Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Basis of Presentation The accompanying unaudited financial statements have been prepared in accordance with U.S. generally accepted accounting principles, or GAAP, for interim financial information, the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements and should be read in conjunction with the Company’s audited financial statements and notes thereto included in its Annual Report on Form 10-K for the year ended December 31, 2014. In the opinion of the Company’s management, all adjustments, consisting of normal recurring adjustments, necessary for a fair presentation of its financial position, operating results and cash flows for the periods presented have been included. Operating results for the three and six months ended June 30, 2015, are not necessarily indicative of the results that may be expected for the full year, for any other interim period or for any future year. Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts of assets, liabilities, revenues and expenses reported in the financial statements and accompanying notes. Actual results could differ from these estimates. Fair Value Measurement The Company follows Financial Accounting Standards Board, or FASB, Accounting Standards Codification, or ASC, Topic 820, Fair Value Measurements and Disclosures Compensation – Stock Compensation The valuation techniques required by ASC 820 may be based on either observable or unobservable inputs. Observable inputs reflect readily obtainable data from independent sources, and unobservable inputs reflect the Company’s market assumptions. These inputs are classified into the following hierarchy: Level 1 Inputs Level 2 Inputs Level 3 Inputs The following tables present the Company’s investments in marketable securities (including, if applicable, those classified on the Company’s balance sheet as cash equivalents) that are measured at fair value on a recurring basis as of June 30, 2015, and December 31, 2014, respectively: June 30, 2015 Quoted Prices in Other Unobservable (Level 3) (in thousands) U.S. Treasury and U.S. or state government agency-backed securities $ 7,810 $ — $ — Corporate debt securities — 13,870 — Municipal bonds — 647 — Accrued interest 77 — — Total investments in marketable securities $ 7,887 $ 14,517 $ — December 31, 2014 Quoted Prices in Other Unobservable (Level 3) (in thousands) U.S. Treasury and U.S. or state government agency-backed securities $ 22,685 $ — $ — Corporate debt securities — 30,372 — Municipal bonds — 1,075 — Accrued interest 241 — — Total investments in marketable securities $ 22,926 $ 31,447 $ — Corporate debt securities and municipal bonds are valued based on various observable inputs such as benchmark yields, reported trades, broker/dealer quotes, benchmark securities and bids. Investments in Marketable Securities Consistent with its investment policy, the Company invests its cash allocated to fund its short-term liquidity requirements with prominent financial institutions in bank depository accounts and institutional money market funds and the Company invests the remainder of its cash in corporate debt securities and municipal bonds rated at least A quality or equivalent, U.S. Treasury notes and bonds and U.S. and state government agency-backed securities. The Company determines the appropriate classification of marketable securities at the time of purchase and reevaluates its classification as of each balance sheet date. All marketable securities owned during the six months ended June 30, 2015 and June 30, 2014, were classified as available-for-sale. The cost of securities sold is based on the specific identification method. Investments in marketable securities are recorded as of each balance sheet date at fair value, with unrealized gains and, to the extent deemed temporary, unrealized losses included in stockholders’ equity. Interest and dividend income on investments in marketable securities, accretion of discounts and amortization of premiums and realized gains and losses are included in interest income in the statement of comprehensive income (loss). An investment in marketable securities is considered to be impaired when a decline in fair value below its cost basis is determined to be other than temporary. The Company evaluates whether a decline in fair value of an investment in marketable securities below its cost basis is other than temporary using available evidence. In the event that the cost basis of the investment exceeds its fair value, the Company evaluates, among other factors, the amount and duration of the period that the fair value is less than the cost basis, the financial health of and business outlook for the issuer, including industry and sector performance, and operational and financing cash flow factors, overall market conditions and trends, the Company’s intent to sell the investment and whether it is more likely than not the Company would be required to sell the investment before its anticipated recovery. If a decline in fair value is determined to be other than temporary, the Company records an impairment charge in the statement of comprehensive income (loss) and establishes a new cost basis in the investment. Revenue Recognition The Company uses the revenue recognition guidance established by ASC Topic 605, Revenue Recognition Multiple Element Arrangements, Non-refundable upfront fees, which may include, for example, an initial payment upon effectiveness of the contractual relationship, payment representing a common stock purchase premium or payment to secure a right for a future license, are recorded as deferred revenue and recognized into revenue as license fees and milestones from collaborations on a straight-line basis over the estimated period of the Company’s substantive performance obligations. If the Company does not have substantive performance obligations, it recognizes non-refundable upfront fees into revenue through the date the deliverable is satisfied. Revenue for non-refundable payments based on the achievement of milestone events under collaboration agreements is recognized in accordance with ASC 605, Subtopic 28, Milestone Method Research and development costs that are reimbursable under collaboration agreements are recorded in accordance with ASC 605, Subtopic 45, Principal Agent Considerations Grant payments received prior to the Company’s performance of work required by the terms of the award are recorded as deferred revenue and recognized as grant revenue as the Company performs the work and incurs qualifying costs. Service revenue is earned and recognized as research or development is performed and related expenses are incurred. Income Taxes The Company uses the liability method in accounting for income taxes as required by ASC Topic 740, Income Taxes, Net Income or Loss Per Share The Company computes net income or loss per share in accordance with ASC Topic 260, Earnings Per Share Three Months Ended June 30, Six Months Ended June 30, 2015 2014 2015 2014 Basic and diluted: Net loss $ (4,336 ) $ (8,136 ) $ (11,088 ) $ (23,135 ) Weighted average common shares - basic and diluted 33,887,176 33,786,686 33,842,029 33,766,911 Basic and diluted EPS $ (0.13 ) $ (0.24 ) $ (0.33 ) $ (0.69 ) Common share equivalents consist of the incremental common shares that would be outstanding upon the exercise of stock options, calculated using the treasury stock method. For the three- and six-month periods ended June 30, 2015, and June 30, 2014, the Company excluded all common share equivalents from the calculation of Diluted EPS because the Company had a net loss in those periods. As a result, Diluted EPS is identical to Basic EPS for those periods. If the Company had been in a net income position for the three months ended June 30, 2015 and June 30, 2014, 3,046,993 and 4,785,391 shares, respectively, subject to outstanding stock options may have been included in the calculation of common share equivalents using the treasury stock method. If the Company had been in a net income position for the six months ended June 30, 2015 and June 30, 2014 3,420,839 and 4,873,288 shares, respectively, subject to outstanding stock options may have been included in the calculation of common share equivalents using the treasury stock method. Common Stock and Stock-Based Compensation During the six months ended June 30, 2015, the Company issued 31,900 shares of common stock upon the exercise of stock options. The Company issued 75,556 shares of common stock upon the exercise of stock options during the year ended December 31, 2014. During the six months ended June 30, 2015, the Company granted to employees options to purchase an aggregate of 111,025 shares of common stock, of which 42,588 remain outstanding at June 30, 2015. The remaining stock options have an estimated aggregate fair value, using the Black-Scholes-Merton formula, of $61,000. The Company is recording this amount, as adjusted for forfeitures, as stock-based compensation on a straight line basis over 16 quarters beginning on the last day of the respective quarters in which the grants were made. During the three months ended June 30, 2015, the Company accelerated the vesting of 47,032 stock options and 61,600 stock awards upon the termination of employment of the respective award recipients resulting in $278,000 of stock-based compensation expense. During the six months ended June 30, 2015, the Company accelerated the vesting of 142,634 stock options and 125,050 stock awards upon the termination of employment of the respective award recipients resulting in $698,000 of stock-based compensation expense. Accumulated Other Comprehensive Income or Loss Accumulated other comprehensive income or loss, as presented in stockholders’ equity on the Company’s balance sheet, reflects the cumulative net unrealized gains or losses on available-for-sale securities for all periods. The table below reflects changes in accumulated other comprehensive income for the six months ended June 30, 2015, in thousands. Accumulated other comprehensive income, January 1, 2015 $ 4 Unrealized loss on available-for-sale securities, net (12 ) Net realized gains on available-for-sale securities reclassified out of other comprehensive income (2 ) Income taxes 21 Accumulated other comprehensive income, June 30, 2015 $ 11 Long-lived Assets Property and equipment consists primarily of laboratory equipment, office furniture and fixtures and leasehold improvements and is recorded at historical cost, net of accumulated depreciation. Depreciation is computed using the straight-line method over the estimated useful lives of the assets. Equipment is typically depreciated over 3 to 5 years, office furniture and fixtures are typically depreciated over 7 years, and leasehold improvements are typically amortized over the lesser of the asset life or the lease term. The Company capitalizes the costs of intellectual property acquired or licensed from external sources as intangible assets if, at the time of acquisition, the intellectual property has reached technological feasibility. The cost of intellectual property acquired or licensed from external sources that has not reached technological feasibility at the time of acquisition or that has no expected future use is charged to research and development expense as incurred. The Company records all other charges related to the filing, prosecution and maintenance of patents to expense as incurred. The Company assesses the net realizable value of its long-lived assets, including capitalized intellectual property, and evaluates these assets for impairment whenever events or changes in business circumstances indicate that the carrying amount of an asset may not be recoverable. An impairment charge would be recognized when the estimated undiscounted future cash flows expected to result from the use of the asset and its eventual disposition are less than its carrying amount. An impairment charge, if recognized, would be based on the excess of the carrying value of the impaired asset over its estimated fair value. As a result of the decision to discontinue development of TC-5214, the Company determined during 2014 the carrying value of the related capitalized intellectual property was not recoverable and, accordingly, recorded an impairment charge for its full carrying value of $89,000. For an asset classified as held for sale, the Company considers the asset impaired when its carrying amount exceeds fair value less its cost to sell. Fair value is determined in the same manner as an impaired long-lived asset that is held and used. The Company entered into the Merger Agreement during the six months ended June 30, 2015 (see Note 1). In preparing for the planned closing of the merger, the Company identified property and equipment that will not be utilized whether or not the Proposed Merger is completed. As a result, the Company has classified certain furniture as “assets held for sale” on its balance sheet as of June 30, 2015, assessed fair value based on Level 2 inputs and recorded an impairment loss of $134,000 in its statements of comprehensive income for the three and six months ended June 30, 2015. Commitments and Contingencies Under employment agreements with two former executive officers, the Company paid severance equal to each former executive’s respective regular base salary as of their respective termination date, for twelve months; their respective target bonus for 2015; and their respective health and life insurance benefits coverage provided to them as of their respective termination date, for twelve months. These payments and benefits, which represent an aggregate amount of $332,000 and $699,000 for the three and six months ended June 30, 2015, respectively, were recorded as reduction-in-force expense. In addition, the Company accelerated the vesting of 47,032 and 114,885, employee stock options, respectively, and 40,000 and 85,000 stock awards, respectively, awarded to the former executives, resulting in reduction-in-force expense of $242,000 and $560,000, respectively, for the three and six months ended June 30, 2015. Recent Accounting Pronouncements In May 2014, the FASB issued Accounting Standards Update 2014-09, Revenue from Contracts with Customers |