Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in this Amendment No. 2 to the Registration Statement (No. 333-221283) on Form S-1 of Yield10 Bioscience, Inc. of our report dated March 30, 2017, relating to the consolidated financial statements of Yield10 Bioscience, Inc. and subsidiaries, appearing in the annual report on Form 10-K of Yield10 Bioscience, Inc. for the year ended December 31, 2016.
We also consent to the reference to our firm under the heading "Experts" in such Registration Statement.
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| /s/ RSM US LLP |
| Boston, Massachusetts |
| December 8, 2017 |
