As filed with the Securities and Exchange Commission on March 8, 2004
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_________________________
FORM 20-F
[ ] REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE
SECURITIES EXCHANGE ACT OF 1934
OR
[X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
For the fiscal year ended December 31, 2003
OR
[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
For the transition period from _______ to _______
Commission file number 001-16143
_________________________
Schering AKTIENGESELLSCHAFT
(Exact name of Registrant as specified in its charter)
Not Applicable (Translation of Registrant's name into English) | Federal Republic of Germany (Jurisdiction of incorporation or organization) |
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Muellerstrasse 178
13353 Berlin
Federal Republic of Germany
(Telephone: (49-30) 468-1111)
(Address and telephone number of principal executive offices)
_________________________
Securities registered or to be registered pursuant to Section 12(b) of the Act.
Title of each class American Depositary Shares, evidenced by American Depositary Receipts, each representing one Ordinary Share Ordinary Shares, no par value* | Name of each exchange on which registered New York Stock Exchange |
Securities registered or to be registered pursuant to Section 12(g) of the Act.
None
Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act.
None
Indicate the number of outstanding shares of each of the issuer's classes of capital or common stock as of December 31, 2003:
194,000,000 Ordinary Shares
_________________________
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.
YES [X] NO [ ]
Indicate by check mark which financial statements item the registrant has elected to follow.
ITEM 17 [ ] ITEM 18 [X]
* Not for trading but only in connection with the registration of the American Depositary Shares, pursuant to the requirements of the Securities and Exchange Commission.
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Schering Aktiengesellschaft is incorporated as a stock corporation under the laws of the Federal Republic of Germany. Unless otherwise specified or the context requires otherwise:
references to " Schering AG" are to Schering Aktiengesellschaft, the ultimate parent company of the Schering AG Group;
references to the " Schering AG Group", "the Group", "we", "us" and "our" are to Schering Aktiengesellschaft together with its consolidated subsidiaries;
references to "euro", "€" and "cents" are to the currency introduced at the start of the third stage of the European Economic and Monetary Union pursuant to the Treaty establishing the European Economic Community, as amended by the Treaty on the European Union; and
references to "U.S. dollars", "USD", "$" and "U.S. cents" are to the United States dollar and cents, the legal currency of the United States of America.
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Unless otherwise specified, all references in this annual report to a "fiscal year" or "year" of Schering AG refer to a twelve month financial period ended December 31.
We prepared our Consolidated Financial Statements in accordance with the International Financial Reporting Standards (IFRS) of the International Accounting Standards Board, formerly known as International Accounting Standards (IAS). IFRS differ in certain material respects from United States Generally Accepted Accounting Principles. You can read about some of the principal differences in Note 37 to our Consolidated Financial Statements. Note 37 to our Consolidated Financial Statements also provides a reconciliation of our Consolidated Financial Statements to United States Generally Accepted Accounting Principles.
Unless otherwise specified, all shares and share related information (such as per share information and share price information) have been adjusted to give effect, retroactively, to Schering AG's three-for-one share split effective on June 1, 2000.
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Schering AG and Schering-Plough Corporation are unaffiliated companies that have been totally independent of each other for many years. For a brief description of the historical relationship between the two companies, see "Item 4-Information on the Company-The Schering AG Group-History". Schering AG and Schering-Plough Corporation have entered into an agreement relating to their respective use of the word "Schering". Subject to certain limited exceptions, Schering AG may not use the Schering name for commercial purposes relating to its healthcare business in the United States and Canada. Schering AG operates its pharmaceutical business in the United States and Canada under the Berlex trade name. See "Item 4-Information on the Company-Patents and Other Intellectual Property" for a description of th is agreement between Schering AG and Schering-Plough Corporation.
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Some statements contained in this annual report constitute forward-looking statements. The words "believe", "anticipate", "expect", "intend", "estimate", "plan", "assume", "will", "may", "should", "risk" and other similar expressions are predictions of or indicate future events and future trends which do not relate to historical matters identify forward-looking statements. In addition, this annual report includes forward-looking statements relating to our potential exposure to various types of market risks, such as foreign exchange rate risk, interest rate and other risks related to financial assets and liabilities and equity price risk. You should not rely on forward-looking statements because they involve known and un known risks, uncertainties and other factors which are, in many cases, beyond our control and may cause our actual results, performance or achievements to differ materially from anticipated future results, performance or achievements expressed or implied by the forward-looking statements and from past results, performance or achievements. Certain factors that may cause such differences include but are not limited to the following:
governmental factors, including legislative and regulatory changes;
difficulties and uncertainties related to new product development;
delays and uncertainties in the product approval process;
factors affecting our ability to obtain or maintain patent or trademark protection for our key products and processes;
factors adversely affecting the sale of our key products, including safety or efficacy concerns, increased competition from other products or manufacturing or supply disruptions;
competitive factors, including pricing and product initiatives of our competitors;
legal factors, including product liability or other liability claims;
human resources factors, including our ability to attract and retain qualified personnel;
economic factors over which we have no control, including changes in inflation, interest rates and foreign currency exchange rates, and overall economic conditions particularly in areas such as Asia, Eastern Europe and Latin America;
adverse developments in our relationships with our development, manufacturing and marketing partners;
the impact of future investments, acquisitions and dispositions, and any delays, unexpected costs or other problems experienced in connection with such transactions, including any liabilities associated with the sale of our minority interest in Aventis CropScience;
changes in environmental laws and regulations, which could cause us to incur significant costs in connection with ongoing compliance or liability for remediation; and
other risks, uncertainties and factors inherent in our business.
For further discussion of these factors, see "Item 3-Key Information-Selected Financial Data" and "-Risk Factors", "Item 4-Information on the Company", "Item 5-Operating and Financial Review and Prospects", and "Item 11-Quantitative and Qualitative Disclosures about Market Risk".
You are cautioned not to place undue reliance on these forward-looking statements. These forward-looking statements are made as of the date of this registration statement and are not intended to give any assurance as to future results.
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Not applicable.
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Not applicable.
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RISK FACTORS
You should carefully consider the risks described below before deciding whether to invest in the American Depositary Receipts (ADRs). Additional risks not currently known to us or that we now consider immaterial may also harm our business, financial condition or results of operations and the value of your investment.
If any of these risks actually occur, our business, financial condition or results of operations could be negatively affected. In that case, the trading price of our ADRs could decline and you may lose all or a part of your investment in the ADRs.
Our business is subject to extensive governmental regulation including price controls
The research, development, testing, manufacturing and marketing of our products are subject to extensive governmental regulation. Governmental regulation includes inspection of and controls over testing, manufacturing, safety and environmental controls, efficacy, labeling, record keeping, sale and distribution of pharmaceutical products. Governmental regulation substantially increases the cost of developing, manufacturing and selling our products.
The approval process for new products is generally lengthy, expensive and subject to unanticipated delays. Currently, we are actively pursuing marketing approval for a number of our products from regulatory authorities in a number of countries, including the European Union, the United States and Japan. Continued growth in our revenues and profits will depend, in part, on the timely and successful introduction and marketing of some or all of such products. We cannot give you any assurance as to when or whether such approvals from regulatory authorities will be received. Failure to obtain, or delays in obtaining, regulatory clearance to market new products or existing products for new indications, as well as other regulatory actions, could adversely affect our results of operations. Even after a product is approved, it may be sub ject to regulatory action based on newly discovered facts about the safety or effectiveness of the product, on any activities which regulatory authorities consider to be improper or on changes in regulatory policy. Regulatory action may adversely affect the marketing of the product, require changes in the product's labeling or even lead to withdrawal of regulatory approval.
In addition, in order to obtain (and maintain) marketing authorizations for our products, we must comply with a variety of governmental requirements and we are subject to governmental price-related interventions. These include the requirement to present, in addition to clinical studies proving efficacy, quality and safety of products, studies demonstrating health economic advantages including quality of life, studies proving so-called clinical excellence and submission to price and reimbursement negotiations for already marketed products as well as newly launched products. Governments and major healthcare providers in particular markets are able to exert substantial pressure on market prices. Some governments in Europe, for instance, are exerting strong downward pressure on the prices of the manufacturers by forcing doctors by way of incentives or sanctions to prescribe low cost medicines. The European Commission's efforts to harmonize the disparate national health systems has so far proven not to be successful, leaving the industry exposed to ad hoc national cost containment measures. These measures particularly target manufacturers' prices. As a consequence, parallel trading of products is encouraged as arbitrageurs take advantage of the price differential between those countries where governmental interventions have succeeded in depressing prices and those countries where competitive forces are allowed. Furthermore, central government control of market prices exists in major markets such as Japan and Brazil through limits on the opportunities for financial return and growth in these markets as well as the introduction of new products.
In the United States, the products marketed by the Group’s subsidiaries are subject to a variety of programs with respect to the reimbursement by federal, state and local government entities for drugs and related products purchased by individuals, who are eligible for certain governmental health benefits. From time to time, proposals are made calling for substantial changes to the U.S. healthcare system; additionally, federal, state and local government entities have pursued methods to reduce the cost of drugs and related products for which they pay. Changes to existing governmental programs could have an impact on government reimbursement for the Group’s products in the U.S. In addition, U.S. drug companies are periodically named as defendants in lawsuits brought by government entities and other groups regarding the pricing of their products for the purpose of government reimbursement.
Exchange rate fluctuations could affect our operating result and our ability to price our products competitively
Our operations are conducted by entities in many countries and, accordingly, a substantial portion of our sales and production costs are denominated in currencies other than the euro. As a result, fluctuations between the value of the euro and other major currencies, in particular the U.S. dollar, the Japanese yen and the British pound sterling, may affect our operating results. For example, the depreciation of the U.S. dollar against the euro had a negative impact on the reported sales of our U.S. subsidiaries for inclusion in the Schering AG Group's Consolidated Financial Statements in 2002 and 2003. Moreover, some entities in our Group import and export goods and services in currencies other than their own functional currencies. The results of such entities could therefore be affected by currency fluctuations arising between the transaction dates and the settlement dates for these transactions. We currently hedge part of these exposures through financial instruments in the form of forward contracts and currency swaps and options. We cannot assure you that exchange rate fluctuations will not adversely affect our business, financial condition or results of operations in the future.
In addition, many of our competitors are based in Japan, the United States and other countries whose currencies fluctuate against the euro. Our business will suffer if we are unable to compensate for any competitive advantage others may derive from having a substantial portion of their costs based in a weaker currency. If our competitors benefit from weaker currencies by offering their products at prices that are lower than ours, we may need to reduce our prices to make our products competitive, lowering our profit margins.
A decline in the value of the Euro could reduce the value of your investment and any dividends you receive
Fluctuations in the exchange rate between the U.S. dollar and the euro will affect the U.S. dollar equivalent of the euro price per ADR and the U.S. dollar value of any cash dividends. If the value of the euro relative to the U.S. dollar declines, the market price of the ADRs is likely to be adversely affected. Any decline in the value of the euro would also adversely affect the U.S. dollar amounts received by shareholders on the conversion of any cash dividends paid in euro on the ADRs.
Resources devoted to research and development may not yield new products that achieve commercial success
Like other pharmaceutical companies, we devote substantial resources to research and development. In the pharmaceutical industry, research and development is both expensive and time-consuming and entails considerable uncertainty. The process of developing a new pharmaceutical product from discovery through testing and registration to initial product launch typically takes between eight and twelve years, but this period varies considerably from product to product and country to country. Because of the complexities and uncertainties associated with pharmaceutical research, we cannot ensure that products currently under development by us will survive the development process and ultimately obtain the regulatory approvals needed to market such products successfully. There can be no assurances regarding the development of and commerc ial success of any of the products in our current pipeline. Moreover, even after a product has received regulatory approval and has been launched, the profile of the product may exhibit unanticipated side effects which could lead to its withdrawal from the market or a significant decrease in the product's sales.
We depend on our patents and proprietary rights; several of our patents will expire
Our success depends, in large part, on our ability to protect our current and future products and to defend our intellectual property rights. We have been issued numerous patents covering our active ingredients, pharmaceutical formulations and combinations, manufacturing processes, technologies and products, and have filed, and expect to continue to file, patent applications seeking to protect such newly developed technologies and products. Since many of the products that we sell are licensed to us by third parties, we also rely on the patents held by such third parties. We cannot be sure that patents will be issued with respect to any of our patent applications or that any existing or future patents issued to or licensed by us will provide us with competitive advantages or will not be challenged, invalidated or circumvented by competitors.
We also rely on trade secrets, unpatented proprietary know-how and continuing technological innovation that we seek to protect, in part by confidentiality agreements with licensees, suppliers, employees and consultants. We cannot assure that these agreements will not be breached. We also cannot be certain that we will have adequate remedies for any breach. Furthermore, we cannot be sure that our trade secrets and proprietary technology will not otherwise become known or be independently developed by our competitors or, if patents are not issued with respect to products arising from research, that we will be able to maintain the confidentiality of information relating to such products.
We may be required to defend ourselves against charges of infringement of patent or proprietary rights of third parties. Such defense could require us to incur substantial expenses and to divert significant efforts of our technical and management personnel, and could result in our loss of rights to develop or make certain products or require us to pay monetary damages or royalties to license proprietary rights from third parties. Although patent and intellectual property disputes in the pharmaceutical product area have often been settled through licensing or similar arrangements, costs associated with such arrangements may be substantial and could include ongoing royalties. Furthermore, we cannot be certain that the necessary licenses would be available to us on terms we believe to be acceptable. We cannot assure you that an ad verse outcome of any dispute with respect to patents or other proprietary rights will not adversely affect our competitive position, financial condition or results of operations.
During the period of patent protection, a product is normally only subject to competition from alternative products. Following patent expiration, the manufacturer of the patented product is likely to face increased competition through the entry into the market of generic products and a subsequent decline in market share and sales revenues. For example, the patent protection for Fludara® in the United States has expired in 2003, and we have experienced a decrease in sales. We similiarly experienced a significant decline in sales of Betapace® when its patent protection expired. Certain of our key products are no longer protected by patents (or other regulatory exclusivity measures) in our major markets, or protection for these products will expire in the near future. Many of our fertility control p roducts have no patent protection remaining. The expiration of certain patents could adversely affect the pricing and sales with respect to these products and, consequently, could adversely affect our business, financial condition or results of operations.
Our industry is competitive and experiences rapid technological change
We compete in the pharmaceutical industry, which is characterized by intense competition and rapid technological change. We compete with companies around the world, including large, well-established pharmaceutical and chemical companies, research and development firms, universities and other research institutions. Many of our competitors have significant financial, marketing, sales, development and technical resources. Our competitors may succeed in developing technologies and products that are more effective or cheaper than the ones which we may develop. In addition, the continuing consolidation of companies in the pharmaceutical industry might increase competitive pressures as larger suppliers are able to offer a broader product line. We cannot assure you that these developments will not render our technologies and products o bsolete and uncompetitive. Delays or unanticipated increases in the costs of development or our failure to obtain regulatory approval or market acceptance for new products and technologies could further adversely affect our competitive position and results of operations.
We depend on sales of key products
We derived approximately 34% of our net sales in 2003 from sales of four key products: Betaferon® (which is sold in the United States and Canada under the Betaseron® trademark) (16% of net sales), Magnevist® (6%), Yasmin® (6%) and Iopamiron® (5%). We believe that these key products will constitute a significant portion of net sales for the foreseeable future. Accordingly, any factor adversely affecting the sale of these key products individually or collectively could have a material adverse effect on our results of operations. The sale of these key products could be adversely affected by a number of factors, including manufacturing or supply interruptions, the development of new competitive pharmaceuticals to treat the conditions addressed by the ke y products, technological advances, factors affecting the cost of production, marketing or pricing actions by one or more of our competitors, changes in prescribing practices, changes in the reimbursement policies of third-party payors, product liability claims or other factors.
We may incur significant liabilities relating to the sale of our minority interest in Aventis CropScience
We may be subject to potential liabilities under the stock purchase agreement for the sale of our minority interest in Aventis CropScience for claims made by Bayer CropScience AG with respect to certain indemnities and representations and warranties, relating mainly to financial statement guarantees, environmental matters, tax liabilities, the funding of employee benefit plans, social contributions and product liabilities. Bayer CropScience has initiated arbitration proceedings alleging the violation of a financial statement guarantee for which Bayer CropScience is demanding payments of damages. Bayer CropScience has further notified Schering AG in several other cases about potential violations of provisions of the Aventis CropScience Stock Purchase Agreement that might lead to damages. Our liabilities under these claims and other future claims may be significant.
Existing insurance coverage may turn out to be inadequate
We are aiming at adequately covering foreseeable risks by insurance. Such insurance coverage, however, may turn out to not fully cover the risks to which the company is exposed. For certain risks, adequate insurance coverage may not be available on the market or not at acceptable conditions.
Our industry is susceptible to product-related liabilities
Like all pharmaceutical companies, we face potential significant risk of loss related to the use of products we market in the United States and in other regions from actions such as lawsuits. We cannot assure you that we can avoid such claims. We cannot be sure that our product liability insurance will be adequate to cover such claims or that we will be able to get adequate insurance coverage in the future at acceptable costs. A successful product liability claim in excess of our coverage could require us to pay substantial sums. Even unsuccessful product liability claims could result in the expenditure of funds in litigation and the diversion of management time and resources and could damage our reputation and impair the marketability of our products. We are currently involved in a number of product liability cases claiming da mages as a result of the use of our products. We do not believe, however, that the potential costs and liabilities associated with such matters are likely to have a material adverse effect on our results of operations or liquidity.
We depend on the services of our key managerial and scientific personnel
Our success depends upon the continued contributions of our key managerial and scientific personnel, many of whom have many years of experience at the Schering AG Group and would be difficult to replace. Competition for qualified personnel is intense in our industry, and we may not be successful in hiring and retaining people. If we lose the services of any key managerial or scientific personnel or cannot attract and retain other qualified personnel, our business could suffer.
ADR holders may not be able to vote or to participate in offerings of new shares
If you hold our ordinary shares in the form of ADRs, you generally can exercise your voting rights for the shares which underlie your ADRs only by instructing the depositary how to exercise these voting rights. You may not receive voting materials in time to instruct the depositary how to vote your ADRs, and as a result you may not have the opportunity to exercise a right to vote.
U.S. holders of ADRs also may not be able to participate in any offer of new shares to existing shareholders on the basis of their subscription rights because of restrictions on the offer and sale of securities in the United States under U.S. securities laws and regulations.
SELECTED FINANCIAL DATA
The selected consolidated financial data for each of the years in the three-year period ended December 31, 2003, has been derived from our Consolidated Financial Statements and the related Notes appearing elsewhere in this annual report. The selected consolidated financial data at year end and for each of the years in the two-year period ended December 31, 2000, has been derived from our Consolidated Financial Statements not included in this annual report.
We prepared our Consolidated Financial Statements in accordance with the International Financial Reporting Standards (IFRS) of the International Accounting Standards Board, formerly known as International Accounting Standards (IAS). For periods ending on or prior to December 31, 1998, the Consolidated Financial Statements also were in accordance with the German Commercial Code (Handelsgesetzbuch). Differences between IFRS and the German Commercial Code were not material for periods ending on or prior to December 31, 1998. Following a revision to the German Commercial Code in 1998 to facilitate capital raising by German companies in the international capital markets (Kapitalaufnahme-Erleichterungsgesetz), we were permitted to prepare our Consolidated Financial Statements solely in accordance with IFRS, and no longe r required to follow the German Commercial Code. We elected to do so commencing in fiscal 1999. IFRS differ in certain material respects from United States Generally Accepted Accounting Principles. You can read about some of the principal differences in Note 37 to our Consolidated Financial Statements. Note 37 to our Consolidated Financial Statements also provides a reconciliation of our Consolidated Financial Statements to United States Generally Accepted Accounting Principles.
Amounts shown in U.S. dollars have been translated from euro amounts to U.S. dollars at the rate of $1.2597 per €1.00, the noon buying rate on December 31, 2003.
You should read these selected consolidated financial data together with "Item 5-Operating and Financial Review and Prospects" and our Consolidated Financial Statements appearing elsewhere in this annual report.
Consolidated Income Statement Data | |
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| Year ended December 31, |
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| 2003 | 2003 | 2002 | 2001 | 2000 | 1999 |
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| $(3) | € | € | € | € | € |
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| (in millions, except per share data) |
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IFRS: | | | | | | |
Net sales | 6,082 | 4,828 | 5,023 | 4,842 | 4,493 | 3,674 |
Operating profit | 864 | 686 | 741 | 668 | 640 | 536 |
Financial result | 19 | 15 | (23) | 30 | (5) | (77) |
Profit from ordinary activities | 883 | 701 | 1,145 | 698 | 635 | 459 |
Income taxes | (321) | (255) | (276) | (270) | (290) | (181) |
Net profit before minority interest | 562 | 446 | 869 | 428 | 345 | 278 |
Minority interest | (4) | (3) | (2) | (10) | (9) | (6) |
Net profit | 558 | 443 | 867 | 418 | 336 | |
Weighted average number of shares outstanding(1) | 194.41 | 194.41 | 197.30 | 198.00 | 198.00 | 201.06 |
Earnings per share (basic)/ADS(1) | 2.87 | 2.28 | 4.39 | 2.11 | 1.70 | 1.35 |
Earnings per share (diluted)/ADS(1) | 2.87 | 2.28 | 4.38 | 2.10 | 1.68 | 1.35 |
Dividends per share/ADS(1)(2) | 1.17 | 0.93 | 0.93 | 0.83 | 1.00 | 0.83 |
United States GAAP: | | | | | | |
Net profit | 616 | 489 | 848 | 403 | 306 | 248 |
Earnings per share (basic)/ADS(1) | 3.17 | 2.52 | 4.30 | 2.04 | 1.55 | 1.23 |
Earnings per share (diluted)/ADS(1) | 3.16 | 2.51 | 4.29 | 2.03 | 1.53 | 1.23 |
Consolidated Balance Sheet Data (at period end date) | |
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| As of December 31, |
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| 2003 | 2003 | 2002 | 2001 | 2000 | 1999 |
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| $(3) | € | € | € | € | € |
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| (in millions, except per share data) |
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IFRS: | | | | | | |
Total assets | 6,789 | 5,389 | 5,392 | 5,263 | 5,206 | 4,629 |
Cash, cash equivalents and marketable securities | 931 | 739 | 657 | 295 | 652 | 583 |
Total long term bank debt | 45 | 36 | 38 | 45 | 43 | 58 |
Pension provisions | 726 | 576 | 560 | 1,035 | 1,278 | 1,201 |
Minority interest | 20 | 16 | 15 | 15 | 92 | 55 |
Total shareholders' equity | 3,656 | 2,902 | 2,934 | 2,556 | 2,297 | 2,098 |
United States GAAP: | | | | | | |
Total shareholders' equity | 3,561 | 2,827 | 2,794 | 2,457 | 2,304 | 2,061 |
(1) All share and per share data for 2000 and 1999 have been adjusted to give effect, retroactively, to Schering AG's three-for-one share split effective on June 1, 2000. (2) Includes bonus dividends of €0.33 per share declared with respect to 1999 and 2000. The dividend with respect to 2003 is subject to approval at the Annual General Meeting to be held on April 16, 2004. (3) The 2003 figures have been translated solely for the convenience of the reader at an exchang rate of $1.2597 to €1.00, the noon buying rate on December 31, 2003.
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EXCHANGE RATES
Schering AG pays any dividends on its shares in euro. Furthermore, prices for Schering AG's shares on the Frankfurt Stock Exchange are quoted in euro. Fluctuations in the exchange-rate between the euro and the U.S. dollar will affect:
the U.S. dollar equivalent of the euro price of our shares listed on the Frankfurt Stock Exchange and, as a result, the market price of the ADRs in the United States;
the U.S. dollar equivalent of cash dividends on the shares paid in euro; and
our earnings.
The noon buying rate for the euro in The City of New York for cable transfers as certified for customs purposes by the Federal Reserve Bank of New York on February 20, 2004, was $1.2563 per €1.00.
The following table sets forth the average noon buying rate for the euro for each of the previous five years:
Year | Average(1) (Dollar per €1.00) |
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1999 | 1.0587 |
2000 | 0.9207 |
2001 | 0.8909 |
2002 | 0.9496 |
2003 | 1.1360 |
(1) Average of the noon buying rates on the last day of each month during the year. |
The following table sets forth the high and low noon buying rate for the euro for each of the previous six months:
| High | Low |
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2003 | (Dollar per €1.00) |
September | 1.1650 | 1.0845 |
October | 1.1833 | 1.1596 |
November | 1.1995 | 1.1417 |
December | 1.2597 | 1.1956 |
2004 | | |
January | 1.2853 | 1.2389 |
February | 1.2848 | 1.2426 |
For a more complete discussion of exchange-rate fluctuations and the hedging techniques we use to manage our exposure to these fluctuations, please see "-Risk Factors", "Item 5-Operating and Financial Review and Prospects" and "Item 11-Quantitative and Qualitative Disclosures about Market Risk".
DIVIDENDS
Schering AG has paid the following cash dividends in respect of its ordinary shares for the periods indicated. Euro amounts in respect of dividends are translated by the ADR depositary into U.S. dollars on the date of payment April 28, 1999 ($1.0616 per €1.00; noon buying rate); April 28, 2000 ($0.9089 per €1.00; noon buying rate); April 27, 2001 ($0.8895 per €1.00; exchange rate set by the ADR depositary); April 15, 2002 ($0.8789 per €1.00); and April 11, 2003 (1.0692 per €1.00). The translation of the proposed 2003 dividend amount into dollar, was performed using the noon buying rate for the € at December 31, 2003 ($1.2597 per €1.00).
| Year ended December 31, |
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| 2003(4) | 2002 | 2001 | 2000(3) | 1999(2) |
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| € | $ | € | $ | € | $ | € | $ | € | $ |
Total dividend(1) | 0.93 | 1.17 | 0.93 | 0.99 | 0.83 | 0.74 | 1.00 | 0.89 | 0.83 | 0.75 |
(1) Adjusted to give effect, retroactively, to Schering AG's three-for-one share split effective June 1, 2000. (2) The dividend in respect of 1999 consisted of a regular dividend of €0.50 per share and a bonus dividend of €0.33 per share. (3) The dividend in respect of 2000 consisted of a regular dividend of €0.67 per share and a bonus dividend of €0.33 per share. (4) The dividend in respect of 2003 is subject to approval at the Annual General Meeting to be held on April 16, 2004.
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Holders of ADRs on the relevant record date will be entitled to receive any dividends payable in respect of the ordinary shares underlying the ADRs, subject to the terms of the deposit agreement under which the ADRs are issued. Subject to exceptions provided in the deposit agreement, cash dividends paid in euro will be converted by the depositary to U.S. dollars and paid by the depositary to holders of ADRs, net of conversion expenses of the depositary, and in accordance with the deposit agreement. The rights of holders of ADRs with respect to any dividends or other distributions on the ordinary shares underlying the ADRs will be governed by the deposit agreement and may be different from the rights of holders of ordinary shares.
For a discussion of the material German and U.S. Federal income tax provisions regarding the taxation of dividends on the ordinary shares and the ADRs, see "Item 10-Additional Information-Taxation".
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THE Schering AG GROUP
INTRODUCTION
We are a global research-based company engaged in the discovery, development, manufacture, marketing and sale of pharmaceutical products. We presently operate nine research and development centers in Europe, the United States and Japan, produce products in over 20 facilities located in Europe, the United States, Latin America and Asia, and market and sell our products in over 100 countries worldwide. Our focussed product portfolio is comprised of products from our four core business areas:
Gynecology&Andrology, including fertility control in women and men, hormone replacement therapy in menopausal women, testosterone therapy in men and the treatment of selected gynecological and andrological diseases.
Specialized Therapeutics for selected disabling and life-threatening conditions, including multiple sclerosis and other diseases of the central nervous system and the cardiovascular system, and in the field of oncology.
Diagnostics&Radiopharmaceuticals, including contrast media for X-ray, magnetic resonance imaging (MRI) and ultrasound, innovative application technologies for contrast media, and radiopharmaceuticals for use in nuclear medicine.
Dermatology for the treatment of severe skin disorders such as eczema, mycoses, acne, rosacea, psoriasis and hemorrhoids.
Our research and development efforts are primarily concentrated on the exploitation of novel technologies for unmet medical needs in our four core business areas. During 2003 and 2002, our research and development expenditures totaled €924m (19% of our total net sales) and €947m (19%), respectively.
As a global pharmaceutical company with extensive worldwide operations, we manage our businesses on a geographic basis. Our pharmaceutical business consists of five geographic reporting segments: Europe, the United States, Latin America/Canada, Japan and Asia/Middle East. Other Activities (mainly our pharmaceutical chemicals business) are managed on a worldwide basis and are therefore presented as a separate segment.
For the year ended December 31, 2003, we had net sales of €4,828m, operating profit of €686m, and net profit of €443m.
The Group is comprised of over 140 subsidiaries worldwide and had a workforce of over 26,000 employees at the end of December 2003.
Schering Aktiengesellschaft is incorporated as a stock corporation under the laws of the Federal Republic of Germany. Schering AG was incorporated in 1871. Schering AG's principal executive office is at Muellerstrasse 178, 13353 Berlin, Federal Republic of Germany, and its telephone number is (49 30) 468-1111.
STRATEGY
We are committed to expanding our pharmaceuticals business by seeking market leadership with innovative products in specialized areas
Our core mission is to make a recognized contribution to medical progress and to improve the quality of life of those who use or benefit from our products. We have established a leading market position in fertility control, multiple sclerosis, and in-vivo diagnostics and aim at leadership in hormone therapy and oncology. Sales growth over the next several years is expected to be largely driven by our successful existing products and recently launched products as well as life cycle management of our existing products. In the longer term, we intend to defend and build upon our market position in our core business areas by commercializing and marketing novel products from our rich research and development pipeline.
We are committed to the creation of shareholder value. We believe that the keys to building shareholder value are demonstrable profitable growth over the next several years and the longer term, measures such as share repurchases and dividend growth, and, where appropriate, value creation through strategic acquisitions and spin-offs and equity carve-outs of non-core businesses. We capitalized on our cash position with share repurchase programs in 1998, 1999, 2002 and 2003 totalling €420m. The Executive Board has authorized the repurchase of up to an additional four million shares during 2004. We were the first DAX-quoted company to establish such a program. Dividend growth, management's focus on constant earnings growth, and the use of stock-based compensation programs to align the interests of our employees and shareholder s emphasize our commitment.
Growth strategy
We are pursuing growth in all major pharmaceutical markets. We are focussing our efforts increasingly on our key business areas such as fertility control, specialized therapeutics, oncology and diagnostics. Our growth strategy is based on achieving the following objectives:
Consolidate our leadership position in gynecology and andrology
We intend to consolidate our leadership position in gynecology and andrology. We are the world market leader in oral contraceptives in volume terms and number two in value terms. We expect additional growth momentum from further penetration of the United States, European as well as Japanese markets. We believe that we have the broadest pipeline in fertility control and hormone therapy with a number of exciting late-stage development products and recently launched products. The most prominent of these are the oral contraceptives Yasmin® and Valette® and the intrauterine hormone delivery system Mirena®. Furthermore we are engaged in research and development into innovative female and male fertility control technologies. The future key success drivers in the area of hormone therapy w ill be the Climara® family, Angeliq® and Menostar®. Schering has also included selected indications in the field of Andrology. We are investigating the field of male fertility control and we are intensifying our activities in the area of testosterone therapy for men. Furthermore, we are developing new preparations for the treatment of gynecological and andrological diseases.
Achieve significant business growth in specialized therapeutics through leading role in multiple sclerosis and hematological oncology
Specialized therapeutics has increased in importance to us in recent years. In therapeutics we are a leading company in the field of multiple sclerosis (MS) with our product Betaferon®/Betaseron® and we are aiming to develop this indication area further through new ways of treatment. Betaferon®/Betaseron® was the first therapy to offer more than just symptom relief; it suppresses disease activity in patients with relapsing-remitting MS. It reduces the relapse rate by one third, and severe and moderate relapses are reduced by 50%. A new pre-filled diluent syringe has been launched in Europe and Japan in 2003 and will be launched in the U.S. in 2004. Designed with patient comfort in mind, the new innovation shortens preparation time, helping to simplify injections. T his adds another level of convenience for Betaferon®/Betaseron® users. We are stepping up life-cycle activities and marketing efforts on Betaferon®/Betaseron®, and developing alternative treatment options and application methods.
We also aim to achieve growth with our products in the field of oncology as well as in specialized fields for cardiovascular diseases. In oncology we are developing a leading position in hematology and a significant presence in the field of solid tumors. In collaboration with Novartis International AG we are developing an anti-angiogenic compound, PTK/ZK, which stops blood vessels from branching off to supply tumor tissue. Leukine®, an infection-fighting, white-blood cell stimulant, which is used in hematological oncology, provides additional growth opportunities through a development project for the use in Crohn's disease, which could have significant market potential. We are also focussing on the research and development of angiogenic gene therapy products based on a technology platform that includes a portfolio of therapeutic genes, vectors and proprietary methods of gene therapy to enhance cardiac function.
Expand our business basis in diagnostics and radiopharmaceuticals
In our diagnostics and radiopharmaceuticals business, we are a global leader in the X-ray contrast media and MRI contrast media fields. We aim to increase sales of contrast media for MRI and to secure our X-ray business. In the X-ray contrast media market, we are a leading company worldwide in terms of distributor sales. In the MRI contrast media market, we have a significant global market share. We aim to sustain this leadership and to continue growth through pipeline products for new applications of MRI contrast media. We also aim to extend the use of already existing contrast media by obtaining approval for additional indications, as with Gadovist® 1.0 which in November 2003 received EU approval for the use in magnetic resonance angiography (MRA). In addition to imaging agents, we develop, manufacture and market injecti on systems and disposable products through our U.S. subsidiary Medrad, Inc., which is a worldwide market leader in vascular injection systems for the application of contrast media in computed tomography (CT), angiography and MRI.
In the medium to long term, we believe that a significant growth opportunity exists in the area of innovative radiopharmaceuticals for nuclear medicine. We are developing this business through in-house research and development as well as in-licensing. The area of oncological radiopharmaceuticals presents a particularly attractive opportunity given our existing expertise in oncology and the potential for synergies between our diagnostics and therapeutics businesses.
Developing our business in the United States into a growth engine
As the world's largest and one of the fastest growing markets, the United States is a high strategic priority for us. The United States is the only market that offers pricing flexibility, broader marketing opportunities such as direct-to-consumer advertising, and a business environment that nurtures pharmaceutical innovation. We expect this growth to be achieved through increasing our presence in the areas of fertility control, hormone therapy, contrast media, oncology, dermatology as well as in the area of vascular injection systems for the application of contrast media. It is our goal to significantly expand our presence and business in the United States female healthcare market. In dermatology we hope to build up a considerable market presence.
Broaden our business in Japan
In Japan, where we have been traditionally strong in diagnostics, we are building a basis for sales growth in other business areas. Our future business expansion plans in Japan, the second-largest individual pharmaceutical market in the world, center on broadening our portfolio in the areas of specialized therapeutics and female healthcare. We have established a leading market position in the Japanese oral contraceptive market. In the next years we expect to introduce Mirena®. It is our aim to attain market leadership in female healthcare. In X-ray and MRI, we seek to remain a market leader. We will introduce further indications in MRI. In therapeutics, we created a new market through the launch of Betaferon® for the treatment of multiple sclerosis (MS). We are also establishing a position in hem atological oncology with Fludara® and strive to gain a strong position in solid tumors.
Grow the dermatology business
We continue to grow our dermatology business by expanding our portfolio in the core segments eczema, acne and psoriasis. We intend to achieve a substantial improvement in our share of the world market with products both from our internal research and development efforts and from the innovative technologies we acquire. We intensified our research, development and commercialization efforts with a particular focus on the United States dermatology market. In 2003, we established a dermatologic research center within one of the world‘s leading research areas of biotechnology – the Bay Area of San Francisco. This site in the United States is our second dermatology research location in addition to our research center in Berlin, Germany.
Long term growth through internal discovery and collaboration efforts
The foundation of our long term growth is to continue our strong emphasis on research and development, with a special emphasis on reducing the time from discovery to product launch. We intend to defend and build upon our market position in our core business areas by commercializing and marketing novel products that benefit from advances in biotechnology and molecular science discovered and developed through our internal efforts and our network of collaboration partners or obtained through in-licensing or acquisitions. We invest approximately 19% of our net sales in research and development activities. We complement our internal research and development efforts presently being carried out by over 4,500 employees at nine research and development centers with a network of collaboration arrangements.
One of our strategic objectives in research and development is to build a strong and competitive global position in oncology, where we are focusing both on hematological oncology and on novel technologies for the treatment of solid tumors. Our research, development and collaboration efforts in this field are concentrated in the area of biotechnology, including anti-angiogenesis, gene discovery and new tumor markers. To respond to the challenges of modern drug discovery such as effective research informatics and a growing pressure to deliver drug candidates in the development pipeline, we are globalizing discovery and making better use of organizational synergies. This will provide us with our own proprietary drugs, enabling us to position these products in a meaningful way in line with our regional and business area strategies. To operationalize these goals, we have integrated our worldwide research activities into a Corporate Research business area. This business area ensures the effective utilization of state-of-the-art technology platforms thereby contributing to an efficient and high-quality drug discovery process. Research informatics have been given particular emphasis as a strategically important capability for drug discovery.
There can be no assurance that we will be successful in implementing our strategy or achieving some or all of our strategic objectives.
Competitive Strengths
We believe that our competitive strengths include the following:
Focused product portfolio and research and development efforts. Our product portfolio and research and development efforts are focused on specialized areas. We have established a leading market position in fertility control, multiple sclerosis, and in-vivo diagnostics and aim at leadership in hormone therapy and hematological oncology. We believe that this specialization results in a more efficient utilization of our resources dedicated to research and development. Our technological expertise and reputation for high quality products and customer service in these areas assist us in our efforts to establish and defend leading market positions around the world.
Strong position in female healthcare. A commitment to female healthcare is one of our traditional strengths. Our female healthcare business, which is concentrated in the areas of hormonal contraception, hormone therapy and gynecological therapy, is designed to meet the lifetime needs of women. We are presently one of the remaining major global players in this area.
Competence in commercializing and marketing new technologies and products. We have a demonstrated competence in identifying, commercializing and marketing new technologies and products first developed by niche companies in the pharmaceutical and biotechnology industries. This ability will become increasingly important as the cost of developing new drugs continues to increase and a premium is placed on the speed of bringing new products to market.
Leadership in diagnostics. We continue to be a global leader in the discovery, development and marketing of in-vivo diagnostic products. We believe that we are the leading company worldwide in terms of distributor sales and market share in X-ray and MRI contrast media products. Our discovery efforts in diagnostics also distinguish us from our competitors. We believe our entry into radiopharmaceuticals will both benefit from and contribute to our competence in diagnostics.
High quality sales and marketing force and proprietary distribution network. We have a worldwide sales force of over 8,500 representatives. We appreciate that a commitment to the initial and continuing training and retention of our sales force is an important competitive factor. Our representatives are dedicated exclusively to the marketing of our products and we believe they enjoy an excellent reputation for their specialized knowledge of our products and therapies and their dedication to customer service. We believe this contributes to our objective of providing a superior level of customer service.
History
We have been engaged in the pharmaceuticals business for over 130 years. Our founder, Ernst Schering, established a pharmacy in Berlin, Germany, in 1851, and on October 23, 1871, formed our predecessor company under the name "Chemische Fabrik auf Actien (vorm. E. Schering)". During the course and in the aftermath of World War II, substantially all of Schering AG's subsidiaries, patents, trademarks and other properties located outside of Germany were liquidated, confiscated or expropriated. Following the entry of the United States in World War II, the United States government confiscated the assets of German companies in the United States, including Schering AG's subsidiary Schering Corporation. This subsidiary was operated by a guardian appointed by the United States government for the next decade and, in 1952, was di vested by the United States government to an investment group. Following a merger, the company became known as Schering-Plough Corporation in 1971. Schering AG and Schering-Plough Corporation have been totally independent of each other for many years, and have an agreement relating to the use of the word "Schering". See "-Patents and Other Intellectual Property" for a description of this agreement. Schering AG operates its pharmaceutical business in the United States and Canada under the Berlex trade name.
The Schering AG Group significantly restructured its operations over the past decade to concentrate on its pharmaceutical business. During the last seven years, we have expanded our pharmaceutical product portfolio and obtained promising new technologies through a number of small- to mid-sized acquisitions and licensing as well as research and development collaboration relationships. Significant acquisitions during this period include:
in our Gynecology&Andrology business area, our 1996 acquisitions of Leiras Oy (merged in our finnish subsidiary Schering Oy as of March 2003) and a majority share of Jenapharm GmbH & Co. KG, which became a wholly-owned subsidiary in 2001.
in the area of Specialized Therapeutics, our acquisition in March 2000 of the Japanese company Mitsui Pharmaceuticals, Inc. (merged in our Japanese subsidiary Nihon Schering K.K. as of January 1, 2001) and our acquisition in July 2002 of Collateral Therapeutics, Inc. as well as the acquisition of the rights in Leukine® from Immunex Corporation.
in our Diagnostics&Radiopharmaceuticals business area, our acquisition in 1995 of Medrad, Inc., our acquisitions in November 1999 of Diatide, Inc. (merged in our U.S.-subsidiary Berlex Laboratories, Inc. as of February 1, 2001), in April 2000/December 2001 of CIS bio international S.A. and in July 2002 of MAP Medical Technologies Oy.
For a description of certain of our more significant licensing and collaboration relationships, see "-Products" and "-Research and Development-Collaboration Efforts".
PRODUCTS
Our product portfolio is comprised of products from our core business areas of Gynecology&Andrology, Specialized Therapeutics, Diagnostics&Radiopharmaceuticals and Dermatology. For a discussion of certain products and processes which we are currently developing, see "-Research and Development".
In addition to net sales of products from our four core business areas, we derive net sales from certain other sources comprised of third party businesses (sales cooperations and toll manufacturing principally of pharmaceutical chemicals for third-parties) and curtailments of sales (granted bonuses, sales discounts and cash discounts). These net sales are referred to as net sales from "Other Sources" in this annual report.
Gynecology&Andrology
The following table sets forth selected Gynecology&Andrology products presently marketed by the Group.
| | | Net sales |
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Product | Active ingredient(s) | Indication | 2003 | 2002 |
---|
| | | (€million) |
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Yasmin® | Drospirenone/ethinylestradiol | Combined oral contraceptive | 290 | 152 |
Diane® | Cyproterone acetate/ ethinylestradiol | Androgen dependent disorders in women (including acne, seborrhea, hirsutism) | 202 | 226 |
Mirena® | Levonorgestrel | Intrauterine hormonal contraceptive | 164 | 137 |
Microgynon®/Levlen® | Levonorgestrel/ ethinylestradiol | Combined oral contraceptive | 122 | 130 |
Meliane® | Gestodene/low dose ethinylestradiol | Combined oral contraceptive | 119 | 127 |
Femovan® | Gestodene/ethinylestradiol | Combined oral contraceptive | 84 | 97 |
Climara® | Estradiol | Hormone therapy (patch) | 69 | 92 |
Triquilar®/ Tri-Levlen® | Low-dose levonorgestrel/ethinylestradiol | Combined oral contraceptive (triphasic) | 61 | 75 |
Valette® | Low-dose dienogest | Monophasic oral contraceptive | 47 | 40 |
Miranova®/ Levlite® | Low-dose levonorgestrel/low-dose ethinylestradiol | Combined oral contraceptive | 31 | 45 |
Climen® | Estradiol valerate/cyproterone acetate | Hormone therapy (oral) | 27 | 36 |
Our comprehensive female healthcare program develops preparations in the areas of fertility control, hormone therapy and gynecological therapy.
In our male healthcare program, we are engaging in the research and development of products for male fertility control, age-related diseases and sexual disorders. Products for the treatment of hypogonadism (suppressed function of the testes with reduced testosterone production) are part of the Group's range of healthcare products for men.
Fertility control
Over the past four decades, we have continuously improved the tolerability and safety of oral contraceptives by reducing the hormone dosage and developing new gestagens and treatment regimen. Today, we are marketing a variety of hormonal contraceptives in order to meet the various needs of women. The Group's fertility control products are comprised of oral contraceptives and a number of alternatives to oral contraception, including intrauterine hormone delivery systems, hormonal injections and contraceptive implants.
Oral contraceptives
In general, oral contraceptives can be divided according to their composition into combined preparations and gestagen-only preparations (minipills).
Combined oral contraceptives contain an estrogen component, usually ethinylestradiol, and a gestagen component. Over the years, the estrogen content has been gradually reduced. The standard dose today is 0.03 mg ethinylestradiol per day. With Miranova® and Meliane®, Schering AG offers oral contraceptives with an ethinylestradiol dose as low as 0.02 mg per day. Schering AG's contraceptive Mirelle® contains only 0.015 mg ethinylestradiol.
The dose of individual gestagens in oral contraceptives has also been reduced over time. More importantly, new gestagens with higher potency and more favorable pharmacological properties have been discovered and developed. Schering AG's new gestagens dienogest and drospirenone have not only a contraceptive effect but provide additional therapeutic benefits.The minipill (gestagen only pill) is an alternative for women with estrogen intolerance who want to have the advantages of oral contraception. Combined oral contraceptives generally can be subdivided into monophasic, biphasic and triphasic preparations. Monophasic preparations contain a dosage of an estrogen and a gestagen which is the same over the whole treatment cycle. In biphasic preparations, the daily dose of gestagen is increased in the second half of the cycle of use, while the estrogen dose remains constant over the entire cycle of use. Triphasics contain graduated daily dose levels of hormones in order to mimic the variable hormone production of the physiological cycle while keeping the total dosage of exogenous steroids as low as possible.
Our portfolio of oral contraceptives includes:
Yasmin®. Yasmin® is an oral contraceptive with the innovative gestagen drospirenone. High contraceptive reliability and excellent cycle control are basic clinical features of this preparation. The anti-mineralocorticoid activity of drospirenone counterbalances potential estrogen-induced fluid retention. Yasmin® could be particularly suitable for women susceptible to estrogen-related water retention. Clinical studies have shown that Yasmin® can improve the general well-being of women and has positive effects on symptoms of premenstrual syndrome (PMS). Due to drospirenone's anti-androgenetic properties, positive effects on mild to moderate acne and seborrhea were also observed. Yasmin® has been shown to be well-tolerated, with a low incidence of adverse events. In 2001, Yasmin® was launched in the United States as well as in a number of European countries. At the end of 2003, Yasmin® was marketed in more than 40 countries worldwide.
Microgynon® (marketed in the United States as Levlen®). Microgynon® is a monophasic oral contraceptive containing levonorgestrel and is available in the United States, Europe, Latin America and Asia.
Femovan®. Femovan® is a monophasic oral contraceptive containing gestodene. The product shows an excellent tolerability, contraceptive reliability and cycle control. Femovan® was first launched in 1987 and is available in Europe, Latin America and Asia.
Triquilar® (marketed in the United States as Tri-Levlen®). Triquilar® is an oral contraceptive containing levonorgestrel in a triphasic dosage regime, mimicking the variable hormone production of the menstrual cycle while keeping the total dose of exogenous steroids as low as possible. Triquilar® was first launched in 1979 and is available in Europe, Latin America, Asia, the United States and, since 1999, in Japan.
Meliane®. Meliane® is a low-dose monophasic oral contraceptive containing gestodene. The product exhibits high contraceptive reliability, cycle control and tolerability. Meliane® was first launched in France in 1995 and is available in Europe, Latin America and Asia.
Valette®. Valette® is a low-dose monophasic oral contraceptive containing dienogest. Valette® demonstrates high contraceptive reliability, excellent tolerability and a stabilizing effect on irregular menstrual periods. The anti-androgenic activity of dienogest has beneficial effects on acne and seborrhea. Valette® was first launched in Germany in 1995. Today, Valette® is available in many European countries. Further launches throughout Europe are expected within the next few years.
Miranova® (marketed in the United States as Levlite®). Miranova® is a low-dose monophasic oral contraceptive containing levonorgestrel. In addition to high contraceptive reliability, Miranova® provides good cycle control with a low frequency of inter-menstrual bleedings and a low incidence of side effects. Miranova® was launched in Germany in 1996 while Levlite® was launched in the United States in 1998.
Non-oral contraceptives
Mirena®, an intrauterine gestagen-containing delivery system, is a non-oral alternative in family planning, and one of our fastest growing products as measured by net sales. Mirena® combines the advantages of local hormonal and intrauterine contraception. Mirena® is inserted into the uterus, where it releases low doses of levonorgestrel for a period of five years. Due to its anti-proliferative effect on the endometrium, Mirena® also leads to a significant reduction in both the amount and duration of menstrual bleeding. Therefore, Mirena® is increasingly recognized as the therapy of choice in cases of abnormally heavy and prolonged menstruation. Mirena® was first launched in Europe in 1990. It is also available in Asia and Latin Ameri ca. Mirena® was launched in the United States in 2001.
Hormonal contraception can also be achieved using intra-muscular injections, which ensure a long-lasting effect. Our injectable contraceptive Norigynon® (Mesigyna®) contains an estrogen and gestagen derivative and is injected once a month, while Noristerat® relies on a gestagen-only effect and is administered once every three months.
We also offer levonorgestrel-containing contraceptive implants. These implants are placed under the skin where they release low doses of hormone for 5 years.
Hormone therapy in menopausal women
Approximately 50% of menopausal women suffer from climacteric symptoms which require treatment and can be attributed to the cessation of sex hormone production by the ovaries during perimenopause. The loss of ovarian hormones results not only in climacteric complaints such as hot flashes, but also in a higher risk of osteoporosis (loss of bone mass). This disorder can be prevented by supplementation of the hormones that the body has ceased to produce in sufficient amounts.
Preparations consist of either estrogen alone for hysterectomized women, or an estrogen-gestagen-combination for those with intact uteri. The hormone combination can be used as a sequential or a continuous method. In the sequential regimen, which is the method mainly used during pre- and perimenopause, the gestagen is added to the estrogen only in the second half of the cycle. The advantage of the sequential method is that the gestagen counteracts growth of the uterine lining that may result from estrogen use and stabilizes the unwanted irregular cycles in pre-menopause and post-menopause. The cyclical use of a gestagen leads to withdrawal of bleeding.
In continuous combined regimen, which is used for postmenopausal women, both the estrogen component and the gestagen are administered simultaneously over the entire period of use. The advantage of this regimen is that no cyclical bleeding is induced and amenorrhea can be achieved. The goal of continuous combined regimen for postmenopausal women is to relieve climacteric symptoms, such as hot flashes and to address other age- and hormone-related disorders, such as osteoporosis.
We believe that net sales in this business field were adversely affected by the controversial scientific discussion about the benefits and risks of hormone therapy. However, we remain committed to this business field because of the undisputable medical need for hormone therapy in menopausal women.
Our portfolio of hormone therapy products offers therapy for the needs of women in all phases of the climacterium.
Climen®. Climen® is a sequentially combined oral preparation. It contains estradiol valerate and cyproterone acetate. Climen® effectively reduces climacteric complaints and prevents postmenopausal osteoporosis. In addition, Climen® has a positive influence on androgen-related skin disorders like acne, seborrhea and androgenic hair loss.
Climara®. Climara® is an alternative to oral estrogen therapy. Climara® is a once-a-week patch which releases estradiol. Climara® reduces climacteric symptoms effectively. Climara® was first launched in the United States in 1995. In 1999, Climara® received FDA approval for the prevention of osteoporosis. Climara® is available worldwide.
Climara Pro™. As an alternative to oral continuous combined therapy, Climara Pro™ is a combination patch with estradiol and levonorgestrel. This patch only needs to be renewed once a week and is intended for the treatment of menopausal symptoms. The product was approved in the United States in November 2003.
Climodien®. Climodien® contains estradiol valerate combined with dienogest in a continuously combined regimen for oral treatment of climacteric symptoms. No cyclical bleeding is induced in the majority of users, thus providing a therapeutic option for women not wishing to return to regular menstrual bleeding. Containing an antiandrogenic gestagen, Climodien® has an excellent profile with regard to relief of menopausal symptoms. Climodien® was first launched in Germany in 2001. It was launched in several of European countries, including France, Spain, Portugal, Belgium, Netherlands, Luxembourg and Russia. A variation of Climodien® with a lower estrogen dose is being developed. The two preparations will provide women with an option of individualized estrogen doses acc ording to the women's needs without changing the gestagen component. The lower-dose Climodien® was submitted in Europe in 2003.
Avaden®. Avaden® is our new oral gestodene-containing sequentially combined product. Two dosage strengths are provided in the estrogen treatment, thus allowing adjustment according to individual needs (Avaden® 1 and Avaden® 2). Avaden® is effective in the treatment of climacteric symptoms and osteoporosis prevention. Avaden® induces a favorable bleeding pattern with predictable and regular cyclical withdrawal bleeding. Avaden® was launched in 2003 in France. Further launches, especially in Europe and Latin America, are planned for 2004.
Angeliq®. Angeliq® is a continuous combined oral preparation, containing estradiol and drospirenone, a unique gestagen component. The gestagen drospirenone has an anti-aldosterone activity, which provides benefits, avoiding fluid retention and subsequent weight increase. Angeliq® has shown to be effective in the treatment of climacteric symptoms and the prevention of osteoporosis. Furthermore, most recent clinical data have shown positive effects of Angeliq® on blood pressure in mildly hypertensive women. The product received marketing authorization in the Netherlands in December 2002, and has been on the market since September 2003. Based on the approval in the Netherlands, which is the European Reference Member State for the Mutual Recognition Procedure, marketing authoriz ation of Angeliq® in the EU was granted in July 2003. The product has also been submitted for registration in the United States. Although the approval of the product was initially refused in the U.S., we are currently undertaking all the necessary measures to ensure that approval will be granted.
Gynecological therapy
We offer a range of products for the treatment of certain hormone-related gynecological disorders, including Diane®, Androcur® and Progynon® C. Diane® is labeled for the treatment of acne but exerts the same contraceptive reliability as combined oral contraceptives. Androcur® is an anti-androgen used, in certain cases in combination with Diane®, for the treatment of hirsutism (symptoms of masculine hair growth in women), acne and seborrhea caused by increased androgen levels. Progynon® C is an estrogen for the treatment of primary and secondary amenorrhea.
Male healthcare
Our male healthcare program includes products for the treatment of male hypogonadism (testosterone deficiency):
Testoviron®-Depot 250. Testoviron®-Depot 250 contains testosterone enanthate (TE) in an oily formulation for injection every two to four weeks for the treatment of hypogonadism (underfunction of the testes with reduced testosterone production). TE is a testosterone ester which after injection is quickly broken down to release the active ingredient testosterone.
Proviron®. Proviron® is an orally active androgen containing mesterolone with good liver tolerance for the treatment of hypogonadism.
Testogel®. Testogel® is a transdermal gel formulation containing native testosterone for daily application. In 2003, we launched Testogel® in the majority of European countries including Germany, Austria, Finland, United Kingdom and Portugal. The rollout process will continue in 2004. Testogel® was licensed from Besins International in 2002 for the markets of the European Union (excluding France), Switzerland, Australia,Turkey and New Zealand.
Nebido™ (testosterone undecanoate). In November 2003, we received a registration in Finland for Nebido™, the first long-acting testosterone injection. It has two major advantages compared to previously available preparations. Firstly, the release pattern is well controlled so that the blood concentrations will stay within the desired physiological range. Secondly, the duration of action could be extended considerably. Nebido™ needs to be injected only four times per year instead of approximately 20 injections of testosterone enanthate, the current standard therapy. We intend to obtain registration for Nebido™ in other European countries. Nebido™ will be launched in Europe in the second half of 2004.
We have also developed cyproterone acetate (Androcur®) – the first anti-androgen for the treatment of inoperable prostatic carcinoma.
Specialized Therapeutics
The following table sets forth selected therapeutic products presently marketed by the Group.
| | | Net sales |
---|
Product | Active ingredient(s) | Indication | 2003 | 2002 |
---|
| | | (€million) |
---|
Betaferon®/Betaseron® | Interferon b-1b | Multiple sclerosis (for relapsing-remitting and secondary progressive forms in Europe, Australia and Canada; for relapsing forms of MS in the U.S.) | 770 | 783 |
Fludara® | Fludarabine phosphate | Chronic lymphocytic leukemia | 140 | 149 |
Androcur® | Cyproterone acetate | Prostate cancer | 93 | 95 |
Leukine® | Sargramostim | Hematological oncology | 64 | 33 |
Campath®/ MabCampath® | Alemtuzumab | Chronic lymphocytic leukemia | 63 | 46 |
Ilomedin® | Iloprost | Peripheral Arterial Occlusive Disease (PAOD) stages III/IV | 47 | 47 |
Noctamid® | Lormetazepam | Sleep disturbances | 44 | 47 |
Ventavis® | Iloprost | Primary pulmonary hypertension | * | – |
* Product launched in 2003
|
We develop novel therapeutics and offer innovative products for the treatment of selected disabling and life threatening conditions, including multiple sclerosis and other diseases of the central nervous system and cardiovascular system, and in the field of oncology.
Central nervous system
Our portfolio of therapeutic products for the treatment of diseases of the central nervous system includes Betaferon®/Betaseron® and Noctamid®.
Betaferon® (interferon ß-1b). Betaferon® (which is marketed in the United States and Canada under the trademark Betaseron®) has been the Group's leading product in terms of net sales for the past five years. Betaferon® was the first beta interferon developed for the treatment of multiple sclerosis (MS). The product was approved for relapsing remitting MS in the United States in 1993, in Europe in 1996 and was approved in Japan in September 2000. Betaferon® is also marketed in all major Latin American markets. Betaferon® was approved for the treatment of secondary progressive MS in Europe, Australia and Canada in 1999. In 2003 the FDA expanded Betaferon’s indication for the United States to treat all relapsing forms of MS to reduc e the frequency of clinical exacerbations. Relapsing forms of MS include relapsing-remitting MS, the most common form and secondary progressive MS with relapses. A new room-temperature stable formulation of Betaferon® was approved in the United States in January 2002 and was launched in May 2002. In Europe the authorities have approved the room-temperature stable storage of Betaferon® by the patient for a period of up to three months. The room-temperature stable formulation of Betaferon® provides a convenient option for MS patients. A new pre-filled diluent syringe has been launched in Europe and Japan in 2003 and has been launched in the United States in 2004. This latest innovation further improves the convenience for patients using Betaferon®. Betaferon® is manufactured for the markets in North America, Japan and certain other countries by Chiron Corporation. In Europe, Betaferon® is manufactured by Boehringer Ingelheim.
Noctamid® (lormetazepam). Noctamid® is a short-acting benzodiazepine which has been developed and marketed for the treatment of sleep disorders.
Cardiovascular system
Our portfolio of therapeutic products for the treatment of diseases of the cardiovascular system includes Ilomedin® and Ventavis®.
Ilomedin® (iloprost). Ilomedin® is a stable prostacyclin analogue used for the intravenous treatment of severe forms of peripheral arterial disease (peripheral arterial occlusive disease (PAOD) stages III and IV) and thrombo-angiitis obliterans. The product increases the microcirculatory perfusion and has been shown to reduce rest pain, improve ulcer healing and reduce the need for amputation. Ilomedin®, which was first launched in 1992, is marketed in all major European markets and several additional countries including New Zealand.
Ventavis® (iloprost). Ventavis® contains iloprost as the active ingredient and is an inhalation treatment for patients with primary pulmonary hypertenstion, a disease with a high need for an acute and effective treatment. Ventavis® is the only prostacyclin product that targets the pulmonary vessels more directly by inhalation. Ventavis® has been approved by the European Commission in 2003 and is marketed in Europe. We have entered into an agreement with CoTherix, Inc for the U.S. development and marketing of the product.
Oncology
We presently market five therapeutic products in the area of oncology: Androcur®, Leukine®, Fludara®, Bonefos® and Campath®/MabCampath®. In addition, we have recently obtained rights to a number of promising products and processes in the area of oncology, as discussed under "Research and Development-Specialized Therapeutics".
Androcur® (cyproterone acetate). Androcur® is an anti-androgen used for the palliative treatment of advanced prostate cancer. Androcur® reduces testosterone serum levels and blocks androgen receptors mediating cancer growth. The drug combines gestagenic and anti-androgenic activities.
Leukine® (sargramostim). Leukine® is an infection-fighting, white-blood cell stimulant based on a granulocyte-macrophage colony-stimulating factor (GM-CSF), which is used in hematological oncology. Leukine® is the only CSF indicated for use following induction chemotherapy in older adults with acute myelogenous leukemia to shorten time to neutrophil recovery and reduce the incidence of severe and life-threatening infections as well as infections resulting in death. Additional indications include the use of Leukine® in myeloid reconstitution following allogeneic and autologous bone marrow transplantation (BMT), for peripheral blood stem cell (PBSC) mobilization and subsequent myeloid reconstitution in patients undergoing PBSC transplantation, and in bone marrow transpl antation or engraftment delay. Leukine® was first approved in 1991.
Fludara® (fludarabine phosphate). Fludara® is currently marketed in the field of hematological oncology. Fludara®, which was launched in the United States in 1991 and in Europe in 1994, is also marketed in all major Latin American markets and in Japan. It is a purine analogue acting as an anti-metabolite and has been approved for the treatment of patients with relapsed or refractory chronic lymphocytic leukemia (CLL). Due to high response rates and a significant proportion of complete remissions, Fludara® has been established as a standard treatment for this group of patients. The drug is approved as second and third-line monotherapy for CLL and was approved for first-line therapy in 2003. An oral formulation of Fludara® has been approved in all of Europe exc ept Germany, Belgium and Portugal. It is also approved in 16 additional countries including Canada and Australia. Patent protection for Fludara® in the United States expired in 2003, and we expect a decrease in sales due to competition from generic products.
Bonefos® (clodronate). Bonefos® is a second generation bisphosphonate for the treatment of hypercalcemia and osteolysis due to malignancies. The product is available as an intravenous or an oral formulation. We market Bonefos® in several countries in Europe, the Middle East and Asia. We plan to file for approval in the U.S. during 2004 for the prevention of bone metastisis indication in early stage breast cancer.
Campath®/MabCampath®(alemtuzumab). Campath® is the first and only monoclonal antibody approved for treatment of chronic lymphocytic leukemia (B-CLL). It represents the first specific therapy indicated for CLL patients refractory (not responding) to Fludara® treatment. The mechanism of action of this biologic is the binding to the CD52 antigen of the surface of B-cells. By binding and the activation of the complement system, the B-cells are killed. Clinical development has been completed in patients who previously received alkylating agents and failed Fludara® therapy. Campath® has been launched in the United States and Europe (trademark in Europe: MabCampath®). In June 2003, the European Committee for Proprietary Medicin al Products (CPMP) has granted a positive opinion on the addition of survival data to the label for the drug. After recently acquiring the rights for Japan, China and the Asian-Pacific Basin we now have worldwide marketing rights to Campath® under a distribution and development agreement with ILEX Oncology, Inc. As a line extension, a clinical phase III study in first-line CLL is ongoing.
Zevalin®. In addition to our Fludara® line extensions and Campath® within the field of hematological oncology, our primary development efforts in the field of hematological oncology is Zevalin®. Zevalin® is an yttrium-labeled monoclonal antibody targeting the CD20 antigen and is being developed as radioimmunotherapy of relapsed, refractory low-grade non-Hodgkin's lymphoma (NHL). The mechanism of action is ß-radiation by yttrium-90, which is linked to the antibody. The antibody carries the radioactivity to the tumor sites by binding to the CD20 antigen of B-cells. Prior to Zevalin® therapy, peripheral B-cells need to be cleared by a low do se of rituximab (produced by Genentech/La Roche). Zevalin® shows significantly higher clinical efficacy compared to non-radioactive anti-CD20 monoclonal antibodies and also for patients refractory to rituximab. In February 2002, the FDA has approved Zevalin® for follicular, B-cell low-grade NHL patients no longer responding to rituximab. In January 2004, we received approval to launch Zevalin® in the EU. It is the first radioimmunotherapy approved in the United States and Europe. The Group has worldwide rights to Zevalin®, excluding the United States.
Diagnostics&Radiopharmaceuticals
The following table sets forth selected products from our Diagnostics&Radiopharmaceuticals business area presently marketed by the Group.
| | | Net sales |
---|
Product | Active ingredient(s) | Indication/description | 2003 | 2002 |
---|
| | | (€million) |
---|
Magnevist® | Gadopentetate dimeglumine | MRI contrast medium | 300 | 322 |
Iopamiron® | Iopamidol | X-ray contrast medium | 263 | 299 |
Ultravist® | Iopromide | X-ray contrast medium | 236 | 241 |
We are focused on the research, development and commercialization of imaging agents for the diagnosis of diseases and disorders. The Group's principal products in the Diagnostics&Radiopharmaceuticals business area include contrast media for use in X-ray, magnetic resonance imaging (MRI), radiopharmaceuticals for use in nuclear medicine as well as contrast medium application technologies.
We have engaged in the research and development of contrast agents for over 70 years. Contrast media are used by radiologists, cardiologists and other physicians to improve the outcomes of diagnostic imaging procedures. The contrast agent is generally administered to the patient by injection.
In addition to imaging agents, we develop, manufacture and market injection systems and disposable products through our U.S. subsidiary Medrad, Inc. We acquired Medrad in 1995 to enhance and strengthen the Group's expertise and capabilities with regard to contrast media application and other imaging related technologies. Medrad is a worldwide market leader in vascular injection systems for the application of contrast media in computed tomography (CT), angiography and MRI.
X-ray contrast media
Iopamiron® (iopamidol). Iopamiron® is an extracellular non-ionic monomeric X-ray contrast medium primarily for intravascular use. We distribute Iopamiron® in Japan, France and Latin America under a license from Bracco S.p.A.
Ultravist® (iopromide). Ultravist® is an extracellular non-ionic monomeric X-ray contrast medium for intravascular use.
MRI contrast media
Magnevist® (gadopentetate dimeglumine). Magnevist® is an extracellular MRI contrast agent for cranial, spinal and body applications for patients of all age groups. The product was the first MRI contrast agent marketed.
Gadovist® 1.0 (gadobutrol). Gadovist® 1.0 is an extracellular MRI contrast agent. In November 2003, Gadovist® 1.0 was approved in Europe in the indication magnetic resonance angiography. Gadovist® 1.0 is also being developed for body indications and is currently in phase III clinical studies. Gadovist® 1.0 is particularly suited for such applications as perfusion imaging and high-dose studies.
Resovist® (ferucarbotran). Resovist® is an MRI contrast agent for liver-specific imaging being developed for the improved detection and characterization of hepatic tumors.
Radiopharmaceuticals for nuclear medicine
Quadramet® (Sm-153 Lexidronam injection). Quadramet® is a therapeutic agent for the relief of bone pain in patients with metastatic bone lesions that image on conventional bone scan. Quadramet® consists of a radioactive isotope, Samarium-153, which emits beta radiation, and a chelating agent, EDTMP, which targets the drug to sites of new bone formation. We market the product in Europe and are pursuing clinical development in Japan. As a result of the revision of our radiopharmaceutical strategy, we returned the U.S. marketing rights for Quadramet® to Cytogen Inc. in the summer of 2003.
Flucis® (fludeoxyglucose). Flucis® is a diagnostic agent for the expanding market segment of positron emission tomography (PET). It shows increased glucose consumption in the body and is used in a very broad spectrum of diagnostic processes such as diagnosis, staging, monitoring and the detection of recurrences of several oncologic indications including head and neck cancer, lung cancer and malignant lymphomas.
Dermatology
The following table sets forth selected dermatology products marketed by the Group.
Product | Active ingredient(s) | Indication | Net sales |
---|
| | | 2003 | 2002 |
---|
| | | (€million) |
---|
Advantan® | Methylprednisolone aceponate | Eczema | 35 | 35 |
Nerisona®/ Nerisona® C/ Tri-Nerisona® | Diflucortolone valerate/diflucortolone valerate, chlorquinaldol/diflucortolone valerate, isoconazole nitrate, neomycin sulfate | Corticoid responsive dermatoses | 31 | 35 |
Travogen®/ Travocort® | Isoconazole nitrate/difluocortolone valerate | Superficial dermatomycoses | 30 | 31 |
Skinoren®/ Finevin®/ Finacea™ | Acelaic acid cream/Acelaic acid gel | Mild to moderate acne/Rosacea | 20 | 20 |
Neriproct® | Diflucortolone valerate, lidocain | Hemorrhoids | 16 | 20 |
The Group has been engaged in the area of Dermatology since we pioneered modern dermatological therapies with topical corticoids in the early 1950s. We are currently active in several of the most important dermatological indication fields, including eczema, acne, psoriasis, mycoses, rosacea and hemorrhoids.
Our principal products in the Dermatology area are:
Advantan® (methylprednisolone aceponate). Advantan® is a topical corticosteroid for the treatment of eczema.
Nerisona® (diflucortolone valerate). Nerisona® is a corticosteroid of medium potency used for the treatment of eczema and psoriasis. The product is available as cream, ointment, fatty ointment and solution.
Travogen® (isoconazole nitrate). Travocort® (isoconazole nitrate, difluocortolone valerate). Travogen® and Travocort® are our prime anti-fungal products for the treatment of dermatomycoses. Travocort® is also indicated in super-infected dermatomycoses.
Skinoren® (azelaic acid cream). Skinoren® is used to treat mild to moderate inflammatory acne vulgaris. Skinoren® was launched in Europe in 1989 and in Latin America in 1995. We used to co-market this product in the United States as Finevin™ Cream. While we ceased marketing Finevin®, Allergan Inc. continues to market the product under the tradename Azelex®.
Neriproct® (diflucortolone valerate, lidocain). Neriproct® is used to treat hemorrhoids and is distributed in Japan.
Finacea™ (azelaic acid gel). Finacea™ is a treatment for rosacea, a common skin disease that causes redness and inflamed pustules on the face. Rosacea represents an underserved market with currently limited therapy options. In the United States it was approved for the treatment of rosacea and was launched in March 2003 in a co-promotion arrangement with Allergan Inc. In December 2003, Finacea™ received marketing approval for 15 European countries.
Psorcutan® (calcipotriol). Psorcutan® is a vitamin D3 based topical product for the treatment of mild to moderate psoriasis. The product is available as ointment, cream or solution. Psorcutan® was developed by Leo Pharma A/S, Denmark and first launched in Germany in 1992. We have semi-exclusive rights to distribute Psorcutan® in Germany, Italy, Austria and Turkey under a licensing agreement which has been prolonged in 2001 until 2012.
Psorcutan® Beta (combination calcipotriol and betamethasone diproprionate). Psorcutan® Beta is a combination of the vitamin D analogue calcipotriol and a potent corticosteroid for the treatment of mild to moderate psoriasis. The product which is formulated in an ointment base was first launched in Germany in November 2002. The semi-exclusive marketing and distribution rights for Psorcutan® Beta were acquired from LEO Pharma A/S, Denmark, for Germany, Italy, Austria and Turkey.
RESEARCH AND DEVELOPMENT
Overview
Our research and development activities are focused primarily on four selected fields with a high degree of unmet medical needs. We are concentrating on the exploitation of novel approaches resulting in the development of:
therapy of selected disabling and life threatening diseases.
sensitive and highly specific diagnostics.
gender specific health care products.
treatments of severe skin disorders.
In our drug and target discovery efforts, we are committed to the application of cutting edge technologies, including gene therapy, gene discovery, functional genetics and pharmacogenomics, state-of-the-art combinatorial chemistry and high throughput screening methods. We have instituted several programs designed to optimize the research and development process in order to shorten the period of time from the start of early compound finding until the time that the product reaches the market.
Through Corporate Research Business Areas, we advance the global responsibilities in our worldwide research organization with the aim of linking knowledge, abilities and the promotion of innovation all over the world. These functional units ensure that pharmaceutical research optimizes synergies between the scientific disciplines and technologies involved to enhance the discovery of drug development candidates. Additionally, we have Research Centers in Europe, the United States and Japan. These centers provide for state-of-the-art drug discovery technologies for our four research business areas.
Collaboration efforts
Besides our internal research and development efforts, we have made a strategic decision to engage in efficient collaborations. Thus, we continuously monitor drug and target discovery and new therapeutic principles in our four business areas and beyond for opportunities to enrich our product portfolio and to broaden our technology platform. We enter into licensing arrangements or otherwise acquire synergistic or value-added drugs and technologies. We have established a number of research and development cooperation networks with leading international academic and industrial partners, including biotechnology companies and major pharmaceutical companies.
The following table describes certain of our principal collaboration partners and collaboration objectives:
Partner | Objective |
---|
Asahi Kasei Corporation | Treatment of chronic stable angina pectoris |
Astex Technology, Ltd. | Discovery of novel drugs principally focusing on drugs targeting solid tumors |
Atugen AG | Genomics-antisense technology for target validation |
Chiron Corporation | Dosage and application of beta interferon |
EPIX Medical, Inc. | MRI contrast media |
Biogen Idec, Inc. | Radioimmunotherapy in hematological oncology (radiolabeled mAB) |
ILEX Oncology, Inc. | Immunotherapy in hematological oncology (mAB) |
INCYTE Pharmaceuticals, Inc. | Genomics-access to EST/gene database |
Medarex Inc. | Fully human monoclonal antibody technology |
MorphoSys AG | Antibody diagnostics and therapeutics for cancer and other life threatening diseases |
3M Company | Hormone therapy patches for menopausal women |
Neurosciences Victoria Ltd. | Treatment of neurodegenerative disorders |
Novartis International AG | Joint development of angiogenesis inhibitors (therapy of solid tumors) |
Peregrine Pharmaceuticals, Inc. | Selective cancer diagnostics (vascular targeting agents) |
Philogen S.r.l. | Diagnosis and therapy of solid tumors |
The Population Council | Synthetic androgen for treatment of hypogonadism |
TAP Pharmaceuticals Inc. | Asoprisnil for the treatment of fibroids |
Titan Pharmaceuticals, Inc. | Development of injectable cells producing dopamine for treatment of Parkinson's |
University of Virginia | Identification of a new target for male contraception |
Vertex Pharmaceutical (Europe) Ltd. | Development of small molecules for the treatment of neurodegenerative diseases |
Research and development efforts
Expenditures on research and development decreased by 2% to €924m in 2003 from €947m in 2002. In 2002 expenditures on research and development increased by 10% to €947m compared to €864m in 2001.
In 2003, €774m (84%) of our R&D expenses can be attributed to specific projects, and can be divided by Business Area as follows: Gynecology&Andrology 21%; Specialized Therapeutics 46%; Diagnostics&Radiopharmaceuticals 17%; Dermatology 6%. R&D expenses which cannot be allocated to specific projects primarily relate to pre-clinical research, administration, infrastructure, international project management and indirect costs incurred in order to comply with regulations for registration. The following table sets forth, by business area, the research and development expense allocable to projects for fiscal years 2003, 2002 and 2001:
Research and development expense allocable to projects by Business Area: | 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Gynecology&Andrology | 162 | 175 | 172 |
Specialized Therapeutics | 354 | 327 | 283 |
Diagnostics&Radiopharmaceuticals | 134 | 137 | 121 |
Dermatology | 48 | 57 | 36 |
Other research projects | 76 | 59 | 40 |
Total | 774 | 755 | 652 |
Gynecology&Andrology
We are a pioneer in providing healthcare solutions for women and men and our products seek to meet the highest standards of efficacy, reliability and safety. In female healthcare, we have set highest quality standards with preparations for fertility control, hormone therapy and gynecological therapy. In fertility control, our research and development efforts are aimed to identify new modes of contraception (hormonal and non-hormonal), to reduce hormone dosages further, to improve tolerability, to develop new methods for application and to offer additional therapeutic benefits. For hormone therapy, we are developing products for the treatment of climacteric complaints and for the prevention and treatment of osteoporosis with a panel of treatment regimen and a variety of choices regarding the active ingredients and the form of ap plication (such as oral form, intrauterine systems and patches). In gynecological therapy (hormone therapy), we are developing new treatment options for endometriosis and uterine fibroids. We are also pursuing an andrological research program to identify approaches for male fertility control and to address age-related hormonal imbalances and corresponding disease processes in males.
The following table lists the principal products from the Gynecology&Andrology business area currently under development by the Group, their composition and current development status:
Product/project | Composition | Status |
---|
Oral contraceptives | | |
E2/DNG pill | Estradiolvalerate/dienogest | Phase III |
Lower dose version of Yasmin® | Ethinylestradiol/drospirenone | U.S.: submitted |
Non-oral contraceptives | | |
FC patch | Gestodene/ethinylestradiol | Phase III |
Hormone therapy in menopausal women | | |
Climodien® 1/2 | Estradiolvalerate/dienogest | EU: submitted |
Menostar® | Estradiol transdermal delivery system (patch) | U.S. and EU: submitted |
Menopausal levonorgestrel intrauterine system | Levonorgestrel intrauterine system (IUS) | Phase III |
Gynecological therapy | | |
Endometrion® | Therapy of endometriosis Dienogest (oral) | Phase III |
Oxybutynin releasing vaginal ring | Urge incontinence | Phase II |
Asoprisnil | Treatment of fibroids | Phase III |
Male healthcare | | |
Male fertility control | Gestagen/androgen | Phase II |
The following description provides further information regarding each of the pharmaceutical product development candidates listed in the preceding table:
Oral contraceptives
E2/DNG Pill. The E2/DNG pill will be the first oral contraceptive specifically designed for contraception in the late reproductive years and to introduce natural estrogen (estradiol) in oral contraception. Application of the physiological estradiol (E2) instead of ethinylestradiol (EE) is an innovative approach. E2 will be combined with dienogest (DNG) in a patent protected regimen. Good cycle control is expected, which is a novelty in an oral contraceptive containing estradiol and attributed to the endometrial effect of DNG. Use of this product in the later reproductive age is expected to have benefits beyond contraceptive protection. A potential additional benefit is the effect on Dysfunctional Uterine Bleeding (DUB). DUB is defined as excessive, frequent and irregular menstruation. It is a bleeding due to hormonal disturbances and highly freque nt in the age group 35 – 50 years. Based on the etiology of this condition and the pharmacological profile of the EV/DNG tablet, it is expected that this preparation might be a suitable treatment option. This product is currently undergoing phase III studies.
Lower dose version of Yasmin®. The lower dose version of Yasmin®, containing the same dose of drospirenone but only 0.02 mg of ethinylestradiol, was submitted for registration in the U.S. in 2003 and will be submitted in 2004 in Europe. Further studies are ongoing in order to prove additional benefits of the lower dose version of Yasmin® such as a positive effect on acne and premenstrual dysphoric disorder (PMDD).
Non-oral contraceptives
Patch for Fertility Control (FC Patch). The innovative FC Patch offers Schering AG the essential entrance into the sub-segment of patches within the fertility control market. This monophasic combined transdermal patch has a daily release rate of 17 µg ethinyl-estradiol and 50 µg gestoden. It will be renewed once a week, i. e. three patches (for 21 days) and one week off. The transdermal route of hormone administration will result in improved tolerability. Due to the excellent cosmetic appearance (small transparent matrix patch) and the convenience and user-friendliness ("no missed pills", once-a-week application), high compliance is anticipated. The product is in clinical study phase III.
Hormone therapy in menopausal women
Climodien® 1/2. Climodien® 1/2 is the low dose variation of Climodien®, which is already on the market. It contains 1 mg estradiol valerate combined with 2 mg dienogest in a continuous combined regimen for the treatment of climacteric symptoms in the postmenopause. This lower dose preparation provides the prescribers with the option to titrate estrogen doses according to the women's individual needs without changing the gestagen component. Similar to Climodien®, Climodien® 1/2 provides excellent relief of menopausal symptoms and induces amenorrhoe reliably.
Menostar®. Menostar® (which was formerly known as Climarelle™) is an ultra-low dose patch with an estradiol delivery rate of 12.5 µg/day. The size of the patch is only 3.25 cm2 and the product has an excellent cosmetic appearance. The patch is indicated for osteoporosis prevention, particularly for women in the late postmenopausal stage of the climacterium. No endometrial stimulation is expected and no gestagens will need to be given. Menostar® was submitted for registration both in the U.S. and Europe in 2003. We plan to develop an oral form of Menostar® as well.
Menopausal levonogestrel intrauterine system. We are developing an intrauterine system (IUS) for women in the climacteric. The technology of the IUS has been used successfully for contraception for some years with the product Mirena® and also to protect the endometrium of women in the perimenopause who are receiving estrogen therapy. Women in the postmenopause no longer require contraception. For these women, a smaller version of the IUS is being developed as the uterus shrinks considerably after menopause. The smaller IUS also releases levonorgestrel. If a woman in the postmenopause is on estrogen therapy, this IUS prevents excessive growth of the uterine lining. The project is currently in clinical phase III.
Gynecological therapy
Endometrion®. Endometrion® is a product specifically targeted for convenient oral treatment of endometriosis. Each tablet contains 2 mg dienogest, a gestagen with no estrogenic activity and a track record of excellent tolerance and acceptability. This new preparation is expected to be as effective as GnRH-agonists but with a lower incidence of gestagen deficiency-related side effects. Endometrion submission was withdrawn by Schering to include new supportive clinical data available for refiling in 2005. Endometrion® is in clinical Phase III.
Asoprisnil. Asoprisnil is a progesterone receptor modulator. This new substance class is in clinical development for the treatment of uterine fibroids, i.e. benign tumors of the uterine muscle. This common disease in women is associated with symptoms that can seriously impair the quality of life. Women can suffer from painful, heavy and prolonged menstrual periods. Fibroids can lead to pressure-related symptoms in the uro-genital tract and are also known to cause pelvic pain that is not related to the menstrual cycle. Asoprisnil is being investigated in the regulation of dysfunctional bleeding associated with fibroids. Preliminary results suggest that asoprisnil could also reduce tumor size. Clinical trials to demonstrate that this therapy can also postpone or even eliminate the need for surgery are ongoing. Asoprisnil has the potential to become the first long-term oral medication for the treatment of fibroids. The project is currently in clinical phase III.
Oxybutynin releasing vaginal ring for the treatment of urinary urge incontinence. Effective local medical treatment of urinary incontinence is a long standing need. The overactive bladder, which can seriously impair quality of life, is typically treated with oral anticholinergic drugs which, however, have undesirable systemic effects, such as dry mouth and constipation. We expect from our flexible vaginal ring – loaded with oxybutynin – a distinctly better efficacy and side-effect profile. The product is expected to be submitted for registration in 2007.
The project to develop a vaccine against cervical cancer was discontinued. The project was caried out in cooperation with the company MediGene. The data obtained from a clinical phase I/II trial demonstrated very good tolerability and indicated efficacy. However, the results did not fulfill the high efficacy criteria (efficacy in 90% of the patients) predefined for the continuation of the project.
Male healthcare
Male fertility control. For years, our research has been looking for approaches to hormonal and non-hormonal contraception for men. The most advanced project is male hormonal fertility control. In November 2002, we signed a co-development agreement with Organon. In 2003, the design of a clinical trial was defined. The trial medication and modes of administration are based on results from earlier studies showing that sperm concentrations can be suppressed to contraceptive levels by the gestagen etonogestrel. In the trial, the gestagen, developed by Organon, is given in implant form. As this hormone inhibits the body’s testosterone production, the test persons are injected with a long-acting testosterone undecanoate developed by Schering, which maintains testosterone levels in the blood within the normal range. The phase II study started in 200 4.
We are currently also pursuing additional non-hormonal possibilities of male fertility control in early basic research.
Specialized Therapeutics
Our current research and development efforts in Specialized Therapeutics are focused on the central nervous system, cardiovascular diseases and oncology.
The following table lists the principal products from the Specialized Therapeutics business area currently under development by the Group, their composition and current development status:
Product/project | Indication/description | Status |
---|
Central nervous system | | |
Mesopram™ | Oral treatment of multiple sclerosis | Phase II |
CCR-1 antagonist | Oral treatment of multiple sclerosis | Phase II |
Spheramine | Advanced stages of Parkinson’s disease | Phase II |
Cardiovascular system | | |
AGT-MI | Stable angina pectoris | Phase II/III (enrollment stopped) |
Fasudil oral | Chronic stable angina pectoris | Phase II |
Betaferon® | Viral cardiomyopathy | Phase II |
Oncology | | |
MS-209 | Breast and lung cancer | Phase III |
PTK/ZK | Colon cancer and various solid tumors | Phase III |
Leukine® | Crohn’s disease | Phase III |
The following description provides further information regarding each of the pharmaceutical product development candidates listed in the preceding table:
Central nervous system
Mesopram™. In order to offer a more convenient mode of administration, we are performing a phase II study to investigate whether the oral administration of the PDE IV inhibitor Mesopram™ could be an effective and safe method of administration in patients with multiple sclerosis.
CCR-1 antagonist. The CCR-1 antagonist is investigated as an oral therapy in phase II for the treatment of multiple sclerosis. It may suppress the formation of inflammatory lesions by stopping the recruitment of pro-inflammatory cells into the CNS tissue.
Spheramine. In cooperation with Titan Pharmaceuticals, we are developing Spheramine in phase II for the treatment of patients with advanced Parkinson’s disease. Spheramine represents an innovative cell therapy consisting of retinal pigment epithelial cells that are administered via surgical injection into the brain. It is designed to deliver dopamine to the regions of the brain affected by Parkinson’s disease.
The development of NS-7 (Na/Ca channel blocker) has been discontinued because other priorities required a shift in resources.
Cardiovascular system
AGT-MI. AGT-MI is an angiogenic gene therapy. AGT-MI relieves the symptoms of myocardial ischema in patients who are not good candidates for percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). It promotes the heart’s natural ability to grow collateral vessels, thereby increasing exercise capacity and reducing pain. In January of 2004, we stopped enrollment in phase IIb/III clinical studies. The analysis of interim data on one of the studies led to the conclusion that the studies, as currently designed, would not provide sufficient evidence of efficacy to warrant continued enrollment. No evidence of safety concerns were found. We will continue to examine the potential of this technology.
Betaferon® in viral cardiomyopathy. Acute viral infection of the myocardium may turn into chronic viral infection, leading to progressive myocardial damage and is considered to be an essential cause for the development of cardiomyopathy. Betaferon® is investigated in a phase II study in patients with chronic viral cardiomyopathy with the aim to show improvement of the patients' clinical condition and to achieve a significant or complete reduction of virus load from the myocardium.
Fasudil. We have in-licensed the innovative cardiovascular active substance fasudil from the Japanese pharmaceutical company Asahi Kasei Corporation. An oral formulation of fasudil is in Phase IIa clinical development for the treatment of angina pectoris. Our licensing rights include rights for marketing and sales of the intravenous and oral formulation of fasudil in the United States and Europe.
Oncology
MS-209. Our multidrug resistant modulator is currently in phase III clinical trials in Japan and in phase II clinical trials in the United States and Europe. It is under development for patients with breast and non-small cell lung cancer.
PTK/ZK. PTK/ZK is a novel oral angiogenesis inhibitor that potently inhibits vascular endothelial growth factor (VEGF) receptor tyrosine kinases, important enzymes in the formation of new blood vessels that contribute to tumor growth and metastasis. It has the potential to be the first orally active angiogenesis inhibitor to be used long-term in combination with standard chemotherapy for the treatment of patients with metastatic colorectal cancer. This product is in phase III of clinical development for the treatment of solid tumors, e.g. colon cancer. We are developing this product in collaboration with Novartis AG and have exclusive distribution and marketing rights in Europe.
Leukine® (sargramostim). Leukine® is an infection-fighting, white-blood cell stimulant based on a granulocyte-macrophage colony-stimulating factor (GM-CSF), which is used in hematological oncology. Leukine® is currently being studied for use in treating Crohn’s disease. Crohn’s disease is a chronic and serious inflammatory disease of the gastrointestinal tract. It can affect any part of the digestive tract from the mouth to the anus. The inflammation extends deep into the lining of the affected organ, which can cause pain and frequent bowel movements. Leukine® is believed to stimulate specific immune system cells in the gastrointestinal tract that might be impaired in patients with Crohn’s disease.
Diagnostics&Radiopharmaceuticals
We believe that we are a world leader in the field of in-vivo diagnostic imaging, providing innovative X-ray and magnetic resonance imaging products. Our current research and development projects are directed towards disease specific and functional imaging products that provide an even more accurate and earlier detection of tumors and central nervous system and cardiovascular diseases (sensitive perfusion imaging) as well as molecular imaging of inflammatory and proliferative processes.
The following table lists the principal diagnostic and radiopharmaceutical products currently under development, their indications or area of use and current status:
Product | Indication/description | Status |
---|
Primovist™ | MRI contrast agent/liver imaging | EU: submitted |
SHU 555 C | MRI contrast agent/cardiovascular | Phase III |
MS-325 | MRI contrast agent/cardiovascular | U.S.: submitted |
b-CIT (Dopascan™) | Radiopharmaceutical/Parkinson’s disease | EU: submitted |
Scintimun® Granulocyte | Radiopharmaceutical/infection imaging | EU: submitted |
The following description provides further information regarding each of the pharmaceutical product development candidates listed in the preceding table:
Primovist™ (gadoxetic acid). Primovist™ (formerly known as Eovist®) is an MRI contrast agent for liver-specific imaging being developed for the detection and characterization of hepatic tumors in T1-weighted images.
SHU 555 C (ferucarbotran). SHU 555 C (formerly known as Supravist®) is an MRI contrast agent which is being developed for diagnosing diseases of the vasculature.
MS-325. MS-325 is a gadolinium-based magnetic resonance imaging (MRI) blood pool contrast agent optimized for prolonged vascular enhancement. After intravenous injection, MS-325 binds reversibly to human serum albumin in plasma thus providing an extended imaging time window in addition to a higher relaxivity (efficacy) over currently available contrast agents. MS-325 is designed to provide more flexibility and versatility including high resolution scans in the clinical practice of MRA. The product is being developed in cooperation with EPIX Medical Inc. We own the exclusive sales and marketing rights for MS-325 worldwide. In December 2003, the product was submitted for approval in the U.S.
b-CIT (Dopascan™). b-CIT (Dopascan™) is a radiopharmaceutical, which enables an early and reliable differential diagnosis of Parkinson’s disease versus other diseases with Parkinson-like clinical symptoms. It also supports the right patient management and the assessment of the severity of the disease which will be important for therapy guidance.
Scintimun® Granulocyte. Scintimun Granulocyte is a radio-labeled antibody for the detection of infections and inflammatory lesions in the body including bone marrow imaging. It supports therapy management decisions e.g. in patients with bone inflammations and fever of unknown origin.
Dermatology
Our current research and development efforts in the Dermatology business area are focused on eczema, psoriasis, acne and mycosis.
Our principal product under development in the Dermatology business area is Tisocalcitate (calcitriol analogue). Tisocalcitate is a proprietary compound which is being developed as an ointment formulation for the treatment of plaque type psoriasis. The product is intended to become our first dermatology product to be marketed worldwide. Phase I studies were successfully completed in 2002. Phase II clinical studies were initiated in early 2003.
In August 2003, we terminated the development of Ascrolimus in order to focus our resources on other dermatology product candidates.
Our research and development projects may not survive the development process and may not obtain required regulatory approvals. Even if a development project is approved, it may not be profitable. See "Regulation".
Research and development centers
The Group operates nine research and development centers in Europe, the United States and Japan which employ over 4,000 persons. The following table sets forth the location and principal areas of research for the Group's research and development centers:
Location | Research and development areas |
---|
Berlin, Germany | Diagnostics&Radiopharmaceuticals |
| Gynecology&Andrology |
| Specialized Therapeutics (oncology and neuro-degenerative diseases) |
| Dermatology (inflammatory skin disorders, including eczema and psoriasis) |
Jena, Germany | Gynecology&Andrology |
Turku, Finland | Gynecology&Andrology (new modes of application) |
Saclay, France | Radiopharmaceuticals |
Richmond, California | Oncology, Neurology/Immunology (including MS), selected Cardiovascular diseases and Dermatology |
Seattle, Washington | Oncology, Crohn’s disease |
Indianola, Pennsylvania | Medical devices for diagnostic applications (including vascular injection systems) |
Osaka, Japan | Diagnostics (MRI) |
Mobara, Japan | Specialized Therapeutics (oncology, cardiovascular and central nervous system diseases) |
GROUP ORGANIZATION
Business Areas
Our business areas for Gynecology&Andrology, Specialized Therapeutics, Diagnostics&Radiopharmaceuticals and Dermatology coordinate the development of our product portfolio. The business areas generally have the following objectives:
establish overall portfolio strategy.
establish targets and direction of in-house research.
sponsor and guide pre-clinical drug development activities.
actively develop products through clinical phases I, II and III.
monitor the product approval process in Europe, the United States and Japan.
outline the strategy for the introduction of the product in the market.
stay abreast of new trends in medical research, molecular biology and biopharmacy in order to identify potential new areas for development or potential products for acquisition.
develop an international network of opinion leaders in the medical field to assist in the development of new products.
Group segments
The Group's businesses are comprised of five geographic segments and an Other Activities (primarily pharmaceutical chemicals) segment, as set forth in the following chart:
Schering AG Group |
Europe Region | | United States Region | | Japan Region | | Latin America/ Canada Region | | Asia/ Middle East Region | | Other Activities |
See Note 33 to our Consolidated Financial Statements included elsewhere in this annual report setting forth the net sales, segment performance and segment results, assets and other information for the Group's segments for 2003, 2002 and 2001. See "Item 5-Operating and Financial Review and Prospects" for a discussion of the net sales, segment performance and segment results for the Group's segments for 2003, 2002 and 2001.
The following table sets forth the net sales for each of the Group's five geographic segments and the Other Activities segment for the three years ended December 31, 2003, 2002 and 2001:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales by segment: | | | |
Europe Region | 2,387 | 2,357 | 2,183 |
United States Region | 1,203 | 1,282 | 1,113 |
Japan Region | 517 | 579 | 663 |
Latin America/Canada Region | 383 | 430 | 511 |
Asia/Middle East Region | 199 | 224 | 213 |
Other Activities | 139 | 151 | 159 |
Total | 4,828 | 5,023 | 4,842 |
Europe Region
Overview
The geographic segment referred to in this annual report as the Europe Region comprises the member states of the European Union, all other countries in continental Europe, Turkey, the countries making up the Commonwealth of Independent States, South Africa, Australia, New Zealand and our African export markets (excluding Egypt and Libya). The headquarters of the Europe Region are located in Berlin, Germany. The Group's operations in Europe have been enhanced by a number of key acquisitions in recent years, including Schering Oy (1996), Jenapharm (1996/2001), CIS bio international (2000/2001) and MAP Medical Technologies Oy, which we acquired in July 2002. CIS specializes in the development, production and distribution of radiopharmaceuticals with MAP complementing those activities in the Nordic coun tries.
The Europe Region accounted for approximately 49% of the Group's net sales in 2003. As of December 31, 2003, the Europe Region employed 8,196 persons. The decrease in personnel compared to 2002 was mainly due to the divestment of Oy Leiras Finland AB, Finland.
The following table sets forth net sales by business area of the Europe Region for the years ended December 31, 2003, 2002 and 2001:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales Europe Region by business area: | | | |
Gynecology&Andrology | 971 | 921 | 845 |
Specialized Therapeutics | 835 | 843 | 749 |
Diagnostics&Radiopharmaceuticals | 449 | 450 | 442 |
Dermatology | 125 | 132 | 135 |
Other sources | 7 | 11 | 12 |
Total | 2,387 | 2,357 | 2,183 |
Among the factors that have affected, or may affect, the business of the Europe Region are:
Healthcare cost containment measures effected by governments, institutions and managed care organizations.
Intense price competition for diagnostic products.
Market entry of generic products, particularly in diagnostics and the fertility control and hormone therapy products.
Exchange rate effects in countries outside the euro territory.
We believe that the key competitive strengths of the European business are our subsidiaries and their sales forces, strong presence and market leadership in strategic product fields, the excellent reputation of the Schering AG brand, and good synergies among the countries in the Europe Region through regional business processes and the exchange of country-specific know-how.
Products
The following table sets forth our top-selling products in 2003 and in 2002 in the Europe Region. These products represented 55% of the total net sales for the Europe Region in 2003 (51% in 2002).
| Net sales 2003 (€million) | Percentage change from 2002 | Net sales 2002 (€million) | Percentage change from 2001 |
---|
1. Betaferon® | 402 | 8 | 372 | 14 |
2. Ultravist® | 147 | (1) | 148 | 2 |
3. Diane® | 143 | (10) | 158 | 6 |
4. Yasmin® | 115 | 113 | 54 | 96 |
5. Mirena® | 108 | 18 | 92 | 14 |
6. Magnevist® | 95 | 3 | 92 | 9 |
7. Meliane® | 91 | 1 | 90 | 15 |
8. Androcur® | 80 | 2 | 79 | 1 |
9. Microgynon® | 64 | 6 | 60 | 4 |
10. Fludara® | 59 | 16 | 51 | 12 |
Total | 1,304 | | 1,196 | |
Marketing and distribution
Marketing functions for the Europe Region are centralized at regional headquarters in Berlin, Germany.
The following table sets forth the main target groups for the marketing of our products in the Europe Region:
Gynecology&Andrology | gynecologists, general practitioners |
Specialized Therapeutics | neurologists, oncologists, hematologists, hospitals, urologists |
Diagnostics&Radiopharmaceuticals | radiologists, nuclear physicians, urologists, cardiologists, hospitals |
Dermatology | dermatologists, general practitioners |
Our products are marketed by 2,297 sales representatives located in each of the countries in the Europe Region. Each country has its own sales force and marketing organization. Promotion of our products is supplemented by scientific seminars, advertising in medical and other journals and innovative marketing tools such as the Internet.
We generally distribute our products through wholesalers, pharmacies or directly to the target groups.
We actively seek, where appropriate, to supplement the efforts of our sales force through copromotion arrangements and co-marketing arrangements. We have a co-marketing agreement with the Wyeth, Inc. for the oral contraceptive substance gestodene for the Europe Region (other than South Africa, Australia and New Zealand). We also have several co-promotion agreements for specific countries, including iloprost in Italy and contrast media products in Spain.
Production
In Europe, we produce active pharmaceutical ingredients and intermediate products at our primary facility in Bergkamen, Germany and three smaller facilities in Germany, Finland and Spain. The Bergkamen facility is presently operating at high capacity. These European production facilities produce much of the requirements for all of the Group's regions.
In addition to our active pharmaceutical ingredient production operations, we operate production facilities for the formulation and packaging of pharmaceutical products. The following table sets forth, as of December 31, 2003, the location of, and dosage form produced at, our production facilities in the Europe Region.
Dosage Form | Location |
---|
Solids | Weimar, Berlin, Hamburg, Germany; Lys-Lez-Lannoy, France; Turku, Finland |
Semisolids | Milan, Italy |
Liquids/parenterals | Berlin, Germany; Alcalá de Henares, Spain; Milan, Italy |
Radiopharmaceuticals | Saclay and Marcoule, France |
Others(1) | Turku, Finland |
(1) Implants, intrauterine systems |
For a discussion of certain rationalization measures involving our European production and packaging facilities, see "Item 5-Operating and Financial Review and Prospects-Liquidity and Capital Resources-Restructuring Program".
Capital expenditures
Capital expenditures for the Europe Region were €167m in 2001, €202m in 2002 and €172m in 2003. We spent these expenditures mainly in the areas of production facilities (including the European Production Initiative) and distribution facilities and to modernize information technology. Capital expenditures are expected to total €200m in 2004 and are being used to upgrade and modernize manufacturing facilities as well as research and development and administrative functions in order to meet regulatory, health, safety and environmental requirements and to improve processes.
United States Region
Overview
The geographic segment referred to in this annual report as the United States Region comprises the United States of America and Puerto Rico. We market pharmaceutical products in the United States under the trade name Berlex Inc. (in 2003, Berlex Laboratories, Inc., changed its name to Berlex Inc.) as well as injection systems and disposable products through our subsidiary Medrad, Inc. As discussed under "Patents and Other Intellectual Property", we generally are not permitted to market healthcare products in the United States Region under the Schering name.
Schering Berlin Inc. is the management holding company for the United States interests of Schering AG. Through its operating subsidiaries, Schering Berlin supports Schering AG's strategic global interests in pharmaceuticals and medical devices. Located in Montville, New Jersey, Schering Berlin provides specialized management expertise and develops long range plans for its United States subsidiaries. Schering Berlin has four principal subsidiaries:
Berlex Inc. is located in Wayne and Montville, New Jersey, Richmond, California, Londonderry, New Hampshire as well as Seattle and Bothell, Washington. Berlex is committed to marketing products from the business areas of Diagnostics&Radiopharmaceuticals, Gynecology&Andrology and Specialized Therapeutics to the United States, and has recently established the business area Dermatology.
Medrad, Inc. Medrad focuses on innovative products for diagnostic imaging and specializes in vascular injection systems for contrast media. Medrad is a market leader in the development, manufacturing and sale of injectors, syringes and disposable products in this area. Medrad, with headquarters in Indianola, Pennsylvania, has developed an international market presence. We acquired Medrad in 1995.
Berlipharm, Inc. Berlipharm, Inc. centralizes various U.S. operations which provide services to Schering AG with respect to aspects of Schering AG’s global business. In particular, Berlipharm currently provides services to Schering AG in the following areas: Specialized Therapeutics, Global Patents and Corporate Business Development. We will merge Berlipharm into Berlex Inc. in 2004.
The United States Region accounted for approximately 25% of the Group's net sales in 2003. As of December 31, 2003, the United States Region has 3,711 employees (including 1,012 sales representatives).
The following table sets forth net sales by business area of the United States Region for the years ended December 31, 2003, 2002 and 2001:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales United States Region by business area: | | | |
Gynecology&Andrology | 271 | 252 | 187 |
Specialized Therapeutics | 500 | 561 | 485 |
Diagnostics&Radiopharmaceuticals | 423 | 460 | 437 |
Dermatology | 9 | 9 | 4 |
Total | 1,203 | 1,282 | 1,113 |
Among the factors that have affected, or may affect, the business of the United States Region are:
Competition from large pharmaceutical companies in the United States market with substantial resources for research, product development and promotion.
Increasingly competitive price pressures as managed care groups, institutions, government agencies and other purchaser groups seek price discounts and rebates for pharmaceutical products.
Intense price competition for diagnostic products.
Impact of market entry of competing generic products, particularly in the Gynecology&Andrology business area (including oral contraceptives and Climara®) and in the Specialized Therapeutics business area (including Betapace® and Fludara® ).
Adverse currency effects.
We believe that the key competitive strengths of the United States business are our know-how in building new markets and high-quality customer service.
Products
During 2003, approximately 77% of our net sales in the United States Region were generated from sales of products from the Specialized Therapeutics and Diagnostics&Radiopharmaceuticals business areas. One of the Group's key strategic objectives is to broaden the product lines in the United States in the areas of fertility control, hormone therapy, contrast media, specialized therapeutics and dermatology.
The following table sets forth our top-selling pharmaceutical products in 2003 and in 2002 in the United States Region. These products represented 58% of the total net sales for this segment in 2003 (54% in 2002).
| Net sales 2003 (€million) | Percentage change from 2002 | Net sales 2002 (€million) | Percentage change from 2001 |
---|
1. Betaseron® | 286 | (15) | 336 | 18 |
2. Yasmin® | 152 | 60 | 95 | 454 |
3. Magnevist® | 131 | (9) | 145 | 2 |
4. Leukine® | 64 | 93 | 33 | * |
5. Fludara® | 61 | (25) | 82 | 17 |
Total | 694 | | 691 | |
* Leukine® was acquired in 2002. |
Medrad's principal product line is vascular injection systems (equipment, related disposables, and equipment service) for angiography, computed axial tomography (CT), magnetic resonance imaging and ultrasound. Medrad had net sales of €252m in 2003.
Marketing and distribution
The following table sets forth the main target groups for the marketing of our products in the United States Region:
Specialized Therapeutics | neurologists, oncologists, cardiologists, hematologists, hospitals |
Diagnostics&Radiopharmaceuticals | radiologists, hospitals, free standing imaging centers |
Gynecology&Andrology | gynecologists, selected primary care physicians |
Dermatology | dermatologists |
Medrad | radiologists, hospitals |
Our pharmaceutical products are marketed by our 1,012 sales representatives as well as additional contract sales representatives. Promotion of our products is supplemented by physician training, scientific seminars, advertising in medical and other journals, samples and direct-to-consumer campaigns to increase awareness in the market.
We generally distribute pharmaceutical products through wholesalers and pharmacies or directly to end-consumer groups. We have contract arrangements with hospital groups and managed care groups that in turn receive our products at contract prices through wholesalers.
Medrad markets its products to target groups through its own sales force located in its major markets. Products are also marketed to end-customer groups indirectly through original equipment manufacturers (OEMs), group purchasing organizations (GPOs) and managed care groups. Third-party distributors serve Medrad's smaller markets.
Production
The pharmaceutical products we market in the United States Region are generally manufactured by the Group's European facilities or under various manufacturing agreements with third parties. We operate two pharmaceutical production plants in the United States Region. One plant, located in Wayne, New Jersey, packages solid and special dosage forms. A second plant located in Seattle, Washington, produces Leukine®.
Medrad develops and manufactures its products at its facilities in Indianola and Pittsburgh, Pennsylvania.
Capital expenditures
Capital expenditures for the United States Region were €28m in 2001, €44m in 2002 and €36m in 2003. Capital expenditures are expected to total €60m in 2004.
In addition to information technology and research equipment purchases, capital projects currently in progress include the expansion of the clinical production area in Richmond, California, to support upcoming clinical trials. Expenditures for Medrad include an expansion of its manufacturing facilities in Indianola and Pittsburgh, Pennsylvania.
Japan Region
Overview
The geographic segment referred to in this annual report as the Japan Region comprises the geographical territory of Japan and comprises the business of Nihon Schering K.K. in Japan and direct sales by Schering AG to Tanabe Seiyaku Co., Ltd. of an X-ray contrast medium as well as to Yamanouchi Pharmaceutical Co., Ltd. of an oral contraceptive. The Japan Region accounted for approximately 11% of the Group's net sales in 2003. As of December 31, 2003, the Japan Region has 1,560 employees (including 664 field staff).
The following table sets forth the net sales by business area of the Japan Region for the years ended December 31, 2003, 2002 and 2001:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales Japan Region by business area: | | | |
Gynecology&Andrology | 28 | 30 | 29 |
Specialized Therapeutics | 117 | 129 | 145 |
Diagnostics&Radiopharmaceuticals | 342 | 386 | 451 |
Dermatology | 30 | 34 | 38 |
Total | 517 | 579 | 663 |
Among the factors that have affected, or may affect, the business of the Japan Region are:
Adverse exchange-rate effects.
The regulation of pharmaceutical prices and mandatory price reductions by the Japanese Ministry of Health, Labour and Welfare.
Extensive periods of time historically required for the development and the approval of new drug applications by the Japanese Ministry of Health, Labour and Welfare.
Increasing competition from generics.
We believe that the key competitive strengths of the Japan Region's business are the flexibility of our sales force to market products from any of our four business areas, our strong market presence and reputation in diagnostics, and our proven ability to develop our pipeline of diagnostics and radiopharmaceuticals, specialized therapeutics and fertility control and hormone therapy products.
Products
The following table sets forth our top-selling products in 2003 and in 2002 in the Japan Region. These products represented 67% of the total net sales for this segment in 2003 (67% in 2002).
| Net sales 2003 (€million) | Percentage change from 2002 | Net sales 2002 (€million) | Percentage change from 2001 |
---|
1. Iopamiron® | 227 | (13) | 261 | (16) |
2. Magnevist® | 55 | (13) | 63 | (12) |
3. Betaferon® | 25 | 10 | 23 | 53 |
4. Aspenon® | 21 | (12) | 24 | (17) |
5. Ultravist® (Proscope®) | 19 | (2) | 19 | (3) |
Total | 347 | | 390 | |
Marketing and distribution
The following table sets forth the main target groups for the marketing of our products in the Japan Region:
Diagnostics&Radiopharmaceuticals | hospital and general practitioner radiologists, urologists, neurosurgeons, cardiologists; clinical laboratories |
Specialized Therapeutics | hospital internists, surgeons, neurosurgeons, neurologists, cardiologists, urologists, gynecologists; oncologists, hematologists, general practitioner internists and surgeons |
Dermatology | hospital and general practitioner dermatologists, surgeons |
Gynecology&Andrology | hospital gynecologists; general practitioner gynecologists and internists |
Our products are marketed to their customers by our 664 field staff. Our sales and marketing efforts in the Japan Region are directed by our head office in Osaka. Promotion of our products is supplemented by scientific seminars, trade congresses and advertising in medical journals. We distribute our products through wholesalers.
We have marketed with Tanabe Seiyaku Co., Ltd. the ACE-inhibitor Novarok® (cardiovascular) and with Yamanouchi Pharmaceutical Co., Ltd. the low-dose oral contraceptive Libian® (the trademark under which Triquilar® is marketed). Additionally, we have a co-promotion agreement with Tanabe for our ultrasound contrast agent Levovist®. We also distribute Proscope®, the Japanese brand name for the X-ray contrast medium Ultravist®, to Tanabe.
Production
We mostly distribute products in Japan that are manufactured by the Group's European facilities. The packaging of these products takes place at our site in Osaka. Furthermore, we operate a production plant in Mobara, which is engaged in manufacturing and packaging of certain therapeutic products. The packaging and distribution of in-vitro diagnostics is carried out at a smaller site in Sakura.
We produce and distribute Iopamiron®, our top selling product in the Japan Region, under a license from Bracco S.p.A. Changes in the contractually-determined price of iopamidol, the active ingredient of Iopamiron®, have significantly affected the results of operations of the Japan Region in prior periods. See "Item 5-Operating and Financial Review and Prospects-Results of Operations-2003 Compared to 2002-Results of Operations by Segment-Japan Region" and "-2002 Compared to 2001-Results of Operations by Segment-Japan Region".
Capital expenditures
Capital expenditures for the Japan Region were €8m in 2001, €7m in 2002 and €5m in 2003. Capital expenditures are expected to total €11m in 2004.
Expenditures were spent mainly in the areas of production facilities and the modernization of information technology.
Latin America/Canada Region
Overview
The Group's geographic segment for Latin America and Canada, referred to in this annual report as the Latin America/Canada Region, consists of the countries of Central America, South America, the Caribbean and Canada. Schering AG has had a presence in this region since the 1920s. The headquarters of the Latin America/Canada Region (known as CECLA-Centro Estrategico Canada Latinoamerica) are located in Mexico City, Mexico, and manage the activities of 15 subsidiaries in the major countries of the region. The Latin America/Canada Region accounted for approximately 8% of the Group's net sales in 2003. As of December 31, 2003, the Latin America/ Canada Region has 2,456 employees (including 934 sales representatives).
The following table sets forth the net sales by business area of the Latin America/Canada Region for the years ended December 31, 2003, 2002 and 2001.
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales Latin America/Canada Region by business area: | | | |
Gynecology&Andrology | 254 | 292 | 340 |
Specialized Therapeutics | 73 | 73 | 84 |
Diagnostics&Radiopharmaceuticals | 29 | 33 | 45 |
Dermatology | 22 | 26 | 33 |
Other sources | 5 | 6 | 9 |
Total | 383 | 430 | 511 |
Among the factors that have affected, or may affect, the business of the Latin America/ Canada Region are:
Adverse exchange-rate effects in all major markets in Latin America.
Impact of competing generic products and copies, which is encouraged by the governments of the region.
Direct and indirect price controls imposed by regulatory authorities.
Factors generally associated with operating in developing countries, including the risk of political and economic instability, such as the recent economic crises in Argentina, Mexico, Brazil, Venezuela and Uruguay, our major markets in Latin America.
Fierce competition by local and regional companies concentrating in our specialized market segments.
We believe that the key competitive strengths of our business in the Latin America/Canada Region are:
In the area of fertility control, our specialized sales force, franchise and expertise.
In Latin America, our leadership position in fertility control and diagnostics, and our strong market position in hormone therapy and dermatology as well as our expertise in Specialized Therapeutics.
In Canada, our strong market position in specialized therapeutics, particularly the treatment of multiple sclerosis and oncology, and our recognized strong position in fertility control and hormone therapy.
Products
The following table sets forth our top-selling products in 2003 and in 2002 in the Latin America/Canada Region. These products represented 43% of the total net sales for this segment in 2003 (46% in 2002).
| Net sales 2003 (€million) | Percentage change from 2002 | Net sales 2002 (€million) | Percentage change from 2001 |
---|
1. Diane® | 43 | (15) | 51 | (1) |
2. Microgynon® | 37 | (16) | 44 | (19) |
3. Betaferon® | 45 | 4 | 43 | (7) |
4. Meliane® | 24 | (28) | 34 | (18) |
5. Femovan® | 17 | (32) | 25 | (27) |
Total | 166 | | 197 | |
Marketing and distribution
The following table sets forth the main target groups for the marketing of our products in the Latin America/Canada Region:
Gynecology&Andrology | gynecologists, obstetricians, general practitioners, endocrinologists, hospitals |
Specialized Therapeutics | oncologists, hematologists, urologists, neurologists, hospitals |
Diagnostics&Radiopharmaceuticals | radiologists, cardiologists, selected hospitals |
Dermatology | dermatologists |
Our products are marketed by 934 sales representatives in almost all of the countries of the Latin America/Canada Region. Each of our 15 subsidiaries has its own marketing organization, which is supported by regional headquarters in the areas of strategy development, the coordination of new product introductions as well as in-licensing activities. Promotion of our products is supplemented by scientific seminars, advertising in medical and other journals and innovative marketing tools such as the internet, Customer Relationship Management (CRM) tools such as call centers, service hotlines for our customers and a direct-to-consumer campaign in Canada.
We generally distribute our products through wholesalers, pharmacies, hospitals, clinics and, in some cases, directly to the target groups. We maintain a distribution center in Colon, Panama, to serve as a regional hub for the distribution of products among our companies in Latin America.
Production
Certain of the pharmaceutical products we market in the Latin America/Canada Region are manufactured by the Group's European facilities. At our facility in Orizaba, Veracruz, Mexico, we produce active pharmaceutical ingredients and intermediate products for the requirements of all of the Group's regions.
The following table sets forth, as of December 31, 2003, the location of, and dosage forms produced by, our four production facilities in the Latin America/Canada Region:
Dosage form | Location |
---|
Solids | São Paulo, Brazil Santafé de Bogotá, Colombia Orizaba, Mexico |
Semisolids | Buenos Aires, Argentina Santafé de Bogotá, Colombia Orizaba, Mexico |
Liquids | Buenos Aires, Argentina Orizaba, Mexico |
Capital expenditures
Capital expenditures for the Latin America/Canada Region were €21m in 2001, €23m in 2002 and €14m in 2003. Capital expenditures are expected to total €11m in 2004.
Expenditures were spent mainly in the areas of production facilities and distribution facilities and modernization of information technology. We are currently building a new office in Mexico City as well as a new office building in Santo Domingo, Dominican Republic. The estimated cost of these projects, which are expected to be completed in 2004, is €5m.
Asia/Middle East Region
Overview
The geographic segment referred to in this annual report as the Asia/Middle East Region comprises the countries of Asia (with exception of Japan), and of the Near and Middle East, Egypt, and Libya. Turkey and the countries of Central Asia (including the Commonwealth of Independent States members) are not included in the Asia/Middle East Region. The headquarters of the Asia/Middle East Region are located in Berlin, Germany, and manage the operations of our subsidiaries in South Korea, China, Taiwan, Thailand, Indonesia and the Philippines and our branch offices and distributors in all the other major countries of the region. The Asia/Middle East Region also operates production facilities in South Korea, China and Indonesia. The Asia/Middle East Region accounted for approximately 4% of the Group's net sales in 2003. As of Decembe r 31, 2003, the Asia/Middle East Region has 1,358 employees (including 581 sales representatives).
The following table sets forth the net sales by business area of the Asia/Middle East Region for the years ended December 31, 2003, 2002 and 2001:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales Asia/Middle East Region by business area: | | | |
Gynecology&Andrology | 85 | 93 | 81 |
Specialized Therapeutics | 32 | 30 | 27 |
Diagnostics&Radiopharmaceuticals | 69 | 77 | 77 |
Dermatology | 13 | 14 | 15 |
Other sources | 0 | 10 | 13 |
Total | 199 | 224 | 213 |
Among the factors that have affected, or may affect, the business of the Asia/Middle East Region are:
Exchange-rate effects.
Factors generally associated with operating in developing countries, including the risk of political and economic instability.
Certain of our fertility control products are purchased by institutional clients (including governments and non-government organizations) with unpredictable purchasing patterns, which can result in fluctuations in net sales and profitability from period to period.
We believe that the key competitive strengths of our business in the Asia/Middle East Region are:
Our specialized product portfolio, particularly in diagnostics as well as fertility control and hormone therapy.
Our strong market presence and high market share in diagnostics and radiopharmaceuticals as well as fertility control and hormone therapy.
Products
The following table sets forth our top selling products in 2003 and in 2002 in the Asia/Middle East Region. These products represented 52% of the total net sales for this segment in 2003 (47% in 2002).
| Net sales 2003 (€million) | Percentage change from 2002 | Net sales 2002 (€million) | Percentage change from 2001 |
---|
1. Ultravist® | 50 | (9) | 55 | 5 |
2. Diane® | 16 | (5) | 17 | 23 |
3. Magnevist® | 13 | (10) | 14 | 3 |
4. Microgynon® | 13 | 12 | 11 | 4 |
5. Betaferon® | 12 | 29 | 9 | 23 |
Total | 104 | | 106 | |
Marketing and distribution
The following table sets forth the main target groups for the marketing of our products in the Asia/Middle East Region:
Gynecology&Andrology | gynecologists, general practitioners, hospitals |
Diagnostics&Radiopharmaceuticals | radiologists, cardiologists, hospitals |
Specialized Therapeutics | general practitioners, oncologists, hematologists, hospitals |
Our products are marketed by 581 sales representatives located in all of the major markets of the Asia/Middle East Region. Our local sales and marketing organizations receive support from our Asia/Middle East Region headquarters in Berlin. Promotion of our products is supplemented by scientific seminars, workshops and advertising in medical journals.
In Taiwan, Thailand, Indonesia, the Philippines, Hong Kong, Malaysia and Singapore, we distribute our products through an exclusive distributor. In South Korea and China, we generally distribute our products through various wholesalers and pharmacies and, in some cases, directly to hospitals. In the Middle Eastern countries, we are for the most part represented by agents that import and distribute our products through their organizations.
Production
Certain of the pharmaceutical products we market in the Asia/Middle East Region are manufactured by the Group's European facilities.
The following table sets forth, as of December 31, 2003, the location of, and dosage forms produced by our four production facilities in the Asia/Middle East Region:
Dosage form | Location |
---|
Solids | Jakarta, Indonesia Nanjing, China |
Semi-solids | Ansung, South Korea |
Liquids | Guangzhou, China Ansung, South Korea |
Others(1) | Guangzhou, China |
(1) Intrauterine systems |
We also license the production of certain of our products in Pakistan and India for sale in the local markets.
Capital expenditures
Capital expenditures for the Asia/Middle East Region were €5m in 2001, €4m in 2002 and €4m in 2003. Capital expenditures are expected to total €3m in 2004.
Expenditures were mainly spent for upgrading of production facilities and the modernization of information technology.
Other Activities
The Other Activities segment is comprised of activities that are not of sufficient significance to require independent segment reporting. The Other Activities segment primarily consists of Pharmaceutical chemicals. The Other Activities segment accounted for approximately 3% of the Group's net sales in 2003.
The following table sets forth the net sales by business of the Other Activities segment for the years ended December 31, 2003, 2002 and 2001:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (€million) |
---|
Net sales by sub-segment: | | | |
Pharmaceutical chemicals | 118 | 121 | 118 |
Other | 21 | 30 | 41 |
Total | 139 | 151 | 159 |
Pharmaceutical chemicals is a small sales- and profit-oriented business unit with headquarters in Berlin, Germany. Pharmaceutical chemicals engages in the sale to third parties of intermediates and active pharmaceutical ingredients produced by the Group worldwide, particularly the Group's manufacturing facilities in Bergkamen, Germany, and Orizaba, Mexico. Pharmaceutical chemicals also is active in tailor-made chemistry. The pharmaceutical chemicals marketed include estrogens, gestagens, androgens, corticosteroids, intermediates and tailor- made chemistry compounds. Sales to customers in Europe and the United States accounted for approximately 52% and 43%, respectively, of Pharmaceutical chemicals' net sales during 2003.
COMPETITION
We operate in a competitive global market. We encounter competition in all of our geographical markets from large national and international competitors. Important competitive factors include:
product characteristics and dependability (including safety, efficacy, range of indications, dosage form and convenience).
product price and demonstrated cost-effectiveness.
customer training and support.
sales force size and expertise.
advertising and promotion.
production and manufacturing costs.
research and development of new products and processes.
Gynecology&Andrology
Our principal competitors in the markets for hormonal contraception and menopause management products are Wyeth, Inc., Johnson & Johnson's Ortho division, Novartis International AG, the Organon division of Akzo Nobel nv as well as Barr Laboratories Inc. and Watson Pharmaceuticals Inc.
Our principal competitors in male healthcare are Pfizer Inc., the Organon division of Akzo Nobel nv and The Bristol-Myers Squibb Company.
Specialized Therapeutics
The global markets for our specialized therapeutics products are highly competitive and include large as well as smaller niche competitors. Our major competitors include Biogen Idec Inc., Serono International S.A., Pfizer Inc. and Aventis S.A., Teva Pharmaceutical Industries Limited in the field of multiple sclerosis therapeutics; Wyeth, Inc. and Pfizer Inc. in the area of cardiovascular products; and F. Hoffmann-La Roche Ltd. and its subsidiary Genentech, Inc., Bristol-Myers Squibb Company, AstraZeneca PLC, Amgen, Inc., Novartis AG and Schering-Plough Corporation in oncology.
Diagnostics&Radiopharmaceuticals
Our principal competitors in the X-ray and MRI contrast media field include Amersham plc, Bracco S.p.A., Mallinckrodt Inc., Tyco Healthcare Group LP., and, in Japan, Daiichi Pharmaceutical Co., Ltd. Other significant competitors include Guerbet S.A. in Europe, Latin America and Asia (other than Japan), Altana Pharma AG in Europe and Eisai Co. LtD. and Yamanouchi Pharmaceutical Co., LtD. in Japan. Generic X-ray and MRI contrast agents have not had a significant impact on our contrast media sales. However, we consider generic X-ray and MRI extracellular agents a potential risk to sales and market share in the future.
The radiopharmaceuticals market is dominated by a small number of companies. As we expand our business in this field, our main competitors are expected to include Amersham plc, the Bristol-Myers Squibb Company and Mallinckrodt Inc. in the United States and Europe and Nihon Medi-Physics Co., LtD. and Daiichi Radioisotope Laboratories, LtD. in Japan.
In the market for contrast media application technologies, Medrad's main competitors are the Liebel-Flarsheim unit of Mallinckrodt Inc., particularly in the United States and Europe, and Nemoto Kyorindo Co., Ltd., particularly in Japan.
Dermatology
We primarily compete with marketers of products for the treatment of eczema, acne, psoriasis, mycoses and hemorrhoids. Our principal competitors include Johnson & Johnson, F. Hoffmann-La Roche Ltd., Novartis International AG, Schering-Plough Corporation and Wyeth, Inc. as well as Galderma S.A., Dermik Laboratories Inc., and Pierre Fabre S.A.
PATENTS AND OTHER INTELLECTUAL PROPERTY
We strive to protect our investment in research, development, manufacturing and marketing through the use of patents, trademarks and copyrights.
We believe that our patents are important to our business, but no one patent (or group of related patents) currently is of material importance in relation to our business as a whole. Patent protection for new active ingredients of pharmaceuticals, pharmaceutical formulations and combinations, manufacturing processes, intermediates useful in the manufacture of products and new uses of products is available in our major markets. Patents for individual products extend for varying periods according to the date a patent application is filed or a patent is granted and the legal term of patents in the jurisdiction where the patent is obtained. The actual protection provided by a patent, which can vary significantly from country to country, depends upon:
the type of granted claim.
the scope of coverage of the claim.
the availability of legal remedies in the country for enforcing a patent.
Our policy is to develop patent portfolios for our research and development projects in order to obtain market exclusivity for our products in our major markets. We also attempt to obtain patents on drug targets such as specific DNA sequences encoding for proteins and various uses of such subject matter in drug research.
Although the expiration of a patent for an active ingredient normally results in the loss of market exclusivity, we may continue to derive commercial benefits from:
later-granted patents on processes and intermediates related to the most economical method of manufacture of the active ingredient of such product.
patents relating to the use of such active ingredient.
patents relating to novel compositions and formulations.
in certain markets (including the United States), market exclusivity that may be available under applicable law.
Such commercial benefits strongly depend on the actual scope of protection.
In addition, the effect that the expiration of a patent has on the market position of a product can depend on many other factors, including:
the nature of the market and the position of the product covered by the patent in the market.
the growth of the market.
the complexities and economics of the manufacture of the product covered by the patent.
the requirements of new drug laws and regulations relating to the introduction of generic drugs.
The European Union, the United States, Japan and certain other countries provide for the extension or restoration of patent terms or supplementary protection certificates to compensate for patent term loss due to the regulatory review process and the substantial investment made for product research and development and regulatory approval. Our policy is to obtain these extensions where possible.
In the United States, new chemical entities approved by the FDA receive a period of five years exclusivity from the date of approval of the New Drug Application (NDA), during which time an abbreviated “NDA" or "paper NDA" may not be submitted to the FDA. Similarly, in the case of non-new chemical entities, no abbreviated NDA or paper NDA may become effective before three years from the time of NDA approval if the application included new data of clinical investigations conducted or sponsored by the applicant. In addition, a pediatric exclusivity provision that provides for an additional six months of market exclusivity in the United States for indications of new or currently marketed drugs may be available if certain agreed upon pediatric studies are completed by the applicant.
The Orphan Drug Act in the United States is intended to provide incentives to manufacturers to develop and market drugs for rare diseases or conditions affecting fewer than 200,000 persons in the United States at the time of application for orphan drug designation. The first applicant who has obtained designation of a drug for a particular use as an orphan drug and then obtains approval of a marketing application for such drug for a particular use is entitled to marketing exclusivity for a period of seven years, subject to certain limitations. However, a drug that is considered by the FDA to be different from a particular orphan drug is not barred from sale in the United States during such seven-year exclusive marketing period even if it receives marketing approval for the same product claim.
The European Union also implemented an incentive program for the development of drugs for rare diseases which became effective in January 2000. Under the rules, a drug will be designated as an orphan medicinal product if its sponsor establishes at the time of application that the drug is intended for the diagnosis, prevention or treatment of a life-threatening or chronically debilitating condition affecting not more than five in 10,000 persons in the European Community, or that without incentives, it is unlikely that the marketing of the drug would generate sufficient return to generate the necessary investment. The sponsor must also establish that there is no existing satisfactory method for the diagnosis, prevention or treatment of the condition in the European Community. A sponsor who receives designation of a drug as an orp han drug is generally entitled to marketing exclusivity for a period of ten years (which period may be reduced to six years if the criteria for orphan drug status are no longer met). A marketing authorization may be granted for the same therapeutic indication to a similar drug within the exclusivity period if the holder of the authorization for the original orphan drug is unable to supply sufficient quantities of the drug or if an applicant can establish that its drug is safer, more effective or otherwise clinically superior to the original orphan drug.
Certain of our key products are no longer protected by patents (or other regulatory exclusivity measures) in our major markets, or protection for these products will expire in the near future. Many of our fertility control products have no patent protection remaining.
The following table sets forth the patent expiration dates of certain of our top selling products in certain of our major markets:
| Expiration date |
---|
Product | Germany | France | Italy | Great Britain | United States | Japan |
---|
Betaferon® (Betaseron®) | | | | | | |
Product | 2008* | 2008* | 2008* | 2008* | 2007* | 2003**** |
Leukine® | | | | | | |
Product | 2006 | 2006 | 2006 | 2006 | 2012 | 2006 |
Magnevist® | | | | | | |
Product | — | 2005* | 2007# | — | 2011 | — |
Formulation | 2007 | 2007 | 2007 | 2007 | 2009 | 2007 |
Method of use | — | — | — | — | 2013 | — |
Ultravist® | | | | | | |
Product | — | 2005* | 2009# | — | 2005* | 2005* |
Femovan® | | | | | | |
Product | — | — | 2005# | — | — | — |
Process | 2006 | 2006 | 2006 | 2006 | 2005*** | 2006 |
Fludara® | | | | | | |
Product | 2018 | 2018 | 2018 | 2018 | 2003 | — |
Process I | 2013 | 2013 | 2013 | 2013 | 2014 | 2013 |
Process II | 2012 | 2012 | 2012 | 2012 | 2015 | 2012 |
Mirena® | | | | | | |
Device | — | — | — | — | 2004 | — |
Device (Inserter) | 2015 | 2015 | 2015 | 2015 | 2015 | — |
Process | 2013 | 2013 | 2013 | 2013 | 2013 | 2013 |
Yasmin® | | | | | | |
Formulation | 2020 | 2020 | 2020 | 2020 | 2020** | 2020** |
Milvane® | | | | | | |
Product | 2004 | 2004 | 2004 | 2004 | — | 2004 |
Process | 2006 | 2006 | 2006 | 2006 | 2005*** | 2006 |
* Patent term extension ** Patent pending *** Product not sold in the United States **** Appeal against rejection of patent term extension pending # Action against administrative recalculation pending |
We monitor the patent applications and related activities of our competitors and other third parties. In cases where we believe that patents granted do not meet the standards of patentability and such patents may potentially have an adverse impact on our current or future business, we oppose the grant of such patents in countries where such opposition is feasible, particularly through oppositions in the European Patent Office, and nullity proceedings in front of various national courts. Similarly, third parties may commence proceedings to oppose or nullify the grant of patents to the Group. These proceedings may result in the revocation of any of our existing or future patents.
We routinely monitor the activities of our competitors and other third parties with respect to their use of intellectual property. In cases where we believe our patents have been infringed, we generally file patent infringement suits with the appropriate courts. We may not be successful in these patent infringement suits. Likewise, we may be exposed to litigation by competitors or other third parties that consider their patents to be infringed by our activities. Patent litigation is often time-consuming and expensive. If we do not prevail in patent litigation, we may have to pay substantial damages or royalties to a competitor or other third party. We may also be enjoined from selling a product in one or more markets or from conducting research and development activities in a specific area. For a discussion of certain patent-re lated litigation in which we are involved, see "Item 8-Financial Information-Legal Proceedings".
Worldwide, all of our major products are sold under trademarks that we consider in the aggregate to be important to the Group. Trademark protection varies widely throughout the world. In some countries, trademark protection continues as long as the trademark is used. Other countries require registration of trademarks. Registrations are generally for fixed but renewable terms.
Like other major pharmaceutical companies, we grant licenses under patents and know-how developed by us and we manufacture and sell products and use technology and know-how under licenses from others.
Schering AG and Schering-Plough Corporation have entered into an agreement relating to their respective use of the word "Schering". Under this agreement, subject to certain limited exceptions, Schering AG may not use the Schering name for commercial purposes relating to its healthcare business (including pharmaceutical products) in the United States and Canada where we operate our pharmaceutical business under the Berlex trade name, while in the rest of the world our use of the Schering name is unrestricted.
SUPPLIES AND RAW MATERIALS
We purchase raw materials and supplies on a worldwide basis from numerous suppliers. In those cases where only a single supplier is available, we seek to accumulate and maintain a strategic reserve inventory of raw materials and supplies, qualify new suppliers, and develop production processes in our own facilities. We undertake to secure strategic materials through medium- and long-term contracts. We have not experienced difficulties in obtaining sufficient amounts of raw materials and supplies in recent years and we anticipate that we will be able to do so in the future. The price of raw materials and supplies may vary substantially in the future.
The Group's European facilities produce a substantial portion of the active ingredients used for the production of our products in the Europe, United States, Latin America/Canada, Japan and Asia/Middle East Regions. In addition, a number of the active pharmaceutical ingredients of our top-selling products, including Betaferon® (Betaseron®) and Iopamiron®, are manufactured by third parties under long term contracts.
REGULATION
Like other pharmaceutical companies, we are subject to comprehensive government controls on the research, clinical and non-clinical development, manufacture, labeling, advertising, safety reporting, distribution and marketing of our products in all countries of the world. These controls include various and detailed government inspections. We are required to obtain regulatory approval for pharmaceutical products and medical devices before we can market the products in a particular country, according to the applicable national regulations. These approvals must be maintained in order to continue marketing the product. We are in material compliance with applicable governmental regulations in the jurisdictions in which we operate.
For the registration of a pharmaceutical product, evidence establishing the quality, safety and efficacy of the product must be submitted together with information about its identification and the texts for physician and patient information. The evidence of quality is included in the chemical-pharmaceutical documentation and the evidence of safety and efficacy in the pharmacological-toxicological and clinical documentation, all of which is gathered into a registration dossier. A pharmaceutical product generally must be registered in each country in which it will be sold.
The submission of an application to a regulatory authority does not guarantee that approval to market the product will be granted. Although the above-mentioned criteria for the registration of therapeutic and diagnostic products are similar in all countries, the formal structure of the necessary documentation for registration and the attitude of the regulatory authorities to the review of such documents vary significantly from country to country. It is possible that a pharmaceutical product can be registered and marketed in one country and that the registration authority in a neighboring country prior to registration will request additional documents from the pharmaceutical company or even reject the product. The registration process takes between six months and several years depending on the nature of the product, the quality of the data produced, the country-specific legislation and the registration authority. Innovative products of particular therapeutic interest (e.g., treatment of life threatening or disabling diseases) may be processed on an accelerated basis in many countries. The FDA, the Japanese Ministry of Health, Labour and Welfare (Koseirodosho) and the EU authorities have successfully shortened review times and adhere to preset timelines thereby approaching approval times in the range of 12 months. The pharmaceutical development and registration process is typically intensive, lengthy and rigorous. Once a new compound has been identified in the laboratory as a potential candidate drug through a screening process, it undergoes broad pre-clinical testing. During pre-clinical testing, test tube and animal studies are conducted to show biological activity of the compound against the targeted disease, and on (other) body systems to evaluate the whole efficacy and safety range. To begin clinical trials (i.e., tests of the drug in humans), in the United States an investigational new drug application (IND) is filed with the FDA; the IND becomes effective if the FDA does not disapprove it within 30 days. In other countries there are varying but similar requirements before beginning clinical trials. Clinical testing is usually done in three phases which can be followed by phase IV after approval. The size and the duration of clinical trials depend very much on the targeted disease. Following the completion of all three phases of clinical trials, all of the data is analyzed and a new drug application (NDA) for drugs or a biologic license application (BLA) for biologics is filed with the FDA (or its equivalent in other countries) if the data successfully demonstrate safety and efficacy. In the United States, the FDA is required to review and make a recommendation for approval of new drugs within 12 months. For drugs designated as "priority" drugs, the review time is six months.
Once the FDA (or the respective agency in another country) approves the application, the new pharmaceutical becomes available for physicians to prescribe. The pharmaceutical company must continue to submit periodic reports to the agency, including any cases of adverse reactions and appropriate quality-control records. For some medications, additional studies (Phase IV) are required to evaluate long-term effects.
The duration of trials and the vast amount of data that must be collected and evaluated makes clinical testing the most time-consuming and expensive part of new drug development. We have instituted a global system for coordinating this process in order to increase its speed and reduce costs.
Marketed products are reviewed continuously for quality, safety and efficacy. For this, we have established an internal review board. From time to time, we may elect or be required, upon consultation with or at the direction of governmental regulators, to take certain action (e.g. change of product information, recall). In the past such action was required only rarely and has been limited to individual products, and the effect on the Group has not been material.
In addition to the regulations enforced by the FDA (and the respective government agencies in other countries), we are subject to laws regarding environmental protection and hazardous substances that govern our use, handling and disposal of various biological, chemical and radioactive substances used in, and wastes generated by, our operations.
Certain of the products that we market and are developing may be considered biotechnology products. Ethical, social and legal concerns about gene therapy, genetic testing and genetic research could also result in additional regulations restricting or prohibiting the processes we or our suppliers may use. Various governments have expressed interest in further regulating biotechnology. More restrictive regulations or claims that such products are unsafe or pose a hazard could prevent or delay the continued sale or commercialization of such products.
In addition to the normal competitive forces that affect the level of pharmaceuticals prices, a further constraint exists in the form of governmental intervention such as price or profit controls, budgets or patient contribution requirements in most countries in which the Group sells its products. These controls arise either by law or because the government or other health care providers in a particular jurisdiction are the principal purchasers of the product or reimburse purchasers of the product for all or a portion of the cost of the product. Price control mechanisms operate differently from jurisdiction to jurisdiction and can result in large price differentials between markets. These differentials may be increased by currency fluctuations and the intensity of competition in specific markets, since not all drugs are authori zed in every market.
We cannot predict with certainty what future effects various pharmaceutical cost control efforts will have on our business. These efforts could have significant adverse consequences for the pharmaceutical industry as a whole and consequently also for the Group. Increasing budgeting and price controls, the inclusion of patent protected drugs in a fixed price system and lists for the rational use of drugs as well as legislation permitting or requiring a dispensing pharmacist to substitute another version of the pharmaceutical product for the one prescribed may occur in the future.
ORGANIZATIONAL STRUCTURE
Schering AG is the parent company of the Schering AG Group. The Group is comprised of over 140 subsidiaries worldwide.
The following table sets forth, by geographic segment, as of December 31, 2003, the name, jurisdiction of incorporation, and ownership interest and voting interest held in, of Schering AG's principal operating subsidiaries.
Europe Region: | | |
---|
Company | Jurisdiction | Percentage of ownership and voting interest |
---|
Jenapharm GmbH & Co. KG | Germany | 100.0 |
Schering Deutschland GmbH | Germany | 100.0 |
N.V. Schering S.A. | Belgium | 100.0 |
Schering Oy | Finland | 100.0 |
CIS bio international S.A. | France | 100.0 |
Schering S.A. | France | 99.9 |
Schering Health Care Ltd. | Great Britain | 100.0 |
Schering S.p.A. | Italy | 100.0 |
Schering Nederland B.V. | Netherlands | 100.0 |
Schering Wien Ges. m.b.H. | Austria | 100.0 |
Schering Lusitana Lda. | Portugal | 100.0 |
Schering (Schweiz) AG | Switzerland | 100.0 |
Schering España S.A. | Spain | 99.9 |
Schering Alman Ilaç ve Ecza Ticaret Ltd. | Turkey | 100.0 |
Schering (Pty.) Ltd. | South Africa | 100.0 |
Schering Pty. Ltd. | Australia | 100.0 |
United States Region: | | |
---|
Company | Jurisdiction | Percentage of ownership and voting interest |
---|
Schering Berlin Inc. | United States | 100.0 |
Berlex Inc. | United States | 100.0 |
Medrad, Inc. | United States | 100.0 |
Japan Region: | | |
---|
Company | Jurisdiction | Percentage of ownership and voting interest |
---|
Nihon Schering K.K. | Japan | 100.0 |
Latin America/Canada Region: | | |
---|
Company | Jurisdiction | Percentage of ownership and voting interest |
---|
Berlex Canada Inc. | Canada | 100.0 |
Schering Argentina S.A.I.C. | Argentina | 100.0 |
Schering do Brasil Ltda. | Brazil | 100.0 |
Schering Colombiana S.A. | Colombia | 100.0 |
Schering Mexicana S.A. | Mexico | 100.0 |
Asia/Middle East Region: | | |
---|
Company | Jurisdiction | Percentage of ownership and voting interest |
---|
Schering Pharmaceutical Ltd. | China | 100.0 |
P.T. Schering Indonesia | Indonesia | 85.0 |
Schering (Korea) Ltd. | South Korea | 100.0 |
Schering Taiwan Ltd. | Taiwan | 100.0 |
Schering (Bangkok) Ltd. | Thailand | 100.0 |
PROPERTY, PLANTS AND EQUIPMENT
Schering AG's principal executive offices are located in Berlin, Germany.
We produce active pharmaceutical ingredients at 5 locations in 4 countries including our primary facility in Bergkamen, Germany, and several smaller facilities in Germany, Finland, Spain and Mexico.
In addition to these production operations, we operate 19 principal production facilities in 15 countries for the formulation and packaging of pharmaceutical, radiopharmaceutical and biotechnological products.
We also own or lease other properties used for administration, research and development, marketing and sales and warehouses.
We believe that our manufacturing and production facilities have capacities adequate for our current and projected needs.
For information regarding our capital expenditure program, see "Group Organization- Group Segments-Europe Region-Capital Expenditures", "-United States Region-Capital Expenditures", "-Latin America/Canada Region-Capital Expenditures", "-Japan Region-Capital Expenditures" and "-Asia/Middle East Region-Capital Expenditures", and "Item 5-Operating and Financial Review and Prospects-Liquidity and Capital Resources-Capital Expenditures".
The following table sets forth, by segment, the location, approximate size and use of our production, distribution and other facilities. These facilities are owned unless otherwise indicated. Administration offices comprise functions such as finance, marketing, sales and medical departments.
Location | Size (square meters)(1) | | Principal uses |
---|
Europe Region: | | | |
Berlin-Wedding, Germany | 184,000 | | Production, research and development and offices |
Berlin-Charlottenburg, Germany(2)(4) | 32,800 | | Production |
Bergkamen, Germany | 958,000 | | Production and offices |
Hamburg, Germany | 8,000 | | Production and offices |
Jena, Germany | 16,500 | | Research and development and offices |
Weimar, Germany | 63,800 | | Production and warehousing |
Saclay, France | 63,000 | | Production and research and development |
Marcoule, France | 46,000 | | Production |
Lys-Lez-Lannoy, France(3) | 60,000 | | Production, warehousing and offices |
Madrid, Spain | 13,000 | | Offices |
Alcalá de Henares, Spain | 30,000 | | Production and offices |
Milan, Italy | 39,000 | | Production and offices |
Turku, Finland(2) | 155,000 | | Production and research and development |
Tikkakoski, Finland | 1,100 | | Production and offices |
United States Region: | | | |
Montville, New Jersey(4) | 21,000 | | Offices |
Wayne, New Jersey(4) | 24,000 | | Production, development, warehousing and offices |
Richmond, California(4) | 31,000 | | Research and development, warehousing and offices |
Indianola, Pennsylvania(4) | 38,600 | | Production, research and development, warehousing and offices |
Pittsburgh, Pennsylvania(4) | 14,400 | | Production, warehousing and offices |
Bedford, Massachusetts(4) | 3,500 | | Production, development and offices |
Seattle, Washington(2)(4) | 3,100 | | Production and offices |
Bothell, Washington(2)(4) | 7,900 | | Production, warehouse, offices |
Japan Region: | | | |
Osaka City, Japan | 26,000 | | Production, research and development, warehousing and offices |
Mobara City, Japan | 39,800 | | Production, research and development, warehousing |
Sakura City, Japan | 10,000 | | Production, development |
Latin America/Canada Region: | | | |
Orizaba, Veracruz, Mexico | 152,100 | | Production, development, warehousing and offices |
Bogotá, Colombia | 9,300 | | Production, warehousing and offices |
São Paulo, Brazil | 10,700 | | Production, warehousing and offices |
Buenos Aires, Argentina | 10,200 | | Production, warehousing and offices |
Asia/Middle East Region: | | | |
Ansung, South Korea | 17,000 | | Production |
Jakarta, Indonesia | 19,000 | | Production, warehousing and offices |
Guangzhou, China | 20,000 | | Production |
Nanjing, China | 4,800 | | Production, warehousing and offices |
(1) This measure corresponds to the size of the land if not indicated otherwise. (2) Subject to a lease. (3) A portion of this facility is subject to a lease. (4) Floor space/office space.
|
ENVIRONMENTAL AND SAFETY MATTERS
In the normal course of our business, we are exposed to the risk of possibly releasing pollutants into the environment that could cause personal injury or property damage, and that could entail substantial clean-up measures. We are subject to extensive regulation in the fields of quality and environmental, health and safety matters in the countries where we manufacture and sell our products. We expect such regulations to become increasingly stringent in the future. Changes in applicable laws repeatedly require us to install additional emission controls, make significant alterations to our manufacturing processes, or clean-up local contamination at facilities. Environmental regulations could also impact our business by restricting or prohibiting the distribution of our current products and forcing us to increase research and development spending.
We have obtained all material quality, environmental and safety permits and authorizations required for the operation of our facilities and the distribution of our products. We are in material compliance with the relevant environmental, health and safety laws. The maintenance of high standards of protection and performance in these areas forms an integral part of our operations. With our internal audit systems and our participation in our industry’s Responsible Care program, we aim at continuous improvements in these areas.
We are responsible for cleaning up certain sites that have been contaminated by the release or disposal of pollutants from former operations. In some cases, this liability is shared with others who are responsible for the contamination or their successors to rights and obligations. Given our long history as a manufacturing enterprise, there may be other sites where we would be obliged to take over part or all of the clean-up costs.
We believe that we have adequate reserves for those remediation obligations currently known to us, and that these will not have a material adverse effect on our operating profit, our liquidity, or the Group’s overall financial position.
We have spent substantial amounts on environmental protection and safety measures up to now, and anticipate having to spend similar sums in 2004 and subsequent years. In 2003, our operating and maintenance costs in the field of environmental protection and safety totaled €76m (2002: €74m). Our capital expenditure on environmental protection projects and other ecologically beneficial projects totaled €15m (2002: €15m).
We estimate that operating and maintenance costs for safety and environmental measures will rise to between €76m and €80m annually by 2008. We expect capital expenditure on environmental projects and other ecologically beneficial projects to be between €5m and €15m annually over the same period.
Table of Contents
You should read the following operating and financial review of our results of operations and financial condition together with our Consolidated Financial Statements included elsewhere in this annual report.
INTRODUCTION
Accounting Policies
We prepared our Consolidated Financial Statements in accordance with the International Financial Reporting Standards (IFRS) of the International Accounting Standards Board. Standards which were issued before April 1, 2001 are designated as International Accounting Standards (IAS). IFRS differ in certain material respects from United States Generally Accepted Accounting Principles. You can read about some of the principal differences in Note 37 to our Consolidated Financial Statements. Note 37 to our Consolidated Financial Statements also provides a reconciliation of our Consolidated Financial Statements to United States Generally Accepted Accounting Principles. For a discussion of the accounting policies we consider to be critical, see "-Results of Operations-Critical Accounting Policies".
We do not utilize commodity contracts. For a detailed discussion of our use of exchange-traded and over-the-counter derivative financial instruments to reduce currency and interest-rate risk resulting from anticipated transactions and from existing assets and liabilities, see “Item 11 – Quantitative and Qualitative Disclosures about Market Risk" and Note 31 to our Consolidated Financial Statements.
Segment reporting
The segment information reported in Note 33 to our Consolidated Financial Statements is presented in accordance with IAS 14 (revised). As required by IAS 14 (revised), our primary basis of segment reporting is geographic, which reflects the management structure of our sales organization, our system of internal financial reporting and what we believe to be the predominant source and nature of risks and returns of our business. Our segment reporting is comprised of five geographic segments (Europe Region, United States Region, Japan Region, Latin America/Canada Region, Asia/Middle East Region). Other Activities (primarily our pharmaceutical chemicals business) are managed and reported on a worldwide basis and are therefore presented as a separate segment.
RESULTS OF OPERATIONS
Overview
The following table sets forth the net sales, net sales expressed as a percentage of total net sales, and percentage change in net sales from the prior year, the segment performance, segment performance expressed as a percentage of total segment performance and percentage change in segment performance from the prior year, and the segment result, segment result expressed as a percentage of total segment result and percentage change in segment result from the prior year, for each of the Group's segments for the three years ended December 31, 2003, 2002, 2001. As discussed in Note 33 to our Consolidated Financial Statements:
Segment performance is an internal financial reporting measurement utilized by our management. Transfers from our centralized production facilities in Europe are charged to segments at standard production cost. Research and development expenses are not included in segment performance because research and development activities are managed on a worldwide basis.
To determine segment result for a segment, we subtract an allocation of research and development expenses and central production overhead and production variances from segment performance.
To determine total operating profit for the Group, we subtract certain items (such as costs of corporate functions and other operating income and expenses) from the total segment result.
| Year ended December 31, |
---|
| 2003 | | 2002 | | 2001 |
---|
| € | % of segment total | Percentage change from 2002 | € | % of segment total | Percentage change from 2001 | € | % of segment total |
---|
| (in million, except percentages) |
---|
Net Sales: | | | | | | | | |
Europe Region* | 2,387 | 49 | 1 | 2,357 | 47 | 8 | 2,183 | 45 |
United States Region | 1,203 | 25 | (6) | 1,282 | 25 | 15 | 1,113 | 23 |
Japan Region | 517 | 11 | (11) | 579 | 12 | (13) | 663 | 14 |
Latin America/Canada Region | 383 | 8 | (11) | 430 | 9 | (16) | 511 | 11 |
Asia/Middle East Region | 199 | 4 | (11) | 224 | 4 | 5 | 213 | 4 |
Other Activities | 139 | 3 | (8) | 151 | 3 | (4) | 159 | 3 |
Total net sales | 4,828 | 100 | (4) | 5,023 | 100 | 4 | 4,842 | 100 |
Segment performance: | | | | | | | | |
Europe Region* | 1,031 | 55 | (1) | 1,040 | 54 | 13 | 922 | 51 |
United States Region | 394 | 21 | 8 | 366 | 19 | 16 | 315 | 17 |
Japan Region | 202 | 11 | (12) | 229 | 12 | (6) | 244 | 14 |
Latin America/Canada Region | 137 | 7 | (4) | 143 | 7 | (16) | 170 | 9 |
Asia/Middle East Region | 68 | 3 | (17) | 82 | 4 | 14 | 72 | 4 |
Other Activities | 57 | 3 | (24) | 75 | 4 | (6) | 80 | 5 |
Total segment performance | 1,889 | 100 | (2) | 1,935 | 100 | 7 | 1,803 | 100 |
Central production overhead/variances | (162) | | 14 | (142) | | 4 | (136) | |
Research and development | (924) | | (2) | (947) | | 10 | (864) | |
Segment result | 803 | | (5) | 846 | | 5 | 803 | |
Segment result: | | | | | | | | |
Europe Region* | 532 | 66 | (3) | 548 | 65 | 19 | 460 | 57 |
United States Region | 125 | 16 | 20 | 104 | 12 | 44 | 72 | 9 |
Japan Region | 88 | 11 | (17) | 106 | 13 | (1) | 107 | 14 |
Latin America/Canada Region | 50 | 6 | 16 | 43 | 5 | (55) | 95 | 12 |
Asia/Middle East Region | 14 | 2 | (52) | 29 | 3 | (19) | 36 | 4 |
Other Activities | (6) | (1) | (138) | 16 | 2 | (52) | 33 | 4 |
Total segment result | 803 | 100 | (5) | 846 | 100 | 5 | 803 | 100 |
Other | (117) | | 11 | (105) | | (22) | (135) | |
Total operating profit | 686 | | (7) | 741 | | 11 | 668 | |
* incl. Africa, Australia and New Zealand |
The following table sets forth the net sales, net sales expressed as a percentage of total net sales, and percentage change in net sales from the prior period for the Group's business areas for the three years ended December 31, 2003, 2002, 2001. In 2002, the business area Fertility Control&Hormone Therapy was renamed Gynecology&Andrology to reflect our focus on specific healthcare solutions for women and men.
| Year ended December 31, |
---|
| | 2003 | | | 2002 | | | 2001 |
---|
| € | Percentage of net sales | Percentage change from 2002 | € | Percentage of net sales | Percentage change from 2001 | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales by Business Area: | | | | | | | | |
Gynecology&Andrology | 1,622 | 34 | 1 | 1,613 | 32 | 7 | 1,510 | 31 |
Specialized Therapeutics | 1,560 | 32 | (5) | 1,637 | 33 | 10 | 1,491 | 31 |
Diagnostics&Radiopharmaceuticals | 1,312 | 27 | (7) | 1,406 | 28 | (3) | 1,452 | 30 |
Dermatology | 200 | 4 | (7) | 217 | 4 | (5) | 227 | 5 |
Other sources | 134 | 3 | (10) | 150 | 3 | (7) | 162 | 3 |
Total | 4,828 | 100 | (4) | 5,023 | 100 | 4 | 4,842 | 100 |
2003 Compared to 2002
Group
Consolidated Income Statements | 2003 | 2002 |
---|
| € | % of net sales | € | % of net sales |
---|
| (in million, except percentages) |
---|
Net sales | 4,828 | 100 | 5,023 | 100 |
Cost of sales | (1,233) | 26 | (1,212) | 24 |
Gross profit | 3,595 | 74 | 3,811 | 76 |
Marketing and selling costs | (1,525) | 32 | (1,629) | 32 |
Engineering and administration costs | (566) | 12 | (566) | 11 |
Research and development costs | (924) | 19 | (947) | 19 |
Other operating income | 399 | | 370 | |
Other operating expenses | (293) | | (298) | |
Operating profit | 686 | 14 | 741 | 15 |
Financial result | 15 | | (23) | |
Income from disposal of Aventis CropScience | – | | 689 | |
Acquisition-related expenses | – | | (262) | |
Profit from ordinary activities | 701 | 15 | 1,145 | 23 |
Income taxes | (255) | 5 | (276) | 5 |
Net profit before minority interest | 446 | 9 | 869 | 17 |
Minority interest | (3) | | (2) | |
Net profit | 443 | 9 | 867 | 17 |
The following table sets forth our top-selling products during 2003. These products represented approximately 54% of the total net sales for the Group in 2003:
Top-selling products | Net sales | Percentage change from 2002 |
---|
| (€million) | total | currency adjusted |
---|
1. Betaferon® (Betaseron®) (therapeutics) | 770 | (2) | 8 |
2. Magnevist® (diagnostics) | 300 | (7) | 5 |
3. Yasmin® (fertility control) | 290 | 91 | 115 |
4. Iopamiron® (diagnostics) | 263 | (12) | (2) |
5. Ultravist® (diagnostics) | 236 | (2) | 4 |
6. Diane® (gynecology) | 202 | (10) | (4) |
7. Mirena® (fertility control) | 164 | 20 | 29 |
8. Fludara® (therapeutics) | 140 | (6) | 5 |
9. Microgynon® (Levlen®) (fertility control) | 122 | (6) | 7 |
10. Meliane® (fertility control) | 119 | (6) | 1 |
Total | 2,606 | 2 | 12 |
Net sales
The following table sets forth our net sales by geographic segment during 2003 and 2002, the total change in net sales for each of the geographic segments and the Group reported in the Consolidated Financial Statements and an allocation of such changes among volume/price effects, currency effects and structure effects (effects from acquisitions and divestitures of businesses and products). In the accompanying discussion of net sales of the Group and by geographic segment, in addition to providing net sales figures reported in euro in accordance with IFRS, we sometimes provide net sales figures for a region, country, business area or product in local currencies or an organic basis. This disclosure is provided in order to assist investors in making comparisons from period to period and to understand underlying trends in our net sales that may not be a pparent.
Net sales by Region | € | Percentage change from 2002 | % of net sales |
---|
| 2003 | 2002 | total | volume/price | currency | structure* | 2003 | 2002 |
---|
| (in million, except percentages) |
---|
Europe Region | 2,387 | 2,357 | 1 | 5 | (1) | (3) | 49 | 47 |
United States Region | 1,203 | 1,282 | (6) | 10 | (19) | 3 | 25 | 25 |
Japan Region | 517 | 579 | (11) | (1) | (10) | 0 | 11 | 12 |
Latin America/Canada Region | 383 | 430 | (11) | 15 | (26) | 0 | 8 | 9 |
Asia/Middle East Region | 199 | 224 | (11) | (1) | (10) | 0 | 4 | 4 |
Other Activities | 139 | 151 | (8) | (5) | (3) | 0 | 3 | 3 |
Total | 4,828 | 5,023 | (4) | 6 | (9) | (1) | 100 | 100 |
* Effects from acquisitions and divestitures
|
Net sales represents the gross inflow of economic benefits received and receivable by the Group on its own account from the sales of goods and services. Sales rebates and discounts as well as amounts collected on behalf of third parties such as sales taxes and goods and services taxes are excluded from net sales.
In 2003, the Schering AG Group generated organic sales growth of 6%, mainly due to increased sales volumes. Net sales were negatively impacted by the continued strength of the euro of 9% and by structure effects of 1%. In euros, net sales therefore decreased by 4% to €4,828m.
Net sales in the Gynecology&Andrology business area increased by 11% in local currencies This was particularly due to the increase of 16% (total +6%) in the field of fertility control, with Yasmin® sales more than doubling in 2003 in local currencies. Reaching total net sales of €290m, Yasmin® is now the Group’s third-largest product. In addition, Mirena® recorded an above-average increase in net sales of 29% in local currencies (total +20%). In contrast, net sales in our hormone therapy business decreased by 8% currency adjusted (total –18%). Despite negative exchange rate effects (–10%), total net sales in the Gynecology&Andrology business area rose by 1% to €1,622m.
Specialized Therapeutics business area recorded an organic sales growth of 5%. Considering negative exchange rate and structure effects, total net sales decreased by 5% to €1,560m. The net structure effect includes Leukine® sales in the first half of 2003 (€32m) and the sale of non-core products (€–50m). Organic growth in the Specialized Therapeutics business area was primarily driven by the increase in net sales of Betaferon®, Campath® (marketed outside of the U.S. under the trade name MabCampath®), and Fludara®. Net sales of Betaferon® amounted to €770m (+ 8% currency adjusted; total –2%). This solid growth was facilitated by the continuous improvement of Betaferon®, increasing user-friendliness for patients. In 2003, our cancer therapy Campath® recorded an increase in net sales to €63m compared with €46m in 2002. This positive effect was partly due to combining Campath® and Fludara® as a new therapy option. In the case of Fludara®, which lost its patent protection in the U.S. in August 2003, positive volume/price effects resulted in a net sales increase of 5% in local currencies (total –6%).
In the Diagnostics&Radiopharmaceuticals business area, net sales in 2003 increased by 4% in local currencies. Negative currency effects of 11% led to a decline in euro terms in net sales of 7% to €1,312m. In the field of X-ray contrast media, lower prices (–4%) were compensated by an increase in sales volume of 4%. Net sales in the field of magnetic resonance imaging (MRI) contrast agents increased by 8% in local currencies (total –4%). This was driven by increased net sales of Magnevist® and substantial gains on our new products Gadovist® and Resovist®. In 2003, we recorded a currency adjusted growth rate of 15% (total –4%) in application technologies for contrast agents. Since our application technologies business is managed centrally from the United States, we allocate global sales of the Medrad Group to the United States Region. Due to the translation to euro, this led to a negative exchange rate effect of 19%.
In the Dermatology business area, we recorded an organic growth of 3%. Our top-selling products in this Business Area – Advantan®, Skinoren®, and Travocort® – made an above-average contribution to this increase. Currency effects and the divestiture of the general practitioner business of former Asche AG in 2002 resulted in an overall decrease in net sales of 7% to €200m.
Gross profit
Gross profit represents net sales after cost of sales. Cost of sales includes the production costs of goods sold and the purchased cost of goods for resale.
Gross profit declined by 6% from €3,811m in 2002 to €3,595m in 2003. This decline exceeded the decrease in net sales of 4%. This was mainly due to the fact that a large portion of our production is accounted for in euro. The negative impact of the continuing strength of the European currency on net sales is therefore stronger than the currency-related decrease in production costs, occurring outside the euro zone.
Operating profit
Operating profit represents gross profit after marketing and selling costs, engineering and administration costs, research and development costs and other operating income and expenses. Engineering and administration costs include costs of production management and planning, environmental protection, technology cost centers such as workshops, energy production, services and waste disposal (only to the extent that these costs are not internally reallocated to the consuming functions), training, and general administration such as human resources, purchasing, controlling and accounting.
At €686m, operating profit was down 7% on the previous year’s figure. Marketing and selling costs declined to a greater extent (–6%) than net sales. Engineering and administration costs were flat year-on-year at €566m. Research and development costs decreased by 2% to €924m (2002: €947m). Their ratio to net sales remained stable, at 19%. The improvement in net Other operating income and expenses in the amount of €34m was mainly due to greater gains from exchange rate hedges.
Financial result
Financial result represents result from investments, interest result and other financial result.
The financial result improved by €38m compared to 2002. This was due, among other things, to lower write-downs on investments (€7m) as compared to the previous year (€26m). In addition, the absence of income from our share in the result of Aventis CropScience (2002: €45m) was partially offset by the profit from the sale of our interest in Oy Leiras Finland AB (€22m).
Income taxes
Income taxes declined from €276m to €255 in fiscal year 2003. The increase in the effective tax rate to 36%, up from 24% in 2002, is primarily due to tax-free income from the disposal of our interest in Aventis CropScience in 2002.
Net profit
Net profit decreased from €867m in 2002 to €443m in 2003. Basic earnings per share amounted to €2.28, down from €4.39 in 2002. As described below, the decrease in net profit and basic earnings per share is primarily due to the one-time effects in 2002 of the disposal of our 24% interest in Aventis CropScience, acquisition-related expenses of €262m and tax-related effects.
We believe that our net profit and basic earnings per share for 2002 were impacted by several significant non-recurring items, the effect of which may impair the ability of investors to make comparisons of such figures for 2002 with net profit and basic earnings per share for 2003. In order to improve the ability of investors to make a comparison of these figures for 2002 and 2003, set forth below is a table that includes (i) net profit and basic earnings per share for 2002 and 2003 as reported under IFRS, (ii) net profit and basic earnings per share for 2002 after being adjusted for these non-recurring items, and (iii) a reconciliation of net profit and basic earnings per share from an as reported under IFRS basis to an adjusted basis for 2002.
| 2003 | 2002 | Percentage change |
---|
| (€million; per share amounts in €) |
---|
Net profit ( IFRS) | 443 | 867 | (49) |
Income from disposal of Aventis CropScience | – | (689) | – |
Acquisition-related expenses | – | 262 | – |
One-time tax effects | – | 24 | – |
Net profit on a comparable basis | 443 | 464 | (5) |
Basic earnings per share (IFRS) | 2.28 | 4.39 | (48) |
Basic earnings per share on a comparable basis | 2.28 | 2.35 | (3) |
The €689m of income from the disposal of our 24% interest in Aventis CropScience relates to the €1,500m of proceeds less the carrying amount of €526m and indemnities of €285m.
The acquisition-related expenses of €262m in 2002 related to €224m for the acquisition of the rights to the Phase II-development project for the use of Leukine® in Crohn's disease, to €20m for the formation of the Schering Stiftung (a foundation under German law) for the promotion of science and culture, and to €18m for adjustments of the carrying amounts of assets and liabilities in connection with the acquisition of the 60% interest in CIS bio international in 2000. One-time tax effects of €24m in 2002 related to the income from the disposal of Aventis CropScience and the acquisition-related expenses as well as tax risks.
Results of Operations by Segment
Net sales, segment performance and segment result of each of our geographic segments and our Other Activities segment are presented in Note 33 to our Consolidated Financial Statements and in accordance with IAS 14 (revised).
Europe Region
The geographic segment referred to in this annual report as the Europe Region comprises the member states of the European Union, all other countries in continental Europe, Turkey, the countries making up the Commonwealth of Independent States, South Africa, Australia, New Zealand, and our African export markets (excluding Egypt and Libya). Net sales for the Europe Region also include global net sales by the Group companies Schering Oy (formerly Leiras Oy), Jenapharm, CIS bio international, and the Justesa Imagen Group. Germany, France, Great Britain, Italy, and Spain were the five strongest sales markets in this region in the period under review, accounting for 62% of net sales generated in this segment in 2003.
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Europe Region for the years ended December 31, 2003 and 2002:
Net sales in the Europe Region by business area: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Gynecology&Andrology | 971 | 921 | 5 | 41 | 39 |
Specialized Therapeutics | 835 | 843 | (1) | 35 | 36 |
Diagnostics&Radiopharmaceuticals | 449 | 450 | 0 | 19 | 19 |
Dermatology | 125 | 132 | (5) | 5 | 6 |
Other sources | 7 | 11 | (38) | 0 | 0 |
Total | 2,387 | 2,357 | 1 | 100 | 100 |
Net sales
Net sales in the Europe Region increased by 1% to €2,387m in 2003. The rise was due to positive price and volume effects (+5%), compared to negative structure effects (–3%) and exchange rate effects (–1%). The structure effects include the divestiture of the general practitioner division of AWAG Arzneimittelwerke Altona AG (formerly Asche AG) in Germany in 2002, as well as the sale of the non-strategic domestic portion of our Finnish operations. Overall, net sales in the Europe Region were impacted by increasing governmental price control and intensified competition from generic products, especially in Germany, France and Italy.
Net sales increased in our major markets, with the exception of Germany. In Germany, net sales declined by 5% to €544m in 2003, primarily as a result of the divestiture (–2%) as well as negative price effects due to cost-cutting measures in the healthcare sector (–2%). In contrast, net sales in Great Britain rose by 4% (+14% currency adjusted), mainly due to substantial increases in volumes of Yasmin®, Diane® and Betaferon®. Net sales in Spain rose by 3% (+4% currency adjusted) due to the launch of Yasmin® and increased sales volumes of Betaferon®. The growth in net sales in France and Italy (+4% each) was also due to increased sales of Yasmin®. In Italy, Yasmin®, within a year of its launch, generated net sales of €19m, or 7% of total net sales for this country. In addition to Great Britain, we recorded double-digit increases in net sales in local currencies for the following European markets: Belgium (+12%; total +12%), Turkey (+21%; total +14%) and Russia (+33%; total +20%) as well as the majority of other Eastern European countries.
In the Gynecology&Andrology business area, we achieved net sales growth of 7% after adjustment for exchange rate effects (total +5%). This was based on increased volumes (+6%), and slightly higher prices (+2%), taking divestiture effects in Germany and Finland (totaling –1%) into account. The positive development in our fertility control business (+11% currency adjusted; total +9%) more than compensated for a decline in sales of our hormone therapy business. Particularly noteworthy are Yasmin®, sales of which more than doubled in 2003 to €115m, and the double-digit increases in net sales in local currencies recorded by Mirena® (+20%; total +18%) and Microgynon® (+11%; total +6%).
After adjustment for exchange rate effects, net sales in the Specialized Therapeutics business area remained at last year’s level (total –1%). Sales volumes increased by 10% in 2003, but were offset by negative price effects (–4%) and divestiture effects in Germany and Finland (totaling –6%). The increase in net sales in local currencies was due particularly to Betaferon® (+10%; total +8%), Fludara® (+19%; total +16%), and MabCampath® (+22%; total +20%). Net sales of Bonefos® decreased by 4% currency adjusted (total –5%), due to the sharp decline in prices caused by competition from generic products.
Net sales in the Diagnostics&Radiopharmaceuticals business area increased by 2% in 2003 after adjustment for exchange rate effects (total 0%). Higher sales volumes (+4%) more than offset lower prices (–2%). This was due above all to developments of our two core products – Magnevist® and Ultravist® – which jointly accounted for 54% of net sales in this Business Area. Net sales of Ultravist® climbed 2% after adjustment for exchange rate effects (total –1%), while we recorded a 4% rise in net sales of Magnevist®, also currency adjusted (total +3%). Net sales of radiopharmaceuticals increased by 2% after adjustment for exchange rate effects (total +2%).
The Dermatology business area recorded a decrease in net sales of 3% in local currencies (total –5%) in 2003. This was due to divestiture effects in Germany, which impacted this Business Area by 4%. Organic growth of 1% was the result of positive developments of Advantan® and Travocort®, which compensated the decline of Psorcutan®.
Segment performance/Segment result
Segment performance declined by 1% to €1,031m in 2003. This was due to a decrease in gross profit, which was mainly the result of the impact of the German healthcare reform. This negative effect was offset by a reduction in overheads, especially a reduction in marketing and selling costs as well as administration costs.
After allocation of €426m of research and development costs and €73m of central production overhead/variances, the segment result in 2003 was €532m, representing a slightly lower segment result as compared to €548m in 2002. This decrease was mainly due to the reduced segment performance as well as to higher allocated production overheads.
United States Region
The geographic segment referred to in this annual report as the United States Region comprises the United States of America and Puerto Rico. The segment is divided into two subsegments. The Berlex subsegment covers all sales of pharmaceutical products in the United States Region generated by Berlex Inc. The second subsegment covers the business activities of the Medrad Group, which is active in the field of application technologies for contrast agents. Since Medrad is responsible for the global marketing of its products, this subsegment represents global net sales by Medrad and its subsidiaries.
The following table sets forth the net sales by sub-segment, and net sales by sub-segment expressed as a percentage of total net sales, of the United States Region for the years ended December 31, 2003 and 2002:
Net sales for United States Region by sub-segment: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Berlex | 951 | 1,019 | (7) | 79 | 79 |
Medrad | 252 | 263 | (4) | 21 | 21 |
Total | 1,203 | 1,282 | (6) | 100 | 100 |
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the United States Region, for the years ended December 31, 2003 and 2002:
Net sales for United States Region by business area: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Gynecology&Andrology | 271 | 252 | 8 | 23 | 19 |
Specialized Therapeutics | 500 | 561 | (11) | 41 | 44 |
Diagnostics&Radiopharmaceuticals | 423 | 460 | (8) | 35 | 36 |
Dermatology | 9 | 9 | 3 | 1 | 1 |
Total | 1,203 | 1,282 | (6) | 100 | 100 |
Net sales
Net sales in the United States Region declined by 6% to €1,203m in 2003, due to the sharp drop in the U.S. dollar compared to 2002. However, net sales rose by 13% after adjustment for exchange rate effects. Besides an increase in prices (+3%), this growth was particularly due to strong volume growth. In addition, 3% of the increase relates to sales of Leukine® in the first half of 2003 that are reported as structure effect.
Berlex accounted for €951m or 79% of total net sales in the United States Region in 2003, while Medrad contributed €252m, or 21%. After adjustment for exchange rate effects, Medrad’s net sales rose by 15% (total –4%), due to increased sales volumes of CT injection systems (+20%) and services (+24%). The United States Region generated €173m (69%) of Medrad’s global sales in 2003, up from 68% in 2002.
Net sales in the Specialized Therapeutics business area, which accounted for approximately 53% of Berlex’s net sales, rose by 7% in local currency (total –11%) in the year under review. This increase is due in particular to an increase in net sales of Leukine® from €33m in 2002 to €64m in 2003. Betaseron®, our best-selling product in this Region (€286m), recorded net sales growth of 2% after adjustment for exchange rate effects (total –15%). Net sales of Campath® amounted to €47m in 2003, up from €33m in 2002 (+69% currency adjusted; total +41%). This is due to the fact that Campath® is being used more often and at an earlier stage in the treatment of chronic lymphocytic leukemia. However, net sales of Fludara®, another cancer therapy, declined by 10% after adjustment for exchange rate effects (total –25%), following the expiration of our patent for fludarabine phosphate in the U.S. in August 2003. Net sales of Betapace®, the market exclusivity of which expired in the United States in April 2000, continued to decline, decreasing to €26m in 2003.
Net sales in the Diagnostics&Radiopharmaceuticals business area increased by 10% in 2003 after adjustment for exchange rate effects (total –8%). Excluding Medrad, net sales rose by 4% after adjustment for exchange rate effects (total –13%). Negative price effects of 3% were overcompensated by volume increases of 7%. The crucial factor for this increase in net sales was the development of Magnevist® (+9% currency adjusted, total –9%). The increased use of Magnevist® in MRI scans clearly could be seen from the rise in volumes (+12%).
Our Gynecology&Andrology business area recorded strong sales growth of 30% after adjustment for exchange rate effects (total +8%). This increase was primarily due to the continued excellent development of Yasmin®: net sales of this product almost doubled in local currency (total +60%) and accounted for €152m of net sales. Therefore, Yasmin® is our second strongest product in this Region. Mirena® generated net sales of €45m in 2003, up 54% after adjustment for exchange rate effects (total +28%). This positive development is partly due to its inclusion in additional reimbursement support programs. In our hormone therapy business, in contrast, positive price effects for Climara® (+4%) only partially offset lower sales volumes (–14%).
Net sales in the Dermatology business area, which we are further developing in this Region, amounted to €9m in the year under review, an increase of 24% after adjustment for exchange rate effects (total +3%). This growth was due to the market launch of Finacea™, a product used in the treatment of rosacea.
Segment performance/Segment result
Segment performance improved by 8% to €394m in 2003. Negative currency effects, that lead to a decline in net sales, were partly offset by positive currency effects concerning overhead costs. In local currency, marketing and selling costs showed a single-digit percentage increase, whereby this increase remained below the net sales growth in local currency. Gross profit slightly decreased in percentage, because part of the production costs are accrued in euro. Products with higher gross profits, such as Yasmin®, could partially compensate for this currency related deterioration.
After allocation of €254m of research and development costs and €15m of central production overhead/variances, segment result in 2003 increased by 20% to €125m in 2003, compared to €104m in 2002. This sharp increase was primarily driven by the improved segment performance. Due to our strategic commitment to significantly expand our business in the United States, research and development expense as a percentage of net sales, was above the average percentage in the Schering AG Group.
Japan Region
The geographic segment referred to in this annual report as the Japan Region covers the geographical territory of Japan, including the business generated by our Japanese subsidiaries and direct sales by Schering AG to Japanese pharmaceutical companies.
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Japan Region for the years ended December 31, 2003 and 2002:
Net sales for Japan Region by business area: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Gynecology&Andrology | 28 | 30 | (8) | 5 | 5 |
Specialized Therapeutics | 117 | 129 | (9) | 23 | 22 |
Diagnostics&Radiopharmaceuticals | 342 | 386 | (11) | 66 | 67 |
Dermatology | 30 | 34 | (11) | 6 | 6 |
Total | 517 | 579 | (11) | 100 | 100 |
Net sales
Net sales in the Japan Region declined in 2003 by 11% to €517m, due in particular to the strength of the euro against the yen. After adjustment for exchange rate effects, net sales declined by 1%, with increased sales volumes (+2%) almost offsetting government imposed price reductions (–3%).
Net sales in the Diagnostics&Radiopharmaceuticals business area, which accounted for 66% of net sales in this Region in the year under review, declined by 2% currency adjusted (total –11%). The primary reason for this decrease was a decline in net sales of the X-ray contrast medium Iopamiron® (–3%; total –13%), related to a price decrease. This product accounted for €227m (66%) of net sales in this Business Area in 2003. In the case of Ultravist®, the drop in prices (–15%) was almost compensated by increased sales volumes (+14%).
The Specialized Therapeutics business area recorded a slight increase in net sales of 1% after adjustment for exchange rate effects (total –9%), with volume growth (+2%) overcompensating the slight negative price effect (–1%). Net sales of Betaferon®, our third-strongest product in Japan in 2003, increased to €25m (+23% currency adjusted; total +10%).
The Gynecology&Andrology business area recorded sales growth of 3% currency adjusted (total –8%). Triquilar® further expanded our market leadership position in the field of fertility control with an increase in sales volumes of €2m in 2003.
In the Dermatology business area, net sales in local currency remained at previous year’s level (total –11%), with stable prices and almost constant sales volumes for our top-selling products, Neriproct® and Nerisona®.
Segment performance/Segment result
Segment performance declined by 12% to €202m in 2003. Consequently, the percentage decrease of the segment performance was slightly higher than the decline in net sales. This was due to the slightly decreased gross profit in percentages, which was the result of production costs partly being accrued in euro. Restrictive cost management and a decrease in production costs, which resulted in more favorable purchase prices for iopamidol, the active ingredient in Iopamiron®, compensated for these negative currency effects.
After allocation of €101m of research and development costs and €13m of central production overhead/variances, segment result in 2003 was €88m, compared to €106m in 2002. This decline is mainly due to the reduced segment performance.
Latin America/Canada Region
The geographic segment referred to in this annual report as the Latin America/Canada Region comprises the countries of Latin America, the Caribbean, and Canada. Brazil, Mexico, and Canada were our three strongest sales markets in this Region in the period under review. We generated 62% of net sales for the segment in these countries in 2003.
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Latin America/Canada Region for the years ended December 31, 2003 and 2002:
Net sales for Latin America/Canada Region by business area: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Gynecology&Andrology | 254 | 292 | (13) | 66 | 68 |
Specialized Therapeutics | 73 | 73 | 0 | 19 | 17 |
Diagnostics&Radiopharmaceuticals | 29 | 33 | (12) | 8 | 8 |
Dermatology | 22 | 26 | (14) | 6 | 6 |
Other sources | 5 | 6 | (15) | 1 | 1 |
Total | 383 | 430 | (11) | 100 | 100 |
Net sales
Net sales in the Latin America/Canada Region declined by 11% to €383m in 2003. This development was mainly caused by the sharp drop in exchange rates against the euro in nearly all countries in the Region. However, currency adjusted net sales increased by 15%. This was due both to increased sales volumes (+5%) and to positive price effects (+10%). We recorded an increase in net sales in local currencies in the Region’s three largest markets: Brazil (+8%; total –16%), Mexico (+16%; total –13%), and Canada (+3%; total –3%). Net sales growth in local currencies was particularly strong in Argentina (+48%; total +22%), where the market is recovering from its economic crisis, and in Venezuela (+50%; total –12%).
Gynecology&Andrology was by far the strongest Business Area in this Region, generating net sales of €254m in 2003. We recorded a currency adjusted growth in net sales of 13% (total –13%) in this Business Area. The launch of Yasmin® was a particular success: by the end of 2003, this contraceptive was established in all major Latin American markets, with net sales up €16m. In the case of Diane®, our top-selling Gynecology&Andrology product in the Latin America/Canada Region, negative volume developments (–4%) were more than offset by price increases (+10%).
In the Specialized Therapeutics business area, net sales in local currencies rose by 18% (total 0%) in 2003. This was due to an increase in net sales of Betaferon®, which was the best-selling product in this Region in the year under review, with net sales of €45m (+19% currency adjusted; total +4%).
Net sales in the Diagnostics&Radiopharmaceuticals business area rose by 14% in local currencies (total –12%) compared to 2002. This positive development was due to volume growth of Iopamiron®.
Segment performance/Segment result
Segment performance declined by 4% to €137m in 2003. This reduction was therefore clearly lower than the percentage decline in the Region’s net sales, since currency effects positively affected overhead costs. Overall, the relation of marketing and selling costs to net sales decreased.
After allocation of €79m of research and development costs and €8m of central production overhead/variances, segment result in 2003 was €50m, compared to €43m in 2002. This increase was mainly due to the decline in research and development expenses.
Asia/Middle East Region
The geographic segment referred to in this annual report as the Asia/Middle East Region comprises the countries of Asia (with exception of Japan), and of the Middle and Far East, Egypt and Libya. In the period under review, South Korea, China, and Thailand were the three top-selling markets in the Region, accounting for 47% of segment sales.
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Asia/Middle East Region for the years ended December 31, 2003 and 2002:
Net sales for Asia/Middle East Region by business area: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Gynecology&Andrology | 85 | 93 | (8) | 43 | 42 |
Specialized Therapeutics | 32 | 30 | 10 | 16 | 13 |
Diagnostics&Radiopharmaceuticals | 69 | 77 | (11) | 35 | 35 |
Dermatology | 13 | 14 | (13) | 6 | 6 |
Other sources | 0 | 10 | n/a | 0 | 4 |
Total | 199 | 224 | (11) | 100 | 100 |
Net sales
Net sales in the Asia/Middle East Region declined by 11% to €199m in 2003. This decline was due to negative exchange rate effects (–10%) as well as negative price effects (–5%). Despite a decline in net sales of €10m in Indonesia, due to the termination of a sales partnership, sales volumes increased by 4%. We recorded an increase in net sales in local currencies in the Region’s three largest markets: South Korea (+6%; total –9%), China (+18%; total –1%), and Thailand (+12%; total –3%); the Middle East (+5%; total +5%) also developed well.
Net sales in local currency in the Gynecology&Andrology business area remained stable year-on-year (total –8%). The increase in net sales (currency adjusted as well as total) of Yasmin®, which was primarily generated in the Middle East, and Microgynon® compensated for the decline in other products, particularly in the hormone therapy business.
Net sales in the Specialized Therapeutics business area rose by €5m (+17% currency adjusted; total +10%). This increase is due in particular to volume growth of Betaferon® and Fludara®.
Net sales in the Diagnostics&Radiopharmaceuticals business area rose by 2% in 2003 after adjustment for exchange rate effects (total –11%). Volume increases (+7%) were mainly offset by adverse price developments (–5%). Net sales of Ultravist®, which accounted for approximately 73% of net sales by this Business Area in this Region, rose by 5% after adjustment for exchange rate effects (total –9%).
Segment performance/Segment result
In 2003, segment performance declined by 17% to €68m. Aside from the net sales decline of 11% due to currency effects, gross profit slightly decreased because production costs were partly accrued in euro. In addition, marketing and selling costs increased relative to net sales.
After allocation of €39m of research and development costs and €15m of central production overhead/variances, the segment result was €14m in 2003. The decline in segment result compared to 2002 is primarily caused by the reduced segment performance.
Other Activities
The Other Activities segment primarily consists of our pharmaceutical chemicals business with other pharmaceutical companies.
The following table sets forth the net sales by sub-segment, and net sales as a percentage of total net sales, for the Other Activities segment for the years ended December 31, 2003 and 2002:
Net sales of Other activities: | Year ended December 31, |
---|
| 2003 | 2002 | Percentage change from 2002 | 2003 | 2002 |
---|
| € | | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Pharmaceutical chemicals | 118 | 121 | (2) | 85 | 80 |
Other | 21 | 30 | (32) | 15 | 20 |
Total | 139 | 151 | (8) | 100 | 100 |
Net sales
Net sales of the Other Activities segment decreased by 8% in 2003 to €139m. Net sales of pharmaceutical chemicals declined slightly by 2% to €118m. This was primarily due to negative exchange rate effects (–4%), which were almost offset by volume increases (+3%) for a number of active substances and intermediates.
Net sales of the Other subsegment declined to €21m, down 32% from previous year’s figure. This was primarily due to lower net sales from sales partnerships and the discontinuation of toll manufacturing.
Segment performance/Segment result
Segment performance declined by 24% to €57m in 2003. This decline was primarily due to lower net sales from cooperation businesses. In addition, due to price and currency effects, gross profit of the pharmaceutical chemical business declined slightly despite lower production costs.
After allocation of €25m of research and development costs and €38m of central production overhead/variances, segment result in 2003 was €–6m as compared to €16m in 2002. This decrease primarily resulted from a lower segment performance.
2002 Compared to 2001
Group
Consolidated Income Statements | 2002 | 2001 |
---|
| € | % of net sales | € | % of net sales |
---|
| (in million, except percentages) |
---|
Net sales | 5,023 | 100 | 4,842 | 100 |
Cost of sales | (1,212) | 24 | (1,215) | 25 |
Gross profit | 3,811 | 76 | 3,627 | 75 |
Marketing and selling costs | (1,629) | 32 | (1,601) | 33 |
Engineering and administration costs | (566) | 11 | (525) | 11 |
Research and development costs | (947) | 19 | (864) | 18 |
Other operating income | 370 | | 348 | |
Other operating expenses | (298) | | (317) | |
Operating profit | 741 | 15 | 668 | 14 |
Financial result | (23) | | 30 | |
Income from disposal of Aventis CropScience | 689 | | | |
Acquisition-related expenses | (262) | | | |
Profit from ordinary activities | 1,145 | 23 | 698 | 14 |
Income taxes | (276) | 5 | (270) | 5 |
Net profit before minority interest | 869 | 17 | 428 | 9 |
Minority interest | (2) | | (10) | |
Net profit | 867 | 17 | 418 | 9 |
The following table sets forth our top-selling products during 2002. These products represented approximately 51% of the total net sales for the Group in 2002:
| Net sales | Percentage change from 2001 |
---|
| (€million) | |
---|
1. Betaferon® (Betaseron®) (therapeutics) | 783 | 15 |
2. Magnevist® (diagnostics) | 322 | 0 |
3. Iopamiron® (diagnostics) | 299 | (16) |
4. Ultravist® (diagnostics) | 241 | 1 |
5. Diane® (gynecology) | 226 | 5 |
6. Yasmin® (fertility control) | 152 | 236 |
7. Fludara® (therapeutics) | 149 | 14 |
8. Mirena® (fertility control) | 137 | 38 |
9. Microgynon® (Levlen®) (fertility control) | 130 | (6) |
10. Meliane® (fertility control) | 127 | 3 |
Total | 2,566 | |
Net sales
Net sales by the Schering AG Group increased by 4%, from €4,842m in 2001 to €5,023m in 2002. After adjustment for exchange rate effects, sales rose by 10%. The increase was due to increased sales volumes (+9%) as well as a slight rise in prices (+1%); these were offset by negative exchange rate developments (–6%). Net acquisitions/divestments at Group level of €21m had a positive effect of less than 1%.
Net sales by the Gynecology&Andrology business area rose 7% from €1,510m in 2001 to €1,613m in 2002. This was due in particular to continued high increases in sales of our oral contraceptive Yasmin®, which we introduced in 2001; net sales of this product amounted to €152m in 2002, as opposed to €45m in 2001. In addition, our Mirena® contraceptive generated an above-average increase in sales of 38%, to €137m. Sales of fertility control products rose by 12% (+20% currency adjusted); in contrast, sales by our hormone therapy business declined 9% (–1% currency adjusted).
Net sales in the Specialized Therapeutics business area rose by 10% to €1,637m in 2002, up from €1,491m in 2001. After adjustment for exchange rate effects, the sales increase amounted to 14%, of which 13% was due to organic growth and 1% to acquisitions/divestments. Acquisition/divestment effects are comprised of the purchase of Leukine®, a product which was acquired in July 2002 (+€33m), and the sale of non-core products (–€12m). The main drivers for the organic growth in the Specialized Therapeutics business area were the increase in net sales of Betaferon® (marketed in the U.S. and Canada under the trade name Betaseron®), Fludara®, Campath® (marketed in Europe under the trade name MabCampath™), Refludan® and Bonefos®. Net sales of Betaferon® rose 15% due to strong volume growt h (+20%) from €681m in 2001 to €783m in 2002. Positive price and volume effects in the case of Fludara® led to net sales for the product of €149m in 2002, up €131m (14%) compared to 2001. Our Campath® product, which we launched in 2001, generated increased net sales in 2002 of €46m (2001: €30m). Refludan®, for which we acquired the U.S. and European marketing rights in October 2001, generated net sales of €28m in 2002, €22m of which originated in the United States. Positive developments in the case of Bonefos® (+34%) are primarily the result of volume increases. Net sales of Betapace® in the U.S. declined from €95m in 2001 to €55m in 2002 (–41%), due to competition from generics.
In the Diagnostics&Radiopharmaceuticals business area, net sales were down 3% in 2002 to €1,406m (2001: €1,452m). At €334m, sales of MRI contrast agents were 2% higher in 2002 than in 2001 (€327m), despite adverse exchange rate effects (–6%); prices remained almost stable. This increase was mainly due to a slight rise in net sales of Magnevist®, from €320m in 2001 to €322m in 2002, as well as to a growth in net sales of our new product Gadovist® (from €6m in 2001 to €10m in 2002). Net sales of application technologies for contrast agents grew 9% in 2002 (+16% currency adjusted) to €264m, as opposed to €242m in 2001. In contrast, net sales of X-ray contrast media declined from €722m in 2001 to €654m in 2002 (–9%). This sharp decline in net sales is largely due to nega tive price and exchange rate effects (–4% and –6% respectively), especially in Japan; sales volumes remained essentially stable. We generated net sales of €146m with radiopharmaceuticals in 2002, 4% less than in the previous year.
Exchange rate effects meant that we recorded a decline in net sales in the Dermatology business area from €227m in 2001 to €217m in 2002 (–5%). However, net sales rose by 3% after adjustment for exchange rate effects. Our acne treatment Skinoren® recorded net sales growth of 17% for a total of €20m, despite adverse exchange rate effects (–6%).
Gross profit
Gross profit rose 5% from €3,627m to €3,811m in 2002. This increase slightly exceeded the growth in net sales of 4%.
Operating profit
At €741m, the operating profit was 11% up on the previous year’s figure. Marketing and selling costs rose less than net sales (+2%). Engineering and administration costs amounted to €566m, up 8% year-on-year. This increase is influenced by the costs of programs aimed at optimizing internal structures and processes at our production sites, such as the project to consolidate the formulation and packaging of liquid and solid dosage pharmaceuticals at our Berlin-Wedding site in Germany. Research and development expenses increased by 10% to €947m, up from €864m in 2001. They thus accounted for 19% of net sales. The improvement in net other operating income and expenses in the amount of €41m was mainly due to an improved result from foreign exchange-rate hedges.
Financial result
The decline in the financial result by €53m was largely due to lower income from our share in the result of Aventis CropScience, which has only been included for five months in 2002.
Income taxes
Income taxes rose from €270m to €276m. The decrease in the effective tax rate compared to 2001, from 39% to 24%, is primarily due to tax-free income from the disposal of Aventis CropScience. Income taxes in 2002 include one-time effects totaling €24m. These effects relate to the income from the disposal of Aventis CropScience and acquisition-related expenses as well as tax risks.
Net profit
Net profit rose from €418m in 2001 to €867m in 2002. Earnings per share (basic) amounted to €4.39, up from €2.11 in 2001. As described below, the increase in net profit and basic earnings per share is primarily due to the one-time effects in 2002 of the disposal of our 24% interest in Aventis CropScience, acquisition-related expenses of €262m and tax-related effects.
We believe that our net profit and basic earnings per share for 2002 were impacted by several significant non-recurring items, the effect of which may impair the ability of investors to make comparisons of such figures for 2002 with net profit and basic earnings per share for 2001. In order to improve the ability of investors to make a comparison of these figures for 2002 and 2001, set forth below is a table that includes (i) net profit and basic earnings per share for 2002 and 2001 as reported under IFRS, (ii) net profit and basic earnings per share for 2002 after being adjusted for these non-recurring items, and (iii) a reconciliation of net profit and basic earnings per share from an as reported under IFRS basis to an adjusted basis for 2002.
| 2002 | 2001 | Percentage change |
---|
| (€million; per share amounts in €) |
---|
Net profit (IFRS) | 867 | 418 | 107 |
Income from disposal of Aventis CropScience | (689) | – | – |
Acquisition-related expenses | 262 | – | – |
One-time tax effects | 24 | – | – |
Net profit on a comparable basis | 464 | 418 | 11 |
Basic earnings per share (IFRS) | 4.39 | 2.11 | 108 |
Basic earnings per share on a comparable basis | 2.35 | 2.11 | 11 |
The €689m of income from the disposal of our 24% interest in Aventis CropScience relates to the €1,500m of proceeds less the carrying amount of €526m and indemnities of €285m.
The acquisition-related expenses of €262m in 2002 related to €224m for the acquisition of the rights to the Phase II-development project for the use of Leukine® in Crohn's disease, to €20m for the formation of the Schering Stiftung (a foundation under German law) for the promotion of science and culture, and to €18m for adjustments of the carrying amounts of assets and liabilities in connection with the acquisition of the 60% interest in CIS bio international in 2000. One-time tax effects of €24m in 2002 related to the income from the disposal of Aventis CropScience and the acquisition-related expenses as well as tax risks.
Results of Operations by Segment
Net sales, segment performance and segment result of each of our geographic segments and our Other Activities segment are presented in Note 33 to our Consolidated Financial Statements and in accordance with IAS 14 (revised).
Europe Region
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Europe Region for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| 2002 | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales for Europe Region by business area: | | | | |
Gynecology&Andrology | 921 | 39 | 845 | 39 |
Specialized Therapeutics | 843 | 36 | 749 | 34 |
Diagnostics&Radiopharmaceuticals | 450 | 19 | 442 | 20 |
Dermatology | 132 | 6 | 135 | 6 |
Other sources | 11 | 0 | 12 | 1 |
Total | 2,357 | 100 | 2,183 | 100 |
Net sales
Net sales in the Europe Region increased from €2,183m in 2001 to €2,357m in 2002, a rise of 8%. This was due to positive price and volume effects (+10%), although these were partially offset by the divestment of the general practitioners’ range of AWAG Arzneimittelwerke Altona AG (formerly Asche AG) in Germany (–1%) and negative exchange rate developments (–1%) in nearly all countries not belonging to the European Monetary Union. Net sales were affected by government-imposed price cuts, budget restrictions, positive and negative lists for the reimbursement of products, and the increased use of generic substitute products.
In Germany, net sales rose 7% (+10% after adjustment for the divestment of AWAG), from €532m in 2001 to €571m in 2002. This increase was mainly attributable to Yasmin® (+€5m), Diane® (+€6m) and Valette® (+€6m), as well as to a 24% growth in net sales of Betaferon® from €88m in 2001 to €109m in 2002. In contrast, net sales of Ultravist® declined 10% to €35m in 2002 (2001: €38m), mainly as a result of substantial negative price effects (–8%).
In France, net sales climbed 7% to €306m in 2002, as opposed to €286m in 2001. This was mainly the result of increased sales volumes, coupled with the introduction of two new products in 2002: Yasmin® (+€5m) and MabCampath® (+€2m). Net sales of Bonefos® rose from €1m in 2001 to €7m in 2002, while net sales of Mirena® grew 15% from €20m in 2001 to €23m in 2002.
Net sales in Great Britain increased 4% from €146m in 2001 to €152m in 2002. This rise is mainly due to volume increases (+6%), which were partially offset by a negative exchange rate effect (–2%). Two new product launches contributed to this increase: Yasmin®, which generated €3m in net sales, and MabCampath™, where sales rose from €1m to €3m.
In Italy, net sales climbed 8% to €268m in 2002, up from €249m in 2001. This development was primarily the result of increases in net sales of Mirelle® (up from €7m to €12m) and of Betaferon® (up 13% from €27m to €30m). Overall, volume increases were the main reason for the rise.
Spain recorded an increase in net sales in 2002 of 6% to €188m, in comparison to the figure for 2001 of €178m. Price and volume developments (+8%) were partially offset by negative exchange rate effects (–2%) experienced by the non-European subsidiaries of the Justesa Imagen Group. Key sales drivers were volume increases for Betaferon®, Ilomedin®, Meliane® and Mirelle®.
In Finland, net sales – which include global exports by Leiras – rose slightly from €117m in 2001 to €118m in 2002. The sale of our majority interest in the joint venture Oy Leiras Finland AB to Nycomed Pharma AS effective December 31, 2002, did not impact net sales in 2002. However, net sales in Finland are likely to fall in 2003.
The strongest net sales growth in the year under review was recorded by the Central and Eastern European markets. Net sales in this area rose by 23% to €185m in 2002, from €150m the previous year; by 22% after adjustment for exchange rate effects. The increase was primarily attributable to higher sales volumes of Betaferon®, Diane® and Meliane®.
Our Gynecology&Andrology business area achieved net sales growth of 9% (+10% currency adjusted) due to volume increases and price adjustments, rising to €921m in 2002 from €845m in 2001. Net sales of Mirena®, Meliane®, Mirelle® and Yasmin® all rose significantly in 2002. Net sales of Yasmin® climbed to €54m in 2002, compared with €28m the previous year. Mirena® recorded a 14% increase from €80m in 2001 to €92m in 2002, with substantial increases in net sales being seen in France, Great Britain and the Central European markets in particular. Net sales of Meliane® increased by 15%, rising from €79m in 2001 to €90m in the year under review, while net sales of Mirelle® rose from €18m in 2001 to €29m in 2002.
Net sales in the Specialized Therapeutics business area increased by 12% (or 13% currency adjusted) from €749m in 2001 to €843m in 2002. Key drivers of this growth were significant increases in sales volumes of Betaferon®, Bonefos® and MabCampath™. Net sales of Betaferon® rose 14% from €326m in 2001 to €372m in 2002, while those of Bonefos® climbed 35% to €46m in 2002 (2001: €34m). Net sales of MabCampath™ increased from €2m in 2001 to €13m in 2002.
We achieved 2% net sales growth in the Diagnostics&Radiopharmaceuticals business area, from €442m in 2001 to €450m in 2002. Net sales of radiopharmaceuticals amounted to €103m in 2002 compared to €105m in 2001. Positive increases in sales volumes of Ultravist® more than offset price cuts and negative exchange rate effects, with the result that net sales rose slightly from €145m in 2001 to €148m in 2002. In addition, net sales of Magnevist® rose from €84m in 2001 to €92m in 2002 due to price and volume increases, despite negative exchange rate effects.
Net sales in the Dermatology business area declined slightly (2%) to €132m in 2002, compared to €135m in 2001. Positive price and volume effects were more than offset by negative exchange rate effects. After adjustment for currency effects, growth amounted to 2%. Our leading product in this area was Advantan®, net sales of which increased by 5% in 2002 to €29m (+10% currency adjusted). In contrast, net sales of Psorcutan® and Travocort® declined slightly due to adverse exchange rate effects.
Segment performance/Segment result
Segment performance improved by 13% to €1,040m in 2002, compared with €922m in 2001, and thus grew faster in percentage terms than net sales. This was due to a higher percentage gross profit resulting from a higher-margin product mix, as well as to the fact that overheads grew less than net sales.
After allocation of €430m of research and development costs and €62m of central production overhead/variances, the segment result in 2002 was €548m, representing an increase of 19% from €460m in 2001. This increase was primarily driven by the improved segment performance as well as by stable central production overhead/variances in 2002 compared to 2001.
United States Region
The following table sets forth the net sales by sub-segment, and net sales by sub-segment expressed as a percentage of total net sales, of the United States Region for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| 2002 | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales for United States Region by sub-segment: | | | | |
Berlex | 1,019 | 79 | 875 | 79 |
Medrad | 263 | 21 | 238 | 21 |
Total | 1,282 | 100 | 1,113 | 100 |
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the United States Region, for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| 2002 | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales for United States Region by business area: | | | | |
Gynecology&Andrology | 252 | 19 | 187 | 17 |
Specialized Therapeutics | 561 | 44 | 485 | 44 |
Diagnostics&Radiopharmaceuticals | 460 | 36 | 437 | 39 |
Dermatology | 9 | 1 | 4 | — |
Total | 1,282 | 100 | 1,113 | 100 |
Net sales
Net sales in the United States Region increased by 15%, rising from €1,113m in 2001 to €1,282m in 2002. This growth was generated by a sharp volume increase (+22%), whereas prices remained almost constant and exchange rate effects were negative (–7%). The increase in sales volumes can be broken down into organic growth of 19% and an acquisition effect of 3%.
Berlex recorded net sales of €1,019m in 2002, as opposed to €875m in 2001; this corresponds to a growth rate of 16%. Medrad’s net sales increased by 11% from €238m in 2001 to €263m in 2002. After adjustment for currency effects, the increase in net sales amounted to 18%. This growth was due to increased sales volumes for vascular injectors (+19%), MR injection systems (+26%), angiography injection systems (+24%) and syringes (+19%).
Net sales by the Specialized Therapeutics business area, which accounted for approximately 55% of Berlex’ total net sales, rose by 16% from €485m in 2001 to €561m in 2002; after adjustment for currency effects, the growth rate was 23%. This growth in net sales is primarily due to increased net sales of Betaseron®, Fludara® and Refludan®. Leukine®, which was acquired in July 2002, contributed €33m to the increase in net sales. Betaseron® recorded net sales growth of 18% in 2002 to €336m, as opposed to €285m in 2001. Fludara® net sales rose 17% to €82m in 2002 (2001: €70m). Refludan®, a cardiovascular product that we acquired in November 2001, contributed €22m of net sales in 2002 (previous year: €3m). In contrast, net sales of Betapace®, market exclusivity for w hich in the United States expired in April 2000, continued to decline, falling from €95m in 2001 to €55m in 2002.
In the Diagnostics&Radiopharmaceuticals business area, net sales increased by 5% from €437m in 2001 to €460m in 2002. After adjustment for the net sales attributable to Medrad, a slight decrease of 1% was recorded, with net sales falling from €199m in 2001 to €197m in 2002. Net sales of Magnevist® and Ultravist® were the primary reason for this development. Net sales of Magnevist® only increased by 2% (+8% currency adjusted) from €142m in 2001 to €145m in 2002, whereas Ultravist® recorded a decrease of 14% (–8% currency adjusted) from €20m in 2001 to €18m in 2002.
The Gynecology&Andrology business area generated a distinct increase in net sales from €187m in 2001 to €252m in 2002; this corresponds to net sales growth of 35% (+43% currency adjusted). The drivers for this growth were the new products that were successfully launched in 2001: Yasmin® and Mirena®. Yasmin® generated net sales of €95m in 2002 (2001: €17m), while Mirena® contributed €36m in 2002 compared to €13m in 2001. With regard to our hormone therapy activities, by contrast, price adjustments for Climara® could not offset the negative exchange rate effect and lower sales volumes. As a result, net sales decreased from €85m in 2001 to €71m in 2002.
Net sales for our Dermatology business area in the United States Region, which was established in 2000, grew from €4m in 2001 to €9m in 2002. This increase was attributable to our acne treatment product Finevin®, sales of which climbed to €8m in 2002 from €3m in 2001.
Segment performance/Segment result
Segment performance improved by 16% to €366m in 2002, compared with €315m in 2001, and thus grew slightly faster in percentage terms than net sales. This was due in particular to the higher percentage gross profit that resulted from new products with higher gross margins, such as Yasmin®, as well as to the decrease in the costs of marketing and selling compared with net sales. These positive effects were partially offset by the write-off on the development and commercialization rights for Levulan®.
After allocation of €251m of research and development costs and €11m of central production overhead/variances, segment result in 2002 increased to €104m in 2002, compared to €72m in 2001. This sharp increase was mainly driven by a better segment performance. Due to our strategic commitment to significantly expand our business in the United States, research and development expense as a percentage of net sales, was above the average percentage in the Schering AG Group.
Japan Region
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Japan Region for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| 2002 | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales for Japan Region by business area: | | | | |
Gynecology&Andrology | 30 | 5 | 29 | 4 |
Specialized Therapeutics | 129 | 22 | 145 | 22 |
Diagnostics&Radiopharmaceuticals | 386 | 67 | 451 | 68 |
Dermatology | 34 | 6 | 38 | 6 |
Total | 579 | 100 | 663 | 100 |
Net sales
Net sales in the Japan Region declined by 13% from €663m in 2001 to €579m in 2002. This development was primarily caused by the weakness of the yen against the euro and the government-imposed price reductions. With sales volumes remaining virtually the same, the decline in net sales resulted from negative exchange rate developments (–7%) and negative price effects (–6%).
In the Diagnostics&Radiopharmaceuticals business area, which accounted for 67% of net sales in this Region in the year under review, net sales decreased by 14% from €451m in 2001 to €386m in 2002. The primary reason for this decline was a decrease in net sales, due to exchange rate effects and price cuts of the X-ray contrast media Iopamiron® and Ultravist®, and of the MRI contrast agent Magnevist®. Radiopharmaceuticals contributed €9m in net sales in 2002.
The Gynecology&Andrology business area recorded a 2% increase (+11% currency adjusted) to €30m in 2002, up from €29m in 2001. Negative exchange rate effects were more than offset by volume increases. The same effects were also seen in relation to Triquilar®, net sales of which rose from €5m in 2001 to €6m in 2002.
Despite slight volume growth, net sales for the Specialized Therapeutics business area declined, due to a sharp decrease in exchange rates and negative price effects. Net sales in the year under review were down 11% (–3% currency adjusted) to €129m (2001: €145m). The increase in net sales of Betaferon® from €15m in 2001 to €23m in 2002 could not offset the decline in net sales of most of the other products.
In the Dermatology business area, net sales decreased by 11%, from €38m in 2001 to €34m in 2002. This is primarily due to negative exchange rate and price effects, coupled with flat sales volumes for the top-selling products in this Business Area, Neriproct® and Nerisona®.
Segment performance/Segment result
Segment performance declined by 6% from €244m in 2001 to €229m in 2002, thus falling significantly less in percentage terms than net sales. This was largely due to the fact that the costs of marketing and selling declined faster than net sales, as well as to positive effects relating to production costs. The decrease in production costs resulted primarily from more favorable purchase prices for iopamidol, the active ingredient in Iopamiron®, our best-selling product in Japan.
After allocation of €109m of research and development costs and €14m of central production overhead/variances, segment result in 2002 was €106m, representing a nearly unchanged segment result compared to €107m in 2001.
Latin America/Canada Region
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Latin America/Canada Region for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| 2002 | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales for Latin America/Canada Region by business area: | | | | |
Gynecology&Andrology | 292 | 68 | 340 | 67 |
Specialized Therapeutics | 73 | 17 | 84 | 16 |
Diagnostics&Radiopharmaceuticals | 33 | 8 | 45 | 9 |
Dermatology | 26 | 6 | 33 | 6 |
Other sources | 6 | 1 | 9 | 2 |
Total | 430 | 100 | 511 | 100 |
Net sales
Net sales in the Latin America/Canada Region declined by 16% from €511m in 2001 to €430m in 2002. This development was heavily influenced by the substantial fall in exchange rates against the euro in nearly all countries in this Region. After adjustment for currency effects, net sales actually rose by 12% due to price effects.
In Argentina, net sales plummeted by 62% as a result of the sharp fall in the Argentinean peso and the ongoing economic crisis for a total of €28m in 2002 (2001: €75m). This decrease was due to a fall in sales volumes (–18%) and extremely negative exchange rate effects (–80%), which were only partially offset by positive price effects (+36%). Net sales in Brazil decreased by 10% from €137m in 2001 to €124m in 2002; positive price and volume developments (+17%) were unable to compensate for the highly negative development in exchange rates (–27%). In Venezuela (–29%) and Mexico (–12%), net sales also declined as a result of negative exchange rate and volume effects. In Colombia, net sales climbed from €37m in 2001 to €38m in 2002 (+4%). Canada recorded slight growth in net sales (+3%), rising fro m €66m in 2001 to €68m in 2002.
The Gynecology&Andrology business area recorded a 14% decline in net sales from €340m in 2001 to €292m in 2002. Mirena® (+€2m), Mirelle® (+€2m) and Miranova® (+€1m) performed particularly well in view of the difficult economic situation in the Region. Diane® almost offset negative exchange rate effects (–24%) with encouraging volume growth (+15%) and price developments (+8%). In contrast, net sales of Microgynon®, Meliane® and Triquilar® declined by 19%, 18% and 27% respectively, mainly as a result of exchange rate effects.
Net sales in the Specialized Therapeutics business area declined by 14% from €84m in 2001 to €73m in 2002. Net sales of Betaferon® decreased from €47m in 2001 to €43m in 2002, since negative exchange rate effects (–22%) were only partially offset by volume and price increases (+15%). Net sales of Androcur® decreased substantially due to competitive pressure from generics, from €17m in 2001 to €11m in 2002. In contrast, net sales of Fludara® rose 4% from €8m in 2001 to €9m in the year under review.
In the Diagnostics&Radiopharmaceuticals business area, net sales declined substantially (26%) from €45m in 2001 to €33m in 2002. The main reason for this negative development was the decline in net sales of Iopamiron®, which fell 33% from €26m in 2001 to €17m in 2002. This is mainly due to lower sales volumes in Mexico and negative exchange rate effects in Argentina and Brazil.
Net sales in the Dermatology business area fell 21% from €33m in 2001 to €26m in 2002. This change was mainly due to a decline in net sales of Nerisona® (–€2m) and Travogen® (–€2m).
Segment performance/Segment result
Segment performance declined by 16% from €170m in 2001 to €143m in 2002. The decrease in segment performance thus corresponds to the percentage decline in this Region’s net sales. The slight increase in production costs compared with net sales was offset by the slight decrease in the costs of selling compared with net sales.
After allocation of €93m of research and development costs and €7m of central production overhead/variances, segment result in 2002 was €43m, compared to €95m in 2001. This decline is mainly due to a reduced segment performance as well as an increase in research and development expenses. Due to negative currency effects primarily in Argentina and Brazil, net sales decreased, whereas research and development expenses allocated to the segment have not been impacted by the weakening Latin American currencies. As a consequence, research and development expense, as a percentage of net sales, is slightly above the average percentage in the Schering AG Group.
Asia/Middle East Region
The following table sets forth the net sales by business area, and net sales by business area expressed as a percentage of total net sales, of the Asia/Middle East Region for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| 2002 | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales for Asia/Middle East Region by business area: | | | | |
Gynecology&Andrology | 93 | 42 | 81 | 38 |
Specialized Therapeutics | 30 | 13 | 27 | 13 |
Diagnostics&Radiopharmaceuticals | 77 | 35 | 77 | 36 |
Dermatology | 14 | 6 | 15 | 7 |
Other sources | 10 | 4 | 13 | 6 |
Total | 224 | 100 | 213 | 100 |
Net sales
Net sales in the Asia/Middle East Region increased by 5% from €213m in 2001 to €224m in 2002. This positive development was the result of increased sales volumes (+11%), which were partially offset by negative price developments (–4%) and exchange rate effects (–2%). In South Korea, net sales rose 15% in 2002 despite adverse exchange rate effects, from €54m in 2001 to €62m. Thailand also recorded a strong increase in net sales (11%), from €15m in 2001 to €17m in 2002. In Indonesia, by contrast, higher sales volumes and stable exchange rates only partially offset negative price developments. As a result, net sales decreased 6%, from €20m in 2001 to €18m in 2002.
In the Gynecology&Andrology business area, net sales rose by 15% from €81m in 2001 to €93m in 2002. Factors contributing to this increase included our new products Yasmin® (+€2m) and Mirena® (+€2m). The net sales increases recorded for Diane® (up 23% to €17m) and Femovan® (up 13% to €13m) were primarily due to increases in sales volumes, which were partially offset by slightly negative exchange rate developments.
Net sales in the Specialized Therapeutics business area rose by 8% from €27m in 2001 to €30m in 2002. This increase is due in particular to positive volume developments for Betaferon® and Bonefos®. Net sales of Betaferon® rose €7m in 2001 to €9m in 2002. In the case of Bonefos®, net sales increased from €5m in 2001 to €6m in 2002.
In the Diagnostics&Radiopharmaceuticals business area, net sales amounted to €77m in 2002, in line with last year’s level. Volume increases (+8%) were compensated by adverse price developments (–5%) and exchange rate effects (–3%). Net sales of Ultravist®, which accounted for approximately 72% of diagnostics sold in this Region in 2002, rose from €53m in 2001 to €55m in 2002. Net sales of Magnevist® in 2002 amounted to €14m, as in the previous year, since adverse price and exchange rate developments offset higher sales volumes.
In the Dermatology business area, net sales declined in 2002 compared to 2001 by 3%, from €15m to €14m. Positive price effects only partially compensated for a slight decline in sales volumes and negative exchange rate effects. Increased net sales of Skinoren® and Advantan® were unable to offset the overall negative development in this Business Area.
Segment performance/Segment result
Segment performance increased by 14% from €72m in 2001 to €82m in 2002. This was due to net sales growth of 5%, as well as to the fact that both the costs of selling and production rose less than net sales.
After allocation of €40m of research and development costs and €13m of central production overhead/variances, segment result was €29m in 2002. The decline in segment result compared to 2001 is mainly caused by an increase in research and development expense. The research and development expense reflects the segment’s anticipated growth potential and is as a percentage of net sales in line with the average percentage in the Schering AG Group.
Other Activities
The following table sets forth the net sales by sub-segment, and net sales as a percentage of total net sales, for the Other Activities segment for the years ended December 31, 2002 and 2001:
| Year ended December 31, |
---|
| | 2002 | | 2001 |
---|
| € | Percentage of net sales | € | Percentage of net sales |
---|
| (in million, except percentages) |
---|
Net sales of Other activities: | | | | |
Pharmaceutical chemicals | 121 | 80 | 118 | 74 |
Other | 30 | 20 | 41 | 26 |
Total | 151 | 100 | 159 | 100 |
Net sales
Net sales by the Other Activities segment declined by 4% in 2002 compared to the previous year, from €159m to €151m. Net sales of pharmaceutical chemicals increased by 3% to €121m in 2002 from €118m in 2001. This was primarily due to volume increases for a number of active ingredients and intermediates, which offset negative exchange rate effects.
At €30m, net sales by the Other subsegment were 26% down on the previous year’s figure of €41m. This was primarily due to lower net sales from sales partnerships and the discontinuation of toll manufacturing by Other Activities. We are now using this capacity ourselves as part of our Global Production Strategy.
Segment performance/Segment result
Segment performance declined by 6% from €80m in 2001 to €75m in 2002. This decrease was primarily due to lower net sales, as well as to higher administration costs compared with net sales.
After allocation of €24m of research and development costs and €35m of central production overhead/variances, segment result in 2002 was €16m compared to €33m in 2001. This decrease primarily resulted from a slightly lower segment performance as well as from an increase in research and development expenses, which are still below group average as a percentage of net sales.
Changes in Accounting Policies
IFRS
We have applied IFRS since 1994. The IASB has issued a number of new standards as part of its project to develop a core set of International Financial Reporting Standards. Accordingly, we have adopted or will adopt a number of new or revised International Financial Reporting Standards as described below. Our policy is to adopt all new standards at the required adoption date.
As of January 1, 2001, we adopted IAS 39 "Financial Instruments: Recognition and Measurement". Accordingly, fair values are usually used in accounting for financial instruments. The adoption of IAS 39 had no impact on net profit. The effects on reporting are described in Note 4 to our Consolidated Financial Statements.
As of January 1, 2001, we adopted IAS 40 "Investment Property". IAS 40 introduces a fair value accounting model for investment property held to earn rentals or for capital appreciation or both. The adoption of this standard as of January 1, 2001, did not change our previous valuation and accounting policies, as we opted for the cost model.
U.S. GAAP
SFAS No. 133 “Accounting for Derivative Instruments and Hedging Activities” is effective for fiscal periods beginning after June 15, 2000. The statement requires all derivatives to be recognized in the balance sheet as either assets or liabilities and measured at fair value. In addition, all hedging relationships must be designated, documented and reassessed pursuant to the provisions in the standard. As of January 1, 2001, our hedging of anticipated revenues and expenses is accounted for as cash flow hedge under U.S. GAAP.
We have applied SFAS No. 141 “Business Combinations” and SFAS No. 142 “Goodwill and Other Intangible Assets” since January 1, 2002. SFAS No. 141 requires the use of the purchase method of accounting for all business combinations. In addition, it establishes criteria for the separate recognition of intangible assets from goodwill. The estimated remaining useful lives of existing intangible assets were reviewed effective January 1, 2002 and, where necessary, their amortization periods adjusted to reflect the changes in their remaining useful lives. Under SFAS No. 142, goodwill and intangibles with indefinite lives are no longer subject to amortization, but must be tested for impairment annually using a defined procedure, resulting in the recognition of an impairment loss if appropriate.
Critical Accounting Policies
The preparation of our Consolidated Financial Statements in conformity with IFRS requires management to make estimates and assumptions. This is affecting the reported amounts of assets, liabilities, revenues and expenses, as well as disclosure of contingent assets and liabilities. Some of those judgements can be subjective in nature and complex, and consequently actual results could differ from those estimates. For any given individual estimate or assumption made by the company, there may also be other estimates or assumptions that the company reasonably could have used. If the accounting estimate required to make assumptions about matters that were highly uncertain at the time the accounting estimate was made and if different estimates that reasonably could have been used would have a material impact on the presentation of the financial condition, changes in financial condition or results of operations, the accounting estimate would constitute a critical accounting policy. The following critical accounting policies should be considered in reviewing our Consolidated Financial Statements.
In addition to our Consolidated Financial Statements in accordance to IFRS we provide a reconciliation to U.S. GAAP in Note 37 to our Consolidated Financial Statements which differs in certain respects from IFRS.
The Group does not consider any specific accounting policy to be critical to the economic success of the Group.
Critical accounting policies under IFRS
Our critical accounting policies include provisions, accounting for expected third-party claims, the impairment of long lived assets, the accounting for pension plans and the recoverability of deferred tax assets.
Provisions
We recognize provisions for current and deferred taxes, personnel costs as well as environmental warranty and litigation risks when we have a present obligation as a result of a past event and it is probable that an outflow of resources embodying economic benefits will be required to settle the obligation and a reliable estimate can be made of the amount of the obligation. Long-term provisions are reported at their discounted value. The determination of probabilities is based on past experience and the circumstances known at the time of decision, but also requires subjective management judgement. As a consequence, the actual liability might be significantly higher.
Accounting for expected third-party claims
Provisions for third-party claims include mainly indemnities relating to the sale of business activities.
During fiscal year 2002, we completed the sale of our 24% ownership interest in Aventis CropScience to Bayer AG. The purchase agreement contained a range of indemnities and representations and warranties, relating mainly to financial statement guarantees, environmental matters, tax liabilities, the funding of employee benefit plans, social contributions and product liabilities. The possible indemnities, representations and warranties are uncertain in nature. Therefore, the estimation of the amount of expected claims requires subjective assumptions and management judgement. The actual outcome regarding the filing of claims as well as the actual amount attributable to a filed claim might differ significantly from management’s expectations.
Impairment of long-lived assets
We review our long-lived assets for impairment, including identifiable intangibles and goodwill, whenever events or changes in circumstances indicate (triggering event) that the carrying amount of the asset may not be recoverable. In order to assess if assets are impaired, we estimate the recoverable amount of the asset by the higher of either the present value of future cash flows expected to result from the use of the asset (value in use) or its net selling price. If the recoverable amount is less than the carrying amount of the asset, we will recognize an impairment loss for the amount by which the asset’s carrying amount exceeds its recoverable amount. For purposes of determining the value in use, we group our assets at the lowest level for which separately identifiable cash flows are available. For estimating future cash flows, we use our internal budgets. Thereby, considerable management judgement is necessary to identify a triggering event and to estimate future sales and cost of sales which underlie the present value of future cash flows. Accordingly, actual outcomes could vary significantly from such estimates. Factors such as changes in the planned use of assets or closing of facilities or lower than anticipated sales for products could result in shortened useful lives or impairments.
Pension plans
We account for pensions in accordance with actuarial valuations, which rely on statistical and other factors in order to anticipate future events (see Note 4 to our Consolidated Financial Statements). These factors include key actuarial assumptions about the discount rate and rate of future compensation increases. In addition, our actuarial consultants also make use of subjective assumptions such as fluctuations and mortality rates. These actuarial assumptions may differ materially from actual developments due to changing market and economic conditions, changes in fluctuation rates or changes in live expectancy of participants, thereby resulting in a significant increase of the projected benefit obligation (PBO).
Also, the calculation of pension expenses is partly based on an expected long-term rate of return on plan assets and the market related value of plan assets. The expected rate-of-return of 7% is based on historical and expected future averages for risk premiums and absolute returns of the considered asset categories. They are also cross-checked with market expectations of external sources. We consider the resulting return assumptions as realistic within the long-term investment horizon of the pension trust. The market-related value of plan assets for the Schering Pension Trust is based upon the fair value of plan assets at the measurement date. Actual return on plan assets may differ significantly from the expected amounts.
The estimated effect of net unrealized losses on future pension expenses amounts to €5m per year (2003: €10m).
Deferred tax assets
We apply the liability method to accounting for income taxes. Deferred tax assets are recognized for the expected future tax consequences of temporary differences between the carrying amount of assets and liabilities in the balance sheet and their associated tax bases. Deferred tax assets are measured at the tax rates which are expected to be in effect for the years in which the differences are expected to reverse, based on tax rates and laws that have been enacted or substantively enacted by the balance sheet date. Thereby, the recognition of a deferred tax asset requires significant management judgement on the probability of the deferred tax asset to be recovered against future taxable profits.
Critical Accounting Policies under U.S. GAAP deviating from IFRS
Goodwill
According to IAS 38, goodwill should be amortized on a systematic basis over its useful life. Since January 1, 2002, goodwill arising from acquisitions is not amortized under U.S. GAAP. Instead, SFAS No. 142 requires that goodwill be tested for impairment at least annually using a two-step approach at the reporting unit level. The reporting units are our primary segments, which are geographical. In the first step, the fair value of the reporting unit is compared to its book value (carrying amount) including goodwill. In order to determine the fair value of the reporting unit, significant management judgement is applied in order to estimate the underlying discounted future free cash flows. In the case, that the fair value of the reporting unit is less than its book value, a second step needs to be performed which compares the fair value of the report ing unit’s goodwill to the book value of its goodwill. The fair value of goodwill is determined based upon the difference between the fair value of the reporting unit and the net of the fair values of the identifiable assets and liabilities of the reporting unit. If the fair value of goodwill is less than the book value, the difference is recorded as an impairment. Impairment testing, which was performed on the basis of the present value of estimated future cash flows, did not result in an impairment of goodwill in 2002.
The most recent fair value determination in 2002, which was based on the present value of estimated future cash flows, resulted in an amount that exceeded the carrying amount of the corresponding reporting unit by a substantial margin. The assets and liabilities that make up the reporting unit have not changed significantly since the most recent fair value determination in 2002. Based on an analysis of events that have occurred and circumstances that have changed since the most recent fair value determination in 2002, the likelihood that a current fair value determination would be less than the current carrying amount of the reporting unit is remote. Accordingly, no goodwill was written down for impairment in 2003.
The future actual cash flows may differ significantly from estimated cash flows, thereby requiring an impairment in later periods.
New Accounting Standards
U.S. GAAP
In July 2002, the Financial Accounting Standards Board issued SFAS No. 146 “Accounting for Costs Associated with Exit or Disposal Activities” which nullifies Emerging Issues Task Force (EITF) Issue 94-3 “Liability Recognition for Certain Employee Termination Benefits and Other Costs to Exit an Activity (including Certain Costs Incurred in a Restructuring)”. SFAS No. 146 requires that a liability associated with exit or disposal of activities be recognized only when the liability is incurred, and not when the entity concerned commits to an exit or disposal plan. SFAS No. 146 is effective for all exit or disposal activities initiated after December 31, 2002. The application of this standard had no material impact on our U.S. GAAP reconciliation.
On April 30, 2003, the Financial Accounting Standards Board issued SFAS No.149 “Amendment of Statement 133 on Derivative Instruments and Hedging Activities”. This standard amends and clarifies financial accounting and reporting for derivative instruments, including certain derivative instruments and derivative instruments embedded in other contracts and for hedging activities. SFAS No. 149 is effective for contracts entered into or modified after June 30, 2003. The application of this standard had no material impact on our U.S. GAAP reconciliation.
On May 15, 2003, the Financial Accounting Standards Board issued SFAS No. 150 “Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity”. Under SFAS No. 150, certain financial instruments, previously classified as equity are now required to be classified as liability by the issuer. SFAS No. 150 primarily affects accounting for financial instruments that embody an obligation to repurchase equity instruments that have been issued by the company. SFAS No. 150 is effective for transactions entered into or modified after May 31, 2003. The application of this standard had no impact on our U.S. GAAP reconciliation.
In December 2003, the Financial Accounting Standards Board issued SFAS No. 132 (revised 2003) “Employers’ Disclosures about Pensions and Other Postretirement Benefits”. SFAS No. 132 (revised 2003) is effective for fiscal years ending after December 15, 2003. The standard requires companies to provide more detailed disclosures about pensions and other postretirement benefit plans. Among other things, companies are required to describe investment policies and strategies and to provide a description of the basis used to determine the overall expected long-term rate-of-return-on-assets together with a classification of the plan assets by investment classes. The disclosures required are reported in Note (24).
Under SFAS No. 140 “Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities”, qualifying special purpose entities are exempted from consolidation under certain circumstances. In January 2003, the FASB published FIN No. 46 “Consolidation of Variable Interest Entities –an interpretation of ARB No. 51”, which clarifies the application of the consolidation rules to certain variable interest entities which do not qualify as qualifying special purpose entities. FIN No. 46 applies immediately for variable interest entities created after January 31, 2003. By issuing FASB Staff Position (FSP) FIN 46-6 “Effective Date of FASB`s Interpretation No. 46, Consolidation of Variable Interest Entities”, the Financial Accounting Standards Board deferred the effective date for initial application of FIN No. 46 for VIE`s created before February 1, 2003 to December 31, 2003. In December 2003, the FASB issued FIN 46 (revised December 2003). According to FIN 46 (revised December 2003), the provisions of FIN 46 or FIN 46 (revised December 2003) shall be applied to all variable interest entities no later then the end of the first reporting period that ends after March 31, 2004. Our U.S. GAAP reconciliation is not affected by the FASB rules, since we hold no investment that is classified as a qualifying special purpose entity or a variable interest entity.
United States GAAP Reconciliation
As discussed elsewhere in this annual report, we prepared our Consolidated Financial Statements in accordance with IFRS. IFRS differ in certain material respects from United States Generally Accepted Accounting Principles. A comparison of net profit, earnings per share (basic) and shareholders' equity at, or for the year ended, December 31, 2003, 2002 and 2001 determined under IFRS and after reflecting the material adjustments which would arise if United States Generally Accepted Accounting Principles were to be applied instead of IFRS is shown below.
| December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| $ | € | € | € |
---|
| (in millions, except per share data) |
---|
Net profit: | | | | |
IFRS | 558 | 443 | 867 | 418 |
United States GAAP | 616 | 489 | 848 | 403 |
Earnings per share (basic): | | | | |
IFRS | 2.87 | 2.28 | 4.39 | 2.11 |
United States GAAP | 3.17 | 2.52 | 4.30 | 2.04 |
Shareholders' equity: | | | | |
IFRS | 3,656 | 2,902 | 2,934 | 2,556 |
United States GAAP | 3,561 | 2,827 | 2,794 | 2,457 |
As more fully described and quantified in Note 37 to our Consolidated Financial Statements, the major differences between IFRS and United States Generally Accepted Accounting Principles relate to accounting for business combinations (research-in-process charges; amortization of goodwill), compensation costs for early retirement programs, provisions for pensions and stock option plans, capitalization of interest costs, reversal of impairment losses, cash flow hedges and accounting for equity investments.
Net profit under U.S. GAAP is higher by 10% as compared to net profit under IFRS in 2003, whereas it was lower by 2% in 2002 and 4% in 2001, as compared to net profit under IFRS for the same periods. In 2003, the primary reasons for a higher net profit under U.S. GAAP were adjustments resulting from the discontinuation (from January 1, 2002) of the amortization of goodwill arising from acquisitions under U.S. GAAP as well as from new agreements on early retirement during 2003 (see Note 37 to our Consolidated Financial Statements). In 2002, the primary reason for a lower net profit under U.S. GAAP were expenses for acquired research-in-process which are especially related to our acquisition of Collateral Therapeutics, Inc. and which are capitalized as part of goodwill under IFRS. A positive effect on net profit under U.S. GAAP resulted from the suspe nsion of amortizing goodwill in accordance with SFAS No. 142 as well as from the divestment of our interest in Aventis. In 2001, net profit under U.S. GAAP was primarily affected by expenses for acquired research-in-process.
A classification difference also arises in presenting interest relating to the pension obligations not transferred to external funds. Under IFRS, interest relating to the unfunded pension obligation is classified in financial result (see Note 9 to our Consolidated Financial Statements). Under U.S. GAAP, interest on pension obligations is considered a component of compensation expense. Accordingly, operating profit under U.S. GAAP would be lower and financial result higher by €35m in 2003, €44m in 2002 and €76m in 2001.
Inflation
During the past three years, the effects of inflation on our operations have not been material.
LIQUIDITY AND CAPITAL RESOURCES
For a discussion of our use of exchange-traded and over-the-counter derivative financial instruments to reduce currency and interest-rate risk resulting from anticipated transactions and from existing assets and liabilities, see Item 11 - "Quantitative and Qualitative Disclosures about Market Risk" and Note 31 to our Consolidated Financial Statements. We do not utilize commodity contracts.
Cash Flow Analysis
2003 compared to 2002
Operations
Cash flows before working capital changes totaled €766m, up 2% on the 2002 figure (€749m), whereas the underlying net profit before minority interest declined from €869m in 2002 to €446m in 2003. These contrary trends are due to the fact that material amounts contained in the net profit before minority interest last year were attributable to cash flows from investing activities, not to cash flows before working capital changes (disposal of Aventis CropScience and acquisition of the Leukine® development project). In addition, our share in the profit of Aventis CropScience in 2002 did not impact cash flows.
In 2003, working capital increased by €185m (2002: €165m). This increase was mainly driven by inventory increases relating to the supply chain of drospirenone, an active substance in Yasmin®, as well as to an increase in receivables due to a strong business in local currencies during the fourth quarter as compared with 2002. As a result, cash flows from operating activities totaled €581m (2002: €584m).
Investing
Cash flows used in investing activities amounted to €161m in 2003, compared with cash flows from investing activities of €685m in 2002. The cash outflows in the year under review were mainly due to the purchase of fixed assets. Proceeds from the disposal of fixed assets contained €43m from the sale of our remaining 49% stake in Oy Leiras Finland AB. The cash flows from investing activities reported in 2002 were mainly due to the proceeds from the disposal of our 24% interest in Aventis CropScience for €1.5bn. Purchases of fixed assets in 2002 included the cost of the manufacturing and marketing rights to Leukine® in its approved indications.
Financing
Cash flows used in financing activities amounted to €247m in 2003, as compared to €1,031m in the previous year. These cash flows mainly related to the distribution of a dividend of €180m paid in 2003 for the previous year (2002: €164m) as well as the purchase of treasury shares in the amount of €90m (2002: €234m). In addition, the decline in the cash flows used in financing activities was primarily due to a one-time contribution of €500m to the Schering Pension Trust in 2002.
2002 compared to 2001
Operations
In 2002, cash flows before working capital changes totaled €749m, an increase compared to 2001 (€653m). Other non-cash expenses and income included our share of the profit from Aventis CropScience of €45m (share of profit in 2001: €85m). The result from disposal of fixed assets mainly included income from the disposal of Aventis CropScience. Cash flows from operating activities declined 13% from €670m in 2001 to €584m in 2002, mainly as a result of increased inventories and receivables. In 2002 the change in inventories and receivables amounted to €251m. In terms of local currency, this was an increase in inventories and receivables by 11% which only slightly exceeded the increase in net sales by 10% in local currency terms.
Investing
In 2002, cash flows from investing activities amounted to €685m, compared with cash flows used in investing activities of €217m in 2001. This increase was mainly attributable to proceeds from the disposal of assets of €1.6 billion, particularly from the sale of our interest in Aventis CropScience. In July 2002, we acquired the sale and production rights for Leukine®, a product used in hematological oncology. At the same time, we assumed responsibility for the clinical development (phase II) of Leukine® for use in the treatment of Crohn’s disease. The acquisition costs amounted to €415m. Also in July 2002, we used treasury shares to acquire all outstanding shares of the U.S. biotech company Collateral Therapeutics, Inc. The cash outflow is shown under cash flows used for financing activities.
Financing
In 2002, cash flows used in financing activities amounted to €1,031m, compared with €535m in 2001. These cash flows were mainly related to the one-time contribution of €500m to the Schering Pension Trust (€300m in 2001), the purchase of treasury shares in the amount of €234m in connection with a capital reduction and the acquisition of Collateral Therapeutics in 2002, and the distribution of a dividend in the amount of €164m (2001: €198m).
Capital Resources
Net Cash Position
The Schering AG Group's cash and cash equivalents as of December 31, 2003, 2002 and 2001 amounted to €566m, €408m, and €192m, respectively. As of December 31, 2003, the Group had a positive net cash position (which it defines as cash and cash equivalents and marketable securities less bank loans and overdrafts) of €629m, compared with €566m as of December 31, 2002, and €62m as of December 31, 2001. This positive net cash position was partially due to pension liabilities from German retirement benefit plans, which are financial resources for the Group, and as of December 31, 2003, 2002, 2001, amounted to €458m, €439m and €911m, respectively. As the pension obligations in Germany usually remain unfunded, the Group, like most German companies, considers its unfunded pension obligations as long-term financing obligations. In 2001, Schering AG founded the Schering Altersversorgung Treuhand Verein ( Schering Pension Trust). One-time contributions amounting to €500m in 2002 and €300m in 2001 were transferred to the Schering Pension Trust; the provisions for pension obligations were reduced accordingly (see “-Contractual Obligations” and Note (24) to the Consolidated Financial Statements).
We hold our cash and cash equivalents primarily in euros. As of December 31, 2003 euro denominated liquid assets represented 80% of total cash and cash equivalents. U.S. dollar denominated cash and cash equivalents represented 6% of total liquid assets.
We expect that cash flows from operating activities, along with available cash and cash equivalents and marketable securities, will be sufficient to fund all of our anticipated operating needs in 2004, including capital expenditures, research cooperation projects, debt service and dividends.
Credit Lines
At December 31, 2003, the Schering AG Group had aggregate unused committed lines of credit of €81m (2002: €192m; 2001: €47m).
Borrowings
Borrowings are reflected in our Consolidated Financial Statements as Bank loans and overdrafts. Our bank loans and overdrafts are generally of a short term nature (maturity of less than one year). Bank loans and overdrafts as of December 31, 2003, amounted to €110m, compared with €91m as of December 31, 2002, and €233m as of December 31, 2001. €74m of these liabilities have a maturity of less than one year (December 31, 2002: €53m; December 31, 2001: €188m).
Share repurchase program
In 2003, we repurchased 2,500,000 shares for an amount of €90m.
In 2002, we repurchased 1,500,000 shares for an amount of €76m. In addition, approximately 2,500,000 shares were purchased and exchanged for shares of Collateral Therapeutics, Inc.
For information regarding shares acquired to be used for the share bonus program for employees, please refer to “Item 6 – Share Ownership – Employee Share Program”.
Recent acquisitions and dispositions
As part of our strategy, we seek to acquire both product rights and small to medium-sized enterprises in order to
expand our product portfolio,
acquire promising technical innovations, and
strengthen our presence on key geographical markets.
We dispose of assets or businesses from time to time that we decide do not belong to our core business.
Acquisitions
In the area of hematological oncology, we acquired exclusive rights to develop, sell and distribute MabCampath® in Japan, China and the Asian Pacific Basin from the U.S. biopharmaceutical company ILEX Oncology, Inc. in February 2003. We now have the worldwide marketing rights for this product which we have been marketing in the United States and Europe since 2001.
In July 2002, we acquired the marketing and production rights for Leukine®, a product used in hematological oncology. At the same time, we took over the rights to the phase II-development project for the use of Leukine® in Crohn’s disease. The acquisition cost for the entire transaction amounted to approximately €415m.
In July 2002, we acquired the U.S. biotech company Collateral Therapeutics, Inc., using our ADRs traded on the New York Stock Exchange as payment for the first time. The total value of ADRs issued on July 2, 2002, the date on which the shareholders of Collateral Therapeutics approved the offer, amounted to €148m.
In July 2002, we also acquired the Finnish company MAP Medical Technologies Oy. MAP specializes in the development, manufacture and marketing of radiopharmaceuticals for improving the diagnosis and therapy of cancer, as well as neurodegenerative diseases.
Dispositions
In the course of further focusing our business on core competencies, we sold the remaining 49% of Oy Leiras Finland AB to the Nycomed Group for €43m in May 2003. This transaction completed the divestiture of the domestic business of former Leiras Oy, which merged with our Finnish subsidiary Schering Oy.
At the beginning of June 2002, we sold our 24% stake in Aventis CropScience to Bayer AG for €1.5 billion.
In May 2002, we sold the general practitioner division of our subsidiary Asche AG to the Italian company Chiesi Farmaceutici S.p.A. as part of the strategic reorganization of the Schering AG Group’s German companies. In connection with this disposal, Asche AG was renamed AWAG Arzneimittelwerk Altona AG.
As of December 31, 2002 we reduced our interest in Oy Leiras Finland AB to 49%.
In December 2001, we increased our ownership interests in both the Jenapharm Group and the French radiopharmaceuticals company CIS bio international to 100%.
Also in December 2001, we signed a cooperation agreement with MorphoSys AG, Martinsried, Germany, to jointly develop antibody-therapeutics and in-vivo diagnostics. As part of this agreement, we will acquire a 10% ownership interest in MorphoSys AG.
Capital expenditures
We generally fund capital expenditures out of cash flows from operating activities.
Capital expenditures on property, plant, and equipment totaled €231m in 2003, compared with €281m in 2002 and €229m in 2001. The year-on-year decrease is due to exchange rate effects as well as measures initiated in 2003 to tighten structures and processes.
In the year under review, 59% of expenditures related to Germany, 14% to other countries in the European Union, 16% to the United States, and 2% to Japan. 53% of our total capital budget was spent on production, quality assurance, and environmental protection, and 25% on research and development. Marketing and selling and Other functions accounted for 22% of our investment budget.
In 2003, we continued consolidating the production of liquid and solid dosage forms, previously spread across two sites, at a single site in Berlin. We completed our substance library in Berlin, which is designed to support automated drug discovery in research.
We will increase capital expenditures to an anticipated total of €285m in the course of 2004 and, therefore, capital expenditures will be higher than in 2003. We will continue the construction of our new research building at our Berlin site. In production, a number of investments will be made to adapt our facilities to new products and markets, for example to commission new blister and packaging lines for contrast media cartridges. We will invest in infrastructure measures at our Bergkamen site to ensure compliance with regulatory and technical standards. We will continue to expand our pharmaceutical production plant in Weimar. Further investments are earmarked for the modernization of our radiopharmaceuticals production facility in Saclay, France.
In the United States, we plan to finish the construction of a flexible development plant at our research location in Richmond, California. The plant will enable us to produce biotechnological substances and small molecules in the amounts needed in clinical trials. In Seattle, we plan to expand our biotechnology production facilities for Leukine®.
Based on the multitude of ongoing projects, which will show notable payments in the coming years, we expect capital expenditure in 2005/2006 to remain at the same level as in 2004.
Contractual Obligations
The following table provides a maturity analysis of our on- and off-balance sheet contractual obligations as of December 31, 2003:
Contractual Obligations | Payments due by period |
---|
Total | Less than 1 year | 1-3 years | 3-5 years | More than 5 years |
---|
| (in € million) |
---|
Bank loans and overdrafts | 110 | 74 | 5 | 6 | 25 |
Operating Leases | 193 | 49 | 60 | 41 | 43 |
Purchase Obligations | 364 | 107 | 75 | 74 | 108 |
Long-term research and other agreements | 182 | 71 | 68 | 43 | - |
Other Long-Term Liabilities reflected on the balance sheet under IFRS including present value of expected payments to employees for unfunded pension obligations | 1,061 | 30 | 166 | 104 | 761 |
Total | 1,910 | 331 | 374 | 268 | 937 |
Contractual Obligations under Operating Leases, Purchase Obligations and Long-term research and other agreements are not recognized in the balance sheet. Purchase Obligations mainly arise from contractual agreements with various suppliers on minimum purchase quantities.
For further information on contingent liabilities, other financial commitments as well as commitments arising from research and other agreements see Note 32 to our Consolidated Financial Statements.
Dividends
In 2003, Schering AG paid a cash dividend of €0.93 per share for the financial year 2002 (in total €180m) and in 2002, a cash dividend of €0.83 per share for the financial year 2001 (in total €164m). The cash dividend paid in 2001 was €198m (€0.67 per share plus a bonus dividend of €0.33 per share). The primary purpose of additional bonus dividends paid in 2000 and 2001 was to enable German resident shareholders to benefit from certain tax advantages. The Executive Board will propose to the Annual General Meeting a dividend of €0.93 per share for the financial year 2003.
Restructuring Program
In the course of implementing our Global Production Strategy (GPS), we continued to restructure our worldwide pharmaceutical production. This should make our manufacturing network even more efficient and flexible, so that it is more market-demand driven and thus more competitive. The program consists of several sub-strategies, which aim to improve the production of active ingredients and of pharmaceutical, radiopharmaceutical, and biotechnological products. We continued to consolidate our pharmaceutical production sites in 2003. Four sites (Hamburg, Jena, Gemany; Vienna, Austria; Tammissari, Finnland) have been closed or sold in the interim, and two further sites (Buenos Aires, Argentina; Wayne, New Jersey) are in the process of being closed. Completion is scheduled for 2006. This restructuring will result in a network of 14 pharmaceutical sites wor ldwide, nearly all of which will be specialized in a single dosage form (liquids, solids, or semisolids). We have recognized provisions totaling €13m for future restructuring measures within the framework of our GPS. Provisions for restructuring largely include severance obligations to employees and other closure-related costs. We expect the restructuring to produce annual savings of around €13m.
Foreign Currency
Effective as of January 1, 1999, we adopted the euro as our reporting currency.
Sales made, and expenses incurred, by our subsidiaries located outside of Germany (and the other member countries of the European Union that have adopted the euro as their common currency) are generally denominated in local currency. As a consequence, a significant amount of our sales have been generated, and our costs have been incurred, in currencies other than the euro.
We made sales in a range of currencies during 2001, 2002 and 2003 as follows:
| Year ended December 31, |
---|
| 2003 | 2002 | 2001 |
---|
| (percentage of net sales) |
---|
Euro | 44 | 39 | 38 |
U.S. dollar | 26 | 27 | 25 |
UK pound sterling | 3 | 3 | 3 |
Japanese yen | 11 | 12 | 14 |
Brazilian real | 2 | 3 | 3 |
Other | 14 | 16 | 17 |
| 100 | 100 | 100 |
We translate the balance sheets of our subsidiaries that do not use the euro as their functional currency into euro at the mid-market rate on the balance sheet date. Income and expenses are translated at the average rate of exchange for the period. Comparability of our performance between financial periods can be significantly affected by fluctuations in the value of the euro against other currencies. Moreover, our financial condition and results of operations may be materially affected by movements in the exchange-rate between foreign currencies to which the Group is exposed and the euro. In general, due to translation effects, appreciation of the euro relative to a foreign currency has a negative effect on our reported consolidated net sales, operating profit and net profit. The depreciation of the euro relative to a foreign currency generally has a positive effect on our reported consolidated net sales, operating profit and net profit. The U.S. dollar, Japanese yen, British pound sterling and Brazilian real are the most significant sources of this currency translation risk. See Note 5 to our Consolidated Financial Statements.
Net sales in 2003 increased by 6% in local currency terms as compared to 2002. In euro terms, net sales decreased by 4% as compared to 2002. The negative translation effect was essentially due to the strengthening of the euro relative to the U.S. dollar and other currencies during 2003.
Net sales in 2002 increased by 10% in local currency terms and 4% in euro terms as compared to 2001. The negative translation effect was essentially due to the strengthening of the euro relative to the U.S. dollar during 2002.
For a discussion of the significant effects of foreign currency on our results of operations, see "-Results of Operations-2003 Compared with 2002-Results of Operations by Segment-United States Region", “-Latin America/Canada Region", "-Japan Region" and "-Asia/Middle East Region","-Results of Operations-2002 Compared with 2001- Results of Operations by Segment- United States Region”, “-Latin America/Canada Region", "-Japan Region" and "-Asia/Middle East Region".
Environmental Matters
Environmental laws and regulations impose stringent limitations on emissions and discharges to the environment from various manufacturing operations. In 2002 and 2003, we incurred capital expenditures of €15m and €15m, respectively, for environmental protection projects and other projects resulting in environmental benefits. Capital expenditures for environmental protection and other projects resulting in environmental benefits are forecasted to be between €5m and €15m for each of the years 2004 through 2008. In addition, our operation and maintenance costs for safety and environmental measures were €74m in 2002 and €76m in 2003. Operation and maintenance costs for each of the years 2004 through 2008 are forecasted to be between €76m and €80m.
We believe that the expenditures required to comply with applicable laws and regulations concerning environmental protection, including ongoing clean-up matters, will not have a material adverse effect on the Group's financial condition, cash flows or results of operations.
Risk Management
The information provided in this section contains forward-looking statements that involve inherent risks and uncertainties, principally with respect to unanticipated changes in foreign exchange or interest rates and changes in the level of our exposure to such market risks. Actual results may differ from those set forth in these forward-looking statements.
Market risk represents the risk of an adverse price change of a financial instrument, derivative or nonderivative, caused by fluctuations in interest rates, currency exchange rates, and equity prices. We have policies for managing potential exposures related to these risks. See Note 31 to our Consolidated Financial Statements.
We use exchange-traded and over the counter (OTC) derivative financial instruments to manage currency and interest rate risks resulting from business transactions and from interest rate and price changes on our portfolio. Transactions in derivative instruments are concluded with high-rated banks within fixed risk limits. Taking into account the hedged positions, we do not anticipate any material adverse effect on the Group's financial position, results of operations, liquidity or cash flows resulting from our use of derivative financial instruments.
Foreign exchange risk management
We have receivables and payables denominated in currencies other than the euro and the functional currencies of our foreign subsidiaries, which creates foreign exchange risk. Our most significant sources of currency risk are presently the U.S. dollar, Japanese yen and British pound sterling. We enter into foreign currency forward and option contracts to reduce our exposure to foreign currency fluctuations. Our currency risk includes balance-sheet assets denominated in foreign currencies and expected future net cash flows in foreign currencies for 12 months on a rolling basis.
See "Item 11-Quantitative and Qualitative Disclosure about Market Risk".
Legal Matters
The Group is involved in a number of legal proceedings and claims incidental to the normal conduct of its business, relating to such matters as product liability, patent infringement, tax assessments, competition, past waste disposal practices and release of chemicals into the environment. Although the outcome of these proceedings and claims cannot be predicted with certainty, Schering AG believes that any resulting liabilities, net of amounts recoverable from insurance or otherwise, will not, in the aggregate, have a material adverse effect on the Group's consolidated results of operations, financial condition and cash flows. For a discussion of certain legal proceedings in which we are involved, see "Item 8-Financial Information-Legal Proceedings."
RESEARCH AND DEVELOPMENT, PATENTS AND LICENCES
Our research and development activities are focused primarily on four selected fields with a high degree of unmet medical needs. We are concentrating on the exploitation of novel approaches resulting in the development of:
therapy of selected disabling and life threatening diseases.
sensitive and highly specific diagnostics.
gender specific health care products.
treatments of severe skin disorders.
For a discussion of our research and development activities and expenses, refer to “Item 4 – Information on the Company – Research and Development”. For a discussion of patents and other intellectual property, refer to “Item 4 – Information on the Company – Patents and Other Intellectual Property”.
OFF-BALANCE SHEET ARRANGEMENTS
We do not use "off-balance sheet financing arrangements", such as securization of receivables or access to assets through special purpose entities or variable interest entities. For a discussion of our accounting policy with respect to special purpose entities, refer to “Results of Operations - New Accounting Standards - U.S. GAAP”.
As of December 2003, we had issued financial guarantees of €27m (2002: €23m) which are related to transactions arising from the normal course of business.
Off-balance sheet contractual obligations are reported under “- Contractual Obligations”.
Table of Contents
DIRECTORS AND SENIOR MANAGEMENT
General
As required by the German Stock Corporation Act (Aktiengesetz), Schering AG has a two-tier board system consisting of a Supervisory Board (Aufsichtsrat) and an Executive Board (Vorstand).
The Executive Board is responsible for managing the business of Schering AG in accordance with the German Stock Corporation Act and the Articles of Association (Satzung) of Schering AG.
The principal function of the Supervisory Board is to supervise the Executive Board. The Supervisory Board is also responsible for appointing and removing the members of the Executive Board. The Supervisory Board may not make management decisions, but certain types of transactions require its prior consent.
In carrying out their duties, the members of the Supervisory Board and the Executive Board must exercise the standard of care of a diligent and prudent business person. In complying with this standard of care, the members must take into account a broad range of considerations, including the interests of Schering AG and our shareholders, employees and creditors. The members of the Supervisory Board and the Executive Board may be personally liable for violation of their duties.
Supervisory Board
Our present Supervisory Board consists of 16 members, 8 of whom are elected by our shareholders by a simple majority of the votes cast at a shareholder meeting in accordance with the provisions of the German Stock Corporation Act, and 8 of whom are elected by our employees in accordance with the German Co-Determination Act (Mitbestimmungsgesetz).
A member of our Supervisory Board elected by our shareholders may be removed by our shareholders by a majority of the votes cast at a meeting of shareholders. A member of the Supervisory Board elected by our employees may be removed by three-quarters of the votes cast by the relevant class of employees. The Supervisory Board appoints a Chairman and a Vice- Chairman from among its members. At least half the total required number of members of the Supervisory Board must be present or participate in the decision making to constitute a quorum. Unless otherwise provided for by law, resolutions are passed by a simple majority of the votes cast. In the event of a tie, another vote is held and, in the case of a second tie, the Chairman (who is, in practice, a representative of the shareholders because the representatives of the shareho lders have the right to elect the Chairman if two-thirds of the total required number of members of the Supervisory Board fail to agree on a candidate) then has a casting vote.
The members of our Supervisory Board are each elected for the same fixed term of approximately five years. If a member is elected to replace a retired member, its term will expire at the same time. The term of our current members of the Supervisory Board will expire at the end of the Annual General Meeting 2004. Re-election is possible.
The remuneration of the members of the Supervisory Board is determined by our Articles of Association.
The current members of our Supervisory Board, their respective ages as of February 28, 2004, their principal occupation and the year in which they were first elected to our Supervisory Board and by whom they were elected are as follows:
Name | Age | Principal occupation | Year first elected by shareholders (S) employees (E) |
---|
Dr. Giuseppe Vita Chairman of the Supervisory Board | 68 | | 2001 (S) |
Norbert Deutschmann Vice-Chairman of the Supervisory Board | 52 | Chairman of the Berlin Works Council, Schering AG, Berlin | 1999 (E) |
Dr. rer. oec. Karl-Hermann Baumann | 68 | Chairman of the Supervisory Board of Siemens AG, Berlin and Munich | 1994 (S) |
Prof. Dr. med. Piet Borst | 69 | Professor of Clinical Biochemistry, University of Amsterdam, Amsterdam | 2000 (S) |
Dr. Mathias Döpfner | 41 | Chairman of the Executive Board of Axel Springer Verlag AG, Berlin | 2001 (S) |
Professor John A. Dormandy | 66 | Professor of Vascular Sciences, University of London; Director, Vascular Clinical Research Unit, St.George’s Hospital, London | 1996 (S) |
Joachim Elsholz | 54 | Head of Berlin Liaison Office of Industriegewerkschaft Bergbau, Chemie, Energie, Berlin | 2000 (E) |
Dr. rer. pol. Reiner Hagemann | 56 | Chairman of the Executive Board of Allianz Versicherungs-AG, Munich | 1997 (S) |
Johannes Heitbaum | 40 | Vice Chairman of the Bergkamen Works Council, Schering AG, Berlin | 1999 (E) |
Dr. h.c. Martin Kohlhaussen | 68 | Chairman of the Supervisory Board of Commerzbank AG, Frankfurt/Main | 1996 (S) |
Hermann-Josef Lamberti | 48 | Member of the Executive Board of Deutsche Bank AG, Frankfurt/Main | 2001 (S) |
Dr. med. Hans-Peter Niendorf | 57 | Head of Corporate Clinical Development Diagnostics& Radiopharmaceuticals, Schering AG, Berlin | 1999 (E) |
Hans-Jürgen Scheel | 60 | Corporate Human Resources, Schering AG, Berlin | 1994 (E) |
Günter Schmitt | 61 | Member of the Berlin Works Council, Schering AG, Berlin | 1999 (E) |
Dr. rer. oec. Ulrich Sommer | 56 | Area Manager Marketing Europe Region, ScheringAG, Berlin | 1999 (E) |
Heinz-Georg Webers | 44 | Chairman of the Central Works Council of Schering AG; Chairman of the Bergkamen Works Council, Schering AG, Berlin | 1999 (E) |
Executive Board
Our Executive Board currently consists of 6 members. Under our Articles of Association, our Supervisory Board determines the size of the Executive Board, although it must have at least two members.
Any two members of the Executive Board or one member of the Executive Board and the holder of a special power of attorney (Prokura) may legally represent Schering AG towards third parties.
The Executive Board reports regularly to the Supervisory Board, including with respect to proposed business policy or strategy, profitability, the current business of Schering AG, deviations from plan, risk management, business transactions that may affect the profitability or liquidity of Schering AG, and any exceptional matters which arise from time to time. The Supervisory Board may also request special reports from the Executive Board.
The Supervisory Board appoints each member of the Executive Board for a maximum term of five years. Executive Board members may be reappointed or have their term extended for one or more terms of up to five years each. The Supervisory Board may remove a member of the Executive Board prior to the expiration of his term if he commits a serious breach of duty or is incapable of carrying out his duties or if there is a bona fide vote of no confidence by a majority of the votes cast at an annual general meeting.
A member of the Executive Board may not vote on matters relating to certain contractual arrangements between the member and the Schering AG Group and may be liable to Schering AG if the member has a material interest in any contractual agreement between the Schering AG Group and a third party which was not disclosed to, and approved by, the Supervisory Board.
The current members of our Executive Board, their respective ages as of February 28, 2004, their positions, the years in which they were first appointed to our Executive Board and the years in which their terms expire, respectively, are as follows:
Name | Age | Position | Year first appointed | Year term expires |
---|
Dr. Hubertus Erlen | 60 | Chairman of the Executive Board; responsibilities: strategy and business development, corporate communication, senior executives, corporate auditing | 1985 | 2005 |
Dr. Ulrich Köstlin | 51 | Member of the Executive Board; responsibilities: marketing and sales, supply chain and environment, Europe, Africa | 1994 | 2009 |
Mr. Lutz Lingnau | 60 | Member of the Executive Board; responsibilities: Specialized Therapeutics, Dermatology, North America | 2001 | 2005 |
Dr. Marc Rubin | 49 | Member of the Executive Board; responsibilities: development | 2003 | 2008 |
Dr. Jörg Spiekerkötter | 45 | Member of the Executive Board; responsibilities: finance and administration, information technology, human resources, Latin America | 2002 | 2007 |
Prof. Dr. Dr. h.c. Günter Stock | 60 | Member of the Executive Board; responsibilities: research, Gynecology&Andrology, Diagnostics&Radiopharmaceuticals, Japan, Asia, Australia | 1989 | 2009 |
Dr. Hubertus Erlen began his career with Schering AG in 1972 in a pharmaceutical manufacturing function. In 1978 he joined the central office of the Executive Board, which he later headed. Subsequently, he served as a member of the former Electroplating Divisional Board, among other things, in the United States. In 1985, Dr. Erlen was appointed as a member of the Executive Board of Schering AG, and was, among other things, responsible for the region North America as well as for Production and Human Resources. In April 2001, Dr. Erlen became Chairman of the Executive Board.
Dr. Ulrich Köstlin began his career with Schering AG in 1982 as a management trainee. He served as general manager for several subsidiaries of Schering AG in Latin America from 1983 to 1986. Subsequently he was appointed the head of the pharma division for Latin America and Canada. Prior to his appointment as a member of the Executive Board of Schering AG in 1994, he served from 1990 to 1993 as vice president of Berlex Laboratories, Inc., USA, and as a member of the Pharma Executive Committee of Schering AG from 1993 to 1994.
Mr. Lutz Lingnau joined Schering AG's business trainee program in 1966. From 1968 to 1989, he served in various capacities at Schering AG and in a number of subsidiaries in South America and the United States, including as president of Berlex Laboratories, Inc., from 1983 to 1985. Since 1989, Mr. Lingnau is the president and Chief Executive Officer of Schering Berlin Inc., USA. He was appointed as a member of the Executive Board of Schering AG effective January 1, 2001.
Dr. Marc Rubin, joined Schering AG from GlaxoSmithKline in 2003. He started his career at the National Institutes of Health, on the senior staff of the National Cancer Institute. He joined Glaxo, Inc. in 1990 as Director of Infectious Diseases Clinical Research in the USA. In his time at GlaxoSmithKline, Dr. Rubin held positions of responsibility in global clinical and commercial development overseeing programs in the USA, Europe, Asia and Latin America. In 2001, he was Senior Vice President of Global Clinical Pharmacology & Discovery Medicine. Dr. Rubin was appointed as a member of the Executive Board of Schering AG on October 1, 2003 and is responsible for development, leading Schering AG's Preclinical and Clinical Development as well as Global Regulatory Affairs.
Dr. Jörg Spiekerkötter joined Schering AG in 1999 as head of Finance. Prior to joining Schering AG, Dr. Spiekerkötter was head of Legal, Trade Mark, Insurance at Hoechst Schering AgrEvo GmbH, Berlin, from 1994 to 1999. Dr. Spiekerkötter was appointed as a Deputy Member of the Executive Board of Schering AG in April 2002. In April of 2003, Dr. Spiekerkötter was appointed Chief Financial Officer and member of the Executive Board.
Prof. Dr. Dr. h.c. Günter Stock joined Schering AG in 1983 as head of the former Cardiovascular Pharmacology Department. From 1987 to 1989, he served as head of the Institute for Pharmacology. Prof. Dr. Stock was appointed as a member of the Executive Board of Schering AG in 1989.
Other Senior Management
Mr. José E. Martino Alba joined Schering AG in1983. From 1983 to 1989, he held several positions with Schering AG in Spain and South America including plant manager in Venezuela and Colombia. From 1989 to 1991, he served as a project manager for the European production subsidiaries of Schering AG. From 1991 to 2002, he was chairman of the board and managing director of Schering’s subsidiaries in China and Hong Kong. In September 2002, Mr. Martino was appointed as the representative director and president of Nihon Schering K.K.
Dr. med. habil. Joachim-Friedrich Kapp joined Schering AG in 1975 as a scientist. From 1975 to 1983, Dr. Kapp served in various capacities at the Schering AG Group, including as vice president of research and development of Berlex Laboratories, Inc. From 1984 to 1991, he was employed by Gödecke AG where he held several positions, including head of research and development. In 1991, Dr. Kapp returned to the Schering AG Group where he currently serves as head of Specialized Therapeutics.
Mr. Christian Nowak began his career at Schering AG in 1968 in the agrochemicals division. From 1968 to 1989, he held various positions in the area of agrochemicals, including head of sales and marketing and member of the agrochemicals management board. From 1989 to 1991, he served as director of sales and marketing and member of the pharmaceuticals management board. Mr. Nowak is currently the head of the Europe Region, a position he has held since 1991.
Dr. Philip Smits joined Schering AG in the beginning of 2003 as head of the Gynecology&Andrology business area. He has served for over thirteen years in various clinical research and medical management functions at Eli Lilly and Company in Europe and North America as well as at Aventis Pharmaceuticals Inc., Bridgewater, New Jersey and has a technical track record in endocrinology, infectious diseases and osteoporosis.
Mr. Hans-Michael Rook began his career at Schering AG in 1967 as a business trainee. He served in numerous capacities within the Schering Group, including from 1979 to 1985 as head of pharma portfolio and marketing planning of Nihon Schering K.K. and from 1991 to 1997 as head of marketing and business development for the Europe Region at Schering AG. Mr. Rook currently serves as head of Diagnostics&Radiopharmaceuticals.
Mr. Reinhard Franzen joined Schering AG in 1983 and has managed a variety of marketing, medical affairs and operational departments. He has gained his experience working in many countries including Thailand, the Phillipines, Germany and the United States. Most recently, Mr. Franzen served as Vice President and General Manager of the female health care business unit in the United States. In 2003 he became president and Chief Operating Officer of Berlex Laboratories, an operating unit of Berlex Inc.
Prof. Dr. Wolfgang Kehr joined Schering AG in 1970 as a research scientist. In 1985 he became head of Schering’s pharmaceutical research and served as a member of the executive committee of its pharma division. In 1988 he became a member of the board of Berlex Laboratories, Inc. Since 1991 he served as head of Schering’s dermatology and oncology business unit and later as Vice President and General manager of Berlex’s Therapeutics East business unit. In May 2003, Prof. Kehr was appointed managing director of the Center of Dermatology, Schering AG.
COMPENSATION
The aggregate remuneration (including compensation, benefits in kind and contingent or deferred compensation accrued) of all members for their service on the Supervisory Board for 2003 amounted to €3,092,018 and is comprised of the following components:
Name | Fixed compensation | Variable compensation | Compensation for committees |
---|
| € thousand | € thousand | € thousand |
---|
Dr. Giuseppe Vita (Chairman of the Supervisory Board) | 7 | 298 | 76 |
Other members of Supervisory Board | 51 | 2,267 | 393 |
Total | 58 | 2,565 | 469 |
In addition to reimbursement of out-of-pocket expenses, the members of the Supervisory Board receive an aggregate fixed annual payment of €60,000 plus an aggregate variable annual payment that depends on the amount of dividends paid to the shareholders of Schering AG. For each €0.05 dividend per share paid over and above a base amount of €0.10 dividend per share, the aggregate variable compensation component amounts to €210,000. A member of the Supervisory Board also has received an annual fee for consultancy services, see "Item 7-Related Party Transactions".
The aggregate remuneration (including compensation, benefits in kind and contingent or deferred compensation accrued) of all members of the Executive Board for 2003 amounted to €11,163,990 and is comprised of the following components:
Name | Fixed compensation | Variable compensation | Exercise stock-based compensation plan |
---|
| € thousand | € thousand | € thousand |
---|
Dr. Hubertus Erlen (Chairman) | 544 | 1,638 | – |
Other members of Executive Board | 2,150 | 6,716 | 116 |
Total | 2,694 | 8,354 | 116 |
The maximum number of shares that can be received by the members of the Executive Board under the provisions of the stock-based compensation plans is as follows:
Name | Stock-based compensation plan LTI Plan 2000 | Stock-based compensation plan LTI Plan 2001 I/II/III |
---|
Dr. Hubertus Erlen (Chairman) | 22,500 | 60,000 |
Other members of Executive Board | 54,000 | 244,000 |
Total | 76,500 | 304,000 |
Employees who are elected as members of the Supervisory Board in accordance with the German Co-Determination Act maintain their pension, retirement and similar benefits while serving on the Board. The aggregate amount set aside or accrued by the Schering AG Group to provide pension, retirement or similar benefits to the employees who are currently members of the Supervisory Board amounted to €1,677,456. As of December 31, 2003, the total amount set aside or accrued by the Schering AG Group to provide pension, retirement or similar benefits to current and retired members of the Executive Board amounted to €35,653,324.
Stock-Based Compensation Plans
The Long Term Incentive Plan 2001
In 2001, we established the Long Term Incentive Plan 2001. The program is comprised of up to three annual tranches. The plan has a duration of seven years, and share options awarded under the plan vest over three years.
In May 2001 we made grants of share options (LTI Plan 2001/I) to approximately 650 participants worldwide in two categories: a Top Executives group of approximately 60 participants and a Key Managers group of approximately 590 participants.
Participants in the Top Executives group received share options with an exercise price of €54.66 per share (average share price on the date of grant). The options can only be exercised if, at the time of exercise, the share price has increased by at least 30% or has outperformed the MSCI World Pharmaceutical & Biotechnology Index since the inception of the tranche for 2001. Participants in the Top Executives group are required to make a personal investment in, and hold until the time of exercise, one share for every ten share options that they are granted.
Participants in the Key Managers group received share options with an exercise price of €60.13 per share (a 10% premium over the average share price on the date of grant). Participants are not required to make a personal investment in shares. Other than for the three-year vesting period, there are no other conditions to exercise of the share options by participants in the Key Managers group.
In May 2002 the second tranche of the long term incentive program 2001 (LTI Plan 2001/II) was established, with approximately 60 participants in the Top Executives group and approximately 770 participants in the Key Managers group. The exercise price of the options of the second tranche are €66.48 (Top Executives) and €73.13 (Key Managers).
In May 2003, the third tranche of the long term incentive program 2001 (LTI Plan 2001/III) was established with approximately 60 participants in the Top Executives group and approximately 850 participants in the Key Managers group. The exercise price of the options of this tranche are €40.18 (Top Executive) and €44.20 (Key Managers).
The Annual General Meeting of Shareholders approved a resolution on April 26, 2001 authorizing a €5m conditional increase in our share capital in order to provide newly issued shares for exercises of share options under the Long Term Incentive Plan 2001.
The Long Term Incentive Plan 2000
In 1999, we established the Long Term Incentive Plan 2000. We offered approximately 270 eligible key executives worldwide the opportunity to participate in the plan. Eligibility was based on the position and expected long term individual performance of the participant and prospective continued employment with us for the next two years. The plan has a duration of seven years and expires on December 31, 2006.
Under this plan, participants who make a personal investment in our shares and hold these shares for a minimum of three years are entitled to receive one option right for each eighteen shares purchased. A minimum of five option rights, requiring the purchase of ninety shares, is needed to participate in the plan. A maximum number of option rights has been determined for each eligible plan participant.
Option rights cannot be exercised within the first three years of the effective date of the plan. Option rights can be exercised from the first trading day in 2003 until the last trading day in 2006. Option rights cannot be exercised during a three-week period prior to the release of corporate earnings information. Any option rights that have not been exercised at the end of the exercise period will be exercised automatically on the last trading day in 2006. Upon exercise of the option rights, the participant is entitled to receive award shares. The award shares that the Company provides to the participants are purchased in the open market.
The number of award shares that a participant receives upon the exercise of option rights depends on certain performance measures. One option right entitles the participant to receive three award shares for each 2% increase in the value of the shares (for this purpose this includes absolute stock price changes plus dividends paid) over the opening stock price on the effective date of the plan. Members of the Executive Board can receive award shares due to this performance measure only if, at the time of exercise, the value of the shares has increased at least by 30%. In addition, one option right entitles the participant to receive three award shares for each 1% by which the shares outperform the STOXX Healthcare over the relevant period. STOXX Healthcare is a European industry stock index which measures the performance of 34 p harmaceutical companies, including Schering AG. The maximum number of award shares that a participant can receive for each option right under either performance category is ninety shares. Therefore, a participant can receive a maximum of 180 award shares for one option right or eighteen shares of personal investment.
In connection with the plan, we have purchased 814,860 call options on Schering AG's shares at a strike price of €39.40 per share. As of December 31, 2003, 513,000 of these purchased options were remaining in our portfolio.
The following table sets forth, as of December 31, 2003, certain information relating to the Long Term Incentive Plan 2000:
Plan | Initial exercise date | Expiration date | Number of options outstanding | Maximum number of award shares |
---|
2000 Plan | January 1, 2003 | December 31, 2006 | 2,840 | 511,200 |
The following table summarizes certain information relating to the Long Term Incentive Plan 2001:
Plan | Initial exercise date | Expiration date | Exercise price € | Number of options granted/remaining |
---|
LTI Plan 2001/I | May 2, 2004 | May 1, 2008 | | |
-"Top Executives" group | | | 54.66 | 413,500/406,500 |
-"Key Managers" group | | | 60.13 | 812,100/764,400 |
LTI Plan 2001/II | May 2, 2005 | May 1, 2009 | | |
-"Top Executives" group | | | 66.48 | 411,000/398,000 |
-"Key Managers" group | | | 73.13 | 1,040,500/1,000,800 |
LTI Plan 2001/III | May 2, 2006 | May 1, 2010 | | |
-“Top Executives” group | | | 40.18 | 420,700/417,700 |
-"Key Managers" group | | | 44.20 | 1,173,000/1,160,400 |
BOARD PRACTICES
The employment agreements of the members of the Executive Board do not provide for benefits upon termination of employment.
The Supervisory Board has established a number of committees, including an executive committee, a research and development committee, an audit committee and a nomination and compensation committee.
The members of the executive committee are Dr. Giuseppe Vita (chairman), Norbert Deutschmann, Dr. Reiner Hagemann, and Heinz-Georg Webers. The executive committee acts on urgent matters in between the sessions of the full Supervisory Board.
The members of the research and development committee are Dr. Giuseppe Vita (chairman), Prof. Piet Borst, Norbert Deutschmann, Prof. John A. Dormandy, Dr. Hans-Peter Niendorf and Dr. Ulrich Sommer. The research and development committee regularly discusses key research and development issues, in particular regarding objectives, priorities and organization.
The members of the audit committee are Dr. Karl-Hermann Baumann (chairman), Norbert Deutschmann, Dr. Giuseppe Vita and Heinz-Georg Webers. The audit committee prepares the Supervisory Board’s recommendation on the auditor to be elected by the Annual General Meeting and enters into the contract with such auditor. As described under “Item 16.C - Principal Accountant Fees and Services” -, the audit committee also approves the engagement of the auditor to perform any non-audit services. It reviews the quarterly financial statements and the risk management system of the company. It reviews annual financial statements and issues a recommendation to the full Supervisory Board as to their adoption.
The members of the nomination and compensation committee are Dr. Giuseppe Vita (chairman), Norbert Deutschmann, Dr. Reiner Hagemann and Hans-Jürgen Scheel. The nomination and compensation committee is responsible for searching and reviewing candidates for election to the Executive Board. It reviews and approves the salaries and other terms and conditions of employment of the members of the Executive Board, as well as all other contracts with members of the Executive Board and the Supervisory Board.
EMPLOYEES
The annual average of employees by the Group during 2001, 2002 and 2003 was 23,720, 25,056 and 26,245, respectively. As of December 31, 2003, we employed 26,364 persons. The following tables set forth, as of December 31, 2003, a breakdown of our employees by the main category of activity and by geographic area:
Category of activity: | Number |
---|
Administration | 4,147 |
Research and development | 4,695 |
Production | 8,900 |
Marketing and sales | 8,632 |
Total | 26,374 |
Geographic areas: | Number |
Schering AG | 8,283 |
Europe Region | 8,196 |
United States Region | 3,711 |
Japan Region | 1,560 |
Latin America/Canada Region | 2,456 |
Asia/Middle East Region | 1,358 |
Other employees | 810 |
Total | 26,374 |
The decrease in the number of persons employed by the Group in 2003 was mainly due to disposal of Oy Leiras Finland AB, Finland. In addition, the acquisitions of Collateral Therapeutics, Inc., and MAP Technology as well as the integration of production and research facilities in connection with the acquisition of Leukine®, contributed to the increase. We do not employ a significant number of temporary employees.
Labor Relations
Europe Region
We believe that a significant number of our employees in the Europe Region are presently represented by trade unions. Labor relations in the Europe Region have been good and we have not experienced any material work stoppages in recent years.
Wages and general working conditions are generally the subject of centrally negotiated collective bargaining agreements. Within the limits established by these agreements, the operating companies of the Group negotiate directly with unions and other labor organizations representing our employees. Collective bargaining agreements relating to remuneration typically have a term of one year.
In addition to trade unions, we also consult from time to time with various local, national and European work councils. Employees generally elect the members of work councils. These work councils primarily serve an advisory role. However, under certain circumstances, we may be required to consult with one or more of the work councils before proceeding with a course of action. Furthermore, we are obliged to inform the work councils of activities which affect our workforce in Europe.
Other Regions
Our employees in the United States, Latin America/Canada and Asia/Middle East Regions are generally not either represented by trade unions or employed pursuant to collective bargaining agreements. In the Japan Region, approximately half of our employees are represented by company labor unions. Labor relations in these Regions have been good and we have not experienced any material work stoppages in recent years.
SHARE OWNERSHIP
Employee Share Program
Schering AG and many of its subsidiaries have established an Employee Share Program and offer Schering AG shares to the employees at subsidized prices. The scope of this program has been enlarged in recent years to include most of the subsidiaries worldwide. The program was continued in 2003 with approximately 0.4 million shares being bought by the employees.
Share Ownership by Directors
No member of the Supervisory Board or the Executive Board beneficially owns 1% or more of the outstanding shares.
Dr. Reiner Hagemann, a member of our Supervisory Board, is the Chairman of the Executive Board of Allianz Versicherungs-AG, which is an affiliate of Allianz AG (which Schering AG has been informed holds approximately 12.2% of our outstanding shares). Dr. Hagemann disclaims beneficial ownership of such shares.
Hermann-Josef Lamberti, a member of the Supervisory Board, is a member of the Executive Board of Deutsche Bank AG (which Schering AG has been informed holds approximately 3.4% of our outstanding shares). Mr. Lamberti disclaims beneficial ownership of such shares.
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MAJOR SHAREHOLDERS
As of February 10, 2004, Schering AG had an aggregate of 194,000,000 shares outstanding.
The shares are issued only in bearer form. Therefore, we are unable to determine how many shareholders we have and how many shares a particular shareholder owns. Although we are unable to determine the exact number of our shares held in the United States, we believe that as of November 14, 2003, approximately 13% of the shares were held in the United States. As of January 30, 2004, there were 1,345 registered holders of American Depositary Receipts (ADRs) under our sponsored program with JP Morgan Chase Bank. The ADRs are listed on the New York Stock Exchange, and each ADR represents one share. One of the registered holders is the Depository Trust Company, which represents the total number of ADRs held in book-entry-form. The ADR holders collectively held 3,316,047 ADRs, or approximately 1.7% of the total issued shares as of Ja nuary 30, 2004.
Under Section 21 of the German Securities Trading Act (Wertpapierhandelsgesetz), holders of voting securities of a German company (including Schering AG) admitted to official trading on a stock exchange within the European Union or the European Economic Area are obliged to notify promptly in writing the company and the German Federal Supervisory Authority for Financial Services (Bundesanstalt für Finanzdienstleistungsaufsicht) of the level of their holdings whenever such holdings reach, exceed or fall below certain thresholds. These thresholds are set at 5%, 10%, 25%, 50% and 75% of a company's outstanding voting rights. If a shareholder fails to notify the company as required, the shareholder will be disqualified from exercising the voting rights attached to its shares, for so long as such failure continues. The German Securities Trading Act contains various rules designed to ensure the attribution of shares to the person who has effective control over the shares.
Schering AG has been informed that as of February 13, 2004, Allianz AG had direct or indirect share holdings representing approximately 12.2% of the outstanding shares. Schering AG has also been informed that as of February 13, 2004, Deutsche Bank AG (through various investment funds and other entities) beneficially owned shares representing 3.4% of the outstanding shares. Major shareholders do not have different voting rights.
To the extent known to us, the Schering AG Group is not owned or controlled directly or indirectly by any corporation, foreign government or any person, jointly or severally.
RELATED PARTY TRANSACTIONS
Shareholders
Allianz Versicherungs-AG currently provides insurance services to the Schering AG Group in a number of different areas such as liability, property, business interruption, directors' and officers' liability, marine, personal accident and automobile insurance. Deutsche Bank AG provides us with a variety of financial services in the ordinary course of business. We believe that these services are provided on an arm's length basis.
Directors
Certain members of the Supervisory and Executive Boards are members of the supervisory boards of various financial institutions with which we engage in transactions in the ordinary course of business.
Professor John A. Dormandy, a member of the Supervisory Board, has provided consultancy services to Schering AG in connection with research relating to certain cardiovascular indications since June of 1996. For these services Prof. Dormandy has received a fee of €56,242 plus expenses of €2,272 in 2003.
Professor Dr. Piet Borst and Professor John A. Dormandy are members of the Curatorium of Schering Forschungsgesellschaft mbH, a 100% subsidiary of Schering AG. In such capacity, they have received in 2003 €1,000 and €2,000, respectively, as fees for attending meetings.
There was a loan with a balance of €30 thousand to one member of the Supervisory Board as of December 31, 2003 (repayments in 2003 amounted to €3 thousand). Interest of 6% is charged on the loan, which is repayable over 13 years. A loan previously granted to a member of the Executive Board was redeemed completely during the reporting period. All such loans have been granted prior to July 29, 2002 and have not been amended or extended since then.
According to section 15a of the German Securities Trading Act (”Wertpapierhandelsgesetz”), the members of the Executive or the Supervisory Board of Schering AG have to notify transactions in securities of their own company. This applies to transactions whose aggregate value terms of the total number of transactions carried out by the party subject to the disclosure requirement within 30 days exceeds €25 thousand. The same obligation applies to transactions of close relatives. During fiscal year 2003, Schering AG has been notified of a total of 12 transactions. In accordance with section 15a of the German Securities Trading Act, Schering AG has promptly disclosed these transactions on its web site. Members of the Supervisory Committee and their relatives have purchased 5,000 Schering AG shares and have sold 1,000 shares. The same group has purchased 9,500 call options on Schering AG shares and has sold the same amount. Members of the Executive Committee and their relatives have purchased 6,000 shares and have sold 2,700 call options. A complete list with all details of the notified transactions is available in the data bases of the German Federal Authority for Financial Services Supervision (Bundesanstalt für Finanzdienstleistungsaufsicht) under www.bafin.de.
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LEGAL PROCEEDINGS
The Group is involved in a number of legal proceedings and claims incidental to the normal conduct of its business, relating to such matters as product liability, patent infringement, tax assessments, competition, past waste disposal practices and the release of chemicals into the environment. Although the outcome of these proceedings and claims cannot be predicted with certainty, Schering AG believes that any resulting liabilities, net of amounts recoverable from insurance or otherwise, will not, in the aggregate, have a material adverse effect on the Group's consolidated results of operations, financial condition and cash flows. What we believe to be the most significant of these proceedings and claims are described below.
The Group's Brazilian subsidiary is a defendant in approximately 460 civil actions brought in courts in Brazil by women, suing individually and claiming that they became unintentionally pregnant. Most of them claim that they became unintentionally pregnant after taking placebo pills packaged by the subsidiary in connection with test runs of a new packaging machine between January and April 1998. Most of these claims are still pending. In the majority of the judgments obtained to date, the claims were rejected by the Brazilian courts. In connection with this incident, two managers of the Group's Brazilian subsidiary were convicted in a Brazilian court for the failure to label properly the pouches and blisters for the placebo pills. The Brazilian court imposed a minor fine.
In November 1998, Medrad, Inc., one of the Group’s subsidiaries in the United States, was sued by Liebel-Flarsheim, Inc. which alleged patent infringement, antitrust violations and tortious interference with contractual relations. In October 2001 and February 2002, the U.S. District Court for the Southern District of Ohio, on summary judgement motions, decided in favor of Medrad regarding Liebel-Flarsheim’s patent infringement claims. Liebel-Flarsheim appealed the decision of the U.S. District Court and the Federal Circuit Court of Appeals reversed the District Court’s decision and remanded it back to the District Court in february 2004. All claims other than the patent claims were withdrawn by Liebel-Flarsheim in connection with a settlement reached in October 2002.
The Group’s subsidiary in the United States, Berlex Inc., was named as a defendant with 30 other pharmaceutical companies in cases filed by Suffolk County and Westchester County, New York, in January and August 2003, respectively. The two lawsuits contain virtually identical allegations that pharmaceutical companies have overcharged each county for prescription medications paid for by New York State’s Medicaid program by reporting artificially inflated “average wholesale prices” for their drug products for the purpose of government reimbursement. Each county seeks a variety of unspecified damages from the various pharmaceutical companies. The cases have been consolidated into a multidistrict litigation in the District of Massachusetts In Re Pharmaceutical Industry Average Wholesale Price Litigation (MDL 1456). Berlex intends to v igorously defend itself against the allegations made in the lawsuit, and a dismissal motion is currently pending.
Following the sale of Schering’s share in Aventis CropScience to Bayer AG, Bayer CropScience AG has initiated arbitration proceedings alleging the violation of a financial statement guarantee for which Bayer CropScience AG is demanding payments of damages. It cannot be reasonably estimated at the date of this annual report whether the underlying facts justify such a claim and, if so, to what extent the Group would be liable. Bayer CropScience AG has further notified Schering AG in several other cases about potential violations of provisions of the Aventis CropScience Stock Purchase Agreement that might lead to damages. With respect to these claims, it cannot be estimated whether and to what extent the Group would be liable.
A U.S. citizen has filed an action against Schering and Bayer AG in a New York court. The plaintiff claims damages for forced sterilization and cruel treatment suffered at the Auschwitz concentration camp during World War II. To our knowledge and belief, there is no factual information suggesting that Schering could in any way have been involved in this matter. Schering also believes that this claim cannot be asserted against an individual company, but should be addressed to the “Remembrance, Responsibility and the Future” Foundation. This foundation has been endowed with funds of more than 5 billion euros by German companies (including Schering) and the German Federal Government. The beneficiaries of compensation grants paid by the foundation include victims of human experiments in concentration camps. Schering considers the claims assert ed to be unjustified and expects that the action will be dismissed.
SIGNIFICANT CHANGES
Except as otherwise disclosed in this annual report, there has been no material adverse change in the financial position of Schering AG since December 31, 2003.
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LISTING DETAILS
Stock Price History
The table below sets forth, for the periods indicated, the high and low intraday prices for the shares on the Frankfurt Stock Exchange, as reported by the Frankfurt Stock Exchange, and as adjusted to give effect, retroactively, to Schering AG's three-for-one share split effective on June 1, 2000, and the high and low prices of the American Depositary Receipts (ADRs), each representing one share, which were listed on the New York Stock Exchange (NYSE) on October 12, 2000. See the discussion under "Item 3-Key Information-Exchange-Rates" with respect to rates of exchange between the U.S. dollar and the euro applicable during the periods set forth below. While Schering AG's shares are also listed on the London and Zurich stock exchanges, the trading volume of the shares outside of Germany is negligible. Therefore, providi ng stock price information for these trading markets would not be meaningful.
| New York Stock Exchange price per ADS | Frankfurt Stock Exchange price per share |
---|
| High | Low | High | Low |
---|
| ($) | (€) |
---|
| | | | |
1999 | | | | |
Annual | | | 42.83 | 31.87 |
2000 | | | | |
Annual | 60.50 | 50.25 | 75.80 | 37.40 |
2001 | | | | |
First Quarter | 50.38 | 45.70 | 62.00 | 49.03 |
Second Quarter | 56.45 | 47.10 | 66.60 | 53.00 |
Third Quarter | 55.30 | 43.50 | 62.88 | 46.61 |
Fourth Quarter | 56.46 | 49.35 | 62.90 | 52.63 |
Annual | 58.38 | 43.50 | 66.60 | 46.61 |
2002 | | | | |
First Quarter | 61.25 | 50.24 | 69.58 | 55.69 |
Second Quarter | 63.60 | 55.49 | 68.88 | 57.78 |
Third Quarter | 62.99 | 43.55 | 64.35 | 42.96 |
Fourth Quarter | 52.55 | 40.31 | 53.69 | 40.40 |
Annual | 63.60 | 40.31 | 69.58 | 40.40 |
2003 | | | | |
First Quarter | 46.80 | 34.16 | 44.52 | 31.60 |
Second Quarter | 54.67 | 41,76 | 46.40 | 37.10 |
Third Quarter | 49.50 | 38.88 | 44.00 | 35.22 |
August | 42.27 | 38.88 | 38.10 | 35.22 |
September | 45.82 | 41.70 | 41.09 | 36.77 |
October | 49.13 | 43.40 | 42.09 | 37.00 |
November | 51.65 | 46.58 | 43.45 | 40.10 |
December | 52.60 | 49.54 | 43.16 | 39.86 |
Fourth Quarter | 52.60 | 43.40 | 43.45 | 37.00 |
Annual | 54.67 | 34.16 | 46.40 | 31.60 |
2004 | | | | |
January | 58.50 | 51.00 | 46.30 | 40.23 |
February | 54.20 | 48.53 | 43.21 | 38.40 |
Share Capital
The share capital of Schering AG consists of ordinary shares. All the issued ordinary share capital of Schering AG is in bearer form and is freely transferable. On December 31, 2003, there were 194,000,000 issued and outstanding shares without par value. There are also American Depositary Receipts (ADRs) issued under our sponsored ADR program with JP Morgan Chase Bank. Each ADR evidences an American Depositary Share (ADS) which represents one share. On January 30, 2004, there were 3,316,047 issued and outstanding ADRs.
MARKETS
General
The principal trading market for the shares is the Frankfurt Stock Exchange. The shares are also listed on other German stock exchanges, namely Berlin, Bremen, Dusseldorf, Hamburg, Hanover, Munich and Stuttgart. In addition, the shares are listed on the Zurich stock exchange. Effective as of March 31, 2003, Schering AG has withdrawn the listing of its shares from the London Stock Exchange due to the decline in the trading volume of its shares at this exchange. Options on shares are traded on the German options exchange (Eurex).
ADRs, each representing one share, were listed on the New York Stock Exchange (NYSE) on October 12, 2000 and trade under the symbol "SHR".
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ARTICLES OF ASSOCIATION
Incorporated by reference to Amendment No.1 to the Form F-4 Registration Statement filed with the Securities and Exchange Commission on May 17, 2002.
The share capital has been reduced to €194,000,000 by way of cancellation of 2,500,000 shares that had been previously redeemed under authorization of the Annual General Meeting.
MATERIAL CONTRACTS
Not applicable
EXCHANGE CONTROLS
The euro is a fully convertible currency. There are, except in limited embargo circumstances, no legal restrictions in Germany on international capital movements and foreign exchange transactions. For statistical purposes only, with certain exceptions, every corporation or individual residing in Germany must report to the German Central Bank (Deutsche Bundesbank) any payment received from or made to a non-resident corporation or individual if the payment exceeds €12,500 (or the equivalent in a foreign currency). Additionally, corporations and individuals residing in Germany must report to the German Central Bank any claims of a resident corporation or individual against, or liabilities payable to, a non-resident corporation or individual exceeding an aggregate of €5m (or the equivalent in a foreign currency) at the en d of any calendar month.
Neither German law nor our Articles of Association restrict the right of non-resident or non-German owners to hold or vote the shares.
TAXATION
German Taxation
The following discussion describes the material German tax consequences of owning shares or American Depositary Shares (ADSs). It applies to you if you are a "Non-German Holder". You are a Non-German Holder if you:
This summary is based on German law and tax and other treaties between Germany and other countries as they are in effect as of the date hereof, and is subject to changes in German law or such treaties. This section is not a comprehensive discussion of all of the German tax consequences that may be relevant for Non-German Holders. You should consult your tax advisor regarding the German federal, state and local tax consequences of the purchase, ownership and disposition of shares or ADSs and the procedures for the refund of German taxes withheld from dividends.
Dividends
Under German law, German corporations must withhold tax on dividends in an amount equal to 20% of the gross amount paid to resident and non-resident holders. An applicable tax treaty may reduce the rate of withholding tax on dividend distributions paid to Non-German Holders. Most tax treaties to which Germany is party, including the treaty between Germany and the United States (the "Treaty"), reduce the withholding tax rate to 15%. You would receive this reduction by applying for a refund of the difference between the tax withheld at the statutory rate of 20% and the applicable treaty rate to the German tax authorities, located at the Bundesamt für Finanzen, Friedhofstrasse 1, D-53225 Bonn, Germany. If you are entitled to benefits under the Treaty, a special refund procedure may apply, which we describe below und er the heading " -Dividend refund procedure for U.S. holders".
A surtax on the German withholding tax is currently levied on dividend distributions paid by a German resident company at a rate of 5.5% of the basic 20% withholding tax on dividend distributions. At this rate, the surtax amounts to 1.1% (5.5 x 20%) of the gross amount of the dividend paid by Schering AG. The Treaty entitles qualifying U.S. shareholders to a full refund of this surtax.
As a result, a qualifying U.S. shareholder entitled to a gross dividend of €100 from Schering AG will, after applicable refunds of German withholding tax, receive a cash payment of €85 (€100 gross dividend from Schering AG minus €15 German withholding tax [€21.1 basic withholding tax and surtax on the gross dividend minus applicable Treaty refund of €6.1]).
Dividend Refund Procedure For U.S. Holders
For shares and ADSs that are kept in custody with the Depositary Trust Company in New York or one of its participating banks, the German tax authorities have introduced a collective procedure for the refund of German withholding tax and surtax, on a trial basis. Under this procedure, the Depositary Trust Company may submit claims for refunds payable to U.S. holders as defined below under the heading “ -U.S. Taxation” under the Treaty collectively to the German tax authorities on behalf of these U.S. holders. The German Federal Tax Office (Bundesamt für Finanzen) will pay the refund amounts on a preliminary basis to the Depositary Trust Company, which will redistribute these amounts to you and other U.S. holders according to the regulations governing the procedure. The Federal Tax Office may review whether the ref und conforms with the law within four years after making the payment to the Depositary Trust Company. Details of this collective refund procedure are available from the Depositary Trust Company.
If you are not eligible for the special refund procedure described in the preceding paragraph, you must make an individual claim for refund. Individual claims for refund are made on Form "Claim for refund of German withholding taxes on dividends and/or interest", which you must file with the German authorities at the Bundesamt für Finanzen, Friedhofstrasse 1, D-53225 Bonn, Germany. You can obtain copies of the required form from the German tax authorities at the same address or from the Embassy of the Federal Republic of Germany, 4645 Reservoir Road, N.W., Washington D.C. 20007-1998. The required form can be found on the internet under www.bff-online.de.
As part of the individual refund claim, you must submit to the German tax authorities the original bank voucher (or certified copy thereof) issued by the paying entity documenting the tax withheld, and an official certification on IRS Form 6166 of your last United States Federal income tax return. You can obtain IRS Form 6166 by filing a request with the Internal Revenue Service Center in Philadelphia, Pennsylvania. Foreign Certification Request, P.O. Box 16347, Philadelphia, PA 19114-0447. Requests for certification must include your name, Social Security Number or Employer Identification Number, tax return form number, tax period for which the certification is requested and the country for which certification is needed. You can also request that the Internal Revenue Service send the certification directly to the German tax au thorities. If you do not make such a request, the Internal Revenue Service will send a certificate on IRS Form 6166 to you, and you must submit the certification with its claim for refund.
Capital Gains
Under German domestic tax law, capital gains you derive from the sale or other disposition of shares or ADSs are subject to tax in Germany only if you have held, directly or indirectly, shares or ADSs representing 1% or more of the registered share capital of Schering AG at any time during the five-year period immediately preceding the disposition. Most German tax treaties, including the Treaty, provide that Non-German Holders are not subject to German tax even in that case.
Inheritance And Gift Tax
Under German law, German gift or inheritance tax will be imposed on transfers of shares or ADSs by a gift or on the death of a Non-German Holder only in the following situations:
if you or another transferor, or your heir, donee or other beneficiary, was domiciled in Germany at the time of the transfer or, if you are a German citizen who is not domiciled in Germany, if you, another transferor or your beneficiary has not been continuously outside of Germany for a period of more than 5 years; or
if your shares or ADSs are subject to such a transfer and form part of a portfolio which represents 10% or more of the registered share capital of the company and you have held such shares directly or indirectly yourself or together with a related person.
The few German estate tax treaties currently in force, including the treaty with the United States, usually provide that German gift or inheritance tax may only be imposed in situations falling under the first condition above.
Other Taxes
No German transfer, stamp or other similar taxes apply to your purchase, sale or other disposition of shares or ADSs.
U.S. Taxation
This section describes the material United States Federal income tax consequences of owning shares or ADSs. It applies to you only if you hold your shares or ADSs as capital assets for tax purposes. This section does not address special classes of holders, some of whom may be subject to other rules, including:
tax-exempt entities;
certain insurance companies;
broker-dealers;
traders in securities that elect to mark to market;
investors liable for alternative minimum tax, investors that actually or constructively own 10% or more of the voting stock of Schering AG, investors that hold shares or ADSs as part of a straddle or a hedging or conversion transaction; or
investors whose functional currency is not the U.S. dollar.
This section is based on the tax laws of the United States, including the Internal Revenue Code of 1986, as amended, its legislative history, existing and proposed regulations, and published rulings and court decisions, as currently in effect, as well as on the Treaty. These laws are subject to change, possibly on a retroactive basis.
You are a "U.S. holder" if you are a beneficial owner of shares or ADSs and you are:
a citizen or resident of the United States;
a United States corporation or other entity taxable as a corporation in the United States; or
an estate whose income is subject to United States Federal income tax regardless of its source, or a trust if a United States court can exercise primary supervision over the trust's administration and one or more United States persons are authorized to control all substantial decisions of the trust.
You are an "eligible U.S. holder" if you are a U.S. holder and you are:
a resident of the United States for purposes of the Treaty, do not maintain a permanent establishment or fixed base in Germany to which the shares or ADSs are attributable and through which you carry on or have carried on business or, if you are an individual, perform or have performed independent personal services; and
otherwise eligible for benefits under the Treaty with respect to income and gain from the shares or ADSs.
You are a "non-U.S. holder" if you are a beneficial owner of shares or ADSs and you are not a U.S. holder (as described above).
This discussion addresses only United States Federal income taxation. You should consult your own tax advisor regarding the United States Federal, state, local and other tax consequences of owning and disposing of shares and ADSs in your particular circumstances. In particular, you should confirm your status as an eligible U.S. holder with your advisor and should discuss any possible consequences of failing to qualify as an eligible U.S. holder.
In general, for United States Federal income tax purposes, if you hold ADRs evidencing ADSs, you will be treated as the owner of the shares represented by those ADSs. Exchanges of shares for ADSs, and ADSs for shares, generally will not be subject to United States Federal income tax.
Taxation of Dividends
U.S. Holders
If you are a U.S. holder, you must include in your gross income the gross amount of any dividend including any German tax witheld on the dividend paid by Schering AG out of its current or accumulated earnings and profits, as these amounts are determined for United States Federal income tax purposes.
The dividend is ordinary income that you must include in income when you receive the dividend, actually or constructively. The dividend will not be eligible for the dividends-received deduction generally allowed to United States corporations in respect of dividends received from other United States corporations. Dividends received by individuals from January 1, 2003 through December 31, 2008 will be taxed at a maximum rate of 15%. The application of this reduced rate is subject to certain restrictions, which cannot be described in detail. The amount of the dividend distribution that you must include in your income as a U.S. holder will be the U.S. dollar value of the euro payments made, determined at the spot euro/U.S. dollar rate on the date the dividend distribution is includable in your income, regardless of whether the paym ent is in fact converted into U.S. dollars. Generally, any gain or loss resulting from currency exchange fluctuations during the period from the date you include the dividend payment in income to the date you convert the payment into U.S. dollars will be treated as ordinary income or loss. The gain or loss generally will be income from sources within the United States for foreign tax credit limitation purposes. Distributions in excess of current and accumulated earnings and profits, as determined for United States Federal income tax purposes, will be treated as a return of capital to the extent of your basis in the shares or ADSs and thereafter as capital gain.
Dividends will constitute income from sources outside the United States, but generally will be "passive income" or "financial services income" which are treated separately from other types of income for purposes of computing the foreign tax credit allowable to you.
Subject to certain limitations, you may credit against your United States Federal tax liability the net amount (after applicable refunds) of any German tax withheld in accordance with German law or the Treaty. For United States tax purposes, you generally will be treated as paying German withholding taxes of €15 on every €100 of gross dividend paid by Schering AG (€21.1 basic withholding tax and surtax on the gross dividend minus applicable Treaty refund of €6.1). If you are eligible for the reduced 15% tax rate on dividends, certain adjustments have to be made to the determination of the maximum amount of foreign tax that may be credited against your U.S. Federal tax liability. These adjustments reduce the maximum amount of foreign tax credits, therefore in most cases the German withholding might not be ful ly credited against your U.S. Federal tax liability. The impact of the effective tax rate on dividends resulting from the dividend rate deduction together with the adjustment to the foreign tax credit limitations depends on each individual’s tax situation. If you cannot or choose not to use the German withholding tax as a credit, you may generally treat that tax as an itemized deduction for United States Federal income tax purposes.
Non-U.S. Holders
If you are a non-U.S. holder, dividends paid to you in respect of shares or ADSs will not be subject to United States Federal income tax unless effectively connected with your conduct of a trade or business within the United States. The dividends must also be attributable to a permanent establishment that you maintain in the United States, if that is required by an applicable income tax treaty as a condition for subjecting you to United States taxation on a net profit basis. In such cases you will be taxed in the same manner as a U.S. holder. If you are a corporate non-U.S. holder, effectively connected dividends may, under certain circumstances, be subject to an additional branch profits tax at a 30% rate or at a lower rate if you are eligible for the benefits of an income tax treaty that provides for a lower rate.
Taxation Of Capital Gains
U.S. Holders
If you are a U.S. holder and sell or otherwise dispose of your shares or ADSs, you will recognize capital gain or loss for United States Federal income tax purposes equal to the difference between the U.S. dollar value of the amount that you realize and your tax basis, determined in U.S. dollars, in your shares or ADSs. Capital gain of a non-corporate U.S. holder is generally taxed at a maximum rate of 15% from January 1, through December 31, 2008, for property held more than one year. Additionally, gain or loss will generally be income from sources within the United States for foreign tax credit limitation purposes.
Non-U.S. Holders
If you are a non-U.S. holder, you will not be subject to United States Federal income tax on gain recognized on the sale or other disposition of your shares or ADSs unless:
the gain is effectively connected with your conduct of a trade or business in the United States; the gain must also be attributable to a permanent establishment that you maintain in the United States, if that is required by an applicable income tax treaty as a condition for subjecting you to United States taxation on a net profit basis; or
you are an individual, you are present in the United States for 183 or more days in the taxable year of the sale and certain other conditions exist.
If you are a corporate non-U.S. holder, effectively connected gains that you recognize may also, under certain circumstances, be subject to an additional branch profits tax at a 30% rate or at a lower rate if you are eligible for the benefits of an income tax treaty that provides for a lower rate.
Backup Withholding And Information Reporting
In general, dividend payments, or other taxable distributions, made within the United States to you will be subject to information reporting requirements and backup withholding tax at a rate that is currently 28% if you are a non-corporate United States person and, you:
fail to provide an accurate taxpayer identification number;
are notified by the Internal Revenue Service that you have failed to report all interest or dividends required to be shown on your Federal income tax returns; or
in certain circumstances, fail to comply with applicable certification requirements.
Certain corporations and persons that are not United States persons may be required to establish their exemption from information reporting and backup withholding by certifying their status on Internal Revenue Service Forms W-8BEN, W-8ECI or W-9.
If you sell your shares or ADSs to or through a United States office of a broker, the payment of the proceeds is subject to both United States backup withholding and information reporting unless you certify that you are a non-U.S. person, under penalties of perjury, or you otherwise establish an exemption. If you sell your shares or ADSs through a non-U.S. office of a non-U.S. broker and the sale proceeds are paid to you outside the United States then information reporting and backup withholding generally will not apply to that payment. However, United States information reporting requirements, but not backup withholding, will apply to a payment of sales proceeds, even if that payment is made to you outside the United States, if you sell your shares or ADSs through a non-U.S. office of a broker that is a U.S. person or has cert ain other contacts with the United States.
You generally may obtain a refund of any amounts withheld under the backup withholding rules that exceed your income tax liability by filing a refund claim with the United States Internal Revenue Service.
DOCUMENTS ON DISPLAY
Schering AG is subject to the informational reporting requirements of the Securities Exchange Act of 1934 and files reports and other information with the Securities and Exchange Commission. You may examine the reports and other information filed by Schering AG at the public reference facilities maintained by the SEC at Room 1024, 450 Fifth Street, N.W., Washington, D.C., 20549. You may also receive copies of these materials by mail from the SEC's Public Reference Branch at 450 Fifth Street, N.W., Washington, D.C., 20549. For more information on the public reference room, call the SEC at 1-800-SEC-0330. Our reports and other information filed with the SEC are also available to the public from commercial document retrieval services and the website maintained by the SEC at http://www.sec.gov. The ADRs are traded on the New York Stock Exchange, and the materials filed by us are available for inspection and copying at their offices at 20 Broad Street, New York, New York, 10005.
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Due to our global business and existing current assets, we are exposed to various market risks (i.e., the risk of loss arising from adverse changes in market rates and prices). Our principal market risks are:
foreign exchange-rates, generating translation and transaction gains and losses.
interest rate and other risks related to financial assets and liabilities.
equity price risks relating to the equity securities we hold of certain of our collaboration partners.
Our central treasury function located at Schering AG's headquarters is responsible for market risk management. The Schering AG central treasury enters into virtually all derivatives contracts utilized by the Group. Derivative instruments are used only for non-trading purposes such as hedging. Subsidiaries are permitted to enter into derivative contracts only in exceptional situations after obtaining the prior consent of Schering AG central treasury.
Risk management transactions are executed within the common framework of limits, segregation of duties, and position and result reporting by an experienced staff with selected banks with a minimum long-term rating of "A-". The positions are valued mark-to-market on a regular (mainly daily) basis.
The risks involved with cash and derivative positions in foreign exchange and asset- liability risk management are measured and limited with an in-house risk management system based on historical simulation. The simulation system calculates the worst case results for given single positions and whole portfolios within the last ten years. The time bracket to calculate the worst case adverse market movements can be flexibly determined and is normally set to one-month and one-year periods.
FOREIGN EXCHANGE RISK MANAGEMENT
Approximately 56% of our net sales in 2003 were made in currencies other than the euro, including the U.S. dollar, the Japanese yen, the British pound sterling and the Brazilian real. See "Item 5-Operating and Financial Review and Prospects-Liquidity and Capital Resources- Foreign Currency" for information on the range of currencies in which we made sales in 2001, 2002 and 2003. We therefore face considerable foreign exchange risks regarding our balance-sheet exposure (current assets minus current liabilities in foreign currencies) and our future anticipated exposure (future sales minus future costs in non-euro currencies). In accordance with our risk management policy, balance-sheet exposure is fully hedged and our future anticipated exposure for a rolling twelve-month period is in general 50% hedged. The hedge level of our anticipated exposure may be varied between 0% and 100% of this anticipated exposure in accordance with our market expectations. As of December 31, 2003, the maximum term of our foreign exchange contracts was less than six months.
Hedges for Balance-Sheet Exposure
The following table sets forth, as of December 31, 2003, information about foreign currency forward exchange contracts entered into to hedge our balance-sheet exposure:
Foreign currency forward exchange agreements |
---|
| | Exchange rate | Contract amount buy (sell) | Fair value |
---|
Currency pairs | | | (€million) |
---|
| | | | |
British pound | euro | 0.7027 | (7.8) | 0.0 |
| | | | |
Canadian dollar | euro | 1.5906 | 3.4 | (0.1) |
Czech krona | Euro | 32.14 | (2.6) | 0.0 |
Euro | South Korean won | 1397.6 | 0.5 | 0.0 |
| | | | |
Japanese yen | euro | 132.05 | (170.3) | 3.9 |
Mexican peso | euro | 13.96 | (11.3) | 0.2 |
Polish zloty | euro | 4.6730 | (8.5) | 0.1 |
South African rand | euro | 7.8753 | (9.3) | 0.5 |
Swedish krona | euro | 8.9345 | (2.1) | 0.0 |
| | | | |
Swiss franc | euro | 1.5425 | (10.1) | 0.1 |
Thailand bath | euro | 47.76 | (6.0) | 0.3 |
U.S. dollar | euro | 1.2386 | 21.0 | (0.4) |
U.S. dollar | euro | 1.2383 | (9.0) | 0.2 |
U.S. dollar | Indonesian rupiah | 1213.8 | 4.5 | (0.1) |
U.S. dollar | South Korean won | 8720.0 | 2.5 | (0.1) |
Hedges for Anticipated Exposure
The following table sets forth, as of December 31, 2003, information about foreign currency forward exchange contracts entered into to hedge our anticipated exposure:
Foreign currency forward exchange agreements |
---|
| | Exchange rate | Contract amount buy (sell) | Fair value |
---|
Currency pairs | | | (€million) |
---|
Australian dollar | euro | 1.6576 | (28.0) | 0.4 |
British pound | euro | 0.7027 | (56.0) | 0.2 |
Canadian dollar | euro | 1.5906 | (8.3) | 0.2 |
| | | | |
Czech krona | euro | 32.14 | (11.6) | 0.1 |
Hungarian forint | euro | 274.50 | 2.9 | 0.1 |
Hungarian forint | euro | 274.50 | (5.7) | (0.2) |
Japanese yen | euro | 132.46 | 24.1 | -0.5 |
Japanese yen | euro | 131.80 | (78.5) | 1.9 |
Mexican peso | euro | 13.96 | (24.5) | 0.4 |
Polish zloty | euro | 4.6774 | (16.9) | 0.1 |
South African rand | euro | 7.8950 | (11.2) | 0.6 |
| | | | |
Swedish krona | euro | 8.9345 | (22.6) | 0.4 |
Swiss franc | euro | 1.5425 | (18.3) | 0.2 |
| | | | |
Thailand bath | euro | 47.76 | (4.8) | 0.2 |
U.S. dollar | euro | 1.2296 | (211.1) | 5.7 |
| | | | |
Foreign currency option contracts |
---|
| Option type | Strike price | Contract amount | Fair value |
---|
U.S. dollar/euro | long put | 1.2000 | 15.9 | 0.8 |
U.S. dollar/euro | short put | 1.2000 | 15.9 | (0.4) |
2003 Compared to 2002
The foreign currency hedge for our balance-sheet exposure decreased from a total nominal amount €362m as of December 31, 2002 to €251m as of December 31, 2003. The primary reasons for this decrease were changes in intercompany loan levels and the higher value of the euro.
The foreign currency hedge for our anticipated exposure decreased from €594m as of December 31, 2002 to €479m as of December 31, 2003 mainly due to lower exposures and the higher value of the euro.
ASSET-LIABILITY RISK MANAGEMENT
Asset-Liability Risk Management encompasses the interest rate and other risks related to financial assets and liabilities. As of December 31, 2003, our cash and securities classified as current assets amounted to €739m. Our short-term cash deposits are mainly euro denominated. Our total bank liabilities as of December 31, 2003 amounted to €110m. These liabilities are mostly short-term liabilities and are principally denominated in the local currencies of the group companies.
As of December 31, 2003, our positive net cash position (which we define as marketable securities and cash and cash equivalents less bank loans and overdrafts) was €629m. The portfolio is diversified in a range of cash assets which are supplemented by derivative instruments in order to generate the intended asset profile for the whole portfolio. Apart from risk limits, the short- term and mid-term liquidity requirements of the Group are also taken into account in the management of the maturity profile of cash assets. As is discussed under "-Foreign Exchange Risk Management", currency risk caused by cash and derivative positions of Asset-Liability Risk Management is hedged as a balance-sheet exposure.
The following tables set forth the nominal and fair values, maturity and contract terms of the interest rate sensitive financial instruments that were held by the Group as of December 31, 2003.
Assets and liabilities |
---|
| 2004 | 2005 | 2006 | 2007 | 2008 | There- after | Total | Fair value |
---|
Euro: | (€million) |
---|
Fixed income | | | | | | | | |
Cash/Deposits | 463 | | | | | | 463 | 463 |
Average yield (%) | 2.1% | | | | | | 2.1% | |
Fixed income securities | | | | | | 2 | 2 | 2 |
Average yield (%) | | | | | | 4.0% | 4.0% | |
Liabilities | (69) | | | | (1) | | (70) | (70) |
Average yield (%) | 4.6% | | | | 9.0% | | 4.6% | |
Other: | | | | | | | | |
Equity securities (mainly €) | | | | | | | 10 | 10 |
U.S. dollar | | | | | | | | |
Fixed income | | | | | | | | |
Cash/Deposits | 28 | | | | | | 28 | 28 |
Average yield (%) | 1.1% | | | | | | 1.1% | |
Fixed income securities* | | | | | | 155 | 155 | 155 |
Average yield | | | | | | 3.6% | 3.6% | |
Liabilities | (10) | (3) | | | | | (13) | (13) |
Average yield (%) | 1.1% | 2.5% | | | | | 1.4% | |
Other currencies: | | | | | | | | |
Fixed income | | | | | | | | |
Cash/deposits | 81 | | | | | | 81 | 81 |
Liabilities | (27) | | | | | | (27) | (27) |
*invested in Mutual Bond Funds |
Derivative positions |
---|
| 2004 | 2005 | 2006 | 2007 | 2008 | There- after | Total | Fair Value |
---|
Euro: | (€million) |
---|
Fixed income | | | | | | | | |
German Bund Futures | | | | | | 7 | 7 | 0 |
Yield (%) | | | | | | 4.2% | 4.2% | |
German Bobl Futures | | | | | 38 | | 38 | 0 |
Yield (%) | | | | | 3.5% | | 3.5% | |
Japanese yen: | | | | | | | | |
Japanese government bond futures | | | | | | 19 | 19 | 0 |
Yield (%) | | | | | | 1.4% | 1.4% | |
Other derivatives: | | | | | | | | |
Euro: | | | | | | | | |
Long call options on Schering AG shares | | 10 | 10 | 22 | 22 | 19 | 83 | 14 |
U.S. Dollar: | | | | | | | | |
Long equity swap on S&P 500 | | 7 | | | | | | 2 |
2003 Compared to 2002
Our net cash position as described above increased by €63m to €629m at December 31, 2003 from €566m at December 31, 2002.
EQUITY PRICE RISK IN RESEARCH COLLABORATION PARTNERS
As part of our research and development activities, we from time to time enter into research collaboration efforts with various companies in the pharmaceutical sector. In connection with these research collaboration efforts, we acquire equity investments in our collaboration partners from time to time. In most cases, the transfer and sale of these equity investments are subject to contractual and regulatory restrictions. Equity investments subject to such restrictions are shown in the Balance Sheet in our Consolidated Financial Statements under "Financial assets/ Other Investments". The book value of these equity investments (of which only some are publicly traded securities) amounted to approximately €18m as of December 31, 2003. The market value of certain of these equity investments can fluctuate significantly . We do not have any derivative financial instruments to mitigate the fluctuation in the value of the investments. In 2003, we have recognized impairment charges of €8m for these equity investments.
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Not applicable.
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As of December 31, 2003 (the "Evaluation Date"), Schering Aktiengesellschaft (the "Company") conducted an evaluation (under the supervision and with the participation of the Company's management, including the Chief Executive Officer and Chief Financial Officer), pursuant to Rule 13a-15 promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), of the effectiveness of the design and operation of the Company's disclosure controls and procedures. Based on this evaluation, the Company's Chief Executive Officer and Chief Financial Officer concluded that as of the Evaluation Date such disclosure controls and procedures were reasonably designed to ensure that information required to be disclosed by the Company in reports it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission.
Since December 31, 2003, there have not been any significant changes in the internal control or in other factors that could significantly affect the internal controls.
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The Supervisory Board has determined that Dr. Karl-Hermann Baumann, chairman of the Audit Committee, qualifies as Audit Committee Financial Expert in accordance with the terms of Item 16.A of Form 20-F. See “Item 6-Directors, Senior Management and Employees-Board Practices”.
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We have adopted a written code of ethics that applies to, among others, the principal executive officer, principal financial officer and principal accounting officer of Schering Aktiengesellschaft. The code of ethics is filed as an exhibit to this Form 20-F Annual Report.
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BDO has served as Schering AG Group’s principal independent auditor for each of the fiscal years in the three-year period ended December 31, 2003. Fees billed by BDO for professional services in each of the last two fiscal years were as follows:
| Year ended December 31, |
---|
| 2003 | | 2002 | |
---|
| € | | € | |
---|
| (in millions) |
---|
Audit fees | 3.5 | | 3.4 | |
Audit-related fees | 0.1 | | 0.0 | |
Tax fees | 0.3 | | 0.2 | |
All other fees | 0.0 | | 0.1 | |
Total | 3.9 | | 3.7 | |
“Audit Fees” are the aggregate fees billed by BDO for professional services in connection with the audit of the Company’s consolidated annual financial statements, reviews of interim financial statements, as well as audits of statutory financial statements of Schering AG and its affiliates. Also included in “Audit Fees” are amounts billed for attestation services in relation to regulatory filings and other compliance requirements.
“Audit-Related Fees” are fees billed by BDO for attestation regarding compliance with certain agreements, the audit of employee benefit plans and pension schemes, and other agreed-upon procedures.
“Tax Fees” comprise fees for tax declarations, advice on actual or contemplated transactions, and expatriate employee tax services.
Subsequent to the auditor’s appointment, the Audit Committee awards the contract and in its sole authority approves the terms and scope of the audit and monitors the auditors’ independence. In order to assure the independence of the auditors, the Audit Committee established a policy of ongoing supervision and pre-approval of permissible audit-related and tax services provided by the independent auditors. According to this policy, permissible audit-related and tax services are pre-approved under the provision that the accumulated fees for such services do not exceed 5% of the total fees and the Audit Committee is notified of such services before they are completed. All other services require pre-approval on a case-by-case basis.
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Schering AG is furnishing financial statements pursuant to the instructions of Item 18 of Form 20-F.
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See our Consolidated Financial Statements beginning at F-1.
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1.1 | Articles of Association (Satzung) of Schering Aktiengesellschaft, as amended to date (English-language convenience translation thereof) |
2.1 | Form of Deposit Agreement among Schering Aktiengesellschaft, JP Morgan Chase Bank, as depositary, and the holders from time to time of American Depositary Receipts* |
2.2 | Form of American Depositary Receipt (included in Exhibit 2.1) |
2.3 | Long-term debt instruments. Schering Aktiengesellschaft undertakes to provide the Securities and Exchange Commission with copies upon request |
4.1 | Summary of Employment Arrangements between Schering AG and Dr. Hubertus Erlen** |
8.1 | Subsidiaries of Schering Aktiengesellschaft |
11.1 | Code of Ethics of Schering Aktiengesellschaft |
12.1 | Certification of Principal Executive Officer pursuant to Rule 13a-14(a) promulgated under the U.S. Securities Exchange Act of 1934 |
12.2 | Certification of Principal Financial Officer pursuant to Rule 13a-14(a) promulgated under the U.S. Securities Exchange Act of 1934 |
13.1 | Certification pursuant to 18 U.S.C. Section 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |
* Incorporated by reference to Form 20-F Registration Statement of Schering Aktiengesellschaft filed with the Securities and Exchange Commission on September 27, 2000 ** Incorporated by reference to Form 20-F annual report of Schering AG filed with the Securities and Exchange Commission on March 13, 2002
|
SIGNATURES
Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the registrant certifies that it meets all of the requirements for filing on Form 20-F and has duly caused this annual report to be signed on its behalf by the undersigned, thereunto duly authorized.
Schering AKTIENGESELLSCHAFT
By: /s/ JÖRG SPIEKERKÖTTER
Name: Dr. Jörg Spiekerkötter
Title: Chief Financial Officer
Date: March 8, 2004
Schering AG
Index to Consolidated Financial Statements
Report of Independent Auditors | |
Consolidated Financial Statements: | |
Consolidated Income Statements for the years ended December 31, 2003, 2002 and 2001 | |
Consolidated Balance Sheets as of December 31, 2003 and 2002 | |
Consolidated Cash Flow Statements for the years ended December 31, 2003, 2002 and 2001 | |
Consolidated Statements of Changes in Shareholders' Equity for the years ended December 31, 2003, 2002 and 2001 | |
Notes to the Consolidated Financial Statements | |
Report of Independent Auditors
We have audited the consolidated balance sheets of Schering Aktiengesellschaft (Schering AG) as of December 31, 2003 and 2002, and the consolidated statements of income, cash flows and changes in shareholders‘ equity for each of the years in the three-year period ending December 31, 2003. The preparation and the content of these consolidated financial statements are the responsibility of the Company’s Executive Board. Our responsibility is to express an opinion on whether these consolidated financial statements comply with International Financial Reporting Standards (IFRS), based on our audit.
We conducted our audit in accordance with the International Standards on Auditing issued by the International Federation of Accountants (IFAC) and auditing standards generally accepted in the United States (U.S. GAAS). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatements.
An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the consolidated financial statements. An audit also includes assessing accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.
In our opinion, the consolidated financial statements present in accordance with IFRS fairly the net assets and financial position as of December 31, 2003 and 2002 and the results of operations and cash flows for each of the years in the three-year period ended December 31, 2003.
Application of accounting principles generally accepted in the United States (U.S. GAAP) would have affected shareholders‘ equity as of December 31, 2003, 2002 and 2001 and net profit for each of the years in the three-year period ended December 31, 2003 to the extent summarized in Notes (37) and (38) to the consolidated financial statements.
Berlin, Germany
February 25, 2004
BDO Deutsche Warentreuhand Aktiengesellschaft Wirtschaftsprüfungsgesellschaft | |
Schering AG
CONSOLIDATED INCOME STATEMENTS
Consolidated Income Statements for the Years Ended December 31, 2003, 2002 and 2001
(in Millions Except per Share Data)
| See Notes | 2003 | 2003 | 2002 | 2001 |
---|
| | $(1) | € | € | € |
---|
Net sales | | 6,082 | 4,828 | 5,023 | 4,842 |
Cost of sales | | (1,553) | (1,233) | (1,212) | (1,215) |
Gross profit | | 4,529 | 3,595 | 3,811 | 3,627 |
Marketing and selling costs | | (1,921) | (1,525) | (1,629) | (1,601) |
Engineering and administration costs | (6) | (713) | (566) | (566) | (525) |
Research and development costs | | (1,164) | (924) | (947) | (864) |
Other operating income | (7) | 502 | 399 | 370 | 348 |
Other operating expenses | (8) | (369) | (293) | (298) | (317) |
Operating profit | | 864 | 686 | 741 | 668 |
Financial result | (9) | 19 | 15 | (23) | 30 |
Income from disposal of Aventis CropScience | (10) | — | — | 689 | — |
Acquisition-related expenses | (11) | — | — | (262) | — |
Profit from ordinary activities | | 883 | 701 | 1,145 | 698 |
Income taxes | (12) | (321) | (255) | (276) | (270) |
Net profit before minority interest | | 562 | 446 | 869 | 428 |
Minority interest | | (4) | (3) | (2) | (10) |
Net profit | | 558 | 443 | 867 | 418 |
EARNINGS PER SHARE (basic) | (13) | 2.87 | 2.28 | 4.39 | 2.11 |
EARNINGS PER SHARE (diluted) (2) | (13) | 2.87 | 2.28 | 4.38 | 2.10 |
(1) The 2003 figures have been translated solely for the convenience of the reader at an exchange rate of $1.2597 to €1.00, the noon buying rate on December 31, 2003. (2) Diluted by stock options issued as part of Long Term Incentive Plans
|
The accompanying Notes are an integral part of these Consolidated Financial Statements.
Schering AG
CONSOLIDATED BALANCE SHEETS
Consolidated Balance Sheets as of December 31, 2003 and 2002
| See Notes | 2003 | 2003 | 2002 |
---|
| | $ million(1) | € million | € million |
---|
ASSETS | | | | |
Intangible assets | (15) | 911 | 723 | 846 |
Property, plant and equipment | (16) | 1,528 | 1,213 | 1,230 |
Financial assets | (17) | 112 | 89 | 120 |
Fixed assets | | 2,551 | 2,025 | 2,196 |
Inventories | (18) | 1,254 | 996 | 971 |
Trade receivables | (19) | 1,371 | 1,088 | 1,054 |
Other receivables and other assets | (20) | 682 | 541 | 514 |
Marketable securities | (21) | 218 | 173 | 249 |
Cash and cash equivalents | | 713 | 566 | 408 |
Other non-current and current assets | | 4,238 | 3,364 | 3,196 |
TOTAL ASSETS | | 6,789 | 5,389 | 5,392 |
SHAREHOLDERS' EQUITY AND LIABILITIES | | | | |
Issued capital(2) | | 244 | 194 | 197 |
Share premium account | | 421 | 334 | 331 |
Paid-up capital | (22) | 665 | 528 | 528 |
Retained earnings | (23) | 2,991 | 2,374 | 2,406 |
Shareholders' equity | | 3,656 | 2,902 | 2,934 |
Minority interest | | 20 | 16 | 15 |
Provisions for pensions and similar obligations | (24) | 726 | 576 | 560 |
Other provisions | (25) | 1,442 | 1,145 | 1,162 |
Provisions | | 2,168 | 1,721 | 1,722 |
Bank loans and overdrafts | | 139 | 110 | 91 |
Other liabilities | | 806 | 640 | 630 |
Liabilities | (26) | 945 | 750 | 721 |
TOTAL SHAREHOLDERS' EQUITY AND LIABILITIES | | 6,789 | 5,389 | 5,392 |
(1) The 2003 figures have been translated solely for the convenience of the reader at an exchange rate of $ 1.2597 to €1.00, the noon buying rate on December 31, 2003. (2) Contingent capital: €17 m |
The accompanying Notes are an integral part of these Consolidated Financial Statements.
Schering AG
CONSOLIDATED CASH FLOW STATEMENTS
Consolidated Cash Flow Statements for the years ended December 31, 2003, 2002 and 2001
| See Notes | 2003 | 2003 | 2002 | 2001 |
---|
| | $ million(1) | € million | € million | € million |
---|
Net profit before minority interest | | 562 | 446 | 869 | 428 |
Depreciation of fixed assets | | 393 | 312 | 318 | 286 |
Increase in long-term provisions | | 30 | 24 | 29 | 61 |
Other non-cash expenses and income | | 33 | 26 | (40) | (109) |
Result from disposal of fixed assets | | (53) | (42) | (651) | (13) |
Purchase of Leukine® development project | | — | — | 224 | — |
Cash flows before working capital changes | | 965 | 766 | 749 | 653 |
Change in inventories and receivables | | (322) | (256) | (251) | (72) |
Change in liabilities and provisions (other than long-term) | | 89 | 71 | 86 | 89 |
Cash flows from operating activities | (29) | 732 | 581 | 584 | 670 |
Purchase of fixed assets | | (400) | (318) | (559) | (388) |
Proceeds from disposal of fixed assets | | 155 | 123 | 1,601 | 42 |
Purchase and sale of marketable securities | | 45 | 36 | (165) | 300 |
Purchase of Leukine® development project | | — | — | (224) | — |
Acquisitions net of cash acquired | | (3) | (2) | 8 | (171) |
Proceeds from disposal of subsidiaries net of cash disposed | | — | — | 24 | — |
Cash flows used in/from investing activities | (30) | (203) | (161) | 685 | (217) |
Dividend payment of Schering AG | | (227) | (180) | (164) | (198) |
Change in financial liabilities | | 29 | 23 | (133) | (37) |
Funding of Schering Pension Trust | | — | — | (500) | (300) |
Purchase of treasury shares | | (113) | (90) | (234) | — |
Cash flows used in financing activities | | (311) | (247) | (1,031) | (535) |
Net change in cash and cash equivalents | | 218 | 173 | 238 | (82) |
Effect of exchange rate movements on cash and cash equivalents | | (19) | (15) | (22) | 0 |
Cash and cash equivalents as of January 1 | | 514 | 408 | 192 | 274 |
Cash and cash equivalents as of December 31 | (28) | 713 | 566 | 408 | 192 |
(1) The 2003 figures have been translated solely for the convenience of the reader at an exchange rate of $ 1.2597 to € 1.00, the noon buying rate on December 31, 2003. |
The accompanying Notes are an integral part of these Consolidated Financial Statements.
Schering AG
CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY
Consolidated Statements of Changes in Shareholders' Equity for the Years Ended December 31, 2003, 2002 and 2001
| Paid-up capital
| Retained earnings | Shareholders’ equity |
---|
| | | Accumulated other comprehensive income | |
---|
| Issued capital | Share premium account | Other retained earnings | Currency translation adjustment | Derivative hedging instruments | Available for-sale securities | |
---|
| € million |
---|
January 1, 2001 | 198 | 330 | 1,675 | 94 | — | — | 2,297 |
First-time application of IFRS 39 | — | — | — | — | 7 | 89 | 96 |
Changes in fair value | — | — | — | — | (2) | (59) | (61) |
Realized gains/losses | — | — | — | — | (1) | (2) | (3) |
Translation adjustments | — | — | — | 7 | — | — | 7 |
Other comprehensive income | — | — | — | 7 | 4 | 28 | 39 |
Net profit | — | — | 418 | — | — | — | 418 |
Dividend payment of Schering AG | — | — | (198) | — | — | — | (198) |
December 31, 2001 | 198 | 330 | 1,895 | 101 | 4 | 28 | 2,556 |
Changes in fair value | — | — | — | — | 41 | (45) | (4) |
Realized gains/losses | — | — | — | — | (21) | 21 | 0 |
Translation adjustments | — | — | — | (234) | — | (1) | (235) |
Other comprehensive income | — | — | — | (234) | 20 | (25) | (239) |
Net profit | — | — | 867 | — | — | — | 867 |
Dividend payment of Schering AG | — | — | (164) | — | — | — | (164) |
Purchase of treasury shares for acquisitions | — | — | (158) | — | — | — | (158) |
Issue of treasury shares for acquisitions | — | — | 148 | — | — | — | 148 |
Purchase of treasury shares (redeemed) | (1) | 1 | (76) | — | — | — | (76) |
December 31, 2002 | 197 | 331 | 2,512 | (133) | 24 | 3 | 2,934 |
Changes in fair value | — | — | — | — | 31 | 5 | 36 |
Realized gains/losses | — | — | — | — | (40) | (7) | (47) |
Translation adjustments | — | — | — | (194) | — | 0 | (194) |
Other comprehensive income | — | — | — | (194) | (9) | (2) | (205) |
Net profit | — | — | 443 | — | — | — | 443 |
Dividend payment of Schering AG | — | — | (180) | — | — | — | (180) |
Purchase of treasury shares (redeemed) | (3) | 3 | (90) | — | — | — | (90) |
December 31, 2003 | 194 | 334 | 2,685 | (327) | 15 | 1 | 2,902 |
The accompanying Notes are an integral part of these Consolidated Financial Statements.
Schering AG
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
A. BASIS OF PRESENTATION
(1) General principles
The consolidated financial statements of Schering Aktiengesellschaft (Schering AG) have been prepared in accordance with International Financial Reporting Standards (IFRS) issued by the International Accounting Standards Board (IASB). New standards issued by the IASB are adopted at the effective date.
Material departures from the German Commercial Code result from fair value accounting for financial instruments, from the recognition of internally developed software, and from the transfer of plan assets and pension obligations into a pension trust.
(2) Companies included in the consolidated financial statements
In addition to Schering AG, the consolidated financial statements include all companies in which Schering AG controls a majority of the members' voting rights (collectively the Schering AG Group or the Group).
31 domestic companies and 112 foreign companies are consolidated. A total of four companies were consolidated for the first time in 2003. Four companies are no longer consolidated. Comparability with previous years is not affected by these changes.
Joint ventures are proportionately consolidated. Associates - investments where we have the ability to exercise significant influence - are accounted for using the equity method.
The principal companies included in the consolidated financial statements are listed in Note (34). The complete list of Group ownership interests is filed with the Commercial Register of the Amtsgericht Charlottenburg (Charlottenburg Local Court), Berlin.
(3) Consolidation principles
Investments in subsidiaries are consolidated by eliminating the Group's acquisition costs against its share of the subsidiaries’ equity at the date of acquisition or first-time consolidation. Any resulting difference between the fair value and the carrying amount is allocated to identifiable assets and liabilities. Any excess of acquisition cost over the fair value of net assets acquired is recognized as goodwill. After deducting the fair value of intangible assets acquired, any excess of the fair value of net assets acquired over acquisition cost is recognized as negative goodwill and deducted from goodwill. Differences contained in the carrying amounts of investments in joint ventures and associates are calculated using the same principles; where appropriate, the financial statements of joint ventures and associates are adjusted to the uniform Group accounting policies set out below.
Intercompany profits and losses, sales, income and expenses, and receivables and liabilities between consolidated companies are eliminated. Intercompany profits relating to joint ventures and associates are also eliminated in proportion to our ownership interest.
(4) Accounting policies
Intangible assets
Goodwill is recognized as an asset and amortized on a straight-line basis over periods of up to 15 years. To determine the useful life of goodwill, the Group takes into consideration contractual obligations, the period in which synergies are expected to be realized, and the strategic importance of the acquisition. Amortization of goodwill is included in Other operating expenses. Negative goodwill arising from acquisitions is recognized as income on a systematic basis under Other operating income over the remaining weighted average useful life of the acquired depreciable/amortizable assets. Other intangible assets are measured at cost (internally developed software at the cost of conversion), less accumulated straight-line amortization. Other intangible assets generally have a useful life of 4 to 8 years unless a different period is indicated (e.g. p eriods based on the life of a patent). Amortization of intangible assets other than goodwill is allocated to the expenses of the appropriate consuming functions.
Property, plant and equipment
Property, plant and equipment are carried at cost less accumulated depreciation for normal wear and tear. In addition to direct costs, the cost of conversion of internally manufactured assets includes proportionate production overheads and depreciation. Grants by third parties reduce the cost of acquisition or conversion. Interest on third-party borrowings is not included in production costs. Repair costs are expensed as incurred. Obligations to restore a previous condition are included in the cost of acquisition or conversion and at the same time recognized as provision. Buildings are depreciated on a straight-line basis over a useful life of no more than 40 years. Machinery and technical equipment are generally depreciated over a useful life of 3 to 20 years, and factory, office and other equipment over a useful life of 3 to 10 years using the straight-line method. Movable assets used for the production of active substances and intermediate products are reduced by diminishing balance depreciation due to the specialized nature of equipment and associated business risks. Fully depreciated assets are retained in property, plant and equipment, and accumulated depreciation accounts, until they are removed from service. In the case of disposals, assets and related depreciation are removed from the accounts and the net amount, less proceeds from disposal, is charged to the income statement under Other operating income and expenses.
Impairment of intangible assets and property, plant and equipment
If the carrying amount of an intangible asset or an item of property, plant and equipment calculated in accordance with these policies exceeds the recoverable amount at the reporting date, the carrying amount is reduced to the recoverable amount. The recoverable amount is measured as the higher of net selling price and value in use determined by the present value of estimated future cash flows. Impairment reviews are made every year for assets or groups of assets affected by events and circumstances which warrant such a review. If the reasons for the impairment loss no longer apply, it is reversed to income.
Financial assets
Investments and long-term securities are recognized at their fair values. Unrealized gains and losses resulting from changes in fair value are recognized net of deferred taxes directly in a separate account in equity. Changes in fair value are recognized in income if the financial asset is disposed of or is determined to be impaired. Investments in associates are accounted for using the equity method, and are therefore carried at cost plus or minus goodwill amortization, profit distributions, and our share of the retained profits or losses of the company concerned. Our share of Other comprehensive income is recognized proportionately. Loans are measured at amortized cost; interest-free and low-interest loans are recognized at their net present value.
Inventories
Inventories are recognized at the lower of cost, which is determined using the weighted average cost method, or net realizable value. The costs of conversion include direct costs, factory overheads and depreciation. The allocation of fixed production overheads to the cost of inventories is based on the normal capacity of the production facilities. Impairment losses are recognized where the cost of inventories exceeds the expected net proceeds from disposal. In addition, the Cost of sales reported in the income statement includes expenses relating to unutilized capacity.
Accounts receivable and bills of exchange
Accounts receivable and bills of exchange are recognized net of an allowance for doubtful accounts.
Marketable securities
Marketable securities are measured using the same principles applicable to the measurement of long-term securities.
Provisions for defined benefit pension plans
Provisions for defined benefit pension plans are calculated using the projected unit credit method and reflect future increases in salaries and pensions. The current service cost arises from the change in the provision for projected benefits. Actuarial gains and losses are deferred and recognized over the expected remaining service period of the employees participating in those plans, to the extent to which such gains and losses exceed 10% of the obligation.
The following assumptions were used in calculating the pension liabilities:
| German plans | Other plans(1) |
---|
| 2003 | 2002 | 2001 | 2003 | 2002 | 2001 |
---|
Discount rate | 5.5% | 5.75% | 6.0% | 4.5% | 5.0% | 5.0% |
Increase in salaries | 2.5% | 3.0% | 3.0% | 3.7% | 4.1% | 4.1% |
Increase in pensions | 1.25% | 1.25% | 1.5% | 0.8% | 0.7% | 0.7% |
Expected return on plan assets | 7.0% | 7.0% | 7.0% | 5.4% | 5.75% | 6.2% |
(1) weighted average of the individual plans |
The defined benefit obligation for German plans is based on Prof. Dr. Klaus Heubeck's 1998 mortality tables.
Assumptions for defined benefit pension plans outside Germany are based on the respective local conditions.
The provision for pensions is determined by calculating the net of the projected benefit obligation and the fair value of plan assets ("funded status"), less unrecognized actuarial gains/losses.
Other provisions
Other provisions are recognized when it is probable that a liability has been incurred and the amount can be reliably estimated. Long-term provisions are reported at their discounted value.
Derivative financial instruments
Derivative financial instruments are measured at fair value. Deferred gains and losses resulting from the hedging of anticipated sales and expenses are recognized directly in Other comprehensive income. The results are only recognized in the income statement after the hedged underlying transactions have been realized.
Commitments and contingencies
Unrecognized commitments and contingencies as of December 31, 2003 are explained in Note (32).
Other accounting policies
Income and expenses for the year are recognized on an accrual basis. Income from the sale of products, merchandise and services is recognized when delivery has taken place, transfer of risk has been completed, and the amount of future returns can be reasonably estimated.
Product returns are accepted as a matter of contract or as a matter of practice. Product returns were insignificant in the period under review. Sales rebates and discounts as well as amounts collected on behalf of third parties, such as sales taxes and goods and service taxes, are excluded from net sales. Costs for research and development are expensed as incurred.
Income taxes are deferred or accrued on temporary differences between the carrying amount of assets or liabilities in the financial accounts and in their associated tax bases. Deferred taxes relating to consolidation adjustments and tax loss carryforwards are calculated according to the same principle. The recognition of deferred taxes is based on the tax rates enacted or substantively enacted for the subsequent periods when the temporary differences are expected to reverse. Deferred tax assets are recognized only when it is probable that the future economic benefit will be realized. Deferred tax assets and deferred tax liabilities are offset only if they relate to income taxes levied by the same tax authority and the enterprise has a legally enforceable right to offset tax assets against tax liabilities.
Preparation of the consolidated financial statements in accordance with IFRS requires management to make estimates and assumptions affecting the reported amounts of assets, liabilities, revenues and expenses, as well as the disclosure of contingent assets and liabilities. Actual results could differ from these estimates. Such estimates mainly affect provisions for inventory obsolescence, environmental, warranty and litigation risks, the measurement of pension liabilities and the probability of deferred tax assets being recovered against future taxable profits.
(5) Currency translation
Foreign-currency balances included in the financial statements of individual Group companies are translated at the exchange rate on the balance sheet date.
Translation of the financial statements of Group companies located outside the euro zone is based on the appropriate functional currency. The functional currency of such companies is the relevant local currency, as these companies conduct their business independently in financial, economic and organizational respects. As a result, the assets and liabilities of these companies, as well as the Group's share of the equity of foreign associates, are translated at the exchange rate on the balance sheet date. Income and expenses are translated at the average exchange rate for the year. Goodwill arising on the acquisition of an entity located outside the euro zone, and any fair value adjustments to the carrying amounts of assets and liabilities arising on the acquisition of such an entity, are treated as assets and liabilities of that entity and translated at the exchange rate on the balance sheet date. Exchange rate differences are recognized directly as Other comprehensive income.
Currencies which are of particular importance to the Group have experienced the exchange-rate fluctuations shown below:
| Closing rate (basis 1€) | Annual average rate (basis 1€) |
---|
| 2003 | 2002 | 2001 | 2003 | 2002 | 2001 |
---|
U.S. dollar | 1.26 | 1.05 | 0.88 | 1.14 | 0.95 | 0.89 |
Pound sterling | 0.70 | 0.65 | 0.61 | 0.69 | 0.63 | 0.62 |
Brazilian real | 3.66 | 3.71 | 2.05 | 3.48 | 2.71 | 2.08 |
Japanese yen | 135.05 | 124.39 | 115.33 | 131.62 | 118.02 | 108.72 |
B. INCOME STATEMENT DISCLOSURES
(6) Engineering and administration costs
Engineering and administration costs include costs of production management and planning, factory safety and administration, environmental protection, technology cost centers such as workshops, energy production, services and waste disposal (only to the extent that these costs are not internally reallocated to the consuming functions), training, and general administration, such as human resources, purchasing, controlling and accounting.
(7) Other operating income
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Income from foreign currency hedges and monetary transactions | 188 | 133 | 113 |
License and commission income | 42 | 41 | 33 |
Income from providing services to third parties | 51 | 41 | 45 |
Reversal of provisions | 31 | 31 | 25 |
Miscellaneous | 87 | 124 | 132 |
| 399 | 370 | 348 |
Income from providing services to third parties relates to fees from third parties for the supply of technical infrastructure as well as to income from other services provided to third parties. The related expenses are included in Other operating expenses.
(8) Other operating expenses
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Expenses from foreign currency hedges and monetary transactions | 115 | 125 | 137 |
Goodwill amortization | 47 | 46 | 40 |
Costs of providing services to third parties | 46 | 38 | 38 |
Miscellaneous | 85 | 89 | 102 |
| 293 | 298 | 317 |
The net amount of Income and Expenses from foreign currency hedges and monetary transactions includes gains from cash flow hedges of €66m (2002: €35m, 2001: €2m).
(9) Financial result
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Result from investments | | | |
Result from investments in associates | 0 | 44 | 84 |
Impairment of investments | (7) | (26) | (32) |
Disposal of investments | 30 | 1 | 10 |
| 23 | 19 | 62 |
Interest result | | | |
Income from long-term securities and loans | 2 | 2 | 2 |
Other interest and similar income | 21 | 25 | 36 |
Other interest and similar expenses | (10) | (8) | (7) |
Net interest income | 13 | 19 | 31 |
Interest component of additions to provisions for pensions | (35) | (44) | (76) |
| (22) | (25) | (45) |
Other financial result | | | |
Write-downs of loans and marketable securities | 0 | (4) | (12) |
Other financial income | 17 | 13 | 71 |
Other financial expenses | (3) | (26) | (46) |
| 14 | (17) | 13 |
Financial result | 15 | (23) | 30 |
The item Disposal of Investments contains a gain of €22m resulting from the sale of our remaining 49% interest in Oy Leiras Finland AB. In the previous year, the Result from investments in associates included a profit of €45m from our 24% interest in Aventis CropScience Holding S.A., Lyon (Aventis CropScience). We sold this investment at the beginning of June 2002. Our share in the result for the full year 2001 amounted to €85m.
Other financial income and Other financial expenses include gains and losses from the sale of loans and marketable securities, and gains and losses from interest-rate derivative transactions. The previous year’s Other financial expenses included exchange rate losses of €6m (2001: €13m) caused by the monetary crisis in Argentina.
Impairment of investments in 2002 is related to impairment charges on shares in companies in the United States and Europe; in 2001 to impairment charges on shares in companies in the United States.
(10) Income from disposal of Aventis CropScience
The income from the disposal of our 24% interest in Aventis CropScience in fiscal 2002 was composed of the following items:
| €m |
---|
Proceeds from disposal | 1,500 |
Carrying amount* | (526) |
Indemnities | (285) |
Income | 689 |
* After deducting items that had been included in Other comprehensive income |
The indemnities amounting to €285m relate in particular to environmental, tax and product liability risks. The Schering AG Group has entered into a contractual undertaking to the buyer to assume these risks.
(11) Acquisition-related expenses
The Acquisition-related expenses in fiscal 2002 contained one-time effects, primarily expenses of €224m for the acquisition of the rights to the development project for the use of Leukine® in Crohn’s disease, and a further €20m resulting from the establishment of the Schering Stiftung (a foundation under German law) for the promotion of science and culture.
(12) Income taxes
Income before taxes is as follows:
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Domestic | 280 | 567 | 336 |
Foreign | 421 | 578 | 362 |
Total | 701 | 1,145 | 698 |
The respective tax expenses are:
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Domestic | (60) | (32) | (125) |
Foreign | (195) | (244) | (145) |
Total | (255) | (276) | (270) |
The reconciliation of notional tax expenses based on the statutory tax rate applicable to Schering AG of 40.5% (2002: 39.1%; 2001: 39.1%) to tax expenses at the effective tax rate is as follows:
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Income before taxes | 701 | 1,145 | 698 |
Notional tax expenses (at the statutory rate applicable to Schering AG) | (284) | (448) | (273) |
Tax reduction relating to dividends | 30 | 27 | — |
| (254) | (421) | (273) |
Tax effect of non-deductible expenses and tax-free receipts | (6) | 189 | (16) |
Prior-period taxes | (13) | (69) | (17) |
Tax effect of recognizing income from associates net of tax | 0 | 18 | 33 |
Effects of lower tax rates abroad | 18 | 7 | 3 |
Income taxes | (255) | (276) | (270) |
Tax rate | 36.4% | 24.1% | 38.7% |
Current tax expenses | (207) | (360) | (332) |
Deferred tax expenses/income | (48) | 84 | 62 |
Income taxes | (255) | (276) | (270) |
The tax effect of non-deductible expenses and tax-free receipts in the previous year was primarily driven by tax-free receipts from the disposal of Aventis CropScience.
In fiscal 2003, the dividend payment for 2002 reduced the tax expense by €30m. Based on the current regulations, we do not expect any corporate income tax reduction for the dividend payments in 2004 and 2005.
The utilization of tax loss carryforwards reduced tax expenses in 2003 by €1m (2002: €2m; 2001: €4m). Deferred tax assets of €14m relating to tax loss carryforwards were recognized as of December 31, 2003 (December 31, 2002: €25m). As of December 31, 2003, unrecognized tax loss carryforwards totaled €19m (December 31, 2002: €22m). Of these amounts, €14m has no expiration date, while the remainder expires within ten years.
The deferred tax assets and liabilities relate to the following balance sheet items:
| December 31, 2003 | December 31, 2002 |
---|
| Assets | Liabilities | Assets | Liabilities |
---|
| €m | €m | €m | €m |
---|
Intangible assets | 66 | 2 | 115 | 1 |
Property, plant and equipment | (113) | 1 | (109) | 1 |
Inventories | 103 | 6 | 90 | 8 |
Provisions for pensions | 39 | 0 | (5) | (1) |
Other provisions | 42 | (1) | 75 | (3) |
Other | 36 | 5 | 64 | 11 |
| 173 | 13 | 230 | 17 |
The item Other includes deferred tax assets relating to tax loss carryforwards. It also includes deferred tax liabilities of €10m (2002: €16m) which relate to items credited directly to equity. These have been offset against deferred tax assets.
Deferred taxes on property, plant and equipment relate principally to lower tax bases resulting from special tax allowances for assets in certain regions of Germany.
Deferred tax liabilities were not recognized for withholding tax on retained earnings of foreign subsidiaries in the reporting period, because management considers such amounts to be permanently reinvested. Retained earnings of subsidiaries in countries where a withholding tax would be levied in the event of dividend payments totaled €542m (2002: €645m). If such earnings were distributed, withholding tax of €34m (2002: €38m) would be due based on tax rates in effect at the balance sheet date.
(13) Earnings per share
Basic earnings per share are calculated by dividing net profit by the weighted average number of shares outstanding.
| 2003 | 2002 | 2001 |
---|
Net profit (€m) | 443 | 867 | 418 |
Weighted average number of shares outstanding | 194,413,614 | 197,296,507 | 198,000,000 |
Basic earnings per share (€) | 2.28 | 4.39 | 2.11 |
To calculate diluted earnings per share, the weighted average number of shares outstanding is adjusted for all potential dilutive shares. Certain of the Group’s stock option plans (LTI Plan 2000 and the first and second tranche of the LTI 2001 “Key Managers” Plan) represent a potential dilution of earnings per share.
The plans grant Schering AG stock options to senior executives. Exercise of the options depends on certain performance criteria relating to the Schering AG share price which are defined in the stock option plans [see Note (36)].
| 2003 | 2002 | 2001 |
---|
Net profit (€m) | 443 | 867 | 418 |
Weighted average number of shares outstanding | 194,413,614 | 197,296,507 | 198,000,000 |
Adjustment for potential dilutive shares | 296,295 | 573,200 | 926,418 |
Weighted average number of shares (including potential dilutive shares) | 194,709,909 | 197,869,707 | 198,926,418 |
Diluted earnings per share (€) | 2.28 | 4.38 | 2.10 |
The terms of the stock option plans reserve for Schering AG the right to settle claims relating to the exercise of option rights in the form of cash payments instead of issuing shares.
(14) Personnel costs/employees
| 2003 | 2002 | 2001 |
---|
Personnel costs (€m) | | | |
Wages and salaries | 1,245 | 1,278 | 1,240 |
Social security and support payments | 241 | 236 | 221 |
| 1,486 | 1,514 | 1,461 |
Pensions | 88 | 81 | 70 |
| 1,574 | 1,595 | 1,531 |
Number of employees by function (annual average) | | | |
Production | 9,093 | 9,023 | 8,564 |
Marketing and selling | 8,642 | 8,629 | 8,404 |
Research and development | 4,692 | 4,560 | 4,302 |
Administration | 4,134 | 4,033 | 3,786 |
| 26,561 | 26,245 | 25,056 |
Number of employees by Region (annual average) | | | |
Schering AG | 8,320 | 8,223 | 7,746 |
Europe Region | 8,269 | 8,219 | 8,000 |
United States Region | 3,681 | 3,389 | 3,024 |
Japan Region | 1,572 | 1,621 | 1,715 |
Latin America/Canada Region | 2,478 | 2,517 | 2,490 |
Asia/Middle East Region | 1,371 | 1,464 | 1,432 |
Other employees | 870 | 812 | 649 |
| 26,561 | 26,245 | 25,056 |
C. BALANCE SHEET DISCLOSURES
(15) Intangible assets
| Internally developed software | Patents, licenses, trademarks and similar assets | Goodwill | Negative goodwill | Total |
---|
| €m | €m | €m | €m | €m |
---|
Cost | | | | | |
January 1, 2002 | 31 | 365 | 591 | (27) | 960 |
Change in consolidated companies | — | (8) | — | — | (8) |
Additions | 23 | 224 | 118 | — | 365 |
Disposals | 0 | (28) | (14) | 4 | (38) |
Translation adjustments | (3) | (19) | (24) | — | (46) |
December 31, 2002 | 51 | 534 | 671 | (23) | 1,233 |
Change in consolidated companies | — | 0 | — | — | 0 |
Additions | 23 | 24 | 2 | — | 49 |
Disposals | 0 | (36) | — | — | (36) |
Translation adjustments | (2) | (16) | (33) | — | (51) |
December 31, 2003 | 72 | 506 | 640 | (23) | 1,195 |
Accumulated amortization, impairments and reversals | | | | | |
January 1, 2002 | 2 | 114 | 194 | (4) | 306 |
Change in consolidated companies | — | 0 | — | — | 0 |
Additions | 6 | 75 | 46 | (5) | 122 |
Disposals | 0 | (23) | (6) | — | (29) |
Translation adjustments | (1) | (8) | (3) | — | (12) |
December 31, 2002 | 7 | 158 | 231 | (9) | 387 |
Change in consolidated companies | — | 0 | — | — | 0 |
Additions | 11 | 69 | 47 | (4) | 123 |
Disposals | 0 | (26) | — | — | (26) |
Translation adjustments | 0 | (8) | (4) | — | (12) |
December 31, 2003 | 18 | 193 | 274 | (13) | 472 |
Book values as of December 31, 2002 | 44 | 376 | 440 | (14) | 846 |
Book values as of December 31, 2003 | 54 | 313 | 366 | (10) | 723 |
In 2002, additions to Patents, licenses, trademarks and similar assets related mainly to the acquisition cost for the manufacturing and marketing rights to Leukine® in its approved indications. These rights are being amortized over a useful life of eight years.
Additions to goodwill in 2002 related primarily to the acquisition of Collateral Therapeutics in the United States.
(16) Property, plant and equipment
| Land and buildings | Machinery and technical equipment | Other factory and office equipment | Construction in progress and advance payments | Total |
---|
| €m | €m | €m | €m | €m |
---|
Cost | | | | | |
January 1, 2002 | 1,455 | 1,274 | 777 | 86 | 3,592 |
Change in consolidated companies | 11 | (2) | 3 | (1) | 11 |
Additions | 20 | 79 | 89 | 93 | 281 |
Disposals | (107) | (68) | (66) | (1) | (242) |
Transfers | 16 | 37 | 21 | (74) | — |
Translation adjustments | (74) | (39) | (44) | (12) | (169) |
December 31, 2002 | 1,321 | 1,281 | 780 | 91 | 3,473 |
Change in consolidated companies | (1) | 0 | 0 | — | (1) |
Additions | 14 | 72 | 76 | 69 | 231 |
Disposals | (11) | (38) | (71) | (1) | (121) |
Transfers | 12 | 51 | 16 | (79) | — |
Translation adjustments | (52) | (22) | (31) | (7) | (112) |
December 31, 2003 | 1,283 | 1,344 | 770 | 73 | 3,470 |
Accumulated depreciation | | | | | |
January 1, 2002 | 736 | 1,030 | 566 | — | 2,332 |
Change in consolidated companies | 1 | (2) | 1 | — | 0 |
Additions | 42 | 50 | 78 | — | 170 |
Disposals | (51) | (64) | (60) | — | (175) |
Reversal of impairments | — | 0 | 0 | — | 0 |
Transfers | 0 | 0 | 0 | — | — |
Translation adjustments | (30) | (24) | (30) | — | (84) |
December 31, 2002 | 698 | 990 | 555 | — | 2,243 |
Change in consolidated companies | 0 | 0 | 0 | — | 0 |
Additions | 42 | 60 | 77 | 0 | 179 |
Disposals | (8) | (34) | (64) | 0 | (106) |
Reversal of impairments | — | — | — | — | — |
Transfers | 0 | 0 | 0 | — | — |
Translation adjustments | (21) | (15) | (23) | 0 | (59) |
December 31, 2003 | 711 | 1,001 | 545 | — | 2,257 |
Book values as of December 31, 2002 | 623 | 291 | 225 | 91 | 1,230 |
Book values as of December 31, 2003 | 572 | 343 | 225 | 73 | 1,213 |
Additions to Property, plant and equipment decreased by 18% to €231m in 2003. 59% of this expenditure related to Germany, 14% to other countries of the European Union, 16% to the United States, and 2% to Japan. 25% of capital expenditure related to research and development, and 53% to production, quality assurance and environmental protection. 22% was allocated to marketing and selling, and other functions.
(17) Financial assets
| Investments in associates | Other investments | Long-term securities | Sundry loans | Total |
---|
| €m | €m | €m | €m | €m |
---|
Cost | | | | | |
January 1, 2002 | 601 | 115 | 3 | 41 | 760 |
Change in consolidated companies | — | 0 | — | 0 | 0 |
Additions | 42 | 33 | 0 | 5 | 80 |
Disposals | (564) | (16) | 0 | (7) | (587) |
Changes in fair value | — | (31) | — | 0 | (31) |
Translation adjustments | (1) | (15) | 0 | 0 | (16) |
December 31, 2002 | 78 | 86 | 3 | 39 | 206 |
Change in consolidated companies | — | — | — | — | — |
Additions | 10 | 10 | 1 | 26 | 47 |
Disposals | (48) | (29) | (1) | (12) | (90) |
Changes in fair value | — | 3 | — | — | 3 |
Translation adjustments | 0 | (8) | 0 | (1) | (9) |
December 31, 2003 | 40 | 62 | 3 | 52 | 157 |
Accumulated write-downs | | | | | |
January 1, 2002 | 45 | 42 | 0 | 7 | 94 |
Change in consolidated companies | — | — | — | — | — |
Additions | 8 | 26 | 0 | 0 | 34 |
Disposals | (2) | 0 | — | 0 | (2) |
Reversals | (32) | — | — | (1) | (33) |
Translation adjustments | — | (7) | — | 0 | (7) |
December 31, 2002 | 19 | 61 | 0 | 6 | 86 |
Change in consolidated companies | — | — | — | — | — |
Additions | 7 | 7 | 0 | 3 | 17 |
Disposals | (7) | (18) | — | (3) | (28) |
Reversals | — | — | — | (1) | (1) |
Translation adjustments | — | (6) | — | 0 | (6) |
December 31, 2003 | 19 | 44 | 0 | 5 | 68 |
Book values as of December 31, 2002 | 59 | 25 | 3 | 33 | 120 |
Book values as of December 31, 2003 | 21 | 18 | 3 | 47 | 89 |
Disposals of Investments in associates in 2003 relate in part to our 49% interest in Oy Leiras Finland AB, amounting to €21m. Additions to Investments in associates in 2002 mainly related to our 49% interest in Oy Leiras Finland AB, amounting to €21m.
The disposals of Investments in associates in the previous year particularly related to the sale of our interest in Aventis CropScience (€556m) and to dividend payments.
Fair value changes in marketable investments of €3m (2002: €(31)m) before taxes were recognized directly in Other comprehensive income after deducting deferred taxes. Other investments which were considered to be impaired resulted in impairment charges of €7m (2002: €26m).
Sundry loans include €20m (December 31, 2002: €25m) relating to mortgage loans to employees.
Changes in carrying amounts of Investments in associates:
| Aventis CropScience | Other associates | Total |
---|
| €m | €m | €m |
---|
January 1, 2002 | 512 | 44 | 556 |
Profit/loss shares (1) | 45 | (1) | 44 |
Dividend payments | 0 | (6) | (6) |
Additions | 0 | 22 | 22 |
Disposals | (556) | 0 | (556) |
Translation adjustments | (1) | 0 | (1) |
December 31, 2002 | 0 | 59 | 59 |
Profit/loss shares(1) | — | 0 | 0 |
Dividend payments | — | (7) | (7) |
Additions | — | 3 | 3 |
Disposals | — | (34) | (34) |
Translation adjustments | — | 0 | 0 |
December 31, 2003 | — | 21 | 21 |
(1) After deduction of goodwill amortization |
(18) Inventories
| Dec. 31, 2003 | Dec. 31, 2002 |
---|
| €m | €m |
---|
Raw materials and supplies | 212 | 199 |
Work in process | 429 | 395 |
Finished goods and goods for resale | 352 | 373 |
Payments on account | 3 | 4 |
| 996 | 971 |
Inventories as of December 31, 2003 include €66m carried at net realizable values that are lower than their cost (December 31, 2002: €33m).
(19) Trade receivables
Trade receivables as of December 31, 2003 include €21m with a remaining term of more than one year (December 31, 2002: €14m). Allowances for doubtful accounts on trade receivables as of December 31, 2003 amounted to €25m (December 31, 2002: €22m).
(20) Other receivables and other assets
| Dec. 31, 2003 | Dec. 31, 2002 |
---|
| €m | €m |
---|
Current tax assets | 178 | 102 |
Deferred tax assets | 173 | 230 |
Sundry assets | 190 | 182 |
| 541 | 514 |
Other receivables and other assets include €199m with a remaining term of more than one year (December 31, 2002: €246m).
(21) Marketable securities
Marketable securities are accounted for at fair value. Fair values as of December 31, 2003 included unrealized gains of €1m (December 31, 2002: €6m) that are recognized net of deferred taxes in Accumulated other comprehensive income.
(22) Paid-up capital
As of December 31, 2003, issued capital amounted to €194,000,000 (2002: €196,500,000; 2001: €198,000,000) and is composed of 194,000,000 no-par value shares, with each share representing €1.00 of the issued capital.
During the reporting period, 2,500,000 treasury shares were purchased and redeemed for a total of €90.2m. The Supervisory Board amended the Articles of Association accordingly. These shares accounted for €2.5m of paid-up capital, which was reduced accordingly. Under section 237 (5) of the German Stock Corporation Act (Aktiengesetz), an equivalent amount has been withdrawn from retained earnings and added to the capital reserve. In 2002, 1,5000,000 treasury shares were purchased and redeemed for a total of €76.0m.
In 2003, Schering AG purchased 242,660 treasury shares for an average price of €43.62 per share for the issuance of employee shares. The shares were offered to qualified employees at €17.00 per share.
In 2002, Schering AG purchased 181,968 treasury shares for an average price of €66.48 per share for the issuance of employee shares. The shares were offered to qualified employees at €24.80 per share.
For the acquisition of Collateral Therapeutics in 2002 through a stock swap, Schering AG purchased 2,451,659 treasury shares at an average price of €64.27 per share between April and June of 2002. These treasury shares have been distributed to the shareholders of Collateral Therapeutics.
The Executive Board is authorized to purchase treasury shares until September 30, 2004 for purposes codified in section 71 (1) No. 8 of the German Stock Corporation Act. In total, up to €15,000,000 in issued capital may be acquired under this authorization.
Furthermore, the Executive Board is authorized until April 26, 2004, to increase issued capital with the approval of the Supervisory Board on one or on several occasions by issuing new shares for cash or non-cash consideration, provided that the overall increase in issued capital does not exceed a total amount of €85,000,000 and that the shareholders are given the right to subscribe. With the agreement of the Supervisory Board, however, the Executive Board is authorized to issue shares without giving the shareholders the right to subscribe:
(a) if the capital increase from cash proceeds does not exceed a total amount of €15,000,000 and the issue price of the new shares is not substantially below the quoted market price for the shares at the time the issue price is determined by the Executive Board; or
(b) if the capital increase is effected for the issue of employee shares; or
(c) if the capital increase is effected for non-cash consideration; or
(d) to the extent necessary to allow holders of convertible bonds or bonds with warrants of Schering AG to subscribe to the new shares.
The Executive Board is also authorized, with the agreement of the Supervisory Board, to issue convertible bonds and/or bonds with warrants on one or on several occasions in the period up to April 26, 2004. The total nominal value of such bond issues may not exceed €300,000,000. Conversion rights or options on Schering AG shares may be issued up to a total of €11,538,462 of issued capital. Accordingly, the issued capital of Schering AG may be increased by up to €11,538,462 through the issue of up to 11,538,462 shares (Contingent capital I). This contingent increase in issued capital serves solely to exercise conversion rights and options. Furthermore, the issued capital of Schering AG may be increased by up to €5,000,000 (Contingent capital II). This contingent increase in issued capital will only be implemen ted to the extent that holders of option rights that have been issued until September 30, 2003, on the basis of the Annual General Meeting’s authorization of April 26, 2001 exercise their option rights and that claims are not settled by the transfer of treasury shares or cash payments.
(23) Retained earnings
Retained earnings comprise Other retained earnings and Accumulated other comprehensive income.
The Executive Board will propose to the General Meeting a dividend of € 0.93 per share (totaling €180m) for fiscal year 2003.
(24) Provisions for pensions and similar obligations
| Dec. 31, 2003 | Dec. 31, 2002 |
---|
| €m | €m |
---|
Provisions for retirement benefit obligations in Germany | 458 | 439 |
Provisions for retirement benefit obligations outside Germany | 72 | 70 |
Provisions for similar obligations | 46 | 51 |
| 576 | 560 |
Pension benefits in Germany are primarily determined by years of service and average remuneration in the final five years prior to retirement.
Defined benefit plans of Schering AG are funded to a substantial extent by a pension trust ( Schering Altersversorgung Treuhand Verein). In 2002, a one-time payment of €500m had been transferred to this trust in addition to regular contributions.
Defined benefit plans of foreign subsidiaries, which are primarily service-related, are generally funded.
We consider projected service costs and the expected return on plan assets when calculating the net periodic pension costs for these plans. Changes in the projected benefit obligation (PBO) and the fair value of plan assets were as follows:
| German plans | Other plans |
---|
| 2003 | 2002 | 2003 | 2002 |
---|
| €m | €m | €m | €m |
---|
Change in projected benefit obligation | | | | |
PBO at beginning of the year | 1,345 | 1,303 | 309 | 315 |
Service cost | 30 | 36 | 25 | 22 |
Interest cost | 76 | 78 | 17 | 17 |
Actuarial (gains) and losses | 22 | (17) | 75 | 2 |
Benefits paid | (60) | (52) | (14) | (15) |
Transfer of obligations | 1 | (3) | — | — |
Translation adjustments | — | — | (36) | (32) |
PBO at end of year | 1,414 | 1,345 | 376 | 309 |
Change in plan assets | | | | |
Fair value of plan assets at beginning of the year | 730 | 304 | 182 | 210 |
Actual return on plan assets | 128 | (64) | 14 | (18) |
Employer contribution | 18 | 522 | 26 | 20 |
Contributions by plan participants | — | — | 1 | 1 |
Benefits paid | (38) | (32) | (11) | (12) |
Translation adjustments | — | — | (19) | (19) |
Fair value of plan assets at end of year | 838 | 730 | 193 | 182 |
Funded status | 576 | 615 | 183 | 127 |
Unrecognized actuarial losses | (118) | (176) | (111) | (57) |
Provisions for pensions | 458 | 439 | 72 | 70 |
Net periodic pension costs of defined benefit plans and total pension costs were as follows:
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Service cost | 55 | 58 | 47 |
Interest cost | 93 | 95 | 91 |
Expected return on plan assets | (60) | (52) | (13) |
Amortization of unrecognized actuarial gains and losses | 10 | 3 | 2 |
Net periodic pension costs of defined benefit plans | 98 | 104 | 127 |
Costs of defined contribution plans and other pension costs | 25 | 21 | 19 |
Total pension costs | 123 | 125 | 146 |
The interest cost on pension obligations not transferred to external funds is reported under the Interest result [see Note (9)]. The other pension expenses are charged as personnel expenses to the costs of the operating functions [see Note (14)].
For a foreign multi-employer defined benefit plan the necessary information to account for the plan as a defined benefit plan is not available to us. The plan is accounted for as a defined contribution plan.
Measurement date for the fair value of plan assets is December 31. The parameters and assumptions described in Note (4) were applied. These parameters are also applied in the following year in determining interest cost, service cost and the expected return on plan assets. The basis for the add back of interest cost to discounted pension obligations is the projected benefit obligation on January 1. The basis for the expected return on plan assets is the fair value on January 1; allocations during the year are included ratably. The basis for the amortization of actuarial gains and losses is the amount calculated as of January 1, to the extent to which such amounts exceed 10% of the obligation.
The portfolio structure of domestic plan assets at the balance sheet date and the target structure are as follows:
Asset class | Portfolio structure of plan assets |
---|
| Target structure | December 31, 2003 | December 31, 2002 |
---|
Equities | 45% | 46% | 38% |
Hedge funds | 20% | 13% | 20% |
Bonds | 35% | 31% | 37% |
Others | 0% | 10% | 5% |
| 100% | 100% | 100% |
The differences between the actual and target allocations are due in part to market price developments, and in part to risk management efforts based on market expectations. At the end of 2002 and beginning of 2003, cash funds were invested in equities to approximate their target allocation after the decline in equity prices. During 2003, investments in corporate and emerging market bonds were reduced due to a fall in spreads and yields. The lower proportion of hedge funds at the year-end is due to the start of diversification into other products of the same class, which has not yet been completed.
The use of derivatives is allowed, as we fully hedge the currency risks and also transform the interest rate exposure in other currencies into the euro interest curve. We also employ a risk management system to calculate historical worst-case scenarios of given portfolios.
The expected rate of return of 7% is based on historical and expected future averages for risk premiums and absolute returns of the asset classes analyzed. They are also cross-checked against market expectations of external sources. We consider the resulting return assumptions as realistic within the long-term investment horizon of a pension trust. Since its inception at the end of 2001 the compounded annual average rate of return of the assets in our domestic pension trust was approximately 4.9%.
The expected contributions to plan assets in 2004 amount to €18m.
(25) OTHER PROVISIONS
| January 1, 2003 | | December 31, 2003 |
---|
| Current | Total | Additions | Use | Reversals | Change in consolidated companies | Translation adjustment | Total | Current |
---|
Provisions for | €m | €m | €m | €m | €m | €m | €m | €m | €m |
---|
Current tax | 239 | 239 | 98 | (67) | (16) | — | (5) | 249 | 249 |
Deferred tax | — | 17 | 47 | (48) | — | — | (3) | 13 | — |
Personnel costs | 243 | 342 | 239 | (221) | (9) | 0 | (19) | 332 | 229 |
Third-party claims | 9 | 318 | 9 | (2) | (1) | — | (7) | 317 | 40 |
Environmental matters | 11 | 79 | 5 | (5) | 0 | — | (2) | 77 | 11 |
Restructuring | 10 | 26 | 6 | (5) | (7) | — | 0 | 20 | 11 |
Other | 137 | 141 | 117 | (95) | (13) | — | (13) | 137 | 120 |
| 649 | 1,162 | 521 | (443) | (46) | 0 | (49) | 1,145 | 660 |
| January 1, 2002 | | December 31, 2002 |
---|
| Current | Total | Additions | Use | Reversals | Change in consolidated companies | Translation adjustment | Total | Current |
---|
Provisions for | €m | €m | €m | €m | €m | €m | €m | €m | €m |
---|
Current tax | 120 | 120 | 201 | (75) | 0 | — | (7) | 239 | 239 |
Deferred tax | — | 49 | 17 | (42) | (2) | 0 | (5) | 17 | — |
Personnel costs | 240 | 333 | 260 | (212) | (15) | (1) | (23) | 342 | 243 |
Third-party claims | 15 | 44 | 286 | (2) | (5) | — | (5) | 318 | 9 |
Environmental matters | 11 | 50 | 5 | (4) | 0 | 32 | (4) | 79 | 11 |
Restructuring | 5 | 7 | 18 | (6) | — | 7 | — | 26 | 10 |
Other | 145 | 154 | 116 | (105) | (9) | 0 | (15) | 141 | 137 |
| 536 | 757 | 903 | (446) | (31) | 38 | (59) | 1,162 | 649 |
Provisions for personnel costs include accrued salaries (vacation and holiday, bonuses, and jubilee benefits), as well as early retirement benefits. Provisions for third-party claims include indemnities relating to the sale of investments and business activities as well as expected costs in the event of patent infringement litigation. Provisions for environmental expenses include clean-up obligations in Germany, France and the United States. Provisions for restructuring largely include severance obligations to employees and other closure-related costs incurred in the context of the realization of our Global Production Strategy.
(26) Liabilities
| Dec. 31, 2003 | Dec. 31, 2002 |
---|
| Current | Total | Current | Total |
---|
| €m | €m | €m | €m |
---|
Bank loans and overdrafts | 74 | 110 | 53 | 91 |
Trade payables | 352 | 354 | 359 | 361 |
Taxes payable | 74 | 75 | 61 | 61 |
Social security costs payable | 34 | 34 | 31 | 31 |
Payables to employees | 28 | 38 | 26 | 38 |
Miscellaneous | 126 | 139 | 128 | 139 |
| 688 | 750 | 658 | 721 |
(27) Total amount of collateralized loans
The total amount of collateralized loans as of December 31, 2003 (all collateralized by mortgages) was €33m (December 31, 2002: €41m).
D. CASH FLOW STATEMENT DISCLOSURES
(28) Cash and cash equivalents
Cash and cash equivalents include bank deposits and cash on hand.
(29) Cash flows from operating activities
Cash flows from operating activities included interest received of €22m (2002: €28m; 2001: €37m) and interest paid of €10m (2002: €8m; 2001: €6m). Payments of income taxes amounted to €259m (2002: €274m; 2001: €214m).
In 2002, Other non-cash expenses and income included our share of the profit from Aventis CropScience of €45m (2001: €85m).
The result from disposal of fixed assets includes a profit of €22m from the sale of our remaining 49% interest in Oy Leiras Finland AB. In 2002, this item mainly included income from the disposal of Aventis CropScience.
(30) Cash flows used in/from investing activities
Purchase of fixed assets in 2002 included the acquisition cost of the manufacturing and marketing rights to Leukine® in its approved indications. The part of the acquisition cost relating to the project to develop Leukine® in the indication of Crohn’s disease has been recognized separately.
The Proceeds from disposal of fixed assets include €43m from the sale of our remaining 49% interest in OY Leiras Finland AB. In 2002, this position included €1.5bn relating to the sale of our interest in Aventis CropScience.
The purchase and sale of marketable securities comprises purchases of €103m (2002: €196m; 2001: €79m) and sales of securities of €139m (2002: €31m; 2001: €379m). The proceeds in 2001 included €250m from the transfer of securities to the Schering Pension Trust.
Cash flows used in Acquisitions net of cash acquired in the reporting period relate to the acquisition of minority interests in two group companies. In 2002, this item essentially related to the acquisition of the remaining 88.1% interest in Collateral Therapeutics (2001: acquisition of the remaining 25.1% interest in the Jenapharm Group and remaining 40% interest in the French radiopharmaceuticals company CIS bio). The allocation of the purchase consideration paid to assets and liabilities is as follows:
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Fixed assets | — | 5 | 68 |
Other non-current and current assets | — | 48 | 4 |
Provisions and liabilities | — | (10) | (33) |
Minority interest | 0 | — | 85 |
Goodwill | 2 | 118 | 48 |
| 2 | 161 | 172 |
Issue of treasury shares | — | (148) | — |
Purchase of minority interest in prior years | — | (6) | — |
Cash acquired | — | (15) | (1) |
Cash flows used in Acquisitions net of cash acquired | 2 | (8) | 171 |
E. SUPPLEMENTAL DISCLOSURES
(31) Derivative financial instruments
As we operate on a global basis, the Schering AG Group is subject to various market risks. We make use of exchange-traded and over-the-counter derivative financial instruments to reduce currency and interest-rate risks resulting from anticipated transactions and from existing assets and liabilities. We use derivative financial instruments to manage the asset and maturity profile of our investment portfolio.
Market risks resulting from open derivative positions are estimated by a risk assessment system using a simulation of historical data. Various measures have been put in place to manage the risks. These include the definition of limits for individual classes of instruments, the organizational segregation of dealing, settlement and accounting as well as supervision, and the regular reporting on open positions and results based on mark-to-market valuations. The following derivative positions were open at the balance sheet date:
| Notional amount December 31, | Fair value December 31, |
---|
| 2003 | 2002 | 2003 | 2002 |
---|
| €m | €m | €m | €m |
---|
Currency hedging of anticipated sales and expenses | | | | |
Currency forwards | 471 | 519 | 10 | 13 |
Options | 8 | 75 | 0 | 2 |
| 479 | 594 | 10 | 15 |
Currency hedging of assets and liabilities | | | | |
Currency forwards | 251 | 362 | 5 | 4 |
Asset and liability management | | | | |
Options | 83 | 34 | 14 | 6 |
Swaps | 5 | 0 | 2 | 0 |
Interest-rate futures | 76 | 69 | 0 | 1 |
| 164 | 103 | 16 | 7 |
Notional amounts reflect the net of sale and purchase contracts. The underlying exposure in each currency is defined as the net amount of receivables and liabilities on the balance sheet date as well as anticipated sales and expenses for the next 12 months. As of December 31, 2003, approximately 66% (December 31, 2002: 71%) of the underlying exposure of €1.1bn (December 31, 2002: €1.3bn) was hedged. Yen and U.S. dollar amounts accounted for approximately 62% (December 31, 2002: 73%) of currency hedging.
The measurement of hedging instruments at fair value is based on quoted market prices or reference rates such as the ECB reference rates, or on the application of established valuation models such as the Black-Scholes model. Changes in fair values are recognized in Other receivables and other assets and Other provisions respectively.
In order to properly match gains and losses on hedging instruments, hedge gains and losses attributable to anticipated sales and expenses are deferred until the underlying hedged transaction is realized. Gains and losses on hedging instruments are recognized net of tax as Other comprehensive income. They are reversed to income when the underlying hedged transactions are realized. These gains or losses are recognized in Other operating income.
As of December 31, 2003, we recognized gains of €24m (net of tax: €15m) resulting from 2003 hedging contracts in Accumulated other comprehensive income, since they are attributable to sales and expenses in 2004 (December 31, 2002: €39m; net of tax €24m).
Accordingly in 2003, we recognized gains of €39m (net of tax: €24m) resulting from 2002 hedging contracts in Other operating income, since these gains are attributable to sales and expenses realized in 2003 (December 31, 2002: €6m; net of tax €4m).
Changes in fair values resulting from currency hedging of existing assets and liabilities are recognized in Other operating income. These gains and losses generally correspond to changes in the hedged balance sheet items.
Changes in fair values relating to Schering AG call options acquired for the hedging of stock option plans are included in personnel expenses.
Changes in fair values of derivatives relating to asset and liability management are included in the Financial result.
At the balance sheet date, our net financial position based on cash and cash equivalents plus marketable securities and bank loans was €629m (December 31, 2002: €566m). The average maturity of fixed-rate interest bearing securities and fixed-rate deposits including financial derivatives was approximately 1.4 years (December 31, 2002: approximately 1.7 years).
The credit risks arising from derivative financial instruments are limited to the positive fair values of these derivatives. In order to minimize those credit risks, investments and transactions in derivative instruments are entered into only with prime-rated debtors and banks within fixed risk limits.
(32) Contingent liabilities and other financial commitments
| Dec. 31, 2003 | Dec. 31, 2002 |
---|
| €m | €m |
---|
Contingent liabilities | | |
Financial guarantees | 27 | 23 |
| 27 | 23 |
Other financial commitments | | |
Liabilities under operating leases | | |
due within 1 year | 49 | 47 |
due in 1 to 5 years | 101 | 100 |
due after 5 years | 43 | 47 |
Authorized capital expenditure | 285 | 300 |
| 478 | 494 |
As of December 31, 2003 we had issued financial guarantees of €27m (December 31, 2002: €23m) which are related to transactions arising from the normal course of business.
The Schering AG Group has entered into long-term agreements with various third parties, under which the Group makes payments in connection with various research and development projects based upon the achievement of certain milestones or other specific conditions. In return, the Group obtains product rights or licenses to market the developed products, such as Campath®/MabCampath™ (partner: ILEX Oncology, Inc.) and Zevalin® (partner: Biogen Idec Inc.). The estimated payments to these third parties, assuming the agreed milestones and other conditions are met, will be as follows:
| €m |
---|
2004 | 71 |
2005 | 43 |
2006 | 25 |
2007 | 43 |
2008 | — |
Thereafter | — |
| 182 |
(33) Segment reporting
| Segment net sales | Internal net sales | External net sales | Change from last year |
---|
| €m | €m | €m | |
---|
2003 | | | | |
Europe Region(1) | 3,278 | 891 | 2,387 | 1% |
United States Region | 1,209 | 6 | 1,203 | (6%) |
Japan Region | 517 | 0 | 517 | (11%) |
Latin America/Canada Region | 454 | 71 | 383 | (11%) |
Asia/Middle East Region | 212 | 13 | 199 | (11%) |
Other Activities | 183 | 44 | 139 | (8%) |
Segment total | 5,853 | 1,025 | 4,828 | (4%) |
Other | — | — | — | — |
Schering AG Group | 5,853 | 1,025 | 4,828 | (4%) |
2002 | | | | |
Europe Region(1) | 3,266 | 909 | 2,357 | 8% |
United States Region | 1,288 | 6 | 1,282 | 15% |
Japan Region | 580 | 1 | 579 | (13%) |
Latin America/Canada Region | 480 | 50 | 430 | (16%) |
Asia/Middle East Region | 236 | 12 | 224 | 5% |
Other Activities | 206 | 55 | 151 | (4%) |
Segment total | 6,056 | 1,033 | 5,023 | 4% |
Other | — | — | — | — |
Schering AG Group | 6,056 | 1,033 | 5,023 | 4% |
2001 | | | | |
Europe Region(1) | 3,041 | 858 | 2,183 | 9% |
United States Region | 1,121 | 8 | 1,113 | 12% |
Japan Region | 663 | — | 663 | (1%) |
Latin America/Canada Region | 540 | 29 | 511 | 8% |
Asia/Middle East Region | 222 | 9 | 213 | 8% |
Other Activities | 257 | 98 | 159 | 5% |
Segment total | 5,844 | 1,002 | 4,842 | 8% |
Other | — | — | — | — |
Schering AG Group | 5,844 | 1,002 | 4,842 | 8% |
(1) Incl. Africa, Australia and New Zealand |
Our primary segment reporting format is geographic, based on the location of the customers. This reflects the management structure of our sales organization, our system of internal financial reporting, and the predominant source of risks and returns in our business. Segment reporting is therefore divided into five geographic segments. Other Activities (mainly our pharmaceutical chemicals business) are managed on a worldwide basis and are therefore also presented as a separate segment.
Segment net sales include both sales to third parties (external net sales) and sales to Group companies belonging to a different region (internal net sales). Inter-segment sales are determined at arm's length prices.
Information on External net sales is generally based on the location of the customer. However, based on our management reporting format, net sales figures of the Europe Region also include the net sales of the subsidiaries Schering Oy (formerly Leiras Oy), Jenapharm, CIS bio international and Justesa Imagen Group, generated outside Europe. Net sales reported for the United States Region also include net sales of the Medrad Group generated outside the United States.
| Segment performance | Change from last year | Central production overhead/ variances | Research and development expenses | Segment result | Change from last year |
---|
| €m | | €m | €m | €m | |
---|
2003 | | | | | | |
Europe Region(1) | 1,031 | (1%) | (73) | (426) | 532 | (3%) |
United States Region | 394 | 8% | (15) | (254) | 125 | 20% |
Japan Region | 202 | (12%) | (13) | (101) | 88 | (17%) |
Latin America/Canada Region | 137 | (4%) | (8) | (79) | 50 | 16% |
Asia/Middle East Region | 68 | (17%) | (15) | (39) | 14 | (52%) |
Other Activities | 57 | (24%) | (38) | (25) | (6) | (138%) |
Segment total | 1,889 | (2%) | (162) | (924) | 803 | (5%) |
Other | -1,203 | 1% | 162 | 924 | (117) | 11% |
Schering AG Group | 686 | (7%) | — | — | 686 | (7%) |
2002 | | | | | | |
Europe Region(1) | 1,040 | 13% | (62) | (430) | 548 | 19% |
United States Region | 366 | 16% | (11) | (251) | 104 | 44% |
Japan Region | 229 | (6%) | (14) | (109) | 106 | (1%) |
Latin America/Canada Region | 143 | (16%) | (7) | (93) | 43 | (55%) |
Asia/Middle East Region | 82 | 14% | (13) | (40) | 29 | (19%) |
Other Activities | 75 | (6%) | (35) | (24) | 16 | (52%) |
Segment total | 1,935 | 7% | (142) | (947) | 846 | 5% |
Other | (1,194) | 5% | 142 | 947 | (105) | (22%) |
Schering AG Group | 741 | 11% | — | — | 741 | 11% |
2001 | | | | | | |
Europe Region(1) | 922 | 13% | (60) | (402) | 460 | 14% |
United States Region | 315 | 8% | (8) | (235) | 72 | 71% |
Japan Region | 244 | (1%) | (15) | (122) | 107 | (1%) |
Latin America/Canada Region | 170 | 12% | (7) | (68) | 95 | 9% |
Asia/Middle East Region | 72 | 4% | (12) | (24) | 36 | 0% |
Other Activities | 80 | 10% | (34) | (13) | 33 | 27% |
Segment total | 1,803 | 9% | (136) | (864) | 803 | 15% |
Other | (1,135) | 12% | 136 | 864 | (135) | 121% |
Schering AG Group | 668 | 4% | — | — | 668 | 4% |
(1) Incl. Africa, Australia and New Zealand |
Segment performance and Segment result are presented on a consolidated basis to ensure comparability with external net sales. Segment performance is an internal financial reporting measurement utilized by our management. Under this approach, transfers from our centralized production facilities in Europe are charged to the segments at standard production cost. Research and development expenses are not included, as this function is managed on a worldwide basis.
The Segment result comprises Segment performance less an allocation of research and development expenses and central production overhead and production variances. Research and development expenses specifically attributable to individual segments are allocated directly, while all other expenses incurred by our corporate research and development organization (such as general research, global development activities, and infrastructure) are allocated to the segments on the basis of sales. Central production overhead and production variances are allocated on the basis of the production supplied from our central production facilities to the individual segments.
The total of the Segment results is reconciled to the consolidated Operating profit as follows:
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Total of Segment results | 803 | 846 | 803 |
Costs of corporate functions | (198) | (198) | (188) |
Other income/expenses | 81 | 93 | 53 |
Total other | (117) | (105) | (135) |
Operating profit | 686 | 741 | 668 |
The Cost of corporate functions comprises administration costs of Schering AG. Income and expenses which were not incurred by the segments and/or arose in the course of unusual transactions are summarized in Other income/expenses.
Depreciation by segment includes amortization of intangible assets and depreciation of property, plant and equipment. Other significant non-cash expenses principally contain pension expenses shown under Operating profit. Segment assets include all assets with the exception of assets relating to corporate functions, financial assets, other receivables and other assets, marketable securities and cash and cash equivalents. Segment liabilities include all liabilities with the exception of liabilities allocated to corporate functions, financial liabilities and tax liabilities, which are included under Other. Financial liabilities mainly consist of €458m (December 31, 2002: €439m) pension obligations from German retirement benefit plans. The corresponding €35m (2002: €44m) in interest costs is included in the Financial result.
| Depreciation | Other significant non-cash expenses | Segment assets | Segment liabilities | Investments in intangibles and property, plant and equipment | Segment assets by geographical location | Investments by geographical location |
---|
| €m | €m | €m | €m | €m | €m | €m |
---|
2003 | | | | | | | |
Europe Region(1) | 105 | 8 | 2,110 | 815 | 103 | 2,497 | 158 |
United States Region | 101 | 1 | 819 | 228 | 53 | 623 | 41 |
Japan Region | 20 | 6 | 386 | 62 | 15 | 334 | 7 |
Latin America/Canada Region | 14 | — | 175 | 28 | 21 | 145 | 16 |
Asia/Middle East Region | 10 | — | 114 | 4 | 17 | 77 | 8 |
Other Activities | 13 | — | 111 | 5 | 22 | 39 | 3 |
Segment total | 262 | 15 | 3,715 | 1,141 | 231 | 3,715 | 231 |
Other | 40 | 2 | 1,674 | 1,330 | 49 | 1,674 | 49 |
Schering AG Group | 302 | 17 | 5,389 | 2,471 | 280 | 5,389 | 280 |
2002 | | | | | | | |
Europe Region(1) | 101 | 10 | 2,035 | 802 | 193 | 2,429 | 386 |
United States Region | 108 | 5 | 927 | 263 | 287 | 719 | 162 |
Japan Region | 21 | — | 441 | 53 | 31 | 383 | 9 |
Latin America/Canada Region | 16 | — | 168 | 31 | 42 | 135 | 29 |
Asia/Middle East Region | 5 | — | 115 | 7 | 16 | 83 | 5 |
Other Activities | 10 | — | 134 | 6 | 28 | 71 | 6 |
Segment total | 261 | 15 | 3,820 | 1,162 | 597 | 3,820 | 597 |
Other | 31 | 4 | 1,572 | 1,281 | 49 | 1,572 | 49 |
Schering AG Group | 292 | 19 | 5,392 | 2,443 | 646 | 5,392 | 646 |
2001 | | | | | | | |
Europe Region(1) | 99 | 20 | 1,848 | 795 | 156 | 2,042 | 279 |
United States Region | 65 | 10 | 768 | 259 | 133 | 729 | 54 |
Japan Region | 27 | 9 | 488 | 50 | 27 | 445 | 16 |
Latin America/Canada Region | 14 | — | 249 | 50 | 28 | 223 | 22 |
Asia/Middle East Region | 9 | — | 116 | 9 | 17 | 88 | 8 |
Other Activities | 16 | — | 165 | 16 | 27 | 107 | 9 |
Segment total | 230 | 39 | 3,634 | 1,179 | 388 | 3,634 | 388 |
Other | 24 | 13 | 1,629 | 1,513 | 35 | 1,629 | 35 |
Schering AG Group | 254 | 52 | 5,263 | 2,692 | 423 | 5,263 | 423 |
(1) Incl. Africa, Australia and New Zealand |
Our secondary segment reporting format is based on the Business Areas:
| External net sales | Change from last year | Segment assets | Investments in intangibles and property, plant and equipment |
---|
| €m | | €m | €m |
---|
2003 | | | | |
Gynecology&Andrology(1) | 1,622 | 1% | 1,163 | 76 |
Specialized Therapeutics | 1,560 | (5%) | 1,202 | 59 |
Diagnostics&Radiopharmaceuticals | 1,312 | (7%) | 1,056 | 63 |
Dermatology | 200 | (7%) | 180 | 14 |
Other Sources | 134 | (10%) | 114 | 19 |
Segment total | 4,828 | (4%) | 3,715 | 231 |
Other | — | — | 1,674 | 49 |
Schering AG Group | 4,828 | (4%) | 5,389 | 280 |
2002 | | | | |
Gynecology&Andrology(1) | 1,613 | 7% | 1,131 | 102 |
Specialized Therapeutics | 1,637 | 10% | 1,262 | 373 |
Diagnostics&Radiopharmaceuticals | 1,406 | (3%) | 1,109 | 83 |
Dermatology | 217 | (5%) | 191 | 18 |
Other Sources | 150 | (7%) | 127 | 21 |
Segment total | 5,023 | 4% | 3,820 | 597 |
Other | — | — | 1,572 | 49 |
Schering AG Group | 5,023 | 4% | 5,392 | 646 |
2001 | | | | |
Gynecology&Andrology | 1,510 | 12% | 1,069 | 131 |
Specialized Therapeutics | 1,491 | 6% | 1,044 | 153 |
Diagnostics&Radiopharmaceuticals | 1,452 | 7% | 1,199 | 73 |
Dermatology | 227 | 3% | 195 | 15 |
Other Sources | 162 | 3% | 127 | 16 |
Segment total | 4,842 | 8% | 3,634 | 388 |
Other | — | — | 1,629 | 35 |
Schering AG Group | 4,842 | 8% | 5,263 | 423 |
(1) In 2002, the business area Fertility Control&Hormone Therapy was renamed Gynecology&Andrology. |
(34) Information on principal companies included in the consolidated financial statements
The table below contains information on principal companies included in the consolidated financial statements as of and for the year ended December 31, 2003 [the complete list of the Group's ownership interests is filed with the Commercial Register of the Amtsgericht Charlottenburg (Charlottenburg Local Court), Berlin]:
Name and location of company | % of Equity | Equity | Result | Sales | Employees |
---|
| | €m(1) | €m(1) | €m(1) | |
---|
Germany | | | | | |
Schering AG, Berlin(2) | | 1,563 | 442 | 2,338 | 8,283 |
Schering Deutschland Holding AG, Hamburg(3) | 100.0 | 276 | 29 | 408 | 616 |
Jenapharm GmbH&Co. KG, Jena(3) | 100.0 | 47 | 41 | 163 | 1,069 |
Schering Finnland Holding GmbH, Berlin | 100.0 | 207 | 29 | — | — |
Europe (excluding Germany) | | | | | |
N.V. Schering S.A., Diegem/Belgium | 100.0 | 24 | 2 | 71 | 148 |
Schering Oy, Turku, Finland(3) | 100.0 | 179 | 49 | 221 | 878 |
Schering S.A., Lys-Lez-Lannoy/France(3) | 99.9 | 193 | 3 | 393 | 1,554 |
Schering Holdings Ltd., Burgess Hill/UK(3) | 100.0 | 24 | 10 | 155 | 325 |
Schering S.p.A., Milan/Italy(3) | 100.0 | 92 | 22 | 315 | 882 |
Schering Nederland B.V., Weesp/Netherlands | 100.0 | 37 | 5 | 65 | 92 |
Schering Wien Ges.m.b.H., Vienna/Austria | 100.0 | 297 | 8 | 63 | 110 |
Schering Lusitana Lda., Mem Martins/Portugal | 100.0 | 15 | 2 | 53 | 133 |
Schering (Schweiz) AG, Baar/Switzerland | 100.0 | 10 | 3 | 64 | 79 |
Schering España S.A., Madrid/Spain(3) | 99.9 | 92 | 16 | 214 | 667 |
Schering Alman Ilac ve Ecza Ticaret Ltd., Sirketi, Istanbul/Turkey | 100.0 | 11 | 0 | 61 | 171 |
North America | | | | | |
Schering Berlin Inc., Wilmington, Del./USA(3) | 100.0 | 746 | 53 | 1,202 | 3,714 |
Berlex Canada Inc., Lachine/Canada | 100.0 | 12 | 4 | 66 | 214 |
Latin America | | | | | |
Schering Argentina S.A.I.C., Buenos Aires/Argentina | 100.0 | 13 | 6 | 47 | 212 |
Schering do Brasil Ltda., São Paulo/Brazil | 100.0 | 43 | 3 | 118 | 743 |
Schering Colombiana S.A., Bogotá/Colombia | 100.0 | 25 | 6 | 62 | 310 |
Schering Mexicana S.A., Mexico City/Mexico | 100.0 | 41 | 8 | 75 | 254 |
Asia/Australia | | | | | |
P.T. Schering Indonesia, Jakarta/Indonesia | 85.0 | 8 | 1 | 18 | 355 |
Nihon Schering K.K., Osaka/Japan | 100.0 | 139 | 16 | 497 | 1,560 |
Schering Pty. Ltd., Sydney/Australia | 100.0 | 18 | 5 | 77 | 117 |
Schering (Korea) Ltd., Seoul/Korea | 100.0 | 23 | 2 | 58 | 263 |
Schering (Bangkok) Ltd., Bangkok/Thailand(3) | 100.0 | 6 | 1 | 17 | 123 |
Africa | | | | | |
Schering (Pty.) Ltd., Midrand/South Africa | 100.0 | 10 | (1) | 30 | 100 |
(1) In the case of companies outside the euro zone, equity and annual results were translated from local currency amounts into € at the exchange rate in effect on December 31, 2003. Sales were translated into € at the annual average rate of exchange. (2) Most of the sales of Schering AG stem from the sales to subsidiaries; these sales are not included in the consolidated financial statements. (3) Figures include consolidated subsidiaries. |
(35) Emoluments of the Supervisory Board and the Executive Board; loans granted
The total remuneration of the members of the Supervisory Board amounted to €3,092 thousand and is composed as follows:
| Fixed compensation | Variable compensation | Committee functions |
---|
| € thousand | € thousand | € thousand |
---|
Dr. Giuseppe Vita (Chairman) | 7 | 298 | 76 |
Other members of the Supervisory Board | 51 | 2,267 | 393 |
| 58 | 2,565 | 469 |
A member of the Supervisory Board has received an annual fee for consultancy services [see section "Related Party Transactions"].
The total remuneration of the members of the Executive Board amounted to €11,164 thousand and is composed as follows:
| Fixed compensation | Variable compensation | Exercise LTI Plan 2000 |
---|
| € thousand | € thousand | € thousand |
---|
Dr. Hubertus Erlen (Chairman) | 544 | 1,638 | — |
Other members of the Executive Board | 2,150 | 6,716 | 116 |
| 2,694 | 8,354 | 116 |
A provision of €22,923 thousand has been recognized for the pensions of former members of the Executive Board and their dependents; the benefits paid for the year ended December 31, 2003 amounted to €1,967 thousand.
As part of the stock option plan set up in 2000, members of the Executive Board held non-transferable stock options on up to a maximum of 76,500 Schering AG shares as of December 31, 2003. These options may be exercised between 2003 and 2006. The exercise of the options depends on certain performance criteria relating to the Schering AG share price, which are determined under the provisions of the plans [see Notes (36) and (38)].
In addition, members of the Executive Board held 84,000 stock appreciation rights as part of the LTI Plan 2001/I (introduced in 2001), 100,000 stock appreciation rights as part of the LTI Plan 2001/II (introduced in 2002) and 120,000 stock appreciation rights as part of the LTI Plan 2001/III (introduced in 2003), which are subject to the fulfillment of certain conditions. These stock appreciation rights do not grant the right to acquire Schering AG shares, but rather the right to a cash settlement of the difference between the market price of Schering AG shares at the time of exercise and the exercise price [see Notes (36) and (38)].
The maximum number of shares (LTI Plan 2000) or stock appreciation rights (LTI Plans 2001/I through 2001/III) is as follows:
| LTI Plan 2000 | LTI Plan 2001/I | LTI Plan 2001/II | LTI Plan 2001/III |
---|
Dr. Hubertus Erlen (Chairman) | 22,500 | 20,000 | 20,000 | 20,000 |
Other members of the Executive Board | 54,000 | 64,000 | 80,000 | 100,000 |
| 76,500 | 84,000 | 100,000 | 120,000 |
As of December 31, 2003, a member of the Supervisory Board held non-transferable stock options for a maximum of 22,500 Schering AG shares, which were granted to him in his former capacity as a member of the Executive Board of Schering AG under the stock option plan set up in 2000.
As of December 31, 2003, a loan was granted to a member of the Supervisory Board [see section "Related Party Transactions"].
A directors’ and officers’ liability insurance policy (D&O) has been taken out. The deductible is €25 thousand for members of the Supervisory Board and €50 thousand for members of the Executive Board.
(36) Stock option plans
In 1998, 2000, and 2001, Schering AG introduced stock option plans (“Long Term Incentive Plans” or “LTI Plans”). Participants in the LTI Plans 1998 and 2000 who invested in Schering AG shares received options entitling them to subscribe for additional Schering AG shares free of charge. The number of options granted depended on the number of shares purchased: for every 18 shares, participants received one option entitling them to receive up to a maximum of 180 shares. The options can be exercised during the exercise period provided that the participants still hold the original shares at the beginning of this period. The number of shares that can be subscribed depends on the performance of Schering AG shares in absolute terms (performance) and compared with a benchmark index (outperformance). The performance e xercise hurdle for members of the Executive Board is 20% under the LTI Plan 1998 and 30% under the LTI Plan 2000.
The first tranche of the LTI Plan 2001 (LTI Plan 2001/I) was introduced in 2001, the second tranche (LTI Plan 2001/II) was introduced in 2002 and the third tranche (LTI Plan 2001/III) was introduced in 2003. All three tranches distinguish between two groups of beneficiaries: “Top Executives” and “Key Managers”. “Top Executives” participating in the LTI Plans 2001/I, 2001/II and 2001/III invested in Schering AG shares and received stock appreciation rights. Upon exercise of these rights, beneficiaries receive a cash payout in the amount of the difference between the defined strike price and the price of the Schering AG share on the exercise date. The strike price for “Top Executives” was fixed at the share price at the date of grant of the options (LTI Plan 2001/I: €54.66; LTI Plan 20 01/II: €66.48; LTI Plan 2001/III: €40.18). For these beneficiaries, exercise of the options is tied either to a 30% increase in the price of Schering AG shares or to the performance of the shares against a benchmark index (outperformance).
“Key Managers” participating in the LTI Plans 2001/I and 2001/II were granted options entitling them to subscribe for shares when the options are exercised. “Key Managers” participating in the LTI Plan 2001/III received stock appreciation rights. The strike price of the “Key Managers” options was fixed at 110% of the share price at the date of grant (LTI Plan 2001/I: €60.13; LTI Plan 2001/II: €73.13; LTI Plan 2001/III: €44.20). This group was not required to invest in Schering AG shares in order to participate, and exercise of the options is not tied to specific exercise hurdles.
The cost of the stock option plans is determined at each balance sheet date on the basis of the performance of Schering AG shares and the relevant benchmark index used, or by using valuation models. However, the costs of the LTI Plans 1998 and 2000 and 2001/III have been largely hedged by the purchase of Schering AG call options. A provision is recognized pro rata on the basis of these costs. The costs of the options under the LTI Plans 1998, 2000, 2001/I “Top Executives”, 2001/II “Top Executives”, 2001/III “Top Executives” and 2001/III “ Key Managers” are recognized as expenses. By contrast, no compensation expense is recognized for the “Key Managers” component of the LTI Plans 2001/I and 2001/II due to the conditions mentioned above, as these were designed as fixed stock optio n plans.
| LTI Plan 1998 | LTI Plan 2000 |
---|
Number of options outstanding as of January 1, 2003 | — | 4,777 |
Granted | — | — |
Forfeited in 2003 | — | — |
Exercised in 2003 | — | 1,937 |
Number of options outstanding as of December 31, 2003 | — | 2,840 |
Maximum number of award shares | — | 511,200 |
Exercise price per share (€) | — | 0 |
Compensation costs in 2003 (€m) | — | (2) |
Compensation costs in 2002 (€m) | 2 | 2 |
Benchmark index | DAX | STOXX Healthcare |
Date of grant | Jan. 1, 1998 | Jan. 1, 2000 |
Exercise period | Jan. 1, 2001 until Dec. 31, 2002 | Jan. 1, 2003 until Dec. 31, 2006 |
| LTI Plan 2001/I |
---|
| Top Executives | Key Managers |
---|
Number of options outstanding as of January 1, 2003 | 413,500 | 794,100 |
Granted | — | — |
Forfeited in 2003 | 7,000 | 29,700 |
Exercised in 2003 | — | — |
Number of options outstanding as of December 31, 2003 | 406,500 | 764,400 |
Maximum number of award shares | — | 764,400 |
Exercise price per share (€) | 54.66 | 60.13 |
Compensation costs in 2003 (€m) | 0 | — |
Compensation costs in 2002 (€m) | 0 | — |
Benchmark index | MSCI World Pharma&Biotech | — |
Date of grant | May 2, 2001 | May 2, 2001 |
Exercise period | May 2, 2004 until May 1, 2008 | May 2, 2004 until May 1, 2008 |
| LTI Plan 2001/II |
---|
| Top Executives | Key Managers |
---|
Number of options outstanding as of January 1, 2003 | 411,000 | 1,034,700 |
Granted | — | — |
Forfeited in 2003 | 13,000 | 33,900 |
Exercised in 2003 | — | — |
Number of options outstanding as of December 31, 2003 | 398,000 | 1,000,800 |
Maximum number of award shares | — | 1,000,800 |
Exercise price per share (€) | 66.48 | 73.13 |
Compensation in costs 2003 (€m) | 0 | — |
Compensation in costs 2002 (€m) | 0 | — |
Benchmark index | MSCI World Pharma&Biotech | — |
Date of grant | May 2, 2002 | May 2, 2002 |
Exercise period | May 2, 2005 until May 1, 2009 | May 2, 2005 until May 1, 2009 |
| LTI Plan 2001/III |
---|
| Top Executives | Key Managers |
---|
Number of options outstanding as of January 1, 2003 | 0 | 0 |
Granted | 420,700 | 1,173,000 |
Forfeited in 2003 | 3,000 | 12,600 |
Exercised in 2003 | — | — |
Number of options outstanding as of December 31, 2003 | 417,700 | 1,160,400 |
Maximum number of award shares | — | — |
Exercise price per share (€) | 40.18 | 44.20 |
Compensation in costs 2003 (€m) | 1 | 3 |
Benchmark index | MSCI World Pharma&Biotech | — |
Date of grant | May 2, 2003 | May 2, 2003 |
Exercise period | May 2, 2006 until May 1, 2010 | May 2, 2006 until May 1, 2010 |
F. SIGNIFICANT DIFFERENCES BETWEEN IFRS AND UNITED STATES GENERALLY ACCEPTED ACCOUNTING PRINCIPLES (U.S. GAAP)
(37) Reconciliation to U.S. GAAP
The Group’s consolidated financial statements have been prepared in accordance with International Financial Reporting Standards (IFRS), which, as applied by the Group, differ in certain material respects from U.S. GAAP. The effects of the application of U.S. GAAP to net profit and shareholders’ equity are set out in the tables below:
Reconciliation of Net Profit to U.S. GAAP (in € Millions Except per Share Data)
| Note | 2003 | 2002 | 2001 |
---|
Net profit under IFRS | | 443 | 867 | 418 |
U.S. GAAP adjustments | | | | |
Business combinations | | | | |
- Acquired in-process R&D | (a) | 14 | (119) | (12) |
- Other differences | (a) | 15 | 13 | (8) |
Property, plant and equipment | | | | |
- Capitalization of interest | (b) | (1) | (1) | (2) |
- Reversal of impairment losses | (b) | 0 | 1 | (2) |
Internal-use software | (c) | — | (3) | (3) |
Equity investment (Aventis CropScience) | (d) | — | 71 | 8 |
Inventories | (e) | 4 | 6 | (5) |
Provisions for pensions | (f) | 2 | 2 | 1 |
Other provisions | (g) | 15 | (2) | (5) |
Treasury Shares/ Schering AG call options | (h) | — | — | — |
Stock option plans | (i) | 3 | 14 | 3 |
Cash flow hedges | (j) | — | — | (11) |
Tax effect on U.S. GAAP adjustments | (k) | (6) | (1) | 21 |
Net profit under U.S. GAAP | | 489 | 848 | 403 |
Earnings per share under U.S. GAAP | | | | |
- basic (€) | | 2.52 | 4.30 | 2.04 |
- diluted (€) | | 2.51 | 4.29 | 2.03 |
Reconciliation of shareholders' equity to U.S. GAAP (in € millions)
| Note | 2003 | 2002 | 2001 |
---|
Shareholders' equity under IFRS | | 2,902 | 2,934 | 2,556 |
U.S. GAAP adjustments | | | | |
Business combinations | | | | |
- Acquired in-process R&D | (a) | (141) | (175) | (83) |
- Other differences | (a) | 42 | 28 | 16 |
Property, plant and equipment | | | | |
- Capitalization of interest | (b) | 16 | 17 | 18 |
- Reversal of impairment losses | (b) | (3) | (3) | (4) |
Internal-use software | (c) | — | — | 3 |
Equity investment (Aventis CropScience) | (d) | — | — | (71) |
Inventories | (e) | 22 | 18 | 12 |
Provisions for pensions | (f) | (33) | (54) | (1) |
Other provisions | (g) | 18 | 3 | 5 |
Treasury shares/ Schering AG call options | (h) | (7) | (10) | (11) |
Stock option plans | (i) | 22 | 34 | 35 |
Cash flow hedges | (j) | — | — | — |
Tax effect on U.S. GAAP adjustments | (k) | (11) | 2 | (18) |
Shareholders' equity under U.S. GAAP | | 2,827 | 2,794 | 2,457 |
a.) Business combinations
Under IFRS, acquired in-process R&D is not identified as an acquired asset in connection with the allocation of the purchase price, but rather capitalized as goodwill and amortized over its expected useful life. U.S. GAAP requires the identification of acquired in-process R&D as a separate component of the purchase price allocation. The ascertained amounts must be charged as expenses at the time of the acquisition. In addition, certain identifiable intangible assets recognized under U.S. GAAP are included in goodwill under IFRS. The adjustments relate to the acquisitions of Medrad Group (1995), Leiras (1996), Jenapharm Group (1996: 74.9%; 2001: 25.1%), Diatide (1999), and Collateral Therapeutics (2002). With regard to our acquisition of Collateral Therapeutics, the difference between the purchase price and net assets ac quired was identified as in-process R&D and expensed in the amount of €131m under U.S. GAAP. In determining the cost of the acquisition, securities issued by the acquirer are measured at their fair value at the date of the exchange transaction under IFRS. Under U.S. GAAP, the purchase price determination is based on the market price of the securities over a reasonable period of time before and after the date that the terms of the acquisition are agreed to and announced, thereby resulting in an increase in the purchase price of €18m for the acquisition of Collateral Therapeutics compared with IFRS.
Under U.S. GAAP, the negative goodwill arising on the acquisition of CIS bio international is deducted proportionately from non-current assets, excluding securities.
In fiscal 2001, amortization charges amounting to €35m were included in net profit under U.S. GAAP.
In contrast to IFRS, goodwill arising from acquisitions is not amortized under U.S. GAAP with effect from January 1, 2002. Acquired goodwill is allocated to reporting units and tested annually for impairment. The most recent fair value determination in 2002, which was based on the present value of estimated future cash flows, resulted in an amount that exceeded the carrying amount of the corresponding reporting unit by a substantial margin. The assets and liabilities that make up the reporting unit have not changed significantly since the most recent fair value determination in 2002. Based on an analysis of events that have occurred and circumstances that have changed since the most recent fair value determination in 2002, the likelihood that a current fair value determination would be less than the current carrying amount of t he reporting unit is remote. Accordingly, no goodwill was written down for impairment in 2003.
b.) Property, plant and equipment
The Group does not capitalize interest costs on self-constructed assets under IFRS. Under U.S. GAAP, interest costs incurred during the construction period must be capitalized and amortized. Interest of €3m (2002: €4m; 2001: €4m) was capitalized under U.S. GAAP. Total capitalized interest under U.S. GAAP as of December 31, 2003 was €16m (2002: €17m; 2001: €18m). The reduction relates to depreciation.
Under IFRS, impairments of fixed assets at our production plant in Bergkamen have been reversed during fiscal 2000 and 2001. Impairment losses cannot be reversed under U.S. GAAP.
c.) Internal-use software
As of January 1, 1999, we adopted Statement of Position (SOP) 98-1 “Accounting for the Costs of Computer Software Developed or Obtained for Internal Use” under U.S. GAAP. This statement requires the capitalization of certain costs incurred in the development of software for internal use, including payroll and payroll-related costs. Under IFRS, these costs are capitalized starting on January 1, 2000. The reconciliation item relates to costs for the year 1999, which were capitalized under U.S. GAAP, but expensed under IFRS.
d.) Equity investment (Aventis CropScience)
The application of U.S. GAAP in the consolidated financial statements of Aventis CropScience reduced the carrying amount of our equity investment. The most significant differences related to acquired in-process R&D from certain prior AgrEvo acquisitions and the timing of recognition and use of restructuring provisions in connection with the merger of the agribusiness of AgrEvo and Rhône-Poulenc Agro. The investment was disposed of at the beginning of June 2002. Due to the lower book value under U.S. GAAP, the sale of our investment in 2002 resulted in a higher profit.
e.) Inventories
Under IFRS, the allocation of fixed production overheads to the cost of inventories is based on the normal capacity of the production facilities. Idle facility expenses are treated as a current period charge. Under U.S. GAAP, idle facility expenses are allocated between cost of sales and inventories.
f.) Provisions for pensions
Under U.S. GAAP, pension costs and similar obligations are accounted for in accordance with Statement of Financial Accounting Standards (SFAS) No. 87 “Employers’ Accounting for Pensions”. Companies located outside the U.S. were required to adopt the provisions of SFAS No. 87 for the first time for fiscal years beginning on or after December 15, 1988. Due to the long period of time between the effective date and the time when the Group first prepared U.S. GAAP information, adoption of the provisions of SFAS No. 87 as of January 1, 1989 was not feasible. The Group adopted SFAS No. 87 as of January 1, 1998 and recognized a transition obligation of €13m. On January 1, 1998, the average remaining service period of active employees was 20 years. An amount of €6m was deducted directly from equity (for the peri od 1989 to 1997). €1m (5% of the transition obligation) will be recognized in income each year through 2008.
The amortization of actuarial gains/losses [see Note (24)] is partly related to the first-time application of IAS 19 “Employee Benefits (revised)” in 1999. This requires amortization amounting to €3m (2002: €3m) to be eliminated in the reconciliation.
Where the Accumulated Benefit Obligation (ABO) exceeds the fair value of plan assets at the measurement date, SFAS No. 87 requires the recognition of a minimum pension liability equaling the underfunding. In 2003, an additional liability amounting to €36m (2002: €54m) was therefore recognized under U.S. GAAP to reflect the difference between the pension liabilities already accrued and the minimum pension liability. A corresponding contra item amounting to €22m after deferred taxes (2002: €33m after deferred taxes) has been directly recognized as Accumulated other comprehensive income in 2003.
g.) Other provisions
The reconciliation item relates almost exclusively to liabilities arising from our early retirement program, under which an employee older than 54 is offered the opportunity to work half-time for up to six years for 85% of pay. Under IFRS, the (discounted) incremental costs are recognized in full once a binding contractual arrangement has been entered into. Under U.S. GAAP, such amounts are accrued over the employees’ remaining service period (on an undiscounted basis).
h.) Schering AG call options
Schering AG call options acquired to hedge the LTI 2000 stock option plan are recognized as an asset under IFRS. Under U.S. GAAP, the Schering AG call options are deducted from equity.
i.) Stock option plans
Refer to Note (36) of the consolidated financial statements for a description of our stock option plans. Under U.S. GAAP, we make use of Accounting Principles Board Opinion (APB) No. 25 “Accounting for Stock Issued to Employees” and provide additional disclosures in Note (38) as required by SFAS No. 123 “Accounting for Stock Based Compensation”.
LTI Plan 1998 and LTI Plan 2000:
The LTI 1998 and LTI 2000 stock option plans are variable award plans. Compensation costs under IFRS are measured on the basis of the estimated performance of the Schering AG share price and the performance of a benchmark index (DAX and STOXX Healthcare). The costs of the LTI Plans 1998 and 2000 have been largely hedged by the purchase of Schering AG call options. Under U.S. GAAP, compensation costs are recognized over the three-year vesting period on the basis of the fair value of Schering AG shares and the benchmark index at the respective balance sheet dates. Under U.S. GAAP, the acquisition costs of the Schering AG call options are deducted from equity, and the proceeds from the sale of the options are credited directly to equity. Under IFRS, the accumulated compensation costs are shown as a liability. Under U.S. GAAP, thes e costs are part of equity.
LTI Plan 2001:
Both LTI Plan 2001/I “Top Executives” and LTI Plan 2001/II “Top Executives” are variable award plans. Compensation costs under IFRS are measured on the basis of an estimate of the outcome of the performance conditions at each balance sheet date by utilizing option pricing models. Under U.S. GAAP, compensation costs are measured at the fair value of Schering AG shares at the respective balance sheet dates. The plans are designed as stock appreciation right plans. At exercise, the award will be settled by a cash payment amounting to the difference between the market price of Schering AG shares at the date of exercise and the exercise price. Compensation costs are therefore accrued as a liability under both IFRS as well as under U.S. GAAP.
j.) Cash flow hedges
Prior to January 1, 2001, gains and losses from currency hedging of anticipated sales and expenses were deferred under IFRS by applying hedge accounting. Accordingly, we recognized gains of €11m in 2001 (net of tax: €7m) relating to 2000 hedging contracts, since these gains are related to sales and expenses realized in 2001. No hedge accounting was applied under U.S. GAAP.
As of January 1, 2001, we adopted SFAS No. 133 “Accounting for Derivative Instruments and Hedging Activities” under U.S. GAAP and IAS 39 "Financial Instruments: Recognition and Measurement" under IFRS. Hedging of anticipated sales and expenses is now accounted for as a cash flow hedge under U.S. GAAP and IFRS.
k.) Tax effect on U.S. GAAP adjustments
This reconciliation item includes all tax effects due to the aforementioned reconciling items, except the adjustment relating to the equity method (Aventis CropScience), which is presented net of tax.
(38) Additional U.S. GAAP information
SFAS No. 130 "Reporting Comprehensive Income"
SFAS No. 130 “Reporting Comprehensive Income” requires the reporting of all changes in shareholders’ equity except those resulting from investments by or distributions to shareholders.
Statement of comprehensive income for the years ended December 31
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
U.S. GAAP net profit [see Note (37)] | 489 | 848 | 403 |
Currency translation adjustments | | | |
IFRS accounts | (194) | (234) | 7 |
Reconciliation to U.S. GAAP | 19 | 8 | — |
Available-for-sale securities | | | |
Unrealized gains and losses (after deferred taxes of €(4)m; 2002: €14m; 2001: €16m) | 5 | (45) | (59) |
Less realized (gains) and losses recognized in net profit (after tax expense of €5m; 2002: €(4)m; 2001: €2m) | (7) | 21 | (2) |
Less (gains) and losses resulting from currency translation adjustments (after deferred taxes of €0m; 2002: 1m) | 0 | (1) | — |
Cash flow hedges | | | |
Unrealized gains and losses (after deferred taxes of €(20)m; 2002: €(27)m; 2001: €(3)m) | 31 | 41 | 5 |
Less realized (gains) and losses recognized in net profit (after tax expense of €26m; 2002: €14m; 2001: €1m) | (40) | (21) | (1) |
Minimum pension liability (after deferred taxes of €(7)m; 2002: €21m) | 11 | (33) | — |
Other comprehensive income, net of tax | (175) | (264) | (50) |
Comprehensive income, net of tax | 314 | 584 | 353 |
Accumulated other comprehensive income balances as of December 31
| Currency translation adjustment | Available- for-sale securities | Derivative hedging instruments | Minimum pension liability | Accumulated other com- prehensive income |
---|
| €m | €m | €m | €m | €m |
---|
January 1, 2001 | 91 | 89 | — | — | 180 |
Other comprehensive income 2001 | 7 | (61) | 4 | — | (50) |
December 31, 2001 | 98 | 28 | 4 | — | 130 |
Other comprehensive income 2002 | (226) | (25) | 20 | (33) | (264) |
December 31, 2002 | (128) | 3 | 24 | (33) | (134) |
Other comprehensive income 2003 | (175) | (2) | (9) | 11 | (175) |
December 31, 2003 | (303) | 1 | 15 | (22) | (309) |
Statement of U.S. GAAP shareholders’ equity as of December 31
| 2003 | 2002 | 2001 |
---|
| €m | €m | €m |
---|
Equity according to U.S. GAAP before Accumulated other comprehensive income | 3,136 | 2,928 | 2,327 |
Accumulated other comprehensive income | (309) | (134) | 130 |
Total equity according to U.S. GAAP | 2,827 | 2,794 | 2,457 |
Available-for-sale securities:
| Book value | Gross unrealized gains | Gross unrealized losses | Fair value |
---|
As of December 31, 2003 | €m | €m | €m | €m |
Investments (non-current) | 18 | 0 | — | 18 |
Marketable securities | 173 | 1 | — | 173 |
| 191 | 1 | — | 191 |
As of December 31, 2002 | | | | |
Investments (non-current) | 25 | 2 | 5 | 25 |
Marketable securities | 249 | 6 | — | 249 |
| 274 | 8 | 5 | 274 |
As of December 31, 2001 | | | | |
Investments (non-current) | 69 | 30 | — | 69 |
Marketable securities | 103 | 3 | — | 103 |
| 172 | 33 | — | 172 |
Proceeds from sales of available-for-sale securities in 2003 amounted to €160m (2002: €31m, 2001: €144m). Gross Gains of €14m and gross losses of €3m were realized on the sale of such securities in 2003. Gross gains in 2002 as well as gross losses in 2002 and 2001 on such sales were immaterial. Gross gains of €17m were realized on the sale of securities in 2001. In 2003, impairment losses of €7m were recognized (2002: €26m; 2001: €44m). In December 2001, securities with a fair value of €250m were transferred to the Schering Pension Trust, thereby realizing a gain of €35m.
Maturities of fixed-term marketable securities as of December 31, 2003 are as follows:
| Book value | Market value |
---|
| €m | €m |
---|
Less than 1 year | 0 | 0 |
Between 1 and 5 years | 0 | 0 |
More than 5 years | 2 | 2 |
As of December 31, 2003, the Group also held an investment in a fixed-income fund of €155m (2002: €185m).
Impairment of long-lived assets
The Group periodically evaluates the carrying amount of long-lived assets to be held and used, including goodwill and other intangible assets, when events and circumstances warrant such a review. Under U.S. GAAP, the carrying amount of a long-lived asset is considered impaired when the anticipated undiscounted and probability-weighted cash flow from such an asset is separately identifiable and is less than its carrying amount. In such event, a loss is recognized based on the amount by which the carrying amount exceeds the fair value of the long-lived asset. Fair value is determined primarily using anticipated cash flows discounted at a rate commensurate with the risk involved. As of December 31, 2003, 2002 and 2001, there was no reconciliation item arising from different policies for recognizing impairment of long-lived assets under IFRS and U.S. GAAP.
Corporate debt
At December 31, 2003, the Schering AG Group had aggregate unused committed lines of credit of €81m (December 31, 2002: €192m).
Employee benefit plans
The information required by SFAS No. 132 (revised 2003) “Employers` Disclosures about Pensions and Other Postretirement Benefits” is included in Note (4) and Note (24) to the consolidated financial statements.
Pension obligations and expenses determined under SFAS No. 87 were based on the same assumptions as under IFRS [see Note (4)].
Under IFRS, interest relating to the pension obligations not transferred to external funds is presented in the Financial result [see Note (9)]. Under U.S. GAAP, interest on pension obligations is considered a component of compensation expenses. Accordingly, Operating profit under U.S. GAAP would be lower and the Financial result higher by €35m (2002: €44m; 2001: €76m).
Stock option plans
In electing to continue to follow APB No. 25 for expense recognition purposes, we are obliged to provide additional disclosures required under SFAS No. 123.
LTI Plans 1998 and 2000:
The fair value of one option for the LTI Plan 1998 at the date of grant (January 1, 1998) was €2,408 (€10m for all options).The fair value of one option for the LTI Plan 2000 at the date of grant (January 1, 2000) was €6,374 (€32m for all options). Both calculations were based on a Monte Carlo simulation.
LTI Plan 2001/I:
The fair value of one option for the LTI Plan 2001/I “Top Executives” at the date of grant (May 2, 2001) was €15.37 (€6m for all options). The fair value of one option for the LTI Plan 2001/I “Key Managers” at the date of grant (May 2, 2001) was €13.34 (€11m for all options). Both calculations were based on a Black-Scholes option pricing model using the following assumptions:
Expected life | 5 years |
Dividend yield | 1.2% |
Risk-free interest rate | 4.8% |
Volatility | 25% |
LTI Plan 2001/II:
The fair value of one option for the LTI Plan 2001/II “Top Executives” at the date of grant (May 2, 2002) was €19.15 (€8m for all options). The fair value of one option for the LTI Plan 2002/II “Key Managers” at the date of grant (May 2, 2002) was €16.73 (€17m for all options). Both calculations were based on a Black-Scholes option pricing model using the following assumptions:
Expected life | 5 years |
Dividend yield | 1.2% |
Risk-free interest rate | 4.75% |
Volatility | 27.2% |
LTI Plan 2001/III:
The fair value of one option for the LTI Plan 2001/III “Top Executives” at the date of grant (May 2, 2003) was €12.25 (€5m for all options). The fair value of one option for the LTI Plan 2001/III “Key Managers” at the date of grant (May 2, 2003) was €11.10 (€13m for all options). Both calculations were based on a Black-Scholes option pricing model using the following assumptions:
Expected life | 5 years |
Dividend yield | 2.3% |
Risk-free interest rate | 3.21% |
Volatility | 37.7% |
The pro forma information, prepared in accordance with the provisions of SFAS No. 123, as amended by SFAS No. 148, is as follows:
| 2003 | 2002 | 2001 |
---|
Net profit, as reported (U.S. GAAP) | 489 | 848 | 403 |
Add: Stock-based employee compensation expense determined under APB No. 25 | 0 | (10) | 16 |
Deduct: Stock-based employee compensation expense determined under SFAS No. 123 | (14) | (22) | (43) |
Pro forma net profit (U.S. GAAP) | 475 | 816 | 376 |
Earnings per share (basic): | | | |
- as reported (€) | 2.52 | 4.30 | 2.04 |
- pro forma (€) | 2.44 | 4.14 | 1.90 |
Earnings per share (diluted): | | | |
- as reported (€) | 2.51 | 4.29 | 2.03 |
- pro forma (€) | 2.44 | 4.12 | 1.89 |
Intangible assets
Expected amortization on intangible assets, excluding amortization on goodwill:
| IFRS | U.S. GAAP |
---|
| €m | €m |
---|
2004 | 78 | 98 |
2005 | 72 | 89 |
2006 | 60 | 69 |
2007 | 55 | 63 |
2008 | 46 | 53 |
Goodwill
Allocation of goodwill to the primary segments:
| IFRS | U.S. GAAP |
---|
| 2003 | 2002 | 2003 | 2002 |
---|
| €m | €m | €m | €m |
---|
Europe Region | 271 | 313 | 147 | 148 |
United States Region | 75 | 101 | 40 | 46 |
Japan Region | 12 | 17 | 5 | 6 |
Latin America/Canada Region | 4 | 5 | 0 | 0 |
Asia/Middle East Region | 4 | 4 | 3 | 2 |
Other Activities | 0 | 0 | 0 | 0 |
| 366 | 440 | 195 | 202 |
Under IFRS, acquired in-process R&D is capitalized as goodwill. U.S. GAAP requires such amounts to be charged as expenses at the time of the acquisition. In addition, certain identifiable intangible assets recognized under U.S. GAAP are included in goodwill under IFRS.
The change in goodwill reported under U.S. GAAP between 2002 and 2003 is related to currency translation adjustments as well as to an addition to our segment Asia/Middle East Region amounting to €2m.
Effective January 1, 2002, goodwill is no longer amortized in accordance with SFAS No. 142. If the standard had been applied already in 2001, net profit and earnings per share would have been as follows:
| 2003 | 2002 | 2001 |
---|
Net profit, as reported (U.S.GAAP) | €489m | €848m | €403m |
Goodwill amortization | — | — | €35m |
Net profit, adjusted (U.S. GAAP) | €489m | €848m | €438m |
Earnings per share (basic), as reported | €2.52 | €4.30 | €2.04 |
Goodwill amortization | — | — | €0.18 |
Earnings per share (basic), adjusted | €2.52 | €4.30 | €2.22 |
Earnings per share (diluted), as reported | €2.51 | €4.29 | €2.03 |
Goodwill amortization | — | — | €0.18 |
Earnings per share (diluted), adjusted | €2.51 | €4.29 | €2.21 |
Legal proceedings
The Group is involved in a number of legal proceedings and claims incidental to the normal conduct of its business, relating to such matters as product liability, patent infringement, tax assessments, competition, past waste disposal practices and the release of chemicals into the environment. Although the outcome of these proceedings and claims cannot be predicted with certainty, Schering AG believes that any resulting liabilities, net of amounts recoverable from insurance or otherwise, will not, in the aggregate, have a material adverse effect on the Group’s consolidated results of operations, financial condition and cash flows. To the extent that these legal proceedings and claims meet the criteria laid down in SFAS No. 5 “Accounting for Contingencies”, provisions have been set up for them in the consolidated financial statements.
Schering AG has always assumed certain liabilities for ecological and other risks in connection with the sale of business areas. The warranty assumed in 1992 in relation to the sales of our Industrial Chemicals and Natural Substances division expires in 2004.
What we believe to be the most significant of the proceedings and claims are described below.
The Group's Brazilian subsidiary is a defendant in approximately 460 civil actions brought in courts in Brazil by women, suing individually and claiming, that they became unintentionally pregnant. Most of them claim that they became unintentionally pregnant after taking placebo pills packaged by the subsidiary in connection with test runs of a new packaging machine between January and April 1998. Most of these claims are still pending. In the majority of the judgments obtained to date, the claims were rejected by the Brazilian courts. In connection with this incident, two managers of the Group's Brazilian subsidiary were convicted in a Brazilian court for the failure to label properly the pouches and blisters for the placebo pills. The Brazilian court imposed a minor fine.
In November 1998, Medrad, Inc., one of the Group’s subsidiaries in the United States, was sued by Liebel-Flarsheim, Inc. which alleged patent infringement, antitrust violations and tortious interference with contractual relations. In October 2001 and February 2002, the U.S. District Court for the Southern District of Ohio, on summary judgement motions, decided in favor of Medrad regarding Liebel-Flarsheim’s patent infringement claims. Liebel-Flarsheim appealed the decision of the U.S. District Court and the Federal Circuit Court of Appeals reversed the District Court’s decision and remanded it back to the District Court in February 2004. All claims other than the patent claims were withdrawn by Liebel-Flarsheim in connection with a settlement reached in October 2002.
The Group’s subsidiary in the United States, Berlex Inc., was named as a defendant with 30 other pharmaceutical companies in cases filed by Suffolk County and Westchester County, New York, in January and August 2003, respectively. The two lawsuits contain virtually identical allegations that pharmaceutical companies have overcharged both counties for prescription medications paid for by New York State’s Medicaid program by reporting artificially inflated “average wholesale prices” for their drug products for the purpose of government reimbursement. Both counties seek a variety of unspecified damages from the various pharmaceutical companies. The cases have been consolidated into a multidistrict litigation in the District of Massachusetts In Re Pharmaceutical Industry Average Wholesale Price Litigation (MDL 1 456). Berlex intends to vigorously defend itself against the allegations made in the lawsuit, and a dismissal motion is currently pending.
Following the sale of Schering’s share in Aventis CropScience to Bayer AG, Bayer CropScience has initiated arbitration proceedings alleging the violation of a financial statement guarantee for which Bayer CropScience demands payments of damages. It cannot be reasonably estimated at the date of this report whether the underlying facts justify such a claim and , if so, to what extent the Group would be liable. Bayer CropScience has further notified Schering AG in several other cases about potential violations of provisions of the Aventis CropScience Stock Purchase Agreement which might lead to damages. Also with respect to these claims it cannot be estimated whether and to what extent the Group would be liable.
A U.S. citizen has filed an action against Schering AG and Bayer AG with a New York court. The plaintiff claims damages for forced sterilization and cruel treatment suffered at the Auschwitz concentration camp during World War II. To our knowledge and belief, there is no factual information suggesting that Schering AG could in any way have been involved in what was done to the plaintiff. Schering AG also believes that the claim cannot be made against an individual company but should be directed to the “Remembrance, Responsibility and the Future” Foundation. This foundation has been endowed with a capital of more than €5bn by German companies (including Schering AG) and the German Federal Government. The beneficiaries of compensation grants paid by the foundation include victims of human experiments in concentrati on camps. Schering AG considers the claims asserted to be unjustified and expects that the action will be dismissed.
Dividends
Under the German Commercial Code (HGB), dividends can be paid only from the unappropriated profit of the parent company, Schering AG. At December 31, 2003, the profit of Schering AG totaled €223m, resulting from 2003 net profit of €442m, less a transfer of €221m to Retained earnings, as determined by the Executive Board and the Supervisory Board, and an additional €2m profit brought forward from 2002.
Related Party Transactions
Shareholders: Allianz Versicherungs-AG currently provides insurance services to the Schering AG Group in a number of different areas such as property, business interruption, directors’ and officers’ liability, marine, personal accident and automobile insurance. Deutsche Bank AG provides us with a variety of financial services in the ordinary course of business. We believe that these services are provided on an arm’s length basis.
Directors: Certain members of the Supervisory and Executive Boards are members of the supervisory boards of various financial institutions with which we engage in transactions in the ordinary course of business.
Professor John A. Dormandy, a member of the Supervisory Board, has provided consultancy services to Schering AG in connection with research relating to certain cardiovascular indications since June of 1996. For these services Professor Dormandy has received a fee of €56,242 plus expenses of €2,272 in 2003.
Professor Dr. Piet Borst and Professor John A. Dormandy are members of the Board of Governors of Schering Forschungsgesellschaft mbH, a wholly owned subsidiary of Schering AG. They received attendance fees in this capacity of €1,000 and €2,000 respectively in 2003.
There was a loan with a balance of €30 thousand to one member of the Supervisory Board as of December 31, 2003 (repayments in 2003 amounted to €3 thousand). Interest of 6% is charged on the loan, which is repayable over 13 years. A loan previously granted to a member of the Executive Board was redeemed completely during the reporting period. All such loans have been granted prior to July 29, 2002 and have not been amended or extended since then.
According to section 15a of the German Securities Trading Act (”Wertpapierhandelsgesetz”), the members of the Executive or the Supervisory Board of Schering AG have to notify transactions in securities of their own company. This applies to transactions whose aggregate value terms of the total number of transactions carried out by the party subject to the disclosure requirement within 30 days exceeds €25 thousand. The same obligation applies to transactions of close relatives. During fiscal year 2003, Schering AG has been notified of a total of 12 transactions. In accordance with section 15a of the German Securities Trading Act, Schering AG has promptly disclosed these transactions on its web site. Members of the Supervisory Board and their relatives have purchased 5,000 Schering AG shares and have sold 1,000 shar es. The same group has purchased 9,500 call options on Schering AG shares and has sold the same amount. Members of the Executive Board and their relatives have purchased 6,000 shares and have sold 2,700 call options. A complete list with all details of the notified transactions is available in the data bases of the German Federal Authority for Financial Services Supervision (Bundesanstalt für Finanzdienstleistungsaufsicht) under www.bafin.de.
New Accounting Standards under U.S. GAAP
We have applied SFAS No. 141 “Business Combinations” and SFAS No. 142 “Goodwill and Other Intangible Assets” since January 1, 2002. SFAS No. 141 requires the use of the purchase method of accounting for all business combinations. In addition, it establishes criteria for the separate recognition of intangible assets from goodwill.
Under SFAS No. 142, goodwill and intangibles with indefinite lives are no longer subject to amortization, but must be tested for impairment annually using a defined procedure, resulting in the recognition of an impairment loss if appropriate. In fiscal 2001, goodwill amortization charges amounting to €35m were included in net profit under U.S. GAAP. Impairment testing of goodwill from earlier acquisitions performed in 2002 did not result in any impairment losses. Impairment testing was performed on the basis of the present value of estimated future cash flows. In addition, the estimated remaining useful lives of existing intangible assets were reviewed effective January 1, 2002 and, where necessary, their amortization periods adjusted to reflect the changes in their remaining useful lives.
In June 2001, the Financial Accounting Standards Board issued SFAS No. 143 “Accounting for Asset Retirement Obligations”. This Statement addresses financial accounting and reporting for obligations associated with the retirement of tangible long-lived assets and the associated asset retirement costs. SFAS No. 143 is effective for fiscal years beginning after June 15, 2002. The application of SFAS No. 143 did not materially impact our U.S. GAAP reconciliation.
In August 2001, the Financial Accounting Standards Board issued SFAS No. 144 “Accounting for the Impairment or Disposal of Long-lived Assets”. This Statement addresses financial accounting and reporting for the impairment or disposal of long-lived assets. SFAS No. 144 is effective for fiscal years beginning after December 15, 2001. The application of this Standard had no impact on our U.S. GAAP reconciliation.
In July 2002, the Financial Accounting Standards Board issued SFAS No. 146 “Accounting for Costs Associated with Exit or Disposal Activities”, which nullifies Emerging Issues Task Force (EITF) Issue No. 94-3, “Liability Recognition for Certain Employee Termination Benefits and Other Costs to Exit an Activity (including Certain Costs Incurred in a Restructuring)”. SFAS No. 146 requires that a liability associated with the exit or disposal of activities be recognized only when the liability is incurred, and not when the entity concerned commits to an exit or disposal plan. SFAS No. 146 is effective for all exit or disposal activities initiated after December 31, 2002. The application of this standard had no material impact on our U.S. GAAP reconciliation.
In December, 2002, the Financial Accounting Standards Board issued SFAS No. 148 “Accounting for Stock-Based Compensation –Transition and Disclosure”, which amends the disclosure requirements relating to stock-based employee compensation previously contained in SFAS No. 123. SFAS No. 148 is effective for all fiscal years ending after December 15, 2002. The disclosure requirements have been taken into account in the additional information provided on U.S. GAAP [see Note (38)].
On April 30, 2003, the Financial Accounting Standards Board issued SFAS No. 149 “Amendment of Statement 133 on Derivative Instruments and Hedging Activities”. This standard amends and clarifies financial accounting and reporting for derivative instruments, including certain derivative instruments, and derivative instruments embedded in other contracts, and for hedging activities. SFAS No. 149 is effective for contracts entered into or modified after June 30, 2003. The application of this standard had no material impact on our U.S. GAAP reconciliation.
On May 15, 2003, the Financial Accounting Standards Board issued SFAS No. 150 “Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity”. Under SFAS No. 150, certain financial instruments, previously classified as equity, are now required to be classified as liability by the issuer. SFAS No. 150 primarily affects accounting for financial instruments that embody an obligation to repurchase equity instruments that have been issued by the company. SFAS No. 150 is effective for transactions entered into or modified after May 31, 2003. The application of this standard had no impact on our U.S. GAAP reconciliation.
In December 2003, the Financial Accounting Standards Board issued SFAS No. 132 (revised 2003) “Employers’ Disclosures about Pensions and Other Postretirement Benefits”. SFAS No. 132 (revised 2003) is effective for fiscal years ending after December 15, 2003.The standard requires companies to provide more detailed disclosures about pensions and other postretirement benefit plans. Among other things, companies are required to describe investment policies and strategies and to provide a description of the basis used to determine the overall expected long-term rate-of-return-on-assets together with a classification of the plan assets by investment classes. The disclosures required are reported in Note (24).
Under SFAS No. 140 “Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities”, qualifying special purpose entities are exempted from consolidation under certain circumstances. In January 2003, the FASB published FIN No. 46 “Consolidation of Variable Interest Entities –an interpretation of ARB No. 51”, which clarifies the application of the consolidation rules to certain variable interest entities which do not qualify as qualifying special purpose entities. FIN No. 46 applies immediately for variable interest entities created after January 31, 2003. By issuing FASB Staff Position (FSP) FIN 46-6 “Effective Date of FASB`s Interpretation No. 46, Consolidation of Variable Interest Entities”, the Financial Accounting Standards Board deferred the effective date for initial application of FIN No. 46 for VIE`s created before February 1, 2003 to December 31, 2003. In December 2003, the FASB issued FIN 46 (revised December 2003). According to FIN 46 (revised December 2003), the provisions of FIN 46 or FIN 46 (revised December 2003) shall be applied to all variable interest entities no later than the end of the first reporting period that ends after March 31, 2004. Our U.S. GAAP reconciliation is not affected by the FASB rules, since we hold no investment that is classified as a qualifying special purpose entity or a variable interest entity.