Exhibit 31.1
CERTIFICATION
I, John M. Maraganore, Ph.D., certify that:
| 1) | I have reviewed this Amendment No. 1 to Quarterly Report on Form 10-Q/A of Alnylam Pharmaceuticals, Inc.; and |
| 2) | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report. |
| Date: January 9, 2015 | /s/ John M. Maraganore | |||
| John M. Maraganore, Ph.D. | ||||
| Chief Executive Officer |
