The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | W EXP12/24/201 | 00289Y115 | 1,267 | 659,636 | SH | SOLE | 659,636 | 0 | 0 | ||
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 1,269 | 180,797 | SH | SOLE | 180,797 | 0 | 0 | ||
| ACASTI PHARMA INC | CL A NEW | 00430K402 | 1,480 | 1,779,882 | SH | SOLE | 1,779,882 | 0 | 0 | ||
| ACCELERON PHARMA INC | COM | 00434H108 | 39,938 | 905,017 | SH | SOLE | 905,017 | 0 | 0 | ||
| ADMA BIOLOGICS INC | COM | 000899104 | 14,542 | 6,521,102 | SH | SOLE | 6,521,102 | 0 | 0 | ||
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 960 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 9,182 | 1,703,440 | SH | SOLE | 1,703,440 | 0 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 39,506 | 1,704,330 | SH | SOLE | 1,704,330 | 0 | 0 | ||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 24,684 | 3,085,458 | SH | SOLE | 3,085,458 | 0 | 0 | ||
| ALLENA PHARMACEUTICALS INC | COM | 018119107 | 704 | 132,300 | SH | SOLE | 132,300 | 0 | 0 | ||
| ALLIQUA BIOMEDICAL INC | COM PAR | 019621309 | 214 | 114,730 | SH | SOLE | 114,730 | 0 | 0 | ||
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | 41,574 | 1,543,790 | SH | SOLE | 1,543,790 | 0 | 0 | ||
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 18,462 | 262,241 | SH | SOLE | 262,241 | 0 | 0 | ||
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 64,553 | 4,875,600 | SH | SOLE | 4,875,600 | 0 | 0 | ||
| AMEDISYS INC | COM | 023436108 | 422 | 3,672 | SH | SOLE | 3,672 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 191,701 | 20,724,424 | SH | SOLE | 20,724,424 | 0 | 0 | ||
| ANI PHARMACEUTICALS INC | NOTE 3.000%12/0 | 00182CAA1 | 7,383 | 7,500,000 | PRN | SOLE | 7,500,000 | 0 | 0 | ||
| AQUESTIVE THERAPEUTICS INC | COM | 3843E1047 | 13,314 | 2,113,400 | SH | SOLE | 2,113,400 | 0 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 55,605 | 1,430,171 | SH | SOLE | 1,430,171 | 0 | 0 | ||
| ARGENX SE | SPONSORED ADR | 04016X101 | 53,889 | 560,941 | SH | SOLE | 560,941 | 0 | 0 | ||
| ARROWHEAD PHARMACEUTICALS INC | COM | 04280A100 | 3,582 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 63,043 | 1,052,647 | SH | SOLE | 1,052,647 | 0 | 0 | ||
| ATHENEX INC | COM | 04685N103 | 32,550 | 5,096,022 | SH | SOLE | 5,096,022 | 0 | 0 | ||
| AXONICS MODULATION TECH INC | COM | 05465P101 | 10,935 | 751,000 | SH | SOLE | 751,000 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 43,484 | 857,326 | SH | SOLE | 857,326 | 0 | 0 | ||
| CAREDX INC | COM | 14167L103 | 1,037 | 44,128 | SH | SOLE | 44,128 | 0 | 0 | ||
| CLEMENTIA PHARMACEUTICALS INC | COM | 185575107 | 17,640 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 7,374 | 445,000 | SH | SOLE | 445,000 | 0 | 0 | ||
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 22,823 | 1,873,779 | SH | SOLE | 1,873,779 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS INC | COM | 22663K107 | 77,612 | 2,587,953 | SH | SOLE | 2,587,953 | 0 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 19,382 | 2,462,821 | SH | SOLE | 2,462,821 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 43,588 | 2,911,715 | SH | SOLE | 2,911,715 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 5,309 | 826,960 | SH | SOLE | 826,960 | 0 | 0 | ||
| DEXCOM INC | COM | 252131107 | 442 | 3,733 | SH | SOLE | 3,733 | 0 | 0 | ||
| DOVA PHARMACEUTICALS INC | COM | 25985T102 | 23,693 | 3,125,851 | SH | SOLE | 3,125,851 | 0 | 0 | ||
| EDIOS THERAPEUTICS INC | COM | 28249H104 | 9,452 | 686,922 | SH | SOLE | 686,922 | 0 | 0 | ||
| EHEALTH INC | COM | 28238P109 | 2,113 | 55,021 | SH | SOLE | 55,021 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,421 | 139,890 | SH | SOLE | 139,890 | 0 | 0 | ||
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 | 15,878 | 614,242 | SH | SOLE | 614,242 | 0 | 0 | ||
| FERRARI N.V. | COM | N3167Y103 | 610 | 6,200 | SH | SOLE | 6,200 | 0 | 0 | ||
| FIAT CHRYSLER AUTOMOBILES N. | SHS | N31738102 | 894 | 62,000 | SH | SOLE | 62,000 | 0 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 15,850 | 4,661,824 | SH | SOLE | 4,661,824 | 0 | 0 | ||
| GLAUKOS CORP | COM | 377322102 | 417 | 7,466 | SH | SOLE | 7,466 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 222,726 | 5,425,726 | SH | SOLE | 5,425,726 | 0 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 10,500 | 700,000 | SH | SOLE | 700,000 | 0 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 308 | 200,000 | SH | Call | SOLE | 200,000 | 0 | 0 | |
| INVACARE CORP | COM | 461203101 | 860 | 200,000 | SH | SOLE | 200,000 | 0 | 0 | ||
| INVITAE CORP | COM | 46185L103 | 20,609 | 1,863,406 | SH | SOLE | 1,863,406 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 108,333 | 12,241,111 | SH | SOLE | 12,241,111 | 0 | 0 | ||
| KADMON HLDGS INC | COM | 48283N106 | 27,384 | 13,165,746 | SH | SOLE | 13,165,746 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 22,259 | 3,135,199 | SH | SOLE | 3,135,199 | 0 | 0 | ||
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 41,022 | 4,313,611 | SH | SOLE | 4,313,611 | 0 | 0 | ||
| MARKER THERAPEUTICS INC | COM | 57055L107 | 11,100 | 2,000,000 | SH | SOLE | 2,000,000 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 11,617 | 4,400,440 | SH | SOLE | 4,400,440 | 0 | 0 | ||
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 45,340 | 4,703,398 | SH | SOLE | 4,703,398 | 0 | 0 | ||
| MERIT MEDICAL SYSTEMS INC | COM | 589889104 | 52,177 | 949,198 | SH | SOLE | 949,198 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 5,250 | 125,875 | SH | SOLE | 125,875 | 0 | 0 | ||
| MOLECULAR TEMPLATES INC | COM | 608550109 | 7,107 | 1,974,133 | SH | SOLE | 1,974,133 | 0 | 0 | ||
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 31,132 | 2,825,000 | SH | SOLE | 2,825,000 | 0 | 0 | ||
| MOTUS GI HOLDINGS INC | COM | 62014P108 | 9,984 | 3,210,542 | SH | SOLE | 3,210,542 | 0 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 53,503 | 1,075,216 | SH | SOLE | 1,075,216 | 0 | 0 | ||
| NEPTUNE WELLNESS SOLUTIONS I | COM | 64079L105 | 17,849 | 8,891,452 | SH | SOLE | 8,891,452 | 0 | 0 | ||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 315,363 | 4,608,554 | SH | SOLE | 4,608,554 | 0 | 0 | ||
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 1,284 | 1,719,111 | SH | SOLE | 1,719,111 | 0 | 0 | ||
| ONCOSEC MEDICAL INC | COM | 68234L207 | 32 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 8,207 | 521,800 | SH | SOLE | 521,800 | 0 | 0 | ||
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/201 | 69012T115 | 72 | 420,875 | SH | SOLE | 420,875 | 0 | 0 | ||
| PENUMBRA INC | COM | 70975L107 | 2,037 | 16,338 | SH | SOLE | 16,338 | 0 | 0 | ||
| PERNIX THERAPEUTICS HLDGS IN | DBCV 4,250% 4/0 | 71426VAK4 | 642 | 1,000,000 | PRN | SOLE | 1,000,000 | 0 | 0 | ||
| PROQR THERAPEUTICS N.V. | SHS EURO | N71542109 | 11,250 | 722,523 | SH | SOLE | 722,523 | 0 | 0 | ||
| PROTAGONIST THERAPEUTICS INC | COM | 4366E1029 | 9,190 | 1,365,579 | SH | SOLE | 1,365,579 | 0 | 0 | ||
| QUOTIENT LTD | COM | G73268107 | 66,029 | 10,789,054 | SH | SOLE | 10,789,054 | 0 | 0 | ||
| REGENXBIO INC | COM | 75901B107 | 26,894 | 645,726 | SH | SOLE | 645,726 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 49,782 | 3,342,038 | SH | SOLE | 3,342,038 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 13,763 | 509,186 | SH | SOLE | 509,186 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 3,495 | 240,173 | SH | SOLE | 240,173 | 0 | 0 | ||
| SAGE THERAPEUTICS INC | COM | 78667J108 | 13,110 | 147,315 | SH | SOLE | 147,315 | 0 | 0 | ||
| SI-BONE INC | COM | 825704109 | 307 | 15,000 | SH | SOLE | 15,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 3,413 | 2,666,190 | SH | SOLE | 2,666,190 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 83422E105 | 14 | 1,835 | SH | Call | SOLE | 1,835 | 0 | 0 | |
| SOLID BIOSCIENCES INC | COM | 83422E105 | 105,249 | 3,927,222 | SH | SOLE | 3,927,222 | 0 | 0 | ||
| STAAR SURGICAL CO | COM PAR $ 0.01 | 852312305 | 405 | 12,953 | SH | SOLE | 12,953 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 6,049 | 867,852 | SH | SOLE | 867,852 | 0 | 0 | ||
| TANDEM DIABETES CARE INC | COM NEW | 875372203 | 479 | 12,844 | SH | SOLE | 12,844 | 0 | 0 | ||
| TELADOC HEALTH INC | COM | 87918A105 | 2,974 | 60,000 | SH | SOLE | 60,000 | 0 | 0 | ||
| THERAPEUTICSMD INC | COM | 88338N107 | 5,715 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| TRANSLATE BIO INC | COM | 89374L104 | 3,167 | 435,000 | SH | SOLE | 435,000 | 0 | 0 | ||
| UNIQURE NV | SHS | N90064101 | 5,946 | 220,707 | SH | SOLE | 220,707 | 0 | 0 | ||
| UROVANT SCIENCES LTD | SHS | G9381B108 | 3,915 | 625,359 | SH | SOLE | 625,359 | 0 | 0 | ||
| VACCINEX INC | COM | 918640103 | 190 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| VAPOTHERM INC | COM | 922107107 | 24,464 | 1,226,315 | SH | SOLE | 1,226,315 | 0 | 0 | ||
| VBI VACCINES INC | COM NEW | 91822J103 | 38,322 | 23,951,556 | SH | SOLE | 23,951,556 | 0 | 0 | ||
| VERICEL CORP | COM | 92346J108 | 488 | 28,090 | SH | SOLE | 28,090 | 0 | 0 | ||
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 27,794 | 3,410,412 | SH | SOLE | 3,410,412 | 0 | 0 | ||
| VERU INC | COM | 92536C103 | 1,853 | 1,425,000 | SH | SOLE | 1,425,000 | 0 | 0 | ||
| VIEWRAY INC | COM | 92672L107 | 21,715 | 3,905,650 | SH | SOLE | 3,905,650 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 2,501 | 59,498 | SH | SOLE | 59,498 | 0 | 0 | ||
| XENCOR INC | COM | 98401F105 | 6,833 | 196,810 | SH | SOLE | 196,810 | 0 | 0 | ||
| ZOGENIX INC | COM | 98978L204 | 138,191 | 3,790,216 | SH | SOLE | 3,790,216 | 0 | 0 | ||
| ZOGENIX INC | COM | 98978L204 | 410 | 200,000 | SH | Put | SOLE | 200,000 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 7,196 | 573,890 | SH | SOLE | 573,890 | 0 | 0 | ||