Perceptive Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABSCI CORPORATION	COM	00091E109	2,156,000	700,000	SH		SOLE		700,000	0	0
ACRIVON THERAPEUTICS INC	COMMON STOCK	004890109	31,092,976	5,360,858	SH		SOLE		5,360,858	0	0
ADMA BIOLOGICS INC	COM	000899104	30,979,780	2,771,000	SH		SOLE		2,771,000	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	35,187,584	1,499,897	SH		SOLE		1,499,897	0	0
ALDEYRA THERAPEUTICS INC	COM	01438T106	30,703,067	9,275,851	SH		SOLE		9,275,851	0	0
ALLOGENE THERAPEUTICS INC	COM	019770106	6,349,250	2,725,000	SH		SOLE		2,725,000	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	278,329,964	28,057,456	SH		SOLE		28,057,456	0	0
APOGEE THERAPEUTICS INC	COM	03770N101	82,856,776	2,105,636	SH		SOLE		2,105,636	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	37,383,350	8,005,000	SH		SOLE		8,005,000	0	0
ARCA BIOPHARMA INC	COM	00211Y506	59,394,720	15,507,760	SH		SOLE		15,507,760	0	0
ARCELLX INC	COMMON STOCK	03940C100	214,674,695	3,889,739	SH		SOLE		3,889,739	0	0
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	14,494,050	1,558,500	SH		SOLE		1,558,500	0	0
ARGENX SE	SPONSORED ADR	04016X101	6,708,624	15,600	SH		SOLE		15,600	0	0
ARRIVENT BIOPHARMA INC	COM	04272N102	7,698,250	415,000	SH		SOLE		415,000	0	0
ARS PHARMACEUTICALS INC	COM	82835W108	7,380,885	867,319	SH		SOLE		867,319	0	0
ARTIVION INC	COM	228903100	71,658,482	2,793,703	SH		SOLE		2,793,703	0	0
ARVINAS INC	COM	04335A105	27,358,678	1,027,749	SH		SOLE		1,027,749	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	59,017,322	6,485,420	SH		SOLE		6,485,420	0	0
ATHIRA PHARMA INC	COM	04746L104	14,317,855	5,402,964	SH		SOLE		5,402,964	0	0
AXOGEN INC	COM	05463X106	220,248	30,421	SH		SOLE		30,421	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	36,958,436	459,111	SH		SOLE		459,111	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	11,577,280	572,000	SH		SOLE		572,000	0	0
BIOHAVEN LTD	COM	G1110E107	51,552,403	1,485,232	SH		SOLE		1,485,232	0	0
BIODESIX INC	COM	09075X108	3,326,036	2,173,880	SH		SOLE		2,173,880	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	30,784,714	1,215,346	SH		SOLE		1,215,346	0	0
CABALETTA BIO INC	COM	12674W109	4,376,137	585,045	SH		SOLE		585,045	0	0
CAREMAX INC	CL A NEW	14171W202	342,174	122,643	SH		SOLE		122,643	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	846	60,000	SH		SOLE		60,000	0	0
CARGO THERAPEUTICS INC	COM	14179K101	60,474,925	3,683,004	SH		SOLE		3,683,004	0	0
CASSAVA SCIENCES INC	COM	14817C107	2,260,050	183,000	SH	Put	SOLE		183,000	0	0
CELCUITY INC	COM	15102K100	38,694,130	2,362,279	SH		SOLE		2,362,279	0	0
CENTESSA PHARMACEUTICALS PLC	SPONSORED ADS	152309100	35,517,762	3,933,307	SH		SOLE		3,933,307	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	441,402,480	10,794,876	SH		SOLE		10,794,876	0	0
CG ONCOLOGY INC	COM	156944100	23,162,751	733,695	SH		SOLE		733,695	0	0
CONTINEUM THERAPEUTICS INC	CL A	21217B100	15,849,000	900,000	SH		SOLE		900,000	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	66,119,132	1,476,203	SH		SOLE		1,476,203	0	0
CULLINAN THERAPEUTICS INC	COM	230031106	13,078,535	749,916	SH		SOLE		749,916	0	0
DISC MEDICINE INC	COM	254604101	24,943,406	553,437	SH		SOLE		553,437	0	0
EAGLE PHARMACEUTICALS INC	COM	269796108	970,844	173,365	SH		SOLE		173,365	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	33,434,070	1,856,417	SH		SOLE		1,856,417	0	0
ENGENE HOLDINGS INC	COM	29286M105	7,544,000	800,000	SH		SOLE		800,000	0	0
ENVVENO MEDICAL CORPORATION	COM	29415J106	3,272,404	623,315	SH		SOLE		623,315	0	0
EVOLUS INC	COM	30052C107	62,428,708	5,753,798	SH		SOLE		5,753,798	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	5,570,384	640,274	SH		SOLE		640,274	0	0
FATE THERAPEUTICS INC	COM	31189P102	1,133,486	345,575	SH		SOLE		345,575	0	0
FOGHORN THERAPEUTICS INC	COM	344174107	3,128,000	544,000	SH		SOLE		544,000	0	0
FORTE BIOSCIENCES INC	COM	34962G109	1,753,498	3,265,359	SH		SOLE		3,265,359	0	0
HELIX ACQUISITION CORP II	CL A ORD SHS	G4444H101	5,110,000	500,000	SH		SOLE		500,000	0	0
ICON PLC	SHS	G4705A100	9,795,938	31,250	SH		SOLE		31,250	0	0
IMMATICS N.V	SHS	N44445109	93,961,168	8,086,159	SH		SOLE		8,086,159	0	0
IMMUNOVANT INC	COM	45258J102	50,787,950	1,923,786	SH		SOLE		1,923,786	0	0
IMMUNOVANT INC	COM	45258J102	5,280,000	200,000	SH	Call	SOLE		200,000	0	0
INHIBRX BIOSCIENCES INC	COM	45720N103	15,077,248	1,064,026	SH		SOLE		1,064,026	0	0
INSMED INC	COM PAR $.01	457669307	12,060,000	180,000	SH		SOLE		180,000	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	117,556,715	1,716,407	SH		SOLE		1,716,407	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	27,491,730	61,800	SH		SOLE		61,800	0	0
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	207,983,798	25,933,142	SH		SOLE		25,933,142	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	3,789,466	35,205	SH		SOLE		35,205	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	5,890,000	500,000	SH		SOLE		500,000	0	0
KYVERNA THERAPEUTICS INC	COM	501976104	1,125,000	150,000	SH		SOLE		150,000	0	0
LIVANOVA PLC	SHS	G5509L101	24,340,080	444,000	SH		SOLE		444,000	0	0
LYRA THERAPEUTICS INC	COM	55234L105	3,533,844	12,757,562	SH		SOLE		12,757,562	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	74,130,336	264,600	SH		SOLE		264,600	0	0
MEDTRONIC PLC	SHS	G5960L103	38,620,242	490,665	SH		SOLE		490,665	0	0
MEIRAGTX HLDGS PLC	COM	G59665102	47,667,625	11,331,103	SH		SOLE		11,331,103	0	0
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	4,511,700	1,253,250	SH		SOLE		1,253,250	0	0
MERUS N V	COM	N5749R100	17,751,000	300,000	SH		SOLE		300,000	0	0
NANOBIOTIX	SPONSORED ADS	63009J107	2,775,330	555,066	SH		SOLE		555,066	0	0
NATERA INC	COM	632307104	57,393,700	530,000	SH		SOLE		530,000	0	0
NAUTILUS BIOTECHNOLOGY INC	COM	63909J108	29,470,453	12,594,211	SH		SOLE		12,594,211	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	89,472,972	649,909	SH		SOLE		649,909	0	0
NOVAVAX INC	COM NEW	670002401	1,266,000	100,000	SH	Put	SOLE		100,000	0	0
NUVALENT INC	COM	670703107	193,372,981	2,549,077	SH		SOLE		2,549,077	0	0
OCULAR THERAPEUTIX INC	COM	67576A100	22,739,361	3,324,468	SH		SOLE		3,324,468	0	0
ORCHESTRA BIOMED HLDGS INC	COM	68572M106	20,748,930	2,545,881	SH		SOLE		2,545,881	0	0
PEPGEN INC	COM	713317105	22,510,590	1,410,438	SH		SOLE		1,410,438	0	0
PRAXIS PRECISION MEDICINES I	COM NEW	74006W207	31,029,513	750,230	SH		SOLE		750,230	0	0
PRECISION BIOSCIENCES INC	COM NEW	74019P207	4,147,831	426,293	SH		SOLE		426,293	0	0
PROCEPT BIOROBOTICS CORP	COM	74276L105	12,869,158	210,659	SH		SOLE		210,659	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	43,961,668	1,268,735	SH		SOLE		1,268,735	0	0
RAPPORT THERAPEUTICS INC	COM	75383L102	17,402,737	748,183	SH		SOLE		748,183	0	0
RECURSION PHARMACEUTICALS IN	CL A	75629V104	5,769,225	769,230	SH		SOLE		769,230	0	0
REVANCE THERAPEUTICS INC	COM	761330109	1,542,000	600,000	SH		SOLE		600,000	0	0
REVOLUTION MEDICINES INC	*W EXP 12/17/202	76155X118	25,525	250,000	SH		SOLE		250,000	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	141,516,534	3,446,579	SH		SOLE		3,446,579	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	26,839,233	1,246,597	SH		SOLE		1,246,597	0	0
SINGULAR GENOMICS SYSTEMS IN	COM NEW	82933R308	599,071	70,896	SH		SOLE		70,896	0	0
SKYE BIOSCIENCE INC	COM NEW	83086J200	4,005,000	500,000	SH		SOLE		500,000	0	0
SOLENO THERAPEUTICS INC	COM	834203309	130,763,021	3,204,976	SH		SOLE		3,204,976	0	0
SOLID BIOSCIENCES INC	COM NEW	83422E204	39,160,682	6,906,646	SH		SOLE		6,906,646	0	0
SPDR SER TR	S&P BIOTECH	78464A870	2,101,272	22,665	SH		SOLE		22,665	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	62,267,079	1,652,962	SH		SOLE		1,652,962	0	0
SPYRE THERAPEUTICS INC	COM NEW	00773J202	71,259,233	3,031,018	SH		SOLE		3,031,018	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	1,368,638	34,852	SH		SOLE		34,852	0	0
SURROZEN INC	*W EXP 08/01/203	86889P117	2,767	166,666	SH		SOLE		166,666	0	0
SYROS PHARMACEUTICALS INC	COM NEW	87184Q206	602,451	116,754	SH		SOLE		116,754	0	0
TACTILE SYS TECHNOLOGY INC	COM	87357P100	747,910	62,639	SH		SOLE		62,639	0	0
TARSUS PHARMACEUTICALS INC	COM	87650L103	35,236,587	1,296,416	SH		SOLE		1,296,416	0	0
TEMPUS AI INC	CL A	88023B103	9,625,000	275,000	SH		SOLE		275,000	0	0
TRINITY BIOTECH PLC	SPONS ARD NEW	896438504	3,834,000	1,800,000	SH		SOLE		1,800,000	0	0
TYRA BIOSCIENCES INC	COM	90240B106	16,107,798	1,007,367	SH		SOLE		1,007,367	0	0
VAXCYTE INC	COM	92243G108	140,645,530	1,862,608	SH		SOLE		1,862,608	0	0
VBI VACCINES INC CDA	COM NEW	91822J202	832,728	1,261,710	SH		SOLE		1,261,710	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	35,191,664	2,433,725	SH		SOLE		2,433,725	0	0
VERRICA PHARMACEUTICALS INC	COM	92511W108	51,753,037	7,099,182	SH		SOLE		7,099,182	0	0
VERU INC	COM	92536C103	5,942,335	7,063,277	SH		SOLE		7,063,277	0	0
VIKING THERAPEUTICS INC	COM	92686J106	38,240,195	721,377	SH		SOLE		721,377	0	0
VIRIDIAN THERAPEUTICS INC	COM	92790C104	21,230,082	1,631,828	SH		SOLE		1,631,828	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	2,056,363	3,545,454	SH		SOLE		3,545,454	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	22,741,151	583,256	SH		SOLE		583,256	0	0
ZYMEWORKS INC	COM	98985Y108	14,192,221	1,667,711	SH		SOLE		1,667,711	0	0