Itaú Unibanco Holding (ITUB) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	38	255	SH		DFND		0	0	255
908 DEVICES INC	COM	65443P102	48	1,860	SH		DFND		0	0	1,860
A10 NETWORKS INC	COM	002121101	55	3,317	SH		DFND		0	0	3,317
ABBVIE INC	COM	00287Y109	86	630	SH		DFND		0	0	630
ACCELERATE DIAGNOSTICS INC	COM	00430H102	30	5,895	SH		DFND		0	0	5,895
ACTIVISION BLIZZARD INC	COM	00507V109	438	6,485	SH		DFND		0	0	6,485
ACUITY BRANDS INC	COM	00508Y102	15	71	SH		DFND		0	0	71
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	51	13,087	SH		DFND		0	0	13,087
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	8	280	SH		DFND		0	0	280
ADOBE SYSTEMS INCORPORATED	COM	00724F101	227	397	SH		DFND		0	0	397
ADVANCED DRAIN SYS INC DEL	COM	00790R104	18	137	SH		DFND		0	0	137
ADVANCED MICRO DEVICES INC	COM	007903107	144	1,000	SH		DFND		0	0	1,000
ADVENT TECHNOLOGIES HOLDNG I	COM CL A	00788A105	55	7,746	SH		DFND		0	0	7,746
AERCAP HOLDINGS NV	SHS	N00985106	144	2,204	SH		DFND		0	0	2,204
AEVA TECHNOLOGIES INC	COM	00835Q103	40	5,162	SH		DFND		0	0	5,162
AFYA LTD	CL A COM	G01125106	13,824	911,298	SH		DFND		73,239	0	838,059
AGILENT TECHNOLOGIES INC	COM	00846U101	178	1,108	SH		DFND		0	0	1,108
AGILYSYS INC	COM	00847J105	46	1,049	SH		DFND		0	0	1,049
AIR PRODS & CHEMS INC	COM	009158106	215	706	SH		DFND		0	0	706
AIRBNB INC	COM	009066101	28	163	SH		DFND		0	0	163
ALIBABA GROUP HLDG LTD	SPONSORED ADS	01609W102	15,566	126,562	SH		DFND		0	0	126,562
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	170	996	SH		DFND		0	0	996
ALPHABET INC	CAP STK CL A	02079K305	26,350	9,013	SH		DFND		148	0	8,865
ALPHABET INC	CAP STK CL C	02079K107	20,639	7,068	SH		DFND		0	0	7,068
AMAZON COM INC	COM	023135106	29,645	8,797	SH		DFND		695	0	8,102
AMBARELLA INC	SHS	G037AX101	46	231	SH		DFND		0	0	231
AMBEV SA	SPONSORED ADR	02319V103	32,368	11,754,196	SH		DFND		144,600	0	11,609,596
AMCOR PLC	ORD	G0250X107	0	1	SH		DFND		0	0	1
AMERICA MOVIL SAB DE CV	SPON ADR L SHS	02364W105	72,690	3,517,728	SH		DFND		390,936	0	3,126,792
AMERICAN WTR WKS CO INC NEW	COM	030420103	67	354	SH		DFND		0	0	354
AMGEN INC	COM	031162100	82	360	SH		DFND		0	0	360
ANALOG DEVICES INC	COM	032654105	72	412	SH		DFND		0	0	412
ANTHEM INC	COM	036752103	21	46	SH		DFND		0	0	46
APELLIS PHARMACEUTICALS INC	COM	03753U106	8	163	SH		DFND		0	0	163
APPLE INC	COM	037833100	16,366	91,842	SH		DFND		483	0	91,359
ARCTURUS THERAPEUTICS HLDGS	COM	03969T109	50	1,274	SH		DFND		0	0	1,274
ARENA PHARMACEUTICALS INC	COM NEW	040047607	23	249	SH		DFND		0	0	249
ARMSTRONG WORLD INDS INC NEW	COM	04247X102	13	112	SH		DFND		0	0	112
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	15	228	SH		DFND		0	0	228
ASANA INC	CL A	04342Y104	48	626	SH		DFND		0	0	626
ASE TECHNOLOGY HOLDING CO LT	SPONSORED ADS	00215W100	3,621	34,000	SH		DFND		34,000	0	0
ASENSUS SURGICAL INC COM	COM	04367G103	38	35,547	SH		DFND		0	0	35,547
ASML HOLDING N V	N Y REGISTRY SHS	N07059210	398	500	SH		DFND		0	0	500
ASTRAZENECA PLC	SPONSORED ADR	046353108	4,290	73,643	SH		DFND		0	0	73,643
AUTONATION INC	COM	05329W102	103	891	SH		DFND		0	0	891
BAIDU INC	SPON ADR REP A	056752108	16,380	108,757	SH		DFND		0	0	108,757
BALLARD PWR SYS INC NEW	COM	058586108	191	15,108	SH		DFND		0	0	15,108
BANCO BRADESCO S A	SP ADR PFD NEW	059460303	87,353	26,069,330	SH		DFND		4,256,676	0	21,812,654
BANCO DE CHILE	SPONSORED ADS	059520106	7,571	481,892	SH		DFND		0	0	481,892
BANCO SANTANDER BRASIL S A	ADS REP 1 UNIT	05967A107	1,350	251,400	SH		DFND		0	0	251,400
BANCO SANTANDER CHILE NEW	SP ADR REP COM	05965X109	3,188	222,534	SH		DFND		0	0	222,534
BANCOLOMBIA S A	SPON ADR PREF	05968L102	16,709	528,933	SH		DFND		0	0	528,933
BANK AMER CORP	PUT	060505954	360	2,500	SH	Put	DFND		0	0	2,500
BEAM THERAPEUTICS INC	COM	07373V105	91	1,110	SH		DFND		0	0	1,110
BEST BUY INC	COM	086516101	5,562	54,740	SH		DFND		54,740	0	0
BEYOND MEAT INC	COM	08862E109	11	161	SH		DFND		0	0	161
BIGCOMMERCE HLDGS INC	COM SER 1	08975P108	42	1,170	SH		DFND		0	0	1,170
BIO TECHNE CORP	COM	09073M104	185	363	SH		DFND		0	0	363
BIOGEN INC	COM	09062X103	78	327	SH		DFND		0	0	327
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	77	869	SH		DFND		0	0	869
BIT MINING LIMITED	SPON ADR REP A	055474100	47	7,328	SH		DFND		0	0	7,328
BLOOM ENERGY CORP	COM CL A	093712107	154	7,047	SH		DFND		0	0	7,047
BOEING CO	COM	097023105	283,752	1,400	SH		SOLE		1,400	0	0
BOOKING HOLDINGS INC	COM	09857L108	3,158	1,318	SH		DFND		0	0	1,318
BORGWARNER INC	COM	099724106	12	269	SH		DFND		0	0	269
BOSTON PROPERTIES INC	COM	101121101	27	235	SH		DFND		0	0	235
BP PLC	SPONSORED ADR	055622104	1,663	62,300	SH		DFND		0	0	62,300
BRISTOL MYERS SQUIBB CO	COM	110122108	83	1,333	SH		DFND		0	0	1,333
BROADCOM INC	COM	11135F101	169	254	SH		DFND		0	0	254
BRUKER CORP	COM	116794108	34	400	SH		DFND		0	0	400
BUTTERFLY NETWORK INC	COM CL A	124155102	44	6,492	SH		DFND		0	0	6,492
C3 AI INC	CL A	12468P104	48	1,475	SH		DFND		0	0	1,475
CANAAN INC	SPONSORED ADS	134748102	40	7,918	SH		DFND		0	0	7,918
CANADIAN PAC RY LTD	COM	13645T100	72	1,006	SH		DFND		0	0	1,006
CAPITAL ONE FINL CORP	COM	14040H105	146	1,001	SH		DFND		0	0	1,001
CATALENT INC	COM	148806102	101	785	SH		DFND		0	0	785
CATHAY GEN BANCORP	COM	149150104	5,063	81,000	SH		DFND		81,000	0	0
CBRE GROUP INC	CL A	12504L109	82	752	SH		DFND		0	0	752
CEMEX SAB DE CV	SPON ADR NEW	151290889	112,524	17,099,973	SH		DFND		1,574,144	0	15,525,829
CHARGEPOINT HOLDINGS INC	COM CL A	15961R105	46	2,389	SH		DFND		0	0	2,389
CHART INDS INC	COM PAR $0.01	16115Q308	186	1,171	SH		DFND		0	0	1,171
CHARTER COMMUNICATIONS INC N	CL A	16119P108	74	113	SH		DFND		0	0	113
CHEMOURS CO	COM	163851108	179	5,382	SH		DFND		0	0	5,382
CHEVRON CORP NEW	COM	166764100	31,706	270,000	SH		DFND		0	0	270,000
CISCO SYS INC	COM	17275R102	2,433	38,377	SH		DFND		34,500	0	3,877
CISCO SYS INC	PUT	17275R952	322	2,500	SH	Put	DFND		0	0	2,500
CITRIX SYS INC	COM	177376100	49	514	SH		DFND		0	0	514
CLEAN HARBORS INC	COM	184496107	11	112	SH		DFND		0	0	112
COCA COLA CO	COM	191216100	67	1,142	SH		DFND		0	0	1,142
COINBASE GLOBAL INC	COM CL A	19260Q107	535	2,120	SH		DFND		2,120	0	0
COMCAST CORP NEW	CL A	20030N101	93	1,834	SH		DFND		0	0	1,834
COMPANHIA BRASILEIRA DE DIST	SPONSORED ADR	20440T300	486	124,042	SH		DFND		0	0	124,042
COMPANIA DE MINAS BUENAVENTU	SPONSORED ADR	204448104	6,803	929,362	SH		DFND		0	0	929,362
CONSOLIDATED EDISON INC	COM	209115104	34	395	SH		DFND		0	0	395
CORTEVA INC	COM	22052L104	174	3,697	SH		DFND		0	0	3,697
COSTCO WHSL CORP NEW	COM	22160K105	12,579	22,306	SH		DFND		0	0	22,306
CREDICORP LTD	COM	G2519Y108	136,823	1,140,583	SH		DFND		63,962	0	1,076,621
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	154	1,954	SH		DFND		0	0	1,954
CUMMINS INC	COM	231021106	197	904	SH		DFND		0	0	904
CYTOKINETICS INC	COM NEW	23282W605	9	207	SH		DFND		0	0	207
D R HORTON INC	COM	23331A109	158	1,467	SH		DFND		0	0	1,467
DANAHER CORP DEL	COM	235851102	378	1,150	SH		DFND		0	0	1,150
DARLING INGREDIENTS INC	COM	237266101	25	365	SH		DFND		0	0	365
DENALI THERAPEUTICS INC	COM	24823R105	88	1,948	SH		DFND		0	0	1,948
DESKTOP METAL INC	COM CL A	25058X105	41	8,058	SH		DFND		0	0	8,058
DISCOVER FINL SVCS	COM	254709108	153	1,320	SH		DFND		0	0	1,320
DISNEY WALT CO	COM DISNEY	254687106	612	3,941	SH		DFND		2,387	0	1,554
DOLLAR GEN CORP NEW	COM	256677105	22	93	SH		DFND		0	0	93
DOORDASH INC	CL A	25809K105	70	457	SH		DFND		0	0	457
DOVER CORP	COM	260003108	68	375	SH		DFND		0	0	375
DROPBOX INC	CL A	26210C104	50	2,032	SH		DFND		0	0	2,032
DUPONT DE NEMOURS INC	COM	26614N102	11	132	SH		DFND		0	0	132
EATON CORP PLC	SHS	G29183103	86	501	SH		DFND		0	0	501
EBANG INTL HLDGS INC	CL A SHS	G3R33A106	34	35,050	SH		DFND		0	0	35,050
EBAY INC	COM	278642103	29	431	SH		DFND		0	0	431
ECOPETROL S A	SPONSORED ADS	279158109	9,986	774,678	SH		DFND		0	0	774,678
EDITAS MEDICINE INC	COM	28106W103	11	388	SH		DFND		0	0	388
EDWARDS LIFESCIENCES CORP	COM	28176E108	84	643	SH		DFND		0	0	643
ELECTRAMECCANICA VEHS CORP	COM NEW	284849205	42	17,464	SH		DFND		0	0	17,464
ELECTRONIC ARTS INC	COM	285512109	249	1,855	SH		DFND		0	0	1,855
ENERGY RECOVERY INC	COM	29270J100	50	2,344	SH		DFND		0	0	2,344
ENERGY TRANSFER EQUITY L P	COM UT LTD PTN	29273V100	40	4,922	SH		DFND		0	0	4,922
ENTEGRIS INC	COM	29362U104	49	357	SH		DFND		0	0	357
EOG RES INC	COM	26875P101	151	1,697	SH		DFND		0	0	1,697
EOS ENERGY ENTERPRISES INC	COM CL A	29415C101	45	5,788	SH		DFND		0	0	5,788
EPAM SYS INC	COM	29414B104	201	300	SH		DFND		0	0	300
ESSENTIAL UTILS INC	COM	29670G102	17	313	SH		DFND		0	0	313
EXACT SCIENCES CORP	COM	30063P105	49	633	SH		DFND		0	0	633
EXELIXIS INC	COM	30161Q104	105	5,618	SH		DFND		0	0	5,618
EXXON MOBIL CORP	COM	30231G102	17,964	295,506	SH		DFND		0	0	295,506
FACEBOOK INC	CL A	30303M102	56,170	165,440	SH		DFND		100,000	0	65,440
FACEBOOK INC	PUT	30303M952	388	1,000	SH	Put	DFND		0	0	1,000
FATE THERAPEUTICS INC	COM	31189P102	17	283	SH		DFND		0	0	283
FIDELITY NATL INFORMATION SV	COM	31620M106	21	195	SH		DFND		0	0	195
FIRST SOLAR INC	COM	336433107	23	262	SH		DFND		0	0	262
FISERV INC	COM	337738108	24	228	SH		DFND		0	0	228
FOMENTO ECONOMICO MEXICANO S	SPON ADR UNITS	344419106	96,962	1,285,157	SH		DFND		112,961	0	1,172,196
FOOT LOCKER INC	COM	344849104	93	2,116	SH		DFND		0	0	2,116
FORD MTR CO DEL	COM PAR $0.01	345370860	0	1	SH		DFND		0	0	1
FREEPORT-MCMORAN INC	CL B	35671D857	12,320	296,000	SH		DFND		0	0	296,000
FUELCELL ENERGY INC	COM	35952H601	122	22,900	SH		DFND		0	0	22,900
GENERAL MLS INC	COM	370334104	19	282	SH		DFND		0	0	282
GENERAL MTRS CO	COM	37045V100	198	3,406	SH		DFND		0	0	3,406
GENUINE PARTS CO	COM	372460105	69	493	SH		DFND		0	0	493
GEOPARK LTD	USD SHS	G38327105	3,840	335,387	SH		DFND		0	0	335,387
GERDAU SA	SPON ADR REP PFD	373737105	48,378	10,036,257	SH		DFND		911,085	0	9,125,172
GILEAD SCIENCES INC	COM	375558103	325	4,468	SH		DFND		3,367	0	1,101
GLOBAL X FDS	LITHIUM BTRY ETF	37954Y855	6,199	73,000	SH		DFND		0	0	73,000
GLOBANT S A	COM	L44385109	11,148	38,637	SH		DFND		0	0	38,637
GOLDMAN SACHS GROUP INC	COM	38141G104	146	378	SH		DFND		0	0	378
GRAPHIC PACKAGING HLDG CO	COM	388689101	13	664	SH		DFND		0	0	664
GRITSTONE ONCOLOGY INC	COM	39868T105	53	4,058	SH		DFND		0	0	4,058
GRUPO AEROPORTUARIO DEL CENT	SPON ADR	400501102	3,808	71,058	SH		DFND		2,851	0	68,207
GRUPO AEROPORTUARIO DEL SURE	SPON ADR SER B	40051E202	25,174	124,230	SH		DFND		13,371	0	110,859
GRUPO AVAL ACCIONES Y VALORE	SPONSORED ADS	40053W101	3,196	625,476	SH		DFND		0	0	625,476
GRUPO TELEVISA SA	SPON ADR REP ORD	40049J206	9,019	964,872	SH		DFND		124,083	0	840,789
GUARDANT HEALTH INC	COM	40131M109	130	1,293	SH		DFND		0	0	1,293
HALLIBURTON CO	COM	406216101	133	5,855	SH		DFND		0	0	5,855
HASBRO INC	COM	418056107	127	1,260	SH		DFND		0	0	1,260
HDFC BANK LTD	ADR REPS 3 SHS	40415F101	410	6,300	SH		DFND		0	0	6,300
HEWLETT PACKARD ENTERPRISE C	COM	42824C109	62	3,916	SH		DFND		0	0	3,916
HEXCEL CORP NEW	COM	428291108	11	221	SH		DFND		0	0	221
HOLOGIC INC	COM	436440101	35	461	SH		DFND		0	0	461
HONEYWELL INTL INC	COM	438516106	63	306	SH		DFND		0	0	306
HORIZON THERAPEUTICS PUB L	SHS	G46188101	45	419	SH		DFND		0	0	419
HP INC	COM	40434L105	0	1	SH		DFND		0	0	1
HUMANA INC	COM	444859102	21	44	SH		DFND		0	0	44
HYSTER YALE MATLS HANDLING I	CL A	449172105	90	2,210	SH		DFND		0	0	2,210
IDACORP INC	COM	451107106	12	108	SH		DFND		0	0	108
ILLUMINA INC	COM	452327109	181	472	SH		DFND		0	0	472
IMMUNITYBIO INC	COM	45256X103	51	7,943	SH		DFND		0	0	7,943
INCYTE CORP	COM	45337C102	111	1,503	SH		DFND		0	0	1,503
INFOSYS LTD	SPONSORED ADR	456788108	679	26,811	SH		DFND		0	0	26,811
INOVIO PHARMACEUTICALS INC	COM NEW	45773H201	39	7,548	SH		DFND		0	0	7,548
INTEGRA LIFESCIENCES HLDGS C	COM NEW	457985208	17	243	SH		DFND		0	0	243
INTELLIA THERAPEUTICS INC	COM	45826J105	127	1,045	SH		DFND		0	0	1,045
INTERCONTINENTAL EXCHANGE IN	COM	45866F104	8,288	60,592	SH		DFND		0	0	60,592
INTL PAPER CO	COM	460146103	38	810	SH		DFND		0	0	810
INTRA CELLULAR THERAPIES INC	COM	46116X101	6	112	SH		DFND		0	0	112
INTUITIVE SURGICAL INC	COM NEW	46120E602	82	225	SH		DFND		0	0	225
INVITAE CORP	COM	46185L103	11	678	SH		DFND		0	0	678
IONIS PHARMACEUTICALS INC	COM	462222100	86	2,804	SH		DFND		0	0	2,804
IQVIA HLDGS INC	COM	46266C105	106	374	SH		DFND		0	0	374
ISHARES INC	MSCI BRAZIL ETF	464286400	9,734	348,250	SH		DFND		0	0	348,250
ISHARES INC	MSCI HONG KG ETF	464286871	821	35,400	SH		DFND		0	0	35,400
ISHARES INC	MSCI JPN ETF NEW	46434G822	61,467	918,025	SH		DFND		836,105	0	81,920
ISHARES INC	MSCI TAIWAN ETF	46434G772	1,865	28,000	SH		DFND		0	0	28,000
ISHARES INC	PUT	464286950	3,158	5,000	SH	Put	DFND		0	0	5,000
ISHARES INC	PUT	464286951	100	2,500	SH	Put	DFND		0	0	2,500
ISHARES INC	PUT	46434G952	373	1,500	SH	Put	DFND		0	0	1,500
ISHARES INC	MSCI PAC JP ETF	464286665	326	6,800	SH		DFND		0	0	6,800
ISHARES INC	MSCI CDA ETF	464286509	3,759	98,270	SH		DFND		0	0	98,270
ISHARES INC	MSCI STH KOR ETF	464286772	1,915	24,500	SH		DFND		0	0	24,500
ISHARES INC	CORE MSCI EMKT	46434G103	648	10,800	SH		DFND		0	0	10,800
ISHARES INC	MSCI EM ASIA ETF	464286426	1,567	19,000	SH		DFND		0	0	19,000
ISHARES INC	MSCI GERMANY ETF	464286806	34	1,032	SH		DFND		0	0	1,032
ISHARES INC	JP MRG EM CRP BD	464286251	6,962	136,500	SH		DFND		136,500	0	0
ISHARES TR	CHINA LG-CAP ETF	464287184	15,239	416,565	SH		DFND		0	0	416,565
ISHARES TR	MSCI EAFE ETF	464287465	4,119	52,350	SH		DFND		0	0	52,350
ISHARES TR	MSCI EMG MKT ETF	464287234	25,251	516,900	SH		DFND		200,100	0	316,800
ISHARES TR	PUT	464287956	466	3,500	SH	Put	DFND		0	0	3,500
ISHARES TR	PUT	464287955	848	6,670	SH	Put	DFND		0	0	6,670
ISHARES TR	PUT	464287954	2,334	19,000	SH	Put	DFND		0	0	19,000
ISHARES TR	RUSSELL 2000 ETF	464287655	3,103	13,951	SH		DFND		0	0	13,951
ISHARES TR	MSCI ACWI ETF	464288257	4,609	43,500	SH		DFND		0	0	43,500
ISHARES TR	MSCI CHINA ETF	46429B671	3,031	48,000	SH		DFND		0	0	48,000
ISHARES TR	JPMORGAN USD EMG	464288281	5,128	47,000	SH		DFND		32,000	0	15,000
ISHARES TR	IBOXX HI YD ETF	464288513	6,265	72,000	SH		DFND		72,000	0	0
ISHARES TR	IBOXX INV CP ETF	464287242	6,387	48,198	SH		DFND		48,198	0	0
ISHARES TR	S&P 500 VAL ETF	464287408	4,624	29,500	SH		DFND		0	0	29,500
ISHARES TR	SHORT TREAS BD	464288679	313	2,836	SH		DFND		2,836	0	0
ISHARES TR	10-20 YR TRS ETF	464288653	4,558	30,716	SH		DFND		30,716	0	0
ISHARES TR	US TREAS BD ETF	46429B267	3,737	140,073	SH		DFND		140,073	0	0
ISHARES TR	MSCI INDIA ETF	46429B598	4,128	90,050	SH		DFND		0	0	90,050
ISHARES TR	RUS 1000 VAL ETF	464287598	132	785	SH		DFND		0	0	785
ISHARES TR	EUROPE ETF	464287861	1,197	22,000	SH		DFND		0	0	22,000
ITAU UNIBANCO HLDG S A	SPON ADR REP PFD	465562106	77,200	21,006,360	SH		DFND		2,319,495	0	18,686,865
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	78	609	SH		DFND		0	0	609
JEFFERIES FINL GROUP INC	COM	47233W109	119	3,059	SH		DFND		0	0	3,059
JOHNSON & JOHNSON	COM	478160104	623	3,634	SH		DFND		2,222	0	1,412
JOHNSON CTLS INTL PLC	SHS	G51502105	78	969	SH		DFND		0	0	969
JPMORGAN CHASE & CO	COM	46625H100	30,467	192,243	SH		DFND		0	0	192,243
JUNIPER NETWORKS INC	COM	48203R104	55	1,546	SH		DFND		0	0	1,546
KEYSIGHT TECHNOLOGIES INC	COM	49338L103	71	342	SH		DFND		0	0	342
KKR & CO INC	CL A	48251W104	8,411	112,498	SH		DFND		0	0	112,498
L3HARRIS TECHNOLOGIES INC	COM	502431109	65	304	SH		DFND		0	0	304
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	242	773	SH		DFND		0	0	773
LAM RESEARCH CORP	COM	512807108	20	28	SH		DFND		0	0	28
LENDINGCLUB CORP	COM NEW	52603A208	39	1,580	SH		DFND		0	0	1,580
LENNAR CORP	CL A	526057104	154	1,337	SH		DFND		0	0	1,337
LILLY ELI & CO	COM	532457108	87	314	SH		DFND		0	0	314
LINDE PLC	COM	G5494J103	4,513	13,107	SH		DFND		0	0	13,107
LKQ CORP	COM	501889208	67	1,136	SH		DFND		0	0	1,136
LOUISIANA PAC CORP	COM	546347105	146	1,877	SH		DFND		0	0	1,877
LOWES COS INC	COM	548661107	119	463	SH		DFND		0	0	463
LULULEMON ATHLETICA INC	COM	550021109	29	72	SH		DFND		0	0	72
LUMINAR TECHNOLOGIES INC	COM CL A	550424105	54	3,102	SH		DFND		0	0	3,102
LUXFER HOLDINGS PLC	SHS	G5698W116	47	2,452	SH		DFND		0	0	2,452
LYONDELLBASELL INDUSTRIES N	SHS - A -	N53745100	157	1,700	SH		DFND		0	0	1,700
MARAVAI LIFESCIENCES HLDGS I	COM CL A	56600D107	28	659	SH		DFND		0	0	659
MASCO CORP	COM	574599106	28	395	SH		DFND		0	0	395
MASIMO CORP	COM	574795100	80	268	SH		DFND		0	0	268
MCDONALDS CORP	COM	580135101	116	435	SH		DFND		0	0	435
MEDPACE HLDGS INC	COM	58506Q109	37	171	SH		DFND		0	0	171
MERCADOLIBRE INC	COM	58733R102	5,690	4,196	SH		DFND		0	0	4,196
MERCK & CO INC	COM	58933Y105	231	2,991	SH		DFND		0	0	2,991
MICRON TECHNOLOGY INC	COM	595112103	337	3,589	SH		DFND		0	0	3,589
MICROSOFT CORP	COM	594918104	24,245	71,505	SH		DFND		5,964	0	65,541
MICROVISION INC DEL	COM NEW	594960304	36	7,000	SH		DFND		0	0	7,000
MIRATI THERAPEUTICS INC	COM	60468T105	32	215	SH		DFND		0	0	215
MODERNA INC	COM	60770K107	242	960	SH		DFND		0	0	960
MONDELEZ INTL INC	CL A	609207105	39	586	SH		DFND		0	0	586
MOTOROLA SOLUTIONS INC	COM NEW	620076307	72	264	SH		DFND		0	0	264
MYRIAD GENETICS INC	COM	62855J104	81	2,927	SH		DFND		0	0	2,927
NANO DIMENSION LTD	SPONSORD ADS NEW	63008G203	42	10,802	SH		DFND		0	0	10,802
NATERA INC	COM	632307104	38	411	SH		DFND		0	0	411
NEOGENOMICS INC	COM NEW	64049M209	19	561	SH		DFND		0	0	561
NETEASE INC	SPONSORED ADR	64110W102	245	2,365	SH		DFND		0	0	2,365
NETFLIX INC	COM	64110L106	20,618	33,719	SH		DFND		2,135	0	31,584
NETSCOUT SYS INC	COM	64115T104	53	1,594	SH		DFND		0	0	1,594
NEXTERA ENERGY INC	COM	65339F101	1,451	15,544	SH		DFND		15,544	0	0
NIKE INC	CL B	654106103	173	1,033	SH		DFND		228	0	805
NIKOLA CORP	COM	654110105	190	18,608	SH		DFND		0	0	18,608
NOVAVAX INC	COM NEW	670002401	35	228	SH		DFND		0	0	228
NUCOR CORP	COM	670346105	152	1,338	SH		DFND		0	0	1,338
NVIDIA CORP	COM	67066G104	76,723	260,529	SH		DFND		203,316	0	57,213
NVIDIA CORP	PUT	67066G954	4,606	2,000	SH	Put	DFND		0	0	2,000
NXP SEMICONDUCTORS N V	NOTE 1.000%12/0	62952QAB6	12	53	SH		DFND		0	0	53
O REILLY AUTOMOTIVE INC NEW	COM	67103H107	4,421	6,300	SH		DFND		0	0	6,300
OLIN CORP	COM PAR $1	680665205	315	5,493	SH		DFND		0	0	5,493
ONECONNECT FINL TECHNOLOGY C	SPONSORD ADS	68248T105	50	19,889	SH		DFND		0	0	19,889
ONEOK INC NEW	COM	682680103	138	2,368	SH		DFND		0	0	2,368
OUSTER INC	COM	68989M103	41	7,687	SH		DFND		0	0	7,687
OWENS CORNING NEW	COM	690742101	12	134	SH		DFND		0	0	134
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	23	1,113	SH		DFND		0	0	1,113
PAYPAL HLDGS INC	COM	70450Y103	275	1,443	SH		DFND		703	0	740
PENTAIR PLC	SHS	G7S00T104	17	230	SH		DFND		0	0	230
PEPSICO INC	COM	713448108	79	457	SH		DFND		0	0	457
PERKINELMER INC	COM	714046109	128	640	SH		DFND		0	0	640
PETROLEO BRASILEIRO SA PETRO	PUT	71654V958	252	635	SH	Put	DFND		0	0	635
PETROLEO BRASILEIRO SA PETRO	SP ADR NON VTG	71654V101	31,673	3,149,459	SH		DFND		1,236,733	0	1,912,726
PETROLEO BRASILEIRO SA PETRO	SPONSORED ADR	71654V408	128,109	11,916,324	SH		DFND		1,627,211	0	10,289,113
PFIZER INC	COM	717081103	542	9,276	SH		DFND		0	0	9,276
PG&E CORP	COM	69331C108	18	1,527	SH		DFND		0	0	1,527
PLUG POWER INC	COM NEW	72919P202	189	6,547	SH		DFND		0	0	6,547
PROCAPS GROUP S A	SHS	L7756P102	2,861	297,974	SH		DFND		0	0	297,974
PROQR THRAPEUTICS N V	SHS EURO	N71542109	57	6,971	SH		DFND		0	0	6,971
QUALCOMM INC	COM	747525103	72	392	SH		DFND		0	0	392
QUEST DIAGNOSTICS INC	COM	74834L100	116	678	SH		DFND		0	0	678
QUIDEL CORP	COM	74838J101	29	221	SH		DFND		0	0	221
RAYONIER INC	COM	754907103	12	300	SH		DFND		0	0	300
RECURSION PHARMACEUTICALS IN	CL A	75629V104	44	2,530	SH		DFND		0	0	2,530
REGENERON PHARMACEUTICALS	COM	75886F107	75	117	SH		DFND		0	0	117
REPUBLIC SVCS INC	COM	760759100	58	422	SH		DFND		0	0	422
RIDGEBIO PHARMA INC COM	COM	10806X102	3	203	SH		DFND		0	0	203
ROBLOX CORP	CL A	771049103	246	2,444	SH		DFND		0	0	2,444
ROMEO POWER INC	COM	776153108	46	12,077	SH		DFND		0	0	12,077
ROSS STORES INC	COM	778296103	1,844	16,137	SH		DFND		0	0	16,137
ROYAL DUTCH SHELL PLC	SPONS ADR A	780259206	154	3,541	SH		DFND		0	0	3,541
S&P GLOBAL INC	COM	78409V104	104	220	SH		DFND		0	0	220
SALESFORCE COM INC	COM	79466L302	4,245	16,624	SH		DFND		0	0	16,624
SAREPTA THERAPEUTICS INC	COM	803607100	26	283	SH		DFND		0	0	283
SCHWAB CHARLES CORP NEW	COM	808513105	10,346	122,472	SH		DFND		0	0	122,472
SEA LTD	ADR	81141R100	612	2,732	SH		DFND		0	0	2,732
SEAGEN INC	COM	81181C104	81	513	SH		DFND		0	0	513
SELECT SECTOR SPDR TR	ENERGY	81369Y506	5,370	97,000	SH		DFND		0	0	97,000
SELECT SECTOR SPDR TR	PUT	81369Y953	1,906	10,000	SH	Put	DFND		0	0	10,000
SELECT SECTOR SPDR TR	PUT	81369Y956	294	3,000	SH	Put	DFND		0	0	3,000
SELECT SECTOR SPDR TR	PUT	81369Y957	44	2,500	SH	Put	DFND		0	0	2,500
SELECT SECTOR SPDR TR	PUT	81369Y954	1,184	8,000	SH	Put	DFND		0	0	8,000
SELECT SECTOR SPDR TR	PUT	81369Y950	2,112	19,000	SH	Put	DFND		0	0	19,000
SELECT SECTOR SPDR TR	PUT	81369Y955	597	7,500	SH	Put	DFND		0	0	7,500
SELECT SECTOR SPDR TR	SBI INT-FINL	81369Y605	3,195	81,804	SH		DFND		0	0	81,804
SELECT SECTOR SPDR TR	TECHNOLOGY	81369Y803	10,576	60,828	SH		DFND		0	0	60,828
SELECT SECTOR SPDR TR	SBI INT-UTILS	81369Y886	2,040	28,500	SH		DFND		0	0	28,500
SELECT SECTOR SPDR TR	SBI INT-INDS	81369Y704	12,796	120,930	SH		DFND		0	0	120,930
SELECT SECTOR SPDR TR	SBI CONS DISCR	81369Y407	334	1,633	SH		DFND		0	0	1,633
SELECT SECTOR SPDR TR	SBI CONS STPLS	81369Y308	183	2,370	SH		DFND		0	0	2,370
SELECT SECTOR SPDR TR	SBI MATERIALS	81369Y100	15,213	167,900	SH		DFND		0	0	167,900
SELECT SECTOR SPDR TR	RL EST SEL SEC	81369Y860	2,517	48,580	SH		DFND		0	0	48,580
SERVICENOW INC	COM	81762P102	87	133	SH		DFND		0	0	133
SILICON LABORATORIES INC	COM	826919102	51	245	SH		DFND		0	0	245
SL GREEN RLTY CORP	COM	78440X804	12	163	SH		DFND		0	0	163
SOCIEDAD QUIMICA MINERA DE C	SPON ADR SER B	833635105	23,994	476,431	SH		DFND		33,121	0	443,310
SONOS INC	COM	83570H108	2,699	90,000	SH		DFND		0	0	90,000
SONY CORP	SPONSORED ADR	835699307	605	4,788	SH		DFND		0	0	4,788
SOUTHERN COPPER CORP	COM	84265V105	31,024	502,740	SH		DFND		0	0	502,740
SPDR GOLD TR	GOLD SHS	78463V107	3,009	17,600	SH		DFND		0	0	17,600
SPDR INDEX SHS FDS	ASIA PACIF ETF	78463X301	2,500	20,500	SH		DFND		0	0	20,500
SPDR S&P 500 ETF TR	PUT	78462F953	1,238	4,695	SH	Put	DFND		0	0	4,695
SPDR S&P 500 ETF TR	TR UNIT	78462F103	347,142	730,959	SH		DFND		730,959	0	0
SPDR SER TR	S&P OILGAS EXP	78468R556	2,068	21,500	SH		DFND		0	0	21,500
SPDR SERIES TRUST	S&P METALS MNG	78464A755	291	6,500	SH		DFND		0	0	6,500
SQUARE INC	CL A	852234103	36	219	SH		DFND		0	0	219
STARBUCKS CORP	COM	855244109	5,585	48,046	SH		DFND		0	0	48,046
STEEL DYNAMICS INC	COM	858119100	25	400	SH		DFND		0	0	400
STELLANTIS N.V	COM	N82405106	188	10,016	SH		DFND		0	0	10,016
STEM INC	COM	85859N102	49	2,546	SH		DFND		0	0	2,546
STERICYCLE INC	COM	858912108	12	201	SH		DFND		0	0	201
SUNRUN INC	COM	86771W105	14	407	SH		DFND		0	0	407
SUZANO S A SPON	COM	86959K105	34,224	3,177,824	SH		DFND		428,006	0	2,749,818
SYNCHRONY FINL	COM	87165B103	131	2,835	SH		DFND		0	0	2,835
SYNNEX CORP	COM	87162W100	861	13,000	SH		DFND		13,000	0	0
SYNOPSYS INC	COM	871607107	69	187	SH		DFND		0	0	187
T MOBILE US INC	COM	872590104	2,329	19,989	SH		DFND		0	0	19,989
TAIWAN SEMICONDUCTOR MFG LTD	SPONSORED ADR	874039100	73,687	123,169	SH		DFND		0	0	123,169
TAKE-TWO INTERACTIVE SOFTWAR	COM	874054109	248	1,372	SH		DFND		0	0	1,372
TARGET CORP	COM	87612E106	2,716	11,710	SH		DFND		0	0	11,710
TECHNIPFMC PLC	COM	G87110105	126	21,528	SH		DFND		0	0	21,528
TELADOC HEALTH INC	COM	87918A105	76	808	SH		DFND		0	0	808
TESLA INC	COM	88160R101	17,936	16,757	SH		DFND		0	0	16,757
TEXTRON INC	COM	883203101	68	882	SH		DFND		0	0	882
THE TRADE DESK INC	COM CL A	88339J105	27	288	SH		DFND		0	0	288
THERMO FISHER SCIENTIFIC INC	COM	883556102	361	542	SH		DFND		0	0	542
TIM S A	COM	88706T108	9,369	807,953	SH		DFND		158,231	0	649,722
TOPBUILD CORP	COM	89055F103	18	65	SH		DFND		0	0	65
TRACTOR SUPPLY CO	COM	892356106	68	289	SH		DFND		0	0	289
TREX CO INC	COM	89531P105	33	249	SH		DFND		0	0	249
TUSIMPLE HLDGS INC	CL A	90089L108	44	1,259	SH		DFND		0	0	1,259
TWILIO INC	CL A	90138F102	29	111	SH		DFND		0	0	111
TWIST BIOSCIENCE CORP	COM	90184D100	20	252	SH		DFND		0	0	252
TWITTER INC	COM	90184L102	20	448	SH		DFND		0	0	448
TYSON FOODS INC	CL A	902494103	233	2,694	SH		DFND		0	0	2,694
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	11	133	SH		DFND		0	0	133
UNITED MICROELECTRONICS CORP	SPON ADR NEW	910873405	7,410	114,000	SH		DFND		114,000	0	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	85	396	SH		DFND		0	0	396
UNITEDHEALTH GROUP INC	COM	91324P102	221	438	SH		DFND		0	0	438
UNIVERSAL DISPLAY CORP	COM	91347P105	38	229	SH		DFND		0	0	229
VALE S A	SPONSORED ADS	91912E105	101,031	7,326,007	SH		DFND		1,342,505	0	5,983,502
VANECK VECTORS ETF TR	PUT	92189F953	286	2,000	SH	Put	DFND		0	0	2,000
VANECK VECTORS ETF TR	RUSSIA ETF	92189F403	3,090	116,050	SH		DFND		0	0	116,050
VANGUARD INDEX FDS	PUT	922908953	411	3,000	SH	Put	DFND		0	0	3,000
VANGUARD INDEX FDS	S&P 500 ETF SHS	922908363	502,670	1,148,252	SH		DFND		0	0	1,148,252
VANGUARD INDEX FDS	REAL ESTATE ETF	922908553	2,593	22,350	SH		DFND		0	0	22,350
VANGUARD INTL EQUITY INDEX F	FTSE EUROPE ETF	922042874	86,772	1,271,570	SH		DFND		1,271,570	0	0
VANGUARD INTL EQUITY INDEX F	TT WRLD ST ETF	922042742	15,974	148,288	SH		DFND		0	0	148,288
VARONIS SYS INC	COM	922280102	48	952	SH		DFND		0	0	952
VELODYNE LIDAR INC	COM	92259F101	44	9,113	SH		DFND		0	0	9,113
VERACYTE INC	COM	92337F107	17	402	SH		DFND		0	0	402
VERTEX PHARMACEUTICALS INC	COM	92532F100	203	914	SH		DFND		0	0	914
VIEW INC	COM CL A	92671V106	43	10,596	SH		DFND		0	0	10,596
VIRGIN GALACTIC HOLDINGS INC	COM	92766K106	43	3,086	SH		DFND		0	0	3,086
VISA INC	COM CL A	92826C839	243	1,116	SH		DFND		0	0	1,116
VMWARE INC	CL A COM	928563402	104	886	SH		DFND		0	0	886
VORNADO RLTY TR	SH BEN INT	929042109	14	324	SH		DFND		0	0	324
VUZIX CORP	COM NEW	92921W300	42	4,824	SH		DFND		0	0	4,824
WABTEC CORP	COM	929740108	41	443	SH		DFND		0	0	443
WALMART INC	COM	931142103	5,221	36,469	SH		DFND		0	0	36,469
WASTE MGMT INC DEL	COM	94106L109	141	850	SH		DFND		0	0	850
WATERS CORP	COM	941848103	83	222	SH		DFND		0	0	222
WELLS FARGO CO NEW	COM	949746101	6,824	141,868	SH		DFND		0	0	141,868
WESTERN DIGITAL CORP	COM	958102105	77	1,176	SH		DFND		0	0	1,176
WESTLAKE CHEM CORP	COM	960413102	159	1,637	SH		DFND		0	0	1,637
WESTPORT FUEL SYSTEMS INC	COM NEW	960908309	138	58,707	SH		DFND		0	0	58,707
WESTROCK CO	COM	96145D105	25	557	SH		DFND		0	0	557
WEYERHAEUSER CO	COM	962166104	72	1,768	SH		DFND		0	0	1,768
WISDOMTREE TR	INDIA ERNGS FD	97717W422	1,278	35,000	SH		DFND		0	0	35,000
WOLFSPEED INC	COM	977852102	64	582	SH		DFND		0	0	582
WORKHORSE GROUP INC	COM NEW	98138J206	41	9,096	SH		DFND		0	0	9,096
WORTHINGTON INDS INC	COM	981811102	153	2,829	SH		DFND		0	0	2,829
XP INC	CL A	G98239109	31,517	1,109,119	SH		DFND		46,985	0	1,062,134
XPERI HOLDING CORP	COM	98390M103	48	2,506	SH		DFND		0	0	2,506
XYLEM INC	COM	98419M100	35	294	SH		DFND		0	0	294
YELP INC	CL A	985817105	49	1,345	SH		DFND		0	0	1,345
YPF SOCIEDAD ANONIMA	SPON ADR CL D	984245100	2,657	695,453	SH		DFND		0	0	695,453
ZIMMER BIOMET HLDGS INC	COM	98956P102	76	595	SH		DFND		0	0	595
ZOETIS INC	CL A	98978V103	154	629	SH		DFND		0	0	629
ZOOM VIDEO COMMUNICATIONS IN	CL A	98980L101	708	3,844	SH		DFND		3,746	0	98
ZTO EXPRESS CAYMAN INC	SPONSORED ADR	98980A105	322	11,400	SH		DFND		0	0	11,400