Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in this Registration Statement on FormS-3 and related Prospectus of ZIOPHARM Oncology, Inc. of our report dated March 1, 2018, relating to the financial statements and the effectiveness of internal control over financial reporting of ZIOPHARM Oncology, Inc. appearing in the Annual Report on Form10-K of ZIOPHARM Oncology, Inc. for the year ended December 31, 2017.
We also consent to the reference to our firm under the heading “Experts” in such Prospectus.
/s/ RSM US LLP
Boston, Massachusetts
February 7, 2019
