Globalscape (GSB) 8-K Changes in Registrant.s Certifying Accountant

Exhibit 16.1

October 15, 2008

Office of the Chief Accountant

Securities and Exchange Commission

100 F Street, NE

Washington, D.C. 20549

Dear Sir/Madam:

We have read the statements included under Item 4.01 in the Form 8-K dated October 15, 2008 of GlobalSCAPE, Inc. (the “Company”) to be filed with the Securities and Exchange Commission and we agree with such statements insofar as they relate to our dismissal and our audits for the years ended December 31, 2007 and 2006, and our reviews of interim financial statements. We cannot confirm or deny that the appointment of Grant Thornton LLP was approved by the Board of Directors, or that they were not consulted prior to their appointment as auditors.

Very truly yours,

PMB Helin Donovan, LLP

/s/ PMB Helin Donovan, LLP

Austin, Texas