Itaú Unibanco Holding (ITUB) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ARM HOLDINGS PLC	SPONSORED ADR	042068205	16,656,050	215,000	SH		DFND		0	0	215,000
IMMUNOVANT INC	COM	45258J102	2,738	65	SH		DFND		0	0	65
10X GENOMICS INC	CL A COM	88025U109	18,579	332	SH		DFND		0	0	332
4D MOLECULAR THERAPEUTICS IN	COM	35104E100	33,348	1,646	SH		DFND		0	0	1,646
ABBOTT LABS	COM	002824100	60,098	546	SH		DFND		0	0	546
ABBVIE INC	COM	00287Y109	1,200,088	7,744	SH		DFND		7,315	0	429
ACUITY BRANDS INC	COM	00508Y102	5,735	28	SH		DFND		0	0	28
ADVANCED DRAIN SYS INC DEL	COM	00790R104	6,469	46	SH		DFND		0	0	46
ADVANCED MICRO DEVICES INC	COM	007903107	16,819,481	114,100	SH		DFND		0	0	114,100
AGILENT TECHNOLOGIES INC	COM	00846U101	134,998	971	SH		DFND		0	0	971
AIR PRODS & CHEMS INC	COM	009158106	96,378	352	SH		DFND		0	0	352
ALCOA CORP	COM	013872106	9,052,100	262,000	SH		DFND		0	0	262,000
ALIBABA GROUP HLDG LTD	SPONSORED ADS	01609W102	1,419,053	18,372	SH		DFND		0	0	18,372
ALLOGENE THERAPEUTICS INC	COM	019770106	29,410	9,162	SH		DFND		0	0	9,162
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	132,647	693	SH		DFND		0	0	693
ALPHABET INC	CAP STK CL A	02079K305	11,119,184	79,599	SH		DFND		4,894	0	74,705
ALPHABET INC	CAP STK CL C	02079K107	2,701,294	19,121	SH		DFND		0	0	19,121
AMAZON COM INC	COM	023135106	44,118,362	290,367	SH		DFND		20,068	0	270,299
AMBARELLA INC	SHS	G037AX101	25,190	411	SH		DFND		0	0	411
AMBEV SA	SPONSORED ADR	02319V103	5,979,642	2,143,241	SH		DFND		0	0	2,143,241
AMBEV SA	SPONSORED ADR	02319V103	388,647	139,300	SH		DFND	1	0	0	139,300
AMERICA MOVIL SAB DE CV	SPONSORED ADR	02390A101	800,241	43,291	SH		DFND		0	0	43,291
AMERICA MOVIL SAB DE CV	SPONSORED ADR	02390A101	20,855,296	1,128,218	SH		DFND	1	199,615	0	928,603
AMERICAN HOMES 4 RENT	CL A	02665T306	381,150	10,500	SH		DFND		0	0	10,500
AMERICAN WTR WKS CO INC NEW	COM	030420103	26,794	203	SH		DFND		0	0	203
AMGEN INC	COM	031162100	67,109	233	SH		DFND		0	0	233
ANTHEM INC	COM	036752103	35,367	75	SH		DFND		0	0	75
APARTMENT INVT & MGMT CO	CL A	03748R747	535,458	67,100	SH		DFND		0	0	67,100
APPLIED MATLS INC	COM	038222105	33,548	207	SH		DFND		0	0	207
ARCOS DORADOS HOLDINGS INC	SHS CLASS -A -	G0457F107	6,922,002	545,469	SH		DFND		0	0	545,469
ARMSTRONG WORLD INDS INC NEW	COM	04247X102	5,801	59	SH		DFND		0	0	59
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	4,376	143	SH		DFND		0	0	143
ASANA INC	CL A	04342Y104	23,021	1,211	SH		DFND		0	0	1,211
ASHLAND GLOBAL HLDGS INC	COM	044186104	7,672	91	SH		DFND		0	0	91
ASML HOLDING N V	N Y REGISTRY SHS	N07059210	8,639,490	11,400	SH		DFND		0	0	11,400
ASTRAZENECA PLC	SPONSORED ADR	046353108	1,102,452	16,369	SH		DFND		0	0	16,369
AT&T INC	PUT	00206R952	5	500	SH	Call	DFND		0	0	500
AURORA INNOVATION INC	COM	051774107	41,498	9,496	SH		DFND		0	0	9,496
AVALONBAY CMNTYS INC	COM	053484101	805,800	4,250	SH		DFND		0	0	4,250
AVIDITY BIOSCIENCES INC	COM	05370A108	26,770	2,958	SH		DFND		0	0	2,958
AVIS BUDGET GROUP	COM	053774105	7,445	42	SH		DFND		0	0	42
BALL CORP	COM	058498106	12,367	215	SH		DFND		0	0	215
BALLARD PWR SYS INC NEW	COM	058586108	110,408	29,840	SH		DFND		0	0	29,840
BANCO BRADESCO S A	SP ADR PFD NEW	059460303	53,612,306	15,102,058	SH		DFND		0	0	15,102,058
BANCO BRADESCO S A	SP ADR PFD NEW	059460303	78,079,588	21,994,250	SH		DFND	1	1,821,213	0	20,173,037
BANCO DE CHILE	SPONSORED ADS	059520106	72,725	3,151	SH		DFND		0	0	3,151
BANCO DE CHILE	SPONSORED ADS	059520106	2,035,518	88,194	SH		DFND	1	20,650	0	67,544
BANCO MACRO SA	SPON ADR B	05961W105	83,230	2,900	SH		DFND		0	0	2,900
BANCO MACRO SA	SPON ADR B	05961W105	83,230	2,900	SH		DFND	1	2,900	0	0
BANCO SANTANDER BRASIL S A	ADS REP 1 UNIT	05967A107	950	145	SH		DFND		0	0	145
BANCO SANTANDER CHILE NEW	SP ADR REP COM	05965X109	12,435	638	SH		DFND		0	0	638
BANCO SANTANDER CHILE NEW	SP ADR REP COM	05965X109	321,994	16,521	SH		DFND	1	3,845	0	12,676
BARRICK GOLD CORP	COM	067901108	202,789	11,210	SH		DFND		0	0	11,210
BARRICK GOLD CORP	COM	067901108	202,789	11,210	SH		DFND	1	11,210	0	0
BEAM THERAPEUTICS INC	COM	07373V105	6,424	236	SH		DFND		0	0	236
BERKSHIRE HATHAWAY INC DEL	CL B NEW	084670702	715	2	SH		DFND		0	0	2
BEST BUY INC	COM	086516101	5,625,357	71,862	SH		DFND		71,862	0	0
BIGCOMMERCE HLDGS INC	COM SER 1	08975P108	24,812	2,550	SH		DFND		0	0	2,550
BILIBILI INC	SPONS ADS REP Z	090040106	24,377	2,003	SH		DFND		0	0	2,003
BIO RAD LABS INC	CL A	090572207	12,270	38	SH		DFND		0	0	38
BIO TECHNE CORP	COM	09073M104	46,065	597	SH		DFND		0	0	597
BIOGEN INC	COM	09062X103	69,350	268	SH		DFND		0	0	268
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	64,312	667	SH		DFND		0	0	667
BLOOM ENERGY CORP	COM CL A	093712107	134,917	9,116	SH		DFND		0	0	9,116
BLUEBIRD BIO INC	COM	09609G100	6,718	4,868	SH		DFND		0	0	4,868
BLUEPRINT MEDICINES CORP	COM	09627Y109	7,287	79	SH		DFND		0	0	79
BOOKING HOLDINGS INC	COM	09857L108	39,019	11	SH		DFND		0	0	11
BOSTON PROPERTIES INC	COM	101121101	13,192	188	SH		DFND		0	0	188
BRISTOL MYERS SQUIBB CO	COM	110122108	122,528	2,388	SH		DFND		0	0	2,388
BROADCOM INC	COM	11135F101	9,412,220	8,432	SH		DFND		0	0	8,432
BROOKS AUTOMATION INC	COM	114340102	3,518	54	SH		DFND		0	0	54
BRUKER CORP	COM	116794108	13,888	189	SH		DFND		0	0	189
BUTTERFLY NETWORK INC	COM CL A	124155102	16,203	15,003	SH		DFND		0	0	15,003
C3 AI INC	CL A	12468P104	23,140	806	SH		DFND		0	0	806
CAPRI HOLDINGS LIMITED	SHS	G1890L107	2,824,640	56,000	SH		DFND		0	0	56,000
CARLISLE COS INC	COM	142339100	6,249	20	SH		DFND		0	0	20
CATALENT INC	COM	148806102	23,319	519	SH		DFND		0	0	519
CEMEX SAB DE CV	SPON ADR NEW	151290889	35,207,949	4,714,463	SH		DFND		0	0	4,714,463
CEMEX SAB DE CV	SPON ADR NEW	151290889	61,296,113	8,207,756	SH		DFND	1	837,224	0	7,370,532
CENTRAIS ELETRICAS BRASILEIR	SPONSORED ADR	15234Q207	10,549,587	1,223,850	SH		DFND		0	0	1,223,850
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	3,901	92	SH		DFND		0	0	92
CHARLES RIV LABS INTL INC	COM	159864107	13,711	58	SH		DFND		0	0	58
CHART INDS INC	COM PAR $0.01	16115Q308	105,383	773	SH		DFND		0	0	773
CHEMOURS CO	COM	163851108	92,412	2,930	SH		DFND		0	0	2,930
CI&T INC	COM CL A	G21307106	2,179,486	414,351	SH		DFND		0	0	414,351
CISCO SYS INC	COM	17275R102	1,427,847	28,263	SH		DFND		28,263	0	0
CLEAN HARBORS INC	COM	184496107	9,075	52	SH		DFND		0	0	52
CLEARWAY ENERGY INC	CL A	18539C105	5,397	211	SH		DFND		0	0	211
CLEARWAY ENERGY INC	CL C	18539C204	5,486	200	SH		DFND		0	0	200
COCA COLA CO	COM	191216100	5,357,562	90,914	SH		DFND		17,580	0	73,334
COCA COLA FEMSA S A B DE C V	SPON ADR REP L	191241108	16,807,877	185,567	SH		DFND		0	0	185,567
COCA COLA FEMSA S A B DE C V	SPON ADR REP L	191241108	27,889,824	307,917	SH		DFND	1	28,017	0	279,900
COINBASE GLOBAL INC	COM CL A	19260Q107	179,833	1,034	SH		DFND		860	0	174
COLGATE PALMOLIVE CO	COM	194162103	27,181	341	SH		DFND		0	0	341
COMCAST CORP NEW	CL A	20030N101	51,524	1,175	SH		DFND		0	0	1,175
COMPANHIA DE SANEAMENTO BASI	SPONSORED ADR	20441A102	1,310,404	86,041	SH		DFND		0	0	86,041
COMPANHIA SIDERURGICA NACION	SPONSORED ADR	20440W105	891,022	222,200	SH		DFND		0	0	222,200
COPA HOLDINGS SA	CL A	P31076105	1,882,655	17,567	SH		DFND		0	0	17,567
CORVEL CORP	COM	221006109	2,472	10	SH		DFND		0	0	10
COSAN LTD	SHS A	22113B103	10,051,246	641,842	SH		DFND		641,842	0	0
COSTAR GROUP INC	COM	22160N109	5,156	59	SH		DFND		0	0	59
COUCHBASE INC	COM	22207T101	26,506	1,177	SH		DFND		0	0	1,177
CREDICORP LTD	COM	G2519Y108	40,302,395	280,725	SH		DFND		0	0	280,725
CREDICORP LTD	COM	G2519Y108	71,534,185	498,269	SH		DFND	1	49,765	0	448,504
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	93,775	1,498	SH		DFND		0	0	1,498
CROWDSTRIKE HLDGS INC	CL A	22788C105	5,634,860	22,000	SH		DFND		0	0	22,000
CSX CORP	COM	126408103	33,110	955	SH		DFND		0	0	955
CUMMINS INC	COM	231021106	100,619	420	SH		DFND		0	0	420
DARLING INGREDIENTS INC	COM	237266101	13,307	267	SH		DFND		0	0	267
DBX ETF TR	XTRACK HRVST CSI	233051879	357,000	15,000	SH		DFND		0	0	15,000
DEERE & CO	COM	244199105	2,359,233	5,900	SH		DFND		0	0	5,900
DELTA AIR LINES INC DEL	COM NEW	247361702	3,656,700	90,000	SH		DFND		0	0	90,000
DISNEY WALT CO	COM DISNEY	254687106	695,323	7,701	SH		DFND		2,027	0	5,674
DOLLAR GEN CORP NEW	COM	256677105	4,464,054	32,836	SH		DFND		0	0	32,836
EATON CORP PLC	SHS	G29183103	45,033	187	SH		DFND		0	0	187
EDITAS MEDICINE INC	COM	28106W103	21,435	2,116	SH		DFND		0	0	2,116
EDWARDS LIFESCIENCES CORP	COM	28176E108	68,930	904	SH		DFND		0	0	904
EHANG HLDGS LTD	ADS	26853E102	23,150	1,378	SH		DFND		0	0	1,378
ELECTRONIC ARTS INC	COM	285512109	5,062	37	SH		DFND		0	0	37
EMBRAER S A	SP ADR REP 4 COM	29082A107	17,174,842	977,460	SH		DFND		0	0	977,460
EMBRAER S A	SP ADR REP 4 COM	29082A107	25,889,424	1,473,427	SH		DFND	1	128,236	0	1,345,191
ENPHASE ENERGY INC	COM	29355A107	65,277	494	SH		DFND		250	0	244
EOS ENERGY ENTERPRISES INC	COM CL A	29415C101	23,243	21,324	SH		DFND		0	0	21,324
EQUINIX INC	COM PAR $0.001	29444U700	82,150	102	SH		DFND		0	0	102
EQUITY RESIDENTIAL	SH BEN INT	29476L107	825,000	13,200	SH		DFND		0	0	13,200
ESSENTIAL UTILS INC	COM	29670G102	5,229	140	SH		DFND		0	0	140
ESSEX PPTY TR INC	COM	297178105	581,325	2,300	SH		DFND		0	0	2,300
ETF MANAGERS TR	PRIME MOBILE PAY	26924G409	515,900	11,000	SH		DFND		0	0	11,000
EXACT SCIENCES CORP	COM	30063P105	93,363	1,262	SH		DFND		0	0	1,262
EXELIXIS INC	COM	30161Q104	11,443	477	SH		DFND		0	0	477
FACEBOOK INC	CL A	30303M102	23,205,618	65,560	SH		DFND		951	0	64,609
FASTLY INC	CL A	31188V100	24,689	1,387	SH		DFND		0	0	1,387
FEDEX CORP	COM	31428X106	8,854	35	SH		DFND		0	0	35
FIRST SOLAR INC	COM	336433107	33,595	195	SH		DFND		0	0	195
FISERV INC	COM	337738108	24,044	181	SH		DFND		0	0	181
FISKER INC	CL A COM STK	33813J106	29,111	16,635	SH		DFND		0	0	16,635
FOMENTO ECONOMICO MEXICANO S	SPON ADR UNITS	344419106	87,812,347	704,843	SH		DFND		0	0	704,843
FOMENTO ECONOMICO MEXICANO S	SPON ADR UNITS	344419106	161,731,430	1,298,169	SH		DFND	1	137,705	0	1,160,464
FORTUNE BRANDS HOME & SEC IN	COM	34964C106	5,558	73	SH		DFND		0	0	73
FRANKLIN TEMPLETON ETF TR	FTSE CANADA	35473P827	1,724,026	51,866	SH		DFND		0	0	51,866
FRANKLIN TEMPLETON ETF TR	FTSE JAPAN ETF	35473P744	5,226,041	186,711	SH		DFND		0	0	186,711
FUELCELL ENERGY INC	COM	35952H601	128,322	80,201	SH		DFND		0	0	80,201
GENERAL ELECTRIC CO	COM	369604301	1,801,453	14,041	SH		DFND		0	0	14,041
GERDAU SA	SPON ADR REP PFD	373737105	8,835,895	1,821,834	SH		DFND		0	0	1,821,834
GERDAU SA	SPON ADR REP PFD	373737105	5,417,178	1,116,944	SH		DFND	1	245,669	0	871,275
GILEAD SCIENCES INC	COM	375558103	179,275	2,213	SH		DFND		695	0	1,518
GINKGO BIOWORKS HOLDINGS INC	CL A SHS	37611X100	30,493	18,043	SH		DFND		0	0	18,043
GLOBAL X FDS	GLOBAL X URANIUM	37954Y871	17,110,288	617,923	SH		DFND		0	0	617,923
GLOBAL X FDS	LITHIUM BTRY ETF	37954Y855	46,457	912	SH		DFND		0	0	912
GLOBANT S A	COM	L44385109	190,384	800	SH		DFND		0	0	800
GLOBANT S A	COM	L44385109	190,384	800	SH		DFND	1	800	0	0
GRAPHIC PACKAGING HLDG CO	COM	388689101	496,000	20,000	SH		DFND		0	0	20,000
GRUPO AEROPORTUARIO DEL SURE	SPON ADR SER B	40051E202	20,310,786	71,709	SH		DFND		0	0	71,709
GRUPO AEROPORTUARIO DEL SURE	SPON ADR SER B	40051E202	37,368,289	131,932	SH		DFND	1	13,901	0	118,031
GRUPO AEROPUERTO DEL PACIFIC	SPON ADR B	400506101	4,630,959	26,966	SH		DFND		0	0	26,966
GRUPO AEROPUERTO DEL PACIFIC	SPON ADR B	400506101	17,466,645	101,708	SH		DFND	1	18,230	0	83,478
GRUPO FINANCIERO GALICIA S A	SP ADR 10 SH B	399909100	1,736,000	100,000	SH		DFND		0	0	100,000
GRUPO TELEVISA SA	SPON ADR REP ORD	40049J206	41,530	13,182	SH		DFND		0	0	13,182
GRUPO TELEVISA SA	SPON ADR REP ORD	40049J206	41,530	13,182	SH		DFND	1	0	0	13,182
GUARDANT HEALTH INC	COM	40131M109	77,390	2,861	SH		DFND		0	0	2,861
HDFC BANK LTD	ADR REPS 3 SHS	40415F101	153,682	2,290	SH		DFND		0	0	2,290
HDFC BANK LTD	ADR REPS 3 SHS	40415F101	153,682	2,290	SH		DFND	1	2,290	0	0
HEWLETT PACKARD ENTERPRISE C	COM	42824C109	46,287	2,726	SH		DFND		0	0	2,726
HEXCEL CORP NEW	COM	428291108	7,744	105	SH		DFND		0	0	105
HOLOGIC INC	COM	436440101	35,082	491	SH		DFND		0	0	491
HYSTER YALE MATLS HANDLING I	CL A	449172105	49,441	795	SH		DFND		0	0	795
ICICI BK LTD	ADR	45104G104	458,920	19,250	SH		DFND		0	0	19,250
ICICI BK LTD	ADR	45104G104	458,920	19,250	SH		DFND	1	19,250	0	0
ILLUMINA INC	COM	452327109	510,856	3,617	SH		DFND		0	0	3,617
IMMUNOGEN INC	COM	45253H101	26,448	892	SH		DFND		0	0	892
INCYTE CORP	COM	45337C102	71,141	1,133	SH		DFND		0	0	1,133
INDIE SEMICONDUCTOR INC	CLASS A COM	45569U101	25,879	3,191	SH		DFND		0	0	3,191
INFOSYS LTD	SPONSORED ADR	456788108	255,261	13,888	SH		DFND		0	0	13,888
INNOVIZ TECHNOLOGIES LTD	SHS	M5R635108	33,153	13,104	SH		DFND		0	0	13,104
INTEGRA LIFESCIENCES HLDGS C	COM NEW	457985208	4,181	96	SH		DFND		0	0	96
INTELLIA THERAPEUTICS INC	COM	45826J105	97,781	3,207	SH		DFND		0	0	3,207
INTUITIVE SURGICAL INC	COM NEW	46120E602	68,147	202	SH		DFND		0	0	202
INVESCO ACTIVELY MANAGD ETF	ACTIVE US REAL	46090A101	2,129,504	5,200	SH		DFND		0	0	5,200
INVESCO DB MLTI SECTR CMMTY	AGRICULTURE FD	46140H106	1,663,348	80,200	SH		DFND		80,200	0	0
INVITATION HOMES INC	COM	46187W107	393,845	11,350	SH		DFND		0	0	11,350
IONIS PHARMACEUTICALS INC	COM	462222100	72,293	1,429	SH		DFND		0	0	1,429
IQVIA HLDGS INC	COM	46266C105	58,308	252	SH		DFND		0	0	252
ISHARES INC	MSCI BRAZIL ETF	464286400	15,490,776	443,100	SH		DFND		0	0	443,100
ISHARES INC	MSCI JPN ETF NEW	46434G822	314,350	4,901	SH		DFND		0	0	4,901
ISHARES INC	MSCI JPN ETF NEW	46434G822	43,148,453	672,723	SH		DFND	1	672,723	0	0
ISHARES INC	MSCI TAIWAN ETF	46434G772	322,210	7,000	SH		DFND		0	0	7,000
ISHARES INC	MSCI PAC JP ETF	464286665	295,188	6,800	SH		DFND		0	0	6,800
ISHARES INC	MSCI STH KOR ETF	464286772	659,800	10,000	SH		DFND		0	0	10,000
ISHARES INC	CORE MSCI EMKT	46434G103	546,264	10,800	SH		DFND		0	0	10,800
ISHARES SILVER TRUST	ISHARES	46428Q109	55,016	2,526	SH		DFND		0	0	2,526
ISHARES TR	CALL	464287904	196,418	2,000	SH	Call	DFND		0	0	2,000
ISHARES TR	MSCI EMG MKT ETF	464287234	11,666,449	290,138	SH		DFND	1	290,138	0	0
ISHARES TR	RUSSELL 2000 ETF	464287655	16,715,530	83,282	SH		DFND		0	0	83,282
ISHARES TR	IBOXX INV CP ETF	464287242	8,299	75	SH		DFND	1	75	0	0
ISHARES TR	S&P 500 VAL ETF	464287408	4,695,030	27,000	SH		DFND		0	0	27,000
ISHARES TR	10-20 YR TRS ETF	464288653	115,248,941	1,064,557	SH		DFND	1	1,064,557	0	0
ISHARES TR	US TREAS BD ETF	46429B267	102,846,966	4,463,844	SH		DFND	1	4,463,844	0	0
ISHARES TR	NASDAQ BIOTECH	464287556	29,220,656	215,095	SH		DFND		0	0	215,095
ISHARES TR	NA TEC SFTWR ETF	464287515	1,633,360	4,000	SH		DFND		0	0	4,000
ISHARES TR	BARCLAYS 7 10 YR	464287440	2,409,636	13,688	SH		DFND	1	13,688	0	0
ISHARES TR	U.S. REAL ES ETF	464287739	1,413,656	15,465	SH		DFND		0	0	15,465
ISHARES TR	CORE S&P500 ETF	464287200	2,711,302	5,401	SH		DFND	1	5,401	0	0
ITAU UNIBANCO HLDG S A	SPON ADR REP PFD	465562106	58,918,375	8,826,300	SH		DFND		0	0	8,826,300
ITAU UNIBANCO HLDG S A	SPON ADR REP PFD	465562106	145,752,449	21,834,527	SH		DFND	1	2,282,495	0	19,552,032
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	63,468	516	SH		DFND		0	0	516
JOHNSON & JOHNSON	COM	478160104	502,822	3,208	SH		DFND		2,807	0	401
JOHNSON CTLS INTL PLC	SHS	G51502105	16,024	278	SH		DFND		0	0	278
JPMORGAN CHASE & CO	COM	46625H100	6,024,772	35,419	SH		DFND		0	0	35,419
JUMIA TECHNOLOGIES AG	SPONSORED ADS	48138M105	17,445	4,942	SH		DFND		0	0	4,942
KEURIG DR PEPPER INC	COM	49271V100	6,612,920	198,467	SH		DFND		0	0	198,467
KRAFT HEINZ CO	COM	500754106	4,696	127	SH		DFND		0	0	127
KRANESHARES TR	CALL	500767906	16,700	3,000	SH	Call	DFND		0	0	3,000
KROGER CO	COM	501044101	10,833	237	SH		DFND		0	0	237
LAM RESEARCH CORP	COM	512807108	4,594,968	5,819	SH		DFND		0	0	5,819
LANZATECH GLOBAL INC	COM	51655R101	18,183	3,615	SH		DFND		0	0	3,615
LI AUTO INC	SPONSORED ADS	50202M102	1,657,350	45,000	SH		DFND		0	0	45,000
LILLY ELI & CO	COM	532457108	62,372	107	SH		DFND		0	0	107
LINDE PLC	COM	G5494J103	95,695	233	SH		DFND		0	0	233
LISTED FD TR	ROUNDHILL BALL	53656F417	393,642	34,200	SH		DFND		0	0	34,200
LOCKHEED MARTIN CORP	COM	539830109	446,718	990	SH		DFND		0	0	990
LOUISIANA PAC CORP	COM	546347105	5,808	82	SH		DFND		0	0	82
LOWES COS INC	COM	548661107	4,340,615	19,504	SH		DFND		0	0	19,504
LUCID GROUP INC	COM	549498103	29,752	7,067	SH		DFND		0	0	7,067
LUMINAR TECHNOLOGIES INC	COM CL A	550424105	30,519	9,056	SH		DFND		0	0	9,056
LUXFER HOLDINGS PLC	SHS	G5698W116	34,365	3,844	SH		DFND		0	0	3,844
LVMH MOET HENNESSY LOUIS VUITTON AS	COM	502441306	6,964,280	43,000	SH		DFND		0	0	43,000
MAKEMYTRIP LIMITED MAURITIUS	SHS	V5633W109	134,363	2,860	SH		DFND		0	0	2,860
MAKEMYTRIP LIMITED MAURITIUS	SHS	V5633W109	134,363	2,860	SH		DFND	1	2,860	0	0
MASCO CORP	COM	574599106	7,100	106	SH		DFND		0	0	106
MASTERCARD INCORPORATED	CL A	57636Q104	405,004	950	SH		DFND		0	0	950
MATTERPORT INC	CALL	577096900	132,721	6,000	SH	Call	DFND		0	0	6,000
MATTERPORT INC	COM CL A	577096100	4,195,744	1,559,756	SH		DFND		1,559,756	0	0
MCDONALDS CORP	COM	580135101	64,936	219	SH		DFND		0	0	219
MEDPACE HLDGS INC	COM	58506Q109	28,201	92	SH		DFND		0	0	92
MERCADOLIBRE INC	COM	58733R102	59,343,798	37,632	SH		DFND		0	0	37,632
MERCADOLIBRE INC	COM	58733R102	19,373,588	12,832	SH		DFND	1	1,278	0	11,554
MERCK & CO INC	COM	58933Y105	64,758	594	SH		DFND		0	0	594
METTLER TOLEDO INTERNATIONAL	COM	592688105	69,139	57	SH		DFND		0	0	57
MICRON TECHNOLOGY INC	COM	595112103	13,950,188	163,466	SH		DFND		0	0	163,466
MICROSOFT CORP	COM	594918104	57,755,984	153,590	SH		DFND		9,061	0	144,529
MICROVISION INC DEL	COM NEW	594960304	22,477	8,450	SH		DFND		0	0	8,450
MID AMER APT CMNTYS INC	COM	59522J103	819,300	6,000	SH		DFND		0	0	6,000
MIRATI THERAPEUTICS INC	COM	60468T105	7,931	135	SH		DFND		0	0	135
MODERNA INC	COM	60770K107	146,987	1,478	SH		DFND		0	0	1,478
MONDELEZ INTL INC	CL A	609207105	44,182	610	SH		DFND		0	0	610
NANO DIMENSION LTD	SPONSORD ADS NEW	63008G203	23,820	9,925	SH		DFND		0	0	9,925
NATERA INC	COM	632307104	26,559	424	SH		DFND		0	0	424
NATURA &CO HLDG S A	ADS	63884N108	1,500,012	219,300	SH		DFND		0	0	219,300
NEOGENOMICS INC	COM NEW	64049M209	6,828	422	SH		DFND		0	0	422
NETFLIX INC	COM	64110L106	11,021,503	22,637	SH		DFND		3,281	0	19,356
NEW ORIENTAL ED & TECH GRP I	SPON ADR	647581206	131,171	1,790	SH		DFND		0	0	1,790
NEW ORIENTAL ED & TECH GRP I	SPON ADR	647581206	131,171	1,790	SH		DFND	1	1,790	0	0
NEWMONT MINING CORP	COM	651639106	661,247	15,976	SH		DFND		15,976	0	0
NEXTERA ENERGY INC	COM	65339F101	7,425,526	122,251	SH		DFND		122,251	0	0
NIKE INC	CL B	654106103	91,090	839	SH		DFND		228	0	611
NIKOLA CORP	COM	654110105	99,352	113,571	SH		DFND		0	0	113,571
NIO INC	SPON ADS	62914V106	1,697,400	180,000	SH		DFND		0	0	180,000
NORFOLK SOUTHERN CORP	COM	655844108	24,111	102	SH		DFND		0	0	102
NORTHROP GRUMMAN CORP	COM	666807102	419,112	900	SH		DFND		0	0	900
NU HLDGS LTD	ORD SHS CL A	G6683N103	22,641,290	2,718,042	SH		DFND		0	0	2,718,042
NU HLDGS LTD	ORD SHS CL A	G6683N103	12,280,086	1,474,200	SH		DFND	1	120,300	0	1,353,900
NUTANIX INC	CL A	67059N108	22,605	474	SH		DFND		0	0	474
NVIDIA CORP	COM	67066G104	37,968,517	76,670	SH		DFND		1,048	0	75,622
NXP SEMICONDUCTORS N V	COM	N6596X109	9,255,203	40,054	SH		DFND		0	0	40,054
OCCIDENTAL PETE CORP DEL	COM	674599105	161,259	2,689	SH		DFND		0	0	2,689
OLIN CORP	COM PAR $1	680665205	114,536	2,123	SH		DFND		0	0	2,123
OMEGA HEALTHCARE INVS INC	COM	681936100	11,252	367	SH		DFND		0	0	367
ORACLE CORP	COM	68389X105	4,333,489	41,103	SH		DFND		0	0	41,103
OUSTER INC	COM	68989M103	20,180	2,631	SH		DFND		0	0	2,631
OWENS CORNING NEW	COM	690742101	5,485	37	SH		DFND		0	0	37
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	8,809	898	SH		DFND		0	0	898
PAGSEGURO DIGITAL LTD	COM CL A	G68707101	2,965,123	232,924	SH		DFND		0	0	232,924
PAMPA ENERGIA S A	SPONS ADR LVL I	697660207	2,432,500	50,000	SH		DFND		0	0	50,000
PAYPAL HLDGS INC	COM	70450Y103	525,915	8,564	SH		DFND		1,036	0	7,528
PENTAIR PLC	SHS	G7S00T104	5,599	77	SH		DFND		0	0	77
PEPSICO INC	COM	713448108	56,727	334	SH		DFND		0	0	334
PERKINELMER INC	COM	714046109	95,646	875	SH		DFND		0	0	875
PETROLEO BRASILEIRO SA PETRO	SP ADR NON VTG	71654V101	40,774,395	2,658,044	SH		DFND		551,286	0	2,106,758
PETROLEO BRASILEIRO SA PETRO	SP ADR NON VTG	71654V101	70,555,241	4,599,429	SH		DFND	1	740,498	0	3,858,931
PETROLEO BRASILEIRO SA PETRO	SPONSORED ADR	71654V408	88,642,303	5,519,446	SH		DFND		4,466,048	0	1,053,398
PETROLEO BRASILEIRO SA PETRO	SPONSORED ADR	71654V408	41,829,812	2,604,596	SH		DFND	1	400,065	0	2,204,531
PINDUODUO INC	SPONSORED ADS	722304102	555,978	3,800	SH		DFND		0	0	3,800
PINDUODUO INC	SPONSORED ADS	722304102	555,978	3,800	SH		DFND	1	3,800	0	0
PLANET LABS PBC	COM CL A	72703X106	19,881	8,049	SH		DFND		0	0	8,049
PLUG POWER INC	COM NEW	72919P202	76,446	16,988	SH		DFND		0	0	16,988
PROCTER AND GAMBLE CO	COM	742718109	51,289	350	SH		DFND		0	0	350
PUBLIC SVC ENTERPRISE GROUP	COM	744573106	1,095,074	17,908	SH		DFND		17,908	0	0
QUALCOMM INC	COM	747525103	7,584,720	52,000	SH		DFND		0	0	52,000
QUEST DIAGNOSTICS INC	COM	74834L100	17,924	130	SH		DFND		0	0	130
QUIDELORTHO CORP	COM	219798105	7,370	100	SH		DFND		0	0	100
RAYONIER INC	COM	754907103	7,918	237	SH		DFND		0	0	237
RECURSION PHARMACEUTICALS IN	CL A	75629V104	31,167	3,161	SH		DFND		0	0	3,161
REGENERON PHARMACEUTICALS	COM	75886F107	126,474	144	SH		DFND		0	0	144
REKOR SYSTEMS INC	COM	759419104	21,042	6,319	SH		DFND		0	0	6,319
RELIANCE STEEL & ALUMINUM CO	COM	759509102	241,250	3,860	SH		DFND		0	0	3,860
REPLIGEN CORP	COM	759916109	12,946	72	SH		DFND		0	0	72
REPUBLIC SVCS INC	COM	760759100	35,456	215	SH		DFND		0	0	215
REVOLUTION MEDICINES INC	COM	76155X100	9,292	324	SH		DFND		0	0	324
RIDGEBIO PHARMA INC COM	COM	10806X102	10,496	260	SH		DFND		0	0	260
ROBINHOOD MKTS INC	COM CL A	770700102	26,512	2,081	SH		DFND		0	0	2,081
ROBLOX CORP	CL A	771049103	1,255,837	27,468	SH		DFND		27,468	0	0
ROCKWELL AUTOMATION INC	COM	773903109	15,551,322	50,088	SH		DFND		0	0	50,088
ROIVANT SCIENCES LTD	SHS	G76279101	26,873	2,393	SH		DFND		0	0	2,393
ROSS STORES INC	COM	778296103	2,173,553	15,706	SH		DFND		0	0	15,706
RUMBLE INC	COM CL A	78137L105	22,944	5,110	SH		DFND		0	0	5,110
S&P GLOBAL INC	COM	78409V104	3,229,850	7,310	SH		DFND		0	0	7,310
SAREPTA THERAPEUTICS INC	COM	803607100	16,297	169	SH		DFND		0	0	169
SEA LTD	ADR	81141R100	47,223	1,166	SH		DFND		0	0	1,166
SELECT SECTOR SPDR TR	TECHNOLOGY	81369Y803	1,482,096	7,700	SH		DFND		0	0	7,700
SELECT SECTOR SPDR TR	SBI CONS DISCR	81369Y407	634,954	3,551	SH		DFND		0	0	3,551
SENTINELONE INC	CL A	81730H109	27,660	1,008	SH		DFND		0	0	1,008
SHELL PLC	SPON ADS	780259305	73,762	1,121	SH		DFND		0	0	1,121
SNAP INC	CL A	83304A106	26,885	1,588	SH		DFND		0	0	1,588
SNOWFLAKE INC	CL A	833445109	9,439,963	47,437	SH		DFND		688	0	46,749
SOCIEDAD QUIMICA MINERA DE C	SPON ADR SER B	833635105	23,871,338	410,900	SH		DFND		0	0	410,900
SOCIEDAD QUIMICA MINERA DE C	SPON ADR SER B	833635105	44,853,947	772,076	SH		DFND	1	83,327	0	688,749
SONY CORP	SPONSORED ADR	835699307	232,369	2,454	SH		DFND		0	0	2,454
SOUTHWEST AIRLS CO	COM	844741108	1,704,040	58,000	SH		DFND		0	0	58,000
SPDR GOLD TR	GOLD SHS	78463V107	19,308,170	101,000	SH		DFND		0	0	101,000
SPDR INDEX SHS FDS	ASIA PACIF ETF	78463X301	1,263,324	12,500	SH		DFND		0	0	12,500
SPDR S&P 500 ETF TR	TR UNIT	78462F103	249,548,682	525,023	SH		DFND	1	525,023	0	0
SPDR SER TR	S&P OILGAS EXP	78468R556	1,750,264	12,835	SH		DFND		0	0	12,835
SPDR SERIES TRUST	S&P METALS MNG	78464A755	230,060	3,885	SH		DFND		0	0	3,885
SPDR SERIES TRUST	S&P BK ETF	78464A797	264,799	5,754	SH		DFND		0	0	5,754
SPDR SERIES TRUST	S&P RETAIL ETF	78464A714	4,990,051	69,229	SH		DFND		0	0	69,229
SPLUNK INC	COM	848637104	456,180	3,000	SH		DFND		0	0	3,000
SQUARE INC	CL A	852234103	18,487	239	SH		DFND		0	0	239
SQUARESPACE INC	CLASS A	85225A107	27,431	831	SH		DFND		0	0	831
STARBUCKS CORP	COM	855244109	16,226	169	SH		DFND		0	0	169
STEEL DYNAMICS INC	COM	858119100	25,864	219	SH		DFND		0	0	219
STERICYCLE INC	COM	858912108	5,253	106	SH		DFND		0	0	106
SUNRUN INC	COM	86771W105	7,616	388	SH		DFND		0	0	388
SUZANO S A SPON	COM	86959K105	1,304,877	115,629	SH		DFND		0	0	115,629
SUZANO S A SPON	COM	86959K105	18,328,152	1,624,112	SH		DFND	1	361,406	0	1,262,706
T MOBILE US INC	COM	872590104	33,830	211	SH		DFND		0	0	211
TAIWAN SEMICONDUCTOR MFG LTD	SPONSORED ADR	874039100	47,071,544	452,611	SH		DFND		0	0	452,611
TAIWAN SEMICONDUCTOR MFG LTD	SPONSORED ADR	874039100	1,164,800	11,200	SH		DFND	1	11,200	0	0
TAKE-TWO INTERACTIVE SOFTWAR	COM	874054109	10,623	66	SH		DFND		0	0	66
TARGET CORP	COM	87612E106	12,818	90	SH		DFND		0	0	90
TECHNIPFMC PLC	COM	G87110105	69,846	3,468	SH		DFND		0	0	3,468
TECK RESOURCES LTD	CL B	878742204	4,618,985	108,376	SH		DFND		0	0	108,376
TELADOC HEALTH INC	COM	87918A105	13,339	619	SH		DFND		0	0	619
TELEFONICA BRASIL SA	SPONSORED ADR	87936R205	981,887	92,500	SH		DFND		0	0	92,500
TELEFONICA BRASIL SA	SPONSORED ADR	87936R205	2,596,428	244,600	SH		DFND	1	32,800	0	211,800
TETRA TECH INC NEW	COM	88162G103	5,843	35	SH		DFND		0	0	35
TG THERAPEUTICS INC	COM	88322Q108	3,245	190	SH		DFND		0	0	190
THE TRADE DESK INC	COM CL A	88339J105	16,263	226	SH		DFND		0	0	226
THERMO FISHER SCIENTIFIC INC	COM	883556102	3,105,448	5,828	SH		DFND		0	0	5,828
TIM S A	COM	88706T108	383,298	20,812	SH		DFND		0	0	20,812
TIM S A	COM	88706T108	8,182,304	444,276	SH		DFND	1	108,331	0	335,945
TOPBUILD CORP	COM	89055F103	7,111	19	SH		DFND		0	0	19
TREX CO INC	COM	89531P105	5,878	71	SH		DFND		0	0	71
TRIP COM GROUP LTD	ADS	89677Q107	226,863	6,300	SH		DFND		0	0	6,300
TRIP COM GROUP LTD	ADS	89677Q107	226,863	6,300	SH		DFND	1	6,300	0	0
TUSIMPLE HLDGS INC	CL A	90089L108	6,376	7,264	SH		DFND		0	0	7,264
UDR INC	COM	902653104	821,924	21,200	SH		DFND		0	0	21,200
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	12,959	271	SH		DFND		0	0	271
UNION PAC CORP	COM	907818108	6,231,987	25,333	SH		DFND		0	0	25,333
UNITED CONTL HLDGS INC	COM	910047109	3,399,570	81,000	SH		DFND		0	0	81,000
UNITED STATES OIL FUND LP	UNITS	91232N108	6,098,475	91,500	SH		DFND		0	0	91,500
UNITEDHEALTH GROUP INC	COM	91324P102	99,503	189	SH		DFND		0	0	189
UNITY SOFTWARE INC	COM	91332U101	30,504	746	SH		DFND		0	0	746
UNIVERSAL DISPLAY CORP	COM	91347P105	33,662	176	SH		DFND		0	0	176
UPSTART HLDGS INC	COM	91680M107	28,112	688	SH		DFND		0	0	688
VALE S A	SPONSORED ADS	91912E105	72,596,298	4,560,069	SH		DFND		0	0	4,560,069
VALE S A	SPONSORED ADS	91912E105	102,354,154	6,429,281	SH		DFND	1	929,105	0	5,500,176
VANECK VECTORS ETF TR	SEMICONDUCTOR ET	92189F676	16,077,898	91,942	SH		DFND		0	0	91,942
VANECK VECTORS ETF TR	JR GOLD MINERS E	92189F791	1,516,400	40,000	SH		DFND		40,000	0	0
VANGUARD INDEX FDS	S&P 500 ETF SHS	922908363	121,004,520	277,025	SH		DFND		0	0	277,025
VANGUARD INTL EQUITY INDEX F	FTSE EUROPE ETF	922042874	363,925	5,644	SH		DFND		0	0	5,644
VANGUARD INTL EQUITY INDEX F	FTSE EUROPE ETF	922042874	49,471,184	767,233	SH		DFND	1	767,233	0	0
VERACYTE INC	COM	92337F107	4,154	151	SH		DFND		0	0	151
VERIZON COMMUNICATIONS INC	COM	92343V104	22,695	602	SH		DFND		0	0	602
VERTEX PHARMACEUTICALS INC	COM	92532F100	135,494	333	SH		DFND		0	0	333
VERVE THERAPEUTICS INC	COM	92539P101	26,179	1,878	SH		DFND		0	0	1,878
VESTA REAL ESTATE CORPORATIO	ADS	92540K109	1,600,157	40,408	SH		DFND		0	0	40,408
VIMEO INC	COMMON STOCK	92719V100	19,420	4,954	SH		DFND		0	0	4,954
VIRGIN GALACTIC HOLDINGS INC	COM	92766K106	28,449	11,612	SH		DFND		0	0	11,612
VISA INC	COM CL A	92826C839	3,972,345	15,258	SH		DFND		0	0	15,258
VORNADO RLTY TR	SH BEN INT	929042109	8,729	309	SH		DFND		0	0	309
VUZIX CORP	COM NEW	92921W300	8,667	4,157	SH		DFND		0	0	4,157
WABTEC CORP	COM	929740108	14,086	111	SH		DFND		0	0	111
WALMART INC	COM	931142103	67,001	425	SH		DFND		0	0	425
WASTE MGMT INC DEL	COM	94106L109	77,013	430	SH		DFND		0	0	430
WATERS CORP	COM	941848103	71,443	217	SH		DFND		0	0	217
WESTLAKE CHEM CORP	COM	960413102	84,396	603	SH		DFND		0	0	603
WEYERHAEUSER CO	COM	962166104	44,610	1,283	SH		DFND		0	0	1,283
WISDOMTREE TR	INDIA ERNGS FD	97717W422	902,000	22,000	SH		DFND		0	0	22,000
WOLFSPEED INC	COM	977852102	18,274	420	SH		DFND		0	0	420
WORTHINGTON INDS INC	COM	981811102	85,059	1,478	SH		DFND		0	0	1,478
XP INC	CL A	G98239109	11,061,238	421,886	SH		DFND		0	0	421,886
XP INC	CL A	G98239109	708,858	29,700	SH		DFND	1	0	0	29,700
XPERI HOLDING CORP	COMMON STOCK	98423J101	12,640	1,147	SH		DFND		0	0	1,147
XYLEM INC	COM	98419M100	13,037	114	SH		DFND		0	0	114
YPF SOCIEDAD ANONIMA	SPON ADR CL D	984245100	2,007,180	118,000	SH		DFND		0	0	118,000
YUM BRANDS INC	COM	988498101	18,554	142	SH		DFND		0	0	142
ZIM INTEGRATED SHIPPING SERV	SHS	M9T951109	141,141	14,300	SH		DFND		0	0	14,300
ZIM INTEGRATED SHIPPING SERV	SHS	M9T951109	141,141	14,300	SH		DFND	1	14,300	0	0
ZOOM VIDEO COMMUNICATIONS IN	CL A	98980L101	447,784	6,227	SH		DFND		5,286	0	941