News Release | Bayer HealthCare AG Corporate Communications 51368 Leverkusen Germany Tel.: +49-214 30-1 www.presse.bayer.com |
International Diabetes Federation recommends Acarbose therapy
for the prevention of type 2 diabetes
Berlin/Barcelona – The International Diabetes Federation (IDF) has published a new consensus statement on type 2 diabetes prevention which recommends considering intervention with acarbose (Glucobay®*) when lifestyle intervention alone has failed. This guideline presents best practice care for individuals with prediabetes, as agreed by a panel of internationally respected diabetologists, which was presented at the 2nd International Congress on Prediabetes and the Metabolic Syndrome held in Barcelona, Spain, April 25-28, 2007, and was published in the May issue of Diabetic Medicine1.
Professor Paul Zimmet, Director of the International Diabetes Institute and co-author of the consensus statement, emphasized the need for doctors and governments to act now. “With 246 million people with diabetes now and 380 million people with diabetes by 20252, diabetes is set to heavily burden national economies,” he said. “Type 2 diabetes can be prevented, but it will take enormous political will on the part of governments to make this a reality.”3
“There is overwhelming evidence that lifestyle changes can help prevent the development of type 2 diabetes in those at high risk.”3 said Professor Sir George Alberti, Past President of the IDF and co-author of the consensus statement. There was further acknowledgement that some patients will require pharmacotherapy in addition to lifestyle modification.1
Acarbose and metformin are the only pharmacotherapies recommended by the IDF.1 The recommendation for acarbose is supported by the Study to Prevent Non-Insulin Dependent Diabetes Mellitus (STOP-NIDDM), a randomised, placebo-controlled trial carried out in Europe and North America with an average treatment duration of 3.3 years.
The study shows that treatment with acarbose significantly reduced the risk of progressing from prediabetes to type 2 diabetes by 36%, as well as significantly increasing the rate of reversion from prediabetes to normal glucose tolerance.4 In addition, acarbose significantly reduced the risk of a first cardiovascular event by 49%, including a 91% reduction in the risk of myocardial infarction.5
A new study, the Acarbose Cardiovascular Evaluation (ACE) trial, will further investigate the cardiovascular benefits of acarbose.6 ACE is a randomised, placebo-controlled design study, which will assess, as the primary endpoint, the effect of acarbose on the occurrence of new cardiovascular events (secondary CVD prevention). Final trial results are expected in 2013.
Additional Information
Three-step IDF strategy for type 2 diabetes prevention1
Step 1 is to identify individuals at high risk of developing type 2 diabetes through opportunistic screening in the clinic. Healthcare personnel are advised to use simple, practical and inexpensive tools, such as the Finnish Diabetes Risk Score (FINDRISC) questionnaire7 for these individuals.
Step 2 is to measure a high-risk individual’s level of risk. The IDF consensus statement recommends measuring fasting blood glucose, which is straightforward and quick in the clinical setting; however, this should be followed by an oral glucose tolerance test (OGTT) to confirm a diagnosis of prediabetes or diabetes.
Step 3 is intervention to lower an individual’s level of risk. In the first instance, this should take the form of lifestyle intervention: adopting and maintaining a healthy diet, taking more exercise and aiming for sustainable weight loss. However, IDF recommends that “some patients, who cannot change their lifestyle sufficiently, will also require pharmacotherapy.”1
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Bayer Schering Pharma
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Berlin, May 8, 2007
ym (2007-0247)
Contact
Yvonne Möller
Tel.: +49 (0) 30 468 17 389, fax: +49 (0) 30 468 16 710
E-mail: yvonne.moeller@bayerhealthcare.com
References
1. Alberti KG, Zimmet P and Shaw J. International Diabetes Federation: a consensus on type 2 diabetes prevention. Diabetic Medicine 2007;24:451–63.
2. International Diabetes Federation. Diabetes Atlas, Third Edition, 2006. Available at www.eatlas.idf.org.
3. Governments must act on biggest epidemic in human history – new IDF consensus on prevention of diabetes is launched [press release]. International Diabetes Federation, Barcelona, 26 April 2007.
4. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 2002;359:2072–7.
5. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 2003;290:486–94.
6. Holman RR and Pan CY. Acarbose cardiovascular evaluation (ACE) in prediabetic subjects [abstract]. 2nd International Congress on Prediabetes and the Metabolic Syndrome, Barcelona, Spain, 24–28 April 2007.
7. Lindstrom J, Tuomilehto J. The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care 2003;26:725–31.