Gyre Therapeutics (GYRE) 10-Q2008 Q1 Quarterly report

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Filed: 8 May 08, 12:00am

Date: May 8, 2008

/s/ J. Donald deBethizy

J. Donald deBethizy

President and Chief Executive Officer

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Readability	H.S. sophomore Avg

New words: AAA, agency, AZ, bank, bid, breach, budget, budgeted, calendar, collateral, commencement, composition, comprehensive, cure, deterioration, discounted, dividend, dysfunction, earlier, Education, exceed, experienced, failed, failure, Family, FFELP, flow, formation, framework, gain, guaranteed, HALO, hierarchy, index, industry, lack, led, LIBOR, liquidity, malignant, margin, maximum, mid, negative, observable, par, predetermined, priority, progressed, quoted, recovery, refinancing, repay, roll, selling, settlement, Sirocco, site, uncomplicated, underlying, unobservable, unrealized, unsuccessful, viewed

Removed: accredited, accretion, accurately, American, animal, arise, assessed, assessing, ATP, automatically, barrier, beneficially, biological, biotechnology, board, borrow, cease, Celexa, chemical, citalopram, collectively, combination, commonly, complexity, compliance, computer, contrast, converted, cooperative, defer, deposited, director, discontinue, effected, efficacy, employee, employment, enhancement, enroll, exemption, expired, filed, final, fiscal, highly, hydrobromide, II, IIb, ingredient, length, longer, manufacture, matured, measure, member, molecular, monotherapy, NIST, novelty, offered, office, optimization, order, ordinary, original, parent, past, patient, Pentad, permitted, pipeline, precisely, prescribe, present, producing, promising, proprietary, pursuing, racemate, ratio, retiring, reverse, royalty, satisfied, screening, September, served, significantly, simulation, sophisticated, sophistication, split, test, testing, toxicological, tranche, TRIDMAC, twelve, type, unexercised, Unregistered

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EXHIBIT 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Targacept, Inc. (the “Company”) for the period ended March 31, 2008 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, J. Donald deBethizy, President and Chief Executive Officer of the Company, hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.