| Cover | Jul. 14, 2022 |
| Cover [Abstract] | |
| Entity Central Index Key | 0001200375 |
| Document Type | 8-K |
| Document Period End Date | Jul. 14, 2022 |
| Entity Registrant Name | Codexis, Inc. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-34705 |
| Entity Tax Identification Number | 71-0872999 |
| Entity Address, City or Town | Redwood City |
| Entity Address, Postal Zip Code | 94063 |
| City Area Code | 650 |
| Local Phone Number | 421-8100 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, par value $0.0001 per share |
| Trading Symbol | CDXS |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
| Amendment Flag | false |
| Entity Address, Address Line One | 200 Penobscot Drive |
| Entity Address, State or Province | CA |
