Amicus Therapeutics (FOLD) 8-K Amicus Therapeutics Announces Additional Positive Data in Pompe Disease Phase 1/2 Study at World Muscle Society

Exhibit 99.2

Positive Pompe Phase 1/2 Data at World Muscle Society Conference Call & Webcast October 4, 2017

Safe Harbor This presentation contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to encouraging preliminary data from a global Phase 1/2 study to investigate ATB200/AT2221 for the treatment of Pompe and the potential implications on these data for the future advancement and development of ATB200/AT2221. Words such as, but not limited to, “look forward to,” “believe,” “expect,” “anticipate,” “estimate,” “intend,” "confidence," "encouraged," “potential,” “plan,” “targets,” “likely,” “may,” “will,” “would,” “should” and “could,” and similar expressions or words identify forward-looking statements. The forward looking statements included in this presentation are based on management's current expectations and beliefs which are subject to a number of risks, uncertainties and factors, including that the preliminary data based on a small patient sample and reported before completion of the study will not be predictive of future results, that results of additional preliminary data or data from the completed study or any future study will not yield results that are consistent with the preliminary data presented, that the Company will not be able to demonstrate the safety and efficacy of ATB200/AT2221, that later study results will not support further development, or even if such later results are favorable, that the Company will not be able to successfully complete the development of, obtain regulatory approval for, or successfully commercialize ATB200/AT2221. In addition, all forward looking statements are subject to the other risks and uncertainties detailed in our Annual Report on Form 10-K for the year ended December 31, 2016 and Quarterly Report on 10-Q for the Quarter ended June 30, 2017. As a consequence, actual results may differ materially from those set forth in this press release. You are cautioned not to place undue reliance on these forward looking statements, which speak only of the date hereof. All forward looking statements are qualified in their entirety by this cautionary statement and we undertake no obligation to revise this press release to reflect events or circumstances after the date hereof. Introduction

Novel Pompe Treatment Paradigm with Three Key Differentiators Novel ERT for Pompe Disease – ATB200 + Chaperone Chaperone addition Optimized mixture of glycans ATB200 + Chaperone: A Highly Differentiated Approach ATB200 (Novel ERT) High levels of M6P and bis M6P *Artist rendering, not actual product image

Phase 1/2 ATB200-02 Study Design Pompe Phase 1/2 Study ATB200-02 Data at WMS Phase 1/2 Clinical Study to Evaluate Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ATB200 + Chaperone (ATB200/AT2221) at 16 Sites in 5 Countries 18-Week Primary Treatment Period with Long-Term Extension (n=20) ATB200 5mg/kg (wk 2) 10mg/kg (wk 4) 20mg/kg (wk 6) ATB200 20mg/kg + AT2221 (Low Dose) wks 8,10,12 ATB200 20mg/kg + AT2221 (High Dose) wk 14+ Cohort 1 (Ambulatory ERT-Switch, n=11) Cohort 2 (Non-Ambulatory ERT-Switch, n=4) & Cohort 3 (ERT-Naïve, n=5) ATB200 20mg/kg + AT2221 (High Dose) wk 2+ Safety/Tolerability Plasma PK Infusion-Associated Reactions Antibody & Cytokine Levels Pharmacodynamics Efficacy (Long-Term Extension) Assessments:

Baseline Characteristics (N=20) Cohort 1: Ambulatory ERT-Switch* (N=11) Cohort 2: Non-Ambulatory ERT-Switch (N=4) Cohort 3: ERT-Naïve (N=5) Time on Standard of Care – mean years (SD) 4.77 (1.4)* 8.9 (3.8) N/A Age – mean years (range) 49.4 (28, 66) 36.0 (18, 56) 49.4 (24, 65) Sex M:F 9:2 3:1 1:4 6MWT – mean meters (SD) 392.0 (93.4) N/A 399.5 (83.5) FVC Upright – mean % predicted (SD) 52.3 (13.2) N/A 53.4 (20.3) Baseline Characteristics Patients Across Three Cohorts Representative of Overall Late-Onset Pompe Population with Impairment at Baseline Pompe Phase 1/2 Study ATB200-02 Data at WMS Baseline Characteristics of Patients in Phase 1/2 ATB200-02 Study (n=20) *Cohort 1 patients required to have been on ERT Standard of Care for 2-6 years at baseline

Summary of Available Data Pompe Phase 1/2 Study ATB200-02 Data at WMS *One patient discontinued after completing Stage 1 (week 18) due to travel burden/family considerations and one patient’s month 6 assessments pending due to an incomplete visit Cohort 1 (ERT-Switch, n=11) Cohort 2 (Non-ambulatory ERT-Switch, n=4) Cohort 3 (ERT-Naive, n=5) Safety and tolerability n=11 n=4 n=5 Biomarkers n=11 n=4 n=5 Functional assessments at month Month 6 (n=9)* Month 9 (n=8) Month 6 (n=4) Month 6 (n=5) Month 9 (n=2) Functional assessments 6MWT Other motor function tests Pulmonary function (FVC, MIP/MEP) Muscle Strength Tests 6MWT Other motor function tests Pulmonary function (FVC, MIP/MEP)

Safety Summary (n=20)* AEs were generally mild and transient Very low number (<1%) of infusion-associated reactions (IARs) after 400+ total infusions One IAR event in one ERT-switch patient (skin discoloration) Two IAR events in one ERT-naïve patient (localized pruritus, erythema and burning sensation) Longest duration of treatment is 72 weeks AEs Generally Mild and Transient with Very Low (<1%) Rate of Infusion-Associated Reactions After 400+ Total Infusions of ATB200/AT2221 Across All Cohorts Pompe Phase 1/2 Study ATB200-02 Data at WMS *Reported through interim data analysis (maximum 72 weeks)

Persistent and Durable Improvement in Biomarkers of Muscle Damage (CK, ALT, AST) and Disease Substrate (Hex4) for up to 58 Weeks on ATB200/AT2221 Pompe Phase 1/2 Study ATB200-02 Data at WMS Cohort 1 (ERT-Switch): Biomarkers up to Week 58 (N=11)* *Reported through interim data analysis (maximum 58 weeks); Missing values either unable to be analyzed or not yet analyzed Mean Percent Change From Baseline (Mean ± SE) ATB200 dose escalation (5>10>20) ATB200 20 mg/kg + low dose AT2221 ATB200 20 mg/kg + high dose AT2221 Visit BL WK 2 WK 4 WK 6 WK 8 WK 10 WK 12 WK 14 WK 16 WK 18 WK 34 WK 46 WK 58 N 11 11 10 9-10 11 11 8-11 11 11 11 9 8 3 Mean Percent Change From Baseline (Mean ± SE) ATB200 dose escalation (5>10>20) ATB200 20 mg/kg + low dose AT2221 ATB200 20 mg/kg + high dose AT2221 Visit BL WK 2 WK 4 WK 6 WK 8 WK 10 WK 12 WK 14 WK 16 WK 18 WK 34 WK 46 WK 58 N 11 11 10 9-10 11 11 8-11 11 11 11 9 8 3 Muscle Damage Biomarkers (% Change from Baseline for CK, ALT, and AST) Disease Substrate Biomarker (% Change from Baseline for Hex 4)

Improvement in Biomarkers of Muscle Damage (CK) and Disease Substrate for up to 24 Weeks on ATB200/AT2221 Pompe Phase 1/2 Study ATB200-02 Data at WMS Cohort 2 (Non-Ambulatory ERT-Switch): Biomarkers up to Week 24 (N=4)* *Reported through interim data analysis (maximum 24 weeks); Missing values either unable to be analyzed or not yet analyzed Muscle Damage Biomarkers (% Change from Baseline for CK, ALT, and AST) Disease Substrate Biomarker (% Change from Baseline for Hex 4) Mean Percent Change From Baseline (Mean ± SE) ATB200 20 mg/kg + high dose AT2221 Visit BL WK 2 WK 4 WK 12 WK 24 N 4 4 4 3 4 ATB200 20 mg/kg + high dose AT2221 Mean Percent Change From Baseline (Mean ± SE) Visit BL WK 2 WK 4 WK 12 WK 24 N 4 4 4 3 4

Cohort 3 (ERT-Naïve): Biomarkers up to Week 36 (N=6)* Improvement in Biomarkers of Muscle Damage and Disease Substrate for up to 36 Weeks on ATB200/AT2221 Pompe Phase 1/2 Study ATB200-02 Data at WMS *Reported through interim data analysis (maximum 36 weeks); Missing values either unable to be analyzed or not yet analyzed Mean Percent Change From Baseline (Mean ± SE) Mean Percent Change From Baseline (Mean ± SE) ATB200 20 mg/kg + high dose AT2221 ATB200 20 mg/kg + high dose AT2221 Visit BL WK 2 WK 4 WK 12 WK 24 WK 36 N 5 5 4-5 5 5 2 Visit BL WK 2 WK 4 WK 12 WK 24 WK 36 N 5 5 4-5 5 5 2 Muscle Damage Biomarkers (% Change from Baseline for CK, ALT, and AST) Disease Substrate Biomarker (% Change from Baseline for Hex 4)

Cohort 1 and 3: 6-Minute Walk Test (6MWT) (n=14) Pompe Phase 1/2 Study ATB200-02 Data at WMS Mean 6MWT Distance Improved for Both ERT-Naïve Patients (+41.8 Meters) and ERT-Switch Patients (+35.3 Meters) at Month 6 with Continued Benefit Out to Month 9 6-Minute Walk Test (m): Month 6 and 9 6MWT distance increased in 7/9 and 8/8 ERT-switch patients at Month 6 and 9, respectively Two patients stable at Month 6, one of these patients reached Month 9 and had increased walking distance 6MWT Increased in 5/5 and 2/2 ERT-Naïve Patients at Month 6 and Month 9, Respectively Cohort Baseline (n=10) Mean (SD) Change at Month 6 (n=9) Mean (SD) Change at Month 9 (n=8) Mean (SD) Cohort 1 ERT-Switch 397.2 (96.8) +35.3 (40.1) +37.2 (33.8) Cohort Baseline (n=5) Mean (SD) Change at Month 6 (n=5) Mean (SD) Change at Month 9 (n=2) Mean (SD) Cohort 3 ERT-Naïve 399.5 (83.5) +41.8 (29.4) +74.9 (4.0)

Cohort 1 and 3: Other Motor Function Tests (n=14) Pompe Phase 1/2 Study ATB200-02 Data at WMS Improvement in Nearly All Motor Function Tests with 6MWT Consistent with Overall Improvement in Motor Performance for Both ERT-Switch and ERT-Naïve Patients at Month 6 and 9 Other Motor Function Tests: Month 6 and 9 Notes: * Median change from baseline was -0.8 and 4/5 had decrease; # N=9 Missing values not obtained due to patient refusal to perform test Cohort Assessment (sec) Baseline (n=10) Mean (SD) Change at Month 6 (n=9) Mean (SD) Change at Month 9 (n=8) Mean (SD) Cohort 1: ERT-Switch Timed up and Go 10.5 (6.6) -2.2 (3.4) -0.6 (2.5) 4 Stair Climb 4.1 (2.7) -1.0 (1.2) -0.9 (1.3) 10M walk 7.4 (3.0) -0.3 (1.6) 0.1 (1.3) Gowers# 7.9 (2.8) -2.2 (2.0) -2.1 (1.3) GSGC Score 12.6 (4.8) -0.8 (3.0) -0.9 (3.5) Cohort Assessment (sec) Baseline (n=5) Mean (SD) Change at Month 6 (n=5) Mean (SD) Change at Month 9 (n=2) Mean (SD) Cohort 3: ERT-Naïve Timed up and Go 9.4 (2.9) -1.0 (1.1) -1.6 (1.0) 4 Stair Climb 4.2 (1.5) -0.6 (0.3) -0.8 (0.3) 10M walk 7.9 (3.0) -0.7 (1.1) -1.0 (0.1) Gowers 13.9 (11.0) 7.9* (21.0) -1.3 (0.0) GSGC Score 12.2 (3.6) -1.8 (3.8) -4.0 (1.4)

Cohort 2: Muscle Strength Testing at Month 6 (n=4) Pompe Phase 1/2 Study ATB200-02 Data at WMS Substantial and Consistent Improvement in Upper Extremity Strength in Non-Ambulatory ERT-Switch Patients in Nearly All Quantitative and Qualitative Measures at Month 6 Assessment Muscle Group Tested Baseline Change to Month 6 Left Mean (SD) Right Mean (SD) Left Mean (SD) Right Mean (SD) QMT- Quantitative Muscle Testing - Dynamometer (pounds force) Shoulder Adduction* 4.2 (6.8) 1.5 (1.9) +2.3 (4.4) +5.8 (8.4) Shoulder Abduction 9.8 (10.9) 6.9 (7.6) +0.3 (5.1) +0.8 (1.5) Elbow Flex 7.8 (8.7) 4.9 (5.1) -0.1 (10.0) +2.4 (6.1) Elbow Extension 7.3 (8.1) 5.0 (5.9) +1.5 (3.4) +4.1 (2.1) MMT - Manual Muscle Testing (manual score) Shoulder Adduction* 1.3 (1.2) 1.0 (1.0) +0.7 (1.2) +0.7 (1.2) Shoulder Abduction** 1.3 (1.2) 1.3 (1.2) +0.5 (0.7) 0.0 (0.0) Elbow Flex 2.3 (2.5) 2.0 (2.0) +0.7 (0.6) +1.0 (1.0) Elbow Extension 2.0 (2.0) 2.0 (2.0) +0.7 (0.6) +1.0 (1.0) Note: MMT Scoring: 1) Visible muscle movement, but no movement at the joint, 2) Movement at the joint, but not against gravity, 3) Movement against gravity, but not against added resistance, 4) Movement against resistance, but less than normal, 5) Normal strength *N=3 or **N=2 due to assessment not being performed at some visits for some patients

Forced Vital Capacity (FVC) Summary (n=13)* Pompe Phase 1/2 Study ATB200-02 Data at WMS FVC Increased in ERT-Naïve Patients and was Generally Stable in ERT-Switch Patients FVC (% Predicted): Month 6 and 9 *FVC results not available for 1 subject at Month 6 and 9 FVC stable or increased in 5/8 and 5/7 ERT-switch patients at Month 6 and Month 9 respectively FVC increased in 4/5 and 2/2 ERT-naïve patients at Month 6 and Month 9 respectively Cohort Baseline (n=9) Mean (SD) Change at Month 6 (n=8) Mean (SD) Change at Month 9 (n=7) Mean (SD) Cohort 1 ERT-Switch Ambulatory* 52.6 (14.7) -1.0 (4.2) -2.0 (3.6) Cohort Baseline (n=5) Mean (SD) Change at Month 6 (n=5) Mean (SD) Change at Month 9 (n=2) Mean (SD) Cohort 3 ERT-Naïve 53.4 (20.3) +4.2 (5.6) +5.0 (1.4)

Other Pulmonary Function Tests at Month 6 (n=14) Pompe Phase 1/2 Study ATB200-02 Data at WMS MIP and MEP Generally Stable or Increased in Both ERT-Naïve and ERT-Switch Patients Other Pulmonary Function Tests: MIP and MEP Patients Assessment Baseline (n=10) Mean (SD) Change at Month 6 (n=9) Mean (SD) Change at Month 9 (n=8) Mean (SD) Cohort 1: ERT-Switch MIP 35.7 (11.0) +0.9 (4.5) -1.4 (2.7) MEP 72.6 (32.6) +20.3 (42.4) +31.1 (39.3) Patients Assessment Baseline (n=5) Mean (SD) Change at Month 6 (n=5) Mean (SD) Change at Month 9 (n=2) Mean (SD) Cohort 3: ERT-Naive MIP 32.6 (18.5) +11.0 (5.0) +1.5 (0.7) MEP 60.6 (8.3) -0.4 (12.4) -1.0 (19.8)

Study ATB200-02 Data Summary Pompe Phase 1/2 Study ATB200-02 Data at WMS MIP Increased and MEP was Stable in ERT-Naïve Patients, MIP was Stable and MEP Increased in ERT-Switch Patients Consistent and Durable Improvement in Key Biomarkers and Muscle Function as well as Stabilization or Improvement in Respiratory Function Muscle function improved in 16/18 and 10/10 patients at Month 6 and 9, respectively 6MWT distance increased to Month 9 ERT-naïve: mean increases of +42m (Month 6) and +75m (Month 9) ERT-switch: mean increases of +35m (Month 6), +37m (Month 9) Improvement in other motor function tests consistent with 6MWT for both ERT-naïve and ERT-switch patients 4/4 non-ambulatory ERT-switch patients showed significant increase in muscle strength tests at Month 6 FVC generally stable in ERT-switch patients FVC increased in a majority of ERT-naïve patients MIP and MEP generally stable or improved in both ERT-switch and ERT-naïve patients Muscle Function (All Cohorts) Pulmonary Function (Cohorts 1 and 3)

Pompe Phase 1/2 Study ATB200-02 Data Cascade Novel ERT for Pompe Disease – ATB200 + Chaperone Continuing Collaborative Discussions with Regulators in the U.S. and EU Update Anticipated in the First Half of 2018 Pompe Milestones in 2017 Discussionswith U.S. and EU regulators 18-WEEK DATA Safety / tolerability Pharmacokinetics (PK) EXTENSION DATA Motor/pulmonary function 18-Week & Extension Data Presentation at World Muscle Society Additional 18-Week & Initial Extension Data Preliminary 18-Week Data at WORLDSymposium Biomarkers Immunogenicity

Thank you

Appendix

Pompe Disease Overview Pompe Disease is Heterogeneous Across a Broad Spectrum of Patients Pompe Overview Deficiency of GAA leading to glycogen accumulation Age of onset ranges from infancy to adulthood Symptoms include muscle weakness, respiratory failure, and cardiomyopathy Respiratory and cardiac failure are leading causes of morbidity and mortality 5,000 – 10,000 patients diagnosed WW1 ~$800M+ Global Pompe ERT sales in FY152 1. National Institute of Neurological Disorders and Stroke (NIH). 2. Sanofi Press Release & 10-K