Exact Sciences (EXAS) S-3ASR Automatic shelf registration

QuickLinks -- Click here to rapidly navigate through this document

Exhibit 12

Exact Sciences Corporation
Computation of Earnings to Fixed Charges
(in thousands)

				Fiscal Year Ended December 31
	Three Months Ended Mar 31 2015
				2014			2013			2012			2011			2010
Earnings:
Pre-tax income from continuing operation		(35,801	)		(100,048	)		(46,514	)		(52,421	)		(28,675	)		(11,556	)
Add: Fixed Charges	$	32		$	186		$	176		$	78		$	39		$	38
Earnings available for fixed charges	$	(35,769	)	$	(99,862	)	$	(46,338	)	$	(52,343	)	$	(28,636	)	$	(11,518	)
Fixed Charges:
Interest expensed and capitalized		11			51			69			41			21			20
Rental expense interest estimate		21			135			107			37			18			18
Total fixed charges	$	32		$	186		$	176		$	78		$	39		$	38
Deficiency of Earnings to Cover Fixed Charges		(35,801	)		(100,048	)		(46,514	)		(52,421	)		(28,675	)		(11,556	)
Ratio of Earnings to Fixed Charges			(1)			(1)			(1)			(1)			(1)			(1)

(1)

During each of these periods, our earnings were less than our fixed charges. The amount of the deficiency for each period is set forth in the above table under the caption "Deficiency of Earnings to Cover Fixed Charges.

QuickLinks

Exhibit 12

Exact Sciences Corporation Computation of Earnings to Fixed Charges (in thousands)