Cytosorbents (CTSO) 10-K 2011 FY Annual report

 Exhibit 32.1

CERTIFICATION OF

CHIEF EXECUTIVE OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350

In connection with the accompanying quarterly report on Form 10-K of Cytosorbents Corporation for the annual ending December 31, 2011, I, Phillip Chan, President and Chief Executive Officer of Cytosorbents Corporation, hereby certify pursuant to 18 U.S.C. Section 1350, as adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge and belief, that:

1.	Such annual report of Form 10-K for the year ending December 31, 2011, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2.	The information contained in such annual report of Form 10-K for the year ending December 31, 2011, fairly represents in all material respects, the financial condition and results of operations of Cytosorbents Corporation

Date: March 30, 2012

CYTOSORBENTS CORPORATION

By:/s/ Phillip Chan

Phillip Chan

Chief Executive Officer