all periods presented in the period of adoption or a modified retrospective approach. In July 2015, the FASB issued ASU 2015-14, Revenue from Contracts with Customers - Deferral of the Effective Date, which defers the implementation of this new standard to be effective for fiscal years beginning after December 15, 2017. Early adoption is permitted effective January 1, 2017. In March 2016, the FASB issued ASU 2016-08, Principal versus Agent Considerations, which clarifies the implementation guidance on principal versus agent considerations in the new revenue recognition standard pursuant to ASU 2014-09. In April 2016, the FASB issued ASU 2016-10, Identifying Performance Obligations and Licensing, in May 2016, the FASB issued ASU 2016-12, Narrow-Scope Improvements and Practical Expedients, and in December 2016 the FASB issued ASU 2016-20, Technical Corrections and Improvements to Topic 606, Revenue from Contracts with Customers, which amend certain aspects of the new revenue recognition standard pursuant to ASU 2014-09. We are currently evaluating which transition approach we will utilize and the impact of adopting this accounting standard on the Company’s financial statements. In February 2016, the FASB issued ASU 2016-02, Leases (“ASU 2016-02”). The standard amends the existing accounting standards for lease accounting, including requiring lessees to recognize most leases on their balance sheets and making targeted changes to lessor accounting. ASU 2016-02 will be effective beginning in the first quarter of 2019. Early adoption of ASU 2016-02 is permitted. The new leases standard requires a modified retrospective transition approach for all leases existing at, or entered into after, the date of initial application, with an option to use certain transition relief. The Company is currently evaluating the impact of adopting ASU 2016-02 on the Company’s financial statements. In June 2016, the FASB issued ASU 2016-13, “Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments.” The standard significantly changes how entities will measure credit losses for most financial assets and certain other instruments that aren’t measured at fair value through net income. The standard will replace today’s “incurred loss” approach with an “expected loss” model for instruments measured at amortized cost. For available-for-sale debt securities, entities will be required to record allowances rather than reduce the carrying amount, as they do today under the other-than-temporary impairment model. It also simplifies the accounting model for purchased credit-impaired debt securities and loans. This ASU is effective for annual periods beginning after December 15, 2019, and interim periods therein. Early adoption is permitted for annual periods beginning after December 15, 2018, and interim periods therein. This ASU is not expected to have a material impact on the Company’s financial statements. In January 2017, the FASB issued ASU No. 2017-01, “Business Combinations (Topic 805): Clarifying the Definition of a Business.” The amendments in this Update clarify the definition of a business with the objective of adding guidance to assist entities with evaluating whether transactions should be accounted for as acquisitions (or disposals) of businesses. The amendments in this Update provide a screen to determine when a set is not a business. If the screen is not met, it (1) requires that to be considered a business, a set must include, at a minimum, an input and a substantive process that together significantly contribute to the ability to create output and (2) removes the evaluation of whether a market participant could replace the missing elements. This Update is the final version of Proposed ASU 2015-330 Business Combinations (Topic 805) – Clarifying The Definition of a Business, which has been deleted. The amendments in this Update are effective for all entities for annual periods, and interim periods within those annual periods, beginning after December 15, 2017. Early adoption is permitted. This ASU is not expected to have a material impact on the Company’s financial statements. In May 2017, the FASB issued ASU 2017-09, “Compensation—Stock Compensation (Topic 718): Scope of Modification Accounting” to provide clarity and reduce both (1) diversity in practice and (2) cost and complexity when applying the guidance in Topic 718, Compensation—Stock Compensation, to a change to the terms or conditions of a share-based payment award. The amendments in this Update provide guidance about which changes to the terms or conditions of a share-based payment award require an entity to apply modification accounting in Topic 718. This Update is the final version of Proposed ASU 2016-360—Compensation—Stock Compensation (Topic 718)—Scope of Modification Accounting, which has been deleted. The amendments in this Update are effective for all entities for annual periods, and interim periods within those annual periods, beginning after December 15, 2017. Early adoption is permitted. This ASU is not expected to have a material impact on the Company’s financial statements. Management does not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on the accompanying condensed financial statements.

Summary of Significant Accoun18

Summary of Significant Accounting Policies and Basis of Presentation (Tables)	6 Months Ended
	Apr. 30, 2017
Accounting Policies [Abstract]
Schedule of Common Stock Excluded from Diluted Net Loss Per Share	The table sets forth the number of potential shares of Common Stock that have been excluded from diluted net loss per share. As of April 30, 2017 2016 Warrants 3,110,575 3,110,575 Stock Options 3,893,558 3,351,794 Restricted Stock Units 1,146,435 808,185 Total 8,150,568 7,270,554

Investments (Tables)

Investments (Tables)	6 Months Ended
	Apr. 30, 2017
Schedule of Investments [Abstract]
Schedule of Investment Securities at Amortized	The following table summarizes the Company’s investment securities at amortized cost as of April 30, 2017 and October 31, 2016: April 30, 2017 Amortized cost, as adjusted Gross unrealized holding gains Gross unrealized holding losses Estimated fair value Short-term investments: Certificates of Deposit $ 22,531,815 $ - $ 1 $ 22,531,814 Domestic Governmental Agency Loans 2,666,074 - 1,963 2,664,111 U.S Treasury Notes 60,102,326 - 62,836 60,039,490 Total short-term investment securities $ 85,300,215 $ - $ 64,800 $ 85,235,415 October 31, 2016 Amortized cost, as adjusted Gross unrealized holding gains Gross unrealized holding losses Estimated fair value Short-term investments: Certificates of Deposit $ 10,737,563 $ - $ - $ 10,737,563 Domestic Governmental Agency Loans 2,500,000 - 250 2,499,750 U.S Treasury Notes 26,098,985 2,404 7,556 26,093,833 Total short-term investment securities $ 39,336,548 $ 2,404 $ 7,806 $ 39,331,146

Property and Equipment (Tables)

Property and Equipment (Tables)	6 Months Ended
	Apr. 30, 2017
Property, Plant and Equipment [Abstract]
Schedule of Property and Equipment	Property and equipment consists of the following: April 30, 2017 October 31, 2016 Leasehold Improvements $ 2,010,952 $ 1,835,602 Laboratory Equipment 3,423,753 2,038,704 Furniture and Fixtures 693,173 549,025 Computer Equipment 321,777 240,910 Construction in Progress 869,840 151,368 Total Property and Equipment 7,319,495 4,815,609 Accumulated Depreciation and Amortization (753,434 ) (426,535 ) Net Property and Equipment $ 6,566,061 $ 4,389,074

Intangible Assets (Tables)

Intangible Assets (Tables)	6 Months Ended
	Apr. 30, 2017
Goodwill and Intangible Assets Disclosure [Abstract]
Summary of Intangible Assets	The following is a summary of intangible assets as of the end of the following fiscal periods: April 30, 2017 October 31, 2016 License $ 776,992 $ 776,992 Patents 5,487,414 4,980,610 Software 25,625 19,625 Total Intangibles 6,290,031 5,777,227 Accumulated Amortization (1,595,762 ) (1,448,106 ) Intangible Assets $ 4,694,269 $ 4,329,121
Schedule of Amortization Expense	Estimated amortization expense for the next five years is as follows: Year ended October 31, 2017 (Remaining) $ 155,000 2018 311,000 2019 308,000 2020 302,000 2021 302,000

Accrued Expenses (Tables)

Accrued Expenses (Tables)	6 Months Ended
	Apr. 30, 2017
Payables and Accruals [Abstract]
Schedule of Accrued Expenses	The following table represents the major components of accrued expenses: April 30, 2017 October 31, 2016 Salaries and Other Compensation $ 1,679,995 $ 2,467,650 Vendors 632,259 2,098,792 Professional Fees 3,779,973 6,338,561 Accrued Expenses $ 6,092,227 $ 10,905,003

Derivative Instruments (Tables)

Derivative Instruments (Tables)	6 Months Ended
	Apr. 30, 2017
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Schedule of Warrants Activity	A summary of changes in warrants for the six months ended April 30, 2017 is as follows: Number of Weighted-Average Warrants Exercise Price Outstanding Warrants at October 31, 2016: 3,110,575 $ 5.04 Issued - - Exercised - - Expired - - Outstanding Warrants at April 30, 2017 3,110,575 $ 5.04
Schedule of Fair Value of Warrant Liability	In determining the fair value of the warrant liability at April 30, 2017 and October 31, 2016, the Company used the following inputs in its BSM: April 30, 2017 October 31, 2016 Exercise Price $ 10.63-18.75 $ 10.63-18.75 Stock Price $ 8.56 $ 8.09 Expected term 0.05-0.26 years 0.55-0.75 years Expected Volatility 34.44%-43.74 % 81.84%-87.09 % Risk Free Interest Rate 0.68%-0.80 % 0.51%-0.66 %

Share Based Compensation (Table

Share Based Compensation (Tables)	6 Months Ended
	Apr. 30, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Schedule of Allocation of Base Salary	The table below reflects the purchases of each Executive: ANNUALIZED Annual Amount For the Six Months Ended April 30, 2017 to be Purchased Gross Purchase Net Purchase Executive $ $ # of shares $ # of shares Daniel J. O’Connor $ 54,547 $ 26,546 2,080 $ 20,008 1,558 Robert G. Petit $ 33,061 $ 16,065 1,811 $ 12,786 1,295 Sara M. Bonstein $ 29,261 $ 14,260 1,158 $ 9,978 845
Summary of RSU Activity and Related Information	A summary of the Company’s RSU activity and related information for the six months ended April 30, 2017 is as follows: Number of Weighted-Average Balance at October 31, 2016: 719,448 $ 10.77 Granted 722,432 $ 8.38 Vested (270,134 ) $ 9.28 Cancelled (25,311 ) $ 9.09 Balance at April 30, 2017 1,146,435 $ 9.65
Summary of Changes in Stock Option Plan	A summary of changes in the stock option plan for the six months ended April 30, 2017 is as follows: Number of Weighted-Average Options Exercise Price Outstanding at October 31, 2016: 3,351,795 $ 13.31 Granted 556,952 $ 7.71 Exercised - $ - Canceled (4,000 ) $ 3.42 Expired (11,189 ) $ 17.88 Outstanding at April 30, 2017 3,893,558 $ 12.51 Vested and Exercisable at April 30, 2017 2,158,092 $ 13.47
Summary of Fair Value of Stock Options Granted of BSM	In determining the fair value of the stock options granted during the six months ended April 30, 2017 and 2016, the Company used the following inputs in its BSM: Six Months Ended April 30, 2017 April 30, 2016 Expected Term 5.50-6.50 years 5.51-6.51 years Expected Volatility 107.07%-110.93 % 109.23%-115.25 % Expected Dividends 0 % 0 % Risk Free Interest Rate 1.26-1.58 % 1.65%-2.00 %
Summary of Share-based Compensation Expense	The following table summarizes share-based compensation expense included in the Statement of Operations by expense category for the six months ended April 30, 2017 and 2016, respectively: Three Months Ended April 30, Six Months Ended April 30, 2017 2016 2017 2016 Research and development $ 1,531,005 $ 967,705 $ 2,753,488 $ 6,074,343 General and administrative 3,682,720 3,864,872 7,570,662 8,287,240 Total $ 5,213,725 $ 4,832,577 $ 10,324,150 $ 14,361,583

Commitments and Contingencies (

Commitments and Contingencies (Tables)	6 Months Ended
	Apr. 30, 2017
Commitments and Contingencies Disclosure [Abstract]
Summary of Future Minimum Payments of Operating Leases	Future minimum payments of the Company’s operating leases are as follows: Year ended October 31, 2017(Remaining) $ 490,931 2018 1,041,895 2019 1,107,385 2020 1,232,907 2021 1,317,640 Thereafter 5,747,340 10,938,098

Nature of Operations (Details N

Nature of Operations (Details Narrative)	6 Months Ended
	Apr. 30, 2017USD ($)Patients
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of patients | Patients	110
Cash, cash equivalents and investments | $	$ 115,300,000

Summary of Significant Accoun27

Summary of Significant Accounting Policies and Basis of Presentation (Details Narrative) - USD ($)	6 Months Ended
	Apr. 30, 2017	Oct. 31, 2016
Accounting Policies [Abstract]
Cash equivalents	$ 22,300,000	$ 106,700,000
Concentration of credit risk	$ 28,700,000

Summary of Significant Accoun28

Summary of Significant Accounting Policies and Basis of Presentation - Schedule of Common Stock Excluded from Diluted Net Loss Per Share (Details) - shares	6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016
Number of common stock excluded from diluted net loss per share	8,150,568	7,270,554
Warrants [Member]
Number of common stock excluded from diluted net loss per share	3,110,575	3,110,575
Stock Options [Member]
Number of common stock excluded from diluted net loss per share	3,893,558	3,351,794
Restricted Stock Units (RSUs) [Member]
Number of common stock excluded from diluted net loss per share	1,146,435	808,185

Investments (Details Narrative)

Investments (Details Narrative)	6 Months Ended
	Apr. 30, 2017
Schedule of Investments [Abstract]
Investments maturity description	All of the Company's investments mature within the next 12 months.

Investments - Schedule of Inves

Investments - Schedule of Investment Securities at Amortized (Details) - USD ($)	6 Months Ended	12 Months Ended
	Apr. 30, 2017	Oct. 31, 2016
Amortized cost, as adjusted	$ 85,300,215	$ 39,336,548
Gross unrealized holding gains		2,404
Gross unrealized holding losses	64,800	7,806
Estimated fair value	85,235,415	39,331,146
Certificates of Deposit [Member]
Amortized cost, as adjusted	22,531,815	10,737,563
Gross unrealized holding gains
Gross unrealized holding losses	1
Estimated fair value	22,531,814	10,737,563
Domestic Governmental Agency Loans [Member]
Amortized cost, as adjusted	2,666,074	2,500,000
Gross unrealized holding gains
Gross unrealized holding losses	1,963	250
Estimated fair value	2,664,111	2,499,750
U.S Treasury Notes [Member]
Amortized cost, as adjusted	60,102,326	26,098,985
Gross unrealized holding gains		2,404
Gross unrealized holding losses	62,836	7,556
Estimated fair value	$ 60,039,490	$ 26,093,833

Property and Equipment (Details

Property and Equipment (Details Narrative) - USD ($)	3 Months Ended		6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 179,823	$ 49,090	$ 337,403	$ 95,124

Property and Equipment - Schedu

Property and Equipment - Schedule of Property and Equipment (Details) - USD ($)	Apr. 30, 2017	Oct. 31, 2016
Property, Plant and Equipment [Abstract]
Leasehold Improvements	$ 2,010,952	$ 1,835,602
Laboratory Equipment	3,423,753	2,038,704
Furniture and Fixtures	693,173	549,025
Computer Equipment	321,777	240,910
Construction in Progress	869,840	151,368
Total Property and Equipment	7,319,495	4,815,609
Accumulated Depreciation and Amortization	(753,434)	(426,535)
Net Property and Equipment	$ 6,566,061	$ 4,389,074

Intangible Assets (Details Narr

Intangible Assets (Details Narrative) - USD ($)	3 Months Ended		6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016
Goodwill and Intangible Assets Disclosure [Abstract]
Finite lived patents expirations year			The expirations of the existing patents range from 2017 to 2037
Book value patent applications, net	$ 89,881		$ 89,881
Amortization of intangible assets	$ 77,745	$ 60,798	$ 152,155	$ 118,744

Intangible Assets - Summary of

Intangible Assets - Summary of Intangible Assets (Details) - USD ($)	Apr. 30, 2017	Oct. 31, 2016
Goodwill and Intangible Assets Disclosure [Abstract]
License	$ 776,992	$ 776,992
Patents	5,487,414	4,980,610
Software	25,625	19,625
Total intangibles	6,290,031	5,777,227
Accumulated Amortization	(1,595,762)	(1,448,106)
Intangible Assets	$ 4,694,269	$ 4,329,121

Intangible Assets - Schedule of

Intangible Assets - Schedule of Amortization Expense (Details)	Oct. 31, 2016USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]
2017 (Remaining)	$ 155,000
2,018	311,000
2,019	308,000
2,020	302,000
2,021	$ 302,000

Accrued Expenses - Schedule of

Accrued Expenses - Schedule of Accrued Expenses (Details) - USD ($)	Apr. 30, 2017	Oct. 31, 2016
Payables and Accruals [Abstract]
Salaries and Other Compensation	$ 1,679,995	$ 2,467,650
Vendors	632,259	2,098,792
Professional Fees	3,779,973	6,338,561
Accrued Expenses	$ 6,092,227	$ 10,905,003

Derivative Instruments (Details

Derivative Instruments (Details Narrative) - USD ($)	3 Months Ended		6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016	Oct. 31, 2016
Warrants outstanding	3,110,575		3,110,575		3,110,575
Fair value of warrant liability					$ 20,156
Gain (loss) on change in fair value of warrant liability	$ 10,652	$ 592	$ 20,156	$ 49,874
Equity Warrants [Member]
Common stock purchase warrant	3,090,000		3,090,000		3,090,000
Warrants outstanding	3,110,000		3,110,000		3,110,000
Liability Warrants [Member]
Common stock purchase warrant	18,000		18,000		18,000
Warrants outstanding	3,110,000		3,110,000		3,110,000

Derivative Instruments - Schedu

Derivative Instruments - Schedule of Warrants Activity (Details)	6 Months Ended
	Apr. 30, 2017$ / sharesshares
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Number of Warrants, Outstanding, Beginning balance | shares	3,110,575
Number of Warrants, Issued | shares
Number of Warrants, Exercised | shares
Number of Warrants, Expired | shares
Number of Warrants, Outstanding, Ending balance | shares	3,110,575
Weighted-Average Exercise Price, Outstanding, Beginning | $ / shares	$ 5.04
Weighted-Average Exercise Price, Issued | $ / shares
Weighted-Average Exercise Price, Exercised | $ / shares
Weighted-Average Exercise Price, Expired | $ / shares
Weighted-Average Exercise Price, Outstanding, Ending | $ / shares	$ 5.04

Derivative Instruments - Sche39

Derivative Instruments - Schedule of Fair Value of Warrant Liability (Details) - $ / shares	6 Months Ended	12 Months Ended
	Apr. 30, 2017	Oct. 31, 2016
Stock Price	$ 8.56	$ 8.09
Minimum [Member]
Exercise Price	$ 10.63	$ 10.63
Expected term	18 days	6 months 18 days
Expected Volatility	34.44%	81.84%
Risk Free Interest Rate	0.68%	0.51%
Maximum [Member]
Exercise Price	$ 18.75	$ 18.75
Expected term	3 months 4 days	9 months
Expected Volatility	43.74%	87.09%
Risk Free Interest Rate	0.80%	0.66%

Share Based Compensation (Detai

Share Based Compensation (Details Narrative) - USD ($)	1 Months Ended		3 Months Ended		6 Months Ended
	Mar. 31, 2014	Oct. 31, 2013	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016	Jan. 31, 2016
Stock compensation expense			$ 37,308	$ 56,926	$ 79,324	$ 121,257
Share-based compensation, common stock, shares			4,395	8,028	9,711	15,088
Share-based compensation, shares on net basis after employee payroll taxes			3,224	5,785	7,295	10,732
Unrecognized compensation cost related to non-vested stock option awards			$ 14,678,000		$ 14,678,000
Unrecognized compensation cost related to non-vested remaining weighted average vesting period					1 year 5 months 9 days
Options outstanding, intrinsic value			48,000		$ 48,000
Fair value of equity purchases							$ 102,022
Fair value of equity purchases, shares							9,150
Compensation cost related to outstanding stock options			3,006,763	$ 3,280,517	$ 6,190,221	$ 9,952,502
Number of options, granted					556,952	1,385,000
Fair value of option granted					$ 3,542,215	$ 14,837,970
Restricted Stock Units (RSUs) [Member]
Unrecognized compensation cost related to non-vested stock option awards			9,247,000		$ 9,247,000
Unrecognized compensation cost related to non-vested remaining weighted average vesting period					2 years 2 months 8 days
Options outstanding, intrinsic value			9,814,000		$ 9,814,000
Number of options, granted					722,432
Employee Stock Awards [Member]
Stock compensation expense			$ 1,674,989	$ 876,228	$ 2,989,612	$ 2,733,304
Share-based compensation, common stock, shares			155,149	134,239	243,809	372,368
Share-based compensation, shares on net basis after employee payroll taxes			126,504		215,164
2013 Base Salary Stock [Member]
Issuance of common stock shares					34,752
Number of stock shares issued during period amount					$ 186,555
Issuance of common stock net basis after taxes					21,489
2014 Cash Bonus Equity [Member]
Issuance of common stock shares					62,064
Number of stock shares issued during period amount					$ 214,359
Issuance of common stock net basis after taxes					57,990
2014 Voluntary Request To Purchase Of Equity [Member]
Issuance of common stock shares					21,687
Number of stock shares issued during period amount					$ 68,750
Issuance of common stock net basis after taxes					15,950
2015 Voluntary Request To Purchase Of Equity [Member]
Issuance of common stock shares					8,482
Number of stock shares issued during period amount					$ 88,840
Issuance of common stock net basis after taxes					7,556
Common Stock [Member]
Issuance of common stock shares	3,333	13,500
Number of stock shares issued during period amount	$ 10,000	$ 54,000
Promissory Note One [Member]
Issuance of common stock shares					21,091
Number of stock shares issued during period amount					$ 66,500
Daniel J. O' Connor [Member]
Issuance of common stock shares					164,909
Number of stock shares issued during period amount					$ 689,004
Directors [Member]
Stock compensation expense			$ 30,000	$ 61,767	$ 30,000	$ 93,534
Share-based compensation, common stock, shares			98,315	311,205	199,943	622,410
Consultants [Member]
Unrecognized compensation cost related to non-vested stock option awards			$ 230,100		$ 230,100
Stock issued during period for services			44,312	65,893
Stock issued during period value for services			$ 379,350	$ 570,001
Recorded a liability			247,100		247,100
Consultants [Member]
Unrecognized compensation cost related to non-vested stock option awards			75,000		$ 75,000
Stock issued during period for services					76,812	89,017
Stock issued during period value for services					$ 692,950	$ 845,088
Recorded a liability			$ 247,100		$ 247,100

Share Based Compensation - Sche

Share Based Compensation - Schedule of Allocation of Base Salary (Details) - USD ($)	3 Months Ended		6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016
Annual Amount to be Purchased	$ 5,213,725	$ 4,832,577	$ 10,324,150	$ 14,361,583
Daniel J. O' Connor [Member]
Annual Amount to be Purchased			54,547
Cumulative Gross Purchase			$ 26,546
Cumulative shares Gross Purchase			2,080
Cumulative Net Purchase			$ 20,008
Cumulative shares Net Purchase			1,558
Robert G. Petit [Member]
Annual Amount to be Purchased			$ 33,061
Cumulative Gross Purchase			$ 16,065
Cumulative shares Gross Purchase			1,811
Cumulative Net Purchase			$ 12,786
Cumulative shares Net Purchase			1,295
Sara M. Bonstein [Member]
Annual Amount to be Purchased			$ 29,261
Cumulative Gross Purchase			$ 14,260
Cumulative shares Gross Purchase			1,158
Cumulative Net Purchase			$ 9,978
Cumulative shares Net Purchase			845

Share Based Compensation - Summ

Share Based Compensation - Summary of RSU Activity and Related Information (Details) - $ / shares	6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016
Beginning Balance	3,351,795
Number of RSUs, Granted	556,952	1,385,000
Number of RSUs, Vested
Ending Balance	3,893,558
Weighted-Average Exercise Price, Outstanding, Beginning	$ 13.31
Weighted-Average Exercise Price, Granted	7.71
Weighted-Average Exercise Price, Vested
Weighted-Average Exercise Price, Outstanding, Ending	$ 12.51
Restricted Stock Units (RSUs) [Member]
Beginning Balance	719,448
Number of RSUs, Granted	722,432
Number of RSUs, Vested	(270,134)
Number of RSUs, Cancelled	(25,311)
Ending Balance	1,146,435
Weighted-Average Exercise Price, Outstanding, Beginning	$ 10.77
Weighted-Average Exercise Price, Granted	8.38
Weighted-Average Exercise Price, Vested	9.28
Weighted-Average Exercise Price, Cancelled	9.09
Weighted-Average Exercise Price, Outstanding, Ending	$ 9.65

Share Based Compensation - Su43

Share Based Compensation - Summary of Changes in Stock Option Plan (Details) - $ / shares	6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Beginning Balance	3,351,795
Number of Options, Granted	556,952	1,385,000
Number of Options, Exercised
Number of Options, Canceled	(4,000)
Number of Options, Expired	(11,189)
Ending Balance	3,893,558
Number of Options, Vested and Exercisable	2,158,092
Weighted-Average Exercise Price, Outstanding, Beginning	$ 13.31
Weighted-Average Exercise Price, Granted	7.71
Weighted-Average Exercise Price, Exercised
Weighted-Average Exercise Price, Canceled	3.42
Weighted-Average Exercise Price, Expired	17.88
Weighted-Average Exercise Price, Outstanding, Ending	12.51
Weighted-Average Exercise Price, Vested and Exercisable	$ 13.47

Share Based Compensation - Su44

Share Based Compensation - Summary of Fair Value of Stock Options Granted of BSM (Details)	6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016
Expected Volatility, Minimum	107.07%	109.23%
Expected Volatility, Maximum	110.93%	115.25%
Expected Dividends	0.00%	0.00%
Risk Free Interest Rate, Minimum	1.26%	1.65%
Risk Free Interest Rate, Maximum	1.58%	2.00%
Minimum [Member]
Expected Term	5 years 6 months	5 years 6 months 3 days
Maximum [Member]
Expected Term	6 years 6 months	6 years 6 months 3 days

Share Based Compensation - Su45

Share Based Compensation - Summary of Share-based Compensation Expense (Details) - USD ($)	3 Months Ended		6 Months Ended
	Apr. 30, 2017	Apr. 30, 2016	Apr. 30, 2017	Apr. 30, 2016
Share-based compensation expense	$ 5,213,725	$ 4,832,577	$ 10,324,150	$ 14,361,583
Research and Development [Member]
Share-based compensation expense	1,531,005	967,705	2,753,488	6,074,343
General and Administrative [Member]
Share-based compensation expense	$ 3,682,720	$ 3,864,872	$ 7,570,662	$ 8,287,240

Collaboration And Licensing A46

Collaboration And Licensing Agreements (Details Narrative) - USD ($)	Feb. 03, 2016	Apr. 30, 2017	Feb. 27, 2017	Oct. 31, 2016
Other Receivable		$ 3,000,000
Sellas Life Science Group [Member]
Received payments from related parties			$ 358,000,000
May 2017 [Member]
Received payments from related parties		$ 3,000,000
Stendhal Agreement [Member]
Support payment expenses	$ 10,000,000
Support payment expense description	Certain internal expenses of Stendhal up to $1 million shall be counted towards the $10 million in Support Payments.
Maximum internal expense	$ 1,000,000

Commitments and Contingencies -

Commitments and Contingencies - Summary of Future Minimum Payments of Operating Leases (Details)	Oct. 31, 2016USD ($)
Commitments and Contingencies Disclosure [Abstract]
2017 (Remaining)	$ 490,931
2,018	1,041,895
2,019	1,107,385
2,020	1,232,907
2,021	1,317,640
Thereafter	5,747,340
Total	$ 10,938,098

Subsequent Events (Details Narr

Subsequent Events (Details Narrative) - Subsequent Event [Member]	May 02, 2017USD ($)
Stock granted during period	$ 145,749
Stock vesting period description	The RSUs and PRSUs vest annually in three equal annual installments on November 1, 2017, November 1, 2018 and November 1, 2019.
Restricted Stock Units (RSUs) [Member]
Stock granted during period	$ 258,758