The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | W EXP 12/24/201 | 00289Y115 | 12,810 | 1,259,636 | SH | SOLE | 0 | 1,259,636 | 0 | 0 | |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 954 | 59,662 | SH | SOLE | 0 | 59,662 | 0 | 0 | |
| ABIOMED INC | COM | 003654100 | 14,990 | 36,646 | SH | SOLE | 0 | 36,646 | 0 | 0 | |
| ACASTI PHARMA INC | CL A NEW | 00430K402 | 117 | 206,677 | SH | SOLE | 0 | 206,677 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 74,149 | 1,528,205 | SH | SOLE | 0 | 1,528,205 | 0 | 0 | |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 2,830 | 1,000,000 | SH | SOLE | 0 | 1,000,000 | 0 | 0 | |
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 28,004 | 1,084,159 | SH | SOLE | 0 | 1,084,159 | 0 | 0 | |
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 585 | 49,302 | SH | SOLE | 0 | 49,302 | 0 | 0 | |
| ADMA BIOLOGICS INC | COM | 000899104 | 29,410 | 6,521,102 | SH | SOLE | 0 | 6,521,102 | 0 | 0 | |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 428 | 80,845 | SH | SOLE | 0 | 80,845 | 0 | 0 | |
| AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 272 | 25,694 | SH | SOLE | 0 | 25,694 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 1,744 | 3,530,000 | SH | SOLE | 0 | 3,530,000 | 0 | 0 | |
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 22,110 | 2,215,400 | SH | SOLE | 0 | 2,215,400 | 0 | 0 | |
| ALBIREO PHARMA INC | COM | 01345P106 | 60,504 | 1,704,330 | SH | SOLE | 0 | 1,704,330 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 24,529 | 3,085,458 | SH | SOLE | 0 | 3,085,458 | 0 | 0 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 57,537 | 463,450 | SH | SOLE | 0 | 463,450 | 0 | 0 | |
| ALLENA PHARMACEUTICALS INC | COM | 018119107 | 3,258 | 250,000 | SH | SOLE | 0 | 250,000 | 0 | 0 | |
| ALLIQUA BIOMEDICAL INC | COM PAR | 019621309 | 867 | 423,394 | SH | SOLE | 0 | 423,394 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 181,902 | 1,846,911 | SH | SOLE | 0 | 1,846,911 | 0 | 0 | |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 312,782 | 20,024,424 | SH | SOLE | 0 | 20,024,424 | 0 | 0 | |
| ANI PHARMACEUTICALS INC | NOTE 3.005 12/0 | 00182CAA1 | 8,458 | 7,500,000 | PRN | SOLE | 0 | 7,500,000 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 36,710 | 841,978 | SH | SOLE | 0 | 841,978 | 0 | 0 | |
| ARGENX SE ADR | ADR | 04016X101 | 43,879 | 529,560 | SH | SOLE | 0 | 529,560 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 673 | 40,133 | SH | SOLE | 0 | 40,133 | 0 | 0 | |
| ARROWHEAD PHARMACEUTICALS INC | COM | 04280A100 | 4,970 | 365,445 | SH | SOLE | 0 | 365,445 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 71,352 | 1,072,647 | SH | SOLE | 0 | 1,072,647 | 0 | 0 | |
| ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 5,909 | 150,695 | SH | SOLE | 0 | 150,695 | 0 | 0 | |
| ATHENAHEALTH INC | COM | 04685W103 | 23,871 | 150,000 | SH | SOLE | 0 | 150,000 | 0 | 0 | |
| ATHENEX INC | COM | 04685N103 | 3,545 | 190,000 | SH | SOLE | 0 | 190,000 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 25,234 | 660,406 | SH | SOLE | 0 | 660,406 | 0 | 0 | |
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 4,274 | 1,891,192 | SH | SOLE | 0 | 1,891,192 | 0 | 0 | |
| AXOGEN INC | COM | 05463X106 | 8,291 | 165,000 | SH | SOLE | 0 | 165,000 | 0 | 0 | |
| AZURRX BIOPHARMA INC | COM | 05502L105 | 730 | 227,272 | SH | SOLE | 0 | 227,272 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 876 | 5,700 | SH | SOLE | 0 | 5,700 | 0 | 0 | |
| BIOHAVEN PHARMACEUTICAL HOLDING CO L | COM | G11196105 | 108,429 | 2,743,647 | SH | SOLE | 0 | 2,743,647 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 61,014 | 961,147 | SH | SOLE | 0 | 961,147 | 0 | 0 | |
| CAPITAL SR LIVING CORP | COM | 140475104 | 1,069 | 100,173 | SH | SOLE | 0 | 100,173 | 0 | 0 | |
| CAPRICOR THERAPEUTICS INC | COM | 14070B101 | 5 | 4,000 | SH | SOLE | 0 | 4,000 | 0 | 0 | |
| CAREDX INC | COM | 14167L103 | 5,724 | 467,676 | SH | SOLE | 0 | 467,676 | 0 | 0 | |
| CASI PHARMACEUTICALS INC | COM | 14757U109 | 360 | 43,682 | SH | SOLE | 0 | 43,682 | 0 | 0 | |
| CHAMPIONS ONCOLOGY INC | COM NEW | 158990812 | 2,326 | 366,972 | SH | SOLE | 0 | 366,972 | 0 | 0 | |
| CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 7,599 | 707,581 | SH | SOLE | 0 | 707,581 | 0 | 0 | |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 577 | 24,213 | SH | SOLE | 0 | 24,213 | 0 | 0 | |
| CORIUM INTERNATIONAL INC | COM | 21887L107 | 50,921 | 6,357,133 | SH | SOLE | 0 | 6,357,133 | 0 | 0 | |
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 36,808 | 2,742,821 | SH | SOLE | 0 | 2,742,821 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 43,930 | 1,921,715 | SH | SOLE | 0 | 1,921,715 | 0 | 0 | |
| DBV TECHNOLOGIES SA SHS SPONSORED AMERICAN DEPOSIT | ADR | 23306J101 | 40,667 | 2,108,198 | SH | SOLE | 0 | 2,108,198 | 0 | 0 | |
| DOVA PHARMACEUTICALS INC | COM | 25985T102 | 93,525 | 3,125,851 | SH | SOLE | 0 | 3,125,851 | 0 | 0 | |
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 13,971 | 686,922 | SH | SOLE | 0 | 686,922 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,923 | 157,679 | SH | SOLE | 0 | 157,679 | 0 | 0 | |
| ELLOX PHARMACEUTICALS INC | COM | 29014R103 | 50 | 2,961 | SH | SOLE | 0 | 2,961 | 0 | 0 | |
| ENDOCYTE INC | COM | 29269A102 | 26,519 | 1,921,700 | SH | SOLE | 0 | 1,921,700 | 0 | 0 | |
| EVOLENT HEALTH INC | CL A | 30050B101 | 1,474 | 70,000 | SH | SOLE | 0 | 70,000 | 0 | 0 | |
| FERRARI N.V. | COM | N3167Y103 | 837 | 6,200 | SH | SOLE | 0 | 6,200 | 0 | 0 | |
| FIAT CHRYSLER AUTOMOBILES N. | SHS | N31738102 | 1,171 | 62,000 | SH | SOLE | 0 | 62,000 | 0 | 0 | |
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 7,962 | 307,989 | SH | SOLE | 0 | 307,989 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 5,598 | 1,117,324 | SH | SOLE | 0 | 1,117,324 | 0 | 0 | |
| G1 THERAPEUTICS INC | COM | 3621LQ109 | 611 | 14,055 | SH | SOLE | 0 | 14,055 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 13,908 | 150,875 | SH | SOLE | 0 | 150,875 | 0 | 0 | |
| GERON CORP | COM | 374163103 | 2,887 | 2,350,000 | SH | SOLE | 0 | 2,350,000 | 0 | 0 | |
| GERON CORP | COM | 374163103 | 35 | 200,000 | SH | SOLE | 0 | 200,000 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 218,266 | 4,828,910 | SH | SOLE | 0 | 4,828,910 | 0 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 22,988 | 1,501,501 | SH | SOLE | 0 | 1,501,501 | 0 | 0 | |
| HISTOGENICS CORP | COM | 43358V109 | 5,508 | 2,203,277 | SH | SOLE | 0 | 2,203,277 | 0 | 0 | |
| HUMANA INC | COM | 444859102 | 44,114 | 148,218 | SH | SOLE | 0 | 148,218 | 0 | 0 | |
| HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 301 | 10,000 | SH | SOLE | 0 | 10,000 | 0 | 0 | |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 47,848 | 100,000 | SH | SOLE | 0 | 100,000 | 0 | 0 | |
| INVACARE CORP | COM | 461203101 | 3,720 | 200,000 | SH | SOLE | 0 | 200,000 | 0 | 0 | |
| INVITAE CORP | COM | 46185L103 | 14,855 | 2,021,100 | SH | SOLE | 0 | 2,021,100 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 74,908 | 5,852,202 | SH | SOLE | 0 | 5,852,202 | 0 | 0 | |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 24,989 | 308,006 | SH | SOLE | 0 | 308,006 | 0 | 0 | |
| KADMON HLDGS INC | COM | 48283N106 | 52,531 | 13,165,746 | SH | SOLE | 0 | 13,165,746 | 0 | 0 | |
| KINIKSA PHARMACEUTICALS LTD | COM | G5269C101 | 1,928 | 111,111 | SH | SOLE | 0 | 111,111 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 125,828 | 4,313,611 | SH | SOLE | 0 | 4,313,611 | 0 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 653 | 3,765 | SH | SOLE | 0 | 3,765 | 0 | 0 | |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 9,010 | 32,213 | SH | SOLE | 0 | 32,213 | 0 | 0 | |
| MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 6,417 | 907,732 | SH | SOLE | 0 | 907,732 | 0 | 0 | |
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 53,900 | 4,703,398 | SH | SOLE | 0 | 4,703,398 | 0 | 0 | |
| MENLO THERAPEUTICS INC | COM | 586858102 | 10,079 | 1,241,287 | SH | SOLE | 0 | 1,241,287 | 0 | 0 | |
| MERIT MED SYS INC | COM | 589889104 | 55,399 | 1,082,013 | SH | SOLE | 0 | 1,082,013 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 35,160 | 713,191 | SH | SOLE | 0 | 713,191 | 0 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 3,787 | 724,133 | SH | SOLE | 0 | 724,133 | 0 | 0 | |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 501 | 24,489 | SH | SOLE | 0 | 24,489 | 0 | 0 | |
| MOTUS GI HLDGS INC | COM | 62014P108 | 20,207 | 2,810,542 | SH | SOLE | 0 | 2,810,542 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 54,078 | 1,089,169 | SH | SOLE | 0 | 1,089,169 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 296 | 6,057 | SH | SOLE | 0 | 6,057 | 0 | 0 | |
| NEPTUNE TECHNOLOGIES AND BIORESO | COM | 64077P108 | 20,379 | 8,574,015 | SH | SOLE | 0 | 8,574,015 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 463,226 | 4,715,250 | SH | SOLE | 0 | 4,715,250 | 0 | 0 | |
| NEURONETICS INC | COM | 64131A105 | 3,340 | 125,500 | SH | SOLE | 0 | 125,500 | 0 | 0 | |
| NUVECTRA CORP | COM | 67075N108 | 3,274 | 159,466 | SH | SOLE | 0 | 159,466 | 0 | 0 | |
| ODONATE THERAPEUTICS INC | COM | 676079106 | 3,312 | 150,000 | SH | SOLE | 0 | 150,000 | 0 | 0 | |
| ONCOMED PHARMACEUTICALS | COM | 68234X102 | 6,054 | 2,620,897 | SH | SOLE | 0 | 2,620,897 | 0 | 0 | |
| ONCOSEC MED INC | COM | 68234L207 | 69 | 50,000 | SH | SOLE | 0 | 50,000 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DBVC 4.250% 4/0 | 71426VAK4 | 426 | 1,000,000 | PRN | SOLE | 0 | 1,000,000 | 0 | 0 | |
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 819 | 334,116 | SH | SOLE | 0 | 334,116 | 0 | 0 | |
| PTC THERAPEUTICS INC | COM | 69366J200 | 653 | 19,367 | SH | SOLE | 0 | 19,367 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 187 | 100,000 | SH | SOLE | 0 | 100,000 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 27,480 | 464,579 | SH | SOLE | 0 | 464,579 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 52,058 | 6,483,020 | SH | SOLE | 0 | 6,483,020 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 62,215 | 867,106 | SH | SOLE | 0 | 867,106 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 57,387 | 3,212,871 | SH | SOLE | 0 | 3,212,871 | 0 | 0 | |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 25,029 | 800,686 | SH | SOLE | 0 | 800,686 | 0 | 0 | |
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 355 | 25,000 | SH | SOLE | 0 | 25,000 | 0 | 0 | |
| SENSEONICS HLDGS INC | COM | 81727U105 | 473 | 115,000 | SH | SOLE | 0 | 115,000 | 0 | 0 | |
| SIERRA ONCOLOGY INC | COM | 82640U107 | 13,320 | 4,500,000 | SH | SOLE | 0 | 4,500,000 | 0 | 0 | |
| SOLID BIOSCIENCES INC | COM | 3422E1055 | 139,927 | 3,927,222 | SH | SOLE | 0 | 3,927,222 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | COM | G85347105 | 1,650 | 275,000 | SH | SOLE | 0 | 275,000 | 0 | 0 | |
| SYNLOGIC INC | COM | 87166L100 | 9,268 | 942,852 | SH | SOLE | 0 | 942,852 | 0 | 0 | |
| TABULA RASA HEALTHCARE INC | COM | 873379101 | 936 | 14,663 | SH | SOLE | 0 | 14,663 | 0 | 0 | |
| TELADOC INC | COM | 87918A105 | 11,320 | 195,000 | SH | SOLE | 0 | 195,000 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 4,447 | 100,000 | SH | SOLE | 0 | 100,000 | 0 | 0 | |
| TG THERAPEUTICS INC | COM | 88322Q108 | 258 | 100,000 | SH | SOLE | 0 | 100,000 | 0 | 0 | |
| TRANSLATE BIO INC | COM | 89374L104 | 6,325 | 500,000 | SH | SOLE | 0 | 500,000 | 0 | 0 | |
| UNIQURE NV | SHS | N90064101 | 54,607 | 1,444,628 | SH | SOLE | 0 | 1,444,628 | 0 | 0 | |
| VBI VACCINES INC | COM NEW | 91822J103 | 26,581 | 9,665,843 | SH | SOLE | 0 | 9,665,843 | 0 | 0 | |
| VERICEL CORP | COM | 92346J108 | 264 | 27,211 | SH | SOLE | 0 | 27,211 | 0 | 0 | |
| VERONA PHARMA PLC | SPONSORED ADR | 925050106 | 307 | 22,327 | SH | SOLE | 0 | 22,327 | 0 | 0 | |
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 67,287 | 3,410,412 | SH | SOLE | 0 | 3,410,412 | 0 | 0 | |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 12,900 | 75,898 | SH | SOLE | 0 | 75,898 | 0 | 0 | |
| VICAL INC | COM NEW | 925602203 | 1,314 | 1,142,858 | SH | SOLE | 0 | 1,142,858 | 0 | 0 | |
| VIEWRAY INC | COM | 92672L107 | 519 | 75,000 | SH | SOLE | 0 | 75,000 | 0 | 0 | |
| VITAL THERAPIES INC | COM | 92847R104 | 405 | 150,000 | SH | SOLE | 0 | 150,000 | 0 | 0 | |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 10,817 | 282,798 | SH | SOLE | 0 | 282,798 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 39,530 | 1,068,095 | SH | SOLE | 0 | 1,068,095 | 0 | 0 | |
| XERIS PHARMACEUTICALS INC | COM | 98422L107 | 8,541 | 450,000 | SH | SOLE | 0 | 450,000 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L204 | 175,489 | 3,970,357 | SH | SOLE | 0 | 3,970,357 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 15,920 | 1,123,890 | SH | SOLE | 0 | 1,123,890 | 0 | 0 | |