The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | W EXP 12/24/201 | 00289Y115 | 11,966 | 1,259,636 | SH | SOLE | 1,259,636 | 0 | 0 | ||
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 14,180 | 998,162 | SH | SOLE | 998,162 | 0 | 0 | ||
| ABIOMED INC | COM | 003654100 | 96,739 | 332,449 | SH | SOLE | 332,449 | 0 | 0 | ||
| ABLYNX NV | SPONSORED ADR | 00372Y105 | 20,187 | 370,000 | SH | SOLE | 370,000 | 0 | 0 | ||
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 6,179 | 275,000 | SH | SOLE | 275,000 | 0 | 0 | ||
| ACASTI PHARMA INC | COM | 00430K402 | 190 | 186,559 | SH | SOLE | 186,559 | 0 | 0 | ||
| ACCELERON PHARMA INC | COM | 00434H108 | 59,286 | 1,516,259 | SH | SOLE | 1,516,259 | 0 | 0 | ||
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 3,710 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 15,057 | 630,000 | SH | SOLE | 630,000 | 0 | 0 | ||
| ADMA BIOLOGICS INC | COM | 000899104 | 17,577 | 3,821,102 | SH | SOLE | 3,821,102 | 0 | 0 | ||
| ADVAXIS INC | COM NEW | 007624208 | 2,535 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 469 | 80,845 | SH | SOLE | 80,845 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 9,072 | 3,530,000 | SH | SOLE | 3,530,000 | 0 | 0 | ||
| AGIO PHARMACEUTICALS INC | COM | 00847X104 | 20,445 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
| AKCEA THERAPEUTICS INC | COM | 00972L107 | 2,488 | 97,144 | SH | SOLE | 97,144 | 0 | 0 | ||
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 23,467 | 2,462,400 | SH | SOLE | 2,462,400 | 0 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 55,510 | 1,704,330 | SH | SOLE | 1,704,330 | 0 | 0 | ||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 23,141 | 3,085,458 | SH | SOLE | 3,085,458 | 0 | 0 | ||
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 97,355 | 873,450 | SH | SOLE | 873,450 | 0 | 0 | ||
| ALLENA PHARMACEUTICALS INC | COM | 018119107 | 2,755 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
| ALLIQUA BIOMEDICAL INC | COM PAR | 019621309 | 821 | 423,394 | SH | SOLE | 423,394 | 0 | 0 | ||
| ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 152,543 | 1,280,802 | SH | SOLE | 1,280,802 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 301,167 | 20,024,424 | SH | SOLE | 20,024,424 | 0 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 24,696 | 237,281 | SH | SOLE | 237,281 | 0 | 0 | ||
| ANI PHARMACEUTICALS INC | NOTE 3.000%12/0 | 00182CAA1 | 8,214 | 7,500,000 | PRN | SOLE | 7,500,000 | 0 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 6,793 | 171,978 | SH | SOLE | 171,978 | 0 | 0 | ||
| ARGENX SE-ADR | COM | 04016X101 | 43,225 | 537,361 | SH | SOLE | 537,361 | 0 | 0 | ||
| ARRAY BIOPHARMA INC | COM | 04269X105 | 655 | 40,133 | SH | SOLE | 40,133 | 0 | 0 | ||
| ARROWHEAD PHARMACEUTICALS INC | COM | 04280A100 | 2,635 | 365,445 | SH | SOLE | 365,445 | 0 | 0 | ||
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 64,265 | 982,647 | SH | SOLE | 982,647 | 0 | 0 | ||
| ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 23,421 | 476,626 | SH | SOLE | 476,626 | 0 | 0 | ||
| ATHENEX INC | COM | 04685N103 | 3,232 | 190,000 | SH | SOLE | 190,000 | 0 | 0 | ||
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 22,724 | 756,215 | SH | SOLE | 756,215 | 0 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 9,447 | 1,295,841 | SH | SOLE | 1,295,841 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 7,129 | 2,458,116 | SH | SOLE | 2,458,116 | 0 | 0 | ||
| AVEXIS INC | COM | 05366U100 | 34,158 | 276,400 | SH | SOLE | 276,400 | 0 | 0 | ||
| AZURRX BIOPHARMA INC | COM | 05502L105 | 714 | 227,272 | SH | SOLE | 227,272 | 0 | 0 | ||
| BEIGENE LTD | SPONSORED | 07725L102 | 958 | 5,700 | SH | SOLE | 5,700 | 0 | 0 | ||
| BIOGEN INC | COM | 09062X103 | 11 | 50,000 | SH | Call | SOLE | 50,000 | 0 | 0 | |
| BIOGEN INC | COM | 09062X103 | 5,476 | 20,000 | SH | SOLE | 20,000 | 0 | 0 | ||
| BIOHAVEN PHARMACEUTICAL HLDG CO L | COM | G11196105 | 71,224 | 2,927,449 | SH | SOLE | 2,927,449 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 94,491 | 1,030,434 | SH | SOLE | 1,030,434 | 0 | 0 | ||
| BRAINSTORM CELL THERAPEUTICS | COM NEW | 10501E201 | 1,260 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| CAPITAL SR LIVING CORP | COM | 140475104 | 1,077 | 100,173 | SH | SOLE | 100,173 | 0 | 0 | ||
| CAPRICOR THERAPEUTICS INC | COM | 14070B101 | 5 | 4,000 | SH | SOLE | 4,000 | 0 | 0 | ||
| CAREDX INC | COM | 14167L103 | 8,294 | 1,040,676 | SH | SOLE | 1,040,676 | 0 | 0 | ||
| CASI PHARMACEUTICALS INC | COM | 14757U109 | 182 | 43,682 | SH | SOLE | 43,682 | 0 | 0 | ||
| CATALYST BIOSCIENCES IINC | COM NEW | 14888D208 | 1,419 | 55,000 | SH | SOLE | 55,000 | 0 | 0 | ||
| CELLECTIS S A | SPONSORED ADS | 15117K103 | 9,453 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM NEW | 15870P307 | 1,335 | 366,973 | SH | SOLE | 366,973 | 0 | 0 | ||
| CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 7,681 | 715,181 | SH | SOLE | 715,181 | 0 | 0 | ||
| CORIUM INTERNATIONAL INC | COM | 21887L107 | 72,916 | 6,357,133 | SH | SOLE | 6,357,133 | 0 | 0 | ||
| CUTERA INC | COM | 232109108 | 602 | 11,981 | SH | SOLE | 11,981 | 0 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 33,745 | 2,802,821 | SH | SOLE | 2,802,821 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 62,841 | 2,208,812 | SH | SOLE | 2,208,812 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 48,296 | 2,093,498 | SH | SOLE | 2,093,498 | 0 | 0 | ||
| DOVA PHARMACEUTICALS INC | COM | 25985T102 | 75,420 | 2,780,977 | SH | SOLE | 2,780,977 | 0 | 0 | ||
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 1,106 | 55,713 | SH | SOLE | 55,713 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,553 | 157,679 | SH | SOLE | 157,679 | 0 | 0 | ||
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 | 739 | 9,132 | SH | SOLE | 9,132 | 0 | 0 | ||
| ENDOCYTE INC | COM | 29269A102 | 20,013 | 2,201,700 | SH | SOLE | 2,201,700 | 0 | 0 | ||
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 779 | 10,769 | SH | SOLE | 10,769 | 0 | 0 | ||
| FERRARI N V | COM | N3167Y103 | 747 | 6,200 | SH | SOLE | 6,200 | 0 | 0 | ||
| FIAT CHRYSLER AUTOMOBILES N | SHS | N31738102 | 1,272 | 62,000 | SH | SOLE | 62,000 | 0 | 0 | ||
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 6,902 | 307,989 | SH | SOLE | 307,989 | 0 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | COM | M46135105 | 5,732 | 1,117,324 | SH | SOLE | 1,117,324 | 0 | 0 | ||
| GALAPAGOS N V | SPON ADR | 36315X101 | 20,581 | 206,305 | SH | SOLE | 206,305 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 600 | 600,000 | SH | Put | SOLE | 600,000 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 240,971 | 4,989,066 | SH | SOLE | 4,989,066 | 0 | 0 | ||
| HISTOGENICS CORP | COM | 43358V109 | 6,059 | 2,203,277 | SH | SOLE | 2,203,277 | 0 | 0 | ||
| HUMANA INC | COM | 444859102 | 16,323 | 60,718 | SH | SOLE | 60,718 | 0 | 0 | ||
| HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 296 | 10,000 | SH | SOLE | 10,000 | 0 | 0 | ||
| INCYTE CORP | COM | 45337C102 | 6,946 | 1,510,000 | SH | Call | SOLE | 1,510,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 2,230 | 100,000 | SH | Put | SOLE | 100,000 | 0 | 0 | |
| INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 1,474 | 70,000 | SH | SOLE | 70,000 | 0 | 0 | ||
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 4,128 | 10,000 | SH | SOLE | 10,000 | 0 | 0 | ||
| INVACARE CORP | COM | 461203101 | 3,480 | 200,000 | SH | SOLE | 200,000 | 0 | 0 | ||
| INVITAE CORP | COM | 46185L103 | 8,700 | 1,851,100 | SH | SOLE | 1,851,100 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 104,141 | 6,162,202 | SH | SOLE | 6,162,202 | 0 | 0 | ||
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 26,420 | 419,706 | SH | SOLE | 419,706 | 0 | 0 | ||
| KADMON HLDGS INC | COM | 48283N106 | 21,954 | 5,165,746 | SH | SOLE | 5,165,746 | 0 | 0 | ||
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 128,459 | 4,313,611 | SH | SOLE | 4,313,611 | 0 | 0 | ||
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 16,645 | 142,522 | SH | SOLE | 142,522 | 0 | 0 | ||
| MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 3,467 | 907,732 | SH | SOLE | 907,732 | 0 | 0 | ||
| MCKESSON CORP | COM | 58155Q103 | 2,113 | 15,000 | SH | SOLE | 15,000 | 0 | 0 | ||
| MENLO THERAPEUTICS INC | COM | 586858102 | 60,089 | 1,598,958 | SH | SOLE | 1,598,958 | 0 | 0 | ||
| MERIT MED SYS INC | COM | 589889104 | 47,391 | 1,045,013 | SH | SOLE | 1,045,013 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 893 | 29,091 | SH | SOLE | 29,091 | 0 | 0 | ||
| MOLECULAR TEMPLATES INC | COM | 608550109 | 5,793 | 724,133 | SH | SOLE | 724,133 | 0 | 0 | ||
| MOTUS GI HLDGS INC | COM | 62014P108 | 12,591 | 2,810,542 | SH | SOLE | 2,810,542 | 0 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 40,732 | 834,679 | SH | SOLE | 834,679 | 0 | 0 | ||
| NEKTAR THERAPEUTICS | COM | 640268108 | 644 | 6,057 | SH | SOLE | 6,057 | 0 | 0 | ||
| NEPTUNE TECHNOLOGIES BIORESO | COM | 64077P108 | 24,092 | 8,574,015 | SH | SOLE | 8,574,015 | 0 | 0 | ||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 394,912 | 4,761,989 | SH | SOLE | 4,761,989 | 0 | 0 | ||
| NUVECTRA CORP | COM | 67075N108 | 5,007 | 384,600 | SH | SOLE | 384,600 | 0 | 0 | ||
| ODONATE THERAPEUTICS INC | COM | 676079106 | 3,177 | 150,000 | SH | SOLE | 150,000 | 0 | 0 | ||
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 8,334 | 2,620,897 | SH | SOLE | 2,620,897 | 0 | 0 | ||
| ONCOSEC MED INC | COM NEW | 68234L207 | 94 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| PERNIX THERAPEUTICS HLDGS IN | DBVC 4.250% 4/0 | 71426VAK4 | 462 | 1,000,000 | PRN | SOLE | 1,000,000 | 0 | 0 | ||
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 14,370 | 440,000 | SH | SOLE | 440,000 | 0 | 0 | ||
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 158 | 100,000 | SH | Put | SOLE | 100,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 1,212 | 162,500 | SH | SOLE | 162,500 | 0 | 0 | ||
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 835 | 334,116 | SH | SOLE | 334,116 | 0 | 0 | ||
| PTC THERAPEUTICS INC | COM | 69366J200 | 8,118 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 1,610 | 200,000 | SH | Call | SOLE | 200,000 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 30,090 | 442,179 | SH | SOLE | 442,179 | 0 | 0 | ||
| QUOTIENT LTD | COM | G73268107 | 28,415 | 6,033,020 | SH | SOLE | 6,033,020 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 335 | 50,000 | SH | Call | SOLE | 50,000 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 26,301 | 881,106 | SH | SOLE | 881,106 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 71,839 | 3,212,871 | SH | SOLE | 3,212,871 | 0 | 0 | ||
| REVANCE THERAPEUTICS INC | COM | 761330109 | 19,064 | 618,957 | SH | SOLE | 618,957 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 11,786 | 592,286 | SH | SOLE | 592,286 | 0 | 0 | ||
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 475 | 25,000 | SH | SOLE | 25,000 | 0 | 0 | ||
| SELECTA BIOSCIENCES INC | COM | 816212104 | 6,050 | 593,750 | SH | SOLE | 593,750 | 0 | 0 | ||
| SENSEONICS HLDGS INC | COM | 81727U105 | 345 | 115,000 | SH | SOLE | 115,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 10,350 | 5,000,000 | SH | SOLE | 5,000,000 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 3422E1055 | 29,454 | 3,927,222 | SH | SOLE | 3,927,222 | 0 | 0 | ||
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 1,548 | 900,000 | SH | Put | SOLE | 900,000 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 2,434 | 275,000 | SH | SOLE | 275,000 | 0 | 0 | ||
| SYNERGY PHARMACEUTICALS DEL | COM NEW | 871639308 | 183 | 100,000 | SH | SOLE | 100,000 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 8,844 | 942,852 | SH | SOLE | 942,852 | 0 | 0 | ||
| TABULA RASA HEALTHCARE INC | COM | 873379101 | 569 | 14,663 | SH | SOLE | 14,663 | 0 | 0 | ||
| TELADOC INC | COM | 87918A105 | 20,956 | 520,000 | SH | SOLE | 520,000 | 0 | 0 | ||
| TELEFLEX INC | COM | 879369106 | 10,429 | 40,900 | SH | SOLE | 40,900 | 0 | 0 | ||
| UNIQURE NV | COM | N90064101 | 32,774 | 1,394,628 | SH | SOLE | 1,394,628 | 0 | 0 | ||
| VBI VACCINES INC | COM NEW | 91822J103 | 33,830 | 9,665,843 | SH | SOLE | 9,665,843 | 0 | 0 | ||
| VERICEL CORP | COM | 92346J108 | 271 | 27,211 | SH | SOLE | 27,211 | 0 | 0 | ||
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 1,123 | 56,168 | SH | SOLE | 56,168 | 0 | 0 | ||
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 24,756 | 151,898 | SH | SOLE | 151,898 | 0 | 0 | ||
| VICAL INC | COM | 925602203 | 1,657 | 1,142,858 | SH | SOLE | 1,142,858 | 0 | 0 | ||
| VIEWRAY INC | COM | 92672L107 | 643 | 100,000 | SH | SOLE | 100,000 | 0 | 0 | ||
| VITAL THERAPIES INC | COM | 92847R104 | 454 | 150,000 | SH | Put | SOLE | 150,000 | 0 | 0 | |
| VIVEVE MED INC | COM NEW | 92852W204 | 1,226 | 334,894 | SH | SOLE | 334,894 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 18,558 | 462,798 | SH | SOLE | 462,798 | 0 | 0 | ||
| XENCOR INC | COM | 98401F105 | 39,516 | 1,318,095 | SH | SOLE | 1,318,095 | 0 | 0 | ||
| ZOGENIX INC | COM NEW | 98978L204 | 159,012 | 3,970,357 | SH | SOLE | 3,970,357 | 0 | 0 | ||
| ZYMEWORKS INC | COM | 98985W102 | 7,779 | 693,890 | SH | SOLE | 693,890 | 0 | 0 | ||