Affymax (AFFY) 10-K 2012 FY Annual report

Exhibit 32.1

CERTIFICATION

Pursuant to the requirement set forth in Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and Section 1350 of Chapter 63 of Title 18 of the United States Code (18 U.S.C. § 1350), John A. Orwin, Chief Executive Officer and Director, and Herb Cross, Chief Financial Officer, of Affymax, Inc. (the “Company”), each hereby certifies that to the best of his knowledge:

1. The Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2012, to which this certification is attached as Exhibit 32.1 (the “Annual Report”), fully complies with the requirements of Section 13(a) or 15(d) of the Exchange Act, and

2. The information contained in this Annual Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

		By:	/s/ JOHN A. ORWIN
			Chief Executive Officer and Director (Principal Executive Officer)
		By:	/s/ HERB CROSS
			Chief Financial Officer
Date:	April 1, 2013		(Principal Financial Officer)

This certification accompanies the Form 10-K to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of Affymax, Inc. under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before or after the date of the Form 10-K), irrespective of any general incorporation language contained in such filing.