Alaunos Therapeutics (TCRT) 10-Q 7 Aug 14 2014 Q2 Quarterly report Financial data

Document_and_Entity_Informatio

Document and Entity Information	6 Months Ended
	Jun. 30, 2014	Jul. 31, 2014
Document Information [Line Items]	'	'
Document Type	'10-Q	'
Amendment Flag	'false	'
Document Period End Date	30-Jun-14	'
Document Fiscal Year Focus	'2014	'
Document Fiscal Period Focus	'Q2	'
Trading Symbol	'ZIOP	'
Entity Registrant Name	'ZIOPHARM ONCOLOGY INC	'
Entity Central Index Key	'0001107421	'
Current Fiscal Year End Date	'--12-31	'
Entity Filer Category	'Accelerated Filer	'
Entity Common Stock, Shares Outstanding	'	100,742,889

Balance_Sheets

Balance Sheets (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Current assets:	'	'
Cash and cash equivalents	$53,001	$68,204
Receivables	32	145
Prepaid expenses and other current assets	991	1,948
Total current assets	54,024	70,297
Property and equipment, net	683	801
Deposits	128	128
Other non-current assets	513	528
Total assets	55,348	71,754
Current liabilities:	'	'
Accounts payable	447	422
Accrued expenses	7,773	6,357
Deferred revenue - current portion	2,333	800
Deferred rent - current portion	235	212
Total current liabilities	10,788	7,791
Deferred revenue	'	1,933
Deferred rent	730	851
Warrant liabilities	6,094	11,776
Other long-term liabilities	20	20
Total liabilities	17,632	22,371
Commitments and contingencies (note 8)	'	'
Stockholders' equity:	'	'
Preferred stock, $0.001 par value; 30,000,000 shares authorized and no shares issued and outstanding	'	'
Common stock, $0.001 par value; 250,000,000 shares authorized; 100,725,066 and 100,159,618 shares issued and outstanding at June 30, 2014 and December 31, 2013, respectively	101	100
Additional paid-in capital - common stock	390,192	386,511
Additional paid-in capital - warrants issued	3,541	3,603
Accumulated deficit	-356,118	-340,831
Total stockholders' equity	37,716	49,383
Total liabilities and stockholders' equity	$55,348	$71,754

Balance_Sheets_Parenthetical

Balance Sheets (Parenthetical) (USD $)	Jun. 30, 2014	Dec. 31, 2013
Preferred stock, par value	$0.00	$0.00
Preferred stock, shares authorized	30,000,000	30,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$0.00	$0.00
Common stock, shares authorized	250,000,000	250,000,000
Common stock, shares issued	100,725,066	100,159,618
Common stock, shares outstanding	100,725,066	100,159,618

Statements_of_Operations

Statements of Operations (USD $)	3 Months Ended		6 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Research contract revenue	$200	$200	$400	$400
Operating expenses:	'	'	'	'
Research and development, including costs of research contracts	8,346	14,775	14,888	33,887
General and administrative	3,031	3,721	6,473	8,392
Total operating expenses	11,377	18,496	21,361	42,279
Loss from operations	-11,177	-18,296	-20,961	-41,879
Other income (expense), net	1	7	-8	3
Change in fair value of warrants	5,600	-403	5,682	10,385
Net loss	($5,576)	($18,692)	($15,287)	($31,491)
Net loss per share - basic and diluted	($0.06)	($0.22)	($0.15)	($0.38)
Weighted average common shares outstanding to compute net loss per share - basic and diluted	100,422,564	83,082,633	100,326,416	82,994,845

Statement_of_Stockholders_Equi

Statement of Stockholders' Equity (USD $)	Total	Preferred Stock	Common Stock	Additional Paid-in Capital Common Stock	Additional Paid-in Capital Warrants	Deficit Accumulated During the Development Stage
In Thousands, except Share data
Beginning Balance at Dec. 31, 2013	$49,383	$0	$100	$386,511	$3,603	($340,831)
Beginning Balance (in shares) at Dec. 31, 2013	'	0	100,159,618	'	'	'
Warrant exercise (in shares)	'	'	21,977	'	'	'
Warrant exercise	'	'	'	62	-62	'
Stock-based compensation	2,435	'	'	2,435	'	'
Exercise of employee stock options (in shares)	583,038	'	583,038	'	'	'
Exercise of employee stock options	1,317	'	1	1,316	'	'
Cancelled restricted stock (in shares)	'	'	-8,936	'	'	'
Cancelled restricted stock	'	'	'	'	'	'
Repurchase of shares of restricted common stock (in shares)	'	'	-30,631	'	'	'
Repurchase of shares of restricted common stock	-132	'	'	-132	'	'
Net loss	-15,287	'	'	'	'	-15,287
Ending Balance at Jun. 30, 2014	$37,716	$0	$101	$390,192	$3,541	($356,118)
Ending Balance (in shares) at Jun. 30, 2014	'	0	100,725,066	'	'	'

Statements_of_Cash_Flows

Statements of Cash Flows (USD $)	6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013
Cash flows from operating activities:	'	'
Net loss	($15,287)	($31,491)
Adjustments to reconcile net loss to net cash used in operating activities:	'	'
Depreciation and amortization	217	396
Stock-based compensation	2,435	1,673
Change in fair value of warrants	-5,682	-10,385
(Increase) decrease in:	'	'
Receivables	113	27
Prepaid expenses and other current assets	957	2,845
Other noncurrent assets	15	269
Deposits	'	4
Increase (decrease) in:	'	'
Accounts payable	25	-344
Accrued expenses	1,416	2,453
Deferred revenue	-400	-400
Deferred rent	-98	-11
Net cash used in operating activities	-16,289	-34,964
Cash flows from investing activities:	'	'
Purchases of property and equipment	-99	-115
Net cash used in investing activities	-99	-115
Cash flows from financing activities:	'	'
Proceeds from exercise of stock options	1,317	854
Payments to employees for repurchase of common stock	-132	-250
Proceeds from exercise of warrants	'	101
Net cash provided by financing activities	1,185	705
Net increase (decrease) in cash and cash equivalents	-15,203	-34,374
Cash and cash equivalents, beginning of period	68,204	73,306
Cash and cash equivalents, end of period	53,001	38,932
Supplementary disclosure of cash flow information:	'	'
Cash paid for interest	0	0
Cash paid for income taxes	0	0
Supplementary disclosure of noncash investing and financing activities:	'	'
Exercise of equity-classified warrants to common shares	$62	$72

Business

Business	6 Months Ended
	Jun. 30, 2014
Business	'
	1. Business
	Overview
	ZIOPHARM Oncology, Inc., which we refer to as “ZIOPHARM” or the “Company”, is a biopharmaceutical company that seeks to acquire, develop and commercialize, on its own or with commercial partners, a diverse portfolio of cancer therapies that can address unmet medical needs.
	The Company’s operations to date have consisted primarily of raising capital and conducting research and development. The Company’s fiscal year ends on December 31.
	The Company has operated at a loss since its inception in 2003 and has minimal revenues. The Company anticipates that losses will continue for the foreseeable future. At June 30, 2014, the Company’s accumulated deficit was approximately $356.1 million. Based upon our current plans, we anticipate that our cash resources will be sufficient to fund our operations into the third quarter of 2015. The Company’s ability to continue operations after its current cash resources are exhausted depends on its ability to obtain additional financing or to achieve profitable operations, as to which no assurances can be given. Cash requirements may vary materially from those now planned because of changes in the Company’s focus and direction of its research and development programs, competitive and technical advances, patent developments, regulatory changes or other developments. Additional financing will be required to continue operations after the Company exhausts its current cash resources and to continue its long-term plans for clinical trials and new product development. There can be no assurance that any such financing can be obtained by the Company, or if obtained, what the terms thereof may be, or that any amount that the Company is able to raise will be adequate to support the Company’s working capital requirements until it achieves profitable operations.
	Basis of Presentation
	The accompanying unaudited interim financial statements have been prepared in accordance with the instructions to Form 10-Q pursuant to the rules and regulations of the Securities and Exchange Commission. Certain information and note disclosures required by generally accepted accounting principles in the United States have been condensed or omitted pursuant to such rules and regulations.
	It is management’s opinion that the accompanying unaudited interim financial statements reflect all adjustments (which are normal and recurring) that are necessary for a fair statement of the results for the interim periods. The unaudited interim financial statements should be read in conjunction with the audited financial statements and the notes thereto for the year ended December 31, 2013, included in the Company’s Form 10-K, for such fiscal year.
	The year-end balance sheet data was derived from the audited financial statements but does not include all disclosures required by generally accepted accounting principles in the United States.
	The results disclosed in the Statements of Operations for the three and six months ended June 30, 2014 are not necessarily indicative of the results to be expected for the full fiscal year.
	Use of Estimates
	The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Although the Company regularly assesses these estimates, actual results could differ from those estimates. Changes in estimates are recorded in the period in which they become known.
	The Company’s most significant estimates and judgments used in the preparation of its financial statements are:
		•	Clinical trial expenses;
		•	Fair value measurements for stock based compensation and warrants; and
		•	Income taxes.
	Subsequent Events
	The Company evaluated all events and transactions that occurred after the balance sheet date through the date of this filing. Except as disclosed in Note 8, the Company did not have any other material subsequent events that impacted its financial statements or disclosures.

Summary_of_Significant_Account

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2014
Summary of Significant Accounting Policies	'
	2. Summary of Significant Accounting Policies
	The Company’s significant accounting policies were identified in the Company’s Form 10-K for the fiscal year ended December 31, 2013. There have been no material changes in those policies since the filing of our Form 10-K.

Recently_Issued_Accounting_Pro

Recently Issued Accounting Pronouncements	6 Months Ended
	Jun. 30, 2014
Recently Issued Accounting Pronouncements	'
	3. Recently Issued Accounting Pronouncements
	On June 10, 2014, the FASB issued ASU 2014-10, Development Stage Entities (Topic 915), which simplifies financial reporting for development stage entities by eliminating requirements specific to development stage entities. As a result, entities in a development stage will no longer need to present inception-to-date information about income statement line items, cash flows, and equity transactions. Instead, the new guidance clarifies how these entities should tailor existing disclosures to explain the risks and uncertainties related to their activities. This update is effective for annual periods beginning after December 15, 2014, and early application is permitted for any annual or interim period for which the entity’s financial statements have not yet been issued. The Company adopted this guidance prior to issuing the financial statements in this Quarterly Report on Form 10-Q. The adoption of ASU 2014-10 impacted presentation and disclosure only and did not have any impact on financial position or results of operations.

Restructuring

Restructuring	6 Months Ended
	Jun. 30, 2014
Restructuring	'
	4. Restructuring
	On April 3, 2013, the Company completed a workforce reduction plan to reduce costs as part of the Company’s decision to terminate development of palifosfamide in first-line metastatic soft tissue sarcoma and place exclusive strategic focus on its synthetic biology programs, which are being developed in partnership with Intrexon Corporation (“Intrexon”) (see Notes 7 and 8). Pursuant to the workforce reduction plan, the Company eliminated a total of 65 positions, comprised of 40 filled positions and 25 unfilled positions across various functions and locations. Employees whose positions were eliminated as part of the plan were notified beginning on April 2, 2013. Affected employees were offered separation benefits, including severance payments, and temporary healthcare coverage assistance. In connection with the elimination of filled positions as part of the workforce reduction plan, the Company incurred charges of $1.7 million during the second quarter of 2013, primarily for one-time contractual severance benefits.
	On August 30, 2013, the Company entered into a sublease agreement to lease 5,249 square feet in the Company’s Boston office to a subtenant. The company remains primarily liable to pay rent on the original lease. The Company recorded a loss on the sublease in the amount of $42 thousand during the year ended December 31, 2013, representing the remaining contractual obligation of $367 thousand, less $325 thousand in future payments from the subtenant. The Company retired assets in this subleased area as a result of this sublease with a net book value of $194 thousand, and recorded a loss on disposal of fixed assets for the same amount in the year ended December 31, 2013.
	On October 17, 2013, the Company entered into a sublease agreement to lease 7,259 square feet in the Company’s New York office to a subtenant. The Company remains primarily liable to pay rent on the original lease. The Company recorded a loss on the sublease in the amount of $729 thousand for the year ended December 31, 2013, representing the remaining contractual obligation of $2.3 million, less $1.6 million in future payments from the subtenant. The Company retired assets in this subleased area as a result of this sublease with a net book value of $392 thousand, and recorded a loss on disposal of fixed assets for the same amount for the year ended December 31, 2013. The Company continues to maintain a $388 thousand letter of credit. The collateral for the letter of credit is recorded in other non-current assets on the balance sheet as of June 30, 2014.

Fair_Value_Measurements

Fair Value Measurements	6 Months Ended
	Jun. 30, 2014
Fair Value Measurements	'
	5. Fair Value Measurements
	The Company accounts for its financial assets and liabilities using fair value measurements. The accounting standard defines fair value, establishes a framework for measuring fair value under generally accepted accounting principles and enhances disclosures about fair value measurements. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The standard describes a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value which are the following:
		•		Level 1 - Quoted prices in active markets for identical assets or liabilities.
		•		Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.
		•		Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.
	Assets and liabilities measured at fair value on a recurring basis as of June 30, 2014 and December 31, 2013 are as follows:
	($ in thousands)				Fair Value Measurements at Reporting Date Using
	Description		Balance as of		Quoted Prices in		Significant Other		Significant
			June 30, 2014		Active Markets for		Observable Inputs		Unobservable Inputs
					Identical		(Level 2)		(Level 3)
					Assets/Liabilities
					(Level 1)
	Cash equivalents		$	51,689	$	51,689	$	—	$	—
	Warrant liability		$	6,094	$	—	$	6,094	$	—
	($ in thousands)				Fair Value Measurements at Reporting Date Using
	Description		Balance as of		Quoted Prices in		Significant Other		Significant
			December 31, 2013		Active Markets for		Observable Inputs		Unobservable
					Identical		(Level 2)		Inputs (Level 3)
					Assets/Liabilities
					(Level 1)
	Cash equivalents		$	66,974	$	66,974	$	—	$	—
	Warrant liability		$	11,776	$	—	$	11,776	$	—
	The cash equivalents represent deposits in a short term United States treasury money market mutual fund quoted in an active market and classified as a Level 1 asset. The Company’s Level 2 financial liabilities consist of long-term investor and placement agent warrants issued in connection with its December 2009 public offering. The warrants were valued using Binomial/Monte Carlo valuation models. See Note 9 for additional disclosures on the valuation methodology and significant assumptions.

Net_Loss_per_Share

Net Loss per Share	6 Months Ended
	Jun. 30, 2014
Net Loss per Share	'
	6. Net Loss per Share
	Basic net loss per share is computed by dividing net loss by the weighted average number of shares of common stock outstanding for the period. The Company’s potential dilutive shares, which include outstanding common stock options, unvested restricted stock and warrants, have not been included in the computation of diluted net loss per share for any of the periods presented as the result would be anti-dilutive. Such potential shares of common stock at June 30, 2014 and 2013 consist of the following:
		June 30,
		2014		2013
	Stock options		6,041,162		6,538,419
	Unvested restricted common stock		295,496		454,325
	Warrants		10,496,467		10,441,431
			16,833,125		17,434,175

Related_Party_Transactions

Related Party Transactions	6 Months Ended
	Jun. 30, 2014
Related Party Transactions	'
	7. Related Party Transactions
	On January 6, 2011, the Company entered into an Exclusive Channel Partner Agreement, or Channel Agreement, with Intrexon (see Note 7 to the financial statements, Commitments and Contingencies, for additional disclosure relating to the Channel Agreement). Our director, Randall J. Kirk, is the CEO, a director, and the largest stockholder of Intrexon. During the year ended December 31, 2012, the Company paid Intrexon approximately $11.4 million, of which $6.6 million was for services already incurred and the remaining $4.8 million was for services expected to be incurred within a year. This amount was included as part of prepaid expenses and other current assets on the balance sheet as of December 31, 2012. During the year ended December 31, 2013, the Company expensed $7.8 million for services performed by Intrexon, of which $4.8 million was applied to the prepaid balance in other current assets, $2.4 million was paid to Intrexon and $0.6 million was recorded in accrued expenses. As of December 31, 2013, the prepaid balance in other current assets on the accompanying balance sheet has been reduced to $0. During the six months ended June 30, 2014, the Company expensed $5.6 million for services performed by Intrexon, of which $2.2 million is included in accrued expenses at June 30, 2014.
	On January 25, 2012, Intrexon purchased 1,923,075 shares of common stock in the Company’s public offering.
	On November 7, 2012, the Company issued 3,636,926 shares of common stock to Intrexon under the terms of its Stock Purchase Agreement with Intrexon dated January 6, 2011.
	On October 13, 2013, Intrexon purchased 2,857,143 shares of common stock in the Company’s public offering.

Commitments_and_Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2014
Commitments and Contingencies	'
	8. Commitments and Contingencies
	Operating Leases
	Prior to December 31, 2012, the Company entered into an operating lease in New York, NY, consisting of 6,251 square feet of office space. In accordance with this agreement, the Company entered into a letter of credit in the amount of $388 thousand, naming the Company’s landlord as beneficiary. In January 2012, the Company amended the lease agreement, adding 1,008 square feet of office space. As of December 31, 2012, the Company occupied 7,259 square feet of space in New York, NY, and maintained a $388 thousand letter of credit. The collateral for the letter of credit is recorded in other non-current assets on the balance sheet as of December 31, 2012. The lease for office space in New York, NY expires in October 2018.
	On October 17, 2013, the Company entered into a sublease agreement to lease 7,259 square feet in the Company’s New York office to a subtenant. The Company remains primarily liable to pay rent on the original lease. The Company recorded a loss on the sublease in the amount of $729 thousand for the year ended December 31, 2013, representing the remaining contractual obligation of $2.3 million, less $1.6 million in payments from the subtenant. The Company retired assets in this subleased area as a result of this sublease with a net book value of $392 thousand, and recorded a loss on disposal of fixed assets for the same amount for the year ended December 31, 2013. The Company continues to maintain a $388 thousand letter of credit. The collateral for the letter of credit is recorded in other non-current assets on the balance sheet as of June 30, 2014. The lease and sublease for office space in New York, NY expires in October 2018.
	Prior to December 31, 2012, the Company entered into separate operating lease agreements for various spaces in a building in Boston, MA. That space consisted of 5,249 square feet on the first floor, 8,538 square feet on the second floor, and 6,959 square feet on the third floor. In June 2012, the Company re-negotiated a master lease for the entire Boston office space, added 9,800 square feet of office space on the fourth floor, surrendered 4,113 square feet from the second floor, and incorporated all floors’ lease agreements under the same master agreement expiring in August 2016. The Company provided an additional $41 thousand security deposit for the additional space on the fourth floor. As of December 31, 2012, a total security deposit of $127 thousand was paid to its landlord for security deposits for these agreements.
	On August 30, 2013, the Company entered into a sublease agreement to lease 5,249 square feet in the Company’s Boston office to a subtenant. The Company remains primarily liable to pay rent on the original lease. The Company recorded a loss on the sublease in the amount of $42 thousand for the year ended December 31, 2013, representing the remaining contractual obligation of $367 thousand, less $325 thousand in payments from the subtenant. The Company retired assets in this subleased area as a result of this sublease with a net book value of $194 thousand, and recorded a loss on disposal of fixed assets. In accordance with the sublease agreement, the subtenant provided the Company with a security deposit of $20 thousand, which is recorded in other non-current assets and other liabilities on the balance sheet on June 30, 2014. The sublease expires in August 2016.
	As of June 30, 2014, the Company occupies 21,184 square feet of space in its Boston, MA office and has paid a total of $127 thousand for security deposits, which are recorded in other non-current assets on the balance sheet.
	Total rent expense was approximately $305 thousand and $619 thousand for the six months ended June 30, 2014 and 2013, respectively.
	The Company records rent expense on a straight-line basis over the term of the lease. Accordingly, the Company has recorded a liability for deferred rent at June 30, 2014 and December 31, 2013 of $965 thousand ($235 thousand current and $730 thousand long-term) and $1.1 million ($212 thousand current and $851 thousand long-term), respectively, which is recorded in deferred rent on the balance sheet.
	License Agreements Patent and Technology License Agreement—The University of Texas M. D. Anderson Cancer Center and the Texas A&M University System.
	On August 24, 2004, the Company entered into a patent and technology license agreement with The Board of Regents of the University of Texas System, acting on behalf of The University of Texas M. D. Anderson Cancer Center and the Texas A&M University System, which the Company refers to, collectively, as the Licensors. Under this agreement, the Company was granted an exclusive, worldwide license to rights (including rights to U.S. and foreign patent and patent applications and related improvements and know-how) for the manufacture and commercialization of two classes of organic arsenicals (water- and lipid-based) for human and animal use. The class of water-based organic arsenicals includes darinaparsin.
	As partial consideration for the license rights obtained, the Company made an upfront payment in 2004 of $125 thousand and granted the Licensors 250,487 shares of the Company’s common stock. In addition, the Company issued options to purchase an additional 50,222 shares outside the 2003 Stock Option Plan for $0.002 per share following the successful completion of certain clinical milestones, which vested with respect to 12,555 shares upon the filing of an Investigation New Drug application, or IND, for darinaparsin in 2005 and vested with respect to another 25,111 shares upon the completion of dosing of the last patient for both Phase 1 clinical trials in 2007. The Company recorded $120 thousand of stock based compensation expense related to the vesting in 2007. The remaining 12,556 shares will vest upon enrollment of the first patient in a multi-center pivotal clinical trial i.e. a human clinical trial intended to provide the substantial evidence of efficacy necessary to support the filing of an approvable New Drug Application, or NDA. In addition, the Licensors are entitled to receive certain milestone payments, including $100 thousand that was paid in 2005 upon the commencement of Phase 1 clinical trial and $250 thousand that was paid in 2006 upon the dosing of the first patient in the Registrant-sponsored Phase 2 clinical trial for darinaparsin. The Company may be required to make additional payments upon achievement of certain other milestones in varying amounts which on a cumulative basis could total up to an additional $4.5 million. In addition, the Licensors are entitled to receive single digit percentage royalty payments on sales from a licensed product and will also be entitled to receive a portion of any fees that the Company may receive from a possible sublicense under certain circumstances. In addition, the Company also paid the Licensors $100 thousand in 2006 and 2007 to conduct scientific research with the Company obtaining exclusive right to all resulting intellectual property rights. The sponsored research agreements governing this research and any related extensions expired in February 2008 with no payments being made subsequent to that date.
	The license agreement also contains other provisions customary and common in similar agreements within the industry, such as the right to sublicense the Company rights under the agreement. On July 31, 2014, the Company amended and restated the License and Collaboration Agreement between the Company and Solasia Pharma K.K. or Solasia, granting to Solasia an exclusive worldwide license to develop and commercialize darinaparsin, and related organoarsenic molecules, in both intravenous and oral forms in all indications for human use. In exchange, the Company will be eligible to receive from Solasia development-and sales-based milestones, a royalty on net sales of darinaparsin, once commercialized, and a percentage of any sublicense revenues generated by Solasia. Solasia will be responsible for all costs related to the development, manufacturing and commercialization of darinaparsin. The Licensors will receive a portion of all milestone and royalty payments made by Solasia to the Company in accordance with the terms of the Company’s license agreement with the Licensors.
	The term of the license agreement between the Company and the Licensors extends until the expiration of all claims under patents and patent applications associated with the licensed technology, subject to earlier termination in the event of defaults by the Company or the Licensors under the license agreement, or if the Company becomes bankrupt or insolvent. No milestones under the license agreement were reached or expensed during the six months ended June 30, 2014 or during the years ended December 31, 2013, 2012 or 2011.
	License Agreement with DEKK-Tec, Inc.
	On October 15, 2004, the Company entered into a license agreement with DEKK-Tec, Inc., pursuant to which it was granted an exclusive, worldwide license for palifosfamide. As part of the signing of license agreement with DEKK-Tec, the Company expensed an upfront $50 thousand payment to DEKK-Tec in 2004.
	In consideration for the license rights, DEKK-Tec is entitled to receive payments upon achieving certain milestones in varying amounts which on a cumulative basis may total $4.0 million. Of the aggregate milestone payments, most will be creditable against future royalty payments as referenced below. The Company expensed a $100 thousand milestone payment upon achieving Phase 2 milestones during the year ended December 31, 2006. Additionally, in 2004 the Company issued DEKK-Tec an option to purchase 27,616 shares of the Company’s common stock for $0.02 per share. Upon the execution of the license agreement, 6,904 shares vested and were subsequently exercised in 2005 and the remaining options will vest upon certain milestone events, culminating with final FDA approval of the first NDA submitted by the Company (or by its sublicensee) for palifosfamide. DEKK-Tec is entitled to receive single digit percentage royalty payments on the sales of palifosfamide should it be approved for commercial sale. On March 16, 2010, the Company expensed a $100 thousand milestone payment upon receiving a United States Patent for palifosfamide. There were no payments made during 2009. In December 2010, the Company expensed a $300 thousand milestone payment and vested 6,904 stock options upon achieving Phase 3 milestones. These options were subsequently exercised in 2011. The Company’s obligation to pay royalties will terminate on a country-by-country basis upon the expiration of all valid claims of patents in such country covering licensed product, subject to earlier termination in the event of defaults by the parties under the license agreement. No milestones under the license agreement have been reached or expensed since 2010.
	Option Agreement with Southern Research Institute (“SRI”)
	On December 22, 2004, the Company entered into an Option Agreement with the Southern Research Institute, or SRI, pursuant to which the Company was granted an exclusive option to obtain an exclusive license to SRI’s interest in certain intellectual property, including exclusive rights related to certain isophosphoramide mustard analogs.
	Also on December 22, 2004, the Company entered into a Research Agreement with SRI pursuant to which the Company agreed to spend a sum not to exceed $200 thousand between the execution of the agreement and December 21, 2006, including a $25 thousand payment that was made simultaneously with the execution of the agreement, to fund research and development work by SRI in the field of isophosphoramide mustard analogs. The option agreement was exercised on February 13, 2007. Under the license agreement entered into upon exercise of the option, the Company is required to remit minimum annual royalty payments of $25 thousand until the first commercial sale of a licensed product. These payments were made for the years ended December 31, 2013, 2012, 2011, 2010, 2009 and 2008. Additionally, no payments have been made for the six months ended June 30, 2014. The Company may be required to make payments upon achievement of certain milestones in varying amounts which on a cumulative basis could total up to $775,000. In addition, SRI will be entitled to receive single digit percentage royalty payments on the sales of a licensed product in any country until all licensed patents rights in that country which are utilized in the product have expired. No milestones under the license agreement have been reached or expensed since the agreement’s inception.
	License Agreement with Baxter Healthcare Corporation
	On November 3, 2006, the Company entered into a definitive Asset Purchase Agreement for indibulin and a License Agreement to proprietary nanosuspension technology with affiliates of Baxter Healthcare S.A. The purchase included the entire indibulin intellectual property portfolio as well as existing drug substance and capsule inventories. The terms of the Asset Purchase Agreement included an upfront cash payment of approximately $1.1 million and an additional $100 thousand payment for existing inventory, both of which were expensed in 2006. In addition to the upfront costs, the Asset Purchase Agreement includes additional diligence and milestone payments that could amount to approximately $8 million in the aggregate and royalties on net sales of products covered by a valid claim of a patent for the life of the patent on a country-by-country basis. The Company expensed a $625 thousand milestone payment upon the successful U.S. IND application for indibulin in 2007. The term of the license agreement extends until the expiration of the last to expire of the patents covering the licensed products, subject to earlier termination in the event of defaults by the parties under the license agreement. No milestones under the license agreement were reached or expensed during the years ended December 31, 2011 or 2010. During each of the years ended December 31, 2013 and 2012, milestones of $250 thousand were reached and expensed. No milestones have been met during the six months ended June 30, 2014. In connection with the Company’s decision to focus on its synthetic biology programs, the Company will no longer pursue development of indibulin.
	Exclusive Channel Partner Agreement with Intrexon Corporation
	On January 6, 2011, the Company entered into an Exclusive Channel Partner Agreement, or the Channel Agreement, with Intrexon that governs a “channel partnering” arrangement in which the Company uses Intrexon’s technology directed towards in vivo expression of effectors in connection with the development of Ad-RTS-IL-12 + veledimex and DC-RTS-IL-12 + veledimex and generally to research, develop and commercialize products, in each case in which DNA is administered to humans for expression of anti-cancer effectors for the purpose of treatment or prophylaxis of cancer, which the Company collectively refers to as the Cancer Program. The Channel Agreement establishes committees comprised of representatives of ZIOPHARM and Intrexon that govern activities related to the Cancer Program in the areas of project establishment, chemistry, manufacturing and controls, clinical and regulatory matters, commercialization efforts and intellectual property.
	The Channel Agreement grants the Company a worldwide license to use patents and other intellectual property of Intrexon in connection with the research, development, use, importing, manufacture, sale, and offer for sale of products involving DNA administered to humans for expression of anti-cancer effectors for the purpose of treatment or prophylaxis of cancer, which the Company collectively refers to as the ZIOPHARM Products. Such license is exclusive with respect to any clinical development, selling, offering for sale or other commercialization of ZIOPHARM Products, and otherwise is non-exclusive. Subject to limited exceptions, the Company may not sublicense the rights described without Intrexon’s written consent.
	Under the Channel Agreement, and subject to certain exceptions, the Company is responsible for, among other things, the performance of the Cancer Program, including development, commercialization and certain aspects of manufacturing of ZIOPHARM Products. Intrexon is responsible for the costs of establishing manufacturing capabilities and facilities for the bulk manufacture of products developed under the Cancer Program, certain other aspects of manufacturing and costs of discovery-stage research with respect to platform improvements and costs of filing, prosecution and maintenance of Intrexon’s patents.
	Subject to certain expense allocations and other offsets provided in the Channel Agreement, the Company will pay Intrexon on a quarterly basis 50% of net profits derived in that quarter from the sale of ZIOPHARM Products, calculated on a ZIOPHARM Product-by- ZIOPHARM Product basis. The Company has likewise agreed to pay Intrexon on a quarterly basis 50% of revenue obtained in that quarter from a sublicensor in the event of a sublicensing arrangement. In addition, in partial consideration for each party’s execution and delivery of the Channel Agreement, the Company entered into a Stock Purchase Agreement with Intrexon.
	Following the first 24 months of the agreement, Intrexon had the option to terminate the Channel Agreement, if the Company failed to use diligent efforts to develop and commercialize ZIOPHARM Products or if the Company elected not to pursue the development of a Cancer Program identified by Intrexon that is a “Superior Therapy” as defined in the Channel Agreement. Also following the first 24 months of the agreement, the Company had the option to voluntarily terminate the Channel Agreement, upon 90 days written notice to Intrexon. The 24 month termination period expired during the year ended December 31, 2013.
	Upon termination of the Channel Agreement, the Company may continue to develop and commercialize any ZIOPHARM Product that, at the time of termination:
		•	Is being commercialized by the Company;
		•	Has received regulatory approval;
		•	Is a subject of an application for regulatory approval that is pending before the applicable regulatory authority; or
		•	Is the subject of at least an ongoing Phase 2 clinical trial (in the case of a termination by Intrexon due to an uncured breach or a voluntary termination by the Company), or an ongoing Phase 1 clinical trial in the field (in the case of a termination by the Company due to an uncured breach or a termination by Intrexon following an unconsented assignment by the Company or the Company’s election not to pursue development of a Superior Therapy).
	The Company’s obligation to pay 50% of net profits or revenue described above with respect to these “retained” products will survive termination of the Channel Agreement.
	Collaboration Agreement with Harmon Hill, LLC
	On April 8, 2008, the Company signed a collaboration agreement for Harmon Hill, LLC, or Harmon Hill, to provide consulting and other services for the development and commercialization of oncology therapeutics by ZIOPHARM. Under the agreement the Company has agreed to pay Harmon Hill $20 thousand per month for the consulting services and has further agreed to pay Harmon Hill (a) $500 thousand upon the first patient dosing of the Specified Drug, as defined in the collaboration agreement, in a pivotal trial, which trial uses a dosing Regime introduced by Harmon Hill; and (b) provided that the Specified Drug receives regulatory approval from the FDA, the European Medicines Agency or another regulatory agency for the marketing of the Specified Drug, a 1% royalty of the Company’s net sales will be awarded to Harmon Hill.
	If the Specified Drug is sublicensed to a third party, the agreement entitles Harmon Hill to 1% award of royalties or other payments received from a sublicense. Subject to renewal or extension by the parties, the term of the agreement was for a one year period that expired April 8, 2009. Following such expiration, the parties continued to operate under the terms of the agreement and during 2010, the agreement was formally extended through April 8, 2011 and again through April 8, 2012. The agreement was extended through November 8, 2012 and has now expired. The Company expensed $240 thousand during the years ended December 31, 2011 and 2010 and expensed $200 thousand during the year ended December 31, 2012 for consulting services per the aforementioned agreement. No milestones under the collaboration agreement were reached or expensed during the years ended December 31, 2013, 2012, 2011 or 2010.
	On June 27, 2013, the Company signed a new collaboration agreement with Harmon Hill to provide consulting and other services for the development and commercialization of oncology therapeutics by ZIOPHARM, effective April 1, 2013. Under the agreement the Company has agreed to pay Harmon Hill $15 thousand per month for the consulting services. Subject to renewal or extension by the parties, the term of the agreement is for a one year period. The Company expensed $135 thousand for the year ended December 31, 2013. The Company expensed $90 thousand for the six months ended June 30, 2014.
	Collaboration Agreement with Solasia Pharma K.K.
	On March 7, 2011, the Company entered into a License and Collaboration Agreement with Solasia Pharma K.K., or Solasia.
	Pursuant to the License and Collaboration Agreement, the Company granted Solasia an exclusive license to develop and commercialize darinaparsin in both IV and oral forms and related organic arsenic molecules, in all indications for human use in a pan- Asian/Pacific territory comprised of Japan, China, Hong Kong, Macau, Republic of Korea, Taiwan, Singapore, Australia, New Zealand, Malaysia, Indonesia, Philippines and Thailand.
	As consideration for the license, the Company received an upfront payment of $5.0 million to be used exclusively for further clinical development of darinaparsin outside of the pan-Asian/Pacific territory, and will be entitled to receive additional payments of up to $32.5 million in development-based milestones and up to $53.5 million in sales-based milestones. The Company will also be entitled to receive double digit royalty payments from Solasia based upon net sales of licensed products in the applicable territories, once commercialized, and a percentage of sublicense revenues generated by Solasia. Under the License and Collaboration Agreement, the Company provides Solasia with drug product to conduct clinical trials. These transfers are accounted for as a reduction of research and development costs and an increase in collaboration receivables. The agreement provides that Solasia will be responsible for the development and commercialization of darinaparsin in the pan-Asian/Pacific territory.
	On July 31, 2014, the Company entered into an amendment and restatement of the License and Collaboration Agreement granting Solasia an exclusive worldwide license to develop and commercialize darinaparsin, and related organoarsenic molecules, in both intravenous and oral forms in all indications for human use. In exchange, the Company will be eligible to receive from Solasia development-and sales-based milestones, a royalty on net sales of darinaparsin, once commercialized, and a percentage of any sublicense revenues generated by Solasia. Solasia will be responsible for all costs related to the development, manufacturing and commercialization of darinaparsin. The Company’s Licensors will receive a portion of all milestone and royalty payments made by Solasia to the Company in accordance with the terms of the Company’s license agreement with the Licensors.
	The upfront payment for research and development funding is earned over the period of effort. The Company originally estimated this period to be 75 months. In accordance with the amended and restated License and Collaboration Agreement with Solasia, the Company is no longer obligated to continue their research and development efforts in connection with the upfront payment. Accordingly, the remaining deferred revenue of $2.3 million at June 30, 2014 has been classified as current.
	CRO Services Agreement with PPD Development, L. P.
	The Company is party to a Master Clinical Research Organization Services Agreement with PPD Development, L. P., or PPD, dated January 29, 2010, a related work order dated June 25, 2010 and a related work order dated April 8, 2011 under which PPD provides clinical research organization, or CRO, services in support of the Company’s clinical trials. PPD is entitled to cumulative payments of up to $20.0 million under these arrangements, which is payable by the Company in varying amounts upon PPD achieving specified milestones. During the year ended December 31, 2010, the Company expensed $1.8 million upon contract execution and $1.1 million upon a clinical study commencement of enrollment in North America. During the year ended December 31, 2011, additional milestones related to commencing enrollment in Europe, Latin America and Asia along with enrollment based milestones were met and the Company recorded an aggregate $4.0 million expense. During the year ended December 31, 2012, additional enrollment-based and contract modification milestones were met and expensed totaling $3.8 million. During the year ended December 31, 2013, patient progression and data based milestones totaling $9.2 million were met and expensed. There are no remaining milestones on this agreement.
	CRO Services Agreement with Pharmaceutical Research Associates, Inc.
	On December 13, 2011, the Company entered into a Master Clinical Research Organization Services Agreement with Pharmaceutical Research Associates, Inc., or PRA, under which PRA provides CRO services in support of our clinical trials. PRA is entitled to cumulative payments of up to $9.5 million under these arrangements, which is payable by the Company in varying amounts upon PRA achieving specified milestones. During the year ended December 31, 2012, the Company expensed $7.3 million upon the achievement of various letter of intent and enrollment-based milestones. During the year ended December 31, 2013, contract modification and patient enrollment based milestones totaling $2.2 million were met and expensed. There are no remaining milestones on this agreement.
	CRO Services Agreement with Novella Clinical, Inc.
	On December 4, 2008, the Company entered into a Master Clinical Research Organization Services Agreement with Novella Clinical, Inc., or Novella, under which PRA provides CRO services in support of our clinical trials. The work order for the newest trial being conducted by Novella was signed on November 2, 2012. Novella is entitled to cumulative payments of up to $790 thousand under these arrangements, which is payable in varying amounts upon Novella achieving specified milestones. During the year ended December 31, 2012, the Company expensed $256 thousand upon the achievement of various milestones. During the year ended December 31, 2013, two database related milestones and one site activation related milestone were met and expensed totaling $136 thousand. During the six months ended June 30, 2014, one clinical milestone was met and expensed totaling $10 thousand.

Warrants

Warrants	6 Months Ended
	Jun. 30, 2014
Warrants	'
	9. Warrants
	The Company has issued both warrants that are accounted for as liabilities and warrants that are accounted for as equity instruments.
	The Company follows accounting standards that provide guidance in assessing whether an equity-issued financial instrument is indexed to an entity’s own stock for purposes of determining whether a financial instrument should be treated as a derivative and classified as a liability. Accounting standards require that liability classified warrants be recorded at their fair value at each financial reporting period and the resulting gain or loss be recorded as other income (expense) in the Statements of Operations. Fair value is measured using the binomial valuation model.
	The number of warrants outstanding at June 30, 2014 and December 31, 2013 were as follows:
		June 30,			December 31,
		2014			2013
	Liability-classified warrants		8,235,076			8,235,076
	Equity-classified warrants		2,261,391			2,304,691
	Total warrants		10,496,467			10,539,767
	Liability-Classified Warrants
	In connection with its December 2009 public securities offering, the Company issued warrants to purchase an aggregate of 8,206,520 shares of common stock (including the investor warrants and 464,520 warrants issued to the underwriters for the offering) (the “2009 Warrants”). The 2009 Warrants issued to investors were exercisable immediately and the warrants issued to underwriters became exercisable six months after the date of issuance. The 2009 Warrants have an exercise price of $4.02 per share and have a five-year term. The fair value of the 2009 Warrants was estimated at $22.9 million using a Black-Scholes model with the following assumptions: expected volatility of 105%, risk free interest rate of 2.14%, expected life of five years and no dividends.
	Subject to certain exceptions, these warrants provide for anti-dilution protection should common stock or common stock equivalents be subsequently issued at a price less than the exercise price of the warrants then in effect, which was initially $4.02 per share. This provision was triggered in 2013 when stock was sold at $3.50 per share in our 2013 public offering. Accordingly, the shares of the Company’s common stock underlying the outstanding 2009 Warrants were increased by 184,367 shares to 8,235,076 shares, and the exercise price of the 2009 Warrants was decreased to $3.93.
	The Company assessed whether the 2009 Warrants require accounting as derivatives. The Company determined that these warrants were not indexed to the Company’s own stock in accordance with accounting standards codification Topic 815, Derivatives and Hedging. As such, the Company has concluded these warrants did not meet the scope exception for determining whether the instruments require accounting as derivatives and were classified as liabilities.
	The Company uses the Binomial/Monte Carlo pricing model to estimate the value of the liability-classified warrants. The following assumptions were used in the Binomial/Monte Carlo valuation model at June 30, 2014 and 2013:
		June 30, 2014			June 30, 2013
	Risk-free interest rate		0.06	%		0.26	%
	Expected life in years		0.44			1.44
	Expected volatility		70	%		70	%
	Expected dividend yield		0			0
	Steps per year		54			12
	The change in the fair value of the warrant liability resulted in a gain of $5.6 million and $5.7 million for the three and six months ended June 30, 2014, respectively. The change in the fair value of the warrant liability resulted in a loss of $0.4 million and a gain of $10.4 million for the three and six months ended June 30, 2013. The change in the fair value of the warrant liability was charged to other income (expense) in the Statements of Operations.
	During the six months ended June 30, 2014, warrant exercises were as follows:
	(in thousands, except share data)	Equity			Liability			Common		Liability		Cash
		Warrants			Warrants			Stock		Reclassed		Received
								Issued		to Equity
	Cash exercises		—			—			—	$	—	$	—
	Cashless exercises		43,300			—			21,977		—		—
			43,300			—			21,977	$	—	$	—
	During the six months ended June 30, 2013, warrant exercises were as follows:
	(in thousands, except share data)	Equity			Liability			Common		Liability		Cash
		Warrants			Warrants			Stock		Reclassed		Received
								Issued		to Equity
	Cash exercises		49,315			—			49,315	$	—	$	101
	Cashless exercises		—			—			—		—		—
			49,315			—			49,315	$	—	$	101

Common_Stock

Common Stock	6 Months Ended
	Jun. 30, 2014
Common Stock	'
	10. Common Stock
	On October 23, 2013, the Company entered into an underwriting agreement with J. P. Morgan Securities LLC, as representative of the several underwriters named therein, relating to the issuance and sale of 14,300,000 shares of our common stock. The price to the public in the offering was $3.50 per share, and the underwriters agreed to purchase the shares from the Company pursuant to the underwriting agreement at a purchase price of $3.29 per share. Under the terms of the underwriting agreement, the Company also granted the underwriters an option, exercisable for 30 days, to purchase up to an additional 2,145,000 shares of common stock at a purchase price of $3.29 per share, and the underwriters elected to exercise such option in full. The offering was made pursuant to the Company’s effective registration statement on Form S-3 (Registration Statement No. 333-177793) previously filed with the SEC, and a prospectus supplement thereunder. The underwriters purchased the 14,300,000 shares and the additional 2,145,000 shares on October 29, 2013. The net proceeds from the offering were approximately $53.9 million after deducting underwriting discounts and estimated offering expenses payable by the Company.

StockBased_Compensation

Stock-Based Compensation	6 Months Ended
	Jun. 30, 2014
Stock-Based Compensation	'
	11. Stock-Based Compensation
	The Company recognized stock-based compensation expense on all employee and non-employee awards as follows:
		For the three months						For the six months
		ended June 30,						ended June 30,
	(in thousands)	2014			2013			2014		2013
	Research and development	$	410		$	(145	)	$	786	$	392
	General and administrative		802			277			1,649		1,281
	Stock-based employee compensation expense	$	1,212		$	132		$	2,435	$	1,673
	The Company granted 23,800 and 104,300 stock options during the three and six months ended June 30, 2014 that had a weighted-average grant date fair value of $2.84 and $3.23 per share, respectively. The Company granted 1,315,500 and 1,426,400 stock options during the three and six months ended June 30, 2013 that had a weighted-average grant date fair value of $1.77 and $1.89 per share, respectively.
	At June 30, 2014, total unrecognized compensation costs related to unvested stock options outstanding amounted to $6.2 million. The cost is expected to be recognized over a weighted-average period of 1.59 years.
	On May 31, 2013, the Company extended the contractual life of 66,667 fully vested stock options held by one employee from 3 to 12 months.
	On June 14, 2013, the Company extended the contractual life of 71,167 fully vested stock options held by one employee from 3 to 12 months.
	On March 31, 2014, the Company extended the contractual life of 71,167 fully vested stock options held by one employee by an additional 9 months.
	For the three months ended June 30, 2014 and 2013, the fair value of stock options was estimated on the date of grant using a Black-Scholes option valuation model with the following assumptions:
		For the three months ended June 30,
		2014			2013
	Risk-free interest rate		1.98	%		1.65	%
	Expected life in years		6			6
	Expected volatility		94.07	%		95.45	%
	Expected dividend yield		0			0
	Stock option activity under the Company’s stock option plan for the six months ended June 30, 2014 is as follows:
	(in thousands, except share and per share data)	Number of			Weighted-			Weighted-		Aggregate
		Shares			Average Exercise			Average		Intrinsic Value
					Price			Contractual
								Term (Years)
	Outstanding, December 31, 2013		6,747,302		$	3.81
	Granted		104,300			3.54
	Exercised		(583,038	)		2.26
	Cancelled		(227,402	)		5.05
	Outstanding, June 30, 2014		6,041,162		$	3.91			7.24	$	4,456
	Vested and unvested expected to vest at June 30, 2014		5,988,240		$	4.11			5.61	$	4,417
	Options exercisable, June 30, 2014		3,176,594		$	4.11			5.61	$	1,846
	Options exercisable, December 31, 2013		3,471,935		$	4.01			5.03	$	2,654
	Options available for future grant		5,317,831
	A summary of the status of unvested restricted stock for the six months ended June 30, 2014 is as follows:
		Number of Shares			Weighted-Average
					Grant Date Fair Value
	Non-vested, December 31, 2013		352,865		$	4.38
	Granted		—			—
	Vested		(48,433	)		4.51
	Cancelled		(8,936	)		4.41
	Non-vested, June 30, 2014		295,496		$	4.36
	At June 30, 2014, total unrecognized compensation costs related to unvested restricted stock outstanding amounted to $0.7 million. The cost is expected to be recognized over a weighted-average period of 1.09 years.

Fair_Value_Measurements_Tables

Fair Value Measurements (Tables)	6 Months Ended
	Jun. 30, 2014
Assets and Liabilities Measured at Fair Value on Recurring Basis	'
	Assets and liabilities measured at fair value on a recurring basis as of June 30, 2014 and December 31, 2013 are as follows:
	($ in thousands)			Fair Value Measurements at Reporting Date Using
	Description	Balance as of		Quoted Prices in		Significant Other		Significant
		June 30, 2014		Active Markets for		Observable Inputs		Unobservable Inputs
				Identical		(Level 2)		(Level 3)
				Assets/Liabilities
				(Level 1)
	Cash equivalents	$	51,689	$	51,689	$	—	$	—
	Warrant liability	$	6,094	$	—	$	6,094	$	—
	($ in thousands)			Fair Value Measurements at Reporting Date Using
	Description	Balance as of		Quoted Prices in		Significant Other		Significant
		December 31, 2013		Active Markets for		Observable Inputs		Unobservable
				Identical		(Level 2)		Inputs (Level 3)
				Assets/Liabilities
				(Level 1)
	Cash equivalents	$	66,974	$	66,974	$	—	$	—
	Warrant liability	$	11,776	$	—	$	11,776	$	—

Net_Loss_per_Share_Tables

Net Loss per Share (Tables)	6 Months Ended
	Jun. 30, 2014
Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share	'
	The Company’s potential dilutive shares, which include outstanding common stock options, unvested restricted stock and warrants, have not been included in the computation of diluted net loss per share for any of the periods presented as the result would be anti-dilutive. Such potential shares of common stock at June 30, 2014 and 2013 consist of the following:
		June 30,
		2014		2013
	Stock options		6,041,162		6,538,419
	Unvested restricted common stock		295,496		454,325
	Warrants		10,496,467		10,441,431
			16,833,125		17,434,175

Warrants_Tables

Warrants (Tables)	6 Months Ended
	Jun. 30, 2014
Number of Warrants Outstanding	'
	The number of warrants outstanding at June 30, 2014 and December 31, 2013 were as follows:
		June 30,			December 31,
		2014			2013
	Liability-classified warrants		8,235,076			8,235,076
	Equity-classified warrants		2,261,391			2,304,691
	Total warrants		10,496,467			10,539,767
Assumptions Used in Binomial and Monte Carlo Valuation Model	'
	The following assumptions were used in the Binomial/Monte Carlo valuation model at June 30, 2014 and 2013:
		June 30, 2014			June 30, 2013
	Risk-free interest rate		0.06	%		0.26	%
	Expected life in years		0.44			1.44
	Expected volatility		70	%		70	%
	Expected dividend yield		0			0
	Steps per year		54			12
Warrant Exercises	'
	During the six months ended June 30, 2014, warrant exercises were as follows:
	(in thousands, except share data)	Equity			Liability			Common		Liability		Cash
		Warrants			Warrants			Stock		Reclassed		Received
								Issued		to Equity
	Cash exercises		—			—			—	$	—	$	—
	Cashless exercises		43,300			—			21,977		—		—
			43,300			—			21,977	$	—	$	—
	During the six months ended June 30, 2013, warrant exercises were as follows:
	(in thousands, except share data)	Equity			Liability			Common		Liability		Cash
		Warrants			Warrants			Stock		Reclassed		Received
								Issued		to Equity
	Cash exercises		49,315			—			49,315	$	—	$	101
	Cashless exercises		—			—			—		—		—
			49,315			—			49,315	$	—	$	101

StockBased_Compensation_Tables

Stock-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2014
Stock-Based Compensation Expense on All Employee and Non-Employee Awards	'
	The Company recognized stock-based compensation expense on all employee and non-employee awards as follows:
		For the three months						For the six months
		ended June 30,						ended June 30,
	(in thousands)	2014			2013			2014		2013
	Research and development	$	410		$	(145	)	$	786	$	392
	General and administrative		802			277			1,649		1,281
	Stock-based employee compensation expense	$	1,212		$	132		$	2,435	$	1,673
Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model	'
	For the three months ended June 30, 2014 and 2013, the fair value of stock options was estimated on the date of grant using a Black-Scholes option valuation model with the following assumptions:
		For the three months ended June 30,
		2014			2013
	Risk-free interest rate		1.98	%		1.65	%
	Expected life in years		6			6
	Expected volatility		94.07	%		95.45	%
	Expected dividend yield		0			0
Stock Option Activity Under Stock Option Plan	'
	Stock option activity under the Company’s stock option plan for the six months ended June 30, 2014 is as follows:
	(in thousands, except share and per share data)	Number of			Weighted-			Weighted-		Aggregate
		Shares			Average Exercise			Average		Intrinsic Value
					Price			Contractual
								Term (Years)
	Outstanding, December 31, 2013		6,747,302		$	3.81
	Granted		104,300			3.54
	Exercised		(583,038	)		2.26
	Cancelled		(227,402	)		5.05
	Outstanding, June 30, 2014		6,041,162		$	3.91			7.24	$	4,456
	Vested and unvested expected to vest at June 30, 2014		5,988,240		$	4.11			5.61	$	4,417
	Options exercisable, June 30, 2014		3,176,594		$	4.11			5.61	$	1,846
	Options exercisable, December 31, 2013		3,471,935		$	4.01			5.03	$	2,654
	Options available for future grant		5,317,831
Summary of Unvested Restricted Stock	'
	A summary of the status of unvested restricted stock for the six months ended June 30, 2014 is as follows:
		Number of Shares			Weighted-Average
					Grant Date Fair Value
	Non-vested, December 31, 2013		352,865		$	4.38
	Granted		—			—
	Vested		(48,433	)		4.51
	Cancelled		(8,936	)		4.41
	Non-vested, June 30, 2014		295,496		$	4.36

Business_Additional_Informatio

Business - Additional Information (Detail) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Nature Of Operations [Line Items]	'	'
Accumulated deficit	($356,118)	($340,831)

Restructuring_Additional_Infor

Restructuring - Additional Information (Detail) (USD $)	3 Months Ended				0 Months Ended	12 Months Ended	0 Months Ended	12 Months Ended
	Jun. 30, 2013	Apr. 03, 2013	Apr. 03, 2013	Apr. 03, 2013	Aug. 30, 2013	Dec. 31, 2013	Oct. 17, 2013	Dec. 31, 2013	Jun. 30, 2014	Dec. 31, 2012	Dec. 31, 2011
		Position	Filled positions	Unfilled positions	Boston, MA	Boston, MA	New York, NY	New York, NY	New York, NY	New York, NY	New York, NY
			Position	Position	sqft		sqft
Restructuring Cost and Reserve [Line Items]	'	'	'	'	'	'	'	'	'	'	'
Total charges incurred related to workforce reduction	$1,700,000	'	'	'	'	'	'	'	'	'	'
Number of positions eliminated	'	65	40	25	'	'	'	'	'	'	'
Area under sublease agreement	'	'	'	'	5,249	'	7,259	'	'	'	'
Loss on sublease	'	'	'	'	'	42,000	'	729,000	'	'	'
Remaining contractual obligation	'	'	'	'	'	367,000	'	2,300,000	'	'	'
Sublease revenue from subtenant	'	'	'	'	'	325,000	'	1,600,000	'	'	'
Loss on disposal of fixed assets	'	'	'	'	'	-194,000	'	-392,000	'	'	'
Letter of credit	'	'	'	'	'	'	'	'	$388,000	$388,000	$388,000

Assets_and_Liabilities_Measure

Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) (Fair Value, Measurements, Recurring, USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]	'	'
Cash equivalents	$51,689	$66,974
Warrant liability	6,094	11,776
Quoted Prices in Active Markets for Identical Assets/Liabilities (Level 1)	'	'
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]	'	'
Cash equivalents	51,689	66,974
Significant Other Observable Inputs (Level 2)	'	'
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]	'	'
Warrant liability	$6,094	$11,776

Potential_Dilutive_Shares_Excl

Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail)	6 Months Ended
	Jun. 30, 2014	Jun. 30, 2013
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Antidilutive securities excluded from computation of earnings per share, amount	16,833,125	17,434,175
Stock Option	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Antidilutive securities excluded from computation of earnings per share, amount	6,041,162	6,538,419
Restricted Stock	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Antidilutive securities excluded from computation of earnings per share, amount	295,496	454,325
Warrants	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Antidilutive securities excluded from computation of earnings per share, amount	10,496,467	10,441,431

Related_Party_Transactions_Add

Related Party Transactions - Additional Information (Detail) (USD $)	0 Months Ended			6 Months Ended	12 Months Ended
	Oct. 13, 2013	Nov. 07, 2012	Jan. 25, 2012	Jun. 30, 2014	Dec. 31, 2013	Dec. 31, 2012
Related Party Transaction [Line Items]	'	'	'	'	'	'
Prepaid expenses and other current assets	'	'	'	$991,000	$1,948,000	'
Intrexon Corporation	'	'	'	'	'	'
Related Party Transaction [Line Items]	'	'	'	'	'	'
Payments for services	'	'	'	5,600,000	2,400,000	11,400,000
Amounts paid for services incurred	'	'	'	'	7,800,000	6,600,000
Prepaid expenses and other current assets	'	'	'	'	0	4,800,000
Accrued expense	'	'	'	$2,200,000	$600,000	'
Stock issued during period	2,857,143	3,636,926	1,923,075	'	'	'

Commitments_and_Contingencies_

Commitments and Contingencies - Additional Information (Detail) (USD $)

3 Months Ended

6 Months Ended

12 Months Ended

0 Months Ended

12 Months Ended

12 Months Ended

12 Months Ended

12 Months Ended

1 Months Ended

12 Months Ended

0 Months Ended

6 Months Ended

12 Months Ended

24 Months Ended

6 Months Ended

0 Months Ended

12 Months Ended

12 Months Ended

12 Months Ended

6 Months Ended

12 Months Ended

12 Months Ended

0 Months Ended

6 Months Ended

12 Months Ended

0 Months Ended

6 Months Ended

0 Months Ended

12 Months Ended

0 Months Ended

12 Months Ended

Jun. 30, 2014

Jun. 30, 2013

Jun. 30, 2014

Jun. 30, 2013

Dec. 31, 2013

Aug. 24, 2004

Dec. 31, 2007

Dec. 31, 2004

Jun. 30, 2014

Dec. 31, 2005

Dec. 31, 2006

Dec. 31, 2007

Dec. 31, 2006

Dec. 31, 2005

Dec. 31, 2007

Jun. 30, 2014

Dec. 31, 2004

Dec. 31, 2005

Dec. 31, 2004

Oct. 15, 2004

Dec. 31, 2006

Dec. 31, 2010

Dec. 31, 2011

Mar. 16, 2010

Oct. 15, 2004

Jun. 30, 2014

Dec. 31, 2013

Dec. 31, 2012

Dec. 31, 2011

Dec. 31, 2010

Dec. 31, 2009

Dec. 31, 2008

Dec. 21, 2006

Dec. 21, 2006

Jun. 30, 2014

Jan. 06, 2011

Jan. 29, 2010

Dec. 31, 2011

Dec. 31, 2010

Dec. 31, 2010

Dec. 31, 2012

Dec. 31, 2013

Dec. 31, 2011

Dec. 31, 2013

Dec. 31, 2012

Nov. 02, 2012

Dec. 31, 2012

Jun. 30, 2014

Dec. 31, 2013

Nov. 03, 2006

Dec. 31, 2007

Nov. 03, 2006

Jun. 27, 2013

Jun. 30, 2014

Dec. 31, 2013

Dec. 31, 2012

Dec. 31, 2011

Dec. 31, 2010

Apr. 08, 2008

Jun. 27, 2013

Apr. 08, 2008

Mar. 07, 2011

Jun. 30, 2014

Jun. 30, 2014

Oct. 17, 2013

Dec. 31, 2013

Dec. 31, 2012

Jun. 30, 2014

Jan. 31, 2012

Dec. 31, 2011

Aug. 30, 2013

Dec. 31, 2013

Dec. 31, 2011

Jun. 30, 2014

Dec. 31, 2012

Dec. 31, 2011

Jun. 30, 2012

Dec. 31, 2011

Dec. 31, 2011

Jun. 30, 2012

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

The University of Texas M.D. Anderson Cancer Center and The Texas A & M University System

DEKK Tec Inc

DEKK Tec Inc

DEKK Tec Inc

DEKK Tec Inc

DEKK Tec Inc

DEKK Tec Inc

DEKK Tec Inc

DEKK Tec Inc

Southern Research Institute

Southern Research Institute

Southern Research Institute

Southern Research Institute

Southern Research Institute

Southern Research Institute

Southern Research Institute

Southern Research Institute

Southern Research Institute

Intrexon Corporation

Intrexon Corporation

PPD Development L. P.

PPD Development L. P.

PPD Development L. P.

PPD Development L. P.

PPD Development L. P.

PPD Development L. P.

Pharmaceutical Research Associates Inc

Pharmaceutical Research Associates Inc

Pharmaceutical Research Associates Inc

Novella Clinical, Inc.

Novella Clinical, Inc.

Novella Clinical, Inc.

Novella Clinical, Inc.

Baxter Healthcare Corporation

Baxter Healthcare Corporation

Baxter Healthcare Corporation

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Harmon Hill LLC

Solasia

Solasia

Solasia

New York, NY

New York, NY

New York, NY

New York, NY

New York, NY

New York, NY

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Boston, MA

Patent

Upon the commencement of Phase 1 clinical trial

Upon the dosing of the first patient

Intellectual Property Rights

Intellectual Property Rights

Upon the filing of an Investigation New Drug application (IND) for darinaparsin

Upon the completion of dosing of the last patient for both Phase 1 clinical trials

Upon enrollment of the first patient in a multi-center pivotal clinical trial

Up Front Payment

Upon the dosing of the first patient

Phase 3

Phase 3

Upon receiving a United States Patent for palifosfamide

Up Front Payment

Execution Agreement

Maximum

Quarterly Payment

Upon contract execution

Upon contract execution

Upon a clinical study commencement of enrollment in North America

Upon initial clinical study enrollment

Upon the achievement of various milestones

Upon the achievement of various milestones

Upon the achievement of various milestones

Upon the achievement of various milestones

Upon two database related milestones

Upon two database related milestones

Upon the successful U.S. IND application for indibulin

Royalty Payments

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Collaboration Agreement

Development-based milestones

Sales-based milestones

sqft

sqft

sqft

sqft

sqft

sqft

The first floor

The second floor

The second floor

The third floor

The four floor

Upon the dosing of the first patient

Monthly Payment

Monthly Payment

sqft

sqft

sqft

sqft

sqft

Commitments and Contingencies Disclosure [Line Items]

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Office space under operating lease

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

7,259

'

'

6,251

'

'

'

21,184

'

'

4,113

'

'

9,800

Letter of credit

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

$388,000

$388,000

'

$388,000

'

'

'

'

'

'

'

'

'

'

Additional office space under operating lease

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

1,008

'

'

'

'

'

'

'

'

'

'

'

Operating lease expiration month and year

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'2018-10

'2018-10

'

'

'

'

'

'2016-08

'

'

'

'

'

'

'

Area under sublease agreement

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

7,259

'

'

'

'

'

5,249

'

'

'

'

'

'

'

'

'

Loss on sublease

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

729,000

'

'

'

'

'

42,000

'

'

'

'

'

'

'

'

Remaining contractual obligation

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

2,300,000

'

'

'

'

'

367,000

'

'

'

'

'

'

'

'

Sublease revenue from subtenant

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

1,600,000

'

'

'

'

'

325,000

'

'

'

'

'

'

'

'

Loss on disposal of fixed assets

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

-392,000

'

'

'

'

'

-194,000

'

'

'

'

'

'

'

'

Operating lease space

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

5,249

'

8,538

6,959

'

Security deposits

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

127,000

127,000

'

'

'

'

41,000

Security deposit from subtenant

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

20,000

'

'

'

'

'

'

Total rent Expense

'

'

305,000

619,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Deferred rent-current portion

235,000

'

235,000

'

212,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Deferred rent-non-current portion

730,000

'

730,000

'

851,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Deferred rent liability net

965,000

'

965,000

'

1,100,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Number of products

'

'

'

'

'

2

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Licensing fee

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

125,000

'

'

'

'

'

'

'

50,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Stock options, granted

23,800

1,315,500

104,300

1,426,400

'

'

'

250,487

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Option to purchase common stock

'

'

'

'

'

'

'

50,222

'

'

'

'

'

'

'

'

'

'

27,616

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Sale of stock price per share

'

'

'

'

'

'

'

$0.00

'

'

'

'

'

'

'

'

'

'

$0.02

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Shares vested

'

'

'

'

'

'

'

'

'

'

'

'

'

12,555

25,111

'

'

'

6,904

'

'

6,904

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Stock-based compensation

1,212,000

132,000

2,435,000

1,673,000

'

'

120,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Shares expected to vest

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

12,556

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Milestone payment

'

'

'

'

'

'

'

'

'

100,000

250,000

100,000

100,000

'

'

'

'

'

'

'

100,000

300,000

'

100,000

'

'

'

'

'

'

'

'

'

'

'

'

'

4,000,000

1,800,000

1,100,000

3,800,000

9,200,000

'

2,200,000

7,300,000

'

256,000

10,000

136,000

'

625,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Milestone maximum payment

'

'

'

'

'

'

'

'

4,500,000

'

'

'

'

'

'

'

'

'

'

4,000,000

'

'

'

'

'

775,000

'

'

'

'

'

'

'

'

'

'

20,000,000

'

'

'

'

'

9,500,000

'

'

790,000

'

'

'

'

'

8,000,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Shares exercised

'

'

583,038

'

'

'

'

'

'

'

'

'

'

'

'

'

'

6,904

'

'

'

'

6,904

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Research expenses

8,346,000

14,775,000

14,888,000

33,887,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

25,000

200,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Royalty payment

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

0

25,000

25,000

25,000

25,000

25,000

25,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Asset Purchase Agreement, upfront cash payment

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

1,100,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Asset Purchase Agreement, additional cash payment for existing inventory

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

100,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Percent of company net profit

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

50.00%

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

1.00%

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Percentage of revenue agreed to pay which is obtained from sublicensor

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

50.00%

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Contract termination description

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'The Company's obligation to pay 50% of net profits or revenue described above with respect to these "retained" products will survive termination of the Channel Agreement.

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Other expense

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

90,000

135,000

200,000

240,000

240,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Payment for consulting services fee

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

500,000

15,000

20,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Milestones under the license agreement expense

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

0

0

0

0

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Agreement term

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'1 year

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Upfront payment received

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

5,000,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Expected Additional milestone payments to be received

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

32,500,000

53,500,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Deferred revenue - current portion

$2,333,000

'

$2,333,000

'

$800,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Estimated upfront payment for research and development funding earning period

'

'

'

'

'75 months

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Number_of_Warrants_Outstanding

Number of Warrants Outstanding (Detail)	Jun. 30, 2014	Dec. 31, 2013
Class of Warrant or Right [Line Items]	'	'
Warrant outstanding	10,496,467	10,539,767
Liability	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant outstanding	8,235,076	8,235,076
Equity	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant outstanding	2,261,391	2,304,691

Warrants_Additional_Informatio

Warrants - Additional Information (Detail) (USD $)	3 Months Ended		6 Months Ended		12 Months Ended		6 Months Ended	12 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013	Dec. 31, 2009	Dec. 31, 2013	Jun. 30, 2014	Dec. 31, 2013	Dec. 31, 2009	Dec. 31, 2013
							Liability	Liability	J. P. Morgan Securities LLC	Registered direct offering
Class of Warrant or Right [Line Items]	'	'	'	'	'	'	'	'	'	'
Warrants to purchase an aggregate of shares of common stock	'	'	'	'	8,206,520	'	184,367	'	'	'
Warrants issued	'	'	'	'	'	'	'	'	464,520	'
Exercise price of Warrants decreased	'	'	'	'	'	'	'	$3.93	$4.02	'
Warrant exercisable Period	'	'	'	'	'	'	'	'	'6 months	'
Warrant term	'	'	'	'	'5 years	'	'	'	'	'
Estimated fair value of warrant	'	'	'	'	$22,900,000	'	'	'	'	'
Expected volatility	'	'	'	'	105.00%	'	'	'	'	'
Risk-free interest rate	'	'	'	'	2.14%	'	'	'	'	'
Expected life in years	'	'	'	'	'5 years	'	'	'	'	'
Expected dividend yield	'	'	'	'	0.00%	'	'	'	'	'
Sale of stock price per share	'	'	'	'	'	'	'	'	'	$3.50
Warrants outstanding	10,496,467	'	10,496,467	'	'	10,539,767	8,235,076	8,235,076	'	'
Change in fair value of warrants	$5,600,000	($403,000)	$5,682,000	$10,385,000	'	'	'	'	'	'

Assumptions_Used_In_Binomial_V

Assumptions Used In Binomial Valuation Model and Black-Scholes Valuation Model (Detail)	12 Months Ended	6 Months Ended
	Dec. 31, 2009	Jun. 30, 2014	Jun. 30, 2013
		Black Scholes Option Pricing Model	Black Scholes Option Pricing Model
Class of Warrant or Right [Line Items]	'	'	'
Risk-free interest rate	2.14%	0.06%	0.26%
Expected life in years	'5 years	'5 months 9 days	'1 year 5 months 9 days
Expected volatility	105.00%	70.00%	70.00%
Expected dividend yield	0.00%	0.00%	0.00%
Steps Per Year	'	54	12

Warrant_Exercise_Detail

Warrant Exercise (Detail) (USD $)	6 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013
Class of Warrant or Right [Line Items]	'	'
Cash Received	'	101
Equity Warrants	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant exercised	43,300	49,315
Common Stock Issued	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant exercised	21,977	49,315
Cash exercises	'	'
Class of Warrant or Right [Line Items]	'	'
Cash Received	'	101
Cash exercises | Equity Warrants	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant exercised	'	49,315
Cash exercises | Common Stock Issued	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant exercised	'	49,315
Cashless Exercise | Equity Warrants	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant exercised	43,300	'
Cashless Exercise | Common Stock Issued	'	'
Class of Warrant or Right [Line Items]	'	'
Warrant exercised	21,977	'

Common_Stock_Additional_Inform

Common Stock - Additional Information (Detail) (J.P. Morgan Securities Inc., USD $)	0 Months Ended
In Millions, except Share data, unless otherwise specified	Oct. 29, 2013	Oct. 23, 2013
J.P. Morgan Securities Inc.	'	'
Class of Stock [Line Items]	'	'
Stock issued during period	2,145,000	14,300,000
Issuance & sale of common stock in public offering price per share	'	$3.50
Option granted, exercisable period	'	'30 days
Option to purchase common stock	2,145,000	'
Sale of stock price per share	'	$3.29
Net proceeds from issuance of common stock	$53.90	'

StockBased_Compensation_Expens

Stock-Based Compensation Expense on All Employee and Non-Employee Awards (Detail) (USD $)	3 Months Ended		6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'	'	'
Stock-based compensation	$1,212	$132	$2,435	$1,673
Research and Development Expense	'	'	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'	'	'
Stock-based compensation	410	-145	786	392
General and Administrative Expense	'	'	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'	'	'
Stock-based compensation	$802	$277	$1,649	$1,281

StockBased_Compensation_Additi

Stock-Based Compensation - Additional Information (Detail) (USD $)

3 Months Ended

6 Months Ended

0 Months Ended

6 Months Ended

In Millions, except Share data, unless otherwise specified

Jun. 30, 2014

Jun. 30, 2013

Jun. 30, 2014

Jun. 30, 2013

Mar. 31, 2014

Jun. 14, 2013

31-May-13

Jun. 14, 2013

31-May-13

Jun. 14, 2013

31-May-13

Jun. 30, 2014

Jun. 30, 2014

Vested options held by 1 employees

Vested options held by 1 employees

Vested options held by 1 employees

Vested options held by 1 employees

Vested options held by 1 employees

Vested options held by 1 employees

Vested options held by 1 employees

Employee Stock Option

Unvested Restricted Common Stock

Before Extension

Before Extension

After Extension

After Extension

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

'

'

'

'

'

'

'

'

'

'

'

'

'

Stock options, granted

23,800

1,315,500

104,300

1,426,400

'

'

'

'

'

'

'

'

'

Weighted-average grant date fair value

$2.84

$1.77

$3.23

$1.89

'

'

'

'

'

'

'

'

'

Unrecognized compensation costs

$6.20

'

$6.20

'

'

'

'

'

'

'

'

'

'

Expected recognition period

'

'

'

'

'

'

'

'

'

'

'

'1 year 7 months 2 days

'1 year 1 month 2 days

Shares vested

'

'

'

'

71,167

71,167

66,667

'

'

'

'

'

'

Shares vesting period

'

'

'

'

'9 months

'

'

'3 months

'3 months

'12 months

'12 months

'

'

Unrecognized compensation costs related to unvested restricted stock outstanding

'

'

'

'

'

'

'

'

'

'

'

'

$0.70

Fair_Value_of_Stock_Options_As

Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model (Detail)	3 Months Ended
	Jun. 30, 2014	Jun. 30, 2013
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Risk-free interest rate	1.98%	1.65%
Expected life in years	'6 years	'6 years
Expected volatility	94.07%	95.45%
Expected dividend yield	0.00%	0.00%

Stock_Option_Activity_Under_St

Stock Option Activity Under Stock Option Plan (Detail) (USD $)	3 Months Ended		6 Months Ended		12 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013	Dec. 31, 2013
Number of Shares	'	'	'	'	'
Beginning Balance	'	'	6,747,302	'	'
Granted	23,800	1,315,500	104,300	1,426,400	'
Exercised	'	'	-583,038	'	'
Cancelled	'	'	-227,402	'	'
Ending Balance	6,041,162	'	6,041,162	'	6,747,302
Vested and unvested expected to vest at end of period	5,988,240	'	5,988,240	'	'
Options exercisable, at end of period	3,176,594	'	3,176,594	'	3,471,935
Options available for future grant	5,317,831	'	5,317,831	'	'
Weighted Average Exercise Price	'	'	'	'	'
Beginning Balance	'	'	$3.81	'	'
Granted	'	'	$3.54	'	'
Exercised	'	'	$2.26	'	'
Cancelled	'	'	$5.05	'	'
Ending Balance	$3.91	'	$3.91	'	$3.81
Vested and unvested expected to vest at end of period	$4.11	'	$4.11	'	'
Options exercisable, at end of period	$4.11	'	$4.11	'	$4.01
Weighted Average Contractual Term (Years)	'	'	'	'	'
Outstanding, at end of period	'	'	'7 years 2 months 27 days	'	'
Vested and unvested expected to vest at end of period	'	'	'5 years 7 months 10 days	'	'
Options exercisable, at end of period	'	'	'5 years 7 months 10 days	'	'5 years 11 days
Aggregate Intrinsic Value	'	'	'	'	'
Outstanding, at end of period	$4,456	'	$4,456	'	'
Vested and unvested expected to vest at end of period	4,417	'	4,417	'	'
Options exercisable, at end of period	$1,846	'	$1,846	'	$2,654

Summary_of_Unvested_Restricted

Summary of Unvested Restricted Stock (Detail) (Unvested Restricted Common Stock, USD $)	6 Months Ended
	Jun. 30, 2014
Unvested Restricted Common Stock	'
Number of Shares	'
Beginning Balance	352,865
Granted	'
Vested	-48,433
Cancelled	-8,936
Ending Balance	295,496
Weighted Average Grant Date Fair Value	'
Beginning Balance	$4.38
Granted	'
Vested	$4.51
Cancelled	$4.41
Ending Balance	$4.36