Exhibit 16.1
September 30, 2010
Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549-7561
Commissioners:
We have read Item 4.01 of Form 8-K of Pro-Pharmaceuticals, Inc. dated September 29, 2010, expected to be filed with the Securities and Exchange Commission on September 30, 2010 and are in agreement with the statements concerning our Firm.
We have no basis to agree or disagree with the other statements included in such Form 8-K.
Very truly yours,
CATURANO AND COMPANY, INC.
Boston, Massachusetts
80 City Square Boston. MA 02129-3742 P 617.912.9000 F 617.912.9001 www.caturano.com
Assurance— Business Risk & Controls— Tax— Management & Technology Consulting— Wealth Management
An Independent Member of Baker Tilly International