Madrigal Pharmaceuticals (MDGL) 10-Q 4 Aug 22 2022 Q2 Quarterly report Financial data

Cover Page

Cover Page - shares	6 Months Ended
	Jun. 30, 2022	Aug. 01, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Transition Report	false
Entity Interactive Data Current	Yes
Amendment Flag	false
Document Fiscal Year Focus	2022
Document Period End Date	Jun. 30, 2022
Document Fiscal Period Focus	Q2
Entity Registrant Name	MADRIGAL PHARMACEUTICALS, INC.
Entity Central Index Key	0001157601
Entity File Number	001-33277
Current Fiscal Year End Date	--12-31
Entity Tax Identification Number	04-3508648
Entity Incorporation, State or Country Code	DE
Entity Current Reporting Status	Yes
Entity Filer Category	Large Accelerated Filer
Entity Emerging Growth Company	false
Entity Small Business	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		17,103,395
City Area Code	267
Local Phone Number	824-2827
Trading Symbol	MDGL
Security Exchange Name	NASDAQ
Title of 12(b) Security	Common Stock, $0.0001 Par Value Per Share
Entity Address, Address Line One	Four Tower Bridge
Entity Address, Address Line Two	200 Barr Harbor Drive, Suite 200
Entity Address, City or Town	West Conshohocken
Entity Address, Postal Zip Code	19428
Entity Address, State or Province	PA

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 53,272	$ 36,269
Marketable securities	158,494	234,077
Prepaid expenses and other current assets	2,780	1,338
Total current assets	214,546	271,684
Property and equipment, net	789	851
Right-of-use asset	1,057	797
Total assets	216,392	273,332
Current liabilities:
Accounts payable	11,294	21,380
Accrued expenses	71,836	55,048
Lease liability	879	410
Total current liabilities	84,009	76,838
Long term liabilities:
Loan payable, net of discount	48,670	0
Lease liability	178	387
Total long term liabilities	48,848	387
Total liabilities	132,857	77,225
Stockholders' equity:
Preferred stock, par value $0.0001 per share authorized: 5,000,000 shares at June 30, 2022 and December 31, 2021; 1,969,797 shares issued and outstanding at June 30, 2022 and December 31, 2021
Common stock, par value $0.0001 per share authorized: 200,000,000 at June 30, 2022 and December 31, 2021; 17,103,395 shares issued and outstanding at June 30, 2022 and December 31, 2021	2	2
Additional paid-in-capital	879,538	863,495
Accumulated other comprehensive loss	(447)	(80)
Accumulated deficit	(795,558)	(667,310)
Total stockholders' equity	83,535	196,107
Total liabilities and stockholders' equity	$ 216,392	$ 273,332

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	1,969,797	1,969,797
Preferred stock, shares outstanding	1,969,797	1,969,797
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares issued	17,103,395	17,103,395
Common stock, shares outstanding	17,103,395	17,103,395

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Total revenues
Operating expenses:
Research and development	58,499	51,632		106,428	97,402
General and administrative	11,774	10,110		21,432	17,319
Total operating expenses	70,273	61,742		127,860	114,721
Loss from operations	(70,273)	(61,742)		(127,860)	(114,721)
Interest income	323	91		392	251
Interest expense	(780)	0		(780)	0
Other income		0			273
Net loss	$ (70,730)	$ (61,651)	$ (52,546)	$ (128,248)	$ (114,197)
Net loss per common share:
Earnings Per Share, Basic	$ (4.14)	$ (3.72)		$ (7.5)	$ (7.05)
Earnings Per Share, Diluted	$ (4.14)	$ (3.72)		$ (7.5)	$ (7.05)
Weighted Average Number of Shares Outstanding, Basic	17,103,395	16,571,322		17,103,395	16,207,880
Weighted Average Number of Shares Outstanding, Diluted	17,103,395		16,571,322	17,103,395	16,207,880

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Statement of Comprehensive Income [Abstract]
Net loss	$ (70,730)	$ (61,651)	$ (128,248)	$ (114,197)
Other comprehensive income (loss):
Unrealized gain (loss) on available-for-sale securities	(45)	29	(367)	(32)
Comprehensive loss	$ (70,775)	$ (61,622)	$ (128,615)	$ (114,229)

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock	Common stock	Additional paid-in Capital	Accumulated other comprehensive income (loss)	Accumulated deficit
Balance at Dec. 31, 2020	$ 239,970		$ 2	$ 665,385	$ 47	$ (425,464)
Balance (in shares) at Dec. 31, 2020		1,969,797	15,508,146
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	66,616		$ 0	66,616
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			550,803
Sale of common shares to related parties and exercise of common stock options, net of transaction costs	478			478
Sale of common shares to related parties and exercise of common stock options, net of transaction costs ( in shares)			4,250
Compensation expense related to stock options for services	6,096			6,096
Unrealized gain (loss) on marketable securities	(61)				(61)
Net loss	(52,546)					(52,546)
Balance at Mar. 31, 2021	260,553		$ 2	738,575	(14)	(478,010)
Balance (in shares) at Mar. 31, 2021		1,969,797	16,063,199
Balance at Dec. 31, 2020	239,970		$ 2	665,385	47	(425,464)
Balance (in shares) at Dec. 31, 2020		1,969,797	15,508,146
Increase (Decrease) in Stockholders' Equity
Unrealized gain (loss) on marketable securities	(32)
Net loss	(114,197)
Balance at Jun. 30, 2021	270,651		$ 2	810,295	15	(539,661)
Balance (in shares) at Jun. 30, 2021		1,969,797	16,599,522
Balance at Mar. 31, 2021	260,553		$ 2	738,575	(14)	(478,010)
Balance (in shares) at Mar. 31, 2021		1,969,797	16,063,199
Increase (Decrease) in Stockholders' Equity
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs	63,541		$ 0	63,541
Issuance of common shares in equity offering, excluding to related parties, net of transaction costs (in shares)			536,323
Compensation expense related to stock options for services	8,179			8,179
Unrealized gain (loss) on marketable securities	29				29
Net loss	(61,651)					(61,651)
Balance at Jun. 30, 2021	270,651		$ 2	810,295	15	(539,661)
Balance (in shares) at Jun. 30, 2021		1,969,797	16,599,522
Balance at Dec. 31, 2021	$ 196,107		$ 2	863,495	(80)	(667,310)
Balance (in shares) at Dec. 31, 2021	17,103,395	1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Compensation expense related to stock options for services	$ 7,477			7,477
Unrealized gain (loss) on marketable securities	(322)				(322)
Net loss	(57,518)					(57,518)
Balance at Mar. 31, 2022	145,744		$ 2	870,972	(402)	(724,828)
Balance (in shares) at Mar. 31, 2022		1,969,797	17,103,395
Balance at Dec. 31, 2021	$ 196,107		$ 2	863,495	(80)	(667,310)
Balance (in shares) at Dec. 31, 2021	17,103,395	1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Unrealized gain (loss) on marketable securities	$ (367)
Net loss	(128,248)
Balance at Jun. 30, 2022	$ 83,535		$ 2	879,538	(447)	(795,558)
Balance (in shares) at Jun. 30, 2022	17,103,395	1,969,797	17,103,395
Balance at Mar. 31, 2022	$ 145,744		$ 2	870,972	(402)	(724,828)
Balance (in shares) at Mar. 31, 2022		1,969,797	17,103,395
Increase (Decrease) in Stockholders' Equity
Compensation expense related to stock options for services	7,944			7,944
Unrealized gain (loss) on marketable securities	(45)				(45)
Issuance of warrants	622			622
Net loss	(70,730)					(70,730)
Balance at Jun. 30, 2022	$ 83,535		$ 2	$ 879,538	$ (447)	$ (795,558)
Balance (in shares) at Jun. 30, 2022	17,103,395	1,969,797	17,103,395

Condensed Consolidated Statem_4

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (128,248)	$ (114,197)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	15,421	14,275
Depreciation and amortization expense	217	202
Amortization of debt issuance costs and discount	178	0
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(1,442)	(1,208)
Accounts payable	(10,086)	50
Accrued expense	16,788	10,018
Accrued interest, net of interest received on maturity of investments	(101)	550
Net cash used in operating activities	(107,273)	(90,310)
Cash flows from investing activities:
Purchases of marketable securities	(116,496)	(224,071)
Sales and maturities of marketable securities	191,813	163,328
Purchases of property and equipment, net of disposals	(155)	(46)
Net cash provided by (used in) investing activities	75,162	(60,789)
Cash flows from financing activities:
Proceeds from issuances of stock, excluding related parties, net of transaction costs	0	130,157
Proceeds from the exercise of common stock options	0	478
Proceeds from issuance of loan payable	50,000	0
Payment of debt issuance costs	(886)	0
Net cash provided by financing activities	49,114	130,635
Net increase (decrease) in cash and cash equivalents	17,003	(20,464)
Cash and cash equivalents at beginning of period	36,269	54,004
Cash and cash equivalents at end of period	53,272	33,540
Supplemental disclosure of cash flow information:
Obtaining a right-of-use asset in exchange for a lease liability	$ 583	$ 376

Organization, Business and Basi

Organization, Business and Basis of Presentation	6 Months Ended
	Jun. 30, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Business and Basis of Presentation	1. Organization, Business, and Basis of Presentation Organization and Business Madrigal Pharmaceuticals, Inc. (the “Company” or “Madrigal”) is a clinical-stage biopharmaceutical company pursuing novel therapeutics for nonalcoholic steatohepatitis (NASH), a liver disease with high unmet medical need. Madrigal’s lead candidate, resmetirom, is a once daily, oral, thyroid hormone receptor (THR)-ß selective agonist designed to target key underlying causes of NASH in the liver. Resmetirom is currently being evaluated in two Phase 3 clinical studies (MAESTRO-NASH and MAESTRO-NAFLD-1) MAESTRO-NAFLD-1 Basis of Presentation Certain information and footnote disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) have been condensed or omitted. Accordingly, the unaudited condensed consolidated financial statements do not include all information and footnotes required by GAAP for complete annual financial statements. However, we believe that the disclosures included in these financial statements are adequate to make the information presented not misleading. The unaudited condensed consolidated financial statements, in the opinion of management, reflect all adjustments, which include normal recurring adjustments, necessary for a fair statement of such interim results. The interim results are not necessarily indicative of the results that we will have for the full year ending December 31, 2022 or any subsequent period. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the notes to those statements for the year ended December 31, 2021.

Summary of Significant Accounti

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies Principle of Consolidation The consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances have been eliminated in consolidation. Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, and the reported amounts of revenues and expenses during the reporting periods. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates. Cash and Cash Equivalents The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase to be cash equivalents. The Company maintains its cash in bank accounts, the balance of which, at times, exceeds Federal Deposit Insurance Corporation insured limits. The primary objective of the Company’s investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company’s cash is deposited in highly rated financial institutions in the United States. The Company invests in money market funds and high-grade, commercial paper and corporate bonds, which management believes are subject to minimal credit and market risk. Marketable Securities Marketable securities consist of investments in high-grade corporate obligations and government and government agency obligations that are classified as available-for-sale. The Company adjusts the cost of available-for-sale available-for-sale Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive income or loss, which is a separate component of stockholders’ equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the six months ended June 30, 2022 and 2021, the Company did not have any realized gains or losses on marketable securities. Fair Value of Financial Instruments The carrying amounts of the Company’s financial instruments, which include cash equivalents and marketable securities, approximate their fair values. The fair value of the Company’s financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels: Level 1—quoted prices in active markets for identical assets and liabilities. Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active. Level 3—unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Financial assets and liabilities are classified in their entirety within the fair value hierarchy based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third- party pricing sources. The pricing services utilize industry standard valuation models, including both income and market based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. As of June 30, 2022, the Company’s financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund, its financial assets valued based on Level 2 inputs consisted of high-grade corporate and government agency bonds and commercial paper, and it had no financial assets valued based on Level 3 inputs. During the six months ended June 30, 2022 and 2021, the Company did not have any transfers of financial assets between Levels 1 and 2. As of June 30, 2022 and December 31, 2021, the Company did not have any financial liabilities that were recorded at fair value on a recurring basis on the balance sheet. Research and Development Costs Research and development costs are expensed as incurred. Research and development costs are comprised of costs incurred in performing research and development activities, including internal costs (including stock-based compensation), costs for consultants, milestone payments under licensing agreements, and other costs associated with the Company’s preclinical and clinical programs. In particular, the Company has conducted safety studies in animals, optimized and implemented the manufacturing of our drug, and conducted Phase 1-3 Patents Costs to secure and defend patents are expensed as incurred and are classified as general and administrative expense in the Company’s consolidated statements of operations. Stock-Based Compensation The Company recognizes stock-based compensation expense based on the grant date fair value of stock options granted to employees, officers, and directors. The Company uses the Black-Scholes option pricing model to determine the grant date fair value as management believes it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. The expected lives for options granted represent the period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options. Expected volatility is based upon an industry estimate or blended rate including the Company’s historical trading activity. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The Company estimates the forfeiture rate based on historical data. This analysis is re-evaluated Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (“ISOs”). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for its share-based compensation arrangements due to the fact that the Company does not believe it is more likely than not it will realize the related deferred tax assets. Income Taxes The Company uses the asset and liability method to account for income taxes. Deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the Company’s financial statement carrying amounts and the tax basis of assets and liabilities using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. The Company currently maintains a 100% valuation allowance on its deferred tax assets. Comprehensive Loss Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner Basic and Diluted Loss Per Common Share Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding any restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the six months ended June 30, 2022 and 2021, diluted net loss per share is the same as basic net loss per share because the inclusion of weighted average shares of unvested restricted common stock, common stock issuable upon the exercise of stock options, and common stock issuable upon the conversion of preferred stock would be anti-dilutive. The following table summarizes outstanding securities not included in the computation of diluted net loss per common share, as their inclusion would be anti-dilutive: Six Months Ended June 30, 2022 2021 Common stock options 2,976,545 2,268,787 Preferred stock 1,969,797 1,969,797 Warrants 14,899 — Recent Accounting Pronouncements None

Liquidity and Uncertainties

Liquidity and Uncertainties	6 Months Ended
	Jun. 30, 2022
Liquidity and Uncertainties
Liquidity and Uncertainties	3. Liquidity and Uncertainties The Company is subject to risks common to development stage companies in the biopharmaceutical industry including, but not limited to, uncertainty of product development and commercialization, dependence on key personnel, uncertainty of market acceptance of products and product reimbursement, product liability, uncertain protection of proprietary technology, potential inability to raise additional financing necessary for development and commercialization, and compliance with the U.S. Food and Drug Administration (FDA) and other government regulations. The Company has incurred losses since inception, including approximately $128.2 million for the six months ended June 30, 2022, resulting in an accumulated deficit of approximately $795.6 million as of June 30, 2022. Management expects to incur losses for the foreseeable future. To date, the Company has funded its operations primarily through proceeds from sales of the Company’s capital stock. In addition, the Company entered into a Loan and Security Agreement (the “Loan ”) and the several banks and other financial institutions or entities party thereto which provides subject to the Company’s achievement of certain milestones. The million tranche was drawn at closing (see Note 6 – Long Term Debt). The Company believes that its cash, cash equivalents and marketable securities at June 30, 2022 will be sufficient to fund operations past one year from the issuance of these financial statements. To meet its future capital needs, the Company intends to raise additional capital through debt or equity financings, collaborations, partnerships or other strategic transactions. However, there can be no assurance that the Company will be able to complete any such transactions on acceptable terms or otherwise. The inability of the Company to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on the Company’s business, results of operations and financial condition. The Company has the ability to delay certain research activities and related clinical expenses if necessary due to liquidity concerns until a date when those concerns are relieved.

Cash, Cash Equivalents and Mark

Cash, Cash Equivalents and Marketable Securities	6 Months Ended
	Jun. 30, 2022
Cash and Cash Equivalents [Abstract]
Cash, Cash Equivalents and Marketable Securities	4. Cash, Cash Equivalents and Marketable Securities A summary of cash, cash equivalents and available-for-sale June 30, 2022 Unrealized Unrealized Fair Cost gains losses Value Cash and cash equivalents: Cash (Level 1) $ 1,728 $ — $ — $ 1,728 Money market funds (Level 1) 37,809 — — 37,809 Corporate debt securities due within 3 months of date of purchase (Level 2) 13,735 — — 13,735 Total cash and cash equivalents 53,272 — — 53,272 Marketable securities: Corporate debt securities due within 1 year of date of purchase (Level 2) 152,923 1 (431 ) 152,493 U.S. government and government sponsored entities due within 1 year of date of purchase (Level 2) 6,018 — (17 ) 6,001 Total cash, cash equivalents and marketable securities $ 212,213 $ 1 $ (448 ) $ 211,766 December 31, 2021 Unrealized Unrealized Fair Cost gains losses Value Cash and cash equivalents: Cash (Level 1) $ 18,877 $ — $ — $ 18,877 Money market funds (Level 1) 17,392 — — 17,392 Total cash and cash equivalents 36,269 — — 36,269 Marketable securities: Corporate debt securities due within 1 year of date of purchase (Level 2) 228,348 6 (66 ) 228,288 Corporate debt securities due within 1 to 2 years of date of purchase (Level 2) 5,809 — (20 ) 5,789 Total cash, cash equivalents and marketable securities $ 270,426 $ 6 $ (86 ) $ 270,346

Accrued Liabilities

Accrued Liabilities	6 Months Ended
	Jun. 30, 2022
Accrued Liabilities, Current [Abstract]
Accrued Liabilities	5. Accrued Liabilities Accrued liabilities as of June 30, 2022 and December 31, 2021 consisted of the following (in thousands): June 30, December 31, 2022 2021 Contract research organization costs $ 57,288 $ 38,349 Other clinical study related costs 4,369 3,957 Compensation and benefits 3,577 6,769 Professional fees 3,959 2,455 Other 2,643 3,518 Total accrued liabilities $ 71,836 $ 55,048

Long Term Debt

Long Term Debt	6 Months Ended
	Jun. 30, 2022
Debt Disclosure [Abstract]
Long Term Debt	6. Long Term Debt In May 2022 the Company and its wholly-owned subsidiary, Canticle Pharmaceuticals, Inc., entered into the million Loan Facility with the several banks and other financial institutions or entities party thereto (each, a “Lender” and collectively referred to as the “Lenders”), and Hercules Capital, Inc. (“Hercules”), in its capacity as administrative agent and collateral agent for itself and the Lenders. Under the terms of the Loan Facility, the first million tranche was drawn at closing. The Company may also draw up to an additional million in two separate tranches upon achievement of certain resmetirom clinical and regulatory milestones. A fourth tranche of million may be drawn by the Company, subject to the approval of Hercules. The Loan Facility has a minimum interest rate of 7.45% and adjusts with changes in the prime rate. and if the Company maintains compliance with applicable covenants. The Loan Facility matures in May 2026 and may be extended an additional year upon the achievement of certain clinical and regulatory milestones. The Loan Facility is secured by a security interest in substantially all of the Company’s assets, other than intellectual property. It includes an end of term charge of the aggregate principal amount, which is accounted for in the loan discount. In connection with the first tranche drawn at closing, the Company issued Hercules a warrant to purchase 14,899 shares, which had a Black-Scholes value of $0.6 million. Additional details of the Loan Facility were filed with the Securities and Exchange Commission (“SEC”) on a Current Report on Form 8-K 10-Q. The Loan Facility includes affirmative and restrictive financial covenants commencing on January 1, 2023, including maintenance of a minimum cash, cash equivalents and liquid funds covenant of $35.0 million, which may decrease in certain circumstances if the Company achieves certain clinical milestones and a revenue milestone, and a revenue-based covenant that could apply commencing at or after the time that financial reporting is due for the quarter ending September 30, 2024. The Loan Facility also includes customary covenants associated with a secured loan facility, including covenants concerning financial reporting obligations, and certain limitations on indebtedness, liens (including a negative pledge on intellectual property and other assets), investments, distributions (including dividends), collateral, investments, distributions, transfers, mergers or acquisitions, taxes, corporate changes, and deposit accounts. As of June 30, 2022, the outstanding principal under the Loan Facility was $50.0 million. The interest rate as of June 30, 2022 was 8.70%. As of June 30, 2022, the Company was in compliance with all loan covenants and provisions. Future minimum payments, including interest and principal, under the loans payable outstanding as of June 30, 2022 are as follows (in thousands): Period Ending June 30, 2022: Amount 2022 (remaining six months) $ 2,196 2023 4,410 2024 9,338 Thereafter 50,782 $ 66,726 Less amount representing interest (14,051 ) Less unamortized discount (4,005 ) Loans payable, net of discount $ 48,670

Stockholders' Equity

Stockholders' Equity	6 Months Ended
	Jun. 30, 2022
Stockholders' Equity Note [Abstract]
Stockholders' Equity	7. Stockholders’ Equity Common Stock Each common stockholder generally is entitled to one vote for each share of common stock held, subject to limitations as may be established for certain other classes and series of stock of the Company from time to time. Each share of common stock is entitled to receive dividends, as and when declared by the Company’s board of directors. The Company has never declared cash dividends on its common stock and does not expect to do so in the foreseeable future. Preferred Stock The Company’s Series A Convertible Preferred Stock (“Series A Preferred Stock”) has a par value of $0.0001 per share and is convertible into shares of the Common Stock at a one-to-one winding-up as-if-converted-to-Common-Stock as-converted At-The-Market In November 2020, the Company entered into an at-the-market “at-the-market” Under the 2020 Sales Agreement the Company sold 1,126,733 shares for an aggregate of approximately $137.4 million in gross proceeds, with net proceeds to the Company of approximately $134.8 million after deducting commissions and other transaction costs. Of those shares sold, 1,087,126 were sold in 2021. In June 2021, the Company filed with the SEC and had declared effective a new shelf registration statement on Form S-3 at-the-market at the Company’s option, through Cowen as its sales agent. The 2021 Sales Agreement supersedes the 2020 Sales Agreement. Subject to the terms and conditions of the 2021 Sales Agreement, Cowen will use commercially reasonable efforts consistent with its normal trading and sales practices to sell the common stock based upon the Company’s instructions (including any price, time or size limits or other customary parameters or conditions the Company may impose). As of June 30, 2022, shares had been sold under the 2021 Sales Agreement for an aggregate of approximately $ million in gross proceeds, with net proceeds to the Company of approximately $ million after deducting commissions and other transaction costs. All of those shares were sold in 2021. As of June 30, 2022, $ million remained reserved and available for sale under the 2021 Sales Agreement and the Company’s related prospectus supplement.

Stock-based Compensation

Stock-based Compensation	6 Months Ended
	Jun. 30, 2022
Share-based Payment Arrangement [Abstract]
Stock-based Compensation	8. Stock-based Compensation The Company’s 2015 Stock Plan, as amended, is our primary equity incentive compensation plan through which equity based grants are awarded. The 2015 Stock Plan provides for the grant of incentive stock options, non-statutory The following table summarizes stock option activity during the six months ended June 30, 2022: Shares Weighted Outstanding at January 1, 2022 2,301,574 $ 78.90 Options granted 736,395 83.35 Options cancelled (61,424 ) 100.82 Outstanding at June 30, 2022 2,976,545 $ 79.54 Exercisable at June 30, 2022 1,669,315 $ 69.41 The total cash received by the Company as a result of stock option exercises was $0 million and $0.5 million, respectively, for the six months ended June 30, 2022 and 2021. The total intrinsic value of options exercised was $0 million and $0.1 million, respectively, for the six months ended June 30, 2022 and 2021. The weighted-average grant date fair values, based on the Black-Scholes option model, of options granted during the six months ended June 30, 2022 and 2021 were $55.84 and $78.34, respectively. Stock-Based Compensation Expense Stock-based compensation expense during the six months ended June 30, 2022 and 2021 was as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Stock-based compensation expense by type of award: Stock options $ 7,944 $ 8,179 $ 15,421 $ 14,275 Total stock-based compensation expense $ 7,944 $ 8,179 $ 15,421 $ 14,275 Effect of stock-based compensation expense by line item: Research and development $ 3,301 $ 2,860 $ 6,488 $ 5,497 General and administrative 4,643 5,319 8,933 8,778 Total stock-based compensation expense included in net loss $ 7,944 $ 8,179 $ 15,421 $ 14,275 Unrecognized

Commitments and Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2022
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	9. Commitments and Contingencies The Company has a Research, Development and Commercialization Agreement with Hoffmann-La The agreement requires future milestone payments to Roche. Remaining milestones under the agreement total $8 million and are payable upon Madrigal achieving specified objectives related to future regulatory approval in the United States and Europe of resmetirom or a product developed from resmetirom. Furthermore, a tiered single-digit royalty is payable on net sales of resmetirom or a product developed from resmetirom, subject to certain reductions. The Company has not achieved any additional product development or regulatory milestones and had no Licensed Product sales for the six months ended June 30, 2022 and 2021. The Company has entered into customary contractual arrangements and letters of intent in preparation for and in support of the Phase 3 clinical trials.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Principle of Consolidation	Principle of Consolidation The consolidated financial statements include the financial statements of the Company and its wholly owned subsidiaries. All significant intercompany balances have been eliminated in consolidation.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities, and the reported amounts of revenues and expenses during the reporting periods. The Company bases its estimates on historical experience and various other assumptions that management believes to be reasonable under the circumstances. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.
Cash and Cash Equivalents	Cash and Cash Equivalents The Company considers all highly liquid investments with original maturities of three months or less at the date of purchase to be cash equivalents. The Company maintains its cash in bank accounts, the balance of which, at times, exceeds Federal Deposit Insurance Corporation insured limits. The primary objective of the Company’s investment activities is to preserve its capital for the purpose of funding operations and the Company does not enter into investments for trading or speculative purposes. The Company’s cash is deposited in highly rated financial institutions in the United States. The Company invests in money market funds and high-grade, commercial paper and corporate bonds, which management believes are subject to minimal credit and market risk.
Marketable Securities	Marketable Securities Marketable securities consist of investments in high-grade corporate obligations and government and government agency obligations that are classified as available-for-sale. The Company adjusts the cost of available-for-sale available-for-sale Marketable securities are stated at fair value, including accrued interest, with their unrealized gains and losses included as a component of accumulated other comprehensive income or loss, which is a separate component of stockholders’ equity. The fair value of these securities is based on quoted prices and observable inputs on a recurring basis. Realized gains and losses are determined on the specific identification method. During the six months ended June 30, 2022 and 2021, the Company did not have any realized gains or losses on marketable securities.
Fair Value of Financial Instruments	Fair Value of Financial Instruments The carrying amounts of the Company’s financial instruments, which include cash equivalents and marketable securities, approximate their fair values. The fair value of the Company’s financial instruments reflects the amounts that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy has the following three levels: Level 1—quoted prices in active markets for identical assets and liabilities. Level 2—observable inputs other than Level 1 inputs. Examples of Level 2 inputs include quoted prices in active markets for similar assets or liabilities and quoted prices for identical assets or liabilities in markets that are not active. Level 3—unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Financial assets and liabilities are classified in their entirety within the fair value hierarchy based on the lowest level of input that is significant to the fair value measurement. The Company measures the fair value of its marketable securities by taking into consideration valuations obtained from third- party pricing sources. The pricing services utilize industry standard valuation models, including both income and market based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker-dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities and other observable inputs. As of June 30, 2022, the Company’s financial assets valued based on Level 1 inputs consisted of cash and cash equivalents in a money market fund, its financial assets valued based on Level 2 inputs consisted of high-grade corporate and government agency bonds and commercial paper, and it had no financial assets valued based on Level 3 inputs. During the six months ended June 30, 2022 and 2021, the Company did not have any transfers of financial assets between Levels 1 and 2. As of June 30, 2022 and December 31, 2021, the Company did not have any financial liabilities that were recorded at fair value on a recurring basis on the balance sheet.
Research and Development Costs	Research and Development Costs Research and development costs are expensed as incurred. Research and development costs are comprised of costs incurred in performing research and development activities, including internal costs (including stock-based compensation), costs for consultants, milestone payments under licensing agreements, and other costs associated with the Company’s preclinical and clinical programs. In particular, the Company has conducted safety studies in animals, optimized and implemented the manufacturing of our drug, and conducted Phase 1-3
Patents	Patents Costs to secure and defend patents are expensed as incurred and are classified as general and administrative expense in the Company’s consolidated statements of operations.
Stock-Based Compensation	Stock-Based Compensation The Company recognizes stock-based compensation expense based on the grant date fair value of stock options granted to employees, officers, and directors. The Company uses the Black-Scholes option pricing model to determine the grant date fair value as management believes it is the most appropriate valuation method for its option grants. The Black-Scholes model requires inputs for risk-free interest rate, dividend yield, volatility and expected lives of the options. The expected lives for options granted represent the period of time that options granted are expected to be outstanding. The Company uses the simplified method for determining the expected lives of options. Expected volatility is based upon an industry estimate or blended rate including the Company’s historical trading activity. The risk-free rate for periods within the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of the grant. The Company estimates the forfeiture rate based on historical data. This analysis is re-evaluated Certain of the employee stock options granted by the Company are structured to qualify as incentive stock options (“ISOs”). Under current tax regulations, the Company does not receive a tax deduction for the issuance, exercise or disposition of ISOs if the employee meets certain holding requirements. If the employee does not meet the holding requirements, a disqualifying disposition occurs, at which time the Company may receive a tax deduction. The Company does not record tax benefits related to ISOs unless and until a disqualifying disposition is reported. In the event of a disqualifying disposition, the entire tax benefit is recorded as a reduction of income tax expense. The Company has not recognized any income tax benefit for its share-based compensation arrangements due to the fact that the Company does not believe it is more likely than not it will realize the related deferred tax assets.
Income Taxes	Income Taxes The Company uses the asset and liability method to account for income taxes. Deferred tax assets and liabilities are determined based on the expected future tax consequences of temporary differences between the Company’s financial statement carrying amounts and the tax basis of assets and liabilities using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. The Company currently maintains a 100% valuation allowance on its deferred tax assets.
Comprehensive Loss	Comprehensive Loss Comprehensive loss is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner
Basic and Diluted Loss Per Common Share	Basic and Diluted Loss Per Common Share Basic net loss per share is computed using the weighted average number of common shares outstanding during the period, excluding any restricted stock that has been issued but is not yet vested. Diluted net loss per common share is computed using the weighted average number of common shares outstanding and the weighted average dilutive potential common shares outstanding using the treasury stock method. However, for the six months ended June 30, 2022 and 2021, diluted net loss per share is the same as basic net loss per share because the inclusion of weighted average shares of unvested restricted common stock, common stock issuable upon the exercise of stock options, and common stock issuable upon the conversion of preferred stock would be anti-dilutive. The following table summarizes outstanding securities not included in the computation of diluted net loss per common share, as their inclusion would be anti-dilutive: Six Months Ended June 30, 2022 2021 Common stock options 2,976,545 2,268,787 Preferred stock 1,969,797 1,969,797 Warrants 14,899 —
Recent Accounting Pronouncements	Recent Accounting Pronouncements None

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Summary of the outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive	The following table summarizes outstanding securities not included in the computation of diluted net loss per common share, as their inclusion would be anti-dilutive: Six Months Ended June 30, 2022 2021 Common stock options 2,976,545 2,268,787 Preferred stock 1,969,797 1,969,797 Warrants 14,899 —

Cash, Cash Equivalents and Ma_2

Cash, Cash Equivalents and Marketable Securities (Tables)	6 Months Ended
	Jun. 30, 2022
Cash and Cash Equivalents [Abstract]
Summary of cash, cash equivalents and available-for-sale marketable securities	A summary of cash, cash equivalents and available-for-sale June 30, 2022 Unrealized Unrealized Fair Cost gains losses Value Cash and cash equivalents: Cash (Level 1) $ 1,728 $ — $ — $ 1,728 Money market funds (Level 1) 37,809 — — 37,809 Corporate debt securities due within 3 months of date of purchase (Level 2) 13,735 — — 13,735 Total cash and cash equivalents 53,272 — — 53,272 Marketable securities: Corporate debt securities due within 1 year of date of purchase (Level 2) 152,923 1 (431 ) 152,493 U.S. government and government sponsored entities due within 1 year of date of purchase (Level 2) 6,018 — (17 ) 6,001 Total cash, cash equivalents and marketable securities $ 212,213 $ 1 $ (448 ) $ 211,766 December 31, 2021 Unrealized Unrealized Fair Cost gains losses Value Cash and cash equivalents: Cash (Level 1) $ 18,877 $ — $ — $ 18,877 Money market funds (Level 1) 17,392 — — 17,392 Total cash and cash equivalents 36,269 — — 36,269 Marketable securities: Corporate debt securities due within 1 year of date of purchase (Level 2) 228,348 6 (66 ) 228,288 Corporate debt securities due within 1 to 2 years of date of purchase (Level 2) 5,809 — (20 ) 5,789 Total cash, cash equivalents and marketable securities $ 270,426 $ 6 $ (86 ) $ 270,346

Accrued Liabilities (Tables)

Accrued Liabilities (Tables)	6 Months Ended
	Jun. 30, 2022
Accrued Liabilities, Current [Abstract]
Schedule of Accrued Liabilities	Accrued liabilities as of June 30, 2022 and December 31, 2021 consisted of the following (in thousands): June 30, December 31, 2022 2021 Contract research organization costs $ 57,288 $ 38,349 Other clinical study related costs 4,369 3,957 Compensation and benefits 3,577 6,769 Professional fees 3,959 2,455 Other 2,643 3,518 Total accrued liabilities $ 71,836 $ 55,048

Long Term Debt - (Tables)

Long Term Debt - (Tables)	6 Months Ended
	Jun. 30, 2022
Debt Disclosure [Abstract]
Schedule of Maturities of Long-Term Debt [Table Text Block]	Future minimum payments, including interest and principal, under the loans payable outstanding as of June 30, 2022 are as follows (in thousands): Period Ending June 30, 2022: Amount 2022 (remaining six months) $ 2,196 2023 4,410 2024 9,338 Thereafter 50,782 $ 66,726 Less amount representing interest (14,051 ) Less unamortized discount (4,005 ) Loans payable, net of discount $ 48,670

Stock-based Compensation (Table

Stock-based Compensation (Tables)	6 Months Ended
	Jun. 30, 2022
Share-based Payment Arrangement [Abstract]
Summary of stock option activity	The following table summarizes stock option activity during the six months ended June 30, 2022: Shares Weighted Outstanding at January 1, 2022 2,301,574 $ 78.90 Options granted 736,395 83.35 Options cancelled (61,424 ) 100.82 Outstanding at June 30, 2022 2,976,545 $ 79.54 Exercisable at June 30, 2022 1,669,315 $ 69.41
Schedule of stock-based compensation expense	Stock-based compensation expense during the six months ended June 30, 2022 and 2021 was as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Stock-based compensation expense by type of award: Stock options $ 7,944 $ 8,179 $ 15,421 $ 14,275 Total stock-based compensation expense $ 7,944 $ 8,179 $ 15,421 $ 14,275 Effect of stock-based compensation expense by line item: Research and development $ 3,301 $ 2,860 $ 6,488 $ 5,497 General and administrative 4,643 5,319 8,933 8,778 Total stock-based compensation expense included in net loss $ 7,944 $ 8,179 $ 15,421 $ 14,275

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Income Taxes (Details)	6 Months Ended
	Jun. 30, 2022
Income Taxes
Valuation allowance on deferred tax assets (as a percent)	100%

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Basic and Diluted Loss Per Common Share (Details) - shares	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Stock options
Anti-dilutive securities
Outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive (in shares)	2,976,545	2,268,787
Preferred Stock
Anti-dilutive securities
Outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive (in shares)	1,969,797	1,969,797
Warrants
Anti-dilutive securities
Outstanding securities not included in the computation of diluted net loss per common share as their inclusion would be anti-dilutive (in shares)	14,899	0

Liquidity and Uncertainties (De

Liquidity and Uncertainties (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended				6 Months Ended
	May 31, 2022	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Net loss		$ (70,730)	$ (57,518)	$ (61,651)	$ (52,546)	$ (128,248)	$ (114,197)
Accumulated deficit		(795,558)				(795,558)		$ (667,310)
Debt instrument, Face amount		$ 50,000				$ 50,000
Term Loan [Member]
Debt instrument, Face amount	$ 250,000
Proceeds from issuance of debt	$ 50,000

Cash, Cash Equivalents and Ma_3

Cash, Cash Equivalents and Marketable Securities (Details) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Cash, Cash Equivalents and Marketable Securities
Total cash, cash equivalents and marketable securities, Unrealized gains	$ 1	$ 6
Total cash, cash equivalents and marketable securities, Unrealized losses	(448)	(86)
Carrying value
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	53,272	36,269
Total cash, cash equivalents and marketable securities, Cost	212,213	270,426
Fair value
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	53,272	36,269
Total cash, cash equivalents and marketable securities, Fair value	$ 211,766	$ 270,346
Corporate debt securities due within 3 months of date of purchase
Cash, Cash Equivalents and Marketable Securities
Maturity period from date of purchase to classify an investment as marketable securities	3 months
Corporate debt securities due within 3 months of date of purchase | Carrying value | Level 2
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	$ 13,735
Corporate debt securities due within 1 year of date of purchase
Cash, Cash Equivalents and Marketable Securities
Maturity period from date of purchase to classify an investment as marketable securities	1 year	1 year
Corporate debt securities due within 1 year of date of purchase | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, unrealized gains	$ 1	$ 6
Marketable securities, unrealized losses	(431)	(66)
Corporate debt securities due within 1 year of date of purchase | Carrying value | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, cost	152,923	228,348
Corporate debt securities due within 1 year of date of purchase | Fair value | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, fair value	$ 152,493	$ 228,288
Corporate debt securities due within 1 to 2 years of date of purchase | Maximum [Member]
Cash, Cash Equivalents and Marketable Securities
Maturity period from date of purchase to classify an investment as marketable securities		2 years
Corporate debt securities due within 1 to 2 years of date of purchase | Minimum [Member]
Cash, Cash Equivalents and Marketable Securities
Maturity period from date of purchase to classify an investment as marketable securities		1 year
Corporate debt securities due within 1 to 2 years of date of purchase | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, unrealized gains		$ 0
Marketable securities, unrealized losses		(20)
Corporate debt securities due within 1 to 2 years of date of purchase | Carrying value | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, cost		5,809
Corporate debt securities due within 1 to 2 years of date of purchase | Fair value | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, fair value		5,789
U.S. government and government sponsored entities due within 1 year of date of purchase
Cash, Cash Equivalents and Marketable Securities
Maturity period from date of purchase to classify an investment as marketable securities	1 year
U.S. government and government sponsored entities due within 1 year of date of purchase | Carrying value | Level 2
Cash, Cash Equivalents and Marketable Securities
Marketable securities, cost	$ 6,018
Marketable securities, unrealized losses	(17)
Marketable securities, fair value	6,001
Cash | Carrying value | Level 1
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	1,728	18,877
Cash | Fair value | Level 1
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	1,728	18,877
Money market funds | Carrying value | Level 1
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	37,809	17,392
Money market funds | Fair value | Level 1
Cash, Cash Equivalents and Marketable Securities
Cash and cash equivalents	$ 37,809	$ 17,392

Accrued Liabilities (Details)

Accrued Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accrued Liabilities, Current [Abstract]
Contract research organization costs	$ 57,288	$ 38,349
Other clinical study related costs	4,369	3,957
Compensation and benefits	3,577	6,769
Professional fees	3,959	2,455
Other	2,643	3,518
Total accrued liabilities	$ 71,836	$ 55,048

Long Term Debt - Schedule of Ma

Long Term Debt - Schedule of Maturities of Long-Term Debt (Detail) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Long-Term Debt, Fiscal Year Maturity [Abstract]
2022 (remaining six months)	$ 2,196
2023	4,410
2024	9,338
Thereafter	50,782
Long-Term Debt	66,726
Less amount representing interest	(14,051)
Less unamortized discount	(4,005)
Loan payable, net of discount	$ 48,670

Long Term Debt - Additional Inf

Long Term Debt - Additional Information (Detail) - USD ($) $ in Millions				1 Months Ended
	Jan. 01, 2023	May 09, 2022	May 01, 2022	May 31, 2022	Jun. 30, 2022
Debt instrument, Face amount					$ 50
Interest rate					8.70%
Percenatge of Term charges on aggregate principal amount				5.35%
Debt conversion, converted instrument, warrants or options issued			14,899
Debt conversion, converted instrument, amount		$ 0.6
Loan Facility [Member] | Subsequent Event [Member]
Line of credit facility, maximum borrowing capacity	$ 35
Line of credit facility, expiration date	Sep. 30, 2024
Drawn In Two Separate Tranches Upon AchievementOf Resmetirom Clinical And Regulatory Milestone s [Member]
Unused borrowing capacity that can be drawn				$ 125
Term Loan
Debt instrument, Face amount				250
Proceeds from issuance of debt				$ 50
Long term debt floor interest rate percentage				7.45%
Debt Instrument Interest Payments Terms				The Company will pay interest-only monthly payments of accrued interest under the Loan Facility for a period of 30 months, which period may be extended to 36, 48, and 60 months upon the successive achievement of certain clinical and regulatory milestones
Term Loan | Drawn In Two Separate Tranches Upon AchievementOf Resmetirom Clinical And Regulatory Milestone s [Member]
Unused borrowing capacity that can be drawn				$ 75

Stockholders' Equity (Deficit)

Stockholders' Equity (Deficit) - Common Stock (Details)	6 Months Ended
	Jun. 30, 2022 Vote
Stockholders' Equity Note [Abstract]
Number of votes per share that common stockholders are entitled to receive	1

Stockholders' Equity (Deficit_2

Stockholders' Equity (Deficit) - Preferred Stock (Details) - Series A Convertible Preferred Stock	1 Months Ended
	Jun. 30, 2017 Vote shares
Stockholders' Equity (Deficit)
Preferred stock conversion ratio | shares	1
Preferred shares number voting rights | Vote	0

Stockholders' Equity (Deficit_3

Stockholders' Equity (Deficit) - At The Market Issuances (Details) - USD ($) $ in Millions	1 Months Ended	6 Months Ended
	Nov. 30, 2020	Jun. 30, 2022	Jun. 30, 2021
Stockholders' Equity (Deficit)
Number of shares sold by the entity			1,087,126
At-The-Market Issuance Sales Agreement
Stockholders' Equity (Deficit)
Number of shares sold by the entity		1,126,733
Value of shares sold by the entity		$ 137.4
Net proceeds after deducting commissions and other transactions costs		$ 134.8
At-The-Market Issuance Sales Agreement | 2021 Sales Agreement [Member]
Stockholders' Equity (Deficit)
Number of shares sold by the entity		497,043
Value of shares sold by the entity		$ 40.8
Net proceeds after deducting commissions and other transactions costs		39.8
Remaining reserved amount under shelf registration		159.2
Cowen & Co. LLC | Maximum | At-The-Market Issuance Sales Agreement
Stockholders' Equity (Deficit)
Maximum aggregate offering price	$ 200	$ 200

Stock-based Compensation - Stoc

Stock-based Compensation - Stock Option (Details) - USD ($) $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Additional disclosures
Proceeds resulting from exercise of stock options	$ 0	$ 478
Maximum
Stock-based compensation expense
Expiration period	10 years
Stock options
Stock-based compensation expense
Options outstanding to purchase of common stock	2,976,545
Shares available for future issuance	986,322
Shares
Outstanding at the beginning of the year (in shares)	2,301,574
Options granted (in shares)	736,395
Options cancelled (in shares)	(61,424)
Outstanding at the end of the year (in shares)	2,976,545
Exercisable at the end of the year (in shares)	1,669,315
Weighted average exercise price
Outstanding at the beginning of the year (in dollars per share)	$ 78.9
Options granted (in dollars per share)	83.35
Options cancelled (in dollars per share)	100.82
Outstanding at the end of the year (in dollars per share)	79.54
Exercisable at the end of the year (in dollars per share)	$ 69.41
Additional disclosures
Total intrinsic value of options exercised	$ 0	100
Proceeds resulting from exercise of stock options	$ 0	$ 500
Weighted-average grant date fair value of options (in dollars per share)	$ 55.84	$ 78.34

Stock-based Compensation - Expe

Stock-based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Stock-based compensation expense
Stock-based compensation expense	$ 7,944	$ 8,179	$ 15,421	$ 14,275
Research and development
Stock-based compensation expense
Stock-based compensation expense	3,301	2,860	6,488	5,497
General and administrative
Stock-based compensation expense
Stock-based compensation expense	4,643	5,319	8,933	8,778
Stock options
Stock-based compensation expense
Stock-based compensation expense	$ 7,944	$ 8,179	$ 15,421	$ 14,275

Stock-based Compensation - Unre

Stock-based Compensation - Unrecognized Expense (Details) - Stock options $ in Millions	6 Months Ended
	Jun. 30, 2022 USD ($)
Unrecognized stock-based compensation expense
Unrecognized stock compensation expense	$ 70
Weighted average remaining period (in years)	2 years 11 months 12 days

Commitments and Contingencies (

Commitments and Contingencies (Details) - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2019
Commitments and Contingencies
Licensed product sales	$ 0	$ 0
Research, Development and Commercialization Agreement | Hoffmann-La Roche ("Roche")
Commitments and Contingencies
Remainder of future milestone payments			$ 8