Traws Pharma (TRAW) 10-Q 12 Aug 20 2020 Q2 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2020	Aug. 03, 2020
Document and Entity Information
Document Type	10-Q
Document Period End Date	Jun. 30, 2020
Entity Registrant Name	Onconova Therapeutics, Inc.
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		179,653,648
Entity Central Index Key	0001130598
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2020
Document Fiscal Period Focus	Q2
Amendment Flag	false

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($)	Jun. 30, 2020	Dec. 31, 2019
Current assets:
Cash and cash equivalents	$ 27,228,000	$ 22,726,000
Receivables	41,000	98,000
Prepaid expenses and other current assets	720,000	650,000
Total current assets	27,989,000	23,474,000
Property and equipment, net	60,000	50,000
Other non-current assets	150,000	150,000
Total assets	28,199,000	23,674,000
Current liabilities:
Accounts payable	5,148,000	4,271,000
Accrued expenses and other current liabilities	3,377,000	3,795,000
Deferred revenue	226,000	226,000
Total current liabilities	8,751,000	8,292,000
Warrant liability	232,000	113,000
Deferred revenue, non-current	3,583,000	3,695,000
Total liabilities	12,566,000	12,100,000
Commitments and contingencies
Stockholders' equity:
Preferred stock, $0.01 par value, 5,000,000 authorized at June 30, 2020 and December 31, 2019, none issued and outstanding at June 30, 2020 and December 31, 2019
Common stock, $0.01 par value, 250,000,000 authorized at June 30, 2020 and December 31, 2019, 174,177,448 and 111,167,352 shares issued and outstanding at June 30, 2020 and December 31, 2019	1,742,000	1,112,000
Additional paid in capital	429,794,000	413,879,000
Accumulated other comprehensive loss	(17,000)	(18,000)
Accumulated deficit	(415,886,000)	(403,399,000)
Total stockholders' equity	15,633,000	11,574,000
Total liabilities and stockholders' equity	$ 28,199,000	$ 23,674,000

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2020	Dec. 31, 2019
Condensed Consolidated Balance Sheets
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	250,000,000	250,000,000
Common stock, shares issued	174,177,448	111,167,352
Common stock, shares outstanding	174,177,448	111,167,352

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Condensed Consolidated Statements of Operations
Revenue	$ 56,000	$ 2,022,000	$ 108,000	$ 2,090,000
Operating expenses:
General and administrative	2,594,000	1,760,000	4,401,000	4,994,000
Research and development	4,801,000	3,895,000	8,171,000	7,969,000
Total operating expenses	7,395,000	5,655,000	12,572,000	12,963,000
Loss from operations	(7,339,000)	(3,633,000)	(12,464,000)	(10,873,000)
Change in fair value of warrant liability	(56,000)	32,000	(119,000)	(395,000)
Other income, net		40,000	96,000	107,000
Net loss	$ (7,395,000)	$ (3,561,000)	$ (12,487,000)	$ (11,161,000)
Net loss per share, basic and diluted (in dollars per share)	$ (0.04)	$ (0.60)	$ (0.08)	$ (1.89)
Basic and diluted weighted average shares outstanding (in shares)	169,552,619	5,948,471	164,949,353	5,919,446

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Comprehensive Loss - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Condensed Consolidated Statements of Comprehensive Loss
Net loss	$ (7,395,000)	$ (3,561,000)	$ (12,487,000)	$ (11,161,000)
Other comprehensive loss, before tax:
Foreign currency translation adjustments, net	7,000	4,000	1,000	(2,000)
Other comprehensive income (loss), net of tax	7,000	4,000	1,000	(2,000)
Comprehensive loss	$ (7,388,000)	$ (3,557,000)	$ (12,486,000)	$ (11,163,000)

Consolidated Statement of Stock

Consolidated Statement of Stockholders' Equity (Deficit) - USD ($)	Common Stock	Additional Paid in Capital	Accumulated deficit	Accumulated other comprehensive loss	Total
Balance at Dec. 31, 2018	$ 57,000	$ 387,238,000	$ (381,896,000)	$ (12,000)	$ 5,387,000
Balance (in shares) at Dec. 31, 2018	5,674,220
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(11,161,000)		(11,161,000)
Other comprehensive income				(2,000)	(2,000)
Stock-based compensation		805,000			805,000
Issuance of common stock, net	$ 1,000	391,000			392,000
Issuance of common stock, net (in shares)	103,520
Issuance of common stock upon exercise of warrants	$ 2,000	31,000			33,000
Issuance of common stock upon exercise of warrants (in shares)	220,784
Balance at Jun. 30, 2019	$ 60,000	388,465,000	(393,057,000)	(14,000)	(4,546,000)
Balance (in shares) at Jun. 30, 2019	5,998,524
Balance at Mar. 31, 2019	$ 59,000	387,919,000	(389,496,000)	(18,000)	(1,536,000)
Balance (in shares) at Mar. 31, 2019	5,895,004
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(3,561,000)		(3,561,000)
Other comprehensive income				4,000	4,000
Stock-based compensation		155,000			155,000
Issuance of common stock, net	$ 1,000	391,000			392,000
Issuance of common stock, net (in shares)	103,520
Balance at Jun. 30, 2019	$ 60,000	388,465,000	(393,057,000)	(14,000)	(4,546,000)
Balance (in shares) at Jun. 30, 2019	5,998,524
Balance at Dec. 31, 2019	$ 1,112,000	413,879,000	(403,399,000)	(18,000)	$ 11,574,000
Balance (in shares) at Dec. 31, 2019	111,167,352				111,167,352
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(12,487,000)		$ (12,487,000)
Other comprehensive income				1,000	1,000
Stock-based compensation		185,000			185,000
Issuance of common stock, net	$ 276,000	8,786,000			9,062,000
Issuance of common stock, net (in shares)	27,662,518
Issuance of common stock upon exercise of warrants	$ 341,000	6,956,000			7,297,000
Issuance of common stock upon exercise of warrants (in shares)	34,097,578
Issuance of common stock upon exercise of pre-funded warrants	$ 13,000	(12,000)			1,000
Issuance of common stock upon exercise of pre-funded warrants (in shares)	1,250,000
Balance at Jun. 30, 2020	$ 1,742,000	429,794,000	(415,886,000)	(17,000)	$ 15,633,000
Balance (in shares) at Jun. 30, 2020	174,177,448				174,177,448
Balance at Mar. 31, 2020	$ 1,674,000	428,189,000	(408,491,000)	(24,000)	$ 21,348,000
Balance (in shares) at Mar. 31, 2020	167,416,070
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(7,395,000)		(7,395,000)
Other comprehensive income				7,000	7,000
Stock-based compensation		92,000			92,000
Issuance of common stock upon exercise of warrants	$ 55,000	1,525,000			1,580,000
Issuance of common stock upon exercise of warrants (in shares)	5,511,378
Issuance of common stock upon exercise of pre-funded warrants	$ 13,000	(12,000)			1,000
Issuance of common stock upon exercise of pre-funded warrants (in shares)	1,250,000
Balance at Jun. 30, 2020	$ 1,742,000	$ 429,794,000	$ (415,886,000)	$ (17,000)	$ 15,633,000
Balance (in shares) at Jun. 30, 2020	174,177,448				174,177,448

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Cash Flows - USD ($)	6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019
Operating activities:
Net loss	$ (12,487,000)	$ (11,161,000)
Adjustment to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	5,000	8,000
Change in fair value of warrant liabilities	119,000	395,000
Stock compensation expense	185,000	805,000
Changes in assets and liabilities:
Receivables	57,000	(1,679,000)
Prepaid expenses and other current assets	(70,000)	(73,000)
Accounts payable	877,000	711,000
Accrued expenses and other current liabilities	(418,000)	(403,000)
Deferred revenue	(112,000)	(113,000)
Net cash used in operating activities	(11,844,000)	(11,510,000)
Investing activities:
Payments for purchase of property and equipment	(15,000)
Net cash used in investing activities	(15,000)
Financing activities:
Proceeds from the sale of common stock and warrants, net of costs	9,062,000	391,000
Proceeds from the exercise of warrants	7,298,000	33,000
Net cash provided by financing activities	16,360,000	424,000
Effect of foreign currency translation on cash	1,000	(2,000)
Net increase (decrease) in cash and cash equivalents	4,502,000	(11,088,000)
Cash and cash equivalents at beginning of period	22,726,000	16,970,000
Cash and cash equivalents at end of period	$ 27,228,000	$ 5,882,000

Nature of Business

Nature of Business	6 Months Ended
	Jun. 30, 2020
Nature of Business
Nature of Business	1. Nature of Business The Company Onconova Therapeutics, Inc. (the "Company") was incorporated in the State of Delaware on December 22, 1998 and commenced operations on January 1, 1999. The Company's headquarters are located in Newtown, Pennsylvania. The Company is a clinical-stage biopharmaceutical company focused on discovering and developing novel small molecule product candidates primarily to treat cancer. The Company has proprietary targeted cancer agents designed to work against specific cellular pathways that are important to cancer cells. We believe that the product candidates in our pipeline have the potential to be efficacious in a variety of cancers. The Company has three clinical-stage product candidates and several preclinical programs. During 2012, Onconova Europe GmbH was established as a wholly owned subsidiary of the Company for the purpose of further developing business in Europe. The Company has entered into several license and collaboration agreements. In 2011, the Company entered into a license agreement, as subsequently amended, with SymBio Pharmaceuticals Limited ("SymBio"), which grants SymBio certain rights to commercialize rigosertib in Japan and Korea. In December 2017, the Company entered into a license and collaboration agreement with HanX for the further development, registration and commercialization of ON 123300 in greater China. ON 123300 is a preclinical compound which the Company believes has the potential to overcome the limitations of current generation CDK 4/6 inhibitors. Under the terms of the agreement, the Company received an upfront payment, and will receive regulatory and commercial milestone payments, as well as royalties on Chinese sales. The key feature of the collaboration is that HanX provides all funding required for Chinese IND enabling studies performed for Chinese Food and Drug Administration IND approval. The Company and HanX also intended for these studies to comply with the FDA standards. Accordingly, such studies may be used by the Company for an IND filing with the FDA. The Chinese IND was approved in January 2020. The Company anticipates filing a US IND related to ON 123300 in Q4 of 2020. The Company maintains global rights outside of China. On March 2, 2018, the Company entered into a License, Development and Commercialization Agreement (the “Pint License Agreement”) with Pint International SA (which, together with its affiliate Pint Pharma GmbH, are collectively referred to as "Pint"). Under the terms of the agreement, the Company granted Pint an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and commercialize any pharmaceutical product containing rigosertib in all uses of rigosertib in certain Latin American countries. In May 2019, the Company entered into a License and Collaboration Agreement (the "HanX License Agreement") with HanX Biopharmaceuticals, Inc. ("HanX"). Under the terms of the HanX License Agreement, the Company granted HanX an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and commercialize any pharmaceutical product (the "HanX Product") containing rigosertib in all uses of rigosertib or the HanX Product in human therapeutic uses in the People's Republic of China, Hong Kong, Macau and Taiwan (the "HanX Territory"). In connection with the HanX License Agreement, the Company also entered into a Securities Purchase Agreement with each of HanX and Abundant New Investments Ltd. ("Abundant"), an affiliate of HanX (each, a "Securities Purchase Agreement" and together, the "Securities Purchase Agreements"). HanX did not fulfill its obligations under the HanX License Agreement and in January 2020, in accordance with the terms of the HanX License Agreement, the HanX License Agreement was deemed to be void ab initio. Upon this termination, the rights to HanX Product in the HanX Territory reverted to the Company in accordance with the terms of the HanX License Agreement. In addition, the Securities Purchase Agreements terminated automatically effective upon the termination of the HanX License Agreement in accordance with the Securities Purchase Agreements. In November 2019, the Company entered into a Distribution, License and Supply Agreement (the "Knight License Agreement") with Knight Therapeutics Inc. ("Knight"). Under the terms of the Knight License Agreement, the Company granted Knight (i) a non-exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and manufacture any product (the "Knight Licensed Product") containing rigosertib for Canada (and Israel, should Knight exercise its option as set forth in the Knight License Agreement) (the "Knight Territory") and in human uses (the "Field"), and (ii) an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to commercialize the Knight Licensed Product in the Knight Territory and in the Field. Knight has also agreed to obtain from the Company all of its requirements of the Knight Licensed Products for the Knight Territory, and the Company has agreed to supply Knight with all of its requirements of the Knight Licensed Products. In December 2019, the Company entered into a Distribution, License and Supply Agreement (the "STA License Agreement") with Specialised Therapeutics Asia Pte. Ltd. ("STA"). Under the terms of the STA License Agreement, the Company granted STA (i) a non-exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and manufacture any product (the "STA Licensed Product") containing rigosertib for Australia and New Zealand (the "STA Territory") and in human uses (the "Field"), and (ii) an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to commercialize the STA Licensed Product in the STA Territory and in the Field. STA has also agreed to obtain from the Company all of its requirements of the STA Licensed Products for the STA Territory, and the Company has agreed to supply STA with all of its requirements of the STA Licensed Products. Liquidity The Company has incurred recurring operating losses since inception. For the six months ended June 30, 2020, the Company incurred a net loss of $12,487,000 and as of June 30, 2020 the Company had generated an accumulated deficit of $415,886,000. The Company anticipates operating losses to continue for the foreseeable future due to, among other things, costs related to research, development of its product candidates and its preclinical programs, strategic alliances and its administrative organization. At June 30, 2020, the Company had cash and cash equivalents of $27,228,000. The Company will require substantial additional financing to fund its ongoing clinical trials and operations, and to continue to execute its strategy. In February and March 2019 the Company implemented a workforce reduction. Six employees were terminated, which represented approximately 24% of the Company's workforce. A severance related charge of approximately $1,843,000, which included a non-cash charge of approximately $415,000 related to the accelerated vesting of outstanding stock options, was recorded in the three months ended March 31, 2019. Of the total severance related charge of $1,843,000, $1,562,000 was recorded in general and administrative operating expenses and $281,000 was recorded in research and development operating expenses. The severance expense was paid in periodic amounts through February 2020. On September 25, 2019 the Company closed on an offering of common stock to certain investors. The Company issued 2,198,938 shares of common stock and amended warrants for the purchase of 2,198,938 shares of common stock. The investors, who were also holders of the Company's preferred stock warrants issued in February 2018 and/or May 2018, received a warrant amendment under which a certain number of such investors' preferred stock warrants received a reduction in exercise price and an extension of term. Net proceeds from the sale of common stock and the amendment of preferred stock warrants were approximately $3.3 million. In November 2019, the Company closed on an offering of units of common stock and warrants. The Company issued 30,250,000 shares of common stock, pre-funded warrants to purchase 24,750,000 shares of common stock, and common stock warrants to purchase 55,000,000 shares of common stock. Net proceeds were approximately $9.7 million. On December 10, 2019, the Company closed on an offering of units of common stock and warrants. The Company issued 14,326,648 shares of common stock and common stock warrants to purchase 7,163,324 shares of common stock. Net proceeds were approximately $4.4 million. On December 19, 2019, the Company also closed on an offering of units of common stock and warrants. The Company issued 13,878,864 shares of common stock and common stock warrants to purchase 6,939,432 shares of common stock. Net proceeds were approximately $4.4 million. During 2019, pre-funded warrants were exercised for 23,720,784 shares of common stock and net proceeds were $35,000. Also during 2019, common warrants were exercised for 21,014,378 shares of common stock and net proceeds were approximately $4.9 million. On January 3, 2020, the Company closed on an offering of common stock. The Company issued 27,662,518 shares of common stock and net proceeds were approximately $9.0 million. In addition, during the six months ended June 30, 2020; 35,347,578 warrants from the November and December 2019 offerings described above have been exercised, resulting in proceeds of $7.3 million. From July 1, 2020 to August 12, 2020, 9,400,819 warrants have been exercised resulting in proceeds of $2.5 million. The Company has and may continue to delay, scale-back, or eliminate certain of its research and development activities and other aspects of its operations until such time as the Company is successful in securing additional funding. The Company is exploring various dilutive and non-dilutive sources of funding, including equity financings, strategic alliances, business development and other sources. The future success of the Company is dependent upon its ability to obtain additional funding. There can be no assurance, however, that the Company will be successful in obtaining such funding in sufficient amounts, on terms acceptable to the Company, or at all. The Company currently anticipates that current cash and cash equivalents will be sufficient to meet its anticipated cash requirements into the fourth quarter of 2021.

Summary of Significant Accounti

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2020
Summary of Significant Accounting Policies
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies Basis of Presentation The condensed consolidated financial statements are prepared in conformity with accounting principles generally accepted in the United States (“GAAP”) for interim financial information. Certain information and footnotes normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”). The financial statements include the consolidated accounts of the Company and its wholly-owned subsidiary, Onconova Europe GmbH. All significant intercompany transactions have been eliminated. Unaudited Interim Financial Information The accompanying condensed consolidated balance sheet as of June 30, 2020, the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2020 and 2019, the consolidated statements of stockholders’ equity (deficit) for the three and six months ended June 30, 2020 and 2019 and the condensed consolidated statements of cash flows for the six months ended June 30, 2020 and 2019 are unaudited. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of June 30, 2020, the results of its operations for the three and six months ended June 30, 2020 and 2019, and its cash flows for the six months ended June 30, 2020 and 2019. The financial data and other information disclosed in these notes related to the three and six months ended June 30, 2020 and 2019 are unaudited. The results for the three and six months ended June 30, 2020 are not necessarily indicative of results to be expected for the year ending December 31, 2020, any other interim periods, or any future year or period. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the notes thereto for the year ended December 31, 2019 included in the Company’s annual report on Form 10-K filed with the SEC on March 27, 2020. Segment Information Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one segment, which is the identification and development of oncology therapeutics. Significant Accounting Policies The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2019 included in the Company’s annual report on Form 10-K filed with the SEC on March 27, 2020. Since the date of such financial statements, there have been no changes to the Company’s significant accounting policies. Fair Value Measurements The carrying amounts reported in the accompanying consolidated financial statements for cash and cash equivalents, accounts payable, and accrued liabilities approximate their respective fair values because of the short-term nature of these accounts. The fair value of the warrant liability is discussed in Note 7, “Fair Value Measurements.” Recent Accounting Pronouncements In February 2016 and through subsequent amendments, the FASB issued guidance which supersedes much of the previous guidance for leases. The new guidance requires lessees to recognize a right-of-use asset and a lease liability on their balance sheets for all the leases with terms greater than twelve months. Based on certain criteria, leases are classified as either financing or operating, with classification affecting the pattern of expense recognition in the income statement. For leases with a term of twelve months or less, a lessee is permitted to make an accounting policy election by class of underlying asset not to recognize lease assets and lease liabilities. If a lessee makes this election, it should recognize lease expense for such leases generally on a straight-line basis over the lease term. The guidance was effective for fiscal years beginning after December 15, 2018, and interim periods within those years, with early adoption permitted. In transition, lessees and lessors were permitted to recognize and measure leases at the date of adoption using a modified retrospective approach. The modified retrospective approach includes a number of optional practical expedients primarily focused on leases that commenced before the effective date of the new guidance, including continuing to account for leases that commence before the effective date in accordance with previous guidance, unless the lease is modified. The Company adopted the guidance in ASC 842 effective January 1, 2019 using the modified retrospective method, which does not require the restatement of prior period amounts. There was no impact to the Company’s financial position and results of operations as a result of the adoption. In August 2018, the FASB issued guidance which changes the disclosure requirements for fair value measurement. The guidance amends the disclosure requirements in ASC Topic 820 by adding, changing, or removing certain disclosures. The guidance is effective for fiscal years beginning after December 15, 2019. The Company adopted this guidance effective January 1, 2020. There was no impact to the Company’s financial position, results of operations or financial statement disclosures as a result of the adoption. In November 2018, the FASB issued guidance, which clarifies the interaction between ASC Topic 808, Collaborative Arrangements , and ASC Topic 606, Revenue from Contracts with Customers . The guidance, among other items, clarifies that certain transactions between collaborative participants should be accounted for as revenue under Topic 606 when the collaborative arrangement participant is a customer in the context of a unit of account. The guidance is effective for fiscal years beginning after December 15, 2019. The Company adopted this guidance effective January 1, 2020. There was no impact to the Company’s financial position and results of operations as a result of the adoption. In June 2016, the FASB issued new guidance on the accounting for credit losses on financial instruments. The guidance was amended in November 2019. The new guidance introduces an expected loss model for estimating credit losses, replacing the incurred loss model. The new guidance also changes the impairment model for available-for-sale debt securities, requiring the use of an allowance to record estimated credit losses (and subsequent recoveries). The guidance is effective for fiscal years beginning after December 15, 2022, and interim periods within those years, with early adoption permitted. The Company is evaluating the impact of the adoption of the standard on its consolidated financial statements.

Revenue

Revenue	6 Months Ended
	Jun. 30, 2020
Revenue.
Revenue	3. Revenue The Company’s revenue during the three and six months ended June 30, 2020 and 2019 was from its license and collaboration agreements with SymBio and HanX. Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Symbio Upfront license fee recognition over time $ 56,000 $ 56,000 $ 112,000 $ 113,000 Supplies and other — 1,000 (4,000) 12,000 HanX - rigosertib Upfront license payment — 1,965,000 — 1,965,000 $ 56,000 $ 2,022,000 $ 108,000 $ 2,090,000 Deferred revenue is as follows: Symbio Upfront Payment Deferred balance at December 31, 2019 $ 3,921,000 Recognition to revenue 112,000 Deferred balance at June 30, 2020 $ 3,809,000

Net Loss Per Share of Common St

Net Loss Per Share of Common Stock	6 Months Ended
	Jun. 30, 2020
Net Loss Per Share of Common Stock
Net Loss Per Share of Common Stock	4. Net Loss Per Share of Common Stock The following potentially dilutive securities outstanding at June 30, 2020 and 2019 have been excluded from the computation of diluted weighted average shares outstanding, as they would be antidilutive (reflects the number of common shares as if the dilutive securities had been converted to common stock): June 30, 2020 2019 Warrants 21,862,189 5,504,722 Stock options 1,044,591 355,794 22,906,780 5,860,516

Warrants

Warrants	6 Months Ended
	Jun. 30, 2020
Warrants
Warrants	5. Warrants Common Stock warrants are accounted for in accordance with applicable accounting guidance provided in ASC Topic 815, Derivatives and Hedging - Contracts in Entity’s Own Equity (ASC Topic 815), as either derivative liabilities or as equity instruments depending on the specific terms of the warrant agreement. Some of the Company’s warrants are classified as liabilities because in certain circumstances they could require cash settlement. Warrants outstanding and warrant activity (reflects the number of common shares as if the warrants were converted to common stock) for the six months ended June 30, 2020 is as follows: Balance Balance Exercise Expiration December 31, Warrants Warrants June 30, Description Classification Price Date 2019 Issued Exercised 2020 Non-tradable warrants Liability $ 172.50 July 2021 6,456 — — 6,456 Tradable warrants Liability $ 73.80 July 2021 212,801 — — 212,801 Non-tradable pre-funded warrants Equity $ 0.15 July 2023 394 — — 394 Non-tradable warrants Equity $ 1.60 December 2022 392,834 — — 392,834 Non-tradable warrants Equity $ 14.10 March 2021 5,000 — — 5,000 Non-tradable warrants Equity $ 21.15 March 2021 8,333 — — 8,333 Non-tradable warrants Equity $ 7.7895 June 2021 15,000 — — 15,000 Non-tradable pre-funded warrants Equity $ 0.15 none 52,834 — — 52,834 Non-tradable warrants Equity $ 1.600 December 2022 1,806,104 — — 1,806,104 Non-tradable pre-funded warrants Equity $ 0.15 none 74,617 — — 74,617 Non-tradable warrants Equity $ 2.00 September 2023 109,585 — — 109,585 Non-tradable pre-funded warrants Equity $ 0.0001 none 1,250,000 — (1,250,000) — Non-tradable warrants Equity $ 0.20 November 2024 41,037,000 — (29,046,200) 11,990,800 Non-tradable warrants Equity $ 0.250 November 2024 2,521,875 — — 2,521,875 Non-tradable warrants Equity $ 0.287 December 2024 3,581,662 — (1,581,662) 2,000,000 Non-tradable warrants Equity $ 0.43625 December 2024 716,332 — — 716,332 Non-tradable warrants Equity $ 0.298 December 2024 3,469,716 — (3,469,716) — Non-tradable warrants Equity $ 0.45030 December 2024 693,943 — 693,943 Non-tradable warrants Equity $ 0.45190 December 2023 — 1,383,126 1,383,126 55,954,486 1,383,126 (35,347,578) 21,990,034

Balance Sheet Detail

Balance Sheet Detail	6 Months Ended
	Jun. 30, 2020
Balance Sheet Detail
Balance Sheet Detail	6. Balance Sheet Detail Prepaid expenses and other current assets: June 30, December 31, 2020 2019 Research and development $ 281,000 $ 321,000 Manufacturing 70,000 25,000 Insurance 57,000 164,000 Other 312,000 140,000 $ 720,000 $ 650,000 Property and equipment: June 30, December 31, 2020 2019 Property and equipment $ 2,298,000 $ 2,283,000 Accumulated depreciation (2,238,000) (2,233,000) $ 60,000 $ 50,000 Accrued expenses and other current liabilities: June 30, December 31, 2020 2019 Research and development $ 2,165,000 $ 2,016,000 Employee compensation 977,000 1,537,000 Professional fees 235,000 242,000 $ 3,377,000 $ 3,795,000

Fair Value Measurements

Fair Value Measurements	6 Months Ended
	Jun. 30, 2020
Fair Value Measurements
Fair Value Measurements	7. Fair Value Measurements Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The Company utilizes a valuation hierarchy for disclosure of the inputs to the valuations used to measure fair value. This hierarchy prioritizes the inputs into three broad levels as follows. Level 1 inputs are quoted prices (unadjusted) in active markets for identical assets or liabilities. Level 2 inputs are quoted prices for similar assets and liabilities in active markets or inputs that are observable for the asset or liability, either directly or indirectly through market corroboration, for substantially the full term of the financial instrument. Level 3 inputs are unobservable inputs based on the Company’s own assumptions used to measure assets and liabilities at fair value. A financial asset or liability’s classification within the hierarchy is determined based on the lowest level input that is significant to the fair value measurement. On January 5, 2016, the Company entered into a securities purchase agreement (the “Securities Purchase Agreement”) with an institutional investor providing for the issuance and sale by the Company of 12,912 shares of Common Stock, at a purchase price of $142.50 per share and warrants to purchase up to 6,456 shares of Common Stock (the “Warrants”) for aggregate gross proceeds of $1,840,000. The Company has classified the warrants as a liability (see Note 5). The estimated fair value using the Black-Scholes pricing model was approximately $0 at June 30, 2020 and December 31, 2019. On July 29, 2016 the Company closed on a Rights Offering, issuing 239,986 shares of Common Stock, 212,801 Tradable Warrants and 43,760 Pre-Funded Warrants. The Tradable Warrants are exercisable for a period of five years for one share of Common Stock at an exercise price of $73.80 per share. After the one-year anniversary of issuance, the Company may redeem the Tradable Warrants for $0.001 per Tradable Warrant if the volume weighted average price of its Common Stock is above $184.50 for each of 10 consecutive trading days. The Company has classified the Tradable Warrants as a liability (see Note 5). The Tradable Warrants have been listed on the Nasdaq Capital Market since issuance and the Company regularly monitors the trading activity. The Company has determined that an active and orderly market for the Tradable Warrants has developed and that the Nasdaq Capital Market price is the best indicator of fair value of the warrant liability. The quoted market price was used to determine the fair value at December 31, 2019 and June 30, 2020. The Company estimated the fair value of the non-tradable warrant liability at June 30, 2020, using the Black-Scholes option pricing model with the following weighted-average assumptions: Risk-free interest rate 0.16 % Expected volatility 105.44 % Expected term 1.08 years Expected dividend yield 0 % Expected volatility is based on the historical volatility of the Company’s Common Stock since its IPO in July 2013. The following fair value hierarchy table presents information about the Company’s financial assets and liabilities measured at fair value on a recurring basis as of June 30, 2020 and December 31, 2019: Fair Value Measurement as of: June 30, 2020 December 31, 2019 Level 1 Level 2 Level 3 Balance Level 1 Level 2 Level 3 Balance Tradable warrants liability $ 232,000 $ — $ — $ 232,000 $ 113,000 $ — $ — $ 113,000 Non-tradable warrants liability — — — — — — — — Total $ 232,000 $ — $ — $ 232,000 $ 113,000 $ — $ — $ 113,000 There were no transfers between Level 1 and Level 2 in any of the periods reported.

Stock-Based Compensation

Stock-Based Compensation	6 Months Ended
	Jun. 30, 2020
Stock-Based Compensation
Stock-Based Compensation	8. Stock-Based Compensation The 2007 Equity Compensation Plan as amended (the “2007 Plan”), amended, restated and renamed the Company’s 1999 Stock Based Compensation Plan (the “1999 Plan”), which provided for the granting of incentive and nonqualified stock options and restricted stock to its employees, directors and consultants at the discretion of the board of directors. The 2013 Equity Compensation Plan (the “2013 Plan”), amended, restated and renamed the 2007 Plan. Under the 2013 Plan, the Company may grant incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock, restricted stock units, deferred share awards, performance awards and other equity-based awards to employees, directors and consultants. The Company initially reserved 40,718 shares of Common Stock for issuance, subject to adjustment as set forth in the 2013 Plan. The 2013 Plan included an evergreen provision, pursuant to which the maximum aggregate number of shares that may be issued under the 2013 Plan is increased on the first day of each fiscal year by the lesser of (a) a number of shares equal to four percent (4%) of the issued and outstanding Common Stock of the Company, without duplication, (b) 13,333 shares and (c) such lesser number as determined by the Company’s board of directors, subject to specified limitations. The 2018 Omnibus Incentive Compensation Plan (the “2018 Plan”) was unanimously approved by the Company’s Board of Directors on May 24, 2018 and was approved by the Company’s stockholders on June 27, 2018. The 2018 Plan replaces the 2013 Plan. Upon stockholders’ approval of the 2018 Plan, no further awards will be made under the 2013 Plan. Awards granted under the 2013 Plan will continue in effect in accordance with the terms of the applicable award agreement and the terms of the 2013 Plan in effect when the awards were granted. Under the 2018 Plan, the Company may grant incentive stock options, non-qualified stock options, stock awards, stock units, stock appreciation rights and other stock-based awards to employees, non-employee directors and consultants, and advisors. The maximum aggregate number of shares of the Company’s common stock that may be issued under the 2018 Plan is 402,354, which is equal to the sum of (i) 400,000 shares of the Company’s common stock, plus (ii) 2,354 shares, which is the number of shares of the Company common stock reserved for issuance under the 2013 Plan that remained available as of the effective date of the 2018 Plan. In addition, the number of shares of common stock subject to outstanding awards under the 2013 Plan that terminate, expire, or are cancelled, forfeited, exchanged, or surrendered without having been exercised, vested, or paid in shares under the 2013 Plan after the effective date of the 2018 Plan will be available for issuance under the 2018 Plan. The 2018 Plan was amended following unanimous approval of the Company’s Board of Directors on April 24, 2019 and was approved by the Company’s shareholders on June 17, 2019. The amended 2018 Plan (the “Amended Plan”) allowed for an additional 589,500 shares of the Company’s common stock that may be issued under the Amended Plan with respect to awards made on and after June 17, 2019. At June 30, 2020, there were 9,593 shares available for future issuance. Stock-based compensation expense includes stock options granted to employees and non-employees and has been reported in the Company’s statements of operations and comprehensive loss in either research and development expenses or general and administrative expenses depending on the function performed by the optionee. No net tax benefits related to the stock-based compensation costs have been recognized since the Company’s inception. The Company recognized stock-based compensation expense as follows for the three and six months ended June 30, 2020 and 2019: Three Months ended June 30, Six Months ended June 30, 2020 2019 2020 2019 General and administrative $ 46,000 $ 67,000 $ 91,000 $ 606,000 Research and development 46,000 88,000 94,000 199,000 $ 92,000 $ 155,000 $ 185,000 $ 805,000 A summary of stock option activity for the six months ended June 30, 2020 is as follows: Options Outstanding Weighted Weighted- Average Shares Average Remaining Aggregate Available Number of Exercise Contractual Intrinsic for Grant Shares Price Term (in years) Value Balance, December 31, 2019 59,731 994,453 $ 27.37 9.32 $ — Authorized — — Granted (63,250) 63,250 $ 0.307 9.77 Exercised — — $ — Forfeitures 13,112 (13,112) $ 168.21 7.92 Balance, June 30, 2020 9,593 1,044,591 $ 24.08 8.89 $ — Vested or expected to vest, June 30, 2020 1,012,646 $ 89.06 7.60 $ — Exercisable at June 30, 2020 272,982 $ 89.06 7.60 $ — Information with respect to stock options outstanding and exercisable at June 30, 2020 is as follows: Exercise Price Shares Exercisable $0.29 - $0.36 658,250 — $3.39 – $3.72 51,998 9,916 $4.34 – $7.05 269,222 199,860 $16.35 – $97.50 47,897 45,996 $222.00 - $225.00 1,871 1,871 $348.00 – $597.00 4,801 4,800 $651.00 – $1,129.50 3,481 3,468 $1,992.00 - $2,268.00 6,736 6,736 $4,156.50 - $4,371.00 335 335 1,044,591 272,982 The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes model requires the Company to make certain estimates and assumptions, including estimating the fair value of the Company’s Common Stock, assumptions related to the expected price volatility of the Common Stock, the period during which the options will be outstanding, the rate of return on risk-free investments and the expected dividend yield for the Company’s stock. As of June 30, 2020, there was $525,000 of unrecognized compensation expense related to the unvested stock options issued from April 24, 2013 through June 30, 2020, which is expected to be recognized over a weighted-average period of approximately 2.12 years. The weighted-average assumptions underlying the Black-Scholes calculation of grant date fair value include the following: Six Months ended June 30, 2020 2019 Risk-free interest rate 0.45 % 2.27 % Expected volatility 105.14 % 83.68 % Expected term 6.00 years 6.25 years Expected dividend yield 0 % 0 % Weighted average grant date fair value $ 0.25 $ 12.60 The weighted-average valuation assumptions were determined as follows: · Risk-free interest rate: The Company based the risk-free interest rate on the interest rate payable on U.S. Treasury securities in effect at the time of grant for a period that is commensurate with the assumed expected option term. · Expected term of options: Due to its lack of sufficient historical data, the Company estimates the expected life of its employee stock options using the “simplified” method, as prescribed in Staff Accounting Bulletin (SAB) No. 107, whereby the expected life equals the arithmetic average of the vesting term and the original contractual term of the option. · Expected stock price volatility: Expected volatility is based on the historical volatility of the Company’s Common Stock since its IPO in July 2013. · Expected annual dividend yield: The Company has never paid, and does not expect to pay, dividends in the foreseeable future. Accordingly, the Company assumed an expected dividend yield of 0.0%. · Estimated forfeiture rate: The Company’s estimated annual forfeiture rate on stock option grants was 4.14% in 2020 and 2019, based on the historical forfeiture experience.

Research Agreements

Research Agreements	6 Months Ended
	Jun. 30, 2020
Research Agreements
Research Agreements	9. Research Agreements The Company has entered into various licensing and right-to-sublicense agreements with educational institutions for the exclusive use of patents and patent applications, as well as any patents that may develop from research being conducted by such educational institutions in the field of anticancer therapy, genes and proteins. Results from this research have been licensed to the Company pursuant to these agreements. Under one of these agreements with Temple University (“Temple”), the Company is required to make annual maintenance payments to Temple and royalty payments based upon a percentage of sales generated from any products covered by the licensed patents, with minimum specified royalty payments. As no sales had been generated through June 30, 2020 under the licensed patents, the Company has not incurred any royalty expenses related to this agreement. In addition, the Company is required to pay Temple a percentage of any sublicensing fees received by the Company.

License and Collaboration Agree

License and Collaboration Agreement	6 Months Ended
	Jun. 30, 2020
License and Collaboration Agreement
License and Collaboration Agreements	10. License and Collaboration Agreement HanX Rigosertib Agreement (terminated) On May 10, 2019, the Company entered into a License and Collaboration Agreement (the “HanX License Agreement”) with HanX and two Securities Purchase Agreements (the “HanX Securities Purchase Agreements”), one with HanX and the other with an affiliate of HanX. Under the terms of the HanX License Agreement, the Company granted HanX an exclusive, royalty-bearing license, with the right to sublicense, to study and commercialize rigosertib in greater China (the “HanX Territory,” including the People’s Republic of China, Hong Kong, Macau and Taiwan). In exchange for these rights, the agreement required HanX to make upfront payments to the Company totaling $4 million, including a $2.0 million upfront fee and an investment totaling $2.0 million to purchase shares of the Company at a premium to market. HanX was also required to dedicate $2.0 million in local currency, to be placed in escrow, for clinical development expenses in the HanX Territory. In addition, the agreement provided for potential payments to the Company for regulatory, development and sales-based milestone payments up to $45.5 million and tiered royalties up to double digits on net sales in in the HanX Territory. The Company would supply rigosertib for sale in the HanX Territory. The HanX License Agreement also contained certain provisions for termination by either party in the event of breach of the HanX License Agreement by the other party, subject to a cure period, or bankruptcy of the other party. Under the terms of the HanX Securities Purchase Agreement, HanX and its affiliate agreed to make upfront equity investments in the Company at a specified premium to the Company’s share price. The common stock purchased by HanX and its affiliates is subject to certain lock-up restrictions and HanX and its affiliates are entitled to certain registration and participation rights. The Company assessed the HanX License Agreement for revenue recognition in accordance with ASC 606 and determined that there are two distinct performance obligations: the license and the supply of rigosertib for sale in the HanX Territory. The Company concluded that control of the license had been transferred to HanX during the three months ended June 30, 2019 and recognized license revenue of $1.7 million, which is net of applicable taxes withheld by the Chinese government, related to the $2.0 million upfront fee. The Company believes a portion of the tax being withheld by the Chinese government may be recoverable at a later date and could be recognized as license revenue if and when recovered by the Company. The $1.7 million was recorded as a receivable at June 30, 2019 and the payment was received in August 2019. Pursuant to the HanX Securities Purchase Agreements, closing of one of the upfront equity investments occurred on May 15, 2019 when an affiliate of HanX purchased 103,520 shares of common stock for $0.5 million. The total amount of the premium was $0.1 million and this amount was recognized as license revenue during the three months ended June 30, 2019. On July 9, 2019, the Company extended the deadline for payments under the HanX License Agreement and the HanX Securities Purchase Agreements. On August 8, 2019 the Company received the non-refundable license fee from HanX. On August 14, 2019, the Company further extended the deadline of HanX's remaining upfront payments relating to its equity investment in the Company while HanX continued to seek Chinese regulatory approval for such equity investment. In December 2019, the Company reassessed the likelihood of receiving the $0.2 million premium on the equity investment previously recorded as revenue. The Company reversed the $0.2 million revenue in December 2019. On January 16, 2020, the Company determined HanX did not fulfill its obligations under the License Agreement and, in accordance with the terms of the License Agreement, the License Agreement was deemed to be void ab initio. Upon this termination, the rights to Product in the Territory reverted to the Company in accordance with the terms of the License Agreement. In addition, the Securities Purchase Agreements terminated automatically effective upon the termination of the License Agreement in accordance with the Securities Purchase Agreements.

Related-Party Transactions

Related-Party Transactions	6 Months Ended
	Jun. 30, 2020
Related-Party Transactions
Related-Party Transactions	11. Related-Party Transactions The Company has entered into a research agreement, as subsequently amended, with the Mount Sinai School of Medicine (“Mount Sinai”), with which a member of its board of directors and a stockholder is affiliated. Mount Sinai is undertaking research on behalf of the Company on the terms set forth in the agreements. Mount Sinai, in collaboration with the Company, will prepare applications for patents generated from the research. Results from all projects will belong exclusively to Mount Sinai, but the Company will have an exclusive option to license any inventions, resulting therefrom. Payments to Mount Sinai under this research agreement for the three months ended June 30, 2020 and 2019 were $77,000 and $88,000, respectively, and for the six months ended June 30, 2020 and 2019 were $201,000 and $175,000, respectively. At June 30, 2020 and December 31, 2019, the Company had $77,000 and $150,000, respectively, payable to Mount Sinai under this agreement. The Company has entered into a consulting agreement with a member of its board of directors. The board member provides consulting services to the Company on the terms set forth in the agreement. Payments to this board member for both the three months ended June 30, 2020 and 2019 were $33,000 and for both the six months ended June 30, 2020 and 2019 were $66,000. At both June 30, 2020 and December 31, 2019, the Company had $33,000 payable under this agreement.

Securities Registrations and Sa

Securities Registrations and Sales Agreements	6 Months Ended
	Jun. 30, 2020
Securities Registrations and Sales Agreements
Securities Registrations and Sales Agreements	12. Securities Registrations and Sales Agreements January 2020 Offering On December 31, 2019, the Company entered into definitive securities purchase agreements with institutional investors for the issuance and sale in a registered direct offering of 27,662,518 shares of the Company's common stock at an offering price of $0.3615 per share. Pursuant to a December 2019 engagement letter with H. C. Wainwright & Co., HCW agreed to serve as exclusive placement agent for the offering. In connection with the offering, the Company paid HCW an aggregate cash fee equal to 7.0% of the gross proceeds in the offering, management fee equal to 1.0% of the gross proceeds raised in the offering, $85,000 for non-accountable expenses; and $10,000 for clearing fees. The Company also issued to HCW or its designees placement agent warrants to purchase up to 1,383,126 shares of common stock at an exercise price of $0.4519 per share. The placement agent warrants are immediately exercisable and will expire on December 31, 2023. The net proceeds to the Company from the offering, after deducting HCW's placement agent fees and expenses and other estimated offering expenses payable by the Company were approximately $9.0 million and were received in January 2020. The offering was pursuant to a prospectus dated December 28, 2017, and a prospectus supplement dated as of December 31, 2019 to be filed in connection with a takedown from the Company's shelf registration statement on Form S-3 (File No. 333-221684). The offering closed on January 3, 2020.

Subsequent Event

Subsequent Event	6 Months Ended
	Jun. 30, 2020
Subsequent Event
Subsequent Event	13. Subsequent Events Grants of PSUs and SARs On July 9, 2020, the compensation committee of the board of directors and the board approved a cash bonus program of cash-settled stock appreciation right (“SAR”) awards and cash-settled performance stock unit (“PSU”) awards to the Company’s employees. An aggregate of SAR awards with respect to 3,850,700 shares of common stock and PSU awards with respect to 1,863,300 shares of common stock were granted to the Company’s employees. The SAR awards will be settled in cash, vest 33% on the first anniversary of the date of grant, and the remaining 67% monthly over the next 24 months, have a per-share base amount of $0.56, which was the closing sales price of a share of the Company’s common stock on the grant date, and are in all cases subject to the terms and conditions of the Company’s form of SAR award agreement. The PSU awards vest 50% upon the submission of a new drug application (“NDA”) to the U.S. FDA for rigosertib in higher-risk myelodysplastic syndromes (“HR-MDS”) and 50% upon U.S. FDA approval of rigosertib for HR-MDS. The PSU awards have a maximum value of $1.44 per share. The maximum price per share is the per-share value based on the Company’s market capitalization at $250 million and the Company’s outstanding shares of common stock, which was 174,177,448 shares on July 9, 2020. In all cases, the PSU awards are subject to the terms and conditions of the Company’s form of PSU award agreement. In addition, on July 9, 2020, based on the recommendation of the compensation committee, the board approved a change in the non-employee director compensation policy that would provide for an annual SAR award with respect to 125,000 shares of common stock for each of the Company’s non-employee directors. No other changes to the non-employee director compensation policy were approved and, on July 9, 2020, the Board approved the initial 125,000 SAR award to each of the non-employee directors. The SAR awards vest on the first anniversary of grant subject to the director’s continued service and will be settled in cash, have a per-share base amount of $0.56, and are in all cases subject to the terms and conditions of the Company’s form of SAR award agreement. Each SAR subject to an SAR award represents the right to a cash payment equal to the excess, if any, of (i) the fair market value of each underlying share of the Company’s common stock, determined on the date of exercise of the SAR minus (ii) the base amount. Pursuant to the terms of the SAR awards, in no event may the cash payment for each SAR exceed $0.88, which is the maximum price per share of $1.44, minus the base amount of $0.56, subject to adjustment in accordance with the terms of the Stock Appreciation Right Award Agreement. The maximum price per share is the per-share value based on the Company’s market capitalization at $250 million and the Company’s outstanding shares of common stock, which was 174,177,448 shares on July 9, 2020. As of August 12, 2020, none of these SAR or PSU awards have vested. As such, no estimate of a liability for these cash-settled awards is possible. The Company will evaluate these awards at each quarterly reporting period to determine what disclosure or accrual is required. Exercise of Common Stock Warrants From July 1, 2020 to August 12, 2020, 9,400,819 warrants have been exercised resulting in proceeds of $2.5 million.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2020
Summary of Significant Accounting Policies
Basis of Presentation	Basis of Presentation The condensed consolidated financial statements are prepared in conformity with accounting principles generally accepted in the United States (“GAAP”) for interim financial information. Certain information and footnotes normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”). The financial statements include the consolidated accounts of the Company and its wholly-owned subsidiary, Onconova Europe GmbH. All significant intercompany transactions have been eliminated.
Unaudited Interim Financial Information	Unaudited Interim Financial Information The accompanying condensed consolidated balance sheet as of June 30, 2020, the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2020 and 2019, the consolidated statements of stockholders’ equity (deficit) for the three and six months ended June 30, 2020 and 2019 and the condensed consolidated statements of cash flows for the six months ended June 30, 2020 and 2019 are unaudited. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of June 30, 2020, the results of its operations for the three and six months ended June 30, 2020 and 2019, and its cash flows for the six months ended June 30, 2020 and 2019. The financial data and other information disclosed in these notes related to the three and six months ended June 30, 2020 and 2019 are unaudited. The results for the three and six months ended June 30, 2020 are not necessarily indicative of results to be expected for the year ending December 31, 2020, any other interim periods, or any future year or period. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the notes thereto for the year ended December 31, 2019 included in the Company’s annual report on Form 10-K filed with the SEC on March 27, 2020.
Segment Information	Segment Information Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one segment, which is the identification and development of oncology therapeutics.
Significant Accounting Policies	Significant Accounting Policies The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2019 included in the Company’s annual report on Form 10-K filed with the SEC on March 27, 2020. Since the date of such financial statements, there have been no changes to the Company’s significant accounting policies.
Fair Value Measurements	Fair Value Measurements The carrying amounts reported in the accompanying consolidated financial statements for cash and cash equivalents, accounts payable, and accrued liabilities approximate their respective fair values because of the short-term nature of these accounts. The fair value of the warrant liability is discussed in Note 7, “Fair Value Measurements.”
Recent Accounting Pronouncements	Recent Accounting Pronouncements In February 2016 and through subsequent amendments, the FASB issued guidance which supersedes much of the previous guidance for leases. The new guidance requires lessees to recognize a right-of-use asset and a lease liability on their balance sheets for all the leases with terms greater than twelve months. Based on certain criteria, leases are classified as either financing or operating, with classification affecting the pattern of expense recognition in the income statement. For leases with a term of twelve months or less, a lessee is permitted to make an accounting policy election by class of underlying asset not to recognize lease assets and lease liabilities. If a lessee makes this election, it should recognize lease expense for such leases generally on a straight-line basis over the lease term. The guidance was effective for fiscal years beginning after December 15, 2018, and interim periods within those years, with early adoption permitted. In transition, lessees and lessors were permitted to recognize and measure leases at the date of adoption using a modified retrospective approach. The modified retrospective approach includes a number of optional practical expedients primarily focused on leases that commenced before the effective date of the new guidance, including continuing to account for leases that commence before the effective date in accordance with previous guidance, unless the lease is modified. The Company adopted the guidance in ASC 842 effective January 1, 2019 using the modified retrospective method, which does not require the restatement of prior period amounts. There was no impact to the Company’s financial position and results of operations as a result of the adoption. In August 2018, the FASB issued guidance which changes the disclosure requirements for fair value measurement. The guidance amends the disclosure requirements in ASC Topic 820 by adding, changing, or removing certain disclosures. The guidance is effective for fiscal years beginning after December 15, 2019. The Company adopted this guidance effective January 1, 2020. There was no impact to the Company’s financial position, results of operations or financial statement disclosures as a result of the adoption. In November 2018, the FASB issued guidance, which clarifies the interaction between ASC Topic 808, Collaborative Arrangements , and ASC Topic 606, Revenue from Contracts with Customers . The guidance, among other items, clarifies that certain transactions between collaborative participants should be accounted for as revenue under Topic 606 when the collaborative arrangement participant is a customer in the context of a unit of account. The guidance is effective for fiscal years beginning after December 15, 2019. The Company adopted this guidance effective January 1, 2020. There was no impact to the Company’s financial position and results of operations as a result of the adoption. In June 2016, the FASB issued new guidance on the accounting for credit losses on financial instruments. The guidance was amended in November 2019. The new guidance introduces an expected loss model for estimating credit losses, replacing the incurred loss model. The new guidance also changes the impairment model for available-for-sale debt securities, requiring the use of an allowance to record estimated credit losses (and subsequent recoveries). The guidance is effective for fiscal years beginning after December 15, 2022, and interim periods within those years, with early adoption permitted. The Company is evaluating the impact of the adoption of the standard on its consolidated financial statements.

Revenue (Tables)

Revenue (Tables)	6 Months Ended
	Jun. 30, 2020
Revenue.
Schedule of recognized revenue under funding, license and collaboration agreements	Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Symbio Upfront license fee recognition over time $ 56,000 $ 56,000 $ 112,000 $ 113,000 Supplies and other — 1,000 (4,000) 12,000 HanX - rigosertib Upfront license payment — 1,965,000 — 1,965,000 $ 56,000 $ 2,022,000 $ 108,000 $ 2,090,000
Schedule of deferred revenue	Symbio Upfront Payment Deferred balance at December 31, 2019 $ 3,921,000 Recognition to revenue 112,000 Deferred balance at June 30, 2020 $ 3,809,000

Net Loss Per Share of Common _2

Net Loss Per Share of Common Stock (Tables)	6 Months Ended
	Jun. 30, 2020
Net Loss Per Share of Common Stock
Schedule of antidilutive securities which have been excluded from the computation of diluted weighted average shares outstanding	June 30, 2020 2019 Warrants 21,862,189 5,504,722 Stock options 1,044,591 355,794 22,906,780 5,860,516

Warrants (Tables)

Warrants (Tables)	6 Months Ended
	Jun. 30, 2020
Warrants
Schedule of warrants outstanding and warrant activity	Balance Balance Exercise Expiration December 31, Warrants Warrants June 30, Description Classification Price Date 2019 Issued Exercised 2020 Non-tradable warrants Liability $ 172.50 July 2021 6,456 — — 6,456 Tradable warrants Liability $ 73.80 July 2021 212,801 — — 212,801 Non-tradable pre-funded warrants Equity $ 0.15 July 2023 394 — — 394 Non-tradable warrants Equity $ 1.60 December 2022 392,834 — — 392,834 Non-tradable warrants Equity $ 14.10 March 2021 5,000 — — 5,000 Non-tradable warrants Equity $ 21.15 March 2021 8,333 — — 8,333 Non-tradable warrants Equity $ 7.7895 June 2021 15,000 — — 15,000 Non-tradable pre-funded warrants Equity $ 0.15 none 52,834 — — 52,834 Non-tradable warrants Equity $ 1.600 December 2022 1,806,104 — — 1,806,104 Non-tradable pre-funded warrants Equity $ 0.15 none 74,617 — — 74,617 Non-tradable warrants Equity $ 2.00 September 2023 109,585 — — 109,585 Non-tradable pre-funded warrants Equity $ 0.0001 none 1,250,000 — (1,250,000) — Non-tradable warrants Equity $ 0.20 November 2024 41,037,000 — (29,046,200) 11,990,800 Non-tradable warrants Equity $ 0.250 November 2024 2,521,875 — — 2,521,875 Non-tradable warrants Equity $ 0.287 December 2024 3,581,662 — (1,581,662) 2,000,000 Non-tradable warrants Equity $ 0.43625 December 2024 716,332 — — 716,332 Non-tradable warrants Equity $ 0.298 December 2024 3,469,716 — (3,469,716) — Non-tradable warrants Equity $ 0.45030 December 2024 693,943 — 693,943 Non-tradable warrants Equity $ 0.45190 December 2023 — 1,383,126 1,383,126 55,954,486 1,383,126 (35,347,578) 21,990,034

Balance Sheet Detail (Tables)

Balance Sheet Detail (Tables)	6 Months Ended
	Jun. 30, 2020
Balance Sheet Detail
Schedule of prepaid expenses and other current assets	June 30, December 31, 2020 2019 Research and development $ 281,000 $ 321,000 Manufacturing 70,000 25,000 Insurance 57,000 164,000 Other 312,000 140,000 $ 720,000 $ 650,000
Schedule of property and equipment	June 30, December 31, 2020 2019 Property and equipment $ 2,298,000 $ 2,283,000 Accumulated depreciation (2,238,000) (2,233,000) $ 60,000 $ 50,000
Schedule of accrued expenses and other current liabilities	June 30, December 31, 2020 2019 Research and development $ 2,165,000 $ 2,016,000 Employee compensation 977,000 1,537,000 Professional fees 235,000 242,000 $ 3,377,000 $ 3,795,000

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	6 Months Ended
	Jun. 30, 2020
Fair Value Measurements
Schedule of Black-Scholes option pricing model assumptions	Risk-free interest rate 0.16 % Expected volatility 105.44 % Expected term 1.08 years Expected dividend yield 0 %
Schedule of financial assets and liabilities measured at fair value on a recurring basis	Fair Value Measurement as of: June 30, 2020 December 31, 2019 Level 1 Level 2 Level 3 Balance Level 1 Level 2 Level 3 Balance Tradable warrants liability $ 232,000 $ — $ — $ 232,000 $ 113,000 $ — $ — $ 113,000 Non-tradable warrants liability — — — — — — — — Total $ 232,000 $ — $ — $ 232,000 $ 113,000 $ — $ — $ 113,000

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2020
Stock-Based Compensation
Schedule of stock-based compensation expense	Three Months ended June 30, Six Months ended June 30, 2020 2019 2020 2019 General and administrative $ 46,000 $ 67,000 $ 91,000 $ 606,000 Research and development 46,000 88,000 94,000 199,000 $ 92,000 $ 155,000 $ 185,000 $ 805,000
Schedule of stock option activity	Options Outstanding Weighted Weighted- Average Shares Average Remaining Aggregate Available Number of Exercise Contractual Intrinsic for Grant Shares Price Term (in years) Value Balance, December 31, 2019 59,731 994,453 $ 27.37 9.32 $ — Authorized — — Granted (63,250) 63,250 $ 0.307 9.77 Exercised — — $ — Forfeitures 13,112 (13,112) $ 168.21 7.92 Balance, June 30, 2020 9,593 1,044,591 $ 24.08 8.89 $ — Vested or expected to vest, June 30, 2020 1,012,646 $ 89.06 7.60 $ — Exercisable at June 30, 2020 272,982 $ 89.06 7.60 $ —
Schedule of information with respect to stock options outstanding and exercisable	Information with respect to stock options outstanding and exercisable at June 30, 2020 is as follows: Exercise Price Shares Exercisable $0.29 - $0.36 658,250 — $3.39 – $3.72 51,998 9,916 $4.34 – $7.05 269,222 199,860 $16.35 – $97.50 47,897 45,996 $222.00 - $225.00 1,871 1,871 $348.00 – $597.00 4,801 4,800 $651.00 – $1,129.50 3,481 3,468 $1,992.00 - $2,268.00 6,736 6,736 $4,156.50 - $4,371.00 335 335 1,044,591 272,982
Schedule of weighted-average assumptions used for estimating the fair value of the stock compensation granted	Six Months ended June 30, 2020 2019 Risk-free interest rate 0.45 % 2.27 % Expected volatility 105.14 % 83.68 % Expected term 6.00 years 6.25 years Expected dividend yield 0 % 0 % Weighted average grant date fair value $ 0.25 $ 12.60

Nature of Business (Details)

Nature of Business (Details)	Jan. 03, 2020USD ($)shares	Dec. 19, 2019USD ($)shares	Dec. 10, 2019USD ($)shares	Sep. 25, 2019USD ($)shares	Jul. 29, 2016shares	Jan. 05, 2016$ / sharesshares	Aug. 12, 2020USD ($)shares	Nov. 30, 2019USD ($)shares	Jun. 30, 2020USD ($)shares	Jun. 30, 2019USD ($)	Mar. 31, 2019USD ($)	Jun. 30, 2020USD ($)shares	Jun. 30, 2019USD ($)	Dec. 31, 2019USD ($)shares	Jul. 09, 2020$ / sharesshares	Dec. 31, 2018USD ($)
Liquidity
Net loss									$ 7,395,000	$ 3,561,000		$ 12,487,000	$ 11,161,000
Accumulated deficit									415,886,000			415,886,000		$ 403,399,000
Cash and cash equivalents									$ 27,228,000	$ 5,882,000		$ 27,228,000	5,882,000	$ 22,726,000		$ 16,970,000
Common stock outstanding (in shares) | shares									174,177,448			174,177,448		111,167,352
Proceeds from the sale of common stock and warrants, net of costs	$ 9,000,000	$ 4,400,000	$ 4,400,000	$ 3,300,000				$ 9,700,000				$ 9,062,000	391,000
Proceeds from the exercise of warrants												$ 7,298,000	$ 33,000	$ 4,900,000
Proceeds from the exercise of pre-funded warrants														$ 35,000
Issuance of common stock, net (in shares) | shares	27,662,518	13,878,864	14,326,648	2,198,938	239,986	12,912		30,250,000
Stock called by warrants or rights | shares		6,939,432	7,163,324	2,198,938		6,456			35,347,578			35,347,578
Price per share (in dollars per share) | $ / shares						$ 142.50
FTE positions eliminated											6
FTE eliminated positions (as percent of workforce)											24.00%
Severance charge											$ 1,843,000
Non-cash charge, accelerated options											415,000
Subsequent Event
Liquidity
Common stock outstanding (in shares) | shares															174,177,448
Proceeds from the exercise of warrants							$ 2,500,000
Stock called by warrants or rights | shares							9,400,819
Price per share (in dollars per share) | $ / shares															$ 1.44
General and administrative
Liquidity
Severance charge											1,562,000
Research and development
Liquidity
Severance charge											$ 281,000
Pre-funded warrants
Liquidity
Stock called by warrants or rights | shares								24,750,000						23,720,784
Warrants
Liquidity
Stock called by warrants or rights | shares								55,000,000						21,014,378

Summary of Significant Accoun_3

Summary of Significant Accounting Policies - Segment Information (Details)	6 Months Ended
	Jun. 30, 2020segment
Summary of Significant Accounting Policies
Number of operating segments	1

Revenue (Details)

Revenue (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenue
Revenue	$ 56,000	$ 2,022,000	$ 108,000	$ 2,090,000
Deferred revenue
Balance at the beginning of the period			226,000
Balance at the end of the period	226,000		226,000
SymBio
Deferred revenue
Balance at the beginning of the period			3,921,000
Recognition to revenue			112,000
Balance at the end of the period	3,809,000		3,809,000
SymBio | License
Revenue
Revenue	$ 56,000	56,000	112,000	113,000
SymBio | Supplies and other
Revenue
Revenue		1,000	$ (4,000)	12,000
HanX | License
Revenue
Revenue		$ 1,965,000		$ 1,965,000

Net Loss Per Share of Common _3

Net Loss Per Share of Common Stock (Details) - shares	6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares as they would be antidilutive
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares	22,906,780	5,860,516
Warrants
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares as they would be antidilutive
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares	21,862,189	5,504,722
Stock options
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares as they would be antidilutive
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares	1,044,591	355,794

Warrants (Details)

Warrants (Details) - $ / shares	Jan. 03, 2020	Dec. 31, 2019	Dec. 19, 2019	Dec. 10, 2019	Sep. 25, 2019	Jul. 29, 2016	Jan. 05, 2016	Nov. 30, 2019	Jun. 30, 2020	Jul. 29, 2017
Warrants
Warrant exercise price (in dollars per share)						$ 73.80				$ 0.001
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									55,954,486
Warrants Issued (in shares)									1,383,126
Warrants Exercised (in shares)									(35,347,578)
Balance at end of the period (in shares)		55,954,486							21,990,034
Common Stock authorized (in shares)		250,000,000							250,000,000
Issuance of stock (in shares)	27,662,518		13,878,864	14,326,648	2,198,938	239,986	12,912	30,250,000
Non-tradable warrants with exercise price 172.50 Liability
Warrants
Warrant exercise price (in dollars per share)									$ 172.50
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									6,456
Balance at end of the period (in shares)		6,456							6,456
Tradable warrants with exercise price 73.80 Liability
Warrants
Warrant exercise price (in dollars per share)									$ 73.80
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									212,801
Balance at end of the period (in shares)		212,801							212,801
Non-tradable warrants with exercise price 0.15 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.15
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									394
Balance at end of the period (in shares)		394							394
Non-tradable warrants with exercise price 1.60 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 1.60
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									392,834
Balance at end of the period (in shares)		392,834							392,834
Non-tradable warrants with exercise price 14.10 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 14.10
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									5,000
Balance at end of the period (in shares)		5,000							5,000
Non-tradable warrants with exercise price 21.15 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 21.15
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									8,333
Balance at end of the period (in shares)		8,333							8,333
Non-tradable warrants with exercise price 7.7895 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 7.7895
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									15,000
Balance at end of the period (in shares)		15,000							15,000
Non-tradable pre-funded warrants with exercise Price 0.15 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.15
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									52,834
Balance at end of the period (in shares)		52,834							52,834
Non-tradable warrants with exercise price 1.6000 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 1.600
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									1,806,104
Balance at end of the period (in shares)		1,806,104							1,806,104
Non-tradable pre-funded warrants with exercise Price 0.15 Equity1
Warrants
Warrant exercise price (in dollars per share)									$ 0.15
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									74,617
Balance at end of the period (in shares)		74,617							74,617
Non-tradable warrants with exercise price 2.00 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 2
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									109,585
Balance at end of the period (in shares)		109,585							109,585
Non-tradable pre-funded warrants with exercise Price 0.0001 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.0001
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									1,250,000
Warrants Exercised (in shares)									(1,250,000)
Balance at end of the period (in shares)		1,250,000
Non-tradable warrants with exercise price 0.20 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.20
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									41,037,000
Warrants Exercised (in shares)									(29,046,200)
Balance at end of the period (in shares)		41,037,000							11,990,800
Non-tradable warrants with exercise price 0.250 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.250
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									2,521,875
Balance at end of the period (in shares)		2,521,875							2,521,875
Non-tradable warrants with exercise price 0.287 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.287
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									3,581,662
Warrants Exercised (in shares)									(1,581,662)
Balance at end of the period (in shares)		3,581,662							2,000,000
Non-tradable warrants with exercise price 0.43625 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.43625
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									716,332
Balance at end of the period (in shares)		716,332							716,332
Non-tradable warrants with exercise price 0.298 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.298
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									3,469,716
Warrants Exercised (in shares)									(3,469,716)
Balance at end of the period (in shares)		3,469,716
Non-tradable warrants with exercise price 0.45030 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.45030
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)									693,943
Balance at end of the period (in shares)		693,943							693,943
Non-tradable Warrants with Exercise Price 0.45190 Equity
Warrants
Warrant exercise price (in dollars per share)									$ 0.45190
Warrants outstanding and warrant activity
Warrants Issued (in shares)									1,383,126
Balance at end of the period (in shares)									1,383,126

Balance Sheet Detail - Prepaid

Balance Sheet Detail - Prepaid Expenses and Other Current Assets (Details) - USD ($)	Jun. 30, 2020	Dec. 31, 2019
Prepaid expenses and other current assets:
Research and development	$ 281,000	$ 321,000
Manufacturing	70,000	25,000
Insurance	57,000	164,000
Other	312,000	140,000
Prepaid expenses and other current assets	$ 720,000	$ 650,000

Balance Sheet Detail Property a

Balance Sheet Detail Property and Equipment (Details) - USD ($)	Jun. 30, 2020	Dec. 31, 2019
Property and Equipment
Property and equipment	$ 2,298,000	$ 2,283,000
Accumulated depreciation	(2,238,000)	(2,233,000)
Property and equipment, net	$ 60,000	$ 50,000

Balance Sheet Detail - Accrued

Balance Sheet Detail - Accrued Expenses and Other Current Liabilities (Details) - USD ($)	Jun. 30, 2020	Dec. 31, 2019
Balance Sheet Detail
Research and development	$ 2,165,000	$ 2,016,000
Employee compensation	977,000	1,537,000
Professional fees	235,000	242,000
Accrued expenses and other current liabilities:	$ 3,377,000	$ 3,795,000

Fair Value Measurements (Detail

Fair Value Measurements (Details) - USD ($)	Jan. 03, 2020	Dec. 19, 2019	Dec. 10, 2019	Sep. 25, 2019	Jul. 29, 2016	Jan. 05, 2016	Nov. 30, 2019	Jun. 30, 2020	Dec. 31, 2019
Sale of Securities
Issuance of common stock, net (in shares)	27,662,518	13,878,864	14,326,648	2,198,938	239,986	12,912	30,250,000
Price per share (in dollars per share)						$ 142.50
Stock called by warrants or rights		6,939,432	7,163,324	2,198,938		6,456		35,347,578
Proceeds from issuance or sale of equity						$ 1,840,000
Estimated fair value using the Black-Scholes pricing model								$ 0	$ 0
Pre-funded warrants
Sale of Securities
Stock called by warrants or rights							24,750,000		23,720,784

Fair Value Measurements - Right

Fair Value Measurements - Rights Offering (Details) - $ / shares	Jan. 03, 2020	Dec. 19, 2019	Dec. 10, 2019	Sep. 25, 2019	Jul. 29, 2016	Jan. 05, 2016	Nov. 30, 2019	Jul. 29, 2017
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)	27,662,518	13,878,864	14,326,648	2,198,938	239,986	12,912	30,250,000
Rights or warrants issued (in shares)					212,801
Exercise price (in dollars per share)					$ 73.80			$ 0.001
Class Of Warrant Or Right Initially Exercisable Term					5 years
Redemption period (in years)					1 year
Volume weighted average price per share of common stock (in dollars per share)					$ 184.50
Threshold consecutive trading days (in days)					10 days
Pre-funded warrants
Subsidiary, Sale of Stock [Line Items]
Rights or warrants issued (in shares)					43,760

Fair Value Measurements - Weigh

Fair Value Measurements - Weighted-average assumptions (Details)	Jun. 30, 2020Y
Risk-free interest rate | Pre-funded warrants
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	0.16
Expected volatility | Pre-funded warrants
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	105.44
Expected term
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	1.08
Expected dividend yield | Pre-funded warrants
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	0

Fair Value Measurements - Fair

Fair Value Measurements - Fair Value Hierarchy Table (Details) - USD ($)	Jun. 30, 2020	Dec. 31, 2019
Liabilities measured at fair value
Warrant liability	$ 232,000	$ 113,000
Recurring basis
Liabilities measured at fair value
Total	232,000	113,000
Recurring basis | Tradable warrants liability
Liabilities measured at fair value
Warrant liability	232,000	113,000
Recurring basis | Level 1
Liabilities measured at fair value
Total	232,000	113,000
Recurring basis | Level 1 | Tradable warrants liability
Liabilities measured at fair value
Warrant liability	$ 232,000	$ 113,000

Fair Value Measurements - Trans

Fair Value Measurements - Transfers (Details)	Jun. 30, 2020USD ($)
Fair Value Measurements
Amount of transfers of assets out of Level 1 into Level 2	$ 0
Amount of transfers of assets out of Level 2 into Level 1	0
Amount of transfers of liabilities out of Level 1 into Level 2	0
Amount of transfers of liabilities out of Level 2 into Level 1	$ 0

Stock-Based Compensation (Detai

Stock-Based Compensation (Details) - shares	Jun. 17, 2019	Jun. 30, 2020	Dec. 31, 2019	Jun. 27, 2018	Jul. 31, 2013
2013 Plan
Stock-Based Compensation
Shares authorized (in shares)					40,718
Evergreen provision (percent)					4.00%
Evergreen provision, shares ( in shares)					13,333
2013 Plan | Common Stock
Stock-Based Compensation
Shares authorized (in shares)				2,354
2018 Plan
Stock-Based Compensation
Shares authorized (in shares)				402,354
Additional shares authorized (in shares)	589,500
2018 Plan | Common Stock
Stock-Based Compensation
Shares authorized (in shares)				400,000
Stock options
Stock-Based Compensation
Common Stock available for future issuance (in shares)		9,593	59,731

Stock-Based Compensation - Expe

Stock-Based Compensation - Expense (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Stock-Based Compensation
Net tax benefits related to the stock-based compensation costs			$ 0
Total stock-based compensation	$ 92,000	$ 155,000	185,000	$ 805,000
General and administrative
Stock-Based Compensation
Total stock-based compensation	46,000	67,000	91,000	606,000
Research and development
Stock-Based Compensation
Total stock-based compensation	$ 46,000	$ 88,000	$ 94,000	$ 199,000

Stock-Based Compensation - Acti

Stock-Based Compensation - Activity (Details) - Stock options - $ / shares	6 Months Ended	12 Months Ended
	Jun. 30, 2020	Dec. 31, 2019
Shares Available for Grant
Balance at the beginning of the period (in shares)	59,731
Granted (in shares)	(63,250)
Forfeitures (in shares)	13,112
Balance at the end of the period (in shares)	9,593	59,731
Number of Shares
Balance at the beginning of the period (in shares)	994,453
Granted (in shares)	63,250
Forfeitures (in shares)	(13,112)
Cancelled (in shares)	(13,112)
Balance at the end of the period (in shares)	1,044,591	994,453
Vested or expected to vest at the end of the period (in shares)	1,012,646
Exercisable at the end of the period (in shares)	272,982
Weighted-Average Exercise Price
Balance at the beginning of the period (in dollars per share)	$ 27.37
Granted (in dollars per share)	0.307
Forfeitures (in dollars per share)	168.21
Balance at the end of the period (in dollars per share)	24.08	$ 27.37
Vested or expected to vest at the end of the period (in dollars per share)	89.06
Exercisable at the end of the period (in dollars per share)	$ 89.06
Additional Disclosures
Weighted average remaining contractual term	8 years 10 months 21 days	9 years 3 months 26 days
Weighted average remaining contractual term of options forfeitures	7 years 11 months 1 day
Weighted average remaining contractual term of options granted	9 years 9 months 7 days
Weighted average remaining contractual term of options vested or expected to vest	7 years 7 months 6 days
Weighted average remaining contractual term of options exercisable	7 years 7 months 6 days

Stock-Based Compensation - Outs

Stock-Based Compensation - Outstanding and Exercisable (Details)	6 Months Ended
	Jun. 30, 2020$ / sharesshares
Stock options
Share-Based Compensation
Shares (in shares)	1,044,591
Exercisable (in shares)	272,982
Exercise Price Range $0.30 - $0.31 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 0.29
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 0.36
Shares (in shares)	658,250
Exercise Price Range $3.39 - $3.72 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 3.39
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 3.72
Shares (in shares)	51,998
Exercisable (in shares)	9,916
Exercise Price Range $4.34 - $7.05 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 4.34
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 7.05
Shares (in shares)	269,222
Exercisable (in shares)	199,860
Exercise Price Range $16.35 - $97.50 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 16.35
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 97.50
Shares (in shares)	47,897
Exercisable (in shares)	45,996
Exercise Price Range $222.00 - $225.00 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 222
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 225
Shares (in shares)	1,871
Exercisable (in shares)	1,871
Exercise Price Range $348.00 - $597.00 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 348
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 597
Shares (in shares)	4,801
Exercisable (in shares)	4,800
Exercise Price Range $651.00 - $1,129.50 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 651
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 1,129.50
Shares (in shares)	3,481
Exercisable (in shares)	3,468
Exercise Price Range $1,992.00 - $2,268.00 | Stock options
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 1,992
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 2,268
Shares (in shares)	6,736
Exercisable (in shares)	6,736
Exercise Price Range $4,156.50 - $4,371.00
Share-Based Compensation
Exercise price, lower range limit (in dollars per share) | $ / shares	$ 4,156.50
Exercise price, upper range limit (in dollars per share) | $ / shares	$ 4,371
Exercise Price Range $4,156.50 - $4,371.00 | Stock options
Share-Based Compensation
Shares (in shares)	335
Exercisable (in shares)	335

Stock-Based Compensation - Unre

Stock-Based Compensation - Unrecognized Compensation Expense (Details) - Stock options	6 Months Ended
	Jun. 30, 2020USD ($)
Stock-Based Compensation
Unrecognized compensation expense related to unvested stock options	$ 525,000
Weighted-average period for recognizing unrecognized compensation expense related to unvested stock options (in years)	2 years 1 month 13 days

Stock-Based Compensation - Fair

Stock-Based Compensation - Fair Value Assumptions (Details) - $ / shares	6 Months Ended		12 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Dec. 31, 2020	Dec. 31, 2019
Assumptions used
Expected dividend yield (as a percent)	0.00%
Stock options
Assumptions used
Risk-free interest rate (as a percent)	0.45%	2.27%
Expected volatility (as a percent)	105.14%	83.68%
Expected term (in years)	6 years	6 years 3 months
Expected dividend yield (as a percent)	0.00%	0.00%
Weighted average grant date fair value (in dollars per share)	$ 0.25	$ 12.60
Annualized forfeiture rate (as a percent)			4.14%	4.14%

Research Agreements (Details)

Research Agreements (Details)	6 Months Ended
	Jun. 30, 2020USD ($)
License
Research Agreements
Revenue	$ 0

License and Collaboration Agr_2

License and Collaboration Agreements (Details) - USD ($)	Jan. 03, 2020	Dec. 19, 2019	Dec. 10, 2019	Sep. 25, 2019	May 15, 2019	May 10, 2019	Jul. 29, 2016	Jan. 05, 2016	Dec. 31, 2019	Nov. 30, 2019	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
License and collaboration agreements
Issuance of common stock, net (in shares)	27,662,518	13,878,864	14,326,648	2,198,938			239,986	12,912		30,250,000
Value of common stock												$ 392,000	$ 9,062,000	$ 392,000
Research and development											$ 4,801,000	3,895,000	$ 8,171,000	7,969,000
License and collaboration agreements | HanX
License and collaboration agreements
Committed amount						$ 4,000,000
Collaborative Arrangement upfront fees												2,000,000
Collaboration revenue						2,000,000
Issuance of common stock, net (in shares)					103,520
Escrow Deposit						2,000,000
Potential milestone payments						45,500,000
Revenue												1,700,000
Receivable recorded												1,700,000		1,700,000
Value of common stock					$ 500,000	$ 2,000,000
Redemption premium					$ 100,000				$ 200,000
Reversal of revenue recognized									$ 200,000
License and collaboration agreements | HanX | Other Current Assets [Member]
License and collaboration agreements
Receivable recorded												$ 200,000		$ 200,000

Related-Party Transactions (Det

Related-Party Transactions (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019	Dec. 31, 2019
Member of board of directors
Related-Party Transactions
Payments to related party	$ 33,000	$ 33,000	$ 66,000	$ 66,000
Amounts due to related party	33,000		33,000		$ 33,000
Significant shareholder
Related-Party Transactions
Payments to related party	77,000	$ 88,000	201,000	$ 175,000
Amounts due to related party	$ 77,000		$ 77,000		$ 150,000

Securities Registrations and _2

Securities Registrations and Sales Agreements - Underwriting agreement with HCW (Details) - USD ($)	Jan. 03, 2020	Dec. 31, 2019	Dec. 19, 2019	Dec. 10, 2019	Sep. 25, 2019	Jul. 29, 2016	Jan. 05, 2016	Jan. 31, 2020	Nov. 30, 2019	Jul. 29, 2017
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)	27,662,518		13,878,864	14,326,648	2,198,938	239,986	12,912		30,250,000
Warrant exercise price (in dollars per share)						$ 73.80				$ 0.001
HCW
Subsidiary, Sale of Stock [Line Items]
Warrant exercise price (in dollars per share)		$ 0.4519
Percentage of cash fees on gross proceeds		7.00%
Percentage of management fees on gross proceeds		1.00%
Payment of Non-accountable Expenses		$ 85,000
Payment of Clearing Fees		$ 10,000
Warrants issued to purchase of common stock		1,383,126
Proceeds from issuance of warrants								$ 9,000,000
The Offering | Certain institutional and accredited investors
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)		27,662,518
The Offering | Certain institutional and accredited investors | Common Stock Warrants
Subsidiary, Sale of Stock [Line Items]
Warrant exercise price (in dollars per share)		$ 0.3615

Subsequent Event - (Details)

Subsequent Event - (Details) - USD ($)	Jul. 09, 2020	Aug. 12, 2020	Jun. 30, 2020	Jun. 30, 2019	Dec. 31, 2019	Dec. 19, 2019	Dec. 10, 2019	Sep. 25, 2019	Jan. 05, 2016
Subsequent Event
Share Price									$ 142.50
Common stock outstanding (in shares)			174,177,448		111,167,352
Proceeds from Warrant Exercises			$ 7,298,000	$ 33,000	$ 4,900,000
Number of securities to each class of warrant (in shares)			35,347,578			6,939,432	7,163,324	2,198,938	6,456
Subsequent Event
Subsequent Event
Share Price	$ 1.44
Common stock outstanding (in shares)	174,177,448
Market capitalization	$ 250
Proceeds from Warrant Exercises		$ 2,500,000
Number of securities to each class of warrant (in shares)		9,400,819
Share Based Compensation Arrangement By Share Based Payment Award for Cash Payment Of Each SAR	$ 0.88
Subsequent Event | PSU awards
Subsequent Event
Stock option grants	1,863,300
Subsequent Event | SAR awards
Subsequent Event
Stock option grants	3,850,700
Share base amount (per share)	$ 0.56
Subsequent Event | Non employee directors | SAR awards
Subsequent Event
Number of awards issued	125,000
Subsequent Event | Vesting Percentage One | PSU awards
Subsequent Event
Vesting (Percentage)	50.00%
Subsequent Event | Vesting Percentage One | SAR awards
Subsequent Event
Vesting (Percentage)	33.00%
Subsequent Event | Vesting Percentage Two | PSU awards
Subsequent Event
Vesting (Percentage)	50.00%
Subsequent Event | Vesting Percentage Two | SAR awards
Subsequent Event
Vesting (Percentage)	67.00%