Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” in Amendment No. 1 to the Registration Statement (Form S-3 No. 333-183538) and the related Prospectus of Zalicus Inc. and to the incorporation by reference therein of our reports dated March 9, 2012, with respect to the consolidated financial statements of Zalicus Inc., and the effectiveness of internal control over financial reporting of Zalicus Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2011, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Boston, Massachusetts
September 4, 2012
