Senomyx (SNMX) 10-K 2012 FY Annual report

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statement (Form S-3 No. 333-176070) of Senomyx, Inc., and

(2) Registration Statement (Form S-8 Nos. 333-116893, 333-127771, 333-134578, 333-142619, 333-149247, 333-157289, 333-164693, 333-171943, 333-179211, 333-186207) pertaining to the 2004 Equity Incentive Plan and the 2004 Employee Stock Purchase Plan of Senomyx, Inc.;

of our reports dated March 15, 2013, with respect to the consolidated financial statements of Senomyx, Inc. and to the effectiveness of internal control over financial reporting of Senomyx Inc. included in this Annual Report (Form 10-K) for the year ended December 31, 2012.

	/s/ ERNST & YOUNG LLP
San Diego, California
March 15, 2013