YM Biosciences 6-K Current report (foreign)

EXHIBIT 99.1

FORM 51-102F3

MATERIAL CHANGE REPORT

ITEM 1 Name and Address of Company:

YM BioSciences Inc. (the “Company” or “YM”)

5045 Orbitor Drive

Building 11, Suite 400

Mississauga, Ontario L4W 4Y4

ITEM 2 Date of Material Change:

October 14, 2010

ITEM 3 News Release:

A news release disclosing the information was issued by the Company on October 14, 2010 by Canada Newswire.

ITEM 4 Summary of Material Change:

The Company announced that it has appointed Dr. Nick Glover as Chief Executive Officer to be effective at the Company’s Annual General Meeting on November 18, 2010.

ITEM 5 Full Description of Material Change:

Please see the press release attached hereto as Schedule “A”.

ITEM 6 Reliance on subsection 7.1(2) of National Instrument 51-102

N/A

ITEM 7 Omitted Information:

N/A

ITEM 8 Executive Officer:

David G.P. Allan

Chairman, Chief Executive Officer

Telephone: (905) 629-9761

ITEM 9 Date of Report:

October 22, 2010

Schedule “A”