Keryx Biopharmaceuticals (KERX) 10-K/A 2005 FY Annual report (amended)

Exhibit 31.1

CERTIFICATION OF PERIODIC REPORT

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Michael S. Weiss, certify that:

1. I have reviewed this Form 10-K/A of Keryx Biopharmaceuticals, Inc.; and

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

Date: May 17, 2006	/s/ Michael S. Weiss
	Michael S. Weiss Chief Executive Officer   (Principal Executive Officer)