The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CLASS A COM | 88025U109 | 13,816 | 220,000 | SH | SOLE | 220,000 | 0 | 0 | ||
| 1LIFE HEALTHCARE INC | COM | 68269G107 | 3,310 | 185,000 | SH | SOLE | 185,000 | 0 | 0 | ||
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 3,060 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| ACCELERON PHARMA INC | COM | 00434H108 | 583 | 6,813 | SH | SOLE | 6,813 | 0 | 0 | ||
| ADAPTIVE BIOTECHNOLOGIES CORP | COM | 00650F109 | 13,424 | 495,000 | SH | SOLE | 495,000 | 0 | 0 | ||
| ADMA BIOLOGICS INC | COM | 000899104 | 47,764 | 11,521,102 | SH | SOLE | 11,521,102 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 29,611 | 15,919,325 | SH | SOLE | 15,919,325 | 0 | 0 | ||
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 31,860 | 900,000 | SH | SOLE | 900,000 | 0 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 31,931 | 1,960,139 | SH | SOLE | 1,960,139 | 0 | 0 | ||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 7,621 | 3,085,458 | SH | SOLE | 3,085,458 | 0 | 0 | ||
| ALECTOR INC | COM | 014442107 | 12,348 | 511,731 | SH | SOLE | 511,731 | 0 | 0 | ||
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | 30,011 | 1,543,790 | SH | SOLE | 1,543,790 | 0 | 0 | ||
| ALPHATEC HOLDINGS INC | COM | 02081G201 | 2,021 | 561,574 | SH | SOLE | 561,574 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 232,685 | 25,182,364 | SH | SOLE | 25,182,364 | 0 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 7,070 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 327 | 11,418 | SH | SOLE | 11,418 | 0 | 0 | ||
| AQUESTIVE THERAPEUTICS INC | COM | 3843E1047 | 3,833 | 1,750,000 | SH | SOLE | 1,750,000 | 0 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM | 040047607 | 28,356 | 675,129 | SH | SOLE | 675,129 | 0 | 0 | ||
| ARTARA THERAPEUTICS INC | COM | 04300J107 | 184 | 8,543 | SH | SOLE | 8,543 | 0 | 0 | ||
| ATHENEX INC | COM | 04685N103 | 89,261 | 11,532,467 | SH | SOLE | 11,532,467 | 0 | 0 | ||
| ATRICURE INC | COM | 04963C209 | 10,152 | 302,227 | SH | SOLE | 302,227 | 0 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | ADR | 05337M104 | 76 | 8,681 | SH | SOLE | 8,681 | 0 | 0 | ||
| AXONICS MODULATION TECHNOLOGIES INC | COM | 05465P101 | 1,188 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| BIO-RAD LABORATORIES INC | COM | 090572207 | 1,218 | 3,489 | SH | SOLE | 3,489 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 27,561 | 1,104,656 | SH | SOLE | 1,104,656 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 40,271 | 688,624 | SH | SOLE | 688,624 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 194,481 | 6,706,268 | SH | SOLE | 6,706,268 | 0 | 0 | ||
| CERNER CORP | COM | 156782104 | 6,745 | 105,000 | SH | SOLE | 105,000 | 0 | 0 | ||
| CHEMOCENTRYX INC | COM | 16383L106 | 406 | 10,252 | SH | SOLE | 10,252 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 25,339 | 1,551,722 | SH | SOLE | 1,551,722 | 0 | 0 | ||
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 19,549 | 2,150,641 | SH | SOLE | 2,150,641 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS INC | COM | 22663K107 | 38,042 | 2,587,953 | SH | SOLE | 2,587,953 | 0 | 0 | ||
| CUE BIOPHARMA INC | COM | 22978P106 | 362 | 26,371 | SH | SOLE | 26,371 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 24,958 | 3,253,923 | SH | SOLE | 3,253,923 | 0 | 0 | ||
| DBV TECHNOLOGIES SA | SPONSORED ADR | 23306J101 | 28,685 | 7,317,809 | SH | SOLE | 7,317,809 | 0 | 0 | ||
| DENALI THERAPEUTICS INC | COM | 24823R105 | 14,884 | 850,000 | SH | SOLE | 850,000 | 0 | 0 | ||
| DERMTECH INC | COM | 24984K105 | 3,215 | 285,856 | SH | SOLE | 285,856 | 0 | 0 | ||
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 33,652 | 686,922 | SH | SOLE | 686,922 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 951 | 139,890 | SH | SOLE | 139,890 | 0 | 0 | ||
| ESTABLISHMENT LABS HOLDINGS INC | COM | G31249108 | 13,332 | 922,633 | SH | SOLE | 922,633 | 0 | 0 | ||
| FERRARI N.V. | COM | N3167Y103 | 957 | 6,200 | SH | SOLE | 6,200 | 0 | 0 | ||
| FREQUENCY THERAPEUTICS INC | COM | 35803L108 | 54,040 | 3,034,296 | SH | SOLE | 3,034,296 | 0 | 0 | ||
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 7,164 | 600,000 | SH | SOLE | 600,000 | 0 | 0 | ||
| GALERA THERAPEUTICS INC | COM | 36338D108 | 3,088 | 325,000 | SH | SOLE | 325,000 | 0 | 0 | ||
| GILEAD SCIENCES INC | COM | 375558103 | 11,214 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 309,897 | 6,065,726 | SH | SOLE | 6,065,726 | 0 | 0 | ||
| HEALTH CATALYST INC | COM | 42225T107 | 8,375 | 328,698 | SH | SOLE | 328,698 | 0 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 4,702 | 1,141,484 | SH | SOLE | 1,141,484 | 0 | 0 | ||
| IMMUNOVANT INC | UNIT 12/18/2024 | 45258J201 | 7,356 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| INSULET CORP | COM | 45784P101 | 13,708 | 82,733 | SH | SOLE | 82,733 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 349,343 | 11,670,057 | SH | SOLE | 11,670,057 | 0 | 0 | ||
| IVERIC BIO INC | COM | 46583P102 | 4,738 | 1,377,289 | SH | SOLE | 1,377,289 | 0 | 0 | ||
| KADMON HOLDINGS INC | COM | 48283N106 | 65,830 | 15,711,334 | SH | SOLE | 15,711,334 | 0 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 497 | 6,944 | SH | SOLE | 6,944 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 174,752 | 3,663,557 | SH | SOLE | 3,663,557 | 0 | 0 | ||
| LEAP THERAPEUTICS INC | COM | 52187K101 | 10,627 | 6,726,496 | SH | SOLE | 6,726,496 | 0 | 0 | ||
| LIFESCI ACQUISITION CORP | UNIT 3/31/2025 | 53228P208 | 2,940 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| LUMINEX CORP | COM | 5027E1029 | 500 | 18,926 | SH | SOLE | 18,926 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 4,879 | 3,030,440 | SH | SOLE | 3,030,440 | 0 | 0 | ||
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 86,463 | 6,433,277 | SH | SOLE | 6,433,277 | 0 | 0 | ||
| MENLO THERAPEUTICS INC | COM | 586858102 | 17,456 | 6,637,179 | SH | SOLE | 6,637,179 | 0 | 0 | ||
| MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 187 | 179,419 | SH | SOLE | 179,419 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 149 | 100,000 | SH | Put | SOLE | 100,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 255,167 | 3,319,450 | SH | SOLE | 3,319,450 | 0 | 0 | ||
| MOLECULAR TEMPLATES INC | COM | 608550109 | 32,882 | 2,474,133 | SH | SOLE | 2,474,133 | 0 | 0 | ||
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 881 | 30,637 | SH | SOLE | 30,637 | 0 | 0 | ||
| MORPHIC HOLDING INC | COM | 61775R105 | 9,542 | 650,000 | SH | SOLE | 650,000 | 0 | 0 | ||
| MOTUS GI HLDGS INC | COM | 62014P108 | 2,837 | 4,210,542 | SH | SOLE | 4,210,542 | 0 | 0 | ||
| MYLAN N.V. | SHS EURO | N59465109 | 6,028 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 61,611 | 1,314,209 | SH | SOLE | 1,314,209 | 0 | 0 | ||
| NEOLEUKIN THERAPEUTICS INC | COM | 64049K104 | 5,535 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| NEPTUNE WELLNESS SOLUTIONS INC | COM | 64079L105 | 15,721 | 13,436,906 | SH | SOLE | 13,436,906 | 0 | 0 | ||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 265,126 | 3,063,263 | SH | SOLE | 3,063,263 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 107,449 | 1,092,068 | SH | SOLE | 1,092,068 | 0 | 0 | ||
| OUTLOOK THERAPEUTICS INC | W EXP 02/18/202 | 69012T115 | 46 | 420,875 | SH | SOLE | 420,875 | 0 | 0 | ||
| PHREESIA INC | COM | 71944F106 | 1,424 | 70,000 | SH | SOLE | 70,000 | 0 | 0 | ||
| PROVENTION BIO INC | COM | 74374N102 | 27,707 | 3,011,574 | SH | SOLE | 3,011,574 | 0 | 0 | ||
| QUOTIENT LTD | COM | G73268107 | 52,491 | 13,289,054 | SH | SOLE | 13,289,054 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS INC | COM | 75886F107 | 39,063 | 80,000 | SH | SOLE | 80,000 | 0 | 0 | ||
| REGENXBIO INC | COM | 75901B107 | 17,145 | 508,000 | SH | SOLE | 508,000 | 0 | 0 | ||
| REPRO MED SYS INC | COM | 759910102 | 537 | 74,813 | SH | SOLE | 74,813 | 0 | 0 | ||
| RESTORBIO INC | COM | 76133L103 | 10 | 9,306 | SH | SOLE | 9,306 | 0 | 0 | ||
| RETROPHIN INC | NOTE 2.500% 9/1 | 761299AB2 | 35,016 | 45,000,000 | PRN | SOLE | 45,000,000 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 42,173 | 2,890,608 | SH | SOLE | 2,890,608 | 0 | 0 | ||
| REVANCE THERAPEUTICS INC | COM | 761330109 | 13,690 | 925,000 | SH | SOLE | 925,000 | 0 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 7,816 | 350,000 | SH | SOLE | 350,000 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 2,600 | 170,859 | SH | SOLE | 170,859 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 30,537 | 2,189,010 | SH | SOLE | 2,189,010 | 0 | 0 | ||
| SC HEALTH CORP | UNIT 99/99/9999 | G78516302 | 10,000 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| SCHRODINGER INC | COM | 80810D103 | 10,545 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U404 | 664 | 66,654 | SH | SOLE | 66,654 | 0 | 0 | ||
| SILK ROAD MEDICAL INC | COM | 82710M100 | 6,639 | 204,600 | SH | SOLE | 204,600 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 3422E1055 | 16,132 | 6,749,803 | SH | SOLE | 6,749,803 | 0 | 0 | ||
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 159 | 325,000 | SH | Call | SOLE | 325,000 | 0 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 94,078 | 3,484,358 | SH | SOLE | 3,484,358 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 15,388 | 671,978 | SH | SOLE | 671,978 | 0 | 0 | ||
| THERAPEUTICSMD INC | COM | 88338N107 | 1,173 | 1,096,101 | SH | SOLE | 1,096,101 | 0 | 0 | ||
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 23,110 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| TRANSLATE BIO INC | COM | 89374L104 | 4,994 | 435,000 | SH | SOLE | 435,000 | 0 | 0 | ||
| TURNING POINT THERAPEUTICS INC | COM | 90041T108 | 15,441 | 349,890 | SH | SOLE | 349,890 | 0 | 0 | ||
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 10,380 | 322,356 | SH | SOLE | 322,356 | 0 | 0 | ||
| UROVANT SCIENCES LTD | COM | G9381B108 | 21,823 | 2,366,831 | SH | SOLE | 2,366,831 | 0 | 0 | ||
| VAPOTHERM INC | COM | 922107107 | 31,447 | 1,670,067 | SH | SOLE | 1,670,067 | 0 | 0 | ||
| VBI VACCINES INC | COM | 91822J103 | 43,653 | 45,951,556 | SH | SOLE | 45,951,556 | 0 | 0 | ||
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 37,275 | 3,410,412 | SH | SOLE | 3,410,412 | 0 | 0 | ||
| VERU INC REGISTERED SHS | COM | 92536C103 | 5,396 | 1,650,000 | SH | SOLE | 1,650,000 | 0 | 0 | ||
| VIEWRAY INC | COM | 92672L107 | 5,713 | 2,451,748 | SH | SOLE | 2,451,748 | 0 | 0 | ||
| VOCERA COMMUNICATIONS INC | COM | 92857F107 | 10,298 | 470,000 | SH | SOLE | 470,000 | 0 | 0 | ||
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 12,085 | 522,480 | SH | SOLE | 522,480 | 0 | 0 | ||
| ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 4,914 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| ZOGENIX INC | COM | 98978L204 | 85,390 | 3,452,921 | SH | SOLE | 3,452,921 | 0 | 0 | ||
| ZOGENIX INC | COM | 98978L204 | 724 | 300,000 | SH | Put | SOLE | 300,000 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 126,092 | 3,560,999 | SH | SOLE | 3,560,999 | 0 | 0 | ||