Glaxosmithkline Capital 6-K Current report (foreign)

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM6-K

Report of Foreign Private Issuer

Pursuant to Rule13a-16 or15d-16 of

the Securities Exchange Act of 1934

May 10, 2018

GlaxoSmithKline plc GlaxoSmithKline Capital plc	GlaxoSmithKline Capital Inc.
(Name of registrant)	(Name of registrant)

980 Great West Road, Brentford, Middlesex, TW8 9GS	1105 North Market Street, Suite 1300, Wilmington, Delaware 19801
(Address of principal executive offices)	(Address of principal executive offices)

(Indicate by check mark whether the registrant files or will file annual reports under cover of Form20-F or Form40-F).

Form20-F  ☒            Form 40-F  ☐

Indicate by check mark if the registrant is submitting theForm 6-K in paper as permitted by RegulationS-T Rule 101(b)(1):             

Indicate by check mark if the registrant is submitting theForm 6-K in paper as permitted by RegulationS-T Rule 101(b)(7):             

THIS REPORT ON FORM 6-K SHALL BE DEEMED TO BE INCORPORATED BY REFERENCE IN THE PROSPECTUS INCLUDED IN THE REGISTRATION STATEMENT ON FORM F-3 (FILE NOS. 333-223982, 333-223982-01 AND 333-223982-02) OF GLAXOSMITHKLINE PLC, GLAXOSMITHKLINE CAPITAL PLC AND GLAXOSMITHKLINE CAPITAL INC. AND TO BE A PART THEREOF FROM THE DATE ON WHICH THIS REPORT IS FURNISHED, TO THE EXTENT NOT SUPERSEDED BY DOCUMENTS OR REPORTS SUBSEQUENTLY FILED OR FURNISHED.

This Report reflects the results of GlaxoSmithKline plc and its consolidated subsidiaries (“GSK”) for the first quarter of 2018, as previously announced by GSK on 25 April 2018 (the “Q1 2018 results announcement”). This Report speaks as of the time of the Q1 2018 results announcement and does not reflect events that may have occurred subsequent to such announcement.
First quarter 2018

GSK delivers Q1 sales of £7.2 billion,-2% AER, +4% CER

Total EPS 11.2p,-48% AER,-33% CER; Adjusted EPS 24.6p,-2% AER, +11% CER

Significant currency impact in the quarter reflecting movements in Sterling

Contents

	Page
Sales performance		2
Financial performance		7
Research and development		16
Definitions		19
Outlook assumptions and cautionary statements		20
Contacts		21
Income statement		22
Statement of comprehensive income		23
Pharmaceuticals turnover		24
Vaccines turnover		25
Balance sheet		26
Statement of changes in equity		27
Cash flow statement		28
Segment information		29
Legal matters		30
Taxation		30
Additional information		31
Reconciliation of cash flow to movements in net debt		34
Net debt analysis		34
Free cash flow reconciliation		34
Non-controlling interests in ViiV Healthcare		35
Adjusted results reconciliations		37

The results are presented under ‘Income Statement’ on page 22. The definitions of £% or AER% growth, CER% growth, Adjusted results, free cash flow and othernon-IFRS measures are set out on page 19 and reconciliations to the nearest IFRS measures are available on pages 9, 34, 37 and 38.

1

Press release

Sales performance

Group turnover by business and geographic region

Group turnover by business

	Q1 2018
	£m		Growth £%			Growth CER%
Pharmaceuticals		4,009		(4	)		2
Vaccines		1,238		7			13
Consumer Healthcare		1,975		(3	)		2
Group turnover		7,222		(2	)		4

Group turnover declined 2% AER but increased 4% CER to £7,222 million, with CER growth delivered by all three businesses.

Pharmaceuticals sales were down 4% AER but up 2% CER, reflecting the continued strong growth in HIV sales and growth fromNucala and theEllipta portfolio, including the first full quarter of sales ofTrelegy. This was partly offset by lower sales ofSeretide/Advair, Ventolin and Established Pharmaceuticals. Overall Respiratory sales declined 6% AER, but were flat at CER.

Vaccines sales were up 7% AER, 13% CER, primarily driven by sales ofShingrixin the US as well as increased demand forBexsero and Hepatitis vaccines, partly offset by declines in Established Vaccines andMenveo.

Consumer Healthcare sales declined 3% AER but grew 2% CER reflecting strong performances from power brands in the Pain relief and Oral health categories as well as Cold & flu seasonal brands, partly offset by the adverse comparison with launch sales forFlonase Sensimist in Q1 2017 and the impacts of generic competition toTransderm Scop in the US and the implementation of the Goods & Service Tax (GST) in India on 1 July 2017.

Group turnover by geographic region

	Q1 2018
	£m		Growth £%			Growth CER%
US		2,518		(4	)		7
Europe		2,041		2			—
International		2,663		(4	)		4
Group turnover		7,222		(2	)		4

US sales declined 4% AER, but grew 7% CER driven by strong performances fromTivicay andTriumeq, as well as contributions from the growth ofShingrix and Hepatitis vaccines.

Europe sales grew 2% AER, but were flat at CER as growth fromTivicay andTriumeq was offset by continued generic competition toEpzicom andAvodart. Growth in the new Respiratory products offset the decline inSeretide.

In International, sales declined 4% AER, but grew 4% CER reflecting strong growth inTivicay,Triumeq, the Respiratory portfolio andCervarix in China, following its recent launch. Sales in Emerging Markets declined 4% AER, but grew 4% CER.

2

Press release

Turnover – Q1 2018

Pharmaceuticals

	Q1 2018
	£m		Growth £%			Growth CER%
Respiratory		1,575		(6	)		—
HIV		1,048		6			14
Immuno-inflammation		100		9			20
Established Pharmaceuticals		1,286		(10	)		(5	)
		4,009		(4	)		2
US		1,570		(9	)		1
Europe		1,027		2			(1	)
International		1,412		(3	)		5
		4,009		(4	)		2

Pharmaceuticals turnover in the quarter was £4,009 million, down 4% AER, but up 2% CER, driven primarily by the growth in HIV sales, which were up 6% AER, 14% CER, to £1,048 million, reflecting continued strong performances byTriumeq andTivicay and initial sales ofJuluca. Respiratory sales declined 6% AER, but were flat at CER, to £1,575 million, with growth from theEllipta portfolio andNucala offset by lower sales ofSeretide/Advair andVentolin. Sales of Established Pharmaceuticals fell 10% AER, 5% CER, with the decline mitigated by someone-off contract sales in the quarter.

In the US, sales declined 9% AER but grew 1% at CER, with growth in the HIV portfolio andBenlysta offsetting declines in Established Products and Respiratory. Europe sales grew 2% AER but declined 1% CER, reflecting continued generic competition toEpzicom andAvodart and the ongoing transition of the Respiratory portfolio. International declined 3% AER but grew 5% CER, primarily driven by the new Respiratory portfolio.

Respiratory

Total Respiratory sales declined 6% AER, but were flat at CER, with the US down 14% AER, 4% CER. Europe sales grew 2% AER but declined 1% CER and International declined 2% AER but grew 6% CER, driven primarily by higher sales in Japan. Growth from theEllipta portfolio andNucala was offset by lower sales ofSeretide/Advair andVentolin.

Sales ofNucala were £104 million in the quarter, growing 76% AER, 86% CER, continuing to benefit from the global rollout of the product. US sales ofNucala grew 40% AER, 57% CER to £59 million, despite somede-stocking and increased competitive pressures from a new market entrant in the quarter.

Sales ofEllipta products were up 25% AER, 34% CER, driven by continued growth in all regions. In the US, sales grew 16% AER, 29% CER, reflecting further market share gains, partly offset by the impact of continued competitive pricing pressures. In Europe, sales grew 41% AER, 38% CER. Sales ofTrelegy Ellipta, our new, once daily closed tripleEllipta product, contributed £11 million in the quarter.

Relvar/Breo Ellipta sales grew 7% AER, 14% CER, to £219 million, primarily driven by growth in Europe, which was up 27% AER, 22% CER to £62 million, and in International, which was up 30% AER, 39% CER to £57 million. In the US,Breo Elliptasales declined 10% AER, but grew 1% CER, with volume growth of 44%, reflecting continued market share growth, almost entirely offset by the combined impact of prior period payer rebate adjustments (primarily an unfavourable comparison with rebate levels in Q1 2017) and increased competitive pricing pressure.Anoro Ellipta sales grew 56% AER, 68% CER to £97 million, driven by gains in the US. AllEllipta products,Breo,Anoro,Incruse,Arnuity and Trelegy, continued to grow market share in the US during the quarter.

3

Press release

Seretide/Advair sales declined 25% AER, 20% CER to £566 million. Sales ofAdvair in the US declined 32% AER, 25% CER (6% volume decline and 19% negative impact of price) primarily reflecting increased pricing and competitive pressures. In Europe,Seretide sales were down 19% AER, 21% CER to £166 million (9% volume decline and a 12% price decline). This reflected continued competition from generic products and the transition of the Respiratory portfolio to newer products. In International, sales ofSeretide were down 17% AER, 12% CER, to £171 million (9% volume decline and 3% negative impact of price), reflecting generic competition in certain markets and the continuing transition to the newer Respiratory products.

Pricing pressures also affected other Respiratory products, withVentolin sales declining 16% AER, 9% CER to £180 million.

HIV

HIV sales increased 6% AER, 14% CER to £1,048 million in the quarter, with the US up 3% AER, 15% CER, Europe up 15% AER, 12% CER and International up 3% at AER, up 11% CER. The growth was driven by continued increases in market share forTriumeq andTivicay, partly offset by the impact of generic competition toEpzicom/Kivexa, particularly affecting the European market. The ongoing increase in patient numbers for bothTriumeq andTivicay resulted in sales of £606 million and £348 million, respectively, in the quarter.Juluca was approved in the US in November 2017, and recorded sales of £10 million in its first full quarter.

Epzicom/Kivexa sales declined 53% AER, 52% CER to £37 million, reflecting ongoing generic competition.

Immuno-inflammation

Sales in the quarter were up 9% AER, 20% CER, primarily driven byBenlysta which grew 10% AER, 21% CER to £100 million. In the US, Benlysta grew 7% AER, 18% CER to £89 million including the contribution from thesub-cutaneous formulation launched in Q3 2017.

Established Pharmaceuticals

Sales of Established Pharmaceuticals in the quarter were £1,286 million, down 10% AER, 5% CER. The decline was mitigated by someone-off contract sales, including a post-divestment sale of raxibacumab inventory.

TheAvodart franchise was down 12% AER, 9% CER to £141 million, primarily due to the loss of exclusivity in Europe, with the US impact now broadly annualised.Coreg CR sales were lower following a generic entrant to the US market.Augmentin sales grew 6% AER, 12% CER to £164 million with improved demand in Emerging Markets.

4

Press release

Vaccines

	Q1 2018
	£m		Growth £%			Growth CER%
Meningitis		180		(6	)		(2	)
Influenza		9		(31	)		(23	)
Shingles		110		—			—
Established Vaccines		939		(1	)		3
		1,238		7			13
US		489		35			50
Europe		389		—			(3	)
International		360		(10	)		(6	)
		1,238		7			13

Vaccines turnover grew 7% AER, 13% CER to £1,238 million, primarily driven by growth in sales ofShingrix. Bexserosales also contributed, with growth across all regions driven by demand and share gains in the US, together with private market sales in International and Europe.Menveosales declined due to a strong comparator performancein Q1 2017 and supply constraints in International, partly offset by growth in the US. Established Vaccines growth was driven by Hepatitis vaccines, mainly due to a competitor supply shortage in the US, and the recent launch ofCervarixin China. These were partly offset by lowerSynflorixsales, driven by lower pricing in Emerging markets and unfavourable phasing, and increased competitive pressures onInfanrix, Pediarix in Europe and the US.

Meningitis

Meningitis sales declined 6% AER, 2% CER to £180 million.Bexserosales growth of 10% AER, 13% CER was driven by demand and share gains in the US, together with private market sales in International and Europe, and improved supply in Europe.Menveosales decreased by 33% AER, 25% CER, primarily reflecting a strong comparator performance in Q1 2017 and supply constraints in International, partly offset by favourableyear-on-year CDC purchases and higher demand in the US.

Influenza

Fluarix/FluLavalsales declined 31% AER, 23% CER to £9 million, due to an unfavourable comparison with Q1 2017, which saw some early deliveries, and increased competition in the quarter in International.

Shingles

Shingrixrecorded sales of £110 million in its first full quarter in the US and Canada, including continued building of wholesaler and other channel stocks.

Established Vaccines

Sales of the DTPa-containing vaccines (Infanrix,PediarixandBoostrix) were down 11% AER, 6% CER.Boostrixsales declined 10% AER, 5% CER to £100 million, primarily driven by the return to the market of a competitor in Europe and unfavourable prior year US wholesaler stocking patterns.Infanrix,Pediarixsales were down 12% AER, 6% CER to £206 million, reflecting increased competitive pressures in Europe and the US, partly offset by higher demand in International.

Hepatitis vaccines grew 17% AER, 24% CER to £195 million, benefiting from a competitor supply shortage and stronger demand in the US and Europe, partly offset by supply constraints in International.

Rotarixsales declined 11% AER, 6% CER to £130 million, mainly driven by the timing of tenders in International, partly offset by higher demand in Europe.

Synflorixsales were down 26% AER, 26% CER to £99 million, primarily driven by lower pricing and the unfavourable impact of phasing in Emerging Markets, partly offset by higher demand in International.

Cervarixsales were £52 million, more than double Q1 2017, primarily driven by its recent launch in China.

5

Press release

Consumer Healthcare

	Q1 2018
	£m		Growth £%			Growth CER%
Wellness		1,017		(5	)		—
Oral health		638		2			7
Nutrition		168		(8	)		(1	)
Skin health		152		(7	)		(2	)
		1,975		(3	)		2
US		459		(13	)		(3	)
Europe		625		5			2
International		891		(3	)		5
		1,975		(3	)		2

Consumer Healthcare sales declined 3% AER but grew 2% CER in the quarter to £1,975 million. The quarter saw strong performances in Oral health, Pain Relief and the Cold & flu seasonal brands, partly offset by the comparison with launch sales forFlonase Sensimistin Q1 2017. The generic competition toTransderm Scop in the US and the ongoing impact of the implementation of the Goods & Service Tax (GST) in India on 1 July 2017 impacted growth in the quarter by approximately two percentage points.

Wellness

Wellness sales declined 5% AER and were flat at CER at £1,017 million. Respiratory sales were down 7% AER, 2% CER with strong double-digit growth forTherafludriving share gains in the quarter and the benefit of a more severe US winter season more than offset by the comparison with the prior year launch sales forFlonase Sensimist.

Pain relief continued to perform well in the quarter, up 2% AER, 7% CER.Voltarendelivered broadly based consumption growth, driven by new marketing campaigns.Panadoldeliveredmid-single-digit growth with a strong performance in International markets also benefiting from a weak comparator in Australia in the prior year.

Transderm Scop generic competition, which started in July 2017, continued to build in the US during the quarter, leading to a decline of 69% AER, 65% CER compared with Q1 2017 and impacting overall Wellness growth in the quarter by approximately one percentage point.

Oral health

Oral health sales grew 2% AER, 7% CER to £638 million withSensodyne continuing to drive performance, reporting high single-digit CER growth, with strong delivery in the International region more than offsetting the comparison with new product launch sales in the US in Q1 2017. Sales of Denture care andParodontax grew in double digits, reflecting broadly based gains driven by increased dentist recommendation and innovation, includingParodontax Complete ProtectionandPolident Max Seal.

Nutrition

Nutrition sales declined 8% AER and 1% CER to £168 million, with growth adversely impacted by the implementation of GST in India in July 2017 which impacted overall Nutrition growth by 10 percentage points. Consumption growth accelerated forHorlicksin India, which benefited from strong marketing activities and new variant launches. The brands under strategic review represented approximately 80% of the overall Nutrition sales in the quarter.

Skin health

Skin health sales declined 7% AER, 2% CER to £152 million with a tough quarter forLamisil in International, in part reflecting timing impactsacross a number of smaller markets. This was partly offset by a good performance in Europe onLamisilandFenistil.Lip care also performed well in the peak winter season.

6

Press release

Financial performance – Q1 2018

Total results

The Total results for the Group are set out below.

	Q1 2018 £m			Q1 2017 £m			Growth £%			Growth CER%
Turnover		7,222			7,384			(2	)		4
Cost of sales		(2,391	)		(2,513	)		(5	)		(3	)
Gross profit		4,831			4,871			(1	)		7
Selling, general and administration		(2,311	)		(2,452	)		(6	)		(2	)
Research and development		(904	)		(960	)		(6	)		(1	)
Royalty income		53			82			(35	)		(34	)
Other operating income/(expense)		(429	)		177
Operating profit		1,240			1,718			(28	)		(15	)
Finance income		20			21
Finance expense		(162	)		(194	)
Share of after tax profits of associates and joint ventures		9			5
Profit before taxation		1,107			1,550			(29	)		(15	)
Taxation		(348	)		(327	)
Tax rate %		31.4	%		21.1	%
Profit after taxation		759			1,223			(38	)		(24	)
Profit attributable tonon-controlling interests		210			177
Profit attributable to shareholders		549			1,046
		759			1,223			(38	)		(24	)
Earnings per share		11.2	p		21.4	p		(48	)		(33	)

Cost of sales

Cost of sales as a percentage of turnover was 33.1%, down 0.9 percentage points at AER and 2.1 percentage points in CER terms compared with Q1 2017. This reflected a more favourable product mix in Pharmaceuticals in the quarter, particularly the impact of higher HIV sales. There was also a further contribution from integration and restructuring savings in all three businesses, together with lower costs from the manufacturing restructuring programmes. This was partly offset by continued adverse pricing pressure in Pharmaceuticals, particularly in Respiratory, and a negative mix impact in Established Vaccines.

Selling, general and administration

SG&A costs as a percentage of turnover were 32.0%, 1.2 percentage points lower than in Q1 2017 at AER and 1.7 percentage points lower on a CER basis. This primarily reflected lower restructuring and legal costs, as well as tight control of ongoing operating costs, particularly in Consumer Healthcare, and continued cost reductions in Pharmaceuticals. The improvement was partly offset by an increased investment in promotional product support, particularly for new launches in Respiratory, HIV and Vaccines.

Research and development

R&D expenditure was £904 million (12.5% of turnover), 6% lower than in Q1 2017 at AER and 1% lower at CER. This primarily reflected reduced restructuring costs and lower intangible asset impairments, offset by increased investment in the progression of a number of mid and late-stage programmes.

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Press release

Royalty income

Royalty income was £53 million (Q1 2017: £82 million), primarily reflecting the impact of the patent expiry of Cialis.

Other operating income/(expense)

Net other operating expense of £429 million (Q1 2017: £177 million income) primarily reflected £416 million (Q1 2017: £70 million) of accounting charges arising from there-measurement of the contingent consideration liabilities related to the acquisitions of the former Shionogi-ViiV Healthcare joint venture and the former Novartis Vaccines business, the value attributable to the Consumer Healthcare Joint Venture put option held by Novartis and the liabilities for the Pfizer put option and Pfizer and Shionogi preferential dividends in ViiV Healthcare.

These charges were driven primarily by the £495 million revaluation of the Consumer Healthcare Joint Venture put option to the consideration agreed with Novartis of $13 billion, discounted to the end of the quarter. Thisre-measurement charge was partly offset by accounting credits primarily related to changes in exchange rate assumptions on the valuation of the put option liability to Pfizer, and the valuation of the contingent consideration liability due to Shionogi, partly offset by the unwind of the discount.

In addition, Q1 2017 benefited from the gain of £245 million on the disposal of the anaesthesia business.

Operating profit

Total operating profit was £1,240 million in Q1 2018 compared with £1,718 million in Q1 2017. The reduction in operating profit reflected the increased impact of accounting charges related tore-measurement of the liability for the Consumer Healthcare put option and the benefit in Q1 2017 of the gain on the disposal of the anaesthesia business, as well as continuing price pressure, particularly in Respiratory, and supply chain investments, partly offset by tight control of ongoing costs and reduced restructuring costs.

Net finance costs

Net finance expense was £142 million compared with £173 million in Q1 2017. The reduction reflected the benefit of aone-off accounting adjustment to the amortisation of long term bond interest charges of approximately £20 million and the translation impact of exchange rate movements on the reported Sterling costs of foreign currency denominated interest-bearing instruments.

Taxation

The charge of £348 million represented an effective tax rate of 31.4% (Q1 2017: 21.1%) and reflected the differing tax effects of the various adjusting items.

Non-controlling interests

The allocation of earnings tonon-controlling interests amounted to £210 million (Q1 2017: £177 million), including thenon-controlling interest allocations of Consumer Healthcare profits of £89 million (Q1 2017: £63 million) and the allocation of ViiV Healthcare profits of £110 million (Q1 2017: £102 million). The allocation of ViiV Healthcare profits included the impact of changes in the proportions of preferential dividends due to each shareholder and the impact ofre-measurement charges.

Earnings per share

Total earnings per share was 11.2p, compared with 21.4p in Q1 2017. The reduction in earnings per share primarily reflected the increased impact of charges arising from increases in the valuation of the liability for the Consumer Healthcare put option and the benefit in Q1 2017 from the gain on disposal of the anaesthesia business. This was partly offset by improved trading performance and reduced restructuring and legal costs.

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Press release

Adjusting items

GSK presents Total results and Adjusted results in order to assist shareholders in better understanding the Group’s operational performance.

Total results represent the Group’s overall performance. However, these results can contain material unusual ornon-operational items that may obscure the key trends and factors determining the Group’s operational performance. GSK therefore also reports Adjusted results, which is anon-IFRS measure, to help shareholders identify and assess more clearly the key drivers of the Group’s performance. This approach aligns the presentation of the Group’s results more closely with the majority of GSK’s peer group.

Adjusted results exclude the following items from Total results: amortisation and impairments of intangible assets and goodwill; major restructuring costs; significant legal charges and expenses; transaction-related accounting adjustments; disposals and other operating income other than royalty income, together with the tax effect of all these items and the impact of the enactment of the US Tax Cuts and Jobs Act in 2017.

The adjusting items that reconcile Total operating profit, profit after tax and earnings per share to Adjusted results are as follows:

	Q1 2018						Q1 2017
	Operating profit £m		Profit after tax £m		Earnings per share p		Operating profit £m			Profit after tax £m			EPS p
Total results		1,240		759		11.2		1,718			1,223			21.4
Intangible asset amortisation		149		117		2.4		142			111			2.3
Intangible asset impairment		27		23		0.5		44			31			0.7
Major restructuring costs		65		49		1.0		166			129			2.7
Transaction-related items		437		457		9.0		92			65			0.9
Divestments, significant legal and other items		5		26		0.5		(183	)		(143	)		(3.0	)
Adjusting items		683		672		13.4		261			193			3.6
Adjusted results		1,923		1,431		24.6		1,979			1,416			25.0

Full reconciliations between Total results and Adjusted results are set out on pages 37 to 38 and the definition of Adjusted results is set out on page 19.

Intangible asset amortisation and impairment

Intangible asset amortisation was £149 million, compared with £142 million in Q1 2017. There were also intangible asset impairments of £27 million (Q1 2017: £44 million) related to a commercial asset in Consumer Healthcare. Both of these charges werenon-cash items.

Major restructuring and integration

Major restructuring and integration charges incurred in the quarter were £65 million (Q1 2017: £166 million).Non-cash charges were £17 million (Q1 2017: £20 million) and cash charges were £48 million (Q1 2017: £146 million). Cash payments made in the quarter were £104 million (Q1 2017: £213 million) including the settlement of certain charges accrued in previous quarters. The programme delivered incremental annual cost savings in the quarter of £0.1 billion.

Charges for the combined restructuring and integration programme to date are £4.8 billion, of which cash charges are £3.5 billion. Cash payments of £3.2 billion have been made to date.Non-cash charges are £1.3 billion.

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Total cash charges of the programme are now expected to be approximately £4.1 billion andnon-cash charges up to £1.6 billion. The programme has now delivered approximately £3.7 billion of annual savings, including a currency benefit of £0.4 billion. The programme is now expected to deliver by 2020 total annual savings of £4.0 billion on a constant currency basis, together with an estimated £0.4 billion of currency benefits on the basis of Q1 2018 average exchange rates.

Transaction-related adjustments

Transaction-related adjustments resulted in a net charge of £437 million (Q1 2017: £92 million). This primarily reflected £416 million of accounting charges for there-measurement of the contingent consideration liabilities related to the acquisitions of the former Shionogi-ViiV Healthcare joint venture and the former Novartis Vaccines business, the value attributable to the Consumer Healthcare Joint Venture put option held by Novartis and the liabilities for the Pfizer put option and Pfizer and Shionogi preferential dividends in ViiV Healthcare.

	Q1 2018 £m			Q1 2017 £m
Charge/(credit)
Consumer Healthcare Joint Venture put option		495			121
Contingent consideration on former Shionogi-ViiV Healthcare Joint Venture (including Shionogi preferential dividends)		(31	)		48
ViiV Healthcare put options and Pfizer preferential dividends		(61	)		(114	)
Contingent consideration on former Novartis Vaccines business		13			15
Other adjustments		21			22
Total transaction-related charges		437			92

Following the agreement to acquire Novartis’ interest in the Consumer Healthcare Joint Venture announced on 27 March 2018, a net charge of £495 million has been taken, primarily representing there-measurement of the valuation of the Consumer Healthcare put option to the agreed undiscounted valuation of $13 billion (£9.2 billion on signing). Between signing and 31 March 2018, the liability increased by £0.1 billion to £9.3 billion due to movements in exchange rates but the additional charge to reflect this increase was largely offset by gains on hedging contracts that are recorded separately in the balance sheet within Derivative financial instruments. The value of the liability has then been discounted by £106 million to £9.2 billion to reflect the present value of the liability at 31 March 2018 assuming an expected settlement on 1 June 2018.

The £31 million credit taken relating to the contingent consideration for the former Shionogi-ViiV Healthcare Joint Venture represented a £132 million reduction in the valuation of the contingent consideration due to Shionogi, primarily as a result of exchange rate assumptions on forecasts, partly offset by £101 million unwind of the discount. A credit of £61 million has been taken relating to a reduction in the put option liability to Pfizer, primarily as a result of exchange rate assumptions on forecasts.

Contingent consideration cash payments which are made to Shionogi and other companies reduce the balance sheet liability and hence are not recorded in the income statement. Total contingent consideration cash payments in the quarter amounted to £517 million (Q1 2017: £160 million). This included a cash milestone paid to Novartis of $450 million (£317 million), as well as cash payments made by ViiV Healthcare to Shionogi in relation to its contingent consideration liability (including preferential dividends) which amounted to £197 million (Q1 2017: £159 million).

An explanation of the accounting for thenon-controlling interests in ViiV Healthcare is set out on page 35.

Divestments, significant legal charges and other items

Divestments and other items included the profit on disposal of a number of other asset disposals, equity investment impairments and certain other adjusting items. A charge of £5 million (Q1 2017: £55 million) for significant legal matters included the benefit of the settlement of existing matters as well as provisions for ongoing litigation. Significant legal cash payments were £5 million (Q1 2017: £5 million).

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Adjusted results

	Q1 2018
	£m			% of turnover			Growth £%			Growth CER%
Turnover		7,222			100			(2	)		4
Adjusted cost of sales		(2,179	)		(30.2	)		(2	)		—
Adjusted selling, general and administration		(2,286	)		(31.7	)		(3	)		2
Adjusted research and development		(887	)		(12.3	)		(3	)		2
Royalty income		53			0.8			(35	)		(34	)
Adjusted operating profit		1,923			26.6			(3	)		9
Adjusted profit before tax		1,793						(1	)		11
Adjusted profit after tax		1,431						1			13
Adjusted profit attributable to shareholders		1,207						(1	)		12
Adjusted earnings per share		24.6	p					(2	)		11

Adjusted operating profit by business

	Q1 2018
	£m			% of turnover		Growth £%			Growth CER%
Pharmaceuticals		1,941			48.4		(8	)		(1	)
Pharmaceuticals R&D		(612	)				(10	)		(4	)
Total Pharmaceuticals		1,329			33.2		(8	)		—
Vaccines		339			27.4		—			18
Consumer Healthcare		384			19.4		9			18
		2,052			28.4		(4	)		6
Corporate & other unallocated costs		(129	)				(16	)		(30	)
Adjusted operating profit		1,923			26.6		(3	)		9

Adjusted operating profit

Adjusted operating profit was £1,923 million, 3% AER lower than in Q1 2017 and 9% CER higher on a turnover increase of 4%. The Adjusted operating margin of 26.6% was 0.2 percentage points lower at AER than in Q1 2017 but 1.3 percentage points higher on a CER basis. This primarily reflected sales growth in all three businesses, a more favourable mix and continued tight control of ongoing costs across all three businesses as well as benefits from restructuring and integration partly offset by continuing price pressure, particularly in Respiratory, supply chain investments and investments in promotional product support, particularly for new launches in Respiratory, HIV and Vaccines, and a reduction in royalty income.

Adjusted cost of sales

Cost of sales as a percentage of turnover was 30.2%, up 0.1 percentage points at AER, but down 0.9 percentage points in CER terms compared with Q1 2017. This reflected a more favourable product mix in Pharmaceuticals in the quarter, particularly the impact of higher HIV sales. There was also a further contribution from integration and restructuring savings in all three businesses. The improvement was partly offset by continued adverse pricing pressure in Pharmaceuticals, particularly in Respiratory, and in Established Vaccines.

Adjusted selling, general and administration

SG&A costs as a percentage of turnover were 31.7%, 0.1 percentage points lower at AER than in Q1 2017 and 0.6 percentage points lower on a CER basis. This primarily reflected tight control of ongoing costs, particularly in Consumer Healthcare, as well as further integration and restructuring savings. This was partly offset by increased investment in promotional product support, particularly for new launches in Respiratory, HIV and Vaccines.

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Adjusted research and development

R&D expenditure was £887 million (12.3% of turnover), 3% AER lower than Q1 2017 but 2% higher on a CER basis in comparison with a significantstep-up in expenditure in Q1 2017. The growth primarily reflected increased investment in the progression of a number of mid and late-stage programmes, partly offset by the benefit of the recent prioritisation initiatives.

Royalty income

Royalty income was £53 million (Q1 2017: £82 million), primarily reflecting the patent expiry of Cialis.

Adjusted operating profit by business

Pharmaceuticals operating profit was £1,329 million, down 8% AER, but flat at CER on a turnover increase of 2% CER. The operating margin of 33.2% was 1.2 percentage points lower at AER than in Q1 2017 and 0.6 percentage points lower on a CER basis. This reflected increased investment in new product support and the continued impact of lower prices, particularly in Respiratory, and the broader transition of the Respiratory portfolio as well as the reduction in royalty income as a result of the patent expiry of Cialis. The decline was partly offset by a more favourable product mix, primarily driven by the growth in HIV sales, as well as in prioritisation within R&D.

Vaccines operating profit was £339 million, flat at AER and 18% higher in CER terms on a turnover increase of 13% CER. The operating margin of 27.4% was 2.1 percentage points lower at AER than in Q1 2017, but 1.5 percentage points higher on a CER basis. This was primarily driven by improved product mix together with continued restructuring and integration benefits, partly offset by increased SG&A resources to support new launches and business growth.

Consumer Healthcare operating profit was £384 million, up 9% AER and 18% CER higher on a turnover increase of 2% CER. The operating margin of 19.4% was 2.2 percentage points higher than in Q1 2017 and 2.7 percentage points higher on a CER basis. This primarily reflected continued manufacturing restructuring and integration benefits and improved product mix as well as later phasing of promotional and other operating expenses compared with Q1 2017.

Adjusted net finance costs

Net finance expense was £139 million compared with £169 million in Q1 2017. The reduction primarily reflected the benefit of aone-off accounting adjustment to the amortisation of long term bond interest charges of £20 million as well as the translation impact of exchange rate movements on the reported Sterling costs of foreign currency denominated interest-bearing instruments.

Adjusted taxation

Tax on Adjusted profit amounted to £362 million and represented an effective Adjusted tax rate of 20.2% (Q1 2017: 22.0%). See ‘Taxation’ on page 30 for further details.

Adjusted earnings per share

Adjusted EPS of 24.6p was down 2% AER but up 11% CER, compared with a 9% CER increase in Adjusted operating profit.

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Currency impact on Q1 2018 results

The Q1 2018 results are based on average exchange rates, principally £1/$1.39, £1/€1.13 and £1/Yen 151. Comparative exchange rates are given on page 31. Theperiod-end exchange rates were £1/$1.40, £1/€1.14 and £1/Yen 149.

In the quarter, turnover reduced 2% in Sterling terms but increased 4% CER. Total EPS was 11.2p compared with EPS of 21.4p in Q1 2017 and Adjusted EPS was 24.6p compared with 25.0p in Q1 2017, down 2% AER, but up 11% CER. The negative currency impact primarily reflected the recent strength of Sterling, particularly against the US$ and Yen, relative to Q1 2017. Exchange gains or losses on the settlement of intercompany transactions contributed around one percentage point of the negative currency impact of thirteen percentage points on Adjusted EPS.

2018 guidance

The Group expects to make continued progress in 2018, although the expectation for Adjusted EPS growth is impacted by a number of factors including, in particular, uncertainties relating to the timing and extent of potential generic competition toAdvair in the US.

In the event that no substitutable generic competitor toAdvair is introduced to the US market in 2018, the Group continues to expect 2018 Adjusted EPS growth of 4 to 7% at CER. In the first quarter, the Group has made continued progress, with encouraging performances from new launches,Shingrix,Trelegy andJuluca and other new products, as well as agreeing the buyout of Novartis’ shareholding in the Consumer Healthcare Joint Venture, subject to shareholder approval. However, the Group has also seen increased pricing and competitive pressures in the US inhaled respiratory market in the first quarter, and GSK now expects a decline in 2018 US Advair sales of around 30% at CER.

In the event of amid-year introduction of a substitutable generic competitor toAdvair in the US, the Group expects full year 2018 US Advair sales of around £750 million at CER (US$1.30/£1), with Adjusted EPS flat to down 3% at CER.

The effective tax rate for 2018 is expected to be approximately19-20% of Adjusted profits after the impact of US tax reform which is expected to benefit the Group effective tax rate by two to three percentage points.

GSK is not able to give guidance for Total results as it cannot reliably forecast certain material elements of our Total results such as the future fair value movements on contingent consideration and put options and therefore a reconciliation of the guidance for Adjusted results to equivalent guidance for Total results is not available without unreasonable effort. It should be noted that contingent consideration cash payments are made each quarter primarily to Shionogi by ViiV Healthcare which reduce the balance sheet liability and are hence not recorded in the income statement. An explanation of the acquisition-related arrangements with ViiV Healthcare, including details of cash payments to Shionogi, is set out on page 35.

If exchange rates were to hold at the closing rates on 31 March 2018 ($1.40/£1, €1.14/£1 and Yen 149/£1) for the rest of 2018, the estimated negative impact on full-year 2018 Sterling turnover growth would be around 5% and if exchange gains or losses were recognised at the same level as in 2017, the estimated negative impact on 2018 Sterling Adjusted EPS growth would be around 8%.

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Cash generation and conversion

Cash flow and net debt

	Q1 2018			Q1 2017
Net cash inflow from operating activities (£m)		863			1,144
Free cash flow* (£m)		324			650
Free cash flow growth (%)		(50	)%		>100	%
Free cash flow conversion* (%)		59	%		62	%
Net debt (£m)		13,377			13,743

* Free cash flow and free cash flow conversion arenon-IFRS measures and are defined on page 19 and a reconciliation to the nearest IFRS measure is available on page 34.

Q1 2018

The net cash inflow from operating activities for the quarter was £863 million (Q1 2017: £1,144 million). The reduction primarily reflected the payment of the $450 million (£317 million) milestone to Novartis relating to thenon-US sales ofBexsero, of which £269 million was recognised in cashflows from operating activities and £48 million was recognised in contingent consideration paid within investing cash flows, as well as a negative currency impact on operating profit. This was partly offset by lower restructuring payments and a smaller increase in seasonal inventory and receivables compared with Q1 2017.

Total cash payments to Shionogi in relation to the ViiV Healthcare contingent consideration liability in the quarter were £197 million, of which £174 million was recognised in cash flows from operating activities and £23 million was recognised in contingent consideration paid within investing cash flows. These payments are deductible for tax purposes.

Free cash flow was £324 million for the quarter (Q1 2017: £650 million). The reduction primarily reflected the payment of the $450 million (£317 million) milestone to Novartis relating to thenon-US sales ofBexsero, as well as an £80 million quarterly dividend payment tonon-controlling interests and a negative currency impact on operating profit. This was partly offset by lower restructuring payments and capital expenditures as well as a smaller increase in seasonal inventory and receivables compared with Q1 2017.

Net debt

At 31 March 2018, net debt was £13.4 billion, compared with £13.2 billion at 31 December 2017, comprising gross debt of £17.5 billion and cash and liquid investments of £4.1 billion. Net debt increased as the reduced free cash flow of £0.3 billion, reflecting the milestone payment to Novartis, together with a £0.3 billion favourable exchange impact from the translation ofnon-Sterling denominated debt, was more than offset by the dividends paid to shareholders of £0.9 billion.

At 31 March 2018, GSK had short-term borrowings (including overdrafts) repayable within 12 months of £3.4 billion with loans of £1.3 billion repayable in the subsequent year.

Working capital

	31 March 2018		31 December 2017		30 September 2017		30 June 2017		31 March 2017
Working capital conversion cycle* (days)		204		191		210		207		203
Working capital percentage of turnover (%)		24		22		25		24		23

* Working capital conversion cycle is defined on page 19.

The increase in Q1 2018 of 13 days compared with December 2017 was predominantly due to seasonal factors and building of inventory for new product launches, a similar pattern to Q1 2017, the phasing of trade receivables and lower trade payables as a result of lower costs in the quarter.

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Returns to shareholders

Quarterly dividends

The Board has declared a first interim dividend for 2018 of 19 pence per share (Q1 2017: 19 pence per share).

GSK recognises the importance of dividends to shareholders and aims to distribute regular dividend payments that will be determined primarily with reference to the free cash flow generated by the business after funding the investment necessary to support the Group’s future growth.

The Board intends to maintain the dividend for 2018 at the current level of 80p per share, subject to any material change in the external environment or performance expectations. Over time, as free cash flow strengthens, it intends to build free cash flow cover of the annual dividend to a target range of1.25-1.50x, before returning the dividend to growth.

Payment of dividends

The equivalent interim dividend receivable by ADR holders will be calculated based on the exchange rate on 10 July 2018. An annual fee of $0.02 per ADS (or $0.005 per ADS per quarter) is charged by the Depositary.

Theex-dividend date will be 10 May 2018, with a record date of 11 May 2018 and a payment date of 12 July 2018.

	Paid/ payable		Pence per share		£m
2018
First interim		12 July 2018		19		933
2017
First interim		13 July 2017		19		928
Second interim		12 October 2017		19		929
Third interim		11 January 2018		19		929
Fourth interim		12 April 2018		23		1,130
				80		3,916

GSK made no share repurchases during the period. The company issued 1 million shares under employee share schemes for proceeds of £11 million (Q1 2017: £32 million).

The weighted average number of shares for Q1 2018 was 4,903 million, compared with 4,877 million in Q1 2017.

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Research and development

GSK remains focused on delivering an improved return on its investment in R&D. Sales contribution, reduced attrition, cost reduction and time to market are all important drivers of an improving internal rate of return. R&D expenditure is not determined as a percentage of sales but instead capital is allocated using strict returns based criteria depending on the pipeline opportunities available.

The R&D operations in Pharmaceuticals are broadly split into Discovery activities (up to the completion of Phase IIa trials) and Development work (from Phase IIb onwards) each supported by specific and common infrastructure and other shared services where appropriate. R&D expenditure for Q1 2018 is analysed below.

	Q1 2018 £m		Q1 2017 £m		Growth £%			Growth CER%
Discovery		206		250		(18	)		(12	)
Development		314		325		(3	)		4
Facilities and central support functions		146		147		(1	)		6
Pharmaceuticals		666		722		(8	)		(1	)
Vaccines		161		136		18			18
Consumer Healthcare		60		61		(2	)		3
Adjusted R&D		887		919		(3	)		2
Amortisation and impairment of intangible assets		10		20
Major restructuring costs		3		15
Divestments, significant legal and other items		4		6
Total R&D		904		960		(6	)		(1	)

In Q1 2018, Total R&D expenditure declined 6% AER, 1% CER. Adjusted R&D expenditure declined 3% AER, but increased 2% CER, with Pharmaceuticals down 8% AER, 1% CER. The reduced growth of Discovery primarily reflected the quarterly phasing of expenditure on specific programmes, including the transfer of certain oncology assets into the development phase. The increase in Vaccines R&D primarily reflected the benefit of comparison with favourable phasing of expenditure in Q1 2017.

R&D pipeline

Key Pharmaceuticals assets

At our Business update to investors on 26 July 2017, we confirmed an increased focus on delivery of several key assets in our Pharmaceuticals pipeline. We remain focused on delivering value and continue to evaluate and explore the best route to market for these assets, including potential options for partnering or collaborations.

Pipeline news flow since Q4 2017:

Vaccines

Our Vaccines business is one of the largest in the world with the broadest portfolio of any company. The focus of GSK Vaccines’ pipeline is to maintain GSK’s meningococcal meningitis market leadership with both licensed and candidate vaccines. In addition, we are pursuing a full RSV portfolio for infants, for maternal immunisation and for older adults, with different approaches tailored to the specific segments. This portfolio has the potential to deliver a series of first and/or best in class vaccines. In addition, we continue to leverage our unique technology platforms to target new, emerging or remaining medical needs.

Shingrix

• On 23 March 2018, GSK announced thatShingrix was approved in Europe and Japan for the prevention of shingles in adults aged 50 and over.

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Influenza vaccine

• On 6 March 2018, GSK announced new data published inThe Lancet Child & Adolescent Health from a Phase III clinical trial withFluarix Tetra (inactivated quadrivalent influenza vaccine) which prevented influenza A and B in children six to 35 months of age;

• On 15 February 2018, GSK announced the expanded indication forFluarix Tetra has been approved in Europe to include adults and now children from six months of age for the prevention of influenza disease caused by the two influenza A strains and the two influenza B strains contained in the vaccine.

Respiratory

GSK has been a leader in respiratory disease for nearly 50 years. We remain at the cutting-edge of scientific research into respiratory medicine, working in collaboration with patients and the scientific community to offer innovative medicines aimed at helping to treat patients’ symptoms and reduce the risk of their disease worsening. While respiratory diseases are clinically distinct, there are important pathophysiological features that span them, and our ambition is to have the most comprehensive portfolio of medicines to address a diverse range of respiratory diseases. To achieve this, we are focusing on targeting the underlying disease-driving biological processes to develop medicines with applicability across multiple respiratory diseases. This approach requires extensive bioinformatics, data analytic capabilities, careful patient selection and stratification by phenotype in our clinical trials.

Relvar/Breo Ellipta

• On 8 March 2018, GSK and Innoviva announced that the European Commission has approved a positive label update forRelvar Ellipta in patients with asthma;

• In March 2018, a phase IV study was commenced to evaluate the benefit of a Connected Inhaler System (CIS) on increasing adherence to maintenance treatment in patients with uncontrolled asthma usingRelvar Ellipta.

Trelegy Ellipta

• On 24 April 2018, GSK announced that once-dailyTrelegy Ellipta gained an expanded indication in the US for the treatment of patients with COPD based on evidence from the IMPACT study;

• On 18 April 2018, GSK and Innoviva announced landmark IMPACT study published in NEJM showing significant benefits ofTrelegy Ellipta for patients with COPD;

• On 14 February 2018, GSK and Innoviva announced the submission of the landmark IMPACT data to the European Medicines Agency as part of a type II variation to support an expanded label forTrelegy Ellipta in Europe for the maintenance treatment of moderate to severe chronic pulmonary disease (COPD).

Nucala

• On 5 March 2018 GSK, announced positive clinical study outcomes for severe eosinophilic asthma patients uncontrolled on omalizumab (Xolair) when switched to mepolizumab in an open-label single arm study.

HIV/Infectious diseases

GSK has a long-standing commitment to HIV and infectious diseases – our scientists discovered amoxycillin, the widely used antibiotic, over 40 years ago, and developed the first medicines approved to treat HIV (AZT), HBV (lamivudine), herpes viruses (acyclovir) and influenza (zanamivir). Today, we are investigating new medicines to treat, prevent and possibly, ultimately cure HIV and other infectious diseases. Our scientists are committed to developing medicines that advance HIV care by exploring new treatment paradigms(2-drug regimens), new modalities (long-acting injectables) and new mechanisms of actions (including maturation inhibitors and broadly neutralising antibodies).

Tivicay

• On 5 March 2018, ViiV Healthcare announced positive new dolutegravir data for the treatment of people living with HIVco-infected with tuberculosis. The INSPIRING study results contribute to the extensive body of evidence for dolutegravir, the leading integrase strand transfer inhibitor, in diverse and hard to treat patient populations.

Juluca

• On 23 March 2018, ViiV Healthcare announced that the European Committee for Medicinal Products for Human Use (CHMP) has issued a Positive Opinion recommending marketing authorisation forJuluca for the treatment of HIV infection in adults who are virologically suppressed.

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Dolutegravir + lamivudine

• On 8 February 2018, ViiV Healthcare announced the launch of the eight phase III study intwo-drug regimen programmes with the start of the TANGO study investigating dolutegravir (Tivicay) and lamivudine (Epivir) in patients with HIV who have achieved viral suppression on a tenofavir alafenamide fumarate-based regimen.

Immuno-inflammation

Immuno-inflammatory diseases are relatively common, chronic, debilitating conditions. While diverse in presentation, they are collectively hallmarked by impairment of quality of life and can lead to premature mortality. There is significant unmet need for improved treatment options for immuno-inflammatory diseases in terms of higher levels of remission and more durable maintenance of benefit. To discover the next breakthrough for immune-mediated diseases, we are working to develop transformational medicines that could potentially alter the course of inflammatory disease and induce sustainable remission. Our highly innovative discovery programme focuses on cytokines, chemokines and complement, epigenetics,T-cell biology and pattern recognition receptors.

Benlysta

• On 20 March 2018, GSK announced the start of a phase III study investigatingBenlysta (belimumab) in combination with rituximab in adult patients with systemic lupus erythematosus (SLE). This study will assess whetherco-administration enhances the treatment effect of belimumab and provides sustained disease control, which could lead to clinical remission.

Oncology

Cancer is one of the leading causes of death in the developed world. GSK is focused on delivering transformational therapies for cancer patients that may help to maximise their survival. GSK’s pipeline is focused on immuno-oncology, cell therapy, and epigenetics. Our goal is to achieve a sustainable flow of new treatments for cancer patients based on a diversified portfolio of investigational medicines utilising modalities such as small molecules, antibodies, multi-specific molecules, adjuvants and cells, either alone or in combination.

• There have been no further significant developments on the assets in this area since the Q4 2017 Results Announcement.

Future pipeline optionality

To retain scientific optionality outside of the four core areas, we have established three groups primarily focused on early stage activities in areas where the emerging science suggests the potential to develop future transformational medicines. These include Neuroscience, where GSK has several highly competitive programmes in the areas of neurodegeneration and neuro-excitation; Exploratory discovery, where we are pursuing novel targets in new pathways and emerging areas of science, and Global health discovery, with a particular focus on diseases of the developing world and other areas of global health.

Daprodustat

• Positive results in house from first of three phase III studies for daprodustat in Japan; data to be presented at an upcoming scientific conference.

Dezamizumab(anti-SAP mAb) + miridesap (SAP depleter)

• On 26 March 2018, the FDA grantedanti-SAP as a Fast Track development program for the treatment of systemic amyloidosis.

Rare diseases

• On 12 April 2018, GSK and Orchard Therapeutics announced a strategic agreement to transfer GSK’s portfolio of approved and investigational rare diseases gene therapies to Orchard, securing the continued development of the programmes and access for patients. GSK will continue to invest in the development of its platform capabilities in cell and gene therapies, with a focus on oncology.

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Definitions

GSK uses a number of adjusted,non-IFRS, measures to report the performance of its business. These measures are used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies and may not be directly comparable with similarly described measures used by other companies.Non-IFRS measures may be considered in addition to, but not as a substitute for or superior to, information presented in accordance with IFRS.

Total results

Total reported results represent the Group’s overall performance. However, these results can contain material unusual ornon-operational items that may obscure the key trends and factors determining the Group’s operational performance. As a result, GSK also reports Adjusted results, which is anon-IFRS measure.

Adjusted results

Adjusted results exclude the following items from Total results: amortisation and impairment of intangible assets (excluding computer software) and goodwill; major restructuring costs, including those costs following material acquisitions; significant legal charges (net of insurance recoveries) and expenses on the settlement of litigation and government investigations, transaction-related accounting adjustments for significant acquisitions, and other items, including disposals of associates, products and businesses and other operating income other than royalty income, together with the tax effects of all of these items and the impact of the enactment of the US Tax Cuts and Jobs Act in 2017.

GSK believes that Adjusted results are more representative of the performance of the Group’s operations and allow the key trends and factors driving that performance to be more easily and clearly identified by shareholders. The definition of Adjusted results, as set out above, also aligns the Group’s results with the majority of its peer companies and how they report earnings.

Reconciliations between Total and Adjusted results, as set out on pages 9, and 37 to 38, including detailed breakdowns of the key adjusting items, are provided to shareholders to ensure full visibility and transparency as they assess the Group’s performance.

Free cash flow

Free cash flow, which is anon-IFRS measure, is defined as the net cash inflow from operating activities less capital expenditure, contingent consideration payments, net interest, and dividends paid tonon-controlling interests plus proceeds from the sale of property, plant and equipment, and dividends received from joint ventures and associates. It is used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies. Free cash flow growth is calculated on a reported basis. A reconciliation of net cash inflow from operations to free cash flow is set out on page 34.

Free cash flow conversion

Free cash flow conversion is free cash flow as a percentage of earnings.

Working capital conversion cycle

The working capital conversion cycle is calculated as the number of days sales outstanding plus days inventory outstanding, less days purchases outstanding.

CER and AER growth

In order to illustrate underlying performance, it is the Group’s practice to discuss its results in terms of constant exchange rate (CER) growth. This represents growth calculated as if the exchange rates used to determine the results of overseas companies in Sterling had remained unchanged from those used in the comparative period. CER% represents growth at constant exchange rates. £% or AER% represents growth at actual exchange rates.

Brand names and partner acknowledgements

Brand names appearing in italics throughout this document are trademarks of GSK or associated companies or used under licence by the Group. Xolair is a trademark of Novartis AG and Cialis is a trademark of Eli Lilly and Company.

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Outlook assumptions and cautionary statements

Assumptions related to 2018 guidance and 2016-2020 outlook

In outlining the expectations for 2018 and the five-year period 2016-2020, the Group has made certain assumptions about the healthcare sector, the different markets in which the Group operates and the delivery of revenues and financial benefits from its current portfolio, pipeline and restructuring programmes.

For the Group specifically, over the period to 2020 GSK expects further declines in sales ofSeretide/Advair. The introduction of a generic alternative toAdvair in the US has been factored into the Group’s assessment of its future performance. The Group assumes no premature loss of exclusivity for other key products over the period.

The assumptions for the Group’s revenue and earnings expectations assume no material interruptions to supply of the Group’s products and no material mergers, acquisitions, disposals, litigation costs or share repurchases for the Company; and no change in the Group’s shareholdings in ViiV Healthcare or Consumer Healthcare (other than the buyout of Novartis’ shareholding, which is expected to complete on 1 June 2018, subject to shareholder approval). The assumptions also assume no material changes in the macro-economic and healthcare environment. The 2018 guidance and 2016-2020 outlook have factored in all divestments and product exits since 2015, including the divestment and exit of more than 130non-core tail brands (£0.5 billion in annual sales) as announced on 26 July 2017.

The Group’s expectations assume successful delivery of the Group’s integration and restructuring plans over the period 2016-2020 including the extension and enhancement to the combined programme announced on 26 July 2017. Material costs for investment in new product launches and R&D have been factored into the expectations given. Given the potential development options in the Group’s pipeline, the outlook may be affected by additional data-driven R&D investment decisions. The expectations are given on a constant currency basis (2016-2020 outlook at 2015 CER). Subject to material changes in the product mix, and following the enactment of US tax reform, the Group’s medium-term effective tax rate is expected to be in the region of19-20% of Adjusted profits. This incorporates management’s best estimates of the impact of US tax reform on the Group based on the information currently available. As more information on the detailed application of the US Tax Cuts and Jobs Act becomes available, the assumptions underlying these estimates could change with consequent adjustments to the charges taken that could have a material impact on the results of the Group.

Assumptions and cautionary statement regarding forward-looking statements

The Group’s management believes that the assumptions outlined above are reasonable, and that the aspirational targets described in this report are achievable based on those assumptions. However, given the longer term nature of these expectations and targets, they are subject to greater uncertainty, including potential material impacts if the above assumptions are not realised, and other material impacts related to foreign exchange fluctuations, macroeconomic activity, changes in regulation, government actions or intellectual property protection, actions by our competitors, and other risks inherent to the industries in which we operate.

This document contains statements that are, or may be deemed to be, “forward-looking statements”. Forward-looking statements give the Group’s current expectations or forecasts of future events. An investor can identify these statements by the fact that they do not relate strictly to historical or current facts. They use words such as ‘anticipate’, ‘estimate’, ‘expect’, ‘intend’, ‘will’, ‘project’, ‘plan’, ‘believe’, ‘target’ and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. In particular, these include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, the outcome of contingencies such as legal proceedings, and financial results. Other than in accordance with its legal or regulatory obligations (including under the Market Abuse Regulation, the UK Listing Rules and the Disclosure and Transparency Rules of the Financial Conduct Authority), the Group undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. The reader should, however, consult any additional disclosures that the Group may make in any documents which it publishes and/or files with the SEC. All readers, wherever located, should take note of these disclosures. Accordingly, no assurance can be given that any particular expectation will be met and investors are cautioned not to place undue reliance on the forward-looking statements.

Forward-looking statements are subject to assumptions, inherent risks and uncertainties, many of which relate to factors that are beyond the Group’s control or precise estimate. The Group cautions investors that a number of important factors, including those in this document, could cause actual results to differ materially from those expressed or implied in any forward-looking statement. Such factors include, but are not limited to, those discussed under Item 3.D ‘Risk Factors’ in the Group’s Annual Report on Form20-F for 2017. Any forward looking statements made by or on behalf of the Group speak only as of the date they are made and are based upon the knowledge and information available to the Directors on the date of this report.

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Contacts

GSK – one of the world’s leading research-based pharmaceutical and healthcare companies – is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For further information please visitwww.gsk.com.

GSK enquiries:

UK Media enquiries:	Simon Steel	+44 (0) 20 8047 5502	(London)
US Media enquiries:	Sarah Alspach	+1 202 715 1048	(Washington)
	Sarah Spencer	+1 215 751 3335	(Philadelphia)
Analyst/Investor enquiries:	Sarah Elton-Farr	+44 (0) 20 8047 5194	(London)
	James Dodwell	+44 (0) 20 8047 2406	(London)
	Danielle Smith	+44 (0) 20 8047 7562	(London)
	Tom Curry	+1 215 751 5419	(Philadelphia)
	Jeff McLaughlin	+1 215 751 7002	(Philadelphia)

Registered in England & Wales:

No. 3888792

Registered Office:

980 Great West Road

Brentford, Middlesex

TW8 9GS

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Financial information

Income statement

	Q1 2018 £m			Q1 2017 £m
TURNOVER		7,222			7,384
Cost of sales		(2,391	)		(2,513	)
Gross profit		4,831			4,871
Selling, general and administration		(2,311	)		(2,452	)
Research and development		(904	)		(960	)
Royalty income		53			82
Other operating income/(expense)		(429	)		177
OPERATING PROFIT		1,240			1,718
Finance income		20			21
Finance expense		(162	)		(194	)
Share of after tax profits of associates and joint ventures		9			5
PROFIT BEFORE TAXATION		1,107			1,550
Taxation		(348	)		(327	)
Tax rate %		31.4	%		21.1	%
PROFIT AFTER TAXATION FOR THE PERIOD		759			1,223
Profit attributable tonon-controlling interests		210			177
Profit attributable to shareholders		549			1,046
	759			1,223
EARNINGS PER SHARE		11.2	p		21.4	p
Diluted earnings per share		11.1	p		21.3	p

22

Press release

Statement of comprehensive income

	Q1 2018 £m			Q1 2017 £m
Profit for the period		759			1,223
Items that may be reclassified subsequently to income statement:
Exchange movements on overseas net assets and net investment hedges		66			196
Fair value movements on cash flow hedges		22			(2	)
Deferred tax on fair value movements on cash flow hedges		—			(1	)
Reclassification of cash flow hedges to income statement		(31	)		—
	57			193
Items that will not be reclassified to income statement:
Exchange movements on overseas net assets ofnon-controlling interests		(28	)		27
Fair value movements on equity investments		97			49
Deferred tax on fair value movements on equity investments		(9	)		(3	)
Re-measurement gains on defined benefit plans		186			234
Tax onre-measurement gains on defined benefit plans		(38	)		(55	)
	208			252
Other comprehensive income for the period		265			445
Total comprehensive income for the period		1,024			1,668
Total comprehensive income for the period attributable to:
Shareholders		842			1,464
Non-controlling interests		182			204
	1,024			1,668

23

Press release

Pharmaceuticals turnover – three months ended 31 March 2018

	Total								US								Europe								International
			Growth								Growth								Growth								Growth
	£m		£%			CER%			£m		£%			CER%			£m		£%			CER%			£m		£%			CER%
Respiratory		1,575		(6	)		—			662		(14	)		(4	)		388		2			(1	)		525		(2	)		6
Seretide/Advair		566		(25	)		(20	)		229		(32	)		(25	)		166		(19	)		(21	)		171		(17	)		(12	)
Elliptaproducts		386		25			34			207		16			29			103		41			38			76		36			43
Anoro Ellipta		97		56			68			60		50			67			24		71			71			13		62			62
Arnuity Ellipta		11		37			50			10		25			37			—		—			—			1		>100			>100
Incruse Ellipta		48		41			50			27		35			50			16		60			60			5		25			25
Relvar/Breo Ellipta		219		7			14			100		(10	)		1			62		27			22			57		30			39
Trelegy Ellipta		11		—			—			10		—			—			1		—			—			—		—			—
Nucala		104		76			86			59		40			57			31		>100			>100			14		>100			>100
Avamys/Veramyst		98		8			13			—		—			—			20		(5	)		(10	)		78		11			20
Flixotide/Flovent		158		(4	)		4			86		(3	)		7			27		(4	)		(7	)		45		(4	)		4
Ventolin		180		(16	)		(9	)		81		(31	)		(23	)		34		(3	)		(6	)		65		5			15
Other		83		(13	)		(4	)		—		—			—			7		(12	)		—			76		(12	)		(2	)
HIV		1,048		6			14			629		3			15			299		15			12			120		3			11
Epzicom/Kivexa		37		(53	)		(52	)		3		(79	)		(79	)		14		(64	)		(64	)		20		(23	)		(19	)
Juluca		10		—			—			10		—			—			—		—			—			—		—			—
Selzentry		29		(24	)		(16	)		15		(25	)		(15	)		9		(10	)		(10	)		5		(37	)		(25	)
Tivicay		348		15			24			228		14			27			88		26			21			32		—			13
Triumeq		606		12			20			366		2			13			182		36			32			58		29			38
Other		18		(30	)		(26	)		7		(50	)		(43	)		6		—			—			5		(14	)		(14	)
Immuno-inflammation		100		9			20			89		6			17			8		33			33			3		50			100
Benlysta		100		10			21			89		7			18			9		50			33			2		—			>100
Established Pharmaceuticals		1,286		(10	)		(5	)		190		(30	)		(22	)		332		(8	)		(11	)		764		(4	)		4
Dermatology		107		(5	)		—			1		>100			>100			39		(5	)		(7	)		67		(7	)		3
Augmentin		164		6			12			—		—			—			55		4			—			109		7			19
Avodart		141		(12	)		(9	)		3		(40	)		(20	)		64		(23	)		(24	)		74		3			10
Coreg		15		(57	)		(54	)		15		(57	)		(54	)		—		—			—			—		—			—
Eperzan/Tanzeum		13		(53	)		(48	)		12		(55	)		(50	)		1		(32	)		(34	)		—		—			—
Imigran/Imitrex		32		(40	)		(38	)		12		(60	)		(57	)		15		(6	)		(6	)		5		(29	)		(29	)
Lamictal		146		(12	)		(5	)		71		(20	)		(11	)		26		—			—			49		(4	)		4
Requip		21		(22	)		(19	)		2		(50	)		(50	)		6		—			—			13		(24	)		(18	)
Serevent		20		(23	)		(15	)		10		(33	)		(20	)		8		(11	)		(22	)		2		—			50
Seroxat/Paxil		40		(11	)		(4	)		—		—			—			10		11			11			30		(17	)		(8	)
Valtrex		28		(10	)		(3	)		3		(25	)		—			7		—			—			18		(10	)		(5	)
Zeffix		19		(27	)		(23	)		—		—			—			1		—			—			18		(28	)		(24	)
Other		540		(4	)		1			61		(1	)		8			100		(8	)		(12	)		379		(4	)		3
Pharmaceuticals		4,009		(4	)		2			1,570		(9	)		1			1,027		2			(1	)		1,412		(3	)		5

24

Press release

Vaccines turnover – three months ended 31 March 2018

	Total								US									Europe								International
	£m		Growth						£m			Growth						£m		Growth						£m		Growth
			£%			CER%						£%			CER%					£%			CER%					£%			CER%
Meningitis		180		(6	)		(2	)		55			20			33			99		(5	)		(8	)		26		(37	)		(24	)
Bexsero		139		10			13			31			15			26			92		11			7			16		—			25
Menveo		37		(33	)		(25	)		24			26			42			5		(69	)		(69	)		8		(60	)		(55	)
Other		4		(60	)		(60	)		—			—			—			2		(60	)		(60	)		2		(60	)		(60	)
Influenza		9		(31	)		(23	)		(1	)		(67	)		(67	)		1		—			—			9		(40	)		(33	)
Fluarix, FluLaval		9		(31	)		(23	)		(1	)		(67	)		(67	)		1		—			—			9		(40	)		(33	)
Shingles		110		—			—			102			—			—			—		—			—			8		—			—
Shingrix		110		—			—			102			—			—			—		—			—			8		—			—
Established Vaccines		939		(1	)		3			333			4			15			289		2			(1	)		317		(8	)		(5	)
Infanrix, Pediarix		206		(12	)		(6	)		106			(15	)		(6	)		73		(12	)		(14	)		27		4			19
Boostrix		100		(10	)		(5	)		46			(15	)		(4	)		37		(5	)		(8	)		17		(6	)		—
Hepatitis		195		17			24			112			32			47			59		16			12			24		(23	)		(19	)
Rotarix		130		(11	)		(6	)		47			(13	)		(4	)		29		32			27			54		(23	)		(19	)
Synflorix		99		(26	)		(26	)		—			—			—			13		(7	)		(7	)		86		(28	)		(29	)
Priorix, Priorix Tetra, Varilrix		77		—			(1	)		—			—			—			40		7			5			37		(7	)		(6	)
Cervarix		52		>100			>100			—			—			—			5		(29	)		(29	)		47		>100			>100
Other		80		27			30			22			>100			>100			33		7			7			25		(14	)		(14	)
Vaccines		1,238		7			13			489			35			50			389		—			(3	)		360		(10	)		(6	)

25

Press release

Balance sheet

	31 March 2018 £m			31 December 2017 £m
ASSETS
Non-current assets
Property, plant and equipment		10,661			10,860
Goodwill		5,601			5,734
Other intangible assets		17,290			17,562
Investments in associates and joint ventures		187			183
Other investments		961			918
Deferred tax assets		3,625			3,796
Derivative financial instruments		8			8
Othernon-current assets		1,403			1,413
Totalnon-current assets		39,736			40,474
Current assets
Inventories		5,659			5,557
Current tax recoverable		301			258
Trade and other receivables		6,106			6,000
Derivative financial instruments		152			68
Liquid investments		76			78
Cash and cash equivalents		4,004			3,833
Assets held for sale		125			113
Total current assets		16,423			15,907
TOTAL ASSETS		56,159			56,381
LIABILITIES
Current liabilities
Short-term borrowings		(3,442	)		(2,825	)
Contingent consideration liabilities		(732	)		(1,076	)
Trade and other payables		(21,088	)		(20,970	)
Derivative financial instruments		(100	)		(74	)
Current tax payable		(1,080	)		(995	)
Short-term provisions		(485	)		(629	)
Total current liabilities		(26,927	)		(26,569	)
Non-current liabilities
Long-term borrowings		(14,015	)		(14,264	)
Corporation tax payable		(396	)		(411	)
Deferred tax liabilities		(1,392	)		(1,396	)
Pensions and other post-employment benefits		(3,364	)		(3,539	)
Other provisions		(670	)		(636	)
Contingent consideration liabilities		(4,878	)		(5,096	)
Othernon-current liabilities		(927	)		(981	)
Totalnon-current liabilities		(25,642	)		(26,323	)
TOTAL LIABILITIES		(52,569	)		(52,892	)
NET ASSETS		3,590			3,489
EQUITY
Share capital		1,343			1,343
Share premium account		3,030			3,019
Retained earnings		(6,353	)		(6,477	)
Other reserves		1,911			2,047
Shareholders’ equity		(69	)		(68	)
Non-controlling interests		3,659			3,557
TOTAL EQUITY		3,590			3,489

26

Press release

Statement of changes in equity

	Share capital £m		Share premium £m		Retained earnings £m			Other reserves £m			Share- holder’s equity £m			Non- controlling interests £m			Total equity £m
As previously reported		1,343		3,019		(6,477	)		2,047			(68	)		3,557			3,489
Implementation of IFRS 15						(4	)					(4	)					(4	)
Implementation of IFRS 9						277			(288	)		(11	)					(11	)
At 1 January 2018, as adjusted		1,343		3,019		(6,204	)		1,759			(83	)		3,557			3,474
Profit for the period						549						549			210			759
Other comprehensive income for the period						198			95			293			(28	)		265
Total comprehensive income for the period						747			95			842			182			1,024
Distributions tonon-controlling interests															(80	)		(80	)
Dividends to shareholders						(929	)					(929	)					(929	)
Shares issued		—		11								11						11
Realised profits on disposal of equity investments						14			(14	)		—						—
Write-down on shares held by ESOP Trusts						(71	)		71									—
Share-based incentive plans						90						90						90
At 31 March 2018		1,343		3,030		(6,353	)		1,911			(69	)		3,659			3,590
At 1 January 2017		1,342		2,954		(5,392	)		2,220			1,124			3,839			4,963
Profit for the period						1,046						1,046			177			1,223
Other comprehensive income for the period						375			43			418			27			445
Total comprehensive income for the period						1,421			43			1,464			204			1,668
Distributions tonon-controlling interests															(161	)		(161	)
Dividends to shareholders						(925	)					(925	)					(925	)
Changes innon-controlling interests						(2	)					(2	)		(3	)		(5	)
Shares issued		1		31								32						32
Shares acquired by ESOP Trusts				10		70			(141	)		(61	)					(61	)
Write-down on shares held by ESOP Trusts						(160	)		160			—						—
Share-based incentive plans						82						82						82
At 31 March 2017		1,343		2,995		(4,906	)		2,282			1,714			3,879			5,593

27

Press release

Cash flow statement – three months ended 31 March 2018

	Q1 2018 £m			Q1 2017 £m
Profit after tax		759			1,223
Tax on profits		348			327
Share of after tax profits of associates and joint ventures		(9	)		(5	)
Net finance expense		142			173
Depreciation, amortisation and other adjusting items		478			326
Increase in working capital		(523	)		(604	)
Contingent consideration paid		(445	)		(138	)
Increase in other net liabilities (excluding contingent consideration paid)		311			48
Cash generated from operations		1,061			1,350
Taxation paid		(198	)		(206	)
Net cash inflow from operating activities		863			1,144
Cash flow from investing activities
Purchase of property, plant and equipment		(258	)		(260	)
Proceeds from sale of property, plant and equipment		9			13
Purchase of intangible assets		(97	)		(156	)
Proceeds from sale of intangible assets		5			—
Purchase of equity investments		(25	)		(21	)
Proceeds from sale of equity investments		22			6
Contingent consideration paid		(72	)		(22	)
Disposal of businesses		(9	)		223
Investment in associates and joint ventures		(1	)		(6	)
Interest received		16			24
Dividends from associates and joint ventures		39			—
Net cash outflow from investing activities		(371	)		(199	)
Cash flow from financing activities
Issue of share capital		11			32
Shares acquired by ESOP Trusts		—			(61	)
Increase in/(repayment of) short-term loans		701			(528	)
Net repayment of obligations under finance leases		(7	)		(3	)
Interest paid		(96	)		(93	)
Dividends paid to shareholders		(929	)		(925	)
Distributions tonon-controlling interests		(80	)		—
Other financing items		117			69
Net cash outflow from financing activities		(283	)		(1,509	)
Increase/(decrease) in cash and bank overdrafts in the period		209			(564	)
Cash and bank overdrafts at beginning of the period		3,600			4,605
Exchange adjustments		(52	)		11
Increase/(decrease) in cash and bank overdrafts		209			(564	)
Cash and bank overdrafts at end of the period		3,757			4,052
Cash and bank overdrafts at end of the period comprise:
Cash and cash equivalents		4,004			4,509
Overdrafts		(247	)		(457	)
	3,757			4,052

28

Press release

Segment information

Operating segments are reported based on the financial information provided to the Chief Executive Officer and the responsibilities of the Corporate Executive Team (CET). GSK reports results under four segments: Pharmaceuticals; Pharmaceuticals R&D; Vaccines and Consumer Healthcare, and individual members of the CET are responsible for each segment.

The Pharmaceuticals R&D segment is the responsibility of the President, Pharmaceuticals R&D and is reported as a separate segment.

The Group’s management reporting process allocates intra-Group profit on a product sale to the market in which that sale is recorded, and the profit analyses below have been presented on that basis.

Turnover by segment

	Q1 2018 £m		Q1 2017 £m		Growth £%			Growth CER%
Pharmaceuticals		4,009		4,189		(4	)		2
Vaccines		1,238		1,152		7			13
Consumer Healthcare		1,975		2,043		(3	)		2
Total turnover		7,222		7,384		(2	)		4

Operating profit by segment

	Q1 2018 £m			Q1 2017 £m			Growth £%			Growth CER%
Pharmaceuticals		1,941			2,118			(8	)		(1	)
Pharmaceuticals R&D		(612	)		(678	)		(10	)		(4	)
Pharmaceuticals including R&D		1,329			1,440			(8	)		—
Vaccines		339			341			—			18
Consumer Healthcare		384			351			9			18
Segment profit		2,052			2,132			(4	)		6
Corporate and other unallocated costs		(129	)		(153	)
Adjusted operating profit		1,923			1,979			(3	)		9
Adjusting items		(683	)		(261	)
Total operating profit		1,240			1,718			(28	)		(15	)
Finance income		20			21
Finance costs		(162	)		(194	)
Share of after tax profits of associates and joint ventures		9			5
Profit before taxation		1,107			1,550			(29	)		(15	)

29

Press release

Legal matters

The Group is involved in significant legal and administrative proceedings, principally product liability, intellectual property, tax, anti-trust and governmental investigations as well as related private litigation, which are more fully described in the ‘Legal Proceedings’ note in the Annual Report 2017.

At 31 March 2018, the Group’s aggregate provision for legal and other disputes (not including tax matters described under ‘Taxation’ below) was £0.2 billion (31 December 2017: £0.2 billion). The Group may become involved in significant legal proceedings in respect of which it is not possible to make a reliable estimate of the expected financial effect, if any, that could result from ultimate resolution of the proceedings. In these cases, the Group would provide appropriate disclosures about such cases, but no provision would be made.

The ultimate liability for legal claims may vary from the amounts provided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations. The Group’s position could change over time, and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group’s financial accounts.

There have been no significant legal developments since the date of the Annual Report 2017.

Developments with respect to tax matters are described in ‘Taxation’ below.

Taxation

Issues related to taxation are described in the ‘Taxation’ note in the Annual Report 2017. The Group continues to believe it has made adequate provision for the liabilities likely to arise from periods which are open and not yet agreed by tax authorities. The ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of agreements with relevant tax authorities. There have been no material changes to historical tax matters since the date of the Annual Report 2017.

In the quarter, tax on Total profits amounted to £348 million and represented an effective tax rate of 31.4% (Q1 2017: 21.1%). The rate of 31.4% has been influenced by thenon-taxable transaction – related charges arising on the Group’s put option liabilities. The tax on Adjusted profits amounted to £362 million and represented an effective Adjusted tax rate of 20.2% (Q1 2017: 22.0%).

The Group’s balance sheet at 31 March 2018 included a current tax payable liability of £1,080 million, anon-current tax payable liability of £396 million and a tax recoverable asset of £301 million.

30

Press release

Additional information

Accounting policies and basis of preparation

This unaudited Results Announcement contains condensed financial information for the three months ended 31 March 2018 and should be read in conjunction with the Annual Report 2017, which was prepared in accordance with International Financial Reporting Standards as adopted by the European Union. This Results Announcement has been prepared applying consistent accounting policies to those applied by the Group in the Annual Report 2017, except for the implementation of IFRS 15 ‘Revenue from contracts with customers’ and IFRS 9 ‘Financial instruments’ from 1 January 2018. These new Standards have not had a material impact on the reported results.

GSK has adopted IFRS 15 applying the modified retrospective approach, with a cumulative adjustment to decrease equity at 1 January 2018 by £4 million. In accordance with the requirements of the Standard, where the modified retrospective approach is adopted, prior year results are not restated. GSK has adopted IFRS 9 retrospectively, but with certain permitted exceptions. As a result, prior year results are also not restated, but a cumulative adjustment to decrease equity at 1 January 2018 by £11 million has been made.

IFRS 16 ‘Leases’ is required to be implemented by the Group from 1 January 2019. The new standard will replace IAS 17 ‘Leases’ and will require lease liabilities and “right of use” assets to be recognised on the balance sheet for almost all leases. This is expected to result in a significant increase in both assets and liabilities recognised on the balance sheet. The costs of operating leases currently included within operating costs will be split and the financing element of the charge will be reported within finance expense. The Group is assessing the potential impact of the new standard.

This Results Announcement does not constitute statutory accounts of the Group within the meaning of sections 434(3) and 435(3) of the Companies Act 2006. The full Group accounts for 2017 were published in the Annual Report 2017, which has been delivered to the Registrar of Companies and on which the report of the independent auditors was unqualified and did not contain a statement under section 498 of the Companies Act 2006.

Exchange rates

GSK operates in many countries, and earns revenues and incurs costs in many currencies. The results of the Group, as reported in Sterling, are affected by movements in exchange rates between Sterling and other currencies. Average exchange rates, as modified by specific transaction rates for large transactions, prevailing during the period, are used to translate the results and cash flows of overseas subsidiaries, associates and joint ventures into Sterling.Period-end rates are used to translate the net assets of those entities. The currencies which most influenced these translations and the relevant exchange rates were:

	Q1 2018		Q1 2017		2017
Average rates:
US$/£		1.39		1.25		1.30
Euro/£		1.13		1.17		1.15
Yen/£		151		141		145
Period-end rates:
US$/£		1.40		1.25		1.35
Euro/£		1.14		1.17		1.13
Yen/£		149		139		152

During Q1 2018, average Sterling exchange rates were weaker against the Euro but stronger against the US Dollar and the Yen, compared with the same period in 2017.Period-end Sterling exchange rates were stronger against the US Dollar and the Euro, but weaker against the Yen, compared with the 2017 year end rates.

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Weighted average number of shares

	Q1 2018 millions		Q1 2017 millions
Weighted average number of shares – basic		4,903		4,877
Dilutive effect of share options and share awards		42		41
Weighted average number of shares – diluted		4,945		4,918

At 31 March 2018, 4,913 million shares were in free issue (excluding Treasury shares and shares held by the ESOP Trusts). This compares with 4,886 million shares at 31 March 2017.

Net assets

The book value of net assets increased by £101 million from £3,489 million at 31 December 2017 to £3,590 million at 31 March 2018. This primarily reflected the Total profit for the period andre-measurement gains on defined benefit plans exceeding the dividend paid in the period.

The carrying value of investments in associates and joint ventures at 31 March 2018 was £187 million (31 December 2017: £183 million), with a market value of £377 million (31 December 2017: £372 million).

At 31 March 2018, the net deficit on the Group’s pension plans was £1,350 million compared with £1,505 million at 31 December 2017. The decrease in the net deficit primarily arose from increases in the rates used to discount UK pension liabilities from 2.5% to 2.6%, and US pension liabilities from 3.6% to 3.9% together with a decrease in the UK inflation rate from 3.2% to 3.1%, partly offset by lower asset values.

At 31 March 2018, the post-retirement benefits provision was £1,405 million compared with £1,496 million at 31 December 2017. The decrease in the provision was primarily due to a weaker US Dollar at the period end.

At 31 March 2018, the Consumer Healthcare Joint Venture put option was recognised in Other payables in Current liabilities at a value of £9,179 million and represented the present value of the agreed valuation of $13 billion following the announcement on 27 March 2018 of the agreement to buyout Novartis’ interest in the Consumer Healthcare Joint Venture (31 December 2017: £8,606 million). This is expected to be settled on 1 June 2018, at which point the liability will be extinguished. The estimated present value of the potential redemption amount of the Pfizer put option related to ViiV Healthcare, also recorded in Other payables in Current liabilities, was £1,243 million (31 December 2017: £1,304 million).

Contingent consideration amounted to £5,610 million at 31 March 2018 (31 December 2017: £6,172 million), of which £5,314 million (31 December 2017: £5,542 million) represented the estimated present value of amounts payable to Shionogi relating to ViiV Healthcare and £251 million (31 December 2017: £584 million) represented the estimated present value of contingent consideration payable to Novartis related to the Vaccines acquisition. A milestone payment of $450 million was made to Novartis in January 2018. The liability due to Shionogi included £215 million in respect of preferential dividends. The liability for preferential dividends due to Pfizer at 31 March 2018 was £17 million (31 December 2017: £17 million). An explanation of the accounting for thenon-controlling interests in ViiV Healthcare is set out on page 35.

Of the contingent consideration payable (on apost-tax basis) at 31 March 2018, £732 million (31 December 2017: £1,076 million) is expected to be paid within one year. The consideration payable for the acquisition of the Shionogi-ViiV Healthcare joint venture and the Novartis Vaccines business is expected to be paid over a number of years. As a result, the total estimated liabilities are discounted to their present values, on apost-tax basis usingpost-tax discount rates. The Shionogi-ViiV Healthcare contingent consideration liability is discounted at 8.5% and the Novartis Vaccines contingent consideration liability is discounted partly at 8% and partly at 9%.

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The liabilities for the put options and the contingent consideration at 31 March 2018 have been calculated based on the closing exchange rates, primarily US$1.40/£1 and Euro €1.14/£1. The sensitivities to these exchange rates for Consumer Healthcare and ViiV Healthcare put options and the Shionogi-ViiV Healthcare and Novartis Vaccines contingent consideration liabilities are set out below.

	Consumer Healthcare Joint Venture put option			ViiV Healthcare put option			Shionogi- ViiV Healthcare contingent consideration			Novartis Vaccines contingent consideration
	£m			£m			£m			£m
Increase/(decrease) in liability
5 cent appreciation of US Dollar		340			32			150			(5	)
5 cent depreciation of US Dollar		(317	)		(30	)		(141	)		4
10 cent appreciation of US Dollar		706			67			312			(9	)
10 cent depreciation of US Dollar		(612	)		(58	)		(272	)		8
5 cent appreciation of Euro					19			47			12
5 cent depreciation of Euro					(18	)		(42	)		(11	)
10 cent appreciation of Euro					41			96			25
10 cent depreciation of Euro					(34	)		(79	)		(21	)

Movements in contingent consideration are as follows:

	Q1 2018 £m			Q1 2017 £m
Contingent consideration at beginning of the period		6,172			5,896
Re-measurement through income statement		(45	)		58
Cash payments: operating cash flows		(445	)		(138	)
Cash payments: investing activities		(72	)		(22	)
Contingent consideration at end of the period		5,610			5,794

There-measurements of contingent consideration in the quarter reflected updated forecasts, exchange rate movements and the unwind of the discounts on the liabilities. The cash settlement in the period included £197 million (Q1 2017: £159 million) of payments to Shionogi in relation to ViiV Healthcare and the £317 million milestone payment to Novartis relating to thenon-US sales ofBexsero. These payments are deductible for tax purposes.

At 31 March 2018, the ESOP Trusts held 46.4 million GSK shares against the future exercise of share options and share awards. The carrying value of £312 million has been deducted from other reserves. The market value of these shares was £646 million.

At 31 March 2018, the company held 414.6 million Treasury shares at a cost of £5,800 million, which has been deducted from retained earnings.

Contingent liabilities

There were contingent liabilities at 31 March 2018 in respect of guarantees and indemnities entered into as part of the ordinary course of the Group’s business. No material losses are expected to arise from such contingent liabilities. Provision is made for the outcome of legal and tax disputes where it is both probable that the Group will suffer an outflow of funds and it is possible to make a reliable estimate of that outflow. Descriptions of the significant legal and tax disputes to which the Group is a party are set out on page 30.

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Reconciliation of cash flow to movements in net debt

	Q1 2018 £m			Q1 2017 £m
Net debt at beginning of the period		(13,178	)		(13,804	)
Increase/(decrease) in cash and bank overdrafts		209			(564	)
Net (increase in)/repayment of short-term loans		(701	)		528
Net repayment of obligations under finance leases		7			3
Exchange adjustments		267			97
Othernon-cash movements		19			(3	)
(Increase)/decrease in net debt		(199	)		61
Net debt at end of the period		(13,377	)		(13,743	)

Net debt analysis

	31 March 2018 £m			31 December 2017 £m
Liquid investments		76			78
Cash and cash equivalents		4,004			3,833
Short-term borrowings		(3,442	)		(2,825	)
Long-term borrowings		(14,015	)		(14,264	)
Net debt at end of the period		(13,377	)		(13,178	)

Free cash flow reconciliation

	Q1 2018 £m			Q1 2017 £m
Net cash inflow from operating activities		863			1,144
Purchase of property, plant and equipment		(258	)		(260	)
Proceeds from sale of property, plant and equipment		9			13
Purchase of intangible assets		(97	)		(156	)
Net finance costs		(80	)		(69	)
Dividends from joint ventures and associates		39			—
Contingent consideration paid (reported in investing activities)		(72	)		(22	)
Distributions tonon-controlling interests		(80	)		—
Free cash flow		324			650

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Non-controlling interests in ViiV Healthcare

Trading profit allocations

Because ViiV Healthcare is a subsidiary of the Group, 100% of its operating results (turnover, operating profit, profit after tax) are included within the Group income statement and then a portion of the earnings is allocated to thenon-controlling interests owned by the other shareholders, in line with their respective equity shareholdings (Pfizer 11.7% and Shionogi 10%). Each of the shareholders, including GSK, is also entitled to preferential dividends determined by the performance of certain products that each shareholder contributed. As the relative performance of these products changes over time, the proportion of the overall earnings of ViiV Healthcare allocated to each shareholder will change. In particular, the increasing sales ofTivicay andTriumeq have a favourable impact on the proportion of the preferential dividends that is allocated to GSK. GSK was entitled to approximately 80% of the Adjusted earnings of ViiV Healthcare for 2017.Re-measurements of the liabilities for the preferential dividends allocated to Pfizer and Shionogi are included within other operating income.

Acquisition-related arrangements

As part of the agreement reached to acquire Shionogi’s interest in the former Shionogi-ViiV Healthcare joint venture in 2012, ViiV Healthcare agreed to pay additional consideration to Shionogi contingent on the performance of the products being developed by that joint venture, principally dolutegravir. The liability for this contingent consideration was estimated and recognised in the balance sheet at the date of acquisition. Subsequentre-measurements are reflected within other operating income/expense and within Adjusting items in the income statement.

Cash payments are made to Shionogi by ViiV Healthcare each quarter which reduce the balance sheet liability and are hence not recorded in the income statement. The payments are calculated based on the sales performance of the relevant products in the previous quarter and are reflected in the cash flow statement partly in operating cash flows and partly within investing activities. The tax relief on these payments is reflected in the Group’s Adjusting items as part of the tax charge. The part of each payment relating to the original estimate of the fair value of the contingent consideration on the acquisition of the Shionogi-ViiV Healthcare joint venture in 2012 of £659 million is reported within investing activities in the cash flow statement and the part of each payment relating to the increase in the liability since the acquisition is reported within operating cash flows.

Movements in contingent consideration payable to Shionogi are as follows:

	Q1 2018 £m			Q1 2017 £m
Contingent consideration at beginning of the period		5,542			5,304
Re-measurement through income statement		(31	)		48
Cash payments: operating cash flows		(174	)		(137	)
Cash payments: investing activities		(23	)		(22	)
Contingent consideration at end of the period		5,314			5,193

Of the contingent consideration payable (on apost-tax basis) to Shionogi at 31 March 2018, £703 million (31 March 2017: £579 million) is expected to be paid within one year.

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Exit rights

Pfizer may request an IPO of ViiV Healthcare at any time and if either GSK does not consent to such IPO or an offering is not completed within nine months, Pfizer could require GSK to acquire its shareholding. Under the original agreements, GSK had the unconditional right, so long as it made no subsequent distribution to its shareholders, to withhold its consent to the exercise of the Pfizer put options and, as a result, in accordance with IFRS, GSK did not recognise a liability for the put option on its balance sheet. However, during Q1 2016, GSK notified Pfizer that it had irrevocably given up this right and accordingly recognised the liability for the put option on the Group’s balance sheet during Q1 2016 at an initial value of £1,070 million. Consistent with this revised treatment, at the end of Q1 2016 GSK also recognised liabilities for the future preferential dividends anticipated to become payable to Pfizer and Shionogi on the Group’s balance sheet.

The closing balances of the liabilities related to Pfizer’s shareholding are as follows:

	Q1 2018 £m		31 December 2017 £m
Pfizer put option		1,243		1,304
Pfizer preferential dividend		17		17

Under the original agreements, Shionogi could also have requested GSK to acquire its shareholding in ViiV Healthcare in six month windows commencing in 2017, 2020 and 2022. GSK had the unconditional right, so long as it made no subsequent distribution to its shareholders, to withhold its consent to the exercise of the Shionogi put option and, as a result, GSK did not recognise a liability for the put option on its balance sheet. However, during Q1 2016, GSK notified Shionogi that it had irrevocably given up this right and accordingly recognised the liability for the put option on the Group’s balance sheet during Q1 2016 at an initial value of £926 million. In Q4 2016, Shionogi irrevocably agreed to waive its put option and as a result GSKde-recognised the liability for this put option on the Group’s balance sheet directly to equity. The value of the liability was £1,244 million when it wasde-recognised.

GSK also has a call option over Shionogi’s shareholding in ViiV Healthcare, which under the original agreements was exercisable in six month windows commencing in 2027, 2030 and 2032. GSK has now irrevocably agreed to waive the first two exercise windows, but the last six month window in 2032 remains. As this call option is at fair value, it has no value for accounting purposes.

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Adjusted results reconciliations

The reconciliations between Total results and Adjusted results for Q1 2018 and Q1 2017 are set out below.

Income statement – Adjusted results reconciliation

Three months ended 31 March 2018

	Total results £m			Intangible amort- isation £m			Intangible impair- ment £m			Major restruct- uring £m			Transaction- related £m			Divestments, significant legal and other items £m			Adjusted results £m
Gross profit		4,831			139			27			43			3						5,043
Operating profit		1,240			149			27			65			437			5			1,923
Profit before taxation		1,107			149			27			66			437			7			1,793
Profit after taxation		759			117			23			49			457			26			1,431
Earnings per share		11.2	p		2.4	p		0.5	p		1.0	p		9.0	p		0.5	p		24.6	p
Weighted average number of shares (millions)		4,903																		4,903
The following adjustments are made in arriving at Adjusted gross profit
Cost of sales		(2,391	)		139			27			43			3						(2,179	)
The following adjustments are made in arriving at Adjusted operating profit
Selling, general and administration		(2,311	)								19						6			(2,286	)
Research and development		(904	)		10						3						4			(887	)
Other operating income		(429	)											434			(5	)		—
The following adjustments are made in arriving at Adjusted profit before tax
Net finance costs		(142	)								1						2			(139	)
The following adjustments are made in arriving at Adjusted profit after tax
Taxation		(348	)		(32	)		(4	)		(17	)		20			19			(362	)

Adjusted results exclude the above items from Total results as GSK believes that Adjusted results are more representative of the performance of the Group’s operations and allow the key trends and factors driving performance to be more easily and clearly identified by shareholders. For a fuller explanation of Adjusted results, see ‘Definitions’ on page 19.

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Income statement – Adjusted results reconciliation

Three months ended 31 March 2017

	Total results £m			Intangible amort- isation £m			Intangible impair- ment £m			Major restruct- uring £m			Transaction- related £m			Divestments, significant legal and other items £m			Adjusted results £m
Gross profit		4,871			131			35			104			22						5,163
Operating profit		1,718			142			44			166			92			(183	)		1,979
Profit before taxation		1,550			142			44			167			92			(180	)		1,815
Profit after taxation		1,223			111			31			129			65			(143	)		1,416
Earnings per share		21.4p			2.3p			0.7p			2.7p			0.9p			(3.0	)p		25.0p
Weighted average number of shares (millions)		4,877																		4,877
The following adjustments are made in arriving at Adjusted gross profit
Cost of sales		(2,513	)		131			35			104			22						(2,221	)
The following adjustments are made in arriving at Adjusted operating profit
Selling, general and administration		(2,452	)								47						58			(2,347	)
Research and development		(960	)		11			9			15						6			(919	)
Other operating income		177												70			(247	)		—
The following adjustments are made in arriving at Adjusted profit before tax
Net finance costs		(173	)								1						3			(169	)
The following adjustments are made in arriving at Adjusted profit after tax
Taxation		(327	)		(31	)		(13	)		(38	)		(27	)		37			(399	)

Adjusted results exclude the above items from Total results as GSK believes that Adjusted results are more representative of the performance of the Group’s operations and allow the key trends and factors driving performance to be more easily and clearly identified by shareholders. For a fuller explanation of Adjusted results, see ‘Definitions’ on page 19.

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrants have duly caused this report to be signed on their behalf by the undersigned, thereunto duly authorised.

Date: May 10, 2018

GlaxoSmithKline plc GlaxoSmithKline Capital plc and GlaxoSmithKline Capital Inc. (Registrants)
By:	/s/ VICTORIA WHYTE
	Victoria Whyte
	Authorised Signatory for and on behalf of GlaxoSmithKline plc GlaxoSmithKline Capital plc and GlaxoSmithKline Capital Inc.