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Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in the registration statements of Mast Therapeutics, Inc. on Form S-8 (Nos. 333-174940, 333-151903, 333-126551 and 333-190376) and the registration statements on Form S-3 (Nos. 333-179989, 333-174203, 333-165691, 333-164177, 333-159376, 333-133824, 333-127857 and 333-117022) of our report dated March 26, 2014 relating to the financial statements, which appears in this Form10-K.
/s/ PricewaterhouseCoopers LLP
San Diego, California
March 26, 2014