The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CLASS A COM | 88025U109 | 16,775 | 220,000 | SH | SOLE | 220,000 | 0 | 0 | ||
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 4,905 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 482 | 11,256 | SH | SOLE | 11,256 | 0 | 0 | ||
| ACASTI PHARMA INC | COM | 00430K402 | 4,361 | 1,779,882 | SH | SOLE | 1,779,882 | 0 | 0 | ||
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 9,126 | 305,000 | SH | SOLE | 305,000 | 0 | 0 | ||
| ADMA BIOLOGICS INC | COM | 000899104 | 46,084 | 11,521,102 | SH | SOLE | 11,521,102 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 29,799 | 11,919,925 | SH | SOLE | 11,919,925 | 0 | 0 | ||
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 42,975 | 900,000 | SH | SOLE | 900,000 | 0 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 43,324 | 1,704,330 | SH | SOLE | 1,704,330 | 0 | 0 | ||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 17,926 | 3,085,458 | SH | SOLE | 3,085,458 | 0 | 0 | ||
| ALECTOR INC | COM | 014442107 | 8,817 | 511,731 | SH | SOLE | 511,731 | 0 | 0 | ||
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | 40,107 | 1,543,790 | SH | SOLE | 1,543,790 | 0 | 0 | ||
| ALPHATEC HOLDINGS INC | COM | 02081G201 | 3,984 | 561,574 | SH | SOLE | 561,574 | 0 | 0 | ||
| AMARIN CORPORATION PLC | SPONS ADR NEW | 023111206 | 152,355 | 7,106,079 | SH | SOLE | 7,106,079 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 244,789 | 25,132,364 | SH | SOLE | 25,132,364 | 0 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 16,250 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| AQUESTIVE THERAPEUTICS INC | COM | 3843E1047 | 13,095 | 2,250,000 | SH | SOLE | 2,250,000 | 0 | 0 | ||
| ARAVIVE INC | COM | 03890D108 | 450 | 32,895 | SH | SOLE | 32,895 | 0 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM | 040047607 | 43,291 | 953,129 | SH | SOLE | 953,129 | 0 | 0 | ||
| ARROWHEAD PHARMACEUTICALS INC | COM | 04280A100 | 1,950 | 30,738 | SH | SOLE | 30,738 | 0 | 0 | ||
| ARVINAS INC | COM | 04335A105 | 16,436 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| ATHENEX INC | COM | 04685N103 | 176,100 | 11,532,467 | SH | SOLE | 11,532,467 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 14,520 | 716,666 | SH | SOLE | 716,666 | 0 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 66 | 8,681 | SH | SOLE | 8,681 | 0 | 0 | ||
| AXONICS MODULATION TECH INC | COM | 05465P101 | 1,524 | 55,000 | SH | SOLE | 55,000 | 0 | 0 | ||
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 4 | 200,000 | SH | Put | SOLE | 200,000 | 0 | 0 | |
| BIO-RAD LABORATORIES INC | CL A | 090572207 | 25,343 | 68,489 | SH | SOLE | 68,489 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 49,558 | 618,624 | SH | SOLE | 618,624 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 142,273 | 6,706,268 | SH | SOLE | 6,706,268 | 0 | 0 | ||
| CERNER CORP | COM | 156782104 | 7,706 | 105,000 | SH | SOLE | 105,000 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 8,670 | 421,272 | SH | SOLE | 421,272 | 0 | 0 | ||
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 19,840 | 2,150,641 | SH | SOLE | 2,150,641 | 0 | 0 | ||
| CONSTELLATION PHARMCETICLS INC | COM | 210373106 | 283 | 6,000 | SH | SOLE | 6,000 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS INC | COM | 22663K107 | 64,931 | 2,587,953 | SH | SOLE | 2,587,953 | 0 | 0 | ||
| CRYOLIFE INC | COM | 228903100 | 1,355 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 27,040 | 3,253,923 | SH | SOLE | 3,253,923 | 0 | 0 | ||
| DBV TECHNOLOGIES SA | SPONSORED ADR | 23306J101 | 46,735 | 4,367,809 | SH | SOLE | 4,367,809 | 0 | 0 | ||
| DECIPHERA PHARMACEUTICALS INC | COM | 24344T101 | 892 | 14,326 | SH | SOLE | 14,326 | 0 | 0 | ||
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 804 | 36,496 | SH | SOLE | 36,496 | 0 | 0 | ||
| EHEALTH INC | COM | 28238P109 | 18,997 | 197,720 | SH | SOLE | 197,720 | 0 | 0 | ||
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 40,030 | 697,524 | SH | SOLE | 697,524 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 2,084 | 139,890 | SH | SOLE | 139,890 | 0 | 0 | ||
| ESTABLISHMENT LABS HOLDINGS INC | COM | G31249108 | 29,057 | 1,050,528 | SH | SOLE | 1,050,528 | 0 | 0 | ||
| FERRARI N.V. | COM | N3167Y103 | 1,026 | 6,200 | SH | SOLE | 6,200 | 0 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | COM | M46135105 | 37,309 | 11,203,881 | SH | SOLE | 11,203,881 | 0 | 0 | ||
| FREQUENCY THERAPEUTICS INC | COM | 35803L108 | 49,812 | 3,034,296 | SH | SOLE | 3,034,296 | 0 | 0 | ||
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 9,984 | 600,000 | SH | SOLE | 600,000 | 0 | 0 | ||
| GALERA THERAPEUTICS INC | COM | 36338D108 | 4,277 | 325,000 | SH | SOLE | 325,000 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 466,266 | 5,865,726 | SH | SOLE | 5,865,726 | 0 | 0 | ||
| HEALTH CATALYST INC | COM | 42225T107 | 9,844 | 283,698 | SH | SOLE | 283,698 | 0 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 8,561 | 1,141,484 | SH | SOLE | 1,141,484 | 0 | 0 | ||
| IMMUNOVANT INC | UNIT 12/18/2024 | 45258J201 | 9,948 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| INTERCEPT PHARMACEUTICALS INC | COM | 45845P108 | 12,095 | 97,600 | SH | SOLE | 97,600 | 0 | 0 | ||
| INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 28,575 | 800,600 | SH | Call | SOLE | 800,600 | 0 | 0 | |
| INVITAE CORP | COM | 46185L103 | 5,425 | 336,308 | SH | SOLE | 336,308 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 260,640 | 9,416,202 | SH | SOLE | 9,416,202 | 0 | 0 | ||
| IVERIC BIO INC | COM | 46583P102 | 8,497 | 990,289 | SH | SOLE | 990,289 | 0 | 0 | ||
| KADMON HOLDINGS INC | COM | 48283N106 | 66,302 | 14,636,334 | SH | SOLE | 14,636,334 | 0 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 523 | 6,944 | SH | SOLE | 6,944 | 0 | 0 | ||
| KARYOPHARM THERAPEUTICS INC | COM | 48576U106 | 1,048 | 54,645 | SH | SOLE | 54,645 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 263,593 | 3,663,557 | SH | SOLE | 3,663,557 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 552996456 | 10,913 | 4,400,440 | SH | SOLE | 4,400,440 | 0 | 0 | ||
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 128,794 | 6,433,277 | SH | SOLE | 6,433,277 | 0 | 0 | ||
| MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 588 | 179,419 | SH | SOLE | 179,419 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 412,791 | 3,203,406 | SH | SOLE | 3,203,406 | 0 | 0 | ||
| MOLECULAR TEMPLATES INC | COM | 608550109 | 34,601 | 2,474,133 | SH | SOLE | 2,474,133 | 0 | 0 | ||
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 55,947 | 2,835,637 | SH | SOLE | 2,835,637 | 0 | 0 | ||
| MORPHIC HOLDING INC | COM | 61775R105 | 11,154 | 650,000 | SH | SOLE | 650,000 | 0 | 0 | ||
| MOTUS GI HLDGS INC | COM | 62014P108 | 9,642 | 4,210,542 | SH | SOLE | 4,210,542 | 0 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 87,929 | 1,206,411 | SH | SOLE | 1,206,411 | 0 | 0 | ||
| NATERA INC | COM | 632307104 | 490 | 14,549 | SH | SOLE | 14,549 | 0 | 0 | ||
| NEOLEUKIN THERAPEUTICS INC | COM | 64049K104 | 6,160 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| NEPTUNE WELLNESS SOLUTIONS INC | COM | 64079L105 | 36,752 | 13,436,906 | SH | SOLE | 13,436,906 | 0 | 0 | ||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 388,313 | 3,612,554 | SH | SOLE | 3,612,554 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 89,787 | 763,886 | SH | SOLE | 763,886 | 0 | 0 | ||
| NOVOCURE LTD | COM | G6674U108 | 800 | 9,489 | SH | SOLE | 9,489 | 0 | 0 | ||
| OPTINOSE INC | COM | 68404V100 | 535 | 58,005 | SH | SOLE | 58,005 | 0 | 0 | ||
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 33 | 420,875 | SH | SOLE | 420,875 | 0 | 0 | ||
| PHREESIA INC | COM | 71944F106 | 1,865 | 70,000 | SH | SOLE | 70,000 | 0 | 0 | ||
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 140 | 341,743 | SH | SOLE | 341,743 | 0 | 0 | ||
| PROVENTION BIO INC | COM | 74374N102 | 43,532 | 2,921,574 | SH | SOLE | 2,921,574 | 0 | 0 | ||
| QUOTIENT LTD | COM | G73268107 | 126,378 | 13,289,054 | SH | SOLE | 13,289,054 | 0 | 0 | ||
| REGENXBIO INC | COM | 75901B107 | 24,910 | 608,000 | SH | SOLE | 608,000 | 0 | 0 | ||
| REPRO MED SYS INC | COM | 759910102 | 489 | 74,813 | SH | SOLE | 74,813 | 0 | 0 | ||
| RESTORBIO INC | COM | 76133L103 | 14 | 9,306 | SH | SOLE | 9,306 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 41,046 | 2,890,608 | SH | SOLE | 2,890,608 | 0 | 0 | ||
| REVANCE THERAPEUTICS INC | COM | 761330109 | 13,315 | 820,377 | SH | SOLE | 820,377 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 3,922 | 170,859 | SH | SOLE | 170,859 | 0 | 0 | ||
| ROCKET PHARMACUETICALS INC | COM | 77313F106 | 50,965 | 2,239,241 | SH | SOLE | 2,239,241 | 0 | 0 | ||
| SC HEALTH CORP | UNIT 99/99/9999 | G78516302 | 10,360 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| SELECT INTERIOR CONCEPTS INC | COM | 816120307 | 945 | 105,105 | SH | SOLE | 105,105 | 0 | 0 | ||
| SHOCKWAVE MED INC | COM | 82489T104 | 1,318 | 30,000 | SH | SOLE | 30,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 910 | 2,666,190 | SH | SOLE | 2,666,190 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 3422E1055 | 30,036 | 6,749,803 | SH | SOLE | 6,749,803 | 0 | 0 | ||
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 1,558 | 1,000,000 | SH | Put | SOLE | 1,000,000 | 0 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 128,461 | 3,337,522 | SH | SOLE | 3,337,522 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 19,030 | 671,978 | SH | SOLE | 671,978 | 0 | 0 | ||
| TANDEM DIABETES CARE INC | COM | 875372203 | 18,479 | 310,000 | SH | SOLE | 310,000 | 0 | 0 | ||
| THERAPEUTICSMD INC | COM | 88338N107 | 2,653 | 1,096,101 | SH | SOLE | 1,096,101 | 0 | 0 | ||
| TRANSLATE BIO INC | COM | 89374L104 | 3,541 | 435,000 | SH | SOLE | 435,000 | 0 | 0 | ||
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 27,245 | 437,390 | SH | SOLE | 437,390 | 0 | 0 | ||
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 4,533 | 215,856 | SH | SOLE | 215,856 | 0 | 0 | ||
| UROVANT SCIENCES LTD | COM | G9381B108 | 37,331 | 2,406,931 | SH | SOLE | 2,406,931 | 0 | 0 | ||
| VAPOTHERM INC | COM | 922107107 | 21,204 | 1,743,767 | SH | SOLE | 1,743,767 | 0 | 0 | ||
| VBI VACCINES INC | COM | 91822J103 | 63,413 | 45,951,556 | SH | SOLE | 45,951,556 | 0 | 0 | ||
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 52,022 | 3,410,412 | SH | SOLE | 3,410,412 | 0 | 0 | ||
| VERU INC | COM | 92536C103 | 5,528 | 1,650,000 | SH | SOLE | 1,650,000 | 0 | 0 | ||
| VIEWRAY INC | COM | 92672L107 | 10,346 | 2,451,748 | SH | SOLE | 2,451,748 | 0 | 0 | ||
| VOCERA COMMUNICATIONS INC | COM | 92857F107 | 6,154 | 296,420 | SH | SOLE | 296,420 | 0 | 0 | ||
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 17,570 | 562,237 | SH | SOLE | 562,237 | 0 | 0 | ||
| ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 7,484 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| ZOGENIX INC | COM | 98978L204 | 193,358 | 3,709,152 | SH | SOLE | 3,709,152 | 0 | 0 | ||
| ZYMEWORKS INC | COM | 98985W102 | 109,241 | 2,403,026 | SH | SOLE | 2,403,026 | 0 | 0 | ||
| ZYNERBA PHARMACEUTICALS INC | COM | 98986X109 | 790 | 200,000 | SH | Put | SOLE | 200,000 | 0 | 0 | |