Confidential
Exhibit 10.49
Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin
This Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin, dated as of December 3, 2007 (“Effective Date”), is entered into by and between Patheon Italia S.p.A. (“Patheon”) and ZymoGenetics, Inc., a Washington corporation (“ZGEN”).
The parties hereby agree that the Manufacturing Services Agreement relating to rhThrombin, dated January 1, 2006 (the “Agreement”) shall be amended as follows:
1. | Territory |
Schedule H shall be replaced by the updated Schedule H attached hereto.
2. | Ratification of Agreement |
All other terms and obligations of the Agreement shall remain in full force and effect.
IN WITNESS WHEREOF, ZGEN and Patheon have executed this Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin as of the Effective Date.
Patheon Italia S.p.A. | ZymoGenetics, Inc. | |||
/s/ Aldo Braca | /s/ Vaughn B. Himes | |||
Aldo Braca | Vaughn B. Himes, Ph.D. | |||
Managing Director Patheon Italia S.p.A. – President Patheon Europe | Senior Vice President, Technical Operations | |||
Date: December 3, 2007 | Date: December 5, 2007 |
Confidential
SCHEDULE H
TERRITORY
United States of America
Countries within Europe
• Albania | • Andorra | • Armenia | ||
• Austria | • Azerbaijan | • Belarus | ||
• Belgium | • Bosnia and Herzegovina | • Bulgaria | ||
• Croatia | • Cyprus | • Czech Republic | ||
• Denmark | • Estonia | • Finland | ||
• France | • Georgia | • Germany | ||
• Greece | • Hungary | • Iceland | ||
• Ireland | • Italy | • Kazakhstan | ||
• Kyrgyzstan | • Latvia | • Liechtenstein | ||
• Lithuania | • Luxembourg | • Macedonia | ||
• Malta | • Moldova | • Monaco | ||
• Montenegro | • Netherlands | • Norway | ||
• Poland | • Portugal | • Romania | ||
• Russia | • San Marino | • Serbia | ||
• Slovakia | • Slovenia | • Spain | ||
• Sweden | • Switzerland | • Tajikistan | ||
• Turkey | • Turkmenistan | • Ukraine | ||
• United Kingdom | • Uzbekistan | • Vatican City |
Countries within Canada/Latin America Region
• Canada | • Mexico | • Argentina | ||
• Bolivia | • Brazil | • Chile | ||
• Colombia | • Dominican Republic | • Ecuador | ||
• El Salvador | • Guatemala | • Nicaragua | ||
• Paraguay | • Peru | • Uruguay | ||
• Venezuela | • Costa Rica | • Honduras | ||
• Panama | • Belize | • Cuba | ||
• French Guiana | • Guadeloupe | • Guyana | ||
• Haiti | • Suriname |
Countries within Asia/Pacific Region
• Australia | • Cambodia | • China | ||
• Hong Kong | • Indonesia | • India | ||
• Malaysia | • New Zealand | • Pakistan | ||
• Philippines | • Singapore | • South Korea | ||
• Vietnam | • Taiwan | • Thailand | ||
• Bahrain | • Bangladesh | • Bhutan | ||
• Brunei | • Israel | • Jordan | ||
• Kuwait | • Oman | • Qatar | ||
• Saudi Arabia | • United Arab Emirates |
Countries within Japan Region
• Japan |