| Document and Entity Information | Mar. 29, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Mar. 29, 2022 |
| Entity Registrant Name | HTG Molecular Diagnostics, Inc. |
| Entity Central Index Key | 0001169987 |
| Entity Emerging Growth Company | false |
| Entity File Number | 001-37369 |
| Entity Tax Identification Number | 86-0912294 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 3430 E. Global Loop |
| Entity Address, City or Town | Tucson |
| Entity Address, State or Province | AZ |
| Entity Address, Postal Zip Code | 85706 |
| City Area Code | 877 |
| Local Phone Number | 289-2615 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Security 12b Title | Common Stock, $0.001 par value per share |
| Trading Symbol | HTGM |
| Security Exchange Name | NASDAQ |
