The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 1LIFE HEALTHCARE INC | COM | 68269G107 | 7,936 | 279,844 | SH | SOLE | 279,844 | 0 | 0 | ||
| ACCOLADE INC | COM | 00437E102 | 11,394 | 293,138 | SH | SOLE | 293,138 | 0 | 0 | ||
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 3,192 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | 40,363 | 830,000 | SH | SOLE | 830,000 | 0 | 0 | ||
| ADMA BIOLOGICS INC | COM | 000899104 | 39,638 | 16,584,802 | SH | SOLE | 16,584,802 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 48,397 | 15,919,925 | SH | SOLE | 15,919,925 | 0 | 0 | ||
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 675 | 21,938 | SH | SOLE | 21,938 | 0 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 78,758 | 2,360,139 | SH | SOLE | 2,360,139 | 0 | 0 | ||
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 46,575 | 6,285,458 | SH | SOLE | 6,285,458 | 0 | 0 | ||
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | 43,132 | 1,143,790 | SH | SOLE | 1,143,790 | 0 | 0 | ||
| ALPHATEC HLDGS INC | COM NEW | 02081G201 | 3,729 | 561,574 | SH | SOLE | 561,574 | 0 | 0 | ||
| AMERICAN WELL CORP | CL A | 03044L105 | 13,486 | 455,000 | SH | SOLE | 455,000 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 354,723 | 25,122,048 | SH | SOLE | 25,122,048 | 0 | 0 | ||
| AMYRIS INC | COM NEW | 03236M200 | 8,568 | 3,333,332 | SH | SOLE | 3,333,332 | 0 | 0 | ||
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 | 8,496 | 1,750,000 | SH | SOLE | 1,750,000 | 0 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 46,753 | 625,129 | SH | SOLE | 625,129 | 0 | 0 | ||
| ATHENEX INC | COM | 04685N103 | 161,323 | 13,532,467 | SH | SOLE | 13,532,467 | 0 | 0 | ||
| ATHIRA PHARMA INC | COM | 04746L104 | 57,499 | 3,114,805 | SH | SOLE | 3,114,805 | 0 | 0 | ||
| ATRICURE INC | COM | 04963C209 | 8,636 | 216,449 | SH | SOLE | 216,449 | 0 | 0 | ||
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 34,788 | 1,235,818 | SH | SOLE | 1,235,818 | 0 | 0 | ||
| BCTG ACQUISITION CORP | COM | 05492W103 | 5,180 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| BIO RAD LABS INC | CL A | 090572207 | 252 | 489 | SH | SOLE | 489 | 0 | 0 | ||
| BIOGEN INC | COM | 09062X103 | 28,368 | 100,000 | SH | Call | SOLE | 100,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 61,606 | 664,574 | SH | SOLE | 664,574 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 251,619 | 6,706,268 | SH | SOLE | 6,706,268 | 0 | 0 | ||
| BURNING ROCK BIOTECH LTD | SPONSORED ADS | 12233L107 | 3,762 | 150,000 | SH | SOLE | 150,000 | 0 | 0 | ||
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 738 | 49,751 | SH | SOLE | 49,751 | 0 | 0 | ||
| COHERUS BIOSCIENCES INC | COM | 19249H103 | 66,693 | 3,636,485 | SH | SOLE | 3,636,485 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 42,849 | 2,058,068 | SH | SOLE | 2,058,068 | 0 | 0 | ||
| COLLEGIUM PHARMACEUTICAL INC | NOTE 2.625% 2/1 | 19459JAA2 | 163,765 | 17,500,000 | PRN | SOLE | 17,500,000 | 0 | 0 | ||
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 36,554 | 1,047,404 | SH | SOLE | 1,047,404 | 0 | 0 | ||
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 21,119 | 2,150,641 | SH | SOLE | 2,150,641 | 0 | 0 | ||
| COVETRUS INC | COM | 22304C100 | 636 | 26,075 | SH | SOLE | 26,075 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 57,342 | 3,659,381 | SH | SOLE | 3,659,381 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 112,187 | 1,341,308 | SH | SOLE | 1,341,308 | 0 | 0 | ||
| CYTOKINETICS INC | NOTE 4.000%11/1 | 23282WAA8 | 218,301 | 9,770,000 | PRN | SOLE | 9,770,000 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 17,137 | 2,577,043 | SH | SOLE | 2,577,043 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 11,776 | 6,806,975 | SH | SOLE | 6,806,975 | 0 | 0 | ||
| DEERFIELD HEALTHCARE TECH AC | UNIT 07/16/2025 | 244413209 | 3,189 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 14,392 | 800,000 | SH | SOLE | 800,000 | 0 | 0 | ||
| DYNE THERAPEUTICS INC | COM | 26818M108 | 8,076 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 34,710 | 686,922 | SH | SOLE | 686,922 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,138 | 139,890 | SH | SOLE | 139,890 | 0 | 0 | ||
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 | 12,575 | 678,633 | SH | SOLE | 678,633 | 0 | 0 | ||
| FERRARI N V | COM | N3167Y103 | 1,141 | 6,200 | SH | SOLE | 6,200 | 0 | 0 | ||
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 62,300 | 1,250,000 | SH | SOLE | 1,250,000 | 0 | 0 | ||
| FREQUENCY THERAPEUTICS INC | COM | 35803L108 | 62,558 | 3,256,518 | SH | SOLE | 3,256,518 | 0 | 0 | ||
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | 26,877 | 2,235,983 | SH | SOLE | 2,235,983 | 0 | 0 | ||
| GALERA THERAPEUTICS INC | COM | 36338D108 | 2,938 | 325,000 | SH | SOLE | 325,000 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 23,423 | 13,461,538 | SH | SOLE | 13,461,538 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 319,867 | 5,800,996 | SH | SOLE | 5,800,996 | 0 | 0 | ||
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 | 14,759 | 435,377 | SH | SOLE | 435,377 | 0 | 0 | ||
| HEALTH CATALYST INC | COM | 42225T107 | 10,654 | 291,084 | SH | SOLE | 291,084 | 0 | 0 | ||
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 | 4,950 | 450,000 | SH | SOLE | 450,000 | 0 | 0 | ||
| HOLOGIC INC | COM | 436440101 | 11,300 | 170,000 | SH | SOLE | 170,000 | 0 | 0 | ||
| IMMATICS N.V | SHS | N44445109 | 26,525 | 2,500,000 | SH | SOLE | 2,500,000 | 0 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 77,559 | 912,140 | SH | SOLE | 912,140 | 0 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | 49,266 | 1,400,000 | SH | SOLE | 1,400,000 | 0 | 0 | ||
| INARI MED INC | COM | 45332Y109 | 58,563 | 848,500 | SH | SOLE | 848,500 | 0 | 0 | ||
| INSULET CORP | COM | 45784P101 | 8,927 | 37,733 | SH | SOLE | 37,733 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 332,019 | 10,085,632 | SH | SOLE | 10,085,632 | 0 | 0 | ||
| IVERIC BIO INC | COM | 46583P102 | 19,635 | 3,481,431 | SH | SOLE | 3,481,431 | 0 | 0 | ||
| KADMON HLDGS INC | COM | 48283N106 | 61,588 | 15,711,334 | SH | SOLE | 15,711,334 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 61,757 | 1,043,021 | SH | SOLE | 1,043,021 | 0 | 0 | ||
| LEAP THERAPEUTICS INC | COM | 52187K101 | 16,783 | 8,476,496 | SH | SOLE | 8,476,496 | 0 | 0 | ||
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 772 | 25,000 | SH | SOLE | 25,000 | 0 | 0 | ||
| LIFESCI ACQUISITION CORP | UNIT 03/31/2025 | 53228P208 | 4,080 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| LIVONGO HEALTH INC | COM | 539183103 | 1,493 | 10,663 | SH | SOLE | 10,663 | 0 | 0 | ||
| LONGVIEW ACQUISITION CORP | UNIT 99/99/9999 | 543195200 | 7,105 | 700,000 | SH | SOLE | 700,000 | 0 | 0 | ||
| LYRA THERAPEUTICS INC | COM | 55234L105 | 36,028 | 3,222,561 | SH | SOLE | 3,222,561 | 0 | 0 | ||
| MACROGENICS INC | COM | 556099109 | 32,525 | 1,291,181 | SH | SOLE | 1,291,181 | 0 | 0 | ||
| MEIRAGTX HLDGS PLC | COM | G59665102 | 85,176 | 6,433,277 | SH | SOLE | 6,433,277 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 570,477 | 3,435,575 | SH | SOLE | 3,435,575 | 0 | 0 | ||
| MOLECULAR TEMPLATES INC | COM | 608550109 | 27,018 | 2,474,133 | SH | SOLE | 2,474,133 | 0 | 0 | ||
| MORPHIC HLDG INC | COM | 61775R105 | 13,314 | 487,000 | SH | SOLE | 487,000 | 0 | 0 | ||
| MOTUS GI HLDGS INC | COM | 62014P108 | 4,027 | 4,210,542 | SH | SOLE | 4,210,542 | 0 | 0 | ||
| MYLAN N.V | SHS EURO | N59465109 | 14,895 | 1,004,419 | SH | SOLE | 1,004,419 | 0 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 190,183 | 1,395,017 | SH | SOLE | 1,395,017 | 0 | 0 | ||
| NEPTUNE WELLNESS SOLUTIONS I | COM | 64079L105 | 41,012 | 19,436,906 | SH | SOLE | 19,436,906 | 0 | 0 | ||
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 148,924 | 1,548,715 | SH | SOLE | 1,548,715 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 115,085 | 826,164 | SH | SOLE | 826,164 | 0 | 0 | ||
| NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | 141,822 | 9,000,000 | PRN | SOLE | 9,000,000 | 0 | 0 | ||
| NOVAVAX INC | COM NEW | 670002401 | 76,681 | 707,715 | SH | SOLE | 707,715 | 0 | 0 | ||
| OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 54 | 420,875 | SH | SOLE | 420,875 | 0 | 0 | ||
| OUTSET MED INC | COM | 690145107 | 142,391 | 2,847,822 | SH | SOLE | 2,847,822 | 0 | 0 | ||
| PERSONALIS INC | COM | 71535D106 | 591 | 27,272 | SH | SOLE | 27,272 | 0 | 0 | ||
| PMV PHARMACEUTICALS INC | COM | 69353Y103 | 21,497 | 605,556 | SH | SOLE | 605,556 | 0 | 0 | ||
| POSEIDA THERAPEUTICS INC | COM | 73730P108 | 6,987 | 787,745 | SH | SOLE | 787,745 | 0 | 0 | ||
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 10,242 | 608,544 | SH | SOLE | 608,544 | 0 | 0 | ||
| PROVENTION BIO INC | COM | 74374N102 | 54,729 | 4,265,711 | SH | SOLE | 4,265,711 | 0 | 0 | ||
| QUOTIENT LTD | SHS | G73268107 | 83,272 | 16,200,818 | SH | SOLE | 16,200,818 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 2,799 | 5,000 | SH | SOLE | 5,000 | 0 | 0 | ||
| RELAY THERAPEUTICS INC | COM | 75943R102 | 99,209 | 2,329,407 | SH | SOLE | 2,329,407 | 0 | 0 | ||
| REPLIMUNE GROUP INC | COM | 76029N106 | 443 | 19,230 | SH | SOLE | 19,230 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 59,812 | 3,240,112 | SH | SOLE | 3,240,112 | 0 | 0 | ||
| RETROPHIN INC | NOTE 2.500% 9/1 | 761299AB2 | 390,119 | 45,000,000 | PRN | SOLE | 45,000,000 | 0 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 7,803 | 224,224 | SH | SOLE | 224,224 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 50,041 | 2,189,010 | SH | SOLE | 2,189,010 | 0 | 0 | ||
| SC HEALTH CORP | UNIT 99/99/9999 | G78516302 | 10,600 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 711 | 66,655 | SH | SOLE | 66,655 | 0 | 0 | ||
| SILK RD MED INC | COM | 82710M100 | 34,956 | 520,100 | SH | SOLE | 520,100 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 83422E105 | 13,702 | 6,749,803 | SH | SOLE | 6,749,803 | 0 | 0 | ||
| SPDR SER TR | S&P BIOTECH | 78464A870 | 22,286 | 200,000 | SH | Put | SOLE | 200,000 | 0 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 165,946 | 3,481,148 | SH | SOLE | 3,481,148 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 22,505 | 671,978 | SH | SOLE | 671,978 | 0 | 0 | ||
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 10,538 | 470,440 | SH | SOLE | 470,440 | 0 | 0 | ||
| TCR2 THERAPEUTICS INC | COM | 87808K106 | 8,128 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| TG THERAPEUTICS INC | COM | 88322Q108 | 907 | 33,893 | SH | SOLE | 33,893 | 0 | 0 | ||
| THERAPEUTICS ACQUISITION COR | COM CL A | 88339T103 | 21,570 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| TRANSLATE BIO INC | COM | 89374L104 | 4,290 | 315,237 | SH | SOLE | 315,237 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 1,630 | 114,674 | SH | SOLE | 114,674 | 0 | 0 | ||
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 28,819 | 329,890 | SH | SOLE | 329,890 | 0 | 0 | ||
| TWIST BIOSCIENCE CORP | COM | 90184D100 | 8,566 | 112,756 | SH | SOLE | 112,756 | 0 | 0 | ||
| UNUM THERAPEUTICS INC | COM | 903214104 | 18,615 | 7,955,000 | SH | SOLE | 7,955,000 | 0 | 0 | ||
| UROVANT SCIENCES LTD | SHS | G9381B108 | 22,106 | 2,366,831 | SH | SOLE | 2,366,831 | 0 | 0 | ||
| VANECK VECTORS ETF TR | PHARMACEUTICAL | 92189F692 | 12,434 | 200,000 | SH | Put | SOLE | 200,000 | 0 | 0 | |
| VAXCYTE INC | COM | 92243G108 | 41,973 | 850,000 | SH | SOLE | 850,000 | 0 | 0 | ||
| VBI VACCINES INC | COM NEW | 91822J103 | 157,421 | 55,042,465 | SH | SOLE | 55,042,465 | 0 | 0 | ||
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 18,027 | 2,888,889 | SH | SOLE | 2,888,889 | 0 | 0 | ||
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 26,397 | 3,410,412 | SH | SOLE | 3,410,412 | 0 | 0 | ||
| VERU INC | COM | 92536C103 | 4,323 | 1,650,000 | SH | SOLE | 1,650,000 | 0 | 0 | ||
| VIEWRAY INC | COM | 92672L107 | 8,581 | 2,451,748 | SH | SOLE | 2,451,748 | 0 | 0 | ||
| VYNE THERAPEUTICS INC | COM NEW | 92941V100 | 37,975 | 22,876,410 | SH | SOLE | 22,876,410 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 21,225 | 2,500,000 | SH | SOLE | 2,500,000 | 0 | 0 | ||
| ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 34,325 | 1,050,003 | SH | SOLE | 1,050,003 | 0 | 0 | ||
| ZYMEWORKS INC | COM | 98985W102 | 204,999 | 4,400,999 | SH | SOLE | 4,400,999 | 0 | 0 | ||