Alaunos Therapeutics (TCRT) 10-Q 8 Aug 19 2019 Q2 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2019	Jul. 24, 2019
Document and Entity Information [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2019
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q2
Entity Registrant Name	ZIOPHARM ONCOLOGY INC
Entity Central Index Key	0001107421
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Trading Symbol	ZIOP
Entity Emerging Growth Company	false
Entity Small Business	true
Entity Common Stock, Shares Outstanding		162,552,963
Entity Interactive Data Current	Yes
Title of 12(b) Security	Common Stock
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Shell Company	false
Entity Address, State or Province	MA

BALANCE SHEETS

BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 43,563	$ 61,729
Receivables	1,460	1,864
Prepaid expenses and other current assets	20,836	20,692
Total current assets	65,859	84,285
Property and equipment, net	877	1,097
Operating lease right of use assets	1,438
Deposits	130	128
Other non-current assets	4,869	9,541
Total assets	73,173	95,051
Current liabilities:
Accounts payable	941	707
Accrued expenses	8,799	8,763
Lease liability - current portion	660
Deferred rent - current portion		13
Total current liabilities	10,400	9,483
Lease liability - noncurrent portion	778
Deferred rent - noncurrent portion		4
Total liabilities	11,178	9,487
Commitments and contingencies (Note 6)
Stockholders' deficit:
Common stock, $0.001 par value; 250,000,000 shares authorized; 162,477,963 and 142,379,770 shares issued and outstanding at June 30, 2019 and December 31, 2018, respectively	162	161
Additional paid-in capital	656,216	651,732
Accumulated deficit	(594,383)	(566,329)
Total stockholders' equity	61,995	85,564
Total liabilities and stockholders' equity	$ 73,173	$ 95,051

BALANCE SHEETS (Parenthetical)

BALANCE SHEETS (Parenthetical) - $ / shares	Jun. 30, 2019	Dec. 31, 2018
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	250,000,000	250,000,000
Common stock, shares issued	162,477,963	142,379,770
Common stock, shares outstanding	162,477,963	142,379,770

STATEMENTS OF OPERATIONS

STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Income Statement [Abstract]
Collaboration revenue				$ 146
Operating expenses:
Research and development	$ 9,998	$ 7,489	$ 19,474	17,672
General and administrative	4,755	4,889	8,900	11,048
Total operating expenses	14,753	12,378	28,374	28,720
Loss from operations	(14,753)	(12,378)	(28,374)	(28,574)
Other income, net	133	164	320	312
Change in fair value of derivative liabilities		183		211
Net loss	(14,620)	(12,031)	(28,054)	(28,051)
Preferred stock dividends		(5,462)		(10,582)
Net loss applicable to common stockholders	$ (14,620)	$ (17,493)	$ (28,054)	$ (38,633)
Basic and diluted net loss per share	$ (0.09)	$ (0.12)	$ (0.17)	$ (0.27)
Weighted average common shares outstanding used to compute basic and diluted net loss per share	160,789,272	141,017,898	160,718,313	140,935,964

STATEMENTS OF CHANGES IN PREFER

STATEMENTS OF CHANGES IN PREFERRED STOCK AND STOCKHOLDERS' Equity (DEFICIT) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid In Capital Common Stock	Accumulated Deficit	Series 1 Preferred Stock - Mezzanine
Balance at Dec. 31, 2017	$ (96,806)	$ 143	$ 615,493	$ (712,442)	$ 143,992
Balance (in shares) at Dec. 31, 2017		142,658,037			119,644
Adjustment for implementation of ASU No. 2014-09, Revenue from Contracts with Customers	(8,131)			(8,131)
Stock-based compensation	5,370		5,370
Exercise of employee stock options	240		240
Exercise of employee stock options (in shares)		104,166
Cancelled restricted common stock (in shares)		(70,867)
Repurchase of restricted common stock	(1,275)	$ (1)	(1,274)
Repurchase of restricted common stock (Shares)		(311,566)
Preferred stock dividends			(10,582)		$ 10,436
Preferred stock dividends	(10,582)
Preferred stock dividends (in shares)					7,358
Net loss	(28,051)			(28,051)
Balance at Jun. 30, 2018	(139,235)	$ 142	609,247	(748,624)	$ 154,428
Balance (in shares) at Jun. 30, 2018		142,379,770			127,002
Balance at Mar. 31, 2018	(123,149)	$ 142	613,302	(736,593)	$ 149,039
Balance (in shares) at Mar. 31, 2018		142,398,936			123,268
Stock-based compensation	1,711		1,711
Exercise of employee stock options	240		240
Exercise of employee stock options (in shares)		104,166
Repurchase of restricted common stock	(544)		(544)
Repurchase of restricted common stock (Shares)		(123,332)
Preferred stock dividends			(5,462)		$ 5,389
Preferred stock dividends	(5,462)
Preferred stock dividends (in shares)					3,734
Net loss	(12,031)			(12,031)
Balance at Jun. 30, 2018	(139,235)	$ 142	609,247	(748,624)	$ 154,428
Balance (in shares) at Jun. 30, 2018		142,379,770			127,002
Balance at Dec. 31, 2018	85,564	$ 161	651,732	(566,329)
Balance (in shares) at Dec. 31, 2018		161,066,136
Stock-based compensation	3,255		3,255
Exercise of employee stock options	$ 600		600
Exercise of employee stock options (in shares)	332,416	258,068
Issuance of restricted common stock	$ 1,000	$ 1	999
Issuance of restricted common stock (in shares)		1,393,536
Cancelled restricted common stock (in shares)		(74,599)
Repurchase of restricted common stock	(370)		(370)
Repurchase of restricted common stock (Shares)		(165,178)
Net loss	(28,054)			(28,054)
Balance at Jun. 30, 2019	61,995	$ 162	656,216	(594,383)
Balance (in shares) at Jun. 30, 2019		162,477,963
Balance at Mar. 31, 2019	74,216	$ 162	653,817	(579,763)
Balance (in shares) at Mar. 31, 2019		162,287,161
Stock-based compensation	1,799		1,799
Exercise of employee stock options	600		600
Exercise of employee stock options (in shares)		258,068
Cancelled restricted common stock (in shares)		(67,266)
Net loss	(14,620)			(14,620)
Balance at Jun. 30, 2019	$ 61,995	$ 162	$ 656,216	$ (594,383)
Balance (in shares) at Jun. 30, 2019		162,477,963

STATEMENTS OF CASH FLOWS

STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Cash flows from operating activities:
Net loss	$ (28,054)	$ (28,051)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	296	255
Stock-based compensation	4,255	5,370
Change in fair value of derivative liabilities		(211)
(Increase) decrease in:
Receivables	404	(645)
Prepaid expenses and other current assets	(144)	7,892
Other noncurrent assets	4,672	(8,447)
Deposits	(2)
Increase (decrease) in:
Accounts payable	234	(3,829)
Accrued expenses	36	(1,245)
Deferred revenue		(146)
Deferred rent	17	(74)
Other liabilities	(33)
Net cash used in operating activities	(18,319)	(29,131)
Cash flows from investing activities:
Purchases of property and equipment	(77)	(376)
Net cash used in investing activities	(77)	(376)
Cash flows from financing activities:
Proceeds from exercise of stock options	600	240
Repurchase of common stock	(370)	(1,275)
Net cash provided by (used in) financing activities	230	(1,035)
Net decrease in cash and cash equivalents, and restricted cash	(18,166)	(30,542)
Cash and cash equivalents, and restricted cash, beginning of period	61,729	71,335
Cash and cash equivalents, and restricted cash, end of period	43,563	40,793
Supplementary disclosure of cash flow information:
Compensation paid in common stock, gross	$ 1,000
Series 1 Preferred Stock
Supplementary disclosure of noncash investing and financing activities:
Payment of dividends in preferred stock		$ 10,582

Business

Business	6 Months Ended
	Jun. 30, 2019
Accounting Policies [Abstract]
Business	1. Business Overview ZIOPHARM Oncology, Inc., which is referred to herein as “ZIOPHARM,” or the “Company,” is a biopharmaceutical company seeking to develop, acquire, and commercialize, on its own or with partners, a diverse portfolio of immuno-oncology therapies. The Company’s operations to date have consisted primarily of conducting research and development and raising capital to fund those efforts. The Company’s fiscal year ends on December 31. The Company has operated at a loss since its inception in 2003 and has no recurring revenues from operations. The Company anticipates that losses will continue for the foreseeable future. As of June 30, 2019, the Company had approximately $ 43.6 the Company anticipates cash resources will be sufficient to fund operations into the first half of 2021. The Company’s ability to continue operations after its current cash resources are exhausted depends on its ability to obtain additional financing or to achieve profitable operations, as to which no assurances can be given. Cash requirements may vary materially from those now planned because of changes in the Company’s focus and direction of its research and development programs, competitive and technical advances, patent developments, regulatory changes or other developments. If adequate additional funds are not available when required, or if the Company is unsuccessful in entering into partnership agreements for further development of its product candidates, management may need to curtail its development efforts and planned operations to conserve cash. Basis of Presentation The accompanying unaudited interim financial statements have been prepared in accordance with the instructions to Form 10-Q It is management’s opinion that the accompanying unaudited interim financial statements reflect all adjustments (which are normal and recurring) that are necessary for a fair statement of the results for the interim periods. The unaudited interim financial statements should be read in conjunction with the audited financial statements and the notes thereto for the year ended December 31, 2018, included in the Company’s Annual Report on Form 10-K 10-K. The year-end The results disclosed in the statements of operations for the three and six months ended June 30, 2019 are not necessarily indicative of the results to be expected for the full fiscal year. Use of Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Although the Company regularly assesses these estimates, actual results could differ from those estimates. Changes in estimates are recorded in the period in which they become known. The Company’s most significant estimates and judgments used in the preparation of its financial statements are: • Clinical trial expenses; • Collaboration agreements and revenue recognition; • Fair value measurements of stock-based compensation and Series 1 preferred stock; and • Income taxes Subsequent Events The Company evaluated all events and transactions that occurred after the balance sheet date through the date of this filing. Except as disclosed below, the Company did not have any material subsequent events that impacted its financial statements or disclosures. On December 18, 2018, the Company and TriArm Therapeutics, Ltd., or TriArm, announced their plans to establish a joint venture, Eden BioCell, Ltd., to lead clinical development and commercialization of Sleeping Beauty For the territory of China, Taiwan and Korea, the Company has licensed the rights to Eden BioCell, Ltd., or Eden BioCell, for third-generation Sleeping Beauty Sleeping Beauty On July 29, 2019, the Company announced that it entered into an agreement with existing investors for the exercise of previously issued warrants to purchase common stock in a private placement. Pursuant to the terms of the agreement, investors have agreed to exercise warrants for an aggregate of 15,015,152 shares of common stock, at an exercise price of $3.01 per share. The warrants being exercised were originally issued by the Company in a private placement that closed in November 2018. The Company will issue new warrants to purchase up to 15,015,152 additional shares of common stock. The warrants will become exercisable six months following the date of issuance, will expire on the fifth anniversary of the initial exercise date, and have an exercise price of $7.00. Gross proceeds from the offering, before deducting placement agent and other offering expenses is approximately $45.0 million.

Summary of Significant Accounti

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2019
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies The Company’s significant accounting policies were identified in the Company’s Form 10-K. 10-K Leases In February 2016, the FASB issued ASU 2016-02, right-of-use The standard permits two transition methods, (1) to apply the new lease requirements at the beginning of the earliest period presented, or (2) to apply the new lease requirements at the effective date. The Company adopted Topic 842 as of January 1, 2019 using the effective date method, in which it did not restate prior periods. Upon adoption, the Company elected the package of practical expedients permitted under the transition guidance within Topic 842 which, among other things, allowed it to carry forward the historical lease classification. The adoption of Topic 842 on January 1, 2019 resulted in recognition of approximately $1.6 million of right-of-use New Accounting Pronouncements In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement 2018-03. In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting 2018-07.

Fair Value Measurements

Fair Value Measurements	6 Months Ended
	Jun. 30, 2019
Fair Value Disclosures [Abstract]
Fair Value Measurements	3. Fair Value Measurements The Company accounts for its financial assets and liabilities using fair value measurements. The authoritative accounting guidance defines fair value, establishes a framework for measuring fair value under generally accepted accounting principles and enhances disclosures about fair value measurements. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The fair value hierarchy is based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value as follows: • Level 1—Quoted prices in active markets for identical assets or liabilities. • Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. Assets and liabilities measured at fair value on a recurring basis as of June 30, 2019 and December 31, 2018 were as follows: ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 24,706 $ 24,706 $ — $ — ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 24,437 $ 24,437 $ — $ — The cash equivalents represent deposits in a short-term United States treasury money market mutual fund quoted in an active market and classified as a Level 1 asset.

Net Loss per Share

Net Loss per Share	6 Months Ended
	Jun. 30, 2019
Earnings Per Share [Abstract]
Net Loss per Share	4. Net Loss per Share Basic net loss per share is computed by dividing net loss by the weighted average number of shares of common stock outstanding for the period. The Company’s potentially dilutive shares, which include outstanding common stock options, unvested restricted stock and preferred stock, have not been included in the computation of diluted net loss per share for any of the periods presented as the result would be anti-dilutive. Such potentially dilutive shares of common stock at June 30, 2019 and 2018 consisted of the following: June 30, 2019 2018 Stock options 5,077,591 4,303,802 Inducement stock options 500,000 — Unvested restricted stock 1,554,579 1,198,868 Warrants 18,939,394 — Preferred stock — 41,754,054 26,071,564 47,256,724 On October 5, 2018, the Company and Precigen, Inc., or Precigen, a wholly owned subsidiary of Intrexon Corporation, or Intrexon, entered into an exclusive license agreement, or the License Agreement, to replace all existing agreements between the companies that provides the Company with certain exclusive and non-exclusive rights to technology controlled by Precigen. In consideration of the Company entering into the License Agreement, Intrexon agreed to forfeit and return to the Company all shares of the Company’s Series 1 Preferred Stock held by or payable to Intrexon as of the date of the License Agreement (Note 8).

Revenue Recognition

Revenue Recognition	6 Months Ended
	Jun. 30, 2019
Revenue from Contract with Customer [Abstract]
Revenue Recognition	5. Revenue Recognition The Company adopted Accounting Standards Codification, or ASC Topic 606, Revenue from Contracts with Customers, not The Company primarily generates revenue through collaboration arrangements with strategic partners for the development and commercialization of product candidates. Commencing January 1, 2018, the Company recognized revenue in accordance with ASC 606 which replaced ASC 605, Multiple Element Arrangements The Company recognizes collaboration revenue under certain of the Company’s license or collaboration agreements that are within the scope of ASC 606. The Company’s contracts with customers typically include promises related to licenses to intellectual property, research and development services and options to purchase additional goods and/or services. If the license to the Company’s intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, the Company recognizes revenue from non-refundable, up-front fees allocated to the license when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For licenses that are bundled with other promises, the Company utilizes judgement to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front fees. Contracts that include an option to acquire additional goods and/or services are evaluated to determine if such option provides a material right to the customer that it would not have received without entering into the contract. If so, the option is accounted for as a separate performance obligation. If not, the option is considered a marketing offer which would be accounted for as a separate contract upon the customer’s election. The terms of the Company’s arrangements with customers typically include the payment of one or more of the following: (i) non-refundable, up-front catch-up The Company allocates the transaction price to each performance obligation identified in the contract on a relative standalone selling price basis. However, certain components of variable consideration are allocated specifically to one or more particular performance obligations in a contact to the extent both of the following criteria are met: (i) the terms of the payment relate specifically to the efforts to satisfy the performance obligation or transfer the distinct good or service and (ii) allocating the variable amount of consideration entirely to the performance obligation or the distinct good or service is consistent with the allocation objective of the standard whereby the amount allocated depicts the amount of consideration to which the entity expects to be entitled in exchange for transferring the promised goods or services. The Company develops assumptions that require judgment to determine the standalone selling price for each performance obligation identified in each contract. The key assumptions utilized in determining the standalone selling price for each performance obligation may include forecasted revenues, development timelines, estimated research and development costs, discount rates, likelihood of exercise and probabilities of technical and regulatory success. Revenue is recognized based on the amount of the transaction price that is allocated to each respective performance obligation when or as the performance obligation is satisfied by transferring a promised good and/or service to the customer. For performance obligations that are satisfied over time, the Company recognizes revenue by measuring the progress toward complete satisfaction of the performance obligation using a single method of measuring progress which depicts the performance in transferring control of the associated goods and/or services to the customer. The Company uses input methods to measure the progress toward the complete satisfaction of performance obligations satisfied over time. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. Any such adjustments are recorded on a cumulative catch-up As it relates to the Ares Trading Agreement (Note 6), the Company recognized the upfront payment associated with its one open contract as a contract liability upon receipt of payment as it requires deferral of revenue recognition to a future period until the Company performs its obligations under the arrangement. The Company determined that there were three performance obligations; the first performance obligation consists of the license and research development services and the other two performance obligations are material rights as it relates to potential future targets that have not yet been identified. As described above, the transaction price of $57.5 million was allocated to the performance obligations based on their relative standalone selling prices (Note 6). The Company did not believe that any variable consideration should be included in the transaction price at the date of adoption of ASC 606 on January 1, 2018. Such assessment considered the application of the constraint to ensure that estimates of variable consideration would be included in the transaction price only to the extent the Company had a high degree of confidence that revenue would not be reversed in a subsequent reporting period. The Company re-evaluated On October 5, 2018, the Company entered into the license agreement with Precigen (Note 8). As between the Company and Precigen, the terms of the License Agreement replace the terms of: (a) the Channel Agreement previously entered into with Intrexon Corporation (the “Channel Agreement”), including all amendments to the Channel Agreement; (b) certain rights and obligations pursuant to the Ares Trading Agreement; (c) the MD Anderson License (Note 6); and (d) that certain Research and Development Agreement between the Company, Intrexon and The University of Texas MD Anderson Cancer Center, or MD Anderson, with an effective date of August 17, 2015 or the Research and Development Agreement, and any amendments or statements of work thereto. In partial consideration of the Company entering into the License Agreement, Precigen is required to use diligent good faith efforts to transfer the Company’s rights and obligations under the Ares Trading Agreement to Intrexon (or its affiliate). As a result, the Company has very limited remaining obligations under the Ares Trading Agreement, and following the Company’s entry into the License Agreement, will not be recognizing any additional revenue under the Ares Trading Agreement.

Commitments and Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2019
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	6. Commitments and Contingencies License Agreements Exclusive License Agreement with Precigen, Inc. On October 5, 2018, the Company entered into the License Agreement, with Precigen. As between the Company and Precigen, the terms of the License Agreement replace and supersede the terms of: (a) that certain Exclusive Channel Partner Agreement by and between the Company and Intrexon, dated January 6, 2011, as amended by the First Amendment to Exclusive Channel Partner Agreement effective September 13, 2011, the Second Amendment to the Exclusive Channel Partner Agreement effective March 27, 2015, and the Third Amendment to Exclusive Channel Partner Agreement effective June 29, 2016, which was subsequently assigned by Intrexon to Precigen; (b) certain rights and obligations pursuant to that certain License and Collaboration Agreement effective March 27, 2015 between the Company, Intrexon and ARES TRADING S.A., or Ares Trading, a subsidiary of Merck KGaA, or Merck, as assigned by Intrexon to Precigen, or the Ares Trading Agreement; (c) that certain License Agreement between the Company, Intrexon, and MD Anderson, with an effective date of January 13, 2015, or the MD Anderson License, which was subsequently assigned by Intrexon and assumed by Precigen effective as of January 1, 2018; and (d) that certain Research and Development Agreement between the Company, Intrexon and MD Anderson with an effective date of August 17, 2015, or the Research and Development Agreement, and any amendments or statements of work thereto. Pursuant to the terms of the License Agreement, Precigen has granted the Company an exclusive, worldwide, royalty-bearing, sub-licensable ® IL-12 sub-licensable Sleeping Beauty The Company will be solely responsible for all aspects of the research, development and commercialization of the exclusively licensed products for the treatment of cancer. The Company is required to use commercially reasonable efforts to develop and commercialize IL-12 two-year Precigen has also granted the Company an exclusive, worldwide, royalty-bearing, sub-licensable IL-12 IL-12 In consideration of the licenses and other rights granted by Precigen, the Company will pay Precigen an annual license fee of $0.1 million and has agreed to reimburse Precigen for certain historical costs of the licensed programs up to $1.0 million, payable quarterly. The Company will make milestone payments totaling up to an additional $52.5 million for each exclusively licensed program upon the initiation of later stage clinical trials and upon the approval of exclusively licensed products in various jurisdictions. In addition, the Company will pay Precigen tiered royalties ranging from low-single IL-12 low-single mid-single The Company is responsible for all development costs associated with each of the licensed products, other than Gorilla IL-12 IL-12 Precigen will pay the Company royalties ranging from low-single mid-single In consideration of entering into the License Agreement, Intrexon has forfeited and returned to the Company all shares of Series 1 preferred stock held by or payable to Intrexon as of the date of the License Agreement (Note 8). License Agreement—The University of Texas MD Anderson Cancer Center On January 13, 2015, the Company, together with Intrexon, entered into the MD Anderson License with MD Anderson (which Intrexon subsequently assigned to Precigen). Pursuant to the MD Anderson License, the Company, together with Precigen, holds an exclusive, worldwide license to certain technologies owned and licensed by MD Anderson including technologies relating to novel CAR T-cell non-viral On August 17, 2015, the Company, Precigen and MD Anderson entered into the Research and Development Agreement, to formalize the scope and process for the transfer by MD Anderson, pursuant to the terms of the MD Anderson License, of certain existing research programs and related technology rights, as well as the terms and conditions for future collaborative research and development of new and ongoing research programs. Pursuant to the Research and Development Agreement, the Company, Precigen and MD Anderson formed a joint steering committee to oversee and manage the new and ongoing research programs. Under the License Agreement with Precigen, the Company and Precigen agreed that Precigen would no longer participate on the joint steering committee after the date of the License Agreement. As provided under the MD Anderson License, the Company provided funding for research and development activities in support of the research programs under the Research and Development Agreement for a period of three years and in an amount of no less than $15.0 million and no greater than $20.0 million per year. On November 14, 2017, the Company entered into an amendment to the Research and Development Agreement extending its term until April 15, 2021. During the six months ended June 30, 2019 and 2018, the Company expensed approximately $3.0 million and $2.2 million, respectively, for its research programs being conducted in Houston. The net balance of cash resources on hand at MD Anderson available to offset expenses and future costs is $24.2 million, of which $19.4 million is included in other current assets and the remaining $4.8 million is included in non-current non-current The term of the MD Anderson License expires on the last to occur of (a) the expiration of all patents licensed thereunder, or (b) the twentieth anniversary of the date of the MD Anderson License; provided, however, that following the expiration of the term of the MD Anderson License, the Company, together with Precigen, shall then have a fully-paid up, royalty free, perpetual, irrevocable and sublicensable license to use the licensed intellectual property thereunder. After ten years from the date of the MD Anderson License and subject to a 90-day non-exclusive case-by-case 180-day License Agreement with the National Cancer Institute On May 28, 2019, the Company entered into a patent license agreement, or the Patent License, with the National Cancer Institute, or the NCI. Pursuant to the Patent License, the Company holds an exclusive, worldwide license to certain intellectual property to develop and commercialize patient-derived (autologous), peripheral blood T-cell therapy products engineered by transposon-mediated gene transfer to express TCRs reactive to mutated KRAS, p53 and EGFR. In addition, pursuant to the Patent License, the Company holds an exclusive, worldwide license to certain intellectual property for manufacturing technologies to develop and commercialize autologous, peripheral blood T-cell therapy products engineered by non-viral gene transfer to express TCRs, as well as a non-exclusive, worldwide license to certain additional manufacturing technologies. Pursuant to the terms of the Patent License, the Company is required to pay the NCI a cash payment in the aggregate amount of $1.5 million, which is included in current liabilities at June 30, 2019. The Company also agreed to reimburse the NCI for past patent expenses in the aggregate amount of approximately $46 thousand. At June 30, 2019, the Company recorded both the $1.5 million payment due upon the execution of the Patent License and the $46 thousand in patent expenses for accrued current liabilities on the Company’s balance sheet. The terms of the Patent License also require the Company to pay the NCI minimum annual royalties in the amount of $0.3 million, which amount will be reduced to $0.1 million once the aggregate minimum annual royalties paid by the Company equals $1.5 million. The first minimum annual royalty payment is payable on the date that is eighteen months following the date of the Patent License. The Company is also required to make performance-based payments upon successful completion of clinical and regulatory benchmarks relating to the licensed products. The aggregate potential benchmark payments are $4.3 million, of which aggregate payments of $3.0 million are due only after marketing approval in the United States or in Europe, Japan, Australia, China or India. The first benchmark payment of $0.1 million will be due upon the initiation of the Company’s first sponsored phase 1 clinical trial of a licensed product or licensed process in the field of use licensed under the Patent License. In addition, the Company is required to pay the NCI one-time mid-single The Patent License will expire upon expiration of the last patent contained in the licensed patent rights, unless terminated earlier. The NCI may terminate or modify the Patent License in the event of a material breach, including if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event. The Company may terminate the Patent License, or any portion thereof, in the Company’s sole discretion at any time upon 60 days’ written notice to the NCI. In addition, the NCI has the right to: (i) require the Company to sublicense the rights to the product candidates covered by the Patent License upon certain conditions, including if the Company is not reasonably satisfying required health and safety needs if the Company is not satisfying requirements for public use as specified by federal regulations. Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute On January 10, 2017, the Company announced the signing of a Cooperative Research and Development Agreement, or CRADA, with the NCI for the development of adoptive cell transfer, or ACT,-based immunotherapies genetically modified using the Sleeping Beauty non-viral Sleeping Beauty In February 2019, the Company extended the CRADA with the NCI for two years, committing an additional $5.0 million to this program through January 2022. The remaining obligation, as of June 30, 2019, to the NCI under the CRADA is $6.3 million over the next two years, payable in $0.6 million payments on a quarterly basis. The Company made payments of $ 0.6 Exclusive Channel Partner Agreement with Precigen for the Cancer Programs From 2011 to 2018, the Company was party to various arrangements with Intrexon (now Precigen) in which the Company used Precigen’s technology to research and develop cancer treatments in return for various future profit sharing and royalty arrangements. These agreements were modified or terminated by the License Agreement described in Note 8. Ares Trading License and Collaboration Agreement On March 27, 2015, the Company, together with Intrexon (now Precigen), signed the Ares Trading Agreement, with Ares Trading, through which the parties established a collaboration for the research and development and commercialization of certain products for the prophylactic, therapeutic, palliative or diagnostic use for cancer in humans. Precigen was entitled to receive $5.0 million, from Ares Trading, payable in equal quarterly installments over two years for each identified product candidate, which will be used to fund discovery work. The Company was responsible for costs exceeding the quarterly installments and all other costs of the preclinical research and development. For the three and six months ended June 30, 2018, the Company expensed $36 thousand under the Ares Trading Agreement. The Company did not incur any costs under the agreement for the six months ended June 30, 2019 as there are no continuing obligations to reimburse Precigen for expenses under the Ares Trading Agreement Ares Trading paid a non-refundable Under the License Agreement, Precigen agreed to perform all future obligations of the Company under the Ares Trading Agreement other than certain payment obligations. Accordingly, the Company recognized the remaining deferred revenue as part of the settlement of a related party relationship as described in Note 8. Patent and Technology License Agreement—The University of Texas MD Anderson Cancer Center and the Texas A&M University System On August 24, 2004, the Company entered into a patent and technology license agreement with MD Anderson and the Texas A&M University System, which the Company refers to, collectively, as the Licensors. Under this agreement, the Company was granted an exclusive, worldwide license to rights (including rights to U.S. and foreign patent and patent applications and related improvements and know-how) two Under the terms of the agreement, the Company may be required to make additional payments to the Licensors upon achievement of certain other milestones in varying amounts which, on a cumulative basis could total up to an additional $4.5 million. In addition, the Licensors are entitled to receive single digit percentage royalty payments on sales from a licensed product and will also be entitled to receive a portion of any fees that the Company may receive from a possible sublicense under certain circumstances. Collaboration Agreement with Solasia Pharma K.K. On March 7, 2011, the Company entered into a License and Collaboration Agreement with Solasia which was amended on July 31, 2014 to include an exclusive worldwide license. Pursuant to the License and Collaboration Agreement, the Company granted Solasia an exclusive license to develop and commercialize darinaparsin in both intravenous and oral forms and related organic arsenic molecules, in all indications for human use As consideration for the license, the Company is eligible to receive from Solasia development- and sales-based milestones, a royalty on net sales of darinaparsin, once commercialized, and a percentage of any sublicense revenues generated by Solasia. Solasia will be responsible for all costs related to the development, manufacturing and commercialization of darinaparsin. The Company’s Licensors, as defined in the agreement, will receive a portion of all milestone and royalty payments made by Solasia to the Company in accordance with the terms of the license agreement with the Licensors.

Related Party Transactions

Related Party Transactions	6 Months Ended
	Jun. 30, 2019
Related Party Transactions [Abstract]
Related Party Transactions	7. Related Party Transactions Collaborations with Intrexon/ Precigen During the three months ended June 30, 2018, the Company issued an aggregate of 3,734 shares of Series 1 preferred stock to Intrexon, the holder of all of the outstanding shares of the Company’s Series 1 preferred stock, as monthly dividend payments. At June 30, 2018, the Company recorded such shares of Series 1 preferred stock at a fair value of $5.4 million which is a component of temporary equity. During the six months ended June 30, 2018, the Company recorded a gain on the change of the derivative liabilities in the amount of $0.2 million. During the six months ended June 30, 2019 and 2018, the Company expensed $1.5 million and $4.7 million, respectively, for services performed by Precigen. As of June 30, 2019 and 2018, the Company recorded $1.1 million and $1.9 million, respectively, in current liabilities on its balance sheet for amounts due to Precigen. On October 5, 2018, the Company entered into the License Agreement, the terms of which replaced the terms of the Channel Agreement. Collaboration with Precigen and MD Anderson On January 13, 2015, the Company, together with Intrexon, entered into the MD Anderson License with MD Anderson (which Intrexon subsequently assigned to Precigen). Pursuant to the MD Anderson License, the Company, together with Precigen, hold an exclusive, worldwide license to certain technologies owned and licensed by MD Anderson including technologies relating to novel CAR T cell non-viral The Company has determined that the rights acquired in the MD Anderson License represent in-process non-current

Settlement of a Related Party R

Settlement of a Related Party Relationship	6 Months Ended
	Jun. 30, 2019
Related Party Transactions [Abstract]
Settlement of relatedparty relationship	8. Settlement of a Related Party Relationship Exclusive License Agreement with Precigen On October 5, 2018, the Company entered into the license agreement with Precigen. As between the Company and Precigen, the terms of the License Agreement replace the terms of: (a) the Channel Agreement, including all amendments to the Channel Agreement; (b) certain rights and obligations pursuant to the Ares Trading Agreement; (c) the MD Anderson License; and (d) the Research and Development Agreement, and any amendments or statements of work thereto. Pursuant to the terms of the License Agreement, Precigen has granted the Company an exclusive, worldwide, royalty-bearing, sub-licensable ® IL-12 sub-licensable Sleeping Beauty The Company is solely responsible for all aspects of the research, development and commercialization of the exclusively licensed products for the treatment of cancer. The Company is required to use commercially reasonable efforts to develop and commercialize IL-12 two-year sub-licensable IL-12 Ziopharm agreed to reimburse Precigen for certain historical costs of the licensed programs up to $1.0 million, payable quarterly. The Company determined that the fair value of this program was $1.0 million, and this was expensed in accordance with ASC 730, Research and Development The agreement also calls for an annual license fee of $0.1 million as long as the agreement is effective. The Company will also make milestone payments totaling up to an additional $52.5 million for each exclusively licensed program upon the initiation of later stage clinical trials and upon the approval of exclusively licensed products in various jurisdictions. In addition, the Company will pay Precigen tiered royalties ranging from low-single IL-12 low-single mid-single The Company is responsible for all development costs associated with each of the licensed products, other than Gorilla IL-12 IL-12 Precigen will pay the Company royalties ranging from low-single mid-single In consideration of the Company entering into the License Agreement, Intrexon forfeited and returned to the Company all shares of the Company’s Series 1 preferred stock held by or payable to Intrexon as of the date of the License Agreement. In addition, Precigen is required to transfer all of Ziopharm’s rights and obligations under the Ares Trading Agreement to Intrexon (or its affiliate). See Note 6 the Company’s remaining obligations under the Ares Trading Agreement. The Company determined that this transaction represented a capital transaction between related parties. The Company calculated the fair value of the preferred stock and the derivative liability on the date of the transaction, noting a total fair value of $163.3 million. The relinquishment of the Company’s obligation under the Ares Trading Agreement was also considered part of the overall capital transaction. The Company recognized an additional credit to accumulated deficit of $49.5 million as a result of the relief of the obligation under the Ares Trading Agreement (Note 6). The total amount of the settlement was $212.8 million. The Company incurred approximately $ 7.4 5.4 2.0 The Company recognized a net credit to accumulated deficit of $ 207.3 5.4

Leases

Leases	6 Months Ended
	Jun. 30, 2019
Leases, Operating [Abstract]
Leases	9. Leases The Company adopted Topic 842 on January 1, 2019 using the effective date method, in which it did not restate prior periods. Upon adoption, the Company elected the package of practical expedients permitted under the transition guidance within Topic 842 which, among other things, allowed it to carry forward the historical lease classification. The Company does not allocate consideration in its leases to lease and non-lease The Company uses its estimated incremental borrowing rate, which is derived from information available at the lease commencement date, in determining the present value of lease payments. The Company’s incremental borrowing rate represents the rate of interest that it would have to pay to borrow over a similar term an amount equal to the lease payments in a similar economic environment. The Company considers publicly available data for instruments with similar terms and characteristics when determining its incremental borrowing rates. The adoption of Topic 842 resulted in recognition of approximately $1.6 million of right-of-use right-of-use In June 2012, the Company entered into a master lease for the Company’s corporate headquarters in Boston office, which was originally set to expire in August 2016, but renewed through August 31, 2021. As of June 30, 2019, and December 31, 2018, a total security deposit of $0.1 million is included in deposits on the balance sheet. On January 30, 2018, the Company entered into a lease agreement for office space in Houston at MD Anderson. Under the terms of the Houston lease agreement, the Company leases approximately two hundred and ten square feet and are required to make rental payments at an average monthly rate of approximately $1 thousand through April 2021. All future rent expense incurred in Houston, will be deducted from the Company’s prepayments at MD Anderson. On March 12, 2019, the Company entered into a lease agreement for office space in Houston. Under the terms of the Houston lease agreement, the Company leases approximately one thousand and thirty-eight square feet and is required to make rental payments at an average monthly rate of approximately $2 thousand through April 2021. As of June 30, 2019, a total security deposit of $2 thousand is included in deposits on the balance sheet. The components of lease expense were as follows: (in thousands) Three Months Ended Six Months Ended Operating lease cost $ 182 $ 360 Total lease cost $ 182 $ 360 Weighted-average remaining lease term (years) 2.40 2.40 Weighted-average discount rate 8.00 % 8.00 % Cash paid for amounts included in the measurement of the lease liabilities were $0.4 million for the six months ended June 30, 2019. As of June 30, 2019, the maturities of the Company’s operating lease liabilities were as follows (in thousands): Maturity of Lease Liabilities Operating Leases 2019 (excluding the six months ended June 30, 2019) 373 2020 755 2021 491 Total lease payments $ 1,619 Less: Imputed Interest and Adjustments 181 Present value of lease payments $ 1,438 Disclosures related to periods prior to adoption of the New Lease Standard Prior to the adoption of ASC 842, the Company recorded rent expense on a straight-line basis over the term of the lease under ASC 840. Total rent expense for the three and six months ended June 30, 2018 was approximately $0.2 million and $ 0.4 For comparative purposes, the Company’s aggregate future minimum non-cancellable 2019 723 2020 736 2021 488 Future minimum lease payments, net $ 1,947

Stock-Based Compensation

Stock-Based Compensation	6 Months Ended
	Jun. 30, 2019
Text Block [Abstract]
Stock-Based Compensation	10. Stock-Based Compensation The Company recognized stock-based compensation expense on all employee and non-employee For the three months ended June 30, For the six months ended June 30, (in thousands) 2019 2018 2019 2018 Research and development $ 297 $ 609 $ 729 $ 1,212 General and administrative 1,502 1,102 2,526 4,158 Stock-based compensation expense $ 1,799 $ 1,711 $ 3,255 $ 5,370 The Company granted an aggregate of 199,422 and 1,695,755 stock options during the three and six months ended June 30, 2019 with a weighted-average grant date fair value of $3.13 and $1.80 per share, respectively. The Company granted an aggregate of 198,000 and 205,500 stock options during the three and six months ended June 30, 2018 with a weighted average grant date fair value of $3.06 and $3.06 per share, respectively. On January 6, 2019, the Company paid an accrued annual performance bonus by issuing 446,428 shares of common stock. On June 13, 2019 the Company extended the contractual life of 52,500 fully vested stock options held by a director of the Company. Additionally, on June 13, 2019, the Company accelerated the vesting and extended the contractual life of 126,700 stock options held by a director. These extensions and acceleration of vesting resulted in additional stock compensation expense of $0.4 million in the three and six months ended June 30, 2019. On February 15, 2018, the Company extended the contractual life of 751,667 fully vested stock options held by an officer of the Company by an additional nine months. Additionally, on March 12, 2018, the Company extended the contractual life of 117,500 fully vested stock options held by a director. These extensions resulted in additional stock compensation expense of $0 and $0.5 million in the three and six months ended June 30, 2018, respectively. The Company recognizes forfeitures as they occur. For the three months ended June 30, 2019 and 2018, the fair value of stock options was estimated on the date of grant using a Black-Scholes option valuation model with the following assumptions: For the three months ended June 30, 2019 2018 Risk-free interest rate 1.89 - 2.42% 2.66 - 2.91% Expected life in years 5.75 - 6.25 6 Expected volatility 72.68 - 78.85% 81.48 - 81.66% Expected dividend yield 0 0 Stock option activity under the Company’s stock option plan for the six months ended June 30, 2019 is as follows: (in thousands, except share and per share data) Number of Weighted- Weighted- Aggregate Outstanding, December 31, 2018 5,277,085 $ 4.24 Granted 1,695,755 2.54 Exercised (332,416 ) 2.95 Cancelled (1,562,833 ) 4.14 Outstanding, June 30, 2019 5,077,591 $ 3.78 7.91 $ 12,463 Options exercisable, June 30, 2019 2,378,158 $ 4.90 5.93 $ 4,220 Options exercisable, December 31, 2018 3,099,935 $ 5.15 4.93 $ 88 Options available for future grant 4,069,982 At June 30, 2019, total unrecognized compensation costs related to unvested stock options outstanding amounted to $5.6 million. The cost is expected to be recognized over a weighted-average period of 1.58 years. A summary of the status of unvested restricted stock for the six months ended June 30, 2019 is as follows: Number of Shares Weighted-Average Non-vested, 682,070 $ 3.47 Granted 1,393,536 2.24 Vested (446,428 ) 2.24 Cancelled (74,599 ) 3.41 Non-vested, 1,554,579 $ 2.90 At June 30, 2019, total unrecognized compensation costs related to unvested restricted stock outstanding amounted to $3.3 million. The cost is expected to be recognized over a weighted-average period of 1.54 years.

Preferred Stock

Preferred Stock	6 Months Ended
	Jun. 30, 2019
Equity [Abstract]
Preferred Stock	11. Preferred Stock The Company’s Board of Directors is authorized to designate any series of Preferred Stock, to fix and determine the variations in relative rights, preferences, privileges and restrictions as between and among such series. On June 29, 2016, the Company entered into the 2016 ECP Amendment and Amendment to Exclusive Channel Collaboration Agreement, or the 2016 GvHD Amendment, with Intrexon (now Precigen) (Note 6). In consideration for the execution and delivery of the 2016 ECP Amendment and the 2016 GvHD Amendment, the Company issued to Intrexon 100,000 shares of its newly designated Series 1 preferred stock. Each share of the Company’s Series 1 preferred stock had a stated value of $1,200, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other recapitalization. The Series 1 preferred stock had certain rights, preferences, privileges and obligations, including dividend rights, conversion rights, consent rights with respect to certain Company actions, and rights to preferential payments in the event of any voluntary or involuntary liquidation, dissolution or winding up of the Company or a change of control or sale, lease, transfer or exclusive license of all or substantially all of the Company’s assets prior to the conversion of the Series 1 preferred stock. On October 5, 2018, the Company and Precigen entered into the License Agreement to replace all existing agreements between the companies, which provides the Company with certain exclusive and non-exclusive

Derivative Financial Instrument

Derivative Financial Instruments	6 Months Ended
	Jun. 30, 2019
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Derivative Financial Instruments	12. Derivative Financial Instruments The Company determined that certain embedded features related to the Series 1 preferred stock were derivative financial instruments. The company values the embedded derivative financial instruments related to the Series 1 preferred stock as Level 3 financial liabilities (Note 3). On October 5, 2018, the Company entered into the License Agreement with Precigen. In partial consideration for the termination of the former agreements, the agreed that Intrexon would forfeit all outstanding shares of the Series 1 preferred stock held by Intrexon, including any accrued dividends and related financial instruments. Thus, upon closing of the transaction were no longer outstanding (Note 8).

Warrants

Warrants	6 Months Ended
	Jun. 30, 2019
Warrants Disclosure [Abstract]
Warrant	13. Warrants In connection with the Company’s November 2018 private placement which provided net proceeds of approximately $47.1 million, the Company issued warrants to purchase an aggregate of 18,939,394 shares of common stock which became exercisable six months after the closing of the private placement. The warrants have an exercise price of $3.01 per share and have a five-year term. The relative fair value of the warrants was estimated at $18.4 million using a Black-Scholes model with the following assumptions: expected volatility of 71%, risk free interest rate of 2.99%, expected life of five no The Company assessed whether the warrants require accounting as derivatives. The Company determined that the warrants were (1) indexed to the Company’s own stock and (2) classified in stockholders’ equity in accordance with Financial Accounting Standards Board (FASB”) Accounting Standards Codification (“ASC”) Topic 815, Derivatives and Hedging On July 29, 2019, the Company announced that it entered into an agreement with existing investors for the exercise of warrants issued during the November 2018 private placement to purchase common stock in a new private placement (Note 2).

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2019
Accounting Policies [Abstract]
Leases	Leases In February 2016, the FASB issued ASU 2016-02, right-of-use The standard permits two transition methods, (1) to apply the new lease requirements at the beginning of the earliest period presented, or (2) to apply the new lease requirements at the effective date. The Company adopted Topic 842 as of January 1, 2019 using the effective date method, in which it did not restate prior periods. Upon adoption, the Company elected the package of practical expedients permitted under the transition guidance within Topic 842 which, among other things, allowed it to carry forward the historical lease classification. The adoption of Topic 842 on January 1, 2019 resulted in recognition of approximately $1.6 million of right-of-use
New Accounting Pronouncements	New Accounting Pronouncements In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement 2018-03. In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting 2018-07.

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	6 Months Ended
	Jun. 30, 2019
Fair Value Disclosures [Abstract]
Assets and Liabilities Measured at Fair Value on Recurring Basis	Assets and liabilities measured at fair value on a recurring basis as of June 30, 2019 and December 31, 2018 were as follows: ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 24,706 $ 24,706 $ — $ — ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 24,437 $ 24,437 $ — $ —

Net Loss per Share (Tables)

Net Loss per Share (Tables)	6 Months Ended
	Jun. 30, 2019
Earnings Per Share [Abstract]
Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share	Such potentially dilutive shares of common stock at June 30, 2019 and 2018 consisted of the following: June 30, 2019 2018 Stock options 5,077,591 4,303,802 Inducement stock options 500,000 — Unvested restricted stock 1,554,579 1,198,868 Warrants 18,939,394 — Preferred stock — 41,754,054 26,071,564 47,256,724

Leases (Tables)

Leases (Tables)	6 Months Ended
	Jun. 30, 2019
Leases, Operating [Abstract]
Components of Lease Expense	The components of lease expense were as follows: (in thousands) Three Months Ended Six Months Ended Operating lease cost $ 182 $ 360 Total lease cost $ 182 $ 360 Weighted-average remaining lease term (years) 2.40 2.40 Weighted-average discount rate 8.00 % 8.00 %
Lessee, Operating Lease, Liability, Maturity	As of June 30, 2019, the maturities of the Company’s operating lease liabilities were as follows (in thousands): Maturity of Lease Liabilities Operating Leases 2019 (excluding the six months ended June 30, 2019) 373 2020 755 2021 491 Total lease payments $ 1,619 Less: Imputed Interest and Adjustments 181 Present value of lease payments $ 1,438
Future Net Minimum Lease Payments under Operating Leases	For comparative purposes, the Company’s aggregate future minimum non-cancellable 2019 723 2020 736 2021 488 Future minimum lease payments, net $ 1,947

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2019
Text Block [Abstract]
Stock-Based Compensation Expense on All Employee and Non-Employee Awards	The Company recognized stock-based compensation expense on all employee and non-employee For the three months ended June 30, For the six months ended June 30, (in thousands) 2019 2018 2019 2018 Research and development $ 297 $ 609 $ 729 $ 1,212 General and administrative 1,502 1,102 2,526 4,158 Stock-based compensation expense $ 1,799 $ 1,711 $ 3,255 $ 5,370
Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model	For the three months ended June 30, 2019 and 2018, the fair value of stock options was estimated on the date of grant using a Black-Scholes option valuation model with the following assumptions: For the three months ended June 30, 2019 2018 Risk-free interest rate 1.89 - 2.42% 2.66 - 2.91% Expected life in years 5.75 - 6.25 6 Expected volatility 72.68 - 78.85% 81.48 - 81.66% Expected dividend yield 0 0
Stock Option Activity under Stock Option Plan	Stock option activity under the Company’s stock option plan for the six months ended June 30, 2019 is as follows: (in thousands, except share and per share data) Number of Weighted- Weighted- Aggregate Outstanding, December 31, 2018 5,277,085 $ 4.24 Granted 1,695,755 2.54 Exercised (332,416 ) 2.95 Cancelled (1,562,833 ) 4.14 Outstanding, June 30, 2019 5,077,591 $ 3.78 7.91 $ 12,463 Options exercisable, June 30, 2019 2,378,158 $ 4.90 5.93 $ 4,220 Options exercisable, December 31, 2018 3,099,935 $ 5.15 4.93 $ 88 Options available for future grant 4,069,982
Summary of Unvested Restricted Stock	A summary of the status of unvested restricted stock for the six months ended June 30, 2019 is as follows: Number of Shares Weighted-Average Non-vested, 682,070 $ 3.47 Granted 1,393,536 2.24 Vested (446,428 ) 2.24 Cancelled (74,599 ) 3.41 Non-vested, 1,554,579 $ 2.90

Business - Additional Informati

Business - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	6 Months Ended
	Jul. 31, 2019	Jun. 30, 2019	Jul. 29, 2019	Dec. 31, 2018
Cash and cash equivalents		$ 43,563		$ 61,729
Accumulated deficit		(594,383)		$ (566,329)
Research and development expense related to joint venture		$ 35,000
Private Placement [Member]
Number of securities into which the class of warrant converted		18,939,394
Warrant Exercise Per share		$ 3.01
Subsequent Event [Member]
Proceeds from private placement	$ 45,000
Subsequent Event [Member] | Private Placement [Member]
Number of securities into which the class of warrant converted			15,015,152
Warrant Exercise Per share			$ 3.01
Subsequent Event [Member] | New Warrants [Member] | Private Placement [Member]
Number of securities into which the class of warrant converted			15,015,152
Warrant Exercise Per share			$ 7

Summary of Significant Accoun_3

Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands	Jun. 30, 2019USD ($)
Summary Of Significant Accounting Policies [Line Items]
Total operating lease liabilities	$ 1,438
Operating Lease, Right-of-Use Asset	$ 1,438
Lessee, Operating Lease, Term of Contract	12 months
ASU 2016-02
Summary Of Significant Accounting Policies [Line Items]
Total operating lease liabilities	$ 1,600
Operating Lease, Right-of-Use Asset	$ 1,600

Assets and Liabilities Measured

Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 24,706	$ 24,437
Quoted Prices in Active Markets for Identical Assets/Liabilities (Level 1)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 24,706	$ 24,437

Potential Dilutive Shares Exclu

Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail) - shares	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	26,071,564	47,256,724
Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	18,939,394
Stock Options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	5,077,591	4,303,802
Stock Options | Two Thousand Twelve Stock Option Plan [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	500,000
Unvested Restricted Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	1,554,579	1,198,868
Series 1 Preferred Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount		41,754,054

Revenue Recognition - Additiona

Revenue Recognition - Additional Information (Detail) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018	Jan. 01, 2018	May 31, 2015
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Accumulated deficit	$ (594,383)		$ (566,329)
Collaboration revenue		$ 146
Difference between Revenue Guidance in Effect before and after Topic 606
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Accumulated deficit				$ 8,100
ARES Trading License
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Deferred revenue, upfront payment					$ 57,500
ARES Trading License | Difference between Revenue Guidance in Effect before and after Topic 606
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	0
License Agreement With Precigen
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	$ 0

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) $ in Thousands

May 28, 2019USD ($)

Oct. 05, 2018USD ($)

Jan. 13, 2015USD ($)

Aug. 24, 2004USD ($)Patent

Jul. 31, 2015USD ($)

Jun. 30, 2019USD ($)

Jun. 30, 2018USD ($)

Mar. 31, 2018USD ($)

Jun. 30, 2019USD ($)

Jun. 30, 2018USD ($)

Dec. 31, 2018USD ($)

Dec. 31, 2017

Nov. 28, 2020USD ($)

Feb. 19, 2019USD ($)

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 9,998

$ 7,489

$ 19,474

$ 17,672

Research and development arrangement Terms

Pursuant to the Research and Development Agreement, the Company, Precigen and MD Anderson formed a joint steering committee to oversee and manage the new and ongoing research programs. Under the License Agreement with Precigen, the Company and Precigen agreed that Precigen would no longer participate on the joint steering committee after the date of the License Agreement. As provided under the MD Anderson License, the Company provided funding for research and development activities in support of the research programs under the Research and Development Agreement for a period of three years and in an amount of no less than $15.0 million and no greater than $20.0 million per year.

Cash balance

43,563

43,563

$ 61,729

Agreement commencement date

2015-05

MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Research and development service agreement aggregate quarterly payments

3,000

2,200

Cash resources on hand

24,200

27,800

24,200

27,800

CRADA Agreement [Member]

Commitments and Contingencies Disclosure [Line Items]

Obligations due under contract

$ 5,000

Remaining contractual obligation

$ 6,300

Quarterly payments under contract

600

$ 600

1,300

1,300

Gorilla IL12 Products [Member] | Parent [Member]

Commitments and Contingencies Disclosure [Line Items]

Percentage of development costs

80.00%

Percentage of operating profits

80.00%

CAR Products [Member]

Commitments and Contingencies Disclosure [Line Items]

Amount of royalties receivable

$ 50,000

The University of Texas MD Anderson Cancer Center and The Texas A & M University System

Commitments and Contingencies Disclosure [Line Items]

Milestone maximum payment

$ 4,500

Number of products | Patent

2

ARES Trading License

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

36

0

36

License Agreement with the National Cancer Institute [Member]

Commitments and Contingencies Disclosure [Line Items]

Reimbursement of historical costs

$ 46

Expected Cash Payment Payable

1,500

Minimum Royalties Amount Payable

$ 300

Description Of First Annual Royalty Payable

The first minimum annual royalty payment is payable on the date that is eighteen months following the date of the Patent License

Description Of First Benchmark Payable

The first benchmark payment of $0.1 million will be due upon the initiation of the Company’s first sponsored phase 1 clinical trial of a licensed product or licensed process in the field of use licensed under the Patent License.

Description Of option To terminate Agreement

The NCI may terminate or modify the Patent License in the event of a material breach, including if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event

Agreement termination, notice period

60 days

License Agreement with the National Cancer Institute [Member] | Performance Based Payments Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Aggregate Benchmark Payments Payable

$ 4,300

License Agreement with the National Cancer Institute [Member] | One Time Benchmark Payments [Member]

Commitments and Contingencies Disclosure [Line Items]

Potential Benchmark Payments Payable

12,000

License Agreement with the National Cancer Institute [Member] | Scenario, Forecast [Member]

Commitments and Contingencies Disclosure [Line Items]

Expected Cash Payment Payable

$ 1,500

Minimum Royalties Amount Payable

$ 100

License Agreement with the National Cancer Institute [Member] | Due With In One Eighty Days [Member]

Commitments and Contingencies Disclosure [Line Items]

Expected Cash Payment Payable

500

License Agreement with the National Cancer Institute [Member] | Due With In One Eighty Days to Three Sixty Days [Member]

Commitments and Contingencies Disclosure [Line Items]

Expected Cash Payment Payable

500

License Agreement with the National Cancer Institute [Member] | Post Marketing Approval [Member] | Performance Based Payments Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Aggregate Benchmark Payments Payable

3,000

License Agreement with the National Cancer Institute [Member] | licensed products [Member] | One Time Benchmark Payments [Member]

Commitments and Contingencies Disclosure [Line Items]

Maximum Sales Revenue On Which Benchmark Payments Payable

$ 1,000,000

Prepaid Expenses and Other Current Assets | MD Anderson License

Commitments and Contingencies Disclosure [Line Items]

Cash balance

19,400

18,400

19,400

18,400

Other Noncurrent Assets | MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Cash resources on hand

4,800

4,800

Other Noncurrent Assets | MD Anderson License

Commitments and Contingencies Disclosure [Line Items]

Cash balance

4,800

$ 9,400

4,800

$ 9,400

Current Liabilities [Member] | License Agreement with the National Cancer Institute [Member]

Commitments and Contingencies Disclosure [Line Items]

Reimbursement of historical costs

46

46

Expected Cash Payment Payable

$ 1,500

$ 1,500

Intrexon Corporation

Commitments and Contingencies Disclosure [Line Items]

Licensing fee

$ 115,000

Research and development expense

$ 1,000

Upfront payment received

$ 57,500

Percentage of upfront fee Payable

50.00%

Annual Licensing fee

100

Reimbursement of historical costs

1,000

Expected additional milestones payable

$ 52,500

Intrexon Corporation | Gorilla IL12 Products [Member]

Commitments and Contingencies Disclosure [Line Items]

Percentage of development costs

20.00%

Percentage of operating profits

20.00%

Intrexon Corporation | T-cell receptor

Commitments and Contingencies Disclosure [Line Items]

Maximum royalty amount

$ 100,000

Portion of income payable to related party

20.00%

Minimum | MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 15,000

Maximum | MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 20,000

Related Party Transactions - Ad

Related Party Transactions - Additional Information (Detail) - USD ($)	Jun. 29, 2016	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018	Dec. 31, 2015
Related Party Transaction [Line Items]
Change in fair value of derivative liability			$ 183,000		$ 211,000
Amounts expensed for services incurred		$ 14,753,000	12,378,000	$ 28,374,000	28,720,000
Research and development expense		9,998,000	7,489,000	19,474,000	17,672,000
MD Anderson License and the Research and Development Agreement Member [Member]
Related Party Transaction [Line Items]
Research and development service agreement aggregate quarterly payments				3,000,000	2,200,000
Cash resources on hand		24,200,000	27,800,000	24,200,000	27,800,000
MD Anderson License and the Research and Development Agreement Member [Member] | Other Current Assets [Member]
Related Party Transaction [Line Items]
Cash resources on hand		19,400,000		19,400,000
MD Anderson License and the Research and Development Agreement Member [Member] | Other Noncurrent Assets [Member]
Related Party Transaction [Line Items]
Cash resources on hand		4,800,000		4,800,000
Series 1 Preferred Stock
Related Party Transaction [Line Items]
Temporary equity, fair value		5,400,000		5,400,000
Change in fair value of derivative liability					200
License Agreement | M.D. Anderson Cancer Center
Related Party Transaction [Line Items]
Issuance of common stock in licensing agreement (in shares)							11,722,163
Research and development expense							$ 67,300,000
Cooperative Research and Development Agreement | M.D. Anderson Cancer Center
Related Party Transaction [Line Items]
Research and development service agreement aggregate quarterly payments					2,700,000
Research and development service agreement aggregate payments					41,900,000
Intrexon Corporation/Precigen
Related Party Transaction [Line Items]
Amounts expensed for services incurred				1,500,000	4,700,000
Amount due to related party, current		$ 1,100,000	$ 1,900,000	$ 1,100,000	$ 1,900,000
Research and development expense						$ 1,000,000
Intrexon Corporation/Precigen | Series 1 Preferred Stock
Related Party Transaction [Line Items]
Issuance of common stock in licensing agreement (in shares)	100,000		3,734

Settlement of a Related Party_2

Settlement of a Related Party Relationship - Additional Information (Detail) - USD ($) $ in Thousands	Oct. 05, 2018	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Transaction advisory costs recognized as expense						$ 2,000
Research and development expense		$ 9,998	$ 7,489	$ 19,474	$ 17,672
Accrued expenses		$ 8,799		$ 8,799		8,763
Gorilla IL-12 Products
Percentage of development cost shared by other party	80.00%
Percentage of operating profit shared by other party	80.00%
Intrexon Corporation/Precigen
Annual Licensing fee	$ 100
Reimbursement of historical costs	1,000
Preferred stock, contract liability, derivative liability	163,300
Increase in accumulated deficit	49,500
Related party transaction, amounts of transaction	212,800
Research and development expense						$ 1,000
Additional milestone payment for exclusively licensed program to be paid	52,500
Maximum Royalty payable	$ 100,000
Percentage of sublicensing income	20.00%
Royalty payment to be received	$ 50,000
Intrexon Corporation/Precigen | Gorilla IL-12 Products
Percentage of development cost shared by other party	20.00%
Percentage of operating profit shared by other party	20.00%
Third Party Vendor
Transaction advisory costs recognized as expense	$ 7,400
Series 1 Preferred Stock [Member]
Transaction advisory costs recognized as expense	5,400
Series 1 Preferred Stock [Member] | Intrexon Corporation/Precigen
Consideration transferred	207,300
Preferred Stock Redemption Discount	$ 5,400

Lease expense (Detail)

Lease expense (Detail) $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2019USD ($)	Jun. 30, 2019USD ($)
Operating lease cost	$ 182	$ 360
Total lease cost	$ 182	$ 360
Weighted-average remaining lease term (years)	2 years 4 months 24 days	2 years 4 months 24 days
Weighted-average discount rate	8.00%	8.00%

Operating lease liabilities (De

Operating lease liabilities (Detail) $ in Thousands	Jun. 30, 2019USD ($)
2019 (excluding the six months ended June 30, 2019)	$ 373
2020	755
2021	491
Total lease payments	1,619
Less: Imputed Interest and Adjustments	181
Present value of lease payments	$ 1,438

Future minimum current and non-

Future minimum current and non-current lease liabilities (Detail) $ in Thousands	Dec. 31, 2018USD ($)
2019	$ 723
2020	736
2021	488
Future minimum lease payments, net	$ 1,947

Leases - Additional Information

Leases - Additional Information (Details) $ in Thousands	Mar. 12, 2019USD ($)ft²	Jun. 30, 2018USD ($)	Jun. 30, 2019USD ($)	Jun. 30, 2018USD ($)	Jan. 01, 2019USD ($)	Dec. 31, 2018USD ($)	Jan. 30, 2018USD ($)ft²
Land Subject to Ground Leases | ft²	1,038
Lessee Operating Lease Monthly Average Rental Payment	$ 2
Operating Lease, Payments			$ 400
Total rent expense		$ 200		$ 400
Security Deposit			2
Operating Lease, Right-of-Use Asset			1,438
Operating Lease, Liability			1,438
Boston, MA
Security Deposit			$ 100			$ 100
Sublease term amendment			Aug. 31, 2021
Operating lease expiration month and year			2016-08
Houston, TX
Operating Lease Area | ft²							210
Operating Leases Future Minimum Monthly Payment Due Through Year 2021							$ 1
Adjustments for New Accounting Pronouncement [Member]
Operating Lease, Right-of-Use Asset					$ 1,600
Operating Lease, Liability					$ 1,600

Stock-Based Compensation Expens

Stock-Based Compensation Expense Included in Statement of Operations (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	$ 1,799	$ 1,711	$ 4,255	$ 5,370
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	297	609	729	1,212
General and Administrative Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	$ 1,502	$ 1,102	$ 2,526	$ 4,158

Stock-Based Compensation - Addi

Stock-Based Compensation - Additional Information (Detail) - USD ($)	Jan. 06, 2019	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Jun. 13, 2019	May 12, 2018	Feb. 15, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock options, granted		199,422	198,000	1,695,755	205,500
Weighted-average grant date fair value		$ 3.13	$ 3.06	$ 1.80	$ 3.06
Number of shares issued for accrued annual performance bonus	446,428
Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended contractual life						52,500	117,500
Director One [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended contractual life						126,700
Additional stock-based compensation expense		$ 400,000	$ 500,000	$ 400,000	$ 500,000
Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended contractual life								751,667
Unvested Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation costs related to unvested restricted stock outstanding		5,600,000		$ 5,600,000
Expected recognition period				1 year 6 months 29 days
Unvested Restricted Common Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation costs related to unvested restricted stock outstanding		$ 3,300,000		$ 3,300,000
Expected recognition period				1 year 6 months 14 days

Fair Value of Stock Options Ass

Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model (Detail)	3 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Risk-free interest rate, Minimum	1.89%	2.66%
Risk-free interest rate, Maximum	2.42%	2.91%
Expected life in years		6 years
Expected volatility, Minimum	72.68%	81.48%
Expected volatility, Maximum	78.85%	81.66%
Expected dividend yield	0.00%	0.00%
Maximum [Member]
Expected life in years	6 years 3 months
Minimum [Member]
Expected life in years	5 years 9 months

Stock Option Activity Under Sto

Stock Option Activity Under Stock Option Plan (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Number of Shares
Beginning Balance			5,277,085
Granted	199,422	198,000	1,695,755	205,500
Exercised			(332,416)
Cancelled			(1,562,833)
Ending Balance	5,077,591		5,077,591		5,277,085
Options exercisable, at end of period	2,378,158		2,378,158		3,099,935
Options available for future grant	4,069,982		4,069,982
Weighted Average Exercise Price
Beginning Balance			$ 4.24
Granted			2.54
Exercised			2.95
Cancelled			4.14
Ending Balance	$ 3.78		3.78		$ 4.24
Options exercisable, at end of period	$ 4.90		$ 4.90		$ 5.15
Weighted Average Contractual Term (Years)
Outstanding, at end of period			7 years 10 months 27 days
Options exercisable, at end of period			5 years 11 months 4 days		4 years 11 months 4 days
Aggregate Intrinsic Value
Outstanding, at end of period	$ 12,463		$ 12,463
Options exercisable, at end of period	$ 4,220		$ 4,220		$ 88

Summary of Non-Vested Restricte

Summary of Non-Vested Restricted Stock (Detail) - Unvested Restricted Common Stock	6 Months Ended
	Jun. 30, 2019$ / sharesshares
Number of Shares
Beginning Balance | shares	682,070
Granted | shares	1,393,536
Vested | shares	(446,428)
Cancelled | shares	(74,599)
Ending Balance | shares	1,554,579
Weighted Average Grant Date Fair Value
Beginning Balance | $ / shares	$ 3.47
Granted | $ / shares	2.24
Vested | $ / shares	2.24
Cancelled | $ / shares	3.41
Ending Balance | $ / shares	$ 2.90

Preferred Stock - Additional In

Preferred Stock - Additional Information (Detail) - Intrexon Corporation/Precigen - Series 1 Preferred Stock - $ / shares	Jun. 29, 2016	Jun. 30, 2018
Equity [Line Items]
Issuance of common stock in licensing agreement (in shares)	100,000	3,734
Preferred stock, stated value	$ 1,200

Warrants - Additional Informati

Warrants - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019
Fair Value Assumptions Expected volatility Rate Maximum	78.85%	81.66%
Fair Value Assumptions Risk Free Interest Rate Maximum	2.42%	2.91%
Fair Value Assumptions Expected Term1		6 years
Fair Value Assumptions Expected Dividend Rate	0.00%	0.00%
Securities Purchase Agreement [Member]
Gross proceeds received			$ 47.1
Private Placement [Member]
Number of securities into which the class of warrant converted	18,939,394		18,939,394
Warrant Exercise Per share	$ 3.01		$ 3.01
fair value of adjustment of warrants			$ 18.4
Fair Value Assumptions Expected volatility Rate Maximum			71.00%
Fair Value Assumptions Risk Free Interest Rate Maximum			2.99%
Fair Value Assumptions Expected Term1			5 years
Fair Value Assumptions Expected Dividend Rate			0.00%