| Cover | Apr. 25, 2023 | Feb. 07, 2023 |
| Cover [Abstract] | ||
| Document Type | 8-K | |
| Document Period End Date | Apr. 25, 2023 | |
| Entity Registrant Name | Illumina, Inc. | |
| Entity File Number | 001-35406 | |
| Entity Incorporation, State or Country Code | DE | |
| Entity Tax Identification Number | 33-0804655 | |
| Entity Address, Address Line One | 5200 Illumina Way | |
| Entity Address, City or Town | San Diego | |
| Entity Address, State or Province | CA | |
| Entity Address, Postal Zip Code | 92122 | |
| City Area Code | 858 | |
| Local Phone Number | 202-4500 | |
| Written Communications | false | |
| Soliciting Material | false | |
| Pre-commencement Tender Offer | false | |
| Pre-commencement Issuer Tender Offer | false | |
| Title of 12(b) Security | Common Stock, $0.01 par value | |
| Trading Symbol | ILMN | |
| Security Exchange Name | NASDAQ | |
| Entity Emerging Growth Company | false | |
| Entity Central Index Key | 0001110803 | |
| Amendment Flag | false |
