Alaunos Therapeutics (TCRT) 10-Q 7 Nov 19 2019 Q3 Quarterly report Financial data

Cover Page

Cover Page - shares	9 Months Ended
	Sep. 30, 2019	Oct. 31, 2019
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Sep. 30, 2019
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q3
Entity Registrant Name	ZIOPHARM ONCOLOGY INC
Entity Central Index Key	0001107421
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Trading Symbol	ZIOP
Entity Emerging Growth Company	false
Entity Small Business	true
Entity Common Stock, Shares Outstanding		181,030,020
Entity Interactive Data Current	Yes
Title of 12(b) Security	Common Stock
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Shell Company	false
Entity Address, State or Province	MA

BALANCE SHEETS

BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 88,419	$ 61,729
Receivables	3,441	1,864
Prepaid expenses and other current assets	23,739	20,692
Total current assets	115,599	84,285
Property and equipment, net	828	1,097
Operating lease right of use assets	1,283
Deposits	130	128
Other non-current assets	109	9,541
Total assets	117,949	95,051
Current liabilities:
Accounts payable	926	707
Accrued expenses	9,573	8,763
Lease liability—current portion	677
Deferred rent—current portion		13
Total current liabilities	11,176	9,483
Lease liability—noncurrent portion	647
Deferred rent—noncurrent portion		4
Total liabilities	11,823	9,487
Commitments and contingencies (Note 7)
Stockholders' equity:
Common stock, $0.001 par value; 250,000,000 shares authorized; 181,030,020 and 161,066,136 shares issued and outstanding at September 30, 2019 and December 31, 2018, respectively	181	161
Additional paid-in capital	774,324	651,732
Accumulated deficit	(668,379)	(566,329)
Total stockholders' equity	106,126	85,564
Total liabilities and stockholders' equity	$ 117,949	$ 95,051

BALANCE SHEETS (Parenthetical)

BALANCE SHEETS (Parenthetical) - $ / shares	Sep. 30, 2019	Dec. 31, 2018
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	250,000,000	250,000,000
Common stock, shares issued	181,030,020	161,066,136
Common stock, shares outstanding	181,030,020	161,066,136

STATEMENTS OF OPERATIONS

STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Income Statement [Abstract]
Collaboration revenue				$ 146
Operating expenses:
Research and development	$ 8,641	$ 8,263	$ 28,115	25,935
General and administrative	4,807	4,307	13,707	15,355
Total operating expenses	13,448	12,570	41,822	41,290
Loss from operations	(13,448)	(12,570)	(41,822)	(41,144)
Other income, net	203	150	523	462
Change in fair value of derivative liabilities		(165)		46
Non-cash inducement warrant expense	(60,751)		(60,751)
Net loss	(73,996)	(12,585)	(102,050)	(40,636)
Preferred stock dividends		(6,074)		(16,656)
Net loss applicable to common stockholders	$ (73,996)	$ (18,659)	$ (102,050)	$ (57,292)
Basic and diluted net loss per share	$ (0.43)	$ (0.13)	$ (0.62)	$ (0.41)
Weighted average common shares outstanding used to compute basic and diluted net loss per share	170,613,712	141,185,404	164,053,029	141,020,025

STATEMENTS OF CHANGES IN PREFER

STATEMENTS OF CHANGES IN PREFERRED STOCK AND STOCKHOLDERS' Equity (DEFICIT) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid In Capital Common Stock	Accumulated Deficit	Series 1 Preferred Stock - Mezzanine
Balance at Dec. 31, 2017	$ (96,806)	$ 143	$ 615,493	$ (712,442)	$ 143,992
Balance (in shares) at Dec. 31, 2017		142,658,037			119,644
Adjustment for implementation of ASU No. 2014-09, Revenue from contracts with customers	(8,131)			(8,131)
Stock-based compensation	6,850		6,850
Exercise of employee stock options	240		240
Exercise of employee stock options (in shares)		104,166
Cancelled restricted common stock (in shares)		(70,867)
Repurchase of restricted common stock	(1,275)	$ (1)	(1,274)
Repurchase of restricted common stock (Shares)		(311,566)
Preferred stock dividends			(16,656)		$ 16,437
Preferred stock dividends	(16,656)
Preferred stock dividends (in shares)					11,205
Net loss	(40,636)			(40,636)
Balance at Sep. 30, 2018	(156,414)	$ 142	604,653	(761,209)	$ 160,429
Balance (in shares) at Sep. 30, 2018		142,379,770			130,849
Balance at Jun. 30, 2018	(139,235)	$ 142	609,247	(748,624)	$ 154,428
Balance (in shares) at Jun. 30, 2018		142,379,770			127,002
Stock-based compensation	1,480		1,480
Preferred stock dividends			(6,074)		$ 6,001
Preferred stock dividends	(6,074)
Preferred stock dividends (in shares)					3,847
Net loss	(12,585)			(12,585)
Balance at Sep. 30, 2018	(156,414)	$ 142	604,653	(761,209)	$ 160,429
Balance (in shares) at Sep. 30, 2018		142,379,770			130,849
Balance at Dec. 31, 2018	85,564	$ 161	651,732	(566,329)
Balance (in shares) at Dec. 31, 2018		161,066,136
Stock-based compensation	4,741		4,741
Exercise of employee stock options	$ 1,020		1,020
Exercise of employee stock options (in shares)	482,500	352,652
Restricted stock awards	$ 1,000	$ 1	999
Restricted stock awards (in shares)		1,408,536
Issuance of common stock upon exercise of warrants, net	52,499	$ 18	52,481
Issuance of common stock upon exercise of warrants, net (in shares)		17,803,031
Issuance of inducement warrants	60,751		60,751
Cancelled restricted common stock (in shares)		(74,599)
Restricted stock buy-back at vesting to cover taxes	(370)		(370)
Restricted stock buy-back at vesting to cover taxes (in shares)		(165,178)
Issuance of common stock in connection with at the market offering, net	2,971	$ 1	2,970
Issuance of common stock in connection with at the market offering, net (in shares)		639,442
Net loss	(102,050)			(102,050)
Balance at Sep. 30, 2019	106,126	$ 181	774,324	(668,379)
Balance (in shares) at Sep. 30, 2019		181,030,020
Balance at Jun. 30, 2019	61,995	$ 162	656,216	(594,383)
Balance (in shares) at Jun. 30, 2019		162,477,963
Stock-based compensation	1,486		1,486
Exercise of employee stock options	420		420
Exercise of employee stock options (in shares)		94,584
Restricted stock awards (in shares)		15,000
Issuance of common stock upon exercise of warrants, net	52,499	$ 18	52,481
Issuance of common stock upon exercise of warrants, net (in shares)		17,803,031
Issuance of inducement warrants	60,751		60,751
Issuance of common stock in connection with at the market offering, net	2,971	$ 1	2,970
Issuance of common stock in connection with at the market offering, net (in shares)		639,442
Net loss	(73,996)			(73,996)
Balance at Sep. 30, 2019	$ 106,126	$ 181	$ 774,324	$ (668,379)
Balance (in shares) at Sep. 30, 2019		181,030,020

STATEMENTS OF CASH FLOWS

STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Cash flows from operating activities:
Net loss	$ (102,050)	$ (40,636)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	453	412
Stock-based compensation	5,741	6,850
Change in fair value of derivative liabilities		(46)
Non-cash inducement warrant expense	60,751
(Increase) decrease in:
Receivables	(1,577)	(1,002)
Prepaid expenses and other current assets	(3,047)	5,406
Other noncurrent assets	9,432	(4,684)
Deposits	(2)
Increase (decrease) in:
Accounts payable	219	(3,148)
Accrued expenses	810	(532)
Deferred revenue		(146)
Deferred rent	17	(112)
Other liabilities	7
Net cash used in operating activities	(29,246)	(37,638)
Cash flows from investing activities:
Purchases of property and equipment	(184)	(545)
Net cash used in investing activities	(184)	(545)
Cash flows from financing activities:
Proceeds from exercise of stock options	1,020	240
Repurchase of common stock	(370)	(1,275)
Issuance of common stock in connection with at the market offering, net	2,971
Issuance of common stock upon exercise of warrants, net	52,499
Net cash provided by (used in) financing activities	56,120	(1,035)
Net increase (decrease) in cash and cash equivalents, and restricted cash	26,690	(39,218)
Cash and cash equivalents, and restricted cash, beginning of period	61,729	71,335
Cash and cash equivalents, and restricted cash, end of period	88,419	32,117
Supplementary disclosure of cash flow information:
Compensation paid in restricted stock, gross	$ 1,000
Series 1 Preferred Stock
Supplementary disclosure of noncash investing and financing activities:
Payment of dividends in preferred stock		$ 16,656

Business

Business	9 Months Ended
	Sep. 30, 2019
Accounting Policies [Abstract]
Business	1. Business Overview ZIOPHARM Oncology, Inc., which is referred to herein as “ZIOPHARM,” or the “Company,” is a biopharmaceutical company seeking to develop, acquire, and commercialize, on its own or with partners, a diverse portfolio of immuno-oncology therapies . The Company’s operations to date have consisted primarily of conducting research and development and raising capital to fund those efforts. The Company’s fiscal year ends on December 31. The Company has operated at a loss since its inception in 2003 and has no recurring revenues from operations. The Company anticipates that losses will continue for the foreseeable future. As of September 30, 2019, the Company had approximately $88.4 million of cash and cash equivalents and the Company’s accumulated deficit was approximately $668.4 million. Given its current development plans, the Company anticipates cash resources will be sufficient to fund operations into the first half of 2021. The Company’s ability to continue operations after its current cash resources are exhausted depends on its ability to obtain additional financing or to achieve profitable operations, as to which no assurances can be given. Cash requirements may vary materially from those now planned because of changes in the Company’s focus and direction of its research and development programs, competitive and technical advances, patent developments, regulatory changes or other developments. If adequate additional funds are not available when required, or if the Company is unsuccessful in entering into partnership agreements for further development of its product candidates, management may need to curtail its development efforts and planned operations to conserve cash. Basis of Presentation The accompanying unaudited interim financial statements have been prepared in accordance with the instructions to Form 10-Q It is management’s opinion that the accompanying unaudited interim financial statements reflect all adjustments (which are normal and recurring) that are necessary for a fair statement of the results for the interim periods. The unaudited interim financial statements should be read in conjunction with the audited financial statements and the notes thereto for the year ended December 31, 2018, included in the Company’s Annual Report on Form 10-K 10-K. The year-end The results disclosed in the statements of operations for the three and nine months ended September 30, 2019 are not necessarily indicative of the results to be expected for the full fiscal year. Use of Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Although the Company regularly assesses these estimates, actual results could differ from those estimates. Changes in estimates are recorded in the period in which they become known. The Company’s most significant estimates and judgments used in the preparation of its financial statements are: • Clinical trial expenses; • Collaboration agreements and revenue recognition; • Fair value measurements of stock-based compensation and Series 1 preferred stock; and • Income taxes Subsequent Events The Company evaluated all events and transactions that occurred after the balance sheet date through the date of this filing. Except as disclosed below, the Company did not have any material subsequent events that impacted its financial statements or disclosures. On October 22, 2019, the Company entered into the 2019 Research and Development Agreement, or the 2019 Agreement, with The University of Texas M.D. Anderson Cancer Center, or MD Anderson , the Company’s Sleeping Beauty non-viral the Company’s TCR library and conduct clinical trials. The Company will own all intellectual property developed under the 2019 Agreement and will retain all rights to intellectual property for oncology products manufactured using non-viral Sleeping Beauty non-exclusive The Company has agreed, beginning on January 1, 2021, to reimburse MD Anderson up to a total of $20.0 million for development costs under the 2019 Agreement. In addition, the Company will pay MD Anderson royalties on net sales of its TCR products at rates in the low single digits. The Company is required to make performance-based payments upon the successful completion of clinical and regulatory benchmarks relating to its TCR products. The aggregate potential benchmark payments are $36.5 million, of which only $3.0 million will be due prior to the first marketing approval of the Company’s TCR products. The royalty rates and benchmark payments owed to MD Anderson may be reduced upon the occurrence of certain events. The Company also agreed that it will sell the Company’s TCR products to MD Anderson at preferential prices and will sell its TCR products in Texas exclusively to MD Anderson for a limited period of time following the first commercial sale of the Company’s TCR products. The 2019 Agreement will terminate on December 31, 2026 and either party may terminate the 2019 Agreement following written notice of a material breach. The 2019 Agreement also contains customary provisions related to indemnification obligations, confidentiality and other matters. In connection with the execution of the 2019 Agreement, on October 22, 2019, the Company issued MD Anderson a warrant to purchase 3,333,333 shares of our common stock, or the Warrant. The Warrant has an initial exercise price of $0.001 per share, expires on December 31, 2026 and vests upon the occurrence of certain clinical milestones. Also, in connection with the execution of the 2019 Agreement, on October 22, 2019, the Company and MD Anderson entered into the Fifth Amendment to the , by and Company and MD Anderson , or , 2015 the Company’s chimeric antigen receptor (CAR-T) 2015 2015 2019

Financings

Financings	9 Months Ended
	Sep. 30, 2019
Text Block [Abstract]
Financings	2. Financings At-the-Market During the three and nine months ended September 30, 2019, the Company sold an aggregate of 639,442 shares of its common stock. The offering was made pursuant to the Company’s effective registration statement on Form S-3ASR November 2018 Private Placement and 2019 Inducement Warrants On November 11, 2018, the Com pany pursuant which it sold to such investors the Company the Company the Company S-3 On July 26, 2019 and September 1 2 s d as an inducement for warrant holders to exercise their 2018 warrants early. The new ( Note 14). exercise of the warr a fees rel a

Summary of Significant Accounti

Summary of Significant Accounting Policies	9 Months Ended
	Sep. 30, 2019
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	3. Summary of Significant Accounting Policies The Company’s significant accounting policies were identified in the Company’s Form 10-K. 10-K Leases In February 2016, the FASB issued ASU 2016-02, right-of-use The standard permits two transition methods, (1) to apply the new lease requirements at the beginning of the earliest period presented, or (2) to apply the new lease requirements at the effective date. The Company adopted Topic 842 as of January 1, 2019 using the effective date method, in which it did not restate prior periods. Upon adoption, the Company elected the package of practical expedients permitted under the transition guidance within Topic 842 which, among other things, allowed it to carry forward the historical lease classification. The adoption of Topic 842 on January 1, 2019 resulted in recognition of approximately $1.6 million of right-of-use New Accounting Pronouncements In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement 2018-03. In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting 2018-07. Variable Interest Entities The Company reviews each legal entity formed by parties related to the Company to determine whether or not the entity is a Variable Interest Entity, or VIE. If the entity is a VIE, the Company assesses whether or not it is the primary beneficiary of that VIE based on a number of factors, including (i) which party has the power to direct the activities of the VIE that most significantly affect its economic performance, (ii) the parties’ contractual rights and responsibilities pursuant to any contractual agreements and (iii) which party has the obligation to absorb losses or the right to receive benefits from the VIE. If the Company determines that it is the primary beneficiary of a VIE, it consolidates the financial statements of the VIE into its consolidated financial statements at the time that determination is made. The Company evaluates whether it continues to be the primary beneficiary of any consolidated VIEs on a quarterly basis. If the Company determines that it is no longer the primary beneficiary of a consolidated VIE, or no longer has a variable interest in the VIE, the Company deconsolidates the VIE in the period that the determination is made .

Fair Value Measurements

Fair Value Measurements	9 Months Ended
	Sep. 30, 2019
Fair Value Disclosures [Abstract]
Fair Value Measurements	4. Fair Value Measurements The Company accounts for its financial assets and liabilities using fair value measurements. The authoritative accounting guidance defines fair value, establishes a framework for measuring fair value under generally accepted accounting principles and enhances disclosures about fair value measurements. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The fair value hierarchy is based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value as follows: • Level 1—Quoted prices in active markets for identical assets or liabilities. • Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. Assets and liabilities measured at fair value on a recurring basis as of September 30, 2019 and December 31, 2018 were as follows: ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 73,198 $ 73,198 $ — $ — ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 24,437 $ 24,437 $ — $ — The cash equivalents represent deposits in short-term United States treasury money market mutual fund s .

Net Loss per Share

Net Loss per Share	9 Months Ended
	Sep. 30, 2019
Earnings Per Share [Abstract]
Net Loss per Share	5. Net Loss per Share Basic net loss per share is computed by dividing net loss by the weighted average number of shares of common stock outstanding for the period. The Company’s potentially dilutive shares, which include outstanding common stock options, unvested restricted stock and preferred stock, have not been included in the computation of diluted net loss per share for any of the periods presented as the result would be anti-dilutive. Such potentially dilutive shares of common stock at September 30, 2019 and 2018 consisted of the following: September 30, 2019 2018 Stock options 4,995,549 4,569,468 Inducement stock options 965,000 — Unvested restricted stock 1,569,579 1,164,352 Warrants 18,939,394 — Preferred stock — 52,583,921 26,469,522 58,317,741 On October 5, 2018, the Company and Precigen, Inc., or Precigen, a wholly owned subsidiary of Intrexon Corporation, or Intrexon, entered into an exclusive license agreement, or the License Agreement, to replace all existing agreements between the companies that provides the Company with certain exclusive and non-exclusive 9 .

Revenue Recognition

Revenue Recognition	9 Months Ended
	Sep. 30, 2019
Revenue from Contract with Customer [Abstract]
Revenue Recognition	6. Revenue Recognition The Company adopted Accounting Standards Codification, or ASC Topic 606, Revenue from Contracts with Customers, The Company primarily generates revenue through collaboration arrangements with strategic partners for the development and commercialization of product candidates. Commencing January 1, 2018, the Company recognized revenue in accordance with ASC 606 which replaced ASC 605, Multiple Element Arrangements The Company recognizes collaboration revenue under certain of the Company’s license or collaboration agreements that are within the scope of ASC 606. The Company’s contracts with customers typically include promises related to licenses to intellectual property, research and development services and options to purchase additional goods and/or services. If the license to the Company’s intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, the Company recognizes revenue from non-refundable, up-front non-refundable, up-front The terms of the Company’s arrangements with customers typically include the payment of one or more of the following: (i) non-refundable, up-front catch-up The Company allocates the transaction price to each performance obligation identified in the contract on a relative standalone selling price basis. However, certain components of variable consideration are allocated specifically to one or more particular performance obligations in a contact to the extent both of the following criteria are met: (i) the terms of the payment relate specifically to the efforts to satisfy the performance obligation or transfer the distinct good or service and (ii) allocating the variable amount of consideration entirely to the performance obligation or the distinct good or service is consistent with the allocation objective of the standard whereby the amount allocated depicts the amount of consideration to which the entity expects to be entitled in exchange for transferring the promised goods or services. The Company develops assumptions that require judgment to determine the standalone selling price for each performance obligation identified in each contract. The key assumptions utilized in determining the standalone selling price for each performance obligation may include forecasted revenues, development timelines, estimated research and development costs, discount rates, likelihood of exercise and probabilities of technical and regulatory success. Revenue is recognized based on the amount of the transaction price that is allocated to each respective performance obligation when or as the performance obligation is satisfied by transferring a promised good and/or service to the customer. For performance obligations that are satisfied over time, the Company recognizes revenue by measuring the progress toward complete satisfaction of the performance obligation using a single method of measuring progress which depicts the performance in transferring control of the associated goods and/or services to the customer. The Company uses input methods to measure the progress toward the complete satisfaction of performance obligations satisfied over time. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. Any such adjustments are recorded on a cumulative catch-up As it relates to the Ares Trading Agreement (Note 6), the Company recognized the upfront payment associated with its one open contract as a contract liability upon receipt of payment as it requires deferral of revenue recognition to a future period until the Company performs its obligations under the arrangement. The Company determined that there were three performance obligations; the first performance obligation consists of the license and research development services and the other two performance obligations are material rights as it relates to potential future targets that have not yet been identified. As described above, the transaction price of $57.5 million was allocated to the performance obligations based on their relative standalone selling prices (Note 6). The Company did not believe that any variable consideration should be included in the transaction price at the date of adoption of ASC 606 on January 1, 2018. Such assessment considered the application of the constraint to ensure that estimates of variable consideration would be included in the transaction price only to the extent the Company had a high degree of confidence that revenue would not be reversed in a subsequent reporting period. The Company re-evaluated On October 5, 2018, the Company entered into the license agreement with Precigen (Note 7). As between the Company and Precigen, the terms of the License Agreement replace the terms of: (a) the Channel Agreement previously entered into with Intrexon Corporation, of the Channel Agreement, including all amendments to the Channel Agreement; (b) certain rights and obligations pursuant to the Ares Trading Agreement; (c) the MD Anderson License (Note 7); and (d) the 2015 Agreement and any amendments or statements of work thereto. In partial consideration of the Company entering into the License Agreement, Precigen is required to use diligent good faith efforts to transfer the Company’s rights and obligations under the Ares Trading Agreement to Intrexon (or its affiliate). As a result, the Company has very limited remaining obligations under the Ares Trading Agreement, and following the Company’s entry into the License Agreement, will not be recognizing any additional revenue under the Ares Trading Agreement .

Commitments and Contingencies

Commitments and Contingencies	9 Months Ended
	Sep. 30, 2019
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	7. Commitments and Contingencies License Agreements Exclusive License Agreement with Precigen, Inc. On October 5, 2018, the Company entered into the License Agreement, with Precigen. As between the Company and Precigen, the terms of the License Agreement replace and supersede the terms of: (a) that certain Exclusive Channel Partner Agreement by and between the Company and Intrexon, dated January 6, 2011, as amended by the First Amendment to Exclusive Channel Partner Agreement effective September 13, 2011, the Second Amendment to the Exclusive Channel Partner Agreement effective March 27, 2015, and the Third Amendment to Exclusive Channel Partner Agreement effective June 29, 2016, which was subsequently assigned by Intrexon to Precigen; (b) certain rights and obligations pursuant to that certain License and Collaboration Agreement effective March 27, 2015 between the Company, Intrexon and Areas Trading S.A., or Ares Trading, a subsidiary of Merck KGaA, or Merck, as assigned by Intrexon to Precigen, or the Ares Trading Agreement; (c) that certain License Agreement between the Company, Intrexon, and MD Anderson, with an effective date of January 13, 2015, or the MD Anderson License, which was subsequently assigned by Intrexon and assumed by Precigen effective as of January 1, 2018; and (d) th e Pursuant to the terms of the License Agreement, Precigen has granted the Company an exclusive, worldwide, royalty-bearing, sub-licensable ® IL-12 sub-licensable Sleeping Beauty The Company will be solely responsible for all aspects of the research, development and commercialization of the exclusively licensed products for the treatment of cancer. The Company is required to use commercially reasonable efforts to develop and commercialize IL-12 two-year Precigen has also granted the Company an exclusive, worldwide, royalty-bearing, sub-licensable IL-12 IL-12 In consideration of the licenses and other rights granted by Precigen, the Company will pay Precigen an annual license fee of $0.1 million and has agreed to reimburse Precigen for certain historical costs of the licensed programs up to $1.0 million, payable quarterly. The Company will make milestone payments totaling up to an additional $52.5 million for each exclusively licensed program upon the initiation of later stage clinical trials and upon the approval of exclusively licensed products in various jurisdictions. In addition, the Company will pay Precigen tiered royalties ranging from low-single IL-12 low-single mid-single The Company is responsible for all development costs associated with each of the licensed products, other than Gorilla IL-12 IL-12 Precigen will pay the Company royalties ranging from low-single mid-single There have been no royalties from net sales under the License Agreement for the three and nine months ended September 30, 2019. In consideration of entering into the License Agreement, Intrexon has forfeited and returned to the Company all shares of Series 1 preferred stock held by or payable to Intrexon as of the date of the License Agreement (Note 9 License Agreement—The University of Texas MD Anderson Cancer Center On January 13, 2015, the Company, together with Intrexon, entered into the MD Anderson License with MD Anderson (which Intrexon subsequently assigned to Precigen). Pursuant to the MD Anderson License, the Company, together with Precigen, holds an exclusive, worldwide license to certain technologies owned and licensed by MD Anderson including technologies relating to novel CAR T-cell non-viral On August 17, 2015, the Company, Precigen and MD Anderson entered into the 2015 Pursuant to the 2015 2015 per year. On October 22, 2019, the Company entered into the Fifth Amendment, which extended the term of the 2015 Agreement until December 31, 2026 and amended the terms of the 2015 Agreement to allow cash resources on hand at MD Anderson under the 2015 Agreement to now be used for development costs under the 2019 Agreement. During the nine months ended September 30, 2019 and 2018, the Company expensed approximately expenses expenses non-current The term of the MD Anderson License expires on the last to occur of (a) the expiration of all patents licensed thereunder, or (b) the twentieth anniversary of the date of the MD Anderson License; provided, however, that following the expiration of the term of the MD Anderson License, the Company, together with Precigen, shall then have a fully-paid up, royalty free, perpetual, irrevocable and sublicensable license to use the licensed intellectual property thereunder. After ten years from the date of the MD Anderson License and subject to a 90-day non-exclusive case-by-case 180-day License Agreement with the National Cancer Institute On May 28, 2019, the Company entered into a patent license agreement, or the Patent License, with the National Cancer Institute, or the NCI. Pursuant to the Patent License, the Company holds an exclusive, worldwide license to certain intellectual property to develop and commercialize patient-derived (autologous), peripheral blood T-cell T-cell non-viral non-exclusive, Pursuant to the terms of the Patent License, the Company is required to pay the NCI a cash payment in the aggregate amount of $1.5 million payable in $0.5 million installments within sixty days, six-months, and the for the Patent License approximately $46 thousand. During the three and nine months ended September 30, 2019, the Company made payments under the Patent License for $0.5 million. At September 30, 2019, the Company included the remaining $1.0 million for the Patent License as current liabilities on the Company’s balance sheet. The terms of the Patent License also require the Company to pay the NCI minimum annual royalties in the amount of $0.3 million, which amount will be reduced to $0.1 million once the aggregate minimum annual royalties paid by the Company equals $1.5 million. The first minimum annual royalty payment is payable on the date that is eighteen months following the date of the Patent License. The Company is also required to make performance-based payments upon successful completion of clinical and regulatory benchmarks relating to the licensed products. The aggregate potential benchmark payments are $4.3 million, of which aggregate payments of $3.0 million are due only after marketing approval in the United States or in Europe, Japan, Australia, China or India. The first benchmark payment of $0.1 million will be due upon the initiation of the Company’s first sponsored phase 1 clinical trial of a licensed product or licensed process in the field of use licensed under the Patent License. In addition, the Company is required to pay the NCI one-time mid-single The Patent License will expire upon expiration of the last patent contained in the licensed patent rights, unless terminated earlier. The NCI may terminate or modify the Patent License in the event of a material breach, including if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event. The Company may terminate the Patent License, or any portion thereof, in the Company’s sole discretion at any time upon 60 days’ written notice to the NCI. In addition, the NCI has the right to: (i) require the Company to sublicense the rights to the product candidates covered by the Patent License upon certain conditions, including if the Company is not reasonably satisfying required health and safety needs and (ii) terminate or modify the Patent License, including if the Company is not satisfying requirements for public use as specified by federal regulations. Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute On January 10, 2017, the Company announced the signing of a Cooperative Research and Development Agreement, or CRADA, with the NCI for the development of adoptive cell transfer, or ACT,-based immunotherapies genetically modified using the Sleeping Beauty non-viral Sleeping Beauty In February 2019, the Company extended the CRADA with the NCI for two years, committing an additional $5.0 million to this program through January 2022. The remaining obligation, as of September 30, 2019, to the NCI under the CRADA is $5.6 million over the next two years, payable in $0.6 million payments on a quarterly basis. The Company made payments of $0.6 million and $1.9 million, during the three and nine months ended September 30, 2019 and 2018, respectively. Exclusive Channel Partner Agreement with Precigen for the Cancer Programs From 2011 to 2018, the Company was party to various arrangements with Intrexon (now Precigen) in which the Company used Precigen’s technology to research and develop cancer treatments in return for various future profit sharing and royalty arrangements. These agreements were modified or terminated by the License Agreement described in Note 9. Ares Trading License and Collaboration Agreement On March 27, 2015, the Company, together with Intrexon (now Precigen), signed the Ares Trading Agreement, with Ares Trading, through which the parties established a collaboration for the research and development and commercialization of certain products for the prophylactic, therapeutic, palliative or diagnostic use for cancer in humans. Precigen was entitled to receive $ 5.0 2018 Ares Trading paid a non-refundable Under the License Agreement, Precigen agreed to perform all future obligations of the Company under the Ares Trading Agreement other than certain payment obligations. Accordingly, the Company recognized the remaining deferred revenue as part of the settlement of a related party relationship as described in Note 9 Patent and Technology License Agreement—The University of Texas MD Anderson Cancer Center and the Texas A&M University System On August 24, 2004, the Company entered into a patent and technology license agreement with MD Anderson and the Texas A&M University System, which the Company refers to, collectively, as the Licensors. Under this agreement, the Company was granted an exclusive, worldwide license to rights (including rights to U.S. and foreign patent and patent applications and related improvements and know-how) Under the terms of the agreement, the Company may be required to make additional payments to the Licensors upon achievement of certain other milestones in varying amounts which, on a cumulative basis could total up to an additional $4.5 million. In addition, the Licensors are entitled to receive single digit percentage royalty payments on sales from a licensed product and will also be entitled to receive a portion of any fees that the Company may receive from a possible sublicense under certain circumstances. Collaboration Agreement with Solasia Pharma K.K. On March 7, 2011, the Company entered into a License and Collaboration Agreement with Solasia which was amended on July 31, 2014 to include an exclusive worldwide license. Pursuant to the License and Collaboration Agreement, the Company granted Solasia an exclusive license to develop and commercialize darinaparsin in both intravenous and oral forms and related organic arsenic molecules, in all indications for human use As consideration for the license, the Company is eligible to receive from Solasia development- and sales-based milestones, a royalty on net sales of darinaparsin, once commercialized, and a percentage of any sublicense revenues generated by Solasia. Solasia will be responsible for all costs related to the development, manufacturing and commercialization of darinaparsin. The Company’s Licensors, as defined in the agreement, will receive a portion of all milestone and royalty payments made by Solasia to the Company in accordance with the terms of the license agreement with the Licensors.

Related Party Transactions

Related Party Transactions	9 Months Ended
	Sep. 30, 2019
Related Party Transactions [Abstract]
Related Party Transactions	8. Related Party Transactions Collaborations with Intrexon/ Precigen During the three and nine months ended September 30, 2018, the Company issued an aggregate of 3,847 and 11,205 shares of Series 1 preferred stock to Intrexon, the holder of all of the outstanding shares of the Company’s Series 1 preferred stock, as monthly dividend payments, respectively. At September 30, 2018, the Company recorded such shares of Series 1 preferred stock at a fair value of $6.1 million which is a component of temporary equity. During the nine months ended September 30, 2018, the Company recorded a gain on the change of the derivative liabilities in the amount of $0.2 million (Note 12) During the nine months ended September 30, 2019 and 2018, the Company expensed $1.7 million and $6.7 million, respectively, for services performed by Precigen. As of September 30, 2019 and December 31, 2018, the Company recorded $0.8 million and $1.9 million, respectively, in current liabilities on its balance sheet for amounts due to Precigen. On October 5, 2018, the Company entered into the License Agreement, the terms of which replaced the terms of the Channel Agreement (Note 9) . Collaboration with Precigen and MD Anderson On January 13, 2015, the Company, together with Intrexon, entered into the MD Anderson License with MD Anderson (which Intrexon subsequently assigned to Precigen). Pursuant to the MD Anderson License, the Company, together with Precigen, hold an exclusive, worldwide license to certain technologies owned and licensed by MD Anderson including technologies relating to novel CAR T cell therapies, non-viral The Company has determined that the rights acquired in the MD Anderson License represent in-process which is classified under prepaid expenses and other current assets at September 30, 2019. The classification is based on management’s current estimate of plans to utilize the prepaid expense balance and is subject to revision on a quarterly basis.

Settlement of a Related Party R

Settlement of a Related Party Relationship	9 Months Ended
	Sep. 30, 2019
Related Party Transactions [Abstract]
Settlement of relatedparty relationship	9. Settlement of a Related Party Relationship Exclusive License Agreement with Precigen On October 5, 2018, the Company entered into the license agreement with Precigen. As between the Company and Precigen, the terms of the License Agreement replace the terms of: (a) the Channel Agreement, including all amendments to the Channel Agreement; (b) certain rights and obligations pursuant to the Ares Trading Agreement; (c) the MD Anderson License; and (d) the 2015 Pursuant to the terms of the License Agreement, Precigen has granted the Company an exclusive, worldwide, royalty-bearing, sub-licensable ® IL-12 sub-licensable Sleeping Beauty The Company is solely responsible for all aspects of the research, development and commercialization of the exclusively licensed products for the treatment of cancer. The Company is required to use commercially reasonable efforts to develop and commercialize IL-12 two-year sub-licensable IL-12 Research and Development The agreement also calls for an annual license fee of $0.1 million as long as the agreement is effective. The Company will also make milestone payments totaling up to an additional $52.5 million for each exclusively licensed program upon the initiation of later stage clinical trials and upon the approval of exclusively licensed products in various jurisdictions. In addition, the Company will pay Precigen tiered royalties ranging from low-single IL-12 low-single mid-single The Company is responsible for all development costs associated with each of the licensed products, other than Gorilla IL-12 IL-12 Precigen will pay the Company royalties ranging from low-single mid-single In consideration of the Company entering into the License Agreement, Intrexon forfeited and returned to the Company all shares of the Company’s Series 1 preferred stock held by or payable to Intrexon as of the date of the License Agreement. In addition, Precigen is required to transfer all of Ziopharm’s rights and obligations under the Ares Trading Agreement to Intrexon (or its affiliate). See Note 7 The Company determined that this transaction represented a capital transaction between related parties. The Company calculated the fair value of the preferred stock and the derivative liability on the date of the transaction, noting a total fair value of $163.3 million. The relinquishment of the Company’s obligation under the Ares Trading Agreement was also considered part of the overall capital transaction. The Company recognized an additional credit to accumulated deficit of $49.5 million as a result of the relief of the obligation under the Ares Trading Agreement (Note 7 The Company incurred approximately $7.4 million of transaction advisory costs with third-party vendors, of which $5.4 million was considered a direct cost associated with the Series 1 preferred stock extinguishment and is also included as part of the consideration transferred. The remaining $2.0 million of transaction costs were recognized as an expense during the year ended December 31, 2018. The Company recognized a net credit to accumulated deficit of $207.3 million, calculated as the difference in the carrying value of the Series 1 preferred stock, derivative liability, and contract liability, and the consideration transferred of $5.4 million, in connection with the transaction. This amount is included in net income available to common shareholders in the calculation of earnings per share (Note 5

Leases

Leases	9 Months Ended
	Sep. 30, 2019
Leases, Operating [Abstract]
Leases	10. Leases The Company adopted Topic 842 on January 1, 2019 using the effective date method, in which it did not restate prior periods. Upon adoption, the Company elected the package of practical expedients permitted under the transition guidance within Topic 842 which, among other things, allowed it to carry forward the historical lease classification. The Company does not allocate consideration in its leases to lease and non-lease The Company uses its estimated incremental borrowing rate, which is derived from information available at the lease commencement date, in determining the present value of lease payments. The Company’s incremental borrowing rate represents the rate of interest that it would have to pay to borrow over a similar term an amount equal to the lease payments in a similar economic environment. The Company considers publicly available data for instruments with similar terms and characteristics when determining its incremental borrowing rates. The adoption of Topic 842 resulted in recognition of approximately $1.6 million of right-of-use right-of-use In June 2012, the Company entered into a master lease for the Company’s corporate headquarters in Boston office, which was originally set to expire in August 2016, but renewed through August 31, 2021 On January 30, 2018, the Company entered into a lease agreement for office space in Houston at MD Anderson. Under the terms of the Houston lease agreement, the Company leases approximately two hundred and ten square feet and are required to make rental payments at an average monthly rate of approximately $1 thousand through April 2021. All future rent expense incurred in Houston, will be deducted from the Company’s prepayments at MD Anderson. On March 12, 2019, the Company entered into a lease agreement for office space in Houston. Under the terms of the Houston lease agreement, the Company leases approximately one thousand and thirty-eight square feet and is required to make rental payments at an average monthly rate of approximately $2 thousand through April 2021. The components of lease expense were as follows: (in thousands) Three Months Ended Nine Months Ended Operating lease cost $ 184 $ 585 Total lease cost $ 184 $ 585 Weighted-average remaining lease term (years) 2. 15 2.15 Weighted-average discount rate 8.00 % 8.00 % Cash paid for amounts included in the measurement of the lease liabilities were $0.5 million for the nine months ended September 30, 2019. As of September 30, 2019, the maturities of the Company’s operating lease liabilities were as follows (in thousands): Maturity of Lease Liabilities Operating Leases 2019(excluding the nine months ended September 30, 2019) $ 188 2020 755 2021 491 Total lease payments $ 1,434 Less: Imputed Interest and Adjustments 110 Present value of lease payments $ 1,324 Disclosures related to periods prior to adoption of the New Lease Standard Prior to the adoption of ASC 842, the Company recorded rent expense on a straight-line basis over the term of the lease under ASC 840. Total rent expense for the three and nine months ended September 30, 2018 was approximately $0.1 million and $0.5 million, respectively. For comparative purposes, the Company’s aggregate future minimum non-cancellable 2019 723 2020 736 2021 488 Future minimum lease payments, net $ 1,947

Stock-Based Compensation

Stock-Based Compensation	9 Months Ended
	Sep. 30, 2019
Text Block [Abstract]
Stock-Based Compensation	11. Stock-Based Compensation The Company recognized stock-based compensation expense on all employee and non-employee For the three months ended For the nine months ended (in thousands) 2019 2018 2019 2018 Research and development $ 339 $ 552 $ 1,068 $ 1,765 General and administrative 1,147 928 3,673 5,085 Stock-based compensation expense $ 1,486 $ 1,480 $ 4,741 $ 6,850 The Company granted an aggregate of 140,000 and 1,835,755 stock options during the three and nine months ended September 30, 2019 with a weighted-average grant date fair value of $3.05 and $1.90 per share, respectively. The Company granted an aggregate of 300,500 and 506,000 stock options during the three and nine months ended September 30, 2018 with a weighted average grant date fair value of $2.11 and $2.49 per share, respectively. On January 6, 2019, the Company paid an accrued annual performance bonus by issuing 446,428 shares of common stock. On June 13, 2019 the Company extended the contractual life of 52,500 fully vested stock options held by a director of the Company. Additionally, on June 13, 2019, the Company accelerated the vesting and extended the contractual life of 126,700 stock options held by a director. These extensions and acceleration of vesting resulted in additional stock compensation expense of $0 and $0.4 million in the three and nine months ended September 30, 2019. On February 15, 2018, the Company extended the contractual life of 751,667 fully vested stock options held by an officer of the Company by an additional nine months. Additionally, on March 12, 2018, the Company extended the contractual life of 117,500 fully vested stock options held by a director. These extensions did not result in additional stock compensation expense for the three months ended September 30, 2018. Additional stock compensation expense of $0.5 million was recorded for the nine months ended September 30, 2018. For the three months ended September 30, 2019 and 2018, the fair value of stock options was estimated on the date of grant using a Black-Scholes option valuation model with the following assumptions: For the three months ended 2019 2018 Risk-free interest rate 1.39 - 1.92% 2.82 - 2.98% Expected life in years 6.25 6 Expected volatility 72.87 - 78.34% 82.27 - 83.08% Expected dividend yield 0 0 Stock option activity under the Company’s stock option plan for the nine months ended September 30, 2019 is as follows: (in thousands, except share and per share data) Number of Weighted- Exercise Price Weighted- Average Term (Years) Aggregate Outstanding, December 31, 2018 5,277,085 $ 4.24 Granted 1,835,755 2.69 Exercised (482,500 ) 3.48 Cancelled (1,634,791 ) 4.11 Outstanding, September 30, 2019 4,995,549 $ 3.78 7.84 $ 6,025 Options exercisable, September 30, 2019 2,581,327 $ 4.59 6.60 $ 2,425 Options exercisable, December 31, 2018 3,099,935 $ 5.15 4.93 $ 88 Options available for future grant 3,971,940 At September 30, 2019, total unrecognized compensation costs related to unvested stock options outstanding amounted to $6.7 million. The cost is expected to be recognized over a weighted-average period of 1.78 years. A summary of the status of unvested restricted stock for the nine months ended September 30, 2019 is as follows: Number of Shares Weighted-Average Non-vested, 682,070 $ 3.47 Granted 1,408,536 2.26 Vested (446,428 ) 2.24 Cancelled (74,599 ) 3.41 Non-vested, Se ptember 1,569,579 $ 2.91 At September 30, 2019, total unrecognized compensation costs related to unvested restricted stock outstanding amounted to $2.8 million. The cost is expected to be recognized over a weighted-average period of 1.48 years.

Preferred Stock

Preferred Stock	9 Months Ended
	Sep. 30, 2019
Equity [Abstract]
Preferred Stock	12. Preferred Stock The Company’s Board of Directors is authorized to designate any series of Preferred Stock, to fix and determine the variations in relative rights, preferences, privileges and restrictions as between and among such series. On June 29, 2016, the Company entered into the 2016 ECP Amendment and Amendment to Exclusive Channel Collaboration Agreement, or the 2016 GvHD Amendment, with Intrexon (now Precigen) (Note 7 On October 5, 2018, the Company and Precigen entered into the License Agreement to replace all existing agreements between the companies, which provides the Company with certain exclusive and non-exclusive 7 8 12

Derivative Financial Instrument

Derivative Financial Instruments	9 Months Ended
	Sep. 30, 2019
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Derivative Financial Instruments	13. Derivative Financial Instruments The Company determined that certain embedded features related to the Series 1 preferred stock were derivative financial instruments. The company values the embedded derivative financial instruments related to the Series 1 preferred stock as Level 3 financial liabilities (Note 4 On October 5, 2018, the Company entered into the License Agreement with Precigen. In partial consideration for the termination of the former agreements, the Company and Precigen agreed that Intrexon would forfeit all outstanding shares of the Series 1 preferred stock held by Intrexon, including any accrued dividends and related financial instruments. Thus, upon closing of the transaction, these derivative financial instruments were no longer outstanding (Note 9

Warrants

Warrants	9 Months Ended
	Sep. 30, 2019
Warrants Disclosure [Abstract]
Warrant	14. Warrants In connection with the Company’s November 2018 private placement which provided net proceeds of approximately $47.1 million, the Company issued warrants to purchase an aggregate of 18,939,394 shares of common stock which became exercisable six five The Company assessed whether the warrants require accounting as derivatives. The Company determined that the warrants were (1) indexed to the Company’s own stock and (2) classified in stockholders’ equity in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) Topic 815, Derivatives and Hedging On July 26, 2019 and September 12, 2019, the Company entered into agreements with existing investors for the exercise of previously issued warrants to purchase common stock in a private placement. Pursuant to the terms of the agreements, investors exercised their 2018 warrants for an aggregate of 17,803,031 shares of common stock, at an exercise price of $3.01 per share. The warrants exercised were originally issued by the Company in a private placement that closed in November 2018 (Note 2). Proceeds from the warrant exercise, after deducting placement agent fees and other related expenses of $1.1 million were approximately $52.5 million. The Company issued the participating investors new warrants to purchase up to 17,803,031 additional shares of common stock as an inducement for the warrant holders to exercise their 2018 warrants early. The 2019 warrants will become exercisable six months following the date of issuance, will expire on the fifth anniversary of the initial exercise date, and have an exercise price of $7.00. The 2019 warrants were valued using a Black-Scholes valuation model and resulted in a $60.8 million non-cash charge to the Company’s statement of operations for the three and nine months ended September 30, 2019. The Company assessed whether the 2019 warrants require accounting as derivatives. The Company determined that the warrants were (1) indexed to the Company’s own stock and (2) classified in stockholders’ equity in accordance with FASB ASC Topic 815, Derivatives and Hedging

Joint Venture

Joint Venture	9 Months Ended
	Sep. 30, 2019
Equity Method Investments and Joint Ventures [Abstract]
Joint Venture	15. Joint Venture On December 18, 2018, the Company entered into a Framework Agreement with TriArm Therapeutics, Ltd., or TriArm, whereby the parties will launch Eden BioCell, Ltd., or Eden BioCell, to lead clinical development and commercialization of certain Sleeping Beauty-generated CAR-T therapies as set forth in a separate license agreement. On January 3, 2019, Eden BioCell was incorporated in Hong Kong as a private company. Eden BioCell, the Company and TriArm entered into a Share Subscription Agreement on January 23, 2019, where the Company and TriArm agreed to contribute certain intellectual property, services and cash (only with respect to TriArm) to Eden BioCell to subscribe for a certain number of newly issued ordinary shares in the share capital of Eden BioCell. On the closing date, upon the issuance and subscription of the shares, in respect of the aforementioned consideration, 10,000,000 ordinary shares were issued to the Company and 10,000,000 ordinary shares were issued to TriArm. The closing of the transaction occurred on July 5, 2019. The Framework Agreement and Share Subscription Agreements were each respectively amended to be effective as of this date. Upon consummation of the joint venture, Eden BioCell and the Company also entered into a license agreement, pursuant to which the Company licensed the rights to Eden BioCell for third-generation Sleeping Beauty As of July 5, 2019, as a result of the design and purpose of Eden BioCell, the Company determined that Eden BioCell was considered a varia ble interest , or VIE, The Company determined that Eden BioCell was not a customer and therefore, accounted for the transaction as the transfer of nonfinancial assets to be recognized at their fair value on the contribution date. The fair value of the intellectual property contributed to Eden BioCell had a de minimis value due to the early stage of the technology and the likelihood of clinical success. Due to the intellectual property contributed , the Company did not record a gain or loss on this transaction and recognized a value of $0 for their equity-method investment.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	9 Months Ended
	Sep. 30, 2019
Accounting Policies [Abstract]
Leases	Leases In February 2016, the FASB issued ASU 2016-02, right-of-use The standard permits two transition methods, (1) to apply the new lease requirements at the beginning of the earliest period presented, or (2) to apply the new lease requirements at the effective date. The Company adopted Topic 842 as of January 1, 2019 using the effective date method, in which it did not restate prior periods. Upon adoption, the Company elected the package of practical expedients permitted under the transition guidance within Topic 842 which, among other things, allowed it to carry forward the historical lease classification. The adoption of Topic 842 on January 1, 2019 resulted in recognition of approximately $1.6 million of right-of-use
New Accounting Pronouncements	New Accounting Pronouncements In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement 2018-03. In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting 2018-07.
Variable Interest Entities	Variable Interest Entities The Company reviews each legal entity formed by parties related to the Company to determine whether or not the entity is a Variable Interest Entity, or VIE. If the entity is a VIE, the Company assesses whether or not it is the primary beneficiary of that VIE based on a number of factors, including (i) which party has the power to direct the activities of the VIE that most significantly affect its economic performance, (ii) the parties’ contractual rights and responsibilities pursuant to any contractual agreements and (iii) which party has the obligation to absorb losses or the right to receive benefits from the VIE. If the Company determines that it is the primary beneficiary of a VIE, it consolidates the financial statements of the VIE into its consolidated financial statements at the time that determination is made. The Company evaluates whether it continues to be the primary beneficiary of any consolidated VIEs on a quarterly basis. If the Company determines that it is no longer the primary beneficiary of a consolidated VIE, or no longer has a variable interest in the VIE, the Company deconsolidates the VIE in the period that the determination is made .

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	9 Months Ended
	Sep. 30, 2019
Fair Value Disclosures [Abstract]
Assets and Liabilities Measured at Fair Value on Recurring Basis	Assets and liabilities measured at fair value on a recurring basis as of September 30, 2019 and December 31, 2018 were as follows: ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 73,198 $ 73,198 $ — $ — ($ in thousands) Fair Value Measurements at Reporting Date Using Description Balance as of Quoted Prices in Significant Other Significant Assets: Cash equivalents $ 24,437 $ 24,437 $ — $ —

Net Loss per Share (Tables)

Net Loss per Share (Tables)	9 Months Ended
	Sep. 30, 2019
Earnings Per Share [Abstract]
Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share	Such potentially dilutive shares of common stock at September 30, 2019 and 2018 consisted of the following: September 30, 2019 2018 Stock options 4,995,549 4,569,468 Inducement stock options 965,000 — Unvested restricted stock 1,569,579 1,164,352 Warrants 18,939,394 — Preferred stock — 52,583,921 26,469,522 58,317,741

Leases (Tables)

Leases (Tables)	9 Months Ended
	Sep. 30, 2019
Leases, Operating [Abstract]
Components of Lease Expense	The components of lease expense were as follows: (in thousands) Three Months Ended Nine Months Ended Operating lease cost $ 184 $ 585 Total lease cost $ 184 $ 585 Weighted-average remaining lease term (years) 2. 15 2.15 Weighted-average discount rate 8.00 % 8.00 %
Lessee, Operating Lease, Liability, Maturity	As of September 30, 2019, the maturities of the Company’s operating lease liabilities were as follows (in thousands): Maturity of Lease Liabilities Operating Leases 2019 (excluding the nine months ended September 30, 2019) $ 188 2020 755 2021 491 Total lease payments $ 1,434 Less: Imputed Interest and Adjustments 110 Present value of lease payments $ 1,324
Future Net Minimum Lease Payments under Operating Leases	For comparative purposes, the Company’s aggregate future minimum non-cancellable 2019 723 2020 736 2021 488 Future minimum lease payments, net $ 1,947

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	9 Months Ended
	Sep. 30, 2019
Text Block [Abstract]
Stock-Based Compensation Expense on All Employee and Non-Employee Awards	The Company recognized stock-based compensation expense on all employee and non-employee For the three months ended September 30, For the nine months ended September 30, (in thousands) 2019 2018 2019 2018 Research and development $ 339 $ 552 $ 1,068 $ 1,765 General and administrative 1,147 928 3,673 5,085 Stock-based compensation expense $ 1,486 $ 1,480 $ 4,741 $ 6,850
Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model	For the three months ended September 30, 2019 and 2018, the fair value of stock options was estimated on the date of grant using a Black-Scholes option valuation model with the following assumptions: For the three months ended September 30, 2019 2018 Risk-free interest rate 1.39 - 1.92% 2.82 - 2.98% Expected life in years 6.25 6 Expected volatility 72.87 - 78.34% 82.27 - 83.08% Expected dividend yield 0 0
Stock Option Activity under Stock Option Plan	Stock option activity under the Company’s stock option plan for the nine months ended September 30, 2019 is as follows: (in thousands, except share and per share data) Number of Weighted- Exercise Price Weighted- Average Term (Years) Aggregate Outstanding, December 31, 2018 5,277,085 $ 4.24 Granted 1,835,755 2.69 Exercised (482,500 ) 3.48 Cancelled (1,634,791 ) 4.11 Outstanding, September 30, 2019 4,995,549 $ 3.78 7.84 $ 6,025 Options exercisable, September 30, 2019 2,581,327 $ 4.59 6.60 $ 2,425 Options exercisable, December 31, 2018 3,099,935 $ 5.15 4.93 $ 88 Options available for future grant 3,971,940
Summary of Unvested Restricted Stock	A summary of the status of unvested restricted stock for the nine months ended September 30, 2019 is as follows: Number of Shares Weighted-Average Non-vested, 682,070 $ 3.47 Granted 1,408,536 2.26 Vested (446,428 ) 2.24 Cancelled (74,599 ) 3.41 Non-vested, Se ptember 1,569,579 $ 2.91

Business - Additional Informati

Business - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Oct. 22, 2019	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Cash and cash equivalents		$ 88,419		$ 88,419		$ 61,729
Accumulated deficit		(668,379)		(668,379)		$ (566,329)
Research and development expense		$ 8,641	$ 8,263	$ 28,115	$ 25,935
Subsequent Event [Member] | Two Thousand Nineteen Agreement [Member]
Number of shares issued for warrants	3,333,333
Exercise price of warrants	$ 0.001
License agreement termination date	Dec. 31, 2026
Warrants expire date	Dec. 31, 2026
Subsequent Event [Member] | MD Anderson License and the Research and Development Agreement Member [Member] | Two Thousand Nineteen Agreement [Member]
Research and development expense	$ 20,000
Subsequent Event [Member] | MD Anderson License and the Research and Development Agreement Member [Member] | Two Thousand Nineteen Agreement [Member] | Performance Based Payments Member [Member]
Aggregate Benchmark Payments Payable	36,500
Subsequent Event [Member] | MD Anderson License and the Research and Development Agreement Member [Member] | Two Thousand Nineteen Agreement [Member] | Performance Based Payments Member [Member] | Post Marketing Approval [Member]
Aggregate Benchmark Payments Payable	$ 3,000

Financings - Additional Informa

Financings - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	Sep. 12, 2019	Nov. 11, 2018	Sep. 30, 2019	Sep. 30, 2019	Dec. 31, 2018
Class of Stock [Line Items]
Common stock, par value			$ 0.001	$ 0.001	$ 0.001
Gross proceeds received			$ 2,971	$ 2,971
Proceeds from private placement	$ 52,500
At The Market Offering [Member]
Class of Stock [Line Items]
Stock issued during period			639,442	639,442
Sale of stock consideration received on transaction			$ 3,000	$ 3,000
Private Placement [Member]
Class of Stock [Line Items]
Class of warrant or right, number of securities called by warrants or rights	17,803,031		18,939,394	18,939,394
Warrant Exercise Price per share	$ 3.01		$ 3.01	$ 3.01
Placement agent fees and other expenses	$ 1,100
Private Placement [Member] | New Warrants [Member]
Class of Stock [Line Items]
Class of warrant or right, number of securities called by warrants or rights	17,803,031
Warrant Exercise Price per share	$ 7
Securities Purchase Agreement [Member]
Class of Stock [Line Items]
Stock issued during period		18,939,394
Common stock, par value		$ 0.001
par value per share		$ 2.64
Gross proceeds received		$ 47,100		$ 47,100

Summary of Significant Accoun_3

Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands	Sep. 30, 2019USD ($)
Summary Of Significant Accounting Policies [Line Items]
Total operating lease liabilities	$ 1,324
Operating Lease, Right-of-Use Asset	$ 1,283
Lessee, Operating Lease, Term of Contract	12 months
ASU 2016-02
Summary Of Significant Accounting Policies [Line Items]
Total operating lease liabilities	$ 1,600
Operating Lease, Right-of-Use Asset	$ 1,600

Assets and Liabilities Measured

Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 73,198	$ 24,437
Quoted Prices in Active Markets for Identical Assets/Liabilities (Level 1)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 73,198	$ 24,437

Potential Dilutive Shares Exclu

Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail) - shares	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	26,469,522	58,317,741
Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	18,939,394
Stock Options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	4,995,549	4,569,468
Stock Options | Two Thousand Twelve Stock Option Plan [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	965,000
Unvested Restricted Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount	1,569,579	1,164,352
Series 1 Preferred Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount		52,583,921

Revenue Recognition - Additiona

Revenue Recognition - Additional Information (Detail) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018	Jan. 01, 2018	May 31, 2015
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Accumulated deficit	$ (668,379)		$ (566,329)
Collaboration revenue		$ 146
Difference between Revenue Guidance in Effect before and after Topic 606
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Accumulated deficit				$ 8,100
ARES Trading License
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Deferred revenue, upfront payment					$ 57,500
ARES Trading License | Difference between Revenue Guidance in Effect before and after Topic 606
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	0
License Agreement With Precigen
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenue	$ 0

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) $ in Thousands

May 28, 2019USD ($)

Oct. 05, 2018USD ($)

Jan. 13, 2015USD ($)

Aug. 24, 2004USD ($)Patent

Jul. 31, 2015USD ($)

Sep. 30, 2019USD ($)

Sep. 30, 2018USD ($)

Sep. 30, 2019USD ($)

Sep. 30, 2018USD ($)

Dec. 31, 2018USD ($)

Dec. 31, 2017

Nov. 28, 2020USD ($)

Feb. 19, 2019USD ($)

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 8,641

$ 8,263

$ 28,115

$ 25,935

Research and development arrangement Terms

Pursuant to the Research and Development Agreement, the Company, Precigen and MD Anderson formed a joint steering committee to oversee and manage the new and ongoing research programs. Under the License Agreement with Precigen, the Company and Precigen agreed that Precigen would no longer participate on the joint steering committee after the date of the License Agreement. As provided under the MD Anderson License, the Company provided funding for research and development activities in support of the research programs under the Research and Development Agreement for a period of three years and in an amount of no less than $15.0 million and no greater than $20.0 million per year.

Cash balance

88,419

88,419

$ 61,729

Agreement commencement date

2015-05

Number of products | Patent

2

MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Research and development service agreement aggregate quarterly payments

4,700

4,000

Cash resources on hand

21,500

21,500

27,800

CRADA Agreement [Member]

Commitments and Contingencies Disclosure [Line Items]

Obligations due under contract

$ 5,000

Remaining contractual obligation

$ 5,600

Quarterly payments under contract

600

600

1,900

1,900

Gorilla IL12 Products [Member] | Parent [Member]

Commitments and Contingencies Disclosure [Line Items]

Percentage of development costs

80.00%

Percentage of operating profits

80.00%

CAR Products [Member]

Commitments and Contingencies Disclosure [Line Items]

Royalty income

0

0

Amount of royalties receivable

$ 50,000

License Agreement with the National Cancer Institute [Member]

Commitments and Contingencies Disclosure [Line Items]

Expected cash payment payable per installments

$ 500

The University of Texas MD Anderson Cancer Center and The Texas A & M University System

Commitments and Contingencies Disclosure [Line Items]

Milestone maximum payment

$ 4,500

ARES Trading License

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 36

$ 36

License Agreement with the National Cancer Institute [Member]

Commitments and Contingencies Disclosure [Line Items]

Reimbursement of historical costs

46

Expected Cash Payment Payable

1,500

1,000

1,000

Minimum Royalties Amount Payable

$ 300

Description Of First Annual Royalty Payable

The first minimum annual royalty payment is payable on the date that is eighteen months following the date of the Patent License

Description Of First Benchmark Payable

The first benchmark payment of $0.1 million will be due upon the initiation of the Company’s first sponsored phase 1 clinical trial of a licensed product or licensed process in the field of use licensed under the Patent License.

Description Of option To terminate Agreement

The NCI may terminate or modify the Patent License in the event of a material breach, including if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event

Agreement termination, notice period

60 days

payments under the Patent License

500

500

License Agreement with the National Cancer Institute [Member] | Performance Based Payments Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Aggregate Benchmark Payments Payable

$ 4,300

License Agreement with the National Cancer Institute [Member] | One Time Benchmark Payments [Member]

Commitments and Contingencies Disclosure [Line Items]

Potential Benchmark Payments Payable

12,000

License Agreement with the National Cancer Institute [Member] | Scenario, Forecast [Member]

Commitments and Contingencies Disclosure [Line Items]

Expected Cash Payment Payable

$ 1,500

Minimum Royalties Amount Payable

$ 100

License Agreement with the National Cancer Institute [Member] | Post Marketing Approval [Member] | Performance Based Payments Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Aggregate Benchmark Payments Payable

3,000

License Agreement with the National Cancer Institute [Member] | licensed products [Member] | One Time Benchmark Payments [Member]

Commitments and Contingencies Disclosure [Line Items]

Maximum Sales Revenue On Which Benchmark Payments Payable

$ 1,000,000

Prepaid Expenses and Other Current Assets | MD Anderson License

Commitments and Contingencies Disclosure [Line Items]

Cash balance

18,400

18,400

Other Noncurrent Assets | MD Anderson License

Commitments and Contingencies Disclosure [Line Items]

Cash balance

9,400

9,400

Intrexon Corporation

Commitments and Contingencies Disclosure [Line Items]

Licensing fee

$ 115,000

Research and development expense

$ 1,000

Milestone payment receivable

$ 5,000

$ 5,000

Milestone payment receivable period

2 years

Upfront payment received

$ 57,500

Percentage of upfront fee Payable

50.00%

Annual Licensing fee

100

Reimbursement of historical costs

1,000

Expected additional milestones payable

$ 52,500

Intrexon Corporation | Gorilla IL12 Products [Member]

Commitments and Contingencies Disclosure [Line Items]

Percentage of development costs

20.00%

Percentage of operating profits

20.00%

Intrexon Corporation | T-cell receptor

Commitments and Contingencies Disclosure [Line Items]

Maximum royalty amount

$ 100,000

Portion of income payable to related party

20.00%

Minimum | MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 15,000

Maximum | MD Anderson License and the Research and Development Agreement Member [Member]

Commitments and Contingencies Disclosure [Line Items]

Research and development expense

$ 20,000

Related Party Transactions - Ad

Related Party Transactions - Additional Information (Detail) - USD ($)	Jun. 29, 2016	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018	Dec. 31, 2015
Related Party Transaction [Line Items]
Change in fair value of derivative liability			$ (165,000)		$ 46,000
Amounts expensed for services incurred		$ 13,448,000	12,570,000	$ 41,822,000	41,290,000
Research and development expense		8,641,000	8,263,000	28,115,000	25,935,000
MD Anderson License and the Research and Development Agreement Member [Member]
Related Party Transaction [Line Items]
Research and development service agreement aggregate quarterly payments				4,700,000	4,000,000
Cash resources on hand		21,500,000		21,500,000		$ 27,800,000
Series 1 Preferred Stock
Related Party Transaction [Line Items]
Temporary equity, fair value			$ 6,100,000		6,100,000
Change in fair value of derivative liability					200
License Agreement | M.D. Anderson Cancer Center
Related Party Transaction [Line Items]
Issuance of common stock in licensing agreement (in shares)							11,722,163
Research and development expense							$ 67,300,000
Cooperative Research and Development Agreement | M.D. Anderson Cancer Center
Related Party Transaction [Line Items]
Research and development service agreement aggregate quarterly payments					2,700,000
Research and development service agreement aggregate payments					41,900,000
Intrexon Corporation/Precigen
Related Party Transaction [Line Items]
Amounts expensed for services incurred				1,700,000	$ 6,700,000
Amount due to related party, current		$ 800,000		$ 800,000		1,900,000
Research and development expense						$ 1,000,000
Intrexon Corporation/Precigen | Series 1 Preferred Stock
Related Party Transaction [Line Items]
Issuance of common stock in licensing agreement (in shares)	100,000		3,847		11,205

Settlement of a Related Party_2

Settlement of a Related Party Relationship - Additional Information (Detail) - USD ($) $ in Thousands	Oct. 05, 2018	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Transaction advisory costs recognized as expense						$ 2,000
Research and development expense		$ 8,641	$ 8,263	$ 28,115	$ 25,935
Accrued expenses		$ 9,573		$ 9,573		8,763
Gorilla IL-12 Products
Percentage of development cost shared by other party	80.00%
Percentage of operating profit shared by other party	80.00%
Intrexon Corporation/Precigen
Annual Licensing fee	$ 100
Reimbursement of historical costs	1,000
Preferred stock, contract liability, derivative liability	163,300
Increase in accumulated deficit	49,500
Related party transaction, amounts of transaction	212,800
Research and development expense						$ 1,000
Additional milestone payment for exclusively licensed program to be paid	52,500
Maximum Royalty payable	$ 100,000
Percentage of sublicensing income	20.00%
Royalty payment to be received	$ 50,000
Intrexon Corporation/Precigen | Gorilla IL-12 Products
Percentage of development cost shared by other party	20.00%
Percentage of operating profit shared by other party	20.00%
Third Party Vendor
Transaction advisory costs recognized as expense	$ 7,400
Series 1 Preferred Stock [Member]
Transaction advisory costs recognized as expense	5,400
Series 1 Preferred Stock [Member] | Intrexon Corporation/Precigen
Consideration transferred	207,300
Preferred Stock Redemption Discount	$ 5,400

Lease expense (Detail)

Lease expense (Detail) $ in Thousands	3 Months Ended	9 Months Ended
	Sep. 30, 2019USD ($)	Sep. 30, 2019USD ($)
Operating lease cost	$ 184	$ 585
Total lease cost	$ 184	$ 585
Weighted-average remaining lease term (years)	2 years 1 month 24 days	2 years 1 month 24 days
Weighted-average discount rate	8.00%	8.00%

Operating lease liabilities (De

Operating lease liabilities (Detail) $ in Thousands	Sep. 30, 2019USD ($)
2019(excluding the nine months ended September 30, 2019)	$ 188
2020	755
2021	491
Total lease payments	1,434
Less: Imputed Interest and Adjustments	110
Present value of lease payments	$ 1,324

Future minimum current and non-

Future minimum current and non-current lease liabilities (Detail) $ in Thousands	Dec. 31, 2018USD ($)
2019	$ 723
2020	736
2021	488
Future minimum lease payments, net	$ 1,947

Leases - Additional Information

Leases - Additional Information (Details) $ in Thousands	Mar. 12, 2019USD ($)ft²	Sep. 30, 2018USD ($)	Sep. 30, 2019USD ($)	Sep. 30, 2018USD ($)	Jan. 01, 2019USD ($)	Dec. 31, 2018USD ($)	Jan. 30, 2018USD ($)ft²
Land Subject to Ground Leases | ft²	1,038
Lessee Operating Lease Monthly Average Rental Payment	$ 2
Operating Lease, Payments			$ 500
Total rent expense		$ 100		$ 500
Operating Lease, Right-of-Use Asset			1,283
Operating Lease, Liability			1,324
Boston, MA
Security Deposit			$ 100			$ 100
Sublease term amendment			Aug. 31, 2021
Operating lease expiration month and year			2016-08
Houston, TX
Operating Lease Area | ft²							210
Operating Leases Future Minimum Monthly Payment Due Through Year 2021							$ 1
Adjustments for New Accounting Pronouncement [Member]
Operating Lease, Right-of-Use Asset					$ 1,600
Operating Lease, Liability					$ 1,600

Stock-Based Compensation Expens

Stock-Based Compensation Expense Included in Statement of Operations (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	$ 1,486	$ 1,480	$ 4,741	$ 6,850
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	339	552	1,068	1,765
General and Administrative Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	$ 1,147	$ 928	$ 3,673	$ 5,085

Stock-Based Compensation - Addi

Stock-Based Compensation - Additional Information (Detail) - USD ($)	Jan. 06, 2019	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Jun. 13, 2019	May 12, 2018	Feb. 15, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock options, granted		140,000	300,500	1,835,755	506,000
Weighted-average grant date fair value		$ 3.05	$ 2.11	$ 1.90	$ 2.49
Number of shares issued for accrued annual performance bonus	446,428
Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended contractual life						52,500	117,500
Director One [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended contractual life						126,700
Additional stock-based compensation expense		$ 0		$ 400,000	$ 500,000
Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended contractual life								751,667
Unvested Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation costs related to unvested restricted stock outstanding		6,700,000		$ 6,700,000
Expected recognition period				1 year 9 months 10 days
Unvested Restricted Common Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation costs related to unvested restricted stock outstanding		$ 2,800,000		$ 2,800,000
Expected recognition period				1 year 5 months 23 days

Fair Value of Stock Options Ass

Fair Value of Stock Options Assumptions Using Black-Scholes Option Valuation Model (Detail)	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019
Risk-free interest rate, Minimum	1.39%	2.82%
Risk-free interest rate, Maximum	1.92%	2.98%
Expected life in years	6 years 3 months	6 years	5 years
Expected volatility, Minimum	72.87%	82.27%
Expected volatility, Maximum	78.34%	83.08%
Expected dividend yield	0.00%	0.00%

Stock Option Activity Under Sto

Stock Option Activity Under Stock Option Plan (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
Number of Shares
Beginning Balance			5,277,085
Granted	140,000	300,500	1,835,755	506,000
Exercised			(482,500)
Cancelled			(1,634,791)
Ending Balance	4,995,549		4,995,549		5,277,085
Options exercisable, at end of period	2,581,327		2,581,327		3,099,935
Options available for future grant	3,971,940		3,971,940
Weighted Average Exercise Price
Beginning Balance			$ 4.24
Granted			2.69
Exercised			3.48
Cancelled			4.11
Ending Balance	$ 3.78		3.78		$ 4.24
Options exercisable, at end of period	$ 4.59		$ 4.59		$ 5.15
Weighted Average Contractual Term (Years)
Outstanding, at end of period			7 years 10 months 2 days
Options exercisable, at end of period			6 years 7 months 6 days		4 years 11 months 4 days
Aggregate Intrinsic Value
Outstanding, at end of period	$ 6,025		$ 6,025
Options exercisable, at end of period	$ 2,425		$ 2,425		$ 88

Summary of Non-Vested Restricte

Summary of Non-Vested Restricted Stock (Detail) - Unvested Restricted Common Stock	9 Months Ended
	Sep. 30, 2019$ / sharesshares
Number of Shares
Beginning Balance | shares	682,070
Granted | shares	1,408,536
Vested | shares	(446,428)
Cancelled | shares	(74,599)
Ending Balance | shares	1,569,579
Weighted Average Grant Date Fair Value
Beginning Balance | $ / shares	$ 3.47
Granted | $ / shares	2.26
Vested | $ / shares	2.24
Cancelled | $ / shares	3.41
Ending Balance | $ / shares	$ 2.91

Preferred Stock - Additional In

Preferred Stock - Additional Information (Detail) - Intrexon Corporation/Precigen - Series 1 Preferred Stock - $ / shares	Jun. 29, 2016	Sep. 30, 2018	Sep. 30, 2018
Equity [Line Items]
Issuance of common stock in licensing agreement (in shares)	100,000	3,847	11,205
Preferred stock, stated value	$ 1,200

Warrants - Additional Informati

Warrants - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	Sep. 12, 2019	Nov. 11, 2018	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019
Fair Value Assumptions Expected volatility Rate Maximum			78.34%	83.08%
Fair Value Assumptions Risk Free Interest Rate Maximum			1.92%	2.98%
Fair Value Assumptions Expected Term1			6 years 3 months	6 years	5 years
Fair Value Assumptions Expected Dividend Rate			0.00%	0.00%
Gross proceeds received			$ 2,971		$ 2,971
Proceeds from private placement	$ 52,500
Non-cash inducement warrant expense			$ 60,751		60,751
Securities Purchase Agreement [Member]
Gross proceeds received		$ 47,100			$ 47,100
Private Placement [Member]
Number of securities into which the class of warrant converted	17,803,031		18,939,394		18,939,394
Warrant Exercise Per share	$ 3.01		$ 3.01		$ 3.01
fair value of adjustment of warrants					$ 18,400
Fair Value Assumptions Expected volatility Rate Maximum					71.00%
Fair Value Assumptions Risk Free Interest Rate Maximum					2.99%
Fair Value Assumptions Expected Dividend Rate					0.00%
Placement agent fees and other expenses	$ 1,100
Private Placement [Member] | New Warrants [Member]
Number of securities into which the class of warrant converted	17,803,031
Warrant Exercise Per share	$ 7
Non-cash inducement warrant expense			$ 60,800		$ 60,800

Joint Venture - Additional Inf

Joint Venture - Additional Information (Detail) - USD ($) $ in Millions	Jul. 05, 2019	Sep. 30, 2019	Jan. 03, 2019	Dec. 31, 2018
Subsidiary or Equity Method Investee [Line Items]
Common stock, shares issued		181,030,020		161,066,136
Eden Bio Cell [Member]
Subsidiary or Equity Method Investee [Line Items]
Equity method investments		$ 0
Ziopharm [Member] | Eden Bio Cell [Member]
Subsidiary or Equity Method Investee [Line Items]
Equity interest in affilated entity	50.00%
Tri Arm [Member] | Eden Bio Cell [Member]
Subsidiary or Equity Method Investee [Line Items]
Equity interest in affilated entity	50.00%
Tri Arm [Member] | License Agreement Terms [Member] | Eden Bio Cell [Member]
Subsidiary or Equity Method Investee [Line Items]
Milestone payment made	$ 10
Conditional milestone amount payable	$ 25
Share Subscription Agreement [Member] | Ziopharm [Member] | Eden Bio Cell [Member]
Subsidiary or Equity Method Investee [Line Items]
Common stock, shares issued			10,000,000
Share Subscription Agreement [Member] | Tri Arm [Member] | Eden Bio Cell [Member]
Subsidiary or Equity Method Investee [Line Items]
Common stock, shares issued			10,000,000