The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 1LIFE HEALTHCARE INC | COM | 68269G107 | 7,948 | 218,844 | SH | SOLE | 218,844 | 0 | 0 | ||
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 4,004 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 23,222 | 480,000 | SH | SOLE | 480,000 | 0 | 0 | ||
| ADMA BIOLOGICS INC | COM | 000899104 | 48,593 | 16,584,802 | SH | SOLE | 16,584,802 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 44,257 | 15,919,925 | SH | SOLE | 15,919,925 | 0 | 0 | ||
| AGIO PHARMACEUTICALS INC | COM | 00847X104 | 48,132 | 900,000 | SH | SOLE | 900,000 | 0 | 0 | ||
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 716 | 52,724 | SH | SOLE | 52,724 | 0 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 51,924 | 1,960,139 | SH | SOLE | 1,960,139 | 0 | 0 | ||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 12,866 | 3,085,458 | SH | SOLE | 3,085,458 | 0 | 0 | ||
| ALECTOR INC | COM | 014442107 | 12,507 | 511,731 | SH | SOLE | 511,731 | 0 | 0 | ||
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | 66,105 | 1,543,790 | SH | SOLE | 1,543,790 | 0 | 0 | ||
| ALPHATEC HLDGS INC | COM NEW | 02081G201 | 2,639 | 561,574 | SH | SOLE | 561,574 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 379,750 | 25,182,364 | SH | SOLE | 25,182,364 | 0 | 0 | ||
| AMYRIS INC | COM NEW | 03236M200 | 6,449 | 1,844,612 | SH | SOLE | 1,844,612 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 373 | 11,418 | SH | SOLE | 11,418 | 0 | 0 | ||
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 | 8,505 | 1,750,000 | SH | SOLE | 1,750,000 | 0 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 68,938 | 1,095,129 | SH | SOLE | 1,095,129 | 0 | 0 | ||
| ATHENEX INC | COM | 04685N103 | 155,935 | 11,532,467 | SH | SOLE | 11,532,467 | 0 | 0 | ||
| ATRICURE INC | COM | 04963C209 | 23,768 | 528,776 | SH | SOLE | 528,776 | 0 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 133 | 8,681 | SH | SOLE | 8,681 | 0 | 0 | ||
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 31,613 | 1,235,818 | SH | SOLE | 1,235,818 | 0 | 0 | ||
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 4,114 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 11,576 | 1,125,000 | SH | SOLE | 1,125,000 | 0 | 0 | ||
| BIO RAD LABS INC | CL A | 090572207 | 6,993 | 15,489 | SH | SOLE | 15,489 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 43,996 | 1,104,656 | SH | SOLE | 1,104,656 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 53,713 | 688,624 | SH | SOLE | 688,624 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 218,691 | 6,706,268 | SH | SOLE | 6,706,268 | 0 | 0 | ||
| BURNING ROCK BIOTECH LTD | SPONSORED ADS | 12233L107 | 4,052 | 150,000 | SH | SOLE | 150,000 | 0 | 0 | ||
| CHEMOCENTRYX INC | COM | 16383L106 | 590 | 10,252 | SH | SOLE | 10,252 | 0 | 0 | ||
| COHERUS BIOSCIENCES INC | COM | 19249H103 | 9,739 | 545,285 | SH | SOLE | 545,285 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 36,016 | 2,058,068 | SH | SOLE | 2,058,068 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | NOTE 2.625% 2/1 | 19459JAA2 | 157,227 | 17,500,000 | PRN | SOLE | 17,500,000 | 0 | 0 | ||
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 21,398 | 2,150,641 | SH | SOLE | 2,150,641 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 59,171 | 3,659,381 | SH | SOLE | 3,659,381 | 0 | 0 | ||
| CUE BIOPHARMA INC | COM | 22978P106 | 646 | 26,371 | SH | SOLE | 26,371 | 0 | 0 | ||
| CYTOKINETICS INC | NOTE 4.000%11/1 | 23282WAA8 | 238,260 | 10,000,000 | PRN | SOLE | 10,000,000 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 21,467 | 2,577,043 | SH | SOLE | 2,577,043 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 32,125 | 7,317,809 | SH | SOLE | 7,317,809 | 0 | 0 | ||
| DENALI THERAPEUTICS INC | COM | 28423R105 | 20,553 | 850,000 | SH | SOLE | 850,000 | 0 | 0 | ||
| DERMTECH INC | COM | 24984K105 | 6,445 | 487,121 | SH | SOLE | 487,121 | 0 | 0 | ||
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 20,320 | 800,000 | SH | SOLE | 800,000 | 0 | 0 | ||
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 1,570 | 176,950 | SH | SOLE | 176,950 | 0 | 0 | ||
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 30,115 | 686,922 | SH | SOLE | 686,922 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,343 | 139,890 | SH | SOLE | 139,890 | 0 | 0 | ||
| ESTABLISHMENT LABS HOLDINGS INC | SHS | G31249108 | 13,750 | 736,121 | SH | SOLE | 736,121 | 0 | 0 | ||
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 58,113 | 1,250,000 | SH | SOLE | 1,250,000 | 0 | 0 | ||
| FERRARI N.V | SHS | N3167Y103 | 1,060 | 6,200 | SH | SOLE | 6,200 | 0 | 0 | ||
| FREQUENCY THERAPEUTICS INC | COM | 35803L108 | 70,547 | 3,034,296 | SH | SOLE | 3,034,296 | 0 | 0 | ||
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 15,768 | 894,118 | SH | SOLE | 894,118 | 0 | 0 | ||
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | 35,955 | 2,235,983 | SH | SOLE | 2,235,983 | 0 | 0 | ||
| GALERA THERAPEUTICS INC | COM | 36338D108 | 2,321 | 325,000 | SH | SOLE | 325,000 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 29,346 | 13,461,538 | SH | SOLE | 13,461,538 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 368,811 | 5,842,100 | SH | SOLE | 5,842,100 | 0 | 0 | ||
| HEALTH CATALYST INC | COM | 42225T107 | 9,795 | 335,782 | SH | SOLE | 335,782 | 0 | 0 | ||
| HOLOGIC INC | COM | 436440101 | 13,110 | 230,000 | SH | SOLE | 230,000 | 0 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 12,834 | 362,140 | SH | SOLE | 362,140 | 0 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 3,544 | 100,000 | SH | Put | SOLE | 100,000 | 0 | 0 | |
| IMMUNOVANT INC | COM | 45258J102 | 26,785 | 1,100,000 | SH | SOLE | 1,100,000 | 0 | 0 | ||
| INARI MED INC | COM | 45332Y109 | 33,714 | 696,000 | SH | SOLE | 696,000 | 0 | 0 | ||
| INSULET CORP | COM | 45784P101 | 10,244 | 52,733 | SH | SOLE | 52,733 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 324,170 | 11,809,494 | SH | SOLE | 11,809,494 | 0 | 0 | ||
| IVERIC BIO INC | COM | 46583P102 | 17,755 | 3,481,431 | SH | SOLE | 3,481,431 | 0 | 0 | ||
| KADMON HLDGS INC | COM | 48283N106 | 80,442 | 15,711,334 | SH | SOLE | 15,711,334 | 0 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 774 | 6,944 | SH | SOLE | 6,944 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 190,154 | 3,513,572 | SH | SOLE | 3,513,572 | 0 | 0 | ||
| LEAP THERAPEUTICS INC | COM | 52187K101 | 17,466 | 8,476,496 | SH | SOLE | 8,476,496 | 0 | 0 | ||
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 1,064 | 25,000 | SH | SOLE | 25,000 | 0 | 0 | ||
| LIFESCI ACQUISITION CORP | UNIT 03/31/2025 | 53228P208 | 3,300 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| LIVONGO HEALTH INC | COM | 539183103 | 1,024 | 13,620 | SH | SOLE | 13,620 | 0 | 0 | ||
| LONGVIEW ACQUISITION CORP | UNIT 99/99/9999 | 543195200 | 7,070 | 700,000 | SH | SOLE | 700,000 | 0 | 0 | ||
| LUMINEX CORP DEL | COM | 55027E102 | 616 | 18,926 | SH | SOLE | 18,926 | 0 | 0 | ||
| LYRA THERAPEUTICS INC | COM | 55234L105 | 36,543 | 3,222,561 | SH | SOLE | 3,222,561 | 0 | 0 | ||
| MACROGENICS INC | COM | 556099109 | 35,961 | 1,288,014 | SH | SOLE | 1,288,014 | 0 | 0 | ||
| MEDTRONIC PLC | SHS | G5960L103 | 1,834 | 20,000 | SH | SOLE | 20,000 | 0 | 0 | ||
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 80,544 | 6,433,277 | SH | SOLE | 6,433,277 | 0 | 0 | ||
| MENLO THERAPEUTICS INC | COM | 586858102 | 39,576 | 22,876,410 | SH | SOLE | 22,876,410 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 316,371 | 2,771,050 | SH | SOLE | 2,771,050 | 0 | 0 | ||
| MODERNA INC | COM | 60770K107 | 6,421 | 100,000 | SH | Put | SOLE | 100,000 | 0 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 34,118 | 2,474,133 | SH | SOLE | 2,474,133 | 0 | 0 | ||
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 1,019 | 30,637 | SH | SOLE | 30,637 | 0 | 0 | ||
| MORPHIC HLDG INC | COM | 61775R105 | 17,583 | 650,000 | SH | SOLE | 650,000 | 0 | 0 | ||
| MOTUS GI HLDGS INC | COM | 62014P108 | 5,557 | 4,210,542 | SH | SOLE | 4,210,542 | 0 | 0 | ||
| MYLAN N.V | SHS EURO | N59465109 | 16,151 | 1,004,419 | SH | SOLE | 1,004,419 | 0 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 134,787 | 1,395,017 | SH | SOLE | 1,395,017 | 0 | 0 | ||
| NEOLEUKIN THERAPEUTICS INC | COM | 64049K104 | 8,921 | 537,425 | SH | SOLE | 537,425 | 0 | 0 | ||
| NEPTUNE WELLNESS SOLUTIONS I | COM | 64079L105 | 51,623 | 18,436,906 | SH | SOLE | 18,436,906 | 0 | 0 | ||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 261,252 | 2,141,410 | SH | SOLE | 2,141,410 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 107,520 | 899,972 | SH | SOLE | 899,972 | 0 | 0 | ||
| NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | 121,500 | 9,000,000 | PRN | SOLE | 9,000,000 | 0 | 0 | ||
| NOVAVAX INC | COM NEW | 670002401 | 29,173 | 350,000 | SH | SOLE | 350,000 | 0 | 0 | ||
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 108 | 420,875 | SH | SOLE | 420,875 | 0 | 0 | ||
| PHREESIA INC | COM | 71944F106 | 1,979 | 70,000 | SH | SOLE | 70,000 | 0 | 0 | ||
| PROVENTION BIO INC | COM | 74374N102 | 63,858 | 4,525,711 | SH | SOLE | 4,525,711 | 0 | 0 | ||
| QUOTIENT LTD | COM | G73268107 | 98,338 | 13,289,054 | SH | SOLE | 13,289,054 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 9,354 | 15,000 | SH | SOLE | 15,000 | 0 | 0 | ||
| REPRO MED SYS INC | COM | 759910102 | 672 | 74,813 | SH | SOLE | 74,813 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 28,871 | 3,240,112 | SH | SOLE | 3,240,112 | 0 | 0 | ||
| RETROPHIN INC | NOTE 2.500% 9/1 | 761299AB2 | 349,979 | 45,000,000 | PRN | SOLE | 45,000,000 | 0 | 0 | ||
| REVANCE THERAPEUTICS INC | COM | 761330109 | 1,608 | 65,839 | SH | SOLE | 65,839 | 0 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 11,050 | 350,000 | SH | SOLE | 350,000 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 45,816 | 2,189,010 | SH | SOLE | 2,189,010 | 0 | 0 | ||
| SC HEALTH CORP | UNIT 99/99/9999 | G78516302 | 10,110 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 807 | 66,655 | SH | SOLE | 66,655 | 0 | 0 | ||
| SILK RD MED INC | COM | 82710M100 | 16,132 | 385,100 | SH | SOLE | 385,100 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 83422E105 | 19,777 | 6,749,803 | SH | SOLE | 6,749,803 | 0 | 0 | ||
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 147,603 | 3,514,358 | SH | SOLE | 3,514,358 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 16,013 | 671,978 | SH | SOLE | 671,978 | 0 | 0 | ||
| TG THERAPEUTICS INC | COM | 88322Q108 | 580 | 29,762 | SH | SOLE | 29,762 | 0 | 0 | ||
| TRANSLATE BIO INC | COM | 89374L104 | 5,649 | 315,237 | SH | SOLE | 315,237 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 928 | 114,674 | SH | SOLE | 114,674 | 0 | 0 | ||
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 21,308 | 329,890 | SH | SOLE | 329,890 | 0 | 0 | ||
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 12,356 | 272,756 | SH | SOLE | 272,756 | 0 | 0 | ||
| UROVANT SCIENCES LTD | COM | G9381B108 | 23,289 | 2,366,831 | SH | SOLE | 2,366,831 | 0 | 0 | ||
| VAPOTHERM INC | COM | 922107107 | 54,876 | 1,338,760 | SH | SOLE | 1,338,760 | 0 | 0 | ||
| VAXCYTE INC | COM | 92243G108 | 26,869 | 850,000 | SH | SOLE | 850,000 | 0 | 0 | ||
| VBI VACCINES INC | COM NEW | 91822J103 | 170,631 | 55,042,465 | SH | SOLE | 55,042,465 | 0 | 0 | ||
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 37,549 | 3,410,412 | SH | SOLE | 3,410,412 | 0 | 0 | ||
| VERU INC | COM | 92536C103 | 5,511 | 1,650,000 | SH | SOLE | 1,650,000 | 0 | 0 | ||
| VIEWRAY INC | COM | 92672L107 | 5,492 | 2,451,748 | SH | SOLE | 2,451,748 | 0 | 0 | ||
| VIR BIOTECHNOLOGY INC | COM | 92764N102 | 534 | 13,024 | SH | SOLE | 13,024 | 0 | 0 | ||
| VOCERA COMMUNICATIONS INC | COM | 92857F107 | 6,148 | 290,000 | SH | SOLE | 290,000 | 0 | 0 | ||
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 15,352 | 355,366 | SH | SOLE | 355,366 | 0 | 0 | ||
| ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 45,783 | 1,050,003 | SH | SOLE | 1,050,003 | 0 | 0 | ||
| ZOGENIX INC | COM NEW | 98978L204 | 132,542 | 4,907,139 | SH | SOLE | 4,907,139 | 0 | 0 | ||
| ZYMEWORKS INC | COM | 98985W102 | 129,166 | 3,580,999 | SH | SOLE | 3,580,999 | 0 | 0 | ||