Document and Entity Information
Document and Entity Information - USD ($) | 12 Months Ended | ||
Dec. 31, 2021 | Mar. 23, 2022 | Jun. 30, 2021 | |
Cover [Abstract] | |||
Document Type | 10-K | ||
Amendment Flag | false | ||
Document Annual Report | true | ||
Document Period End Date | Dec. 31, 2021 | ||
Current Fiscal Year End Date | --12-31 | ||
Document Fiscal Year Focus | 2021 | ||
Document Fiscal Period Focus | FY | ||
Document Transition Report | false | ||
Entity File Number | 001-34079 | ||
Entity Registrant Name | Ocuphire Pharma, Inc. | ||
Entity Central Index Key | 0001228627 | ||
Entity Incorporation, State or Country Code | DE | ||
Entity Tax Identification Number | 11-3516358 | ||
Entity Address, Address Line One | 37000 Grand River Avenue, Suite 120 | ||
Entity Address, City or Town | Farmington Hills | ||
Entity Address, State or Province | MI | ||
Entity Address, Postal Zip Code | 48335 | ||
City Area Code | 248 | ||
Local Phone Number | 681-9815 | ||
Title of 12(b) Security | Common Stock, $0.0001 par value per share | ||
Trading Symbol | OCUP | ||
Security Exchange Name | NASDAQ | ||
Entity Well-known Seasoned Issuer | No | ||
Entity Voluntary Filers | No | ||
Entity Current Reporting Status | Yes | ||
Entity Interactive Data Current | Yes | ||
Entity Filer Category | Non-accelerated Filer | ||
Entity Small Business | true | ||
Entity Emerging Growth Company | false | ||
ICFR Auditor Attestation Flag | false | ||
Entity Shell Company | false | ||
Entity Public Float | $ 83,840,460 | ||
Entity Common Stock, Shares Outstanding | 18,989,817 | ||
Auditor Name | Ernst & Young LLP | ||
Auditor Location | Detroit, Michigan | ||
Auditor Firm ID | 42 |
Consolidated Balance Sheets
Consolidated Balance Sheets - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Current assets: | ||
Cash and cash equivalents | $ 24,534 | $ 16,399 |
Prepaids and other current assets | 1,314 | 1,269 |
Short-term investments | 219 | 0 |
Total current assets | 26,067 | 17,668 |
Property and equipment, net | 10 | 14 |
Total assets | 26,077 | 17,682 |
Current liabilities: | ||
Accounts payable | 1,584 | 1,214 |
Accrued expenses | 1,733 | 1,971 |
Short-term loan | 538 | 0 |
Total current liabilities | 3,855 | 3,185 |
Warrant liabilities | 0 | 27,964 |
Total liabilities | 3,855 | 31,149 |
Commitments and contingencies (Note 3 and Note 9) | ||
Stockholders' equity (deficit) | ||
Preferred stock, par value $0.0001; 10,000,000 shares authorized as of December 31, 2021 and 2020; no shares issued and outstanding at December 31, 2021 and 2020. | 0 | 0 |
Common stock, par value $0.0001; 75,000,000 shares authorized as of December 31, 2021 and 2020; 18,845,828 and 10,882,495 shares issued and outstanding at December 31, 2021 and 2020, respectively. | 2 | 1 |
Additional paid-in-capital | 111,588 | 19,207 |
Accumulated deficit | (89,368) | (32,675) |
Total stockholders' equity (deficit) | 22,222 | (13,467) |
Total liabilities and stockholders' equity (deficit) | $ 26,077 | $ 17,682 |
Consolidated Balance Sheets (Pa
Consolidated Balance Sheets (Parenthetical) - $ / shares | Dec. 31, 2021 | Dec. 31, 2020 |
Stockholders' equity (deficit) | ||
Preferred stock, par value (in dollars per share) | $ 0.0001 | $ 0.0001 |
Preferred stock, shares authorized (in shares) | 10,000,000 | 10,000,000 |
Preferred stock, shares issued (in shares) | 0 | 0 |
Preferred stock, shares, outstanding (in shares) | 0 | 0 |
Common stock, par value (in dollars per share) | $ 0.0001 | $ 0.0001 |
Common stock, shares authorized (in shares) | 75,000,000 | 75,000,000 |
Common stock, shares issued (in shares) | 18,845,828 | 10,882,495 |
Common stock, shares, outstanding (in shares) | 18,845,828 | 10,882,495 |
Consolidated Statements of Comp
Consolidated Statements of Comprehensive Loss - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Consolidated Statements of Comprehensive Loss [Abstract] | ||
Collaborations revenue | $ 589,000 | $ 0 |
Operating expenses: | ||
General and administrative | 8,121,000 | 2,818,000 |
Research and development | 15,173,000 | 6,648,000 |
Acquired in-process research and development | 0 | 10,502,000 |
Total operating expenses | 23,294,000 | 19,968,000 |
Loss from operations | (22,705,000) | (19,968,000) |
Interest expense | (2,000) | (6,847,000) |
Fair value change of warrant liability and premium conversion derivatives | (33,829,000) | (1,486,000) |
Gain on note extinguishment | 0 | 3,672,000 |
Other (expense) income, net | (157,000) | 9,000 |
Loss before income taxes | (56,693,000) | (24,620,000) |
Benefit (provision) for income taxes | 0 | 0 |
Net loss | (56,693,000) | (24,620,000) |
Other comprehensive loss, net of tax | 0 | 0 |
Comprehensive loss | $ (56,693,000) | $ (24,620,000) |
Net loss per share: | ||
Basic (Note 11) (in dollars per share) | $ (3.82) | $ (5.28) |
Diluted (Note 11) (in dollars per share) | $ (3.82) | $ (5.28) |
Number of shares used in per share calculations: | ||
Basic (in shares) | 14,852,745 | 4,661,110 |
Diluted (in shares) | 14,852,745 | 4,661,110 |
Consolidated Statements of Chan
Consolidated Statements of Changes in Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Total |
Balance at Dec. 31, 2019 | $ 0 | $ 495 | $ (8,055) | $ (7,560) |
Balance (in shares) at Dec. 31, 2019 | 2,852,485 | |||
Increase (Decrease) in Stockholders' Equity [Roll Forward] | ||||
Issuance of common stock in exchange for in-process research and development | $ 0 | 2,126 | 0 | 2,126 |
Issuance of common stock in exchange for in-process research and development (in shares) | 891,422 | |||
Gain on note extinguishment | $ 0 | 971 | 0 | 971 |
Conversion of convertible notes into common stock upon close of the merger | $ 0 | 6,953 | 0 | 6,953 |
Conversion of convertible notes into common stock upon close of the merger (in shares) | 977,128 | |||
Issuance of common stock and warrants in connection with pre-merger financing | $ 1 | (1) | 0 | 0 |
Issuance of common stock and warrants in connection with pre-merger financing (in shares) | 4,999,988 | |||
Issuance costs attributed to pre-merger financing | $ 0 | (1,080) | 0 | (1,080) |
Issuance of common stock, warrants and options to former Rexahn stockholders and effect of asset acquisition | $ 0 | 8,115 | 0 | 8,115 |
Issuance of common stock, warrants and options to former Rexahn stockholders and effect of asset acquisition (in shares) | 1,120,800 | |||
Share-based compensation | $ 0 | 1,506 | 0 | 1,506 |
Reclassification of warrants from liability to equity | 0 | 64 | 0 | 64 |
Exercise of stock options | $ 0 | 58 | 0 | 58 |
Exercise of stock options (in shares) | 40,672 | |||
Net and comprehensive loss | $ 0 | 0 | (24,620) | (24,620) |
Balance at Dec. 31, 2020 | $ 1 | 19,207 | (32,675) | (13,467) |
Balance (in shares) at Dec. 31, 2020 | 10,882,495 | |||
Increase (Decrease) in Stockholders' Equity [Roll Forward] | ||||
Reclassification of Series A warrant liability to equity | $ 0 | 61,793 | 0 | 61,793 |
Issuance of common stock and warrants in connection with registered direct offering | $ 1 | 14,999 | 0 | 15,000 |
Issuance of common stock and warrants in connection with registered direct offering (in shares) | 3,076,923 | |||
Issuance of common stock in connection with the at-the-market program | $ 0 | 13,491 | 0 | 13,491 |
Issuance of common stock in connection with the at-the-market program (in shares) | 2,778,890 | |||
Issuance of common stock in connection with settlement with investors | $ 0 | 1,614 | 0 | 1,614 |
Issuance of common stock in connection with settlement with investors (in shares) | 350,000 | |||
Issuance costs | $ 0 | (1,517) | 0 | (1,517) |
Exercise of Series B warrants | $ 0 | 0 | 0 | 0 |
Exercise of Series B warrants (in shares) | 1,629,634 | |||
Share-based compensation | $ 0 | 1,914 | 0 | 1,914 |
Share-based compensation (in shares) | 54,444 | |||
Exercise of stock options | $ 0 | 87 | 0 | 87 |
Exercise of stock options (in shares) | 73,442 | |||
Net and comprehensive loss | $ 0 | 0 | (56,693) | (56,693) |
Balance at Dec. 31, 2021 | $ 2 | $ 111,588 | $ (89,368) | $ 22,222 |
Balance (in shares) at Dec. 31, 2021 | 18,845,828 |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Operating activities | ||
Net loss | $ (56,693,000) | $ (24,620,000) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Share-based compensation | 1,914,000 | 1,506,000 |
Depreciation | 4,000 | 8,000 |
Non-cash acquired in-process research and development | 0 | 10,502,000 |
Gain on note extinguishment | 0 | (3,672,000) |
Non-cash interest on convertible notes | 0 | 492,000 |
Non-cash interest on convertible notes - related party | 0 | 51,000 |
Non-cash discount amortization on convertible notes | 0 | 873,000 |
Non-cash discount amortization on convertible notes - related party | 0 | 71,000 |
Fair value change in warrant liabilities and premium conversion derivatives | 33,829,000 | 1,486,000 |
Non-cash interest attributed to Series A warrant issuance | 0 | 4,671,000 |
Issuance costs attributed to Series A warrants | 0 | 689,000 |
Non-cash share settlement with investors | 1,614,000 | 0 |
Receipt of investments related to license agreement | (289,000) | 0 |
Unrealized loss from short-term investments | 70,000 | 0 |
Change in assets and liabilities: | ||
Prepaid expenses and other assets | (45,000) | (906,000) |
Accounts payable | 381,000 | 792,000 |
Accrued expenses | (155,000) | 1,260,000 |
Net cash used in operating activities | (19,370,000) | (6,797,000) |
Investing activities | ||
Cash acquired in connection with asset acquisition | 0 | 2,014,000 |
Transaction costs in connection with asset acquisition | (100,000) | (1,475,000) |
Net cash (used in) provided by investing activities | (100,000) | 539,000 |
Financing activities | ||
Proceeds from pre-merger financing | 0 | 21,150,000 |
Proceeds from issuance of common stock | 28,491,000 | 0 |
Proceeds from issuance of convertible notes | 0 | 2,197,000 |
Issuance costs attributed to pre-merger financing | 0 | (1,769,000) |
Issuance costs attributed to common stock and convertible notes | (1,511,000) | (10,000) |
Proceeds from short-term loan | 646,000 | 0 |
Payment made on short-term loan principal | (108,000) | 0 |
Settlement of Rexahn warrants | 0 | (506,000) |
Exercise of stock options | 87,000 | 58,000 |
Net cash provided by financing activities | 27,605,000 | 21,120,000 |
Net increase in cash and cash equivalents | 8,135,000 | 14,862,000 |
Cash and cash equivalents at beginning of period | 16,399,000 | 1,537,000 |
Cash and cash equivalents at end of period | 24,534,000 | 16,399,000 |
Supplemental disclosure of cash flow information: | ||
Cash paid for income taxes | 0 | 0 |
Cash paid for interest | 2,000 | 0 |
Supplemental non-cash financing transactions: | ||
Non-cash reclassification of series A warrant liability to equity | 61,793,000 | 0 |
Non-cash conversion of convertible notes to common stock | 0 | 9,365,000 |
Common stock and warrants issued in connection with the asset acquisition | 0 | 8,883,000 |
Unpaid transaction costs in connection with asset acquisition | 0 | 100,000 |
Net assets assumed in connection with asset acquisition | 0 | 68,000 |
Bifurcation of premium conversion derivative related to convertible notes | 0 | 831,000 |
Unpaid issuance costs | $ 6,000 | $ 0 |
Company Description and Summary
Company Description and Summary of Significant Accounting Policies | 12 Months Ended |
Dec. 31, 2021 | |
Company Description and Summary of Significant Accounting Policies [Abstract] | |
Company Description and Summary of Significant Accounting Policies | 1. Company Description and Summary of Significant Accounting Policies Nature of Business Ocuphire is a clinical-stage ophthalmic biopharmaceutical company focused on developing and commercializing therapies for the treatment of refractive and retinal Ocuphire . The Company has also in-licensed second-generation product candidates and analogs of APX3330. The Company has sustained operating losses since inception and expects such losses to continue indefinitely until a sustained revenue source is realized. Management plans to continue financing the Company’s operations primarily through additional issuances of the Company’s equity and debt securities. If adequate funds are not available, the Company may be required to delay, reduce the scope of, or eliminate part or all of its research and development programs. Reverse Merger with Rexahn On June 17, 2020, Ocuphire, Rexahn Pharmaceuticals, Inc. (“Rexahn”), Razor Merger Sub, Inc., a Delaware corporation and wholly-owned subsidiary of Rexahn (“Merger Sub”), entered into an Agreement and Plan of Merger and Reorganization, as amended on June 29, 2020 (as amended, the “Merger Agreement”), pursuant to which, among other things, and subject to the satisfaction or waiver of certain conditions set forth in the Merger Agreement, Merger Sub would merge with and into Ocuphire, with Ocuphire continuing as a wholly-owned subsidiary of Rexahn and the surviving corporation of the merger (the “Merger”). The Merger closed on November 5, 2020. Upon completion of the Merger, Rexahn changed its name to Ocuphire Pharma, Inc. and changed its ticker symbol on the Nasdaq Capital Market to “OCUP”. The Company’s headquarters is located in Farmington Hills, Michigan. COVID-19 As a result of the COVID-19 pandemic, the Company has experienced, and will likely continue to experience, delays and disruptions in our clinical trials, as well as interruptions in our manufacturing, supply chain, shipping and research and development operations. The Company’s plans for further testing or clinical trials may be further impacted by the continuing effects of COVID-19. The global outbreak of COVID-19 continues to evolve. The extent to which the COVID-19 pandemic may further impact our business and clinical trials will depend on future developments, which are highly uncertain and cannot be predicted with confidence, such as the effect of the pandemic on our suppliers and distributors and the global supply chain, the ultimate geographic spread of the disease, the duration of the outbreak, travel restrictions and social distancing in the U.S. and other countries, business closures or business disruptions and the effectiveness of actions taken in the U.S. and other countries to contain and treat the disease. The COVID-19 pandemic may also continue to impact our business as a result of employee illness, school closures, and other community response measures. The COVID-19 pandemic may also impact the Company’s ability to secure additional financing. Although the Company cannot estimate the length or gravity of the impact of the COVID-19 outbreak at this time, if the pandemic continues, it may have a material adverse effect on the Company’s results of future operations, financial position, and liquidity in for fiscal year 2022 and beyond. Basis of Presentation The accompanying financial statements have been prepared in accordance with accounting standards generally accepted in the United States of America (“GAAP”). All of the share and per share amounts presented were adjusted, on a retroactive basis, to reflect the exchange of the shares of Ocuphire pre-Merger (“Private Ocuphire”) into 1.0565 shares of the Company (the “Exchange Ratio”), except for par value and share authorizations of Private Ocuphire for periods presented prior to the Merger. On December 31, 2021, the Company merged its wholly owned subsidiary, OcuSub Inc, with and into the Company, with the Company remaining as the surviving entity. The merger of the Company’s wholly owned subsidiary did not have a financial impact to the periods presented. Upon close of this merger, the Company did not have any remaining entities that required consolidation for financial statement reporting purposes. Going Concern The Company’s ability to continue operating as a going concern is contingent upon, among other things, its ability to secure additional financing and to achieve and maintain profitable operations. The Company plans to issue additional equity instruments and possibly debt to finance operating and working capital requirements. While the Company expects to obtain the additional financing that is needed, there is no assurance that the Company will be successful in obtaining the necessary funding for future operations. These factors raise substantial doubt as to the Company’s ability to continue as a going concern. The consolidated financial statements do not include any adjustments that might result from the outcome of these uncertainties. Common Stock Valuation Prior to the close of the Merger, due to the absence of an active market for the Private Ocuphire’s common stock, the Company utilized methodologies in accordance with the framework of the American Institute of Certified Public Accountants’ Technical Practice Aid, Valuation of Privately-Held Company Equity Securities Issued as Compensation For the valuation of equity awards granted in October 2020 and September 2020, the Company used a contemporaneous third-party valuation of $8.76 and $7.89 per share, respectively. For the valuation of equity awards granted in April 2020 and June 2020, the Company applied a straight-line calculation using the contemporaneous third-party valuations of $1.74 per share as of March 31, 2020 and $9.54 per share as of June 18, 2020 to determine the fair value of Private Ocuphire common stock. Using the benefit of hindsight, the Company determined that the straight-line calculation would provide the most reasonable conclusion for the valuation of the Company’s common stock on these interim dates between valuations because the Company did not identify any single event or series of events that occurred during this interim period that would have caused a material change in fair value. Based on this calculation, the Company assessed the fair value of its common stock for awards granted in April 2020 and June 2020 at $2.33 and $8.65 per share, respectively. Use of Estimates The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates. Segment Information Operating segments are components of an enterprise for which separate financial information is available and is evaluated regularly by the Company’s chief operating decision maker in deciding how to allocate resources and assessing performance. The Company’s chief operating decision maker is its Chief Executive Officer. The Company’s Chief Executive Officer views the Company’s operations and manages its business in one operating segment, which is the business of development and commercialization of products related to vision performance and health. Accordingly, the Company has a single reporting segment. Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of 90 days or less at the time of deposit to be cash equivalents. Concentration of Credit Risk Financial instruments that potentially subject the Company to a concentration of credit risk consist of cash and cash equivalents. The Company’s cash is held by two long-standing financial institutions in the United States. Amounts on deposit may at times exceed federally insured limits. Management believes that the financial institutions are financially sound, and accordingly, minimal credit risk exists with respect to the financial institutions. As of December 31, 2021, the Company had deposits that exceeded federally insured amounts by approximately $24.0 million. Short-term Investments The Company determines the appropriate classification of its investments in debt and equity securities at the time of purchase and are recorded on a settlement date basis. The Company’s investments are comprised of equity securities, which in accordance with the fair value hierarchy described below are recorded at fair value using Level l inputs on the consolidated balance sheets. Subsequent changes in fair values are recorded in other (expense) income, net on the consolidated statements of comprehensive loss. The Company classifies investments available to fund current operations as current assets on its consolidated balance sheets. The Company did not recognize any impairments on its investments to date through December 31, 2021. Revenue Recognition The Company follows the provisions of Accounting Standards Codification (“ASC”) 606, Revenue from Contracts with Customers . The guidance provides a five-step model to determine how revenue is recognized. The Company has entered into license agreements which have revenue recognition implications. (See Note 10 – Collaboration License Agreements.) In determining the appropriate amount of revenue to be recognized, the Company performs the following steps: (i) identification of the contracts with a customer; (ii) determination of the performance obligations in the contract; (iii) measurement of the transaction price, including potential constraints on variable consideration; (iv) allocation of the transaction price to the performance obligations based on estimated stand-alone selling prices; and (v) recognition of revenue when (or as) the Company satisfies a performance obligation. A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account in ASC 606. Performance obligations may include license rights, development services, and services associated with regulatory submission and approval processes. Significant management judgment is required to determine the level of effort required under an arrangement and the period over which the Company expects to complete its performance obligations under the arrangement. If the Company cannot reasonably estimate when its performance obligations are either completed or become inconsequential, then revenue recognition is deferred until the Company can reasonably make such estimates. Revenue is then recognized over the remaining estimated period of performance using the cumulative catch-up method. As part of the accounting for these arrangements, the Company must develop assumptions that require judgment to determine the stand-alone selling price of each performance obligation identified in the contract. The Company uses key assumptions to determine the stand-alone selling price, which may include forecasted revenues, development timelines, reimbursement rates for personnel costs, discount rates and probabilities of technical and regulatory success. The Company allocates the total transaction price to each performance obligation based on the estimated relative standalone selling prices of the promised goods or service underlying each performance obligation. Licenses of intellectual property: If the license to the Company’s intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, the Company recognizes revenues from non-refundable, up-front fees allocated to the license when the license is transferred to the customer, and the customer can use and benefit from the license. For licenses that are bundled with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. Milestone payments: At the inception of each arrangement that includes milestone payments, the Company evaluates whether the milestones are considered probable of being achieved and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the value of the associated milestone (such as a regulatory submission) is included in the transaction price. Milestone payments that are not within the control of the Company, such as approvals from regulators, are not considered probable of being achieved until such contingency occurs (such as receipt of those approvals). When the Company’s assessment of probability of achievement changes and variable consideration becomes probable, any additional estimated consideration is allocated to each performance obligation based on the estimated relative standalone selling prices of the promised goods or service underlying each performance obligation and recorded in collaborations revenue based upon when the customer obtains control of each element. Royalties: For arrangements that include sales-based royalties, including milestone payments based on the level of sales, and the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (a) when the related sales occur, or (b) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). General and Administrative Expenses General and administrative expenses (“G&A”) consist primarily of personnel-related costs, including salaries and stock-based compensation costs, for personnel in functions not directly associated with research and development activities. Other significant costs include legal fees relating to intellectual property and corporate matters, professional fees for accounting and tax services, settlement costs with third parties and other services provided by business consultants. Research and Development Research and development expenses (“R&D”) consist of costs incurred in performing research and development activities, including compensation for research and development employees and consultants, costs associated with preclinical studies and clinical trials, regulatory activities, manufacturing activities to support clinical activities, license fees, fees paid to external service providers that conduct certain research and development, and an allocation of R&D related overhead expenses. Acquired In‑Process Research and Development Expenses The Company includes costs to acquire or in‑license product candidates as acquired in‑process research and development expenses (“IPR&D”). These costs are immediately expensed provided that the payments do not also represent processes or activities that would constitute a “business” as defined under GAAP or provided that the product candidate has not achieved regulatory approval for marketing, and absent obtaining such approval, has no alternative future use. Royalties owed on future sales of any licensed product will be expensed in the period the related revenues are recognized. See Note 8 – Apexian Sublicense Agreement. Other (Expense) Income, net Other (expense) income, net reflected in this line item includes payments made by the Company in connection with the Contingent Value Rights Agreement discussed further below with former Rexahn shareholders. In addition, Other (expense) income, net includes interest earned from cash and cash equivalent investments, realized and unrealized gains (losses) from equity investments and reimbursements in connection with grants and other sources. Share‑Based Compensation The Company accounts for share‑based compensation in accordance with the provisions of the Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC 718”), Compensation — Stock Compensation Warrant Liabilities The Company issued Series A Warrants in connection with the Pre-Merger Financing (see Note 9 – Pre-Merger Financing) and assumed Rexahn warrants issued prior to the Merger. The Company accounts for these warrants as a liability while outstanding at fair value during periods when certain provisions preclude equity accounting treatment for these instruments. Additionally, issuance costs associated with the warrants classified as liabilities are expensed as incurred and reflected as interest expense in the accompanying consolidated statements of comprehensive loss. The change in fair value of the warrant liabilities while outstanding were recognized as a component of the fair value change in derivative and warrant liabilities line item in the consolidated statements of comprehensive loss. Premium Conversion Derivatives The Company evaluates all conversion and redemption features contained in a debt instrument to determine if there are any embedded derivatives that require separation from the host debt instrument. An embedded derivative that requires separation is bifurcated from its host debt instrument and a corresponding discount to the host debt instrument is recorded. The discount is amortized and recorded to interest expense over the term of the host debt instrument using the straight-line method which approximates the effective interest method. The embedded derivative is accounted for separately on a fair market value basis while outstanding. The Company records the fair value changes of a separated embedded derivative at each reporting period in the fair value change in derivative and warrant liabilities line item in the accompanying consolidated statements of comprehensive loss. The Company determined that the redemption features under the convertible notes, while they were outstanding, qualified as embedded derivatives and were separated from their debt hosts. Fair Value Measurements The Company follows accounting guidance that emphasizes that fair value is a market-based measurement, not an entity-specific measurement. Fair value is defined as “the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date.” Fair value measurements are defined on a three-level hierarchy: • Level 1 inputs: Unadjusted quoted prices for identical assets or liabilities in active markets; • Level 2 inputs: Quoted prices for similar assets and liabilities in active markets, quoted prices in markets that are not active, or inputs which are observable, whether directly or indirectly, for substantially the full term of the asset or liability; and • Level 3 inputs: Unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability in which there is little, if any, market activity for the asset or liability at the measurement date. As of December 31, 2021 and 2020, the fair values of cash and cash equivalents, prepaid and other assets, accounts payable, accrued expenses and short-term loan approximated their carrying values because of the short-term nature of these assets or liabilities. The estimated fair value of the Company’s convertible notes while outstanding were based on amortized cost which was deemed to approximate fair value. The fair value of the investments, while outstanding, were based on observable Level 1 inputs in the form of quoted market prices from a major stock exchange. The fair value of the warrant liabilities and premium conversion derivatives, while outstanding, were based on cash flow models discounted at current implied market rates evidenced in recent arms-length transactions representing expected returns by market participants for similar instruments and were based on Level 3 inputs. The fair value of financial instruments measured on a recurring basis is as follows (in thousands): As of December 31, 2021 Description Total Level 1 Level 2 Level 3 Assets: Short-term investments $ 219 $ 219 $ — $ — Total assets at fair value $ 219 $ 219 $ — $ — As of December 31, 2020 Description Total Level 1 Level 2 Level 3 Liabilities: Warrant liabilities $ 27,964 $ — $ — $ 27,964 Total liabilities at fair value $ 27,964 $ — $ — $ 27,964 The following table provides a roll-forward of investments measured at fair value on a recurring basis using observable level 1 inputs for the year ended December 31, 2021 and 2020 (in thousands): 2021 2020 Short-term investments Balance as of beginning of period $ — $ — Receipt of investments related to license agreement 289 — Unrealized loss (70 ) — Balance as of end of period $ 219 $ — The following table provides a roll-forward of the warrant liabilities and premium conversion derivatives measured at fair value on a recurring basis using unobservable level 3 inputs for the years ended December 31, 2021 and 2020 (in thousands): 2021 2020 Warrant liabilities Balance as of beginning of period $ 27,964 $ — Value assigned to warrants upon in connection with pre-merger financing — 25,821 Issuance of warrants to former Rexahn stockholders classified as a liability — 768 Cash settlement of warrant liabilities — (506 ) Change in fair value of warrant liabilities 33,829 1,945 Reclassification of warrants from liability to equity (61,793 ) (64 ) Balance as of end of period $ — $ 27,964 2021 2020 Premium conversion derivatives Balance as of beginning of period $ — $ 2,714 Value assigned to the underlying derivatives in connection with convertible notes — 831 Revaluation due to convertible note extinguishment — (3,086 ) Change in fair value of premium conversion derivatives — (459 ) Balance as of end of period $ — $ — There were no financial instruments measured on a non-recurring basis for any of the periods presented. Income Taxes The Company utilizes the liability method of accounting for income taxes as required by ASC 740, Income Taxes Property and Equipment Property and equipment, net is recorded at cost and reduced by accumulated depreciation. Depreciation expense is recognized over the estimated useful lives of the assets using the straight-line method. Equipment and furniture are depreciated over a five year estimated useful life. Tangible assets acquired for research and development activities which have alternative use are capitalized and depreciated over the useful life of the acquired asset. Estimated useful lives are periodically reviewed, and when appropriate, changes are made prospectively. When certain events or changes in operating conditions occur, asset lives may be adjusted and an impairment assessment may be performed on the recoverability of the carrying amounts. Maintenance and repairs are charged directly to expense as incurred. Recent Accounting Pronouncements In June 2016, the FASB issued Accounting Standards Update (“ASU”) 2016-13, “ Financial Instruments – Credit Losses” In August 2020, FASB issued ASU 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity which, among other things, provides guidance on how to account for contracts on an entity’s own equity. This ASU eliminates the beneficial conversion and cash conversion accounting models for convertible instruments. It also amends the accounting for certain contracts in an entity’s own equity that are currently accounted for as derivatives because of specific settlement provisions. In addition, this ASU modifies how particular convertible instruments and certain contracts that may be settled in cash or shares impact the diluted EPS computation. The amendments in this ASU are effective for public business entities that meet the definition of a Securities and Exchange Commission (“SEC”) filer, excluding entities eligible to be smaller reporting companies as defined by the SEC, for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. For all other entities, the amendments are effective for fiscal years beginning after December 15, 2023, including interim periods within those fiscal years. The Company is currently evaluating the impact of ASU 2020-06 on its consolidated financial statements. In November 2021, the FASB issued ASU 2021-10, Government Assistance (Topic 832) - Disclosures by Business Entities about Government Assistance, |
Merger
Merger | 12 Months Ended |
Dec. 31, 2021 | |
Merger [Abstract] | |
Merger | 2. Merger On November 5, 2020, the Company completed its merger transaction with Rexahn in accordance with the terms of the Merger Agreement. Immediately after the Merger, there were approximately 7,091,878 shares of the Company’s common stock, par value $0.0001 per share (the “Common Stock”) outstanding (not including 3,749,992 Additional Shares under the Securities Purchase Agreement that were held in escrow subject to final adjustment). The former stockholders and option holders of Private Ocuphire (including the Investors under the Securities Purchase Agreement) owned, or held rights to acquire, in the aggregate approximately 86.6% of the fully-diluted Common Stock, which for these purposes is defined as the outstanding Common Stock, plus outstanding options of the Company, and not including any Additional Shares (the “Fully-Diluted Common Stock”), with the former Rexahn stockholders immediately prior to the Merger owning approximately 13.4% of the Fully-Diluted Common Stock. Pursuant to the Merger Agreement, the number of shares of Common Stock issued to Private Ocuphire’s stockholders for each share of Ocuphire’s common stock outstanding immediately prior to the Merger was calculated using an Exchange Ratio of approximately 1.0565 shares of Common Stock for each share of Private Ocuphire common stock. Immediately following the Merger, the stockholders of Private Ocuphire owned of the outstanding common stock of the Company. The transaction was accounted for as an asset acquisition in accordance with GAAP. Under this method of accounting, Private Ocuphire was deemed to be the accounting acquirer for financial reporting purposes. This determination was primarily based on the facts that, immediately following the Merger: (i) Private Ocuphire’s stockholders owned substantially all of the voting rights in the combined company, (ii) Private Ocuphire designated all, but one, of the members of the initial board of directors of the combined company, and (iii) Private Ocuphire’s senior management holds all key positions in the senior management of the combined company. As a result, as of the closing date of the Merger, the net assets of Rexahn were recorded at their acquisition-date relative fair values in the consolidated financial statements of the Company and the reported operating results prior to the Merger are those of Private Ocuphire. The total purchase price paid in the Merger has been allocated to the net assets acquired and liabilities assumed based on their fair values as of the completion of the Merger. The following summarizes the purchase price paid in the Merger (in thousands, except share and per share amounts): Number of shares of the combined organization owned by the Company’s Pre-Merger stockholders 1,120,800 Multiplied by the fair value per share of REXN’s common stock (1) $ 7.24 Fair value of common stock issued to affect the Merger 8,115 Fair value of warrants and options issued to affect the Merger 768 Transaction costs 1,575 Purchase price $ 10,458 (1) Based on the last reported sale price of the Rexahn’s common stock on the Nasdaq Capital Market on November 5, 2020, the closing date of the Merger, and gives effect to the Reverse Stock Split. The allocation of the purchase price is as follows: Cash acquired $ 2,014 Net assets assumed 68 IPR&D (2) 8,376 Purchase price $ 10,458 (2) Represents the pre-Merger research and development projects of Rexahn which were in-process, but not yet completed, and which the Company may advance post-Merger. This includes the development of RX-3117, RX-0301 and RX-0047. Current accounting standards require that the fair value of IPR&D projects acquired in an asset acquisition with no alternative future use be allocated a portion of the consideration transferred and charged to expense on the acquisition date. The acquired assets did not have outputs or employees. Contingent Value Rights Agreement On November 5, 2020, in connection with the Merger, the Company, Shareholder Representatives Services LLC, as representative of the Rexahn stockholders prior to the Merger, and Olde Monmouth Stock Transfer Co., Inc., as the rights agent, entered into a Contingent Value Rights Agreement (the “CVR Agreement”). Pursuant to the Merger Agreement and the CVR Agreement, Rexahn stockholders of record as of immediately prior to the Effective Time received one contingent value right (“CVR”) for each share of Rexahn Common Stock held. Each CVR entitles such holders to receive, for each calendar quarter (each, a “CVR Payment Period”) during the 15-year period after the Closing (the “CVR Term”), an amount equal to the following: • 90% of all payments received by Rexahn or its affiliates during such CVR Payment Period from or on behalf of BioSense Global LLC (“BioSense”) pursuant to that certain License and Assignment Agreement, dated as of February 25, 2019, by and between BioSense and Rexahn, as amended by Amendment No. 1, dated August 24, 2019, and as further amended by Amendment No. 2, dated March 10, 2020, minus certain permitted deductions; • 90% of all payments received by Rexahn or its affiliates during such CVR Payment Period from or on behalf of Zhejiang HaiChang Biotechnology Co., Ltd. (“HaiChang”) pursuant to that certain Exclusive License Agreement, dated as of February 8, 2020, by and between HaiChang and Rexahn, minus certain permitted deductions; and • 75% of the sum of (i) all cash consideration paid by a third party to Rexahn or its affiliates during the applicable CVR Payment Period in connection with the grant, sale or transfer of rights to Rexahn’s pre-Closing intellectual property (other than a grant, sale or transfer of rights involving a sale or disposition of the post-Merger combined company) that is entered into during the 10-year period after the Closing (“Parent IP Deal”), plus (ii) with respect to any non-cash consideration received by Rexahn or its affiliates from a third party during the applicable CVR Payment Period in connection with any Parent IP Deal, all amounts received by Rexahn and its affiliates for such non-cash consideration at the time such non-cash consideration is monetized by Rexahn or its affiliates, minus (iii) certain permitted deductions. The CVRs are not transferable, except in certain limited circumstances, will not be certificated or evidenced by any instrument, will not accrue interest and will not be registered with the SEC or listed for trading on any exchange. The CVR Agreement will continue in effect until the later of the end of the CVR Term and the payment of all amounts payable thereunder. As of December 31, 2021, $91,000 was paid under the CVR Agreement and was recorded in the other (expense) income, net line item in the condensed consolidated statements of comprehensive loss As of the November 5, 2020, the Merger closing date, and December 31, 2021, no additional milestones under the license agreements subject to the CVR Agreement had been accrued as there were no potential milestones yet considered probable. Former Rexahn Warrants and Stock Options Following the closing of the Merger, 231,433 outstanding, unexercised Rexahn warrants to purchase Common Stock remained outstanding, the majority of which were subsequently repurchased according to the terms of the original warrant agreements. As of December 31, 2021, 66,538 of the Rexahn warrants remained outstanding with exercise prices ranging from $38.40 to $198.00 per share with an average remaining contractual life of 1.9 years. In addition, there were 993 outstanding, unexercised Rexahn stock options to purchase Common Stock upon close of the Merger of which 82 options were outstanding as of December 31, 2021 (see Note 7 – Share-based Compensation). |
Commitments and Contingencies
Commitments and Contingencies | 12 Months Ended |
Dec. 31, 2021 | |
Commitments and Contingencies [Abstract] | |
Commitments and Contingencies | 3. Commitments and Contingencies Apexian Sublicense Agreement On January 21, 2020, the Company entered into a sublicense agreement with Apexian Pharmaceuticals, Inc., pursuant to which it obtained exclusive worldwide patent and other intellectual property rights. In exchange for the patent and other intellectual rights, the Company agreed to certain milestone and royalty payments on future sales (See Note 8 — Apexian Sublicense Agreement). As of December 31, 2021, there was sufficient uncertainty with regard to both the outcome of the clinical trials and the ability to obtain sufficient funding to support any of the cash milestone payments under the sublicense agreement, and as such, no liabilities were recorded related to the sublicense agreement. Facility Leases In May 2019, the Company entered into a short-term non-cancellable facility lease (the “Lease”) for its operations and headquarters for a seven-month term beginning in June 2019. The Lease, as amended, has extended the term to December 31, 2022. Additionally, Ocuphire leased office space in Rockville, Maryland through June 30, 2021 previously occupied by Rexahn (the “Rexahn Lease”). The Lease and the Rexahn Lease qualified for the short-term lease exception under ASC 842, Leases Issuance of Settlement Shares On May 6, 2021, the Company issued 350,000 shares of common stock of the Company to three accredited investors pursuant to a settlement agreement, dated May 6, 2021, in exchange for a release of potential claims. The fair value of the share settlement of $1,614,000 was based on the closing Ocuphire stock price for that day. The fair value of the share settlement was recorded in general and administrative expenses in the accompanying consolidated statements of comprehensive loss. Other In the ordinary course of business, from time to time, the Company may be subject to a broad range of claims and legal proceedings that relate to contractual allegations, patent infringement and other claims. In addition, the Company from time to time may be potentially committed to reimburse third parties for costs incurred associated with business development related transactions upon the achievement of certain milestones. The Company establishes accruals when applicable for matters and commitments which it believes losses are probable and can be reasonably estimated. To date, no loss contingency for such matters and potential commitments have been recorded. Although it is not possible to predict with certainty the outcome of these matters or potential commitments, the Company is of the opinion that the ultimate resolution of these matters and potential commitments will not have a material adverse effect on its results of operations or financial position. |
Supplemental Balance Sheet Info
Supplemental Balance Sheet Information | 12 Months Ended |
Dec. 31, 2021 | |
Supplemental Balance Sheet Information [Abstract] | |
Supplemental Balance Sheet Information | 4. Supplemental Balance Sheet Information Prepaid and Other Assets Prepaid and other assets consist of the following (in thousands): December 31, 2021 2020 Prepaids $ 1,243 $ 1,243 Other 71 26 Total prepaids and other assets $ 1,314 $ 1,269 Property and Equipment, net Property and equipment held for use by category are presented in the following table (in thousands): December 31, 2021 2020 Equipment $ 20 $ 20 Furniture 5 5 Total property and equipment 25 25 Less accumulated depreciation (15 ) (11 ) Property and equipment, net $ 10 $ 14 Depreciation expense was $4,000 and $8,000 for the years ended December 31, 2021 and 2020, respectively. Accrued Expenses Accrued expenses consist of the following (in thousands): December 31, 2021 2020 R&D services and supplies $ 1,081 $ 1,440 Payroll 488 320 Professional services 84 186 Other 80 25 Total $ 1,733 $ 1,971 Short-Term Loan The Company entered into an unsecured short-term loan (the “Loan”) agreement in the amount of $0.6 million in November 2021 related to financing an insurance policy. The Loan is payable in six monthly installments of $108,000 beginning in December 2021. The Loan has an annual interest rate of 5.5% per annum. Interest expense in the amount of $2,000 was recognized in connection with the Loan during the year ended December 31, 2021. |
Convertible Notes
Convertible Notes | 12 Months Ended |
Dec. 31, 2021 | |
Convertible Notes [Abstract] | |
Convertible Notes | 5. Convertible Notes The Company entered into a series of unsecured convertible note financings (the “Convertible Notes”) with certain investors beginning on May 25, 2018. The total issuance of Convertible Notes amounted to $8.5 million (see Note 6 – Related Party Transactions). On November 4, 2020, all of Ocuphire’s outstanding Convertible Notes were converted into 977,128 shares of Ocuphire common stock as adjusted for the Exchange Ratio in connection with the completion of the Merger. The conversion was accounted for as a debt extinguishment given the bifurcation of the embedded premium conversion derivatives. The fair value of the newly issued common shares associated with the Convertible Notes conversion relative to the carrying value of the debt and fair value of premium conversion derivatives on the conversion date was $2.7 million lower and was recorded largely as a gain on note extinguishment in the amount of $2.4 million in the accompanying consolidated statements of comprehensive loss with the remaining portion of $0.3 million differential being recorded as additional paid-in capital for the portion attributed to related parties. Prior to the conversion of the Convertible Notes, the Company amended the Convertible Notes (the “Conversion Agreement”) on June 8, 2020. Under the Conversion Agreement, upon such date selected by the Company following Rexahn’s receipt of the required Rexahn stockholder vote and prior to the effectiveness of the Merger, each Convertible Note would automatically and without any action required by any purchaser or the Company be cancelled and, simultaneously with such cancellation, would convert into that number of fully paid and non-assessable shares of the Company’s common stock that was equal to 175% times the outstanding principal and accrued but unpaid interest (Note Value) divided by the conversion price (the “Conversion Price”), rounded to the nearest whole share. The Conversion Price had the meaning of the per share price resulting from the quotient of (1) $100,000,000 less the aggregate amount of 175% times the Note Value of all of the Convertible Notes divided by (2) the fully diluted shares (the “Fully Diluted Shares”). Fully Diluted Shares had the meaning of: (1) all of the issued outstanding shares of the Company’s common stock; and (2) the aggregate number of shares of the Company’s common stock reserved for issuance under all outstanding options or other awards under equity incentive plans of the Company in effect as of such date of determination. The addition of the new conversion feature under the Conversion Agreement represented a substantial modification to the Convertible Notes, and as such, the Company recorded the modification as a note extinguishment. On the modification date, the fair value of the Convertible Notes (inclusive of the embedded features) was $1.3 million lower upon modification than the aggregate of the carrying value of the Convertible Notes and the fair value of the embedded features; the difference was recorded as a gain on note extinguishment in the accompanying consolidated statements of comprehensive loss for the year ended December 31, 2020. Lastly, an increase to additional paid-in capital in the amount of $1.0 million was recorded in connection with the Conversion Agreement to account for the excess of the Convertible Notes’ fair value over the aggregate value of outstanding note principal, accrued interest and fair value of the premium conversion derivatives upon execution of the Conversion Agreement. The Convertible Notes accrued interest at a rate of 8% per annum, calculated on a 365-day year basis. Interest expense on principal during the year ended December 31, 2020 was $0.5 million. Previous to the Conversion Agreement, the outstanding principal of, and accrued interest on the Convertible Notes were payable on demand, in the absence of the Merger closing discussed above, at any time as of the first to occur of (i) September 30, 2020 or (ii) an event of default (each defined by the Convertible Notes as a Payoff Event). If, prior to a Payoff Event, the Company (i) completed an initial public offering (“IPO”), (ii) completed a change in control (“CIC”), (iii) completed a sale and issuance of its capital stock resulting in gross proceeds to the Company of at least $5 million (“Qualified Financing”), or (iv) completed a reverse merger transaction (Reverse Merger), then the outstanding principal of, and accrued but unpaid interest on the Convertible Notes would have automatically converted upon the earliest of such events to occur as follows: • IPO: • CIC: • Qualified Financing • Reverse Merger (excluding close of Merger with Rexahn) The Company was not permitted to prepay the Convertible Notes prior to a Payoff Event. The Convertible Notes contained default provisions, and when triggered, the holders of the Convertible Notes could have immediately accelerated payment of the Convertible Notes and the outstanding principal and interest would have become payable immediately. During a period of default, interest would have been assessed at a 12% per annum rate. Redemption Features The Company determined that all of the conversion provisions, except for the conversion provision upon Merger close, were redemption features that qualified as embedded derivatives. The qualifying embedded derivatives were collectively separated from their debt host upon the issuance of the Convertible Notes. The bifurcation of the embedded derivatives from the debt host resulted in a discount to the Convertible Notes in the amount of $0.8 million during the year ended December 31, 2020. The embedded derivatives were accounted for separately on a fair market value basis. The fair value of the derivatives was $2.7 million at December 31, 2020 and was included in the premium conversion derivatives line item on the accompanying consolidated balance sheets. There were no outstanding premium conversion derivatives as of December 31, 2021 given the conversion of the Convertible Notes. The Company recorded the fair value changes of the premium conversion derivatives while outstanding to fair value change in derivative and warrant liabilities in the accompanying consolidated statements of comprehensive loss which amounted to a benefit of $0.5 million during the year ended December 31, 2020. The Company recorded a discount to the Convertible Notes, attributed to both third party costs in connection with the note extinguishments and note issuance costs, of $8,000 during the year ended December 31, 2020. The note discounts were amortized to interest expense over the term of the Convertible Notes using the straight-line method which approximates the effective interest method and amounted to $0.9 million during the year ended December 31, 2020. |
Related Party Transactions
Related Party Transactions | 12 Months Ended |
Dec. 31, 2021 | |
Related Party Transactions [Abstract] | |
Related Party Transactions | 6. Related Party Transactions CVR Agreement The Company entered into a CVR Agreement with the former Rexahn stockholders. See Note 2 – Merger. Convertible Notes with Related Parties The Company entered into Convertible Notes with certain investors beginning on May 25, 2018. Through December 31, 2021, Convertible Notes in the principal aggregate amount equal to $0.7 million were issued to four board members and to two officers, one of which was also a board member of the Company. On November 4, 2020, all of Ocuphire’s outstanding Convertible Notes were converted into Ocuphire common, see Note 5 – Convertible Notes. Apexian Sublicense Agreement On January 21, 2020, as amended on June 4, 2020, the Company entered into a sublicense agreement with Apexian Pharmaceuticals, Inc. (“Apexian”) and issued a total of 843,751 shares of common stock to Apexian and to certain affiliates of Apexian. See Note 8 – Apexian Sublicense Agreement. Pre-Merger Financing Five directors of Private Ocuphire and one director of Rexahn participated in the Pre-Merger Financing, investing an aggregate of $300,000. Following the closing of the Merger, these directors received 17,729 Converted Initial Shares, 53,189 Converted Additional Shares, 80,366 Series A Warrants and 9,444 Series B Warrants. See Note 9 – Stockholders’ Equity (Deficit). Waiver Agreements Six directors of the Company signed Waiver Agreements, waiving certain reset provisions financing restrictions. See Note 9 – Stockholders’ Equity (Deficit). |
Share-based Compensation
Share-based Compensation | 12 Months Ended |
Dec. 31, 2021 | |
Share-based Compensation [Abstract] | |
Share-based Compensation | 7. Share-based Compensation Share-based compensation expense was included in general and administrative and research and development costs as follows in the accompanying statements of comprehensive loss for the periods indicated below (in thousands): December 31, 2021 2020 General and administrative $ 1,116 $ 675 Research and development 798 831 Total share-based compensation $ 1,914 $ 1,506 Ocuphire Stock Options Inducement Plan On February 22, 2021, the Company adopted the Ocuphire Pharma, Inc. Inducement Plan (the “Plan”), pursuant to which the Company reserved 325,258 shares of its common stock to be used exclusively for grants of awards to individuals who were not previously employees or directors of the Company, as an inducement material to the individual’s entry into employment with the Company within the meaning of Rule 5635(c)(4) of the Nasdaq Listing Rules. 2020 Equity Incentive Plan The stockholders of the Company approved the 2020 Equity Incentive Plan (the “2020 Plan”) for share-based awards. The 2020 Plan became effective on November 5, 2020. Under the 2020 Plan, (i) 1,000,000 new shares of common stock are reserved for issuance and (ii) up to 70,325 additional shares of common stock may be issued, consisting of (A) shares that remain available for the issuance of awards under prior equity plans and (B) shares of common stock subject to outstanding stock options or other awards covered by prior equity plans that have been cancelled or expire on or after the date that the 2020 Plan became effective. The 2020 Plan permits the grant of incentive and nonstatutory stock options, appreciation rights, restricted stock, restricted stock units, performance stock and cash awards, and other share‑based awards 2018 Equity Incentive Plan Prior to the 2020 Plan, the Company had adopted a 2018 Equity Incentive Plan (the “2018 Plan”) in April 2018 under which 1,175,000 shares of the Company’s common stock were reserved for issuance to employees, directors and consultants. Upon the effective date of the 2020 Plan, no additional shares were available for issuance under the 2018 Plan During the years ended December 31, 2021 and 2020, 420,300 and 830,167 stock options were granted to newly-hired officers, directors, employees and consultants (as adjusted for the Exchange Ratio), respectively, generally vesting over an immediate to forty-eight (48) month period. The Company recognized $1.8 million and $1.4 million in share-based compensation expense related to stock options during the years ended December 31, 2021 and 2020, respectively. During the years ended December 31,2021 and 2020, 73,442 and 40,672 stock options were exercised, respectively, with an intrinsic value of $345,000 and $175,000, respectively. The following table summarizes the Company’s stock option plan activity: Number of Options Weighted Average Exercise Price Weighted Average Remaining Contractual Term (years) Aggregate Intrinsic Value(1) (in thousands) Outstanding at December 31, 2019 1,037,705 $ 1.06 9.20 $ 1,374 Granted 830,167 $ 3.50 — — Exercised (40,672 ) $ — — — Forfeited/Cancelled (43,002 ) $ — — — Outstanding at December 31, 2020 1,784,198 $ 2.17 8.87 $ 7,744 Granted 420,300 $ 5.72 — — Exercised (73,442 ) $ — — — Forfeited/Cancelled (34,220 ) $ — — — Outstanding at December 31, 2021 2,096,836 $ 2.97 8.20 $ 2,795 Vested and exercisable at December 31, 2021 1,281,263 $ 1.88 7.63 $ 2,370 (1) The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying options and the fair value of our common stock as of December 31, 2021 and 2020 of $3.73 and $6.49 per share (as adjusted for the Exchange Ratio), respectively. The weighted average fair value per share of options granted during the years ended December 31, 2021 and 2020 was $4.36 and $3.92, respectively. The Company measures the fair value of stock options with service‑based and performance‑based vesting criteria to employees, directors, consultants and directors on the date of grant using the Black‑Scholes option pricing model. The Company does not have history to support a calculation of volatility and expected term. As such, the Company has used a weighted‑average volatility considering the volatilities of several guideline companies. For purposes of identifying similar entities, the Company considered characteristics such as industry, length of trading history, and stage of life cycle. The assumed dividend yield was based on the Company’s expectation of not paying dividends in the foreseeable future. The average expected life of the options was based on the contractual term for agreements that allow for exercise of vested options through the end of the contractual term upon termination of continuous service, and for all other agreements, was based on the mid‑point between the vesting date and the end of the contractual term according to the “simplified method” as described in Staff Accounting Bulletin 110. The risk‑free interest rate is determined by reference to implied yields available from U.S. Treasury securities with a remaining term equal to the expected life assumed at the date of grant. The Company records forfeitures when they occur. The weighted‑average assumptions used in the Black‑Scholes option‑pricing model are as follows during the years ended December 31, 2021 and 2020: 2021 2020 Expected stock price volatility 98.1 % 86.8 % Expected life of options (years) 5.8 7.2 Expected dividend yield 0 % 0 % Risk free interest rate 0.9 % 0.6 % During the years ended December 31, 2021 and 2020, 468,301 and 379,576 stock options vested (as adjusted for the Exchange Ratio), respectively. The weighted average fair value per share of options vesting during the years ended December 31, 2021 and 2020 was $3.49 and $2.77, respectively. During the years ended December 31, 2021 and 2020, 34,220 and 43,002 stock options were forfeited, respectively. As of December 31, 2021, 890,542 shares in the aggregate were available for future issuance under the 2020 Plan and Inducement Plan. Unrecognized share‑based compensation cost was $2.4 million as of December 31, 2021. The unrecognized share‑based expense is expected to be recognized over a weighted average period of 1.1 years. Ocuphire Restricted Stock Awards On November 11, 2020, the Company granted 40,000 restricted stock awards (“RSAs”) that vested on January 8, 2021. There were no RSAs granted during the years ended December 31, 2021. The share-based compensation expense attributed to the RSAs during each of the years ended December 31, 2021 and 2020 was $22,000 and $0.1 million, respectively. A summary of RSA activity is as follows for the years ended December 31, 2021 and 2020: Number of Shares Non-vested at December 31, 2019 — Granted 40,000 Vested — Non-vested at December 31, 2020 40,000 Granted — Vested (40,000 ) Non-vested at December 31, 2021 — Common Stock Issued for Services The Company granted stock for services in the amount of 21,414 common shares to two board members who elected to receive their board retainers in the form of stock for services performed during the year ended December 31, 2021. The share-based compensation related to these services amounted to $108,000 during the year ended December 31, 2021. Former Rexahn Options Following the closing of the Merger, 123 unexercised and vested options to purchase Common Stock granted under the Rexahn Pharmaceuticals Stock Option Plan, as amended (the “Rexahn 2003 Plan”, and together with the Rexahn 2013 Plan, the “Prior Plans”) were outstanding. As of December 31, 2021, 82 of the former Rexahn options remained outstanding. During the year ended December 31, 2021, 41 of the former Rexahn options expired. The exercise price related to the outstanding options granted under the Prior Plans was $182.40 per share with an average remaining contractual life of 0.5 years. |
Apexian Sublicense Agreement
Apexian Sublicense Agreement | 12 Months Ended |
Dec. 31, 2021 | |
Apexian Sublicense Agreement [Abstract] | |
Apexian Sublicense Agreement | 8. Apexian Sublicense Agreement On January 21, 2020, as amended on June 4, 2020, the Company entered into a sublicense agreement (the “Sublicense Agreement”) with Apexian, pursuant to which it obtained exclusive worldwide patent and other intellectual property rights that constitute a Ref-1 Inhibitor program relating to therapeutic applications to treat disorders related to ophthalmic and diabetes mellitus conditions. The lead compound in the Ref-1 Inhibitor program is APX3330, which the Company intends to develop as an oral pill therapeutic to treat diabetic retinopathy and diabetic macular edema initially, and potentially later to treat wet age-related macular degeneration. In connection with the Sublicense Agreement, the Company issued a total of 843,751 shares of its common stock to Apexian and to certain affiliates of Apexian. The share issuance transaction was recorded in the amount of $2.1 million as IPR&D expense for the year ended December 31, 2020 based on the fair market value of the common shares issued since no processes or activities that would constitute a “business” were acquired and none of the rights and underlying assets acquired had alternative future uses or reached a stage of technological feasibility. Additionally, in accordance with the Sublicense Agreement, the Company was required to pay any balance remaining related to $0.4 million of Ref-1 Inhibitor program costs to Apexian following the Company’s listing on a major stock exchange. In December 2020, the Company paid the remaining Ref-1 Inhibitor program cost balance to Apexian in the amount of $0.3 million following the close of the Merger. The Ref-1 Inhibitor program costs were recorded as research and development expenses in the accompanying statements of comprehensive loss The Company also agreed to make one-time milestone payments under the Sublicense Agreement for each of the first ophthalmic indication and the first diabetes mellitus indication for the Development and Regulatory milestones, and once for each of the Sales milestones. These milestone payments include (i) payments for specified developmental and regulatory milestones (including completion of the first Phase 2 trial and the first Phase 3 pivotal trial in the United States, and filing and achieving regulatory approval from the FDA for the first New Drug Application for a compound) totaling up to $11 million in the aggregate and (ii) payments for specified sales milestones of up to $20 million in the aggregate, which net sales milestone payments are payable once, upon the first achievement of such milestone. Lastly, the Company also agreed to make a royalty payment equal to a single-digit percentage of its net sales of products associated with the covered patents under the Sublicense Agreement. If it is not terminated pursuant to its terms, the Sublicense Agreement shall remain in effect until expiration of the last to expire of the covered patents. None of the milestone or royalty payments, outside of the Ref-1 Inhibitor program cost reimbursement, were triggered or deemed probable as of December 31, 2021. |
Stockholder Equity (Deficit)
Stockholder Equity (Deficit) | 12 Months Ended |
Dec. 31, 2021 | |
Stockholder Equity (Deficit) [Abstract] | |
Stockholder Equity (Deficit) | 9. Stockholder Equity (Deficit) At-The-Market Program On February 4, 2021, Ocuphire filed a Form S-3 shelf registration under the Securities Act of 1933 which was declared effective by the SEC on February 12, 2021 (the “2021 Shelf”) under which the Company may offer and sell, from time to time in its sole discretion, securities having an aggregate offering price of up to $125 million. In connection with the 2021 Shelf, on March 11, 2021, Ocuphire entered into a Sales Agreement with JonesTrading Institutional Services LLC (“JonesTrading”) under which the Company may offer and sell, from time to time at its sole discretion, to or through JonesTrading, acting as agent and/or principal, shares of its common stock having an aggregate offering price of up to $40 million (the “2021 ATM”). During the year ended December 31, 2021, common shares were sold under the 2021 ATM for gross proceeds in the amount of $13.5 million before deducting issuance expenses, including the placement agent’s fees, legal and accounting expenses, in the amount of $0.4 million. Registered Direct Offering On June 4, 2021, the Company entered into a placement agency agreement with A.G.P./Alliance Global Partners (“AGP”). Pursuant to the terms of the placement agency agreement, AGP on June 8, 2021 sold an aggregate of shares of the Company’s common stock and warrants to purchase shares of the Company’s common stock (the “RDO Warrants”) at an offering price of $4.875 per one share and RDO Warrants, for gross proceeds of $15.0 million, before AGP’s fees and related offering expenses in the amount of $1.1 million. The proceeds were allocated between the relative fair values of common stock and warrants at the sale date. The purchase agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company, other obligations of the parties and termination provisions. The offering of the Securities (the “Registered Direct Offering”) was made pursuant to the Company’s 2021 Shelf. The RDO Warrants have an exercise price of $6.09 per share, are exercisable from the initial issuance date of June 8, 2021, and will expire following the initial issuance date. The fair value of the RDO Warrants was determined to be $6.4 million based on the Black-Scholes pricing model. Input assumptions used were as follows: a risk-free interest rate of ; expected volatility of ; expected life of ; expected dividend yield of ; and the underlying fair market of the common stock. The RDO Warrants were classified in stockholders’ equity (deficit) after considering indexation and settlement rules of ASC 480 and 815 that require that the number of issuable shares are fixed and determinable and other conditions required for equity treatment. As of December 31, 2021, RDO Warrants were outstanding. Subject to limited exceptions, a holder of a RDO Warrant will not have the right to exercise any portion of its RDO Warrants if the holder, together with its affiliates, would beneficially own in excess of (or, at the election of a holder prior to the date of issuance, ) of the number of shares of the Company’s common stock outstanding immediately after giving effect to such exercise; provided, however, that upon prior notice to the Company, the holder may increase or decrease the beneficial ownership limitation, provided further that in no event shall the beneficial ownership limitation exceed 9.99%. Pre-Merger Financing Waiver Agreements Effective February 3, 2021, each investor that invested in the Pre-Merger Financing (as defined below) entered into a Waiver Agreement with the Company (collectively, the “Waiver Agreements”). Pursuant to the Waiver Agreements, the investors and the Company agreed to waive certain rights, finalize the exercise price and number of Series A Warrants and Series B Warrants, eliminate certain financing restrictions, extend the term of certain leak-out agreements, and, in the case of certain investors, grant certain registration rights for the shares underlying the warrants. The Waiver Agreements provide for the elimination of the full ratchet anti-dilution provisions, contained in the Series A Warrants (as certain of the anti-dilution provisions had previously caused liability accounting treatment for the Series A Warrants). Upon the effective date of the Waiver Agreements, the Series A Warrants were reclassified to equity. Pursuant to the Waiver Agreements, the number of shares underlying all of the Series B Warrants was fixed to in the aggregate with respect to all investors, eliminating any future resets. Securities Purchase Agreement On June 17, 2020, Ocuphire, Rexahn and certain investors entered into a Securities Purchase Agreement, which was amended and restated in its entirety on June 29, 2020 (as amended and restated, the “Securities Purchase Agreement”). Pursuant to the Securities Purchase Agreement, the investors invested a total of $21.15 million in cash, including $300,000 invested by five directors of Private Ocuphire and one director of Rexahn, upon closing of the Merger (the “Pre-Merger Financing”). Pursuant to the Pre-Merger Financing, (i) Ocuphire issued and sold to the investors shares of Private Ocuphire common stock (the “Initial Shares”) which converted pursuant to the exchange ratio in the Merger into an aggregate of approximately 1,249,996 shares (the “Converted Initial Shares”) of common stock, (ii) Ocuphire deposited into escrow, for the benefit of the Investors, additional shares of Private Ocuphire common stock (the “Additional Shares”) which converted pursuant to the exchange ratio in the Merger into an aggregate of approximately 3,749,992 shares of common stock (the “Converted Additional Shares”), which Converted Additional Shares were delivered (or became deliverable) to the investors on November 19, 2020, and (iii) the Company agreed to issue to each investor on the tenth Series A Warrants The Series A Warrants were issued on November 19, 2020 at an initial exercise price of $4.4795 per share, were immediately exercisable upon issuance and have a term of five years from the date of issuance. The Series A Warrants are exercisable for 5,665,838 shares of common stock in the aggregate (without giving effect to any limitation on exercise contained therein) and were outstanding as of December 31, 2021. The Series A Warrants provide that, until the second anniversary of the date on which all shares of common stock issued and issuable to the investors may be sold without restriction or limitation pursuant to Rule 144, if Ocuphire publicly announces, issues or sells, enters into a definitive, binding agreement pursuant to which Ocuphire is required to issue or sell or is deemed, pursuant to the provisions of the Series A Warrants, to have issued or sold, any shares of common stock for a price per share lower than the exercise price then in effect, subject to certain limited exceptions, then the exercise price of the Series A Warrants will be reduced to such lower price per share. Further, on each Reset Date (as defined below under Series B Warrants ) the Series A Warrants will be adjusted downward (but not increased) such that the exercise price thereof becomes 120% of the Reset Price (as defined below), and the number of shares underlying the Series A Warrants will be increased (but not decreased) to the quotient of (a) (i) the exercise price in effect prior to such Reset (as defined below under Series B Warrants) multiplied by (ii) the number of shares underlying the Series A Warrants prior to the Reset divided by (b) the resulting exercise price. In addition, the exercise price and the number of shares of Common Stock issuable upon exercise of the Series A Warrants will also be subject to adjustment in the event of any stock splits, dividends or distributions or other similar transactions. The Series A Warrants were initially accounted for and classified as liabilities upon close of the Merger through the date of the Waiver Agreements given that certain price reset provisions existed that cannot be used for a fair valuation under a fixed for fixed settlement scenario required for equity balance sheet classification. A Monte Carlo simulation model was used to estimate the aggregate fair value of the Series A Warrants. Input assumptions used were as follows: risk-free interest rate 0.4%; expected volatility of 83.6%; expected life of 5 years; and expected dividend yield zero percent. The underlying stock price used was the market price as quoted on Nasdaq as of November 19, 2020. The aggregate fair value of the Series A Warrants of $25.8 million upon issuance was recorded as a long-term liability on the accompanying consolidated balance sheets. The amount by which the aggregate fair value of the Series A Warrants exceeded the $21.15 million gross proceeds from the Pre-Merger Financing, or $4.7 million, was recorded as day-one interest on the accompanying consolidated statements of comprehensive loss during the year ended December 31, 2020. The Company recorded the fair value change of the Series A Warrants in the amount of $2.1 million to the fair value change in derivative and warrant liabilities line item on the accompanying consolidated statements of comprehensive loss for the year ended December 31, 2020. Upon the February 3, 2021 effective date of the Waiver Agreements, the Series A Warrants were reclassified to equity. A final fair valuation of the Series A Warrants was performed utilizing a Black Scholes model to estimate the aggregate fair value of the Series A Warrants prior to being re-classified as equity. Input assumptions used were as follows: risk-free interest rate 0.4%; expected volatility of 86.6%; expected life of 4.8 years; and expected dividend yield zero percent. The underlying stock price used was the market price as quoted on Nasdaq as of February 3, 2021, the effective date of the Waiver Agreement. The fair value change of the Series A Warrants was $33.8 million and was recorded to the fair value change in warrant liabilities and premium conversion derivatives line item on the accompanying consolidated statements of comprehensive loss for the year ended December 31, 2021. As a result of the reclassification to equity, the Series A Warrants are no longer subject to remeasurement. Series B Warrants The Series B Warrants have an exercise price of $0.0001, were exercisable upon issuance and will expire on the day following the later to occur of (i) the Reservation Date (as defined therein), and (ii) the date on which the investor’s Series B Warrants have been exercised in full (without giving effect to any limitation on exercise contained therein) and no shares remain issuabl e thereunder. The Series shares of Common Stock, as of the effective date of the Waiver Agreement, in the aggregate (without giving effect to any limitation on exercise contained therein). In April 2021, investors exercised Series B Warrants for a total of 1,629,634 shares. As of December 31, 2021, 78,700 Series B warrants were outstanding. Prior to the Waiver Agreements, the Series B warrants were initially exercisable for 665,836 shares of Common Stock in the aggregate (without giving effect to any limitation on exercise contained therein). Additionally, prior to the Waiver Agreement, the number of Series B were subject to adjustment whereby every ninth Six Month Six Month The Series B Warrants were accounted for and classified as equity on the accompanying consolidated balance sheets. Other In connection with the Pre-Merger Financing, the Company incurred issuance costs in the amount of $1.8 million which included (i) a placement agent cash fee of $1.6 million and (ii) legal and other fees of $0.2 million. Issuance costs in the amount of $0.7 million attributed to the Series A Warrants were recorded as interest expense on the accompanying consolidated statements of comprehensive loss for the year ended December 31, 2020 and $1.1 million was recorded as an offset to additional paid-in capital. |
Collaboration and License Agree
Collaboration and License Agreements | 12 Months Ended |
Dec. 31, 2021 | |
Collaboration and License Agreements [Abstract] | |
Collaboration and License Agreements | 10. Collaboration and License Agreements BioSense License and Assignment Agreement On March 10, 2020, pre-Merger, Rexahn entered into an amendment to its collaboration and license agreement, (as amended, the “BioSense License and Assignment Agreement”) with BioSense to advance the development and commercialization of RX-3117 for all human uses in the Republic of Singapore, China, Hong Kong, Macau, and Taiwan (the “BioSense Territory”). Under the terms of the BioSense License and Assignment Agreement, the Company (i) granted BioSense an exclusive license to develop and commercialize pharmaceutical products containing RX-3117 as a single agent for all human uses in the BioSense Territory and (ii) assigned and transferred all of the former Rexahn patents and patent applications related to RX-3117 in the BioSense Territory. The upfront payment consisted of an aggregate of $1,650,000, of which $1,550,000 was paid to Rexahn prior to the Merger.During the year ended December 31, 2021, the Company satisfied a performance obligation for the $100,000 payment that was remaining and recorded this amount as collaboration revenue. Under the BioSense License and Assignment Agreement, the Company is eligible to receive additional milestone payments in an aggregate of up to $84,500,000 upon the achievement of development, regulatory and commercial goals and will also be eligible to receive tiered royalties at low double-digit rates on annual net sales in the BioSense Territory. The Company determined that none of the milestone payments under the BioSense License and Assignment Agreement were probable of payment as of December 31, 2021, and as a result, no revenue related to the milestones was recognized as the achievement of events entitling the Company to any milestone payments were highly susceptible to factors outside of the Company’s control. Future sales-based royalties related to the exclusive license to develop RX-3117 will be recognized in the period the underlying sales transaction occurs. Payments received under the BioSense License and Assignment Agreement are subject to the CVR Agreement described in Note 2 – Merger. Processa License Agreement On June 16, 2021, the Company entered into a license agreement (the “Processa License Agreement”) with Processa Pharmaceuticals, Inc. (“Processa”), pursuant to which the Company has agreed to grant Processa an exclusive license to develop, manufacture and commercialize RX-3117 globally, excluding the BioSense Territory. As consideration for the Processa License Agreement, the Company received an upfront payment in July 2021 consisting of 44,689 shares of Processa common stock with a fair value of $289,000 (at the contract date) and a $200,000 cash payment.The Company is restricted from selling the Processa common stock for a period of one year ending June 16, 2022. As additional consideration, Processa will make payments to the Company upon the achievement of certain development and regulatory milestones, which primarily consist of dosing a patient in pivotal trials or having a drug indication approved by a regulatory authority in the United States or another country. In addition, Processa will pay the Company mid-single-digit royalties based on annual sales under the license and will make one-time sales milestone payments based on the achievement during a calendar year of certain thresholds for annual sales. Processa is also required to give the Company 32% of any milestone payments received based on any sub-license agreement Processa may enter into with respect to the Processa License Agreement.The Company determined that none of the milestone payments under the Processa License Agreement were probable of payment as of December 31, 2021, and as a result, no revenue related to the milestones was recognized, as the achievement of events entitling the Company to any milestone payments were highly susceptible to factors outside of the Company’s control. Processa is required to use commercially reasonable efforts, at its sole cost and expense, to conduct development activities in one or more countries, including meeting specific diligence milestones that consist of: (i) first patient administered drug in a clinical trial of a licensed product prior to the three (3) year anniversary of the effective date; and (ii) first patient administered drug in a pivotal clinical trial of a licensed product or first patient administered drug in a clinical trial for a second indication of a licensed product prior to the five (5) year anniversary of the effective date. Either party may terminate the agreement in the event of a material breach of the agreement that has not been cured following written notice and a 120-day opportunity to cure such breach, and Processa may terminate the agreement for any reason upon 120 days prior written notice to Ocuphire. As of December 31, 2021, the Company has fulfilled its performance obligations with respect to the upfront payment under the Processa License Agreement and has recognized the associated licensing revenue in connection with the payment. Payments received under the Processa License Agreement will be subject to the CVR Agreement described in Note 2 – Merger. |
Net loss per share
Net loss per share | 12 Months Ended |
Dec. 31, 2021 | |
Net loss per share [Abstract] | |
Net loss per share | 11. Net loss per share Basic loss per share of common stock is computed by dividing net loss by the weighted average number of shares of common stock outstanding during the period. Diluted earnings or loss per share of common stock is computed similarly to basic earnings or loss per share except the weighted average shares outstanding are increased to include additional shares from the assumed exercise of any common stock equivalents, if dilutive. The Company’s warrants, convertible notes, restricted stock awards and stock options while outstanding are considered common stock equivalents for this purpose. Diluted earnings is computed utilizing the treasury method for the warrants, restricted stock and stock options. No incremental common stock equivalents were included in calculating diluted loss per share because such inclusion would be anti-dilutive given the net loss reported for the periods presented. The following potential common shares were not considered in the computation of diluted net loss per share as their effect would have been anti-dilutive for the year end periods presented below: 2021 2020 Series A, Series B and RDO warrants 7,282,999 6,331,674 Stock options 2,096,836 1,784,198 Restricted stock awards including pending issuances of stock for services 6,970 40,000 Former Rexahn warrants 66,538 66,538 Former Rexahn options 82 123 |
Income Taxes
Income Taxes | 12 Months Ended |
Dec. 31, 2021 | |
Income Taxes [Abstract] | |
Income Taxes | 12. Income Taxes The effective tax rate for the years ended December 31, 2021 and 2020 was zero percent. A reconciliation of income tax computed at the statutory federal income tax rate to the provision (benefit) for income taxes included in the accompanying statements of comprehensive loss is as follows for the years ended December 31, 2021 and 2020: 2021 2020 Income tax (benefit) provision at federal statutory rate (21.0 )% (21.0 )% Valuation allowance 11.9 13.8 State income tax, net of federal benefit (4.8 ) (4.7 ) Acquired in-process research and development expense — 8.8 Warrants 15.3 7.6 Convertible notes — (3.3 ) Stock options (0.1 ) (0.1 ) Research and development (1.1 ) (1.1 ) Other (0.2 ) — Effective tax rate — % — % Significant components of the Company’s deferred tax assets and liabilities are summarized in the tables below as of December 31, 2021 and 2020: 2021 2020 Deferred tax assets: Federal and state operating loss carryforwards $ 19,244 $ 3,351 Acquired intangibles 547 547 Organizational costs 7 8 Other 18 — Share-based compensation 811 466 Research and development 1,035 275 Subtotal 21,662 4,647 Valuation allowance (21,662 ) (4,647 ) Total deferred tax assets, net of valuation allowance — — Deferred tax liabilities: Total deferred tax liabilities — — Net deferred tax assets $ — $ — As of December 31, 2021 and 2020, the Company had gross deferred tax assets of approximately $21.7 million and $4.6 million, respectively. Realization of the deferred assets is primarily dependent upon future taxable income, if any, the amount and timing of which are uncertain. The Company has had significant pre‑tax losses since its inception. The Company has not yet generated revenues and faces significant challenges to becoming profitable. Accordingly, the net deferred tax assets have been fully offset by a valuation allowance of $21.7 million and $4.6 million as of December 31, 2021 and 2020, respectively. U.S. net deferred tax assets will continue to require a valuation allowance until the Company can demonstrate their realizability through sustained profitability or another source of income. As of December 31, 2021 and 2020, the tax effect of the Company’s federal net operating loss carryforwards was approximately $15.7 million and $2.7 million, respectively. The Company had federal research credit carryforwards as of December 31, 2021 and 2020 of approximately $1.0 million and $0.3 million, respectively. The federal net operating loss carryforwards will not expire and the tax credit carryforwards will begin to expire in 2040 if not utilized. As of December 31, 2021 and 2020, the Company had state net operating loss carryforwards with a tax effect of approximately $3.6 million and $0.6 million, respectively. The Company did not have any state research credit carryforwards as of December 31, 2021 and 2020. The state net operating loss carryforwards will begin to expire in 2028. Utilization of the net operating loss carryforwards and credits may be subject to a substantial annual limitation due to the ownership change limitations provided by Section 382 and Section 383 of the Internal Revenue Code of 1986, as amended, and similar state provisions. Generally, in addition to certain entity reorganizations, the limitation applies when one or more “5-percent shareholders” increase their ownership, in the aggregate, by more than 50 percentage points over a 3 year testing period, or beginning the day after the most recent ownership change, if shorter. The annual limitation may result in the expiration of net operating losses and credits before utilization. As a result of the Merger, the Company recorded deferred tax assets of $10.3 million relating to net operating loss carryforwards which were fully offset by a valuation allowance. The $10.3 million net deferred tax assets recorded in relation to the Merger did not include federal and state net operating loss carryforwards that were estimated to expire under Internal Revenue Code Sections 382 as a result of the Merger. The Company has not yet evaluated the impact of Section 382 and Section 383 on its remaining tax attributes that were generated by Ocuphire since the formation of the Company in 2018. The Company recognizes interest and/or penalties related to uncertain tax positions in income tax expense. There were no uncertain tax positions as of December 31, 2021 and 2020, and as such, no interest or penalties were recorded to income tax expense. The Company’s corporate returns are subject to examination for the beginning with the 2018 tax year for both federal income tax purposes and for state income tax purposes in one state jurisdiction. |
Subsequent Events
Subsequent Events | 12 Months Ended |
Dec. 31, 2021 | |
Subsequent Events [Abstract] | |
Subsequent Events | 13. Subsequent Events 2020 Plan Evergreen Provision Under the 2020 Plan, the shares reserved automatically increase on January 1 of each year, for a period of not more than ten years from the date the 2020 Plan is approved by the stockholders of the Company, commencing on January 1, 2021 and ending on (and including) January 1, 2030, by an amount equal to 5% of the shares of common stock outstanding as of December 31st of the preceding calendar year. Notwithstanding the foregoing, the Board of Directors may act prior to January 1st of a given year to provide that there will be no January 1 increase in the share reserve for such year or that the increase in the share reserve for such year will be a lesser number of shares of common stock than would otherwise occur pursuant to the preceding sentence. On January 1, 2022, 942,291 shares were added to the 2020 Plan as a result of the evergreen provision. |
Company Description and Summa_2
Company Description and Summary of Significant Accounting Policies (Policies) | 12 Months Ended |
Dec. 31, 2021 | |
Company Description and Summary of Significant Accounting Policies [Abstract] | |
Nature of Business | Nature of Business Ocuphire is a clinical-stage ophthalmic biopharmaceutical company focused on developing and commercializing therapies for the treatment of refractive and retinal Ocuphire . The Company has also in-licensed second-generation product candidates and analogs of APX3330. The Company has sustained operating losses since inception and expects such losses to continue indefinitely until a sustained revenue source is realized. Management plans to continue financing the Company’s operations primarily through additional issuances of the Company’s equity and debt securities. If adequate funds are not available, the Company may be required to delay, reduce the scope of, or eliminate part or all of its research and development programs. |
Reverse Merger with Rexahn | Reverse Merger with Rexahn On June 17, 2020, Ocuphire, Rexahn Pharmaceuticals, Inc. (“Rexahn”), Razor Merger Sub, Inc., a Delaware corporation and wholly-owned subsidiary of Rexahn (“Merger Sub”), entered into an Agreement and Plan of Merger and Reorganization, as amended on June 29, 2020 (as amended, the “Merger Agreement”), pursuant to which, among other things, and subject to the satisfaction or waiver of certain conditions set forth in the Merger Agreement, Merger Sub would merge with and into Ocuphire, with Ocuphire continuing as a wholly-owned subsidiary of Rexahn and the surviving corporation of the merger (the “Merger”). The Merger closed on November 5, 2020. Upon completion of the Merger, Rexahn changed its name to Ocuphire Pharma, Inc. and changed its ticker symbol on the Nasdaq Capital Market to “OCUP”. The Company’s headquarters is located in Farmington Hills, Michigan. |
Basis of Presentation | Basis of Presentation The accompanying financial statements have been prepared in accordance with accounting standards generally accepted in the United States of America (“GAAP”). All of the share and per share amounts presented were adjusted, on a retroactive basis, to reflect the exchange of the shares of Ocuphire pre-Merger (“Private Ocuphire”) into 1.0565 shares of the Company (the “Exchange Ratio”), except for par value and share authorizations of Private Ocuphire for periods presented prior to the Merger. On December 31, 2021, the Company merged its wholly owned subsidiary, OcuSub Inc, with and into the Company, with the Company remaining as the surviving entity. The merger of the Company’s wholly owned subsidiary did not have a financial impact to the periods presented. Upon close of this merger, the Company did not have any remaining entities that required consolidation for financial statement reporting purposes. |
Going Concern | Going Concern The Company’s ability to continue operating as a going concern is contingent upon, among other things, its ability to secure additional financing and to achieve and maintain profitable operations. The Company plans to issue additional equity instruments and possibly debt to finance operating and working capital requirements. While the Company expects to obtain the additional financing that is needed, there is no assurance that the Company will be successful in obtaining the necessary funding for future operations. These factors raise substantial doubt as to the Company’s ability to continue as a going concern. The consolidated financial statements do not include any adjustments that might result from the outcome of these uncertainties. |
Common Stock Valuation | Common Stock Valuation Prior to the close of the Merger, due to the absence of an active market for the Private Ocuphire’s common stock, the Company utilized methodologies in accordance with the framework of the American Institute of Certified Public Accountants’ Technical Practice Aid, Valuation of Privately-Held Company Equity Securities Issued as Compensation For the valuation of equity awards granted in October 2020 and September 2020, the Company used a contemporaneous third-party valuation of $8.76 and $7.89 per share, respectively. For the valuation of equity awards granted in April 2020 and June 2020, the Company applied a straight-line calculation using the contemporaneous third-party valuations of $1.74 per share as of March 31, 2020 and $9.54 per share as of June 18, 2020 to determine the fair value of Private Ocuphire common stock. Using the benefit of hindsight, the Company determined that the straight-line calculation would provide the most reasonable conclusion for the valuation of the Company’s common stock on these interim dates between valuations because the Company did not identify any single event or series of events that occurred during this interim period that would have caused a material change in fair value. Based on this calculation, the Company assessed the fair value of its common stock for awards granted in April 2020 and June 2020 at $2.33 and $8.65 per share, respectively. |
Use of Estimates | Use of Estimates The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates. |
Segment Information | Segment Information Operating segments are components of an enterprise for which separate financial information is available and is evaluated regularly by the Company’s chief operating decision maker in deciding how to allocate resources and assessing performance. The Company’s chief operating decision maker is its Chief Executive Officer. The Company’s Chief Executive Officer views the Company’s operations and manages its business in one operating segment, which is the business of development and commercialization of products related to vision performance and health. Accordingly, the Company has a single reporting segment. |
Cash and Cash Equivalents | Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of 90 days or less at the time of deposit to be cash equivalents. |
Concentration of Credit Risk | Concentration of Credit Risk Financial instruments that potentially subject the Company to a concentration of credit risk consist of cash and cash equivalents. The Company’s cash is held by two long-standing financial institutions in the United States. Amounts on deposit may at times exceed federally insured limits. Management believes that the financial institutions are financially sound, and accordingly, minimal credit risk exists with respect to the financial institutions. As of December 31, 2021, the Company had deposits that exceeded federally insured amounts by approximately $24.0 million. |
Short-term Investments | Short-term Investments The Company determines the appropriate classification of its investments in debt and equity securities at the time of purchase and are recorded on a settlement date basis. The Company’s investments are comprised of equity securities, which in accordance with the fair value hierarchy described below are recorded at fair value using Level l inputs on the consolidated balance sheets. Subsequent changes in fair values are recorded in other (expense) income, net on the consolidated statements of comprehensive loss. The Company classifies investments available to fund current operations as current assets on its consolidated balance sheets. The Company did not recognize any impairments on its investments to date through December 31, 2021. |
Revenue Recognition | Revenue Recognition The Company follows the provisions of Accounting Standards Codification (“ASC”) 606, Revenue from Contracts with Customers . The guidance provides a five-step model to determine how revenue is recognized. The Company has entered into license agreements which have revenue recognition implications. (See Note 10 – Collaboration License Agreements.) In determining the appropriate amount of revenue to be recognized, the Company performs the following steps: (i) identification of the contracts with a customer; (ii) determination of the performance obligations in the contract; (iii) measurement of the transaction price, including potential constraints on variable consideration; (iv) allocation of the transaction price to the performance obligations based on estimated stand-alone selling prices; and (v) recognition of revenue when (or as) the Company satisfies a performance obligation. A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account in ASC 606. Performance obligations may include license rights, development services, and services associated with regulatory submission and approval processes. Significant management judgment is required to determine the level of effort required under an arrangement and the period over which the Company expects to complete its performance obligations under the arrangement. If the Company cannot reasonably estimate when its performance obligations are either completed or become inconsequential, then revenue recognition is deferred until the Company can reasonably make such estimates. Revenue is then recognized over the remaining estimated period of performance using the cumulative catch-up method. As part of the accounting for these arrangements, the Company must develop assumptions that require judgment to determine the stand-alone selling price of each performance obligation identified in the contract. The Company uses key assumptions to determine the stand-alone selling price, which may include forecasted revenues, development timelines, reimbursement rates for personnel costs, discount rates and probabilities of technical and regulatory success. The Company allocates the total transaction price to each performance obligation based on the estimated relative standalone selling prices of the promised goods or service underlying each performance obligation. Licenses of intellectual property: If the license to the Company’s intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, the Company recognizes revenues from non-refundable, up-front fees allocated to the license when the license is transferred to the customer, and the customer can use and benefit from the license. For licenses that are bundled with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. Milestone payments: At the inception of each arrangement that includes milestone payments, the Company evaluates whether the milestones are considered probable of being achieved and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the value of the associated milestone (such as a regulatory submission) is included in the transaction price. Milestone payments that are not within the control of the Company, such as approvals from regulators, are not considered probable of being achieved until such contingency occurs (such as receipt of those approvals). When the Company’s assessment of probability of achievement changes and variable consideration becomes probable, any additional estimated consideration is allocated to each performance obligation based on the estimated relative standalone selling prices of the promised goods or service underlying each performance obligation and recorded in collaborations revenue based upon when the customer obtains control of each element. Royalties: For arrangements that include sales-based royalties, including milestone payments based on the level of sales, and the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (a) when the related sales occur, or (b) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). |
General and Administrative Expenses | General and Administrative Expenses General and administrative expenses (“G&A”) consist primarily of personnel-related costs, including salaries and stock-based compensation costs, for personnel in functions not directly associated with research and development activities. Other significant costs include legal fees relating to intellectual property and corporate matters, professional fees for accounting and tax services, settlement costs with third parties and other services provided by business consultants. |
Research and Development | Research and Development Research and development expenses (“R&D”) consist of costs incurred in performing research and development activities, including compensation for research and development employees and consultants, costs associated with preclinical studies and clinical trials, regulatory activities, manufacturing activities to support clinical activities, license fees, fees paid to external service providers that conduct certain research and development, and an allocation of R&D related overhead expenses. |
Acquired In-Process Research and Development Expenses | Acquired In‑Process Research and Development Expenses The Company includes costs to acquire or in‑license product candidates as acquired in‑process research and development expenses (“IPR&D”). These costs are immediately expensed provided that the payments do not also represent processes or activities that would constitute a “business” as defined under GAAP or provided that the product candidate has not achieved regulatory approval for marketing, and absent obtaining such approval, has no alternative future use. Royalties owed on future sales of any licensed product will be expensed in the period the related revenues are recognized. See Note 8 – Apexian Sublicense Agreement. |
Other (Expense) Income, net | Other (Expense) Income, net Other (expense) income, net reflected in this line item includes payments made by the Company in connection with the Contingent Value Rights Agreement discussed further below with former Rexahn shareholders. In addition, Other (expense) income, net includes interest earned from cash and cash equivalent investments, realized and unrealized gains (losses) from equity investments and reimbursements in connection with grants and other sources. |
Share-Based Compensation | Share‑Based Compensation The Company accounts for share‑based compensation in accordance with the provisions of the Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC 718”), Compensation — Stock Compensation |
Warrant Liabilities | Warrant Liabilities The Company issued Series A Warrants in connection with the Pre-Merger Financing (see Note 9 – Pre-Merger Financing) and assumed Rexahn warrants issued prior to the Merger. The Company accounts for these warrants as a liability while outstanding at fair value during periods when certain provisions preclude equity accounting treatment for these instruments. Additionally, issuance costs associated with the warrants classified as liabilities are expensed as incurred and reflected as interest expense in the accompanying consolidated statements of comprehensive loss. The change in fair value of the warrant liabilities while outstanding were recognized as a component of the fair value change in derivative and warrant liabilities line item in the consolidated statements of comprehensive loss. |
Premium Conversion Derivatives | Premium Conversion Derivatives The Company evaluates all conversion and redemption features contained in a debt instrument to determine if there are any embedded derivatives that require separation from the host debt instrument. An embedded derivative that requires separation is bifurcated from its host debt instrument and a corresponding discount to the host debt instrument is recorded. The discount is amortized and recorded to interest expense over the term of the host debt instrument using the straight-line method which approximates the effective interest method. The embedded derivative is accounted for separately on a fair market value basis while outstanding. The Company records the fair value changes of a separated embedded derivative at each reporting period in the fair value change in derivative and warrant liabilities line item in the accompanying consolidated statements of comprehensive loss. The Company determined that the redemption features under the convertible notes, while they were outstanding, qualified as embedded derivatives and were separated from their debt hosts. |
Fair Value Measurements | Fair Value Measurements The Company follows accounting guidance that emphasizes that fair value is a market-based measurement, not an entity-specific measurement. Fair value is defined as “the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date.” Fair value measurements are defined on a three-level hierarchy: • Level 1 inputs: Unadjusted quoted prices for identical assets or liabilities in active markets; • Level 2 inputs: Quoted prices for similar assets and liabilities in active markets, quoted prices in markets that are not active, or inputs which are observable, whether directly or indirectly, for substantially the full term of the asset or liability; and • Level 3 inputs: Unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability in which there is little, if any, market activity for the asset or liability at the measurement date. As of December 31, 2021 and 2020, the fair values of cash and cash equivalents, prepaid and other assets, accounts payable, accrued expenses and short-term loan approximated their carrying values because of the short-term nature of these assets or liabilities. The estimated fair value of the Company’s convertible notes while outstanding were based on amortized cost which was deemed to approximate fair value. The fair value of the investments, while outstanding, were based on observable Level 1 inputs in the form of quoted market prices from a major stock exchange. The fair value of the warrant liabilities and premium conversion derivatives, while outstanding, were based on cash flow models discounted at current implied market rates evidenced in recent arms-length transactions representing expected returns by market participants for similar instruments and were based on Level 3 inputs. The fair value of financial instruments measured on a recurring basis is as follows (in thousands): As of December 31, 2021 Description Total Level 1 Level 2 Level 3 Assets: Short-term investments $ 219 $ 219 $ — $ — Total assets at fair value $ 219 $ 219 $ — $ — As of December 31, 2020 Description Total Level 1 Level 2 Level 3 Liabilities: Warrant liabilities $ 27,964 $ — $ — $ 27,964 Total liabilities at fair value $ 27,964 $ — $ — $ 27,964 The following table provides a roll-forward of investments measured at fair value on a recurring basis using observable level 1 inputs for the year ended December 31, 2021 and 2020 (in thousands): 2021 2020 Short-term investments Balance as of beginning of period $ — $ — Receipt of investments related to license agreement 289 — Unrealized loss (70 ) — Balance as of end of period $ 219 $ — The following table provides a roll-forward of the warrant liabilities and premium conversion derivatives measured at fair value on a recurring basis using unobservable level 3 inputs for the years ended December 31, 2021 and 2020 (in thousands): 2021 2020 Warrant liabilities Balance as of beginning of period $ 27,964 $ — Value assigned to warrants upon in connection with pre-merger financing — 25,821 Issuance of warrants to former Rexahn stockholders classified as a liability — 768 Cash settlement of warrant liabilities — (506 ) Change in fair value of warrant liabilities 33,829 1,945 Reclassification of warrants from liability to equity (61,793 ) (64 ) Balance as of end of period $ — $ 27,964 2021 2020 Premium conversion derivatives Balance as of beginning of period $ — $ 2,714 Value assigned to the underlying derivatives in connection with convertible notes — 831 Revaluation due to convertible note extinguishment — (3,086 ) Change in fair value of premium conversion derivatives — (459 ) Balance as of end of period $ — $ — There were no financial instruments measured on a non-recurring basis for any of the periods presented. |
Income Taxes | Income Taxes The Company utilizes the liability method of accounting for income taxes as required by ASC 740, Income Taxes |
Property and Equipment | Property and Equipment Property and equipment, net is recorded at cost and reduced by accumulated depreciation. Depreciation expense is recognized over the estimated useful lives of the assets using the straight-line method. Equipment and furniture are depreciated over a five year estimated useful life. Tangible assets acquired for research and development activities which have alternative use are capitalized and depreciated over the useful life of the acquired asset. Estimated useful lives are periodically reviewed, and when appropriate, changes are made prospectively. When certain events or changes in operating conditions occur, asset lives may be adjusted and an impairment assessment may be performed on the recoverability of the carrying amounts. Maintenance and repairs are charged directly to expense as incurred. |
Recent Accounting Pronouncements | Recent Accounting Pronouncements In June 2016, the FASB issued Accounting Standards Update (“ASU”) 2016-13, “ Financial Instruments – Credit Losses” In August 2020, FASB issued ASU 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity which, among other things, provides guidance on how to account for contracts on an entity’s own equity. This ASU eliminates the beneficial conversion and cash conversion accounting models for convertible instruments. It also amends the accounting for certain contracts in an entity’s own equity that are currently accounted for as derivatives because of specific settlement provisions. In addition, this ASU modifies how particular convertible instruments and certain contracts that may be settled in cash or shares impact the diluted EPS computation. The amendments in this ASU are effective for public business entities that meet the definition of a Securities and Exchange Commission (“SEC”) filer, excluding entities eligible to be smaller reporting companies as defined by the SEC, for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. For all other entities, the amendments are effective for fiscal years beginning after December 15, 2023, including interim periods within those fiscal years. The Company is currently evaluating the impact of ASU 2020-06 on its consolidated financial statements. In November 2021, the FASB issued ASU 2021-10, Government Assistance (Topic 832) - Disclosures by Business Entities about Government Assistance, |
Company Description and Summa_3
Company Description and Summary of Significant Accounting Policies (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Company Description and Summary of Significant Accounting Policies [Abstract] | |
Fair Value of Financial Instruments Measured on a Recurring Basis | The fair value of financial instruments measured on a recurring basis is as follows (in thousands): As of December 31, 2021 Description Total Level 1 Level 2 Level 3 Assets: Short-term investments $ 219 $ 219 $ — $ — Total assets at fair value $ 219 $ 219 $ — $ — As of December 31, 2020 Description Total Level 1 Level 2 Level 3 Liabilities: Warrant liabilities $ 27,964 $ — $ — $ 27,964 Total liabilities at fair value $ 27,964 $ — $ — $ 27,964 |
Fair Value, Investments Measured on a Recurring Basis | The following table provides a roll-forward of investments measured at fair value on a recurring basis using observable level 1 inputs for the year ended December 31, 2021 and 2020 (in thousands): 2021 2020 Short-term investments Balance as of beginning of period $ — $ — Receipt of investments related to license agreement 289 — Unrealized loss (70 ) — Balance as of end of period $ 219 $ — |
Warrant Liabilities and Premium Conversion Derivatives Measured at Fair Value | The following table provides a roll-forward of the warrant liabilities and premium conversion derivatives measured at fair value on a recurring basis using unobservable level 3 inputs for the years ended December 31, 2021 and 2020 (in thousands): 2021 2020 Warrant liabilities Balance as of beginning of period $ 27,964 $ — Value assigned to warrants upon in connection with pre-merger financing — 25,821 Issuance of warrants to former Rexahn stockholders classified as a liability — 768 Cash settlement of warrant liabilities — (506 ) Change in fair value of warrant liabilities 33,829 1,945 Reclassification of warrants from liability to equity (61,793 ) (64 ) Balance as of end of period $ — $ 27,964 2021 2020 Premium conversion derivatives Balance as of beginning of period $ — $ 2,714 Value assigned to the underlying derivatives in connection with convertible notes — 831 Revaluation due to convertible note extinguishment — (3,086 ) Change in fair value of premium conversion derivatives — (459 ) Balance as of end of period $ — $ — |
Merger (Tables)
Merger (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Merger [Abstract] | |
Purchase Price Paid In Merger | The total purchase price paid in the Merger has been allocated to the net assets acquired and liabilities assumed based on their fair values as of the completion of the Merger. The following summarizes the purchase price paid in the Merger (in thousands, except share and per share amounts): Number of shares of the combined organization owned by the Company’s Pre-Merger stockholders 1,120,800 Multiplied by the fair value per share of REXN’s common stock (1) $ 7.24 Fair value of common stock issued to affect the Merger 8,115 Fair value of warrants and options issued to affect the Merger 768 Transaction costs 1,575 Purchase price $ 10,458 (1) Based on the last reported sale price of the Rexahn’s common stock on the Nasdaq Capital Market on November 5, 2020, the closing date of the Merger, and gives effect to the Reverse Stock Split. |
Allocation of Purchase Price | The allocation of the purchase price is as follows: Cash acquired $ 2,014 Net assets assumed 68 IPR&D (2) 8,376 Purchase price $ 10,458 (2) Represents the pre-Merger research and development projects of Rexahn which were in-process, but not yet completed, and which the Company may advance post-Merger. This includes the development of RX-3117, RX-0301 and RX-0047. Current accounting standards require that the fair value of IPR&D projects acquired in an asset acquisition with no alternative future use be allocated a portion of the consideration transferred and charged to expense on the acquisition date. The acquired assets did not have outputs or employees. |
Supplemental Balance Sheet In_2
Supplemental Balance Sheet Information (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Supplemental Balance Sheet Information [Abstract] | |
Prepaid and Other Assets | Prepaid and other assets consist of the following (in thousands): December 31, 2021 2020 Prepaids $ 1,243 $ 1,243 Other 71 26 Total prepaids and other assets $ 1,314 $ 1,269 |
Property and Equipment, Net | Property and equipment held for use by category are presented in the following table (in thousands): December 31, 2021 2020 Equipment $ 20 $ 20 Furniture 5 5 Total property and equipment 25 25 Less accumulated depreciation (15 ) (11 ) Property and equipment, net $ 10 $ 14 |
Accrued Expenses | Accrued expenses consist of the following (in thousands): December 31, 2021 2020 R&D services and supplies $ 1,081 $ 1,440 Payroll 488 320 Professional services 84 186 Other 80 25 Total $ 1,733 $ 1,971 |
Share-based Compensation (Table
Share-based Compensation (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Share-based Compensation [Abstract] | |
Share-Based Compensation Expense | Share-based compensation expense was included in general and administrative and research and development costs as follows in the accompanying statements of comprehensive loss for the periods indicated below (in thousands): December 31, 2021 2020 General and administrative $ 1,116 $ 675 Research and development 798 831 Total share-based compensation $ 1,914 $ 1,506 |
Stock Option Plan Activity | The following table summarizes the Company’s stock option plan activity: Number of Options Weighted Average Exercise Price Weighted Average Remaining Contractual Term (years) Aggregate Intrinsic Value(1) (in thousands) Outstanding at December 31, 2019 1,037,705 $ 1.06 9.20 $ 1,374 Granted 830,167 $ 3.50 — — Exercised (40,672 ) $ — — — Forfeited/Cancelled (43,002 ) $ — — — Outstanding at December 31, 2020 1,784,198 $ 2.17 8.87 $ 7,744 Granted 420,300 $ 5.72 — — Exercised (73,442 ) $ — — — Forfeited/Cancelled (34,220 ) $ — — — Outstanding at December 31, 2021 2,096,836 $ 2.97 8.20 $ 2,795 Vested and exercisable at December 31, 2021 1,281,263 $ 1.88 7.63 $ 2,370 (1) The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying options and the fair value of our common stock as of December 31, 2021 and 2020 of $3.73 and $6.49 per share (as adjusted for the Exchange Ratio), respectively. |
Weighted Average Assumptions Used in Black-Scholes Option-pricing Model | The weighted‑average assumptions used in the Black‑Scholes option‑pricing model are as follows during the years ended December 31, 2021 and 2020: 2021 2020 Expected stock price volatility 98.1 % 86.8 % Expected life of options (years) 5.8 7.2 Expected dividend yield 0 % 0 % Risk free interest rate 0.9 % 0.6 % |
Restricted Stock Awards Activity | A summary of RSA activity is as follows for the years ended December 31, 2021 and 2020: Number of Shares Non-vested at December 31, 2019 — Granted 40,000 Vested — Non-vested at December 31, 2020 40,000 Granted — Vested (40,000 ) Non-vested at December 31, 2021 — |
Net loss per share (Tables)
Net loss per share (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Net loss per share [Abstract] | |
Anti-dilutive Securities Excluded from Computation of Net Loss per Share | The following potential common shares were not considered in the computation of diluted net loss per share as their effect would have been anti-dilutive for the year end periods presented below: 2021 2020 Series A, Series B and RDO warrants 7,282,999 6,331,674 Stock options 2,096,836 1,784,198 Restricted stock awards including pending issuances of stock for services 6,970 40,000 Former Rexahn warrants 66,538 66,538 Former Rexahn options 82 123 |
Income Taxes (Tables)
Income Taxes (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Income Taxes [Abstract] | |
Reconciliation of Statutory to Effective Income Tax Rate | A reconciliation of income tax computed at the statutory federal income tax rate to the provision (benefit) for income taxes included in the accompanying statements of comprehensive loss is as follows for the years ended December 31, 2021 and 2020: 2021 2020 Income tax (benefit) provision at federal statutory rate (21.0 )% (21.0 )% Valuation allowance 11.9 13.8 State income tax, net of federal benefit (4.8 ) (4.7 ) Acquired in-process research and development expense — 8.8 Warrants 15.3 7.6 Convertible notes — (3.3 ) Stock options (0.1 ) (0.1 ) Research and development (1.1 ) (1.1 ) Other (0.2 ) — Effective tax rate — % — % |
Deferred Tax Assets and Liabilities | Significant components of the Company’s deferred tax assets and liabilities are summarized in the tables below as of December 31, 2021 and 2020: 2021 2020 Deferred tax assets: Federal and state operating loss carryforwards $ 19,244 $ 3,351 Acquired intangibles 547 547 Organizational costs 7 8 Other 18 — Share-based compensation 811 466 Research and development 1,035 275 Subtotal 21,662 4,647 Valuation allowance (21,662 ) (4,647 ) Total deferred tax assets, net of valuation allowance — — Deferred tax liabilities: Total deferred tax liabilities — — Net deferred tax assets $ — $ — |
Company Description and Summa_4
Company Description and Summary of Significant Accounting Policies, Nature of Business (Details) | 12 Months Ended |
Dec. 31, 2021Product | |
Nature of Business [Abstract] | |
Number of small molecule product candidates | 2 |
Company Description and Summa_5
Company Description and Summary of Significant Accounting Policies, Basis of Presentation (Details) | Nov. 05, 2020 | Dec. 31, 2021 |
Basis of Presentation [Abstract] | ||
Exchange ratio | 1.0565 | 1.0565 |
Company Description and Summa_6
Company Description and Summary of Significant Accounting Policies, Common Stock Valuation (Details) - $ / shares | 1 Months Ended | |||||
Oct. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Apr. 30, 2020 | Jun. 18, 2020 | Mar. 31, 2020 | |
Common Stock Valuation [Abstract] | ||||||
Equity awards granted, third-party valuation (in dollars per share) | $ 8.76 | $ 7.89 | ||||
Equity awards granted, straight-line using third-party valuation (in dollars per share) | $ 9.54 | $ 1.74 | ||||
Fair value of common stock for awards granted (in dollars per share) | $ 8.65 | $ 2.33 |
Company Description and Summa_7
Company Description and Summary of Significant Accounting Policies, Segment Information (Details) | 12 Months Ended |
Dec. 31, 2021Segment | |
Segment Information [Abstract] | |
Number of operating segments | 1 |
Company Description and Summa_8
Company Description and Summary of Significant Accounting Policies, Concentration of Credit Risk (Details) $ in Millions | Dec. 31, 2021USD ($) |
Concentration of Credit Risk [Abstract] | |
Deposits that exceeded federally insured amounts | $ 24 |
Company Description and Summa_9
Company Description and Summary of Significant Accounting Policies, Investments (Details) $ in Thousands | 12 Months Ended |
Dec. 31, 2021USD ($) | |
Other than Temporary Impairment Losses, Investments [Abstract] | |
Impairments on investments | $ 0 |
Company Description and Summ_10
Company Description and Summary of Significant Accounting Policies, Fair Value of Financial Instruments Measured on a Recurring Basis (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Company Description and Summary of Significant Accounting Policies [Abstract] | ||
Transfers from Level 1 to Level 2 | $ 0 | $ 0 |
Transfers from Level 2 to Level 1 | 0 | 0 |
Transfers in into Level 3 | 0 | 0 |
Transfers out of Level 3 | 0 | 0 |
Recurring Basis [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 219 | |
Liabilities [Abstract] | ||
Liabilities at fair value | 27,964 | |
Recurring Basis [Member] | Warrant Liabilities [Member] | ||
Liabilities [Abstract] | ||
Liabilities at fair value | 27,964 | |
Recurring Basis [Member] | Short- term investments [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 219 | |
Recurring Basis [Member] | Level 1 [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 219 | |
Liabilities [Abstract] | ||
Liabilities at fair value | 0 | |
Recurring Basis [Member] | Level 1 [Member] | Warrant Liabilities [Member] | ||
Liabilities [Abstract] | ||
Liabilities at fair value | 0 | |
Recurring Basis [Member] | Level 1 [Member] | Short- term investments [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 219 | |
Recurring Basis [Member] | Level 2 [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 0 | |
Liabilities [Abstract] | ||
Liabilities at fair value | 0 | |
Recurring Basis [Member] | Level 2 [Member] | Warrant Liabilities [Member] | ||
Liabilities [Abstract] | ||
Liabilities at fair value | 0 | |
Recurring Basis [Member] | Level 2 [Member] | Short- term investments [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 0 | |
Recurring Basis [Member] | Level 3 [Member] | ||
Assets [Abstract] | ||
Assets at fair value | 0 | |
Liabilities [Abstract] | ||
Liabilities at fair value | 27,964 | |
Recurring Basis [Member] | Level 3 [Member] | Warrant Liabilities [Member] | ||
Liabilities [Abstract] | ||
Liabilities at fair value | $ 27,964 | |
Recurring Basis [Member] | Level 3 [Member] | Short- term investments [Member] | ||
Assets [Abstract] | ||
Assets at fair value | $ 0 |
Company Description and Summ_11
Company Description and Summary of Significant Accounting Policies, Equity Investments Measured at Fair Value (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Equity Investments [Abstract] | ||
Unrealized loss | $ (70) | $ 0 |
Recurring Basis [Member] | Level 1 [Member] | Investments [Member] | ||
Equity Investments [Abstract] | ||
Balance as of beginning of period | 0 | 0 |
Receipt of investments related to license agreement | 289 | 0 |
Unrealized loss | (70) | 0 |
Balance as of end of period | $ 219 | $ 0 |
Company Description and Summ_12
Company Description and Summary of Significant Accounting Policies, Warrant Liabilities and Premium Conversion Derivatives Measured at Fair Value (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] | ||
Reclassification of warrants from liability to equity | $ 61,793 | |
Level 3 [Member] | Warrant Liabilities [Member] | ||
Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] | ||
Balance as of beginning of period | 27,964 | $ 0 |
Value assigned to warrants upon in connection with pre-merger financing | 0 | 25,821 |
Issuance of warrants to former Rexahn stockholders classified as a liability | 0 | 768 |
Cash settlement of warrant liabilities | 0 | (506) |
Change in fair value of warrant liabilities | 33,829 | 1,945 |
Reclassification of warrants from liability to equity | (61,793) | (64) |
Balance as of end of period | 0 | 27,964 |
Level 3 [Member] | Premium Conversion Derivatives [Member] | ||
Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] | ||
Balance as of beginning of period | 0 | 2,714 |
Value assigned to the underlying derivatives in connection with convertible notes | 0 | 831 |
Revaluation due to convertible note extinguishment | 0 | (3,086) |
Change in fair value of premium conversion derivatives | 0 | (459) |
Balance as of end of period | 0 | 0 |
Nonrecurring Basis [Member] | ||
Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] | ||
Financial instruments liabilities at fair value | $ 0 | $ 0 |
Company Description and Summ_13
Company Description and Summary of Significant Accounting Policies, Property and Equipment (Details) | 12 Months Ended |
Dec. 31, 2021 | |
Equipment [Member] | |
Property and Equipment [Abstract] | |
Estimated useful life | 5 years |
Furniture [Member] | |
Property and Equipment [Abstract] | |
Estimated useful life | 5 years |
Merger (Details)
Merger (Details) | Nov. 05, 2020Director$ / sharesshares | Dec. 31, 2021$ / sharesshares | Dec. 31, 2020$ / sharesshares | Nov. 19, 2020shares | Jun. 29, 2020shares |
Merger Information [Abstract] | |||||
Common stock issued (in shares) | 7,091,878 | ||||
Common stock, par value (in dollars per share) | $ / shares | $ 0.0001 | $ 0.0001 | $ 0.0001 | ||
Common stock issued (in shares) | 18,845,828 | 10,882,495 | |||
Exchange ratio | 1.0565 | 1.0565 | |||
Number of directors required to complete transaction | Director | 1 | ||||
Securities Purchase Agreement [Member] | |||||
Merger Information [Abstract] | |||||
Common stock issued (in shares) | 3,749,992 | 3,749,992 | 1,249,996 | ||
Former stockholders and Option Holders of Private Ocuphire [Member] | |||||
Merger Information [Abstract] | |||||
Percentage ownership | 86.60% | ||||
Rexahn [Member] | |||||
Merger Information [Abstract] | |||||
Percentage ownership | 13.40% |
Merger, Purchase Price Paid In
Merger, Purchase Price Paid In Merger (Details) - USD ($) $ / shares in Units, $ in Thousands | Nov. 05, 2020 | Dec. 31, 2020 | |
Purchase Price Paid [Abstract] | |||
Fair value of common stock issued to affect the Merger | $ 8,115 | ||
Rexahn [Member] | |||
Purchase Price Paid [Abstract] | |||
Number of shares of the combined organization owned by the Company's Pre-Merger stockholders (in shares) | 1,120,800 | ||
Multiplied by the fair value per share of REXN's common stock (in dollars per share) | [1] | $ 7.24 | |
Fair value of common stock issued to affect the Merger | $ 8,115 | ||
Fair value of warrants and options issued to affect the Merger | 768 | ||
Transaction costs | 1,575 | ||
Purchase price | $ 10,458 | ||
[1] | Based on the last reported sale price of the Rexahn’s common stock on the Nasdaq Capital Market on November 5, 2020, the closing date of the Merger, and gives effect to the Reverse Stock Split. |
Merger, Allocation of Purchase
Merger, Allocation of Purchase Price (Details) - USD ($) $ in Thousands | Nov. 05, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | |
Allocation of Purchase Price [Abstract] | ||||
Cash acquired | $ 0 | $ 2,014 | ||
IPR&D | $ 0 | $ 10,502 | ||
Rexahn [Member] | ||||
Allocation of Purchase Price [Abstract] | ||||
Cash acquired | $ 2,014 | |||
Net assets assumed | 68 | |||
IPR&D | [1] | 8,376 | ||
Purchase price | $ 10,458 | |||
[1] | Represents the pre-Merger research and development projects of Rexahn which were in-process, but not yet completed, and which the Company may advance post-Merger. This includes the development of RX-3117, RX-0301 and RX-0047. Current accounting standards require that the fair value of IPR&D projects acquired in an asset acquisition with no alternative future use be allocated a portion of the consideration transferred and charged to expense on the acquisition date. The acquired assets did not have outputs or employees. |
Merger, Contingent Value Rights
Merger, Contingent Value Rights Agreement (Details) | 12 Months Ended | |
Dec. 31, 2021USD ($)Milestone | Nov. 05, 2020RightMilestone | |
Contingent Value Rights Agreement [Abstract] | ||
Contingent value rights payment period | 15 years | |
Sum of cash consideration paid by a third party | 75.00% | |
Parent IP deal period | 10 years | |
Payments due under CVR Agreement | $ | $ 91,000 | |
Number of milestones accrued | 0 | 0 |
Number of potential milestones | 0 | 0 |
Rexahn [Member] | ||
Contingent Value Rights Agreement [Abstract] | ||
Number of contingent value right received per common stock | Right | 1 | |
Rexahn [Member] | BioSense Global LLC [Member] | ||
Contingent Value Rights Agreement [Abstract] | ||
Percentage of payments received by Rexahn or its affiliates | 90.00% | |
Rexahn [Member] | Zhejiang HaiChang Biotechnology Co., Ltd [Member] | ||
Contingent Value Rights Agreement [Abstract] | ||
Percentage of payments received by Rexahn or its affiliates | 90.00% |
Merger, Former Rexahn Warrants
Merger, Former Rexahn Warrants and Stock Options (Details) - Rexahn [Member] - $ / shares | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Nov. 05, 2020 | |
Former Rexahn Warrants and Stock Options [Abstract] | |||
Number of warrants outstanding (in shares) | 66,538 | 231,433 | |
Average remaining contractual life | 1 year 10 months 24 days | ||
Number of shares outstanding (in shares) | 82 | 123 | 993 |
Minimum [Member] | |||
Former Rexahn Warrants and Stock Options [Abstract] | |||
Exercise price (in dollars per share) | $ 38.40 | ||
Maximum [Member] | |||
Former Rexahn Warrants and Stock Options [Abstract] | |||
Exercise price (in dollars per share) | $ 198 |
Commitments and Contingencies (
Commitments and Contingencies (Details) | May 06, 2021USD ($)Investorshares | Nov. 05, 2020shares | Dec. 31, 2021USD ($) | Dec. 31, 2020USD ($)shares |
Facility Lease [Abstract] | ||||
Lease term | 7 months | |||
Monthly base rent | $ 3,000 | |||
Rent expense | 116,000 | $ 54,000 | ||
Expected rent payment for the year end 2022 | 36,000 | |||
Issuance of Settlement Shares [Abstract] | ||||
Common stock issued (in shares) | shares | 7,091,878 | |||
Number of accredited investors | Investor | 3 | |||
Accredited Investor [Member] | General and Administrative Expense [Member] | ||||
Issuance of Settlement Shares [Abstract] | ||||
Fair value share settlement amount | $ 1,614,000 | |||
Common Stock [Member] | ||||
Issuance of Settlement Shares [Abstract] | ||||
Common stock issued (in shares) | shares | 891,422 | |||
Common Stock [Member] | Accredited Investor [Member] | ||||
Issuance of Settlement Shares [Abstract] | ||||
Common stock issued (in shares) | shares | 350,000 | |||
Rexahn [Member] | ||||
Facility Lease [Abstract] | ||||
Monthly base rent | 13,000 | |||
Rent expense | $ 116,000 | $ 54,000 |
Supplemental Balance Sheet In_3
Supplemental Balance Sheet Information, Prepaid and Other Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Prepaid and Other Assets [Abstract] | ||
Prepaids | $ 1,243 | $ 1,243 |
Other | 71 | 26 |
Total prepaids and other assets | $ 1,314 | $ 1,269 |
Supplemental Balance Sheet In_4
Supplemental Balance Sheet Information, Property and Equipment (Details) - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Property and Equipment, net [Abstract] | ||
Total property and equipment | $ 25,000 | $ 25,000 |
Less accumulated depreciation | (15,000) | (11,000) |
Property and equipment, net | 10,000 | 14,000 |
Depreciation expense | 4,000 | 8,000 |
Equipment [Member] | ||
Property and Equipment, net [Abstract] | ||
Total property and equipment | 20,000 | 20,000 |
Furniture [Member] | ||
Property and Equipment, net [Abstract] | ||
Total property and equipment | $ 5,000 | $ 5,000 |
Supplemental Balance Sheet In_5
Supplemental Balance Sheet Information, Accrued Expenses (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Accrued Expenses [Abstract] | ||
R&D services and supplies | $ 1,081 | $ 1,440 |
Payroll | 488 | 320 |
Professional services | 84 | 186 |
Other | 80 | 25 |
Total | $ 1,733 | $ 1,971 |
Supplemental Balance Sheet In_6
Supplemental Balance Sheet Information, Short-Term Loan (Details) | 12 Months Ended | ||
Dec. 31, 2021USD ($)Intallment | Dec. 31, 2020USD ($) | Nov. 30, 2021USD ($) | |
Short-Term Loan [Abstract] | |||
Short term loan | $ 538,000 | $ 0 | $ 600,000 |
Number of installments | Intallment | 6 | ||
Annual interest rate | 5.50% | ||
Interest expense | $ 2,000 | $ 6,847,000 | |
Short-term Loan [Member] | |||
Short-Term Loan [Abstract] | |||
Payment on short term loan | $ 108,000 |
Convertible Notes (Details)
Convertible Notes (Details) | Nov. 04, 2020USD ($)shares | Jun. 08, 2020USD ($) | May 25, 2018USD ($) | Sep. 30, 2020 | Dec. 31, 2021USD ($) | Dec. 31, 2020USD ($) |
Convertible Notes [Abstract] | ||||||
Proceeds from issuance of convertible notes | $ 0 | $ 2,197,000 | ||||
Fair value, convertible note | 1,300,000 | |||||
Additional paid-in-capital | 111,588,000 | 19,207,000 | ||||
Proceeds from sale of capital stock | 28,491,000 | 0 | ||||
Fair value change in derivative and warrant liabilities | 33,829,000 | 1,486,000 | ||||
Amortization of note discounts | 0 | 873,000 | ||||
Convertible Notes [Member] | ||||||
Convertible Notes [Abstract] | ||||||
Proceeds from issuance of convertible notes | $ 8,500,000 | |||||
Shares converted to common stock (in shares) | shares | 977,128 | |||||
Premium conversion derivative | $ 2,700,000 | 0 | 2,700,000 | |||
Gain on note extinguishment | 2,400,000 | |||||
Additional paid-in-capital | $ 300,000 | |||||
Increase in additional paid-in capital | $ 1,000,000 | |||||
Convertible notes discount | 800,000 | |||||
Interest rate percentage | 8.00% | |||||
Interest expense | 500,000 | |||||
Proceeds from sale of capital stock | $ 5,000,000 | |||||
Interest rate in period of default | 12.00% | |||||
Fair value change in derivative and warrant liabilities | (500,000) | |||||
Convertible notes discount third party | 8,000 | |||||
Amortization of note discounts | $ 900,000 | |||||
Convertible Notes [Member] | Conversion Agreement [Member] | ||||||
Convertible Notes [Abstract] | ||||||
Conversion rate | 1.75 | |||||
Conversion price quotient | $ 100,000,000 | |||||
Convertible Notes [Member] | CIC [Member] | ||||||
Convertible Notes [Abstract] | ||||||
Conversion rate | 2 | |||||
Convertible Notes [Member] | Qualified Financing [Member] | ||||||
Convertible Notes [Abstract] | ||||||
Conversion rate | 1.75 | |||||
Proceeds from new equity investments | $ 1,000,000 | |||||
Convertible Notes [Member] | Reverse Merger [Member] | ||||||
Convertible Notes [Abstract] | ||||||
Conversion rate | 1.75 | |||||
Convertible Notes [Member] | IPO [Member] | ||||||
Convertible Notes [Abstract] | ||||||
Conversion rate | 1.75 |
Related Party Transactions (Det
Related Party Transactions (Details) | Nov. 05, 2020shares | Dec. 31, 2021USD ($)OfficerDirectorBoardMembershares |
Apexian Sublicense Agreement [Abstract] | ||
Common stock issued (in shares) | 7,091,878 | |
Waiver Agreements [Abstract] | ||
Number of directors signed waiver agreements | Director | 6 | |
Apexian Sublicense Agreement [Member] | ||
Apexian Sublicense Agreement [Abstract] | ||
Common stock issued (in shares) | 843,751 | |
Apexian Sublicense Agreement [Member] | Common Stock [Member] | ||
Apexian Sublicense Agreement [Abstract] | ||
Common stock issued (in shares) | 843,751 | |
Pre-Merger Financing [Member] | ||
Pre-Merger Financing [Abstract] | ||
Amount invested in pre-merger financing | $ | $ 300,000 | |
Number of converted initial shares received by directors (in shares) | 17,729 | |
Number of converted additional shares (in shares) | 53,189 | |
Pre-Merger Financing [Member] | Private Ocuphire [Member] | ||
Pre-Merger Financing [Abstract] | ||
Number of directors | Director | 5 | |
Pre-Merger Financing [Member] | Rexahn [Member] | ||
Pre-Merger Financing [Abstract] | ||
Number of directors | Director | 1 | |
Pre-Merger Financing [Member] | Series A Warrants [Member] | ||
Pre-Merger Financing [Abstract] | ||
Number of converted additional shares (in shares) | 80,366 | |
Pre-Merger Financing [Member] | Series B Warrants [Member] | ||
Pre-Merger Financing [Abstract] | ||
Number of converted additional shares (in shares) | 9,444 | |
Convertible Notes [Member] | ||
Convertible Notes with Related Parties [Abstract] | ||
Aggregate amount of convertible notes issue to board and officers | $ | $ 700,000 | |
Number of board members | BoardMember | 4 | |
Number of officers | Officer | 2 | |
Number of officers also a board member | BoardMember | 1 |
Share-based Compensation, Share
Share-based Compensation, Share-Based Compensation Expense (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Share-based Compensation Expense [Abstract] | ||
Share based compensation | $ 1,914 | $ 1,506 |
General and Administrative [Member] | ||
Share-based Compensation Expense [Abstract] | ||
Share based compensation | 1,116 | 675 |
Research and Development [Member] | ||
Share-based Compensation Expense [Abstract] | ||
Share based compensation | $ 798 | $ 831 |
Share-based Compensation, Stock
Share-based Compensation, Stock Option Plan Activity (Details) - USD ($) | 12 Months Ended | |||||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Feb. 22, 2021 | Nov. 05, 2020 | ||
Ocuphire Stock Options [Abstract] | ||||||
Share based compensation | $ 1,914,000 | $ 1,506,000 | ||||
Inducement Plan [Member] | ||||||
Ocuphire Stock Options [Abstract] | ||||||
Common stock reserved for issuance (in shares) | 325,258 | |||||
2020 Equity Incentive Plan [Member] | ||||||
Ocuphire Stock Options [Abstract] | ||||||
Common stock reserved for issuance (in shares) | 1,000,000 | |||||
2020 Equity Incentive Plan [Member] | Maximum [Member] | ||||||
Ocuphire Stock Options [Abstract] | ||||||
Common stock reserved for issuance (in shares) | 70,325 | |||||
2018 Equity Incentive Plan [Member] | ||||||
Ocuphire Stock Options [Abstract] | ||||||
Common stock reserved for issuance (in shares) | 0 | 1,175,000 | ||||
Vesting period | 48 months | |||||
Weighted Average Exercise Price [Abstract] | ||||||
Aggregate Intrinsic Value | $ 345,000 | $ 175,000 | ||||
Weighted average fair value per share of options granted (in dollars per share) | $ 3.49 | $ 2.77 | ||||
Ocuphire Stock Options [Member] | 2018 Equity Incentive Plan [Member] | ||||||
Ocuphire Stock Options [Abstract] | ||||||
Share based compensation | $ 1,800,000 | $ 1,400,000 | ||||
Number of Options [Roll Forward] | ||||||
Outstanding, beginning balance (in shares) | 1,784,198 | 1,037,705 | ||||
Granted (in shares) | 420,300 | 830,167 | ||||
Exercised (in shares) | (73,442) | (40,672) | ||||
Forfeited/Cancelled (in shares) | (34,220) | (43,002) | ||||
Outstanding, ending balance (in shares) | 2,096,836 | 1,784,198 | 1,037,705 | |||
Vested and exercisable (in shares) | 1,281,263 | |||||
Weighted Average Exercise Price [Abstract] | ||||||
Outstanding, beginning balance (in dollars per share) | $ 2.17 | $ 1.06 | ||||
Granted (in dollars per share) | 5.72 | 3.50 | ||||
Exercised (in dollars per share) | 0 | 0 | ||||
Forfeited/Cancelled (in dollars per share) | 0 | 0 | ||||
Outstanding, ending balance (in dollars per share) | 2.97 | $ 2.17 | $ 1.06 | |||
Vested and exercisable (in dollars per share) | $ 1.88 | |||||
Weighted Average Remaining Contractual Term (years) | 8 years 2 months 12 days | 8 years 10 months 13 days | 9 years 2 months 12 days | |||
Vested and exercisable | 7 years 7 months 17 days | |||||
Aggregate Intrinsic Value | [1] | $ 2,795,000 | $ 7,744,000 | $ 1,374,000 | ||
Aggregate Intrinsic Value, Vested and exercisable | [1] | $ 2,370,000 | ||||
Aggregate intrinsic value (in dollars per share) | $ 3.73 | $ 6.49 | ||||
Weighted average fair value per share of options granted (in dollars per share) | $ 4.36 | $ 3.92 | ||||
[1] | The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying options and the fair value of our common stock as of December 31, 2021 and 2020 of $3.73 and $6.49 per share (as adjusted for the Exchange Ratio), respectively. |
Share-based Compensation, Weigh
Share-based Compensation, Weighted Average Assumptions Used in Black-Scholes Option-pricing Model (Details) - USD ($) $ / shares in Units, $ in Millions | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
2020 Equity Incentive Plan [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award [Abstract] | ||
Common stock available for future issuance (in shares) | 890,542 | |
2018 Equity Incentive Plan [Member] | ||
Weighted-average Assumptions Used in Black-Scholes Option-pricing Model [Abstract] | ||
Expected stock price volatility | 98.10% | 86.80% |
Expected life of options (years) | 5 years 9 months 18 days | 7 years 2 months 12 days |
Expected dividend yield | 0.00% | 0.00% |
Risk free interest rate | 0.90% | 0.60% |
Share-based Compensation Arrangement by Share-based Payment Award [Abstract] | ||
Stock options vested (in shares) | 468,301 | 379,576 |
Weighted average fair value per share of options vesting (in dollars per share) | $ 3.49 | $ 2.77 |
Stock options forfeited (in shares) | 34,220 | 43,002 |
Unrecognized share-based compensation cost | $ 2.4 | |
Weighted average period to recognized share-based compensation | 1 year 1 month 6 days | |
Inducement Plan [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award [Abstract] | ||
Common stock available for future issuance (in shares) | 890,542 |
Share-based Compensation, Restr
Share-based Compensation, Restricted Stock Awards Activity (Details) - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Ocuphire Restricted Stock Awards [Abstract] | ||
Share based compensation | $ 1,914,000 | $ 1,506,000 |
Ocuphire Restricted Stock Awards [Member] | ||
Ocuphire Restricted Stock Awards [Abstract] | ||
Share based compensation | $ 22,000 | $ 100,000 |
Summary of RSA Activity [Abstract] | ||
Non-vested at beginning (in shares) | 40,000 | 0 |
Granted (in shares) | 0 | 40,000 |
Vested (in shares) | (40,000) | 0 |
Non-vested at ending (in shares) | 0 | 40,000 |
Share-based Compensation, Commo
Share-based Compensation, Common Stock Issued for Services (Details) | 12 Months Ended |
Dec. 31, 2021USD ($)Membershares | |
Common Stock Issued for Services [Abstract] | |
Granted stock for services performed (in shares) | shares | 21,414 |
Number of board members, stock granted for services | Member | 2 |
Share based compensation for services | $ | $ 108,000 |
Share-based Compensation, Forme
Share-based Compensation, Former Rexahn Options (Details) - Rexahn [Member] - $ / shares | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Nov. 05, 2020 | |
Former Options [Abstract] | |||
Number of shares outstanding (in shares) | 82 | 123 | 993 |
Number of options expired (in shares) | 41 | ||
Exercise price (in dollars per share) | $ 182.40 | ||
Average remaining contractual life | 6 months |
Apexian Sublicense Agreement (D
Apexian Sublicense Agreement (Details) - USD ($) $ in Thousands | Nov. 05, 2020 | Dec. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 |
Sublicense Agreement [Abstract] | ||||
Common stock issued (in shares) | 7,091,878 | |||
Program costs | $ 0 | $ 1,769 | ||
Apexian Sublicense Agreement [Member] | ||||
Sublicense Agreement [Abstract] | ||||
Common stock issued (in shares) | 843,751 | |||
Payment for license agreement | $ 2,100 | |||
Program costs | $ 400 | |||
Apexian Sublicense Agreement [Member] | Development and Regulatory Milestones [Member] | Maximum [Member] | ||||
Sublicense Agreement [Abstract] | ||||
Milestone payments | 11,000 | |||
Apexian Sublicense Agreement [Member] | Sales Milestones [Member] | Maximum [Member] | ||||
Sublicense Agreement [Abstract] | ||||
Milestone payments | $ 20,000 | |||
Ref-1 Inhibitor Program [Member] | ||||
Sublicense Agreement [Abstract] | ||||
Program costs | $ 300 |
Stockholders' Equity (Deficit),
Stockholders' Equity (Deficit), At-The-Market Program (Details) - USD ($) $ in Thousands | Mar. 11, 2021 | Feb. 12, 2021 | Nov. 05, 2020 | Dec. 31, 2021 | Dec. 31, 2020 |
At-The-Market Program [Abstract] | |||||
Aggregate offering price | $ 2,126 | ||||
Shares sold (in shares) | 7,091,878 | ||||
Gross proceeds | $ 28,491 | 0 | |||
Issuance expenses | $ 0 | $ 1,769 | |||
2021 Shelf [Member] | Maximum [Member] | |||||
At-The-Market Program [Abstract] | |||||
Aggregate offering price | $ 125,000 | ||||
2021 ATM [Member] | |||||
At-The-Market Program [Abstract] | |||||
Shares sold (in shares) | 2,778,890 | ||||
Gross proceeds | $ 13,500 | ||||
Issuance expenses | $ 400 | ||||
2021 ATM [Member] | Maximum [Member] | |||||
At-The-Market Program [Abstract] | |||||
Aggregate offering price | $ 40,000 |
Stockholders' Equity (Deficit_2
Stockholders' Equity (Deficit), Registered Direct Offering (Details) $ / shares in Units, $ in Thousands | Jun. 08, 2021USD ($)$ / sharesshares | Nov. 05, 2020shares | Dec. 31, 2021USD ($)shares | Dec. 31, 2020USD ($)shares |
Registered Direct Offerings [Abstract] | ||||
Shares sold (in shares) | shares | 7,091,878 | |||
Gross proceeds | $ | $ 28,491 | $ 0 | ||
Issuance expenses | $ | $ 0 | $ 1,769 | ||
Common Stock [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Shares sold (in shares) | shares | 891,422 | |||
Registered Direct Offering [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Gross proceeds | $ | $ 15,000 | |||
Registered Direct Offering [Member] | Warrants [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Offering price (in dollars per share) | $ / shares | $ 0.50 | |||
Exercise price (in dollars per share) | $ / shares | $ 6.09 | |||
Expiration period | 5 years | |||
Fair value of warrants | $ | $ 6,400 | |||
Warrants outstanding (in shares) | shares | 1,538,461 | |||
Minimum percentage of beneficial ownership | 4.99% | |||
Maximum percentage of beneficial ownership limitation | 9.99% | |||
Registered Direct Offering [Member] | Common Stock [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Shares sold (in shares) | shares | 3,076,923 | |||
Warrants issued (in shares) | shares | 1,538,461 | |||
Offering price (in dollars per share) | $ / shares | $ 4.875 | |||
Issuance expenses | $ | $ 1,100 | |||
Registered Direct Offering [Member] | Risk-Free Interest Rate [Member] | Warrants [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Measurement input | 0.008 | |||
Registered Direct Offering [Member] | Expected Volatility [Member] | Warrants [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Measurement input | 0.992 | |||
Registered Direct Offering [Member] | Expected Dividend Yield Rate [Member] | Warrants [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Measurement input | 0 | |||
Registered Direct Offering [Member] | Expected Term [Member] | Warrants [Member] | ||||
Registered Direct Offerings [Abstract] | ||||
Expected life | 5 years |
Stockholder Equity (Deficit), P
Stockholder Equity (Deficit), Pre-Merger Financing (Details) $ / shares in Units, $ in Thousands | Feb. 03, 2021shares | Jun. 29, 2020USD ($)shares | Apr. 30, 2021shares | Dec. 31, 2021USD ($)InterestDirector$ / sharesshares | Dec. 31, 2020USD ($)shares | Nov. 19, 2020$ / sharesshares | Nov. 05, 2020shares |
Pre-Merger Financing [Abstract] | |||||||
Common stock issued (in shares) | shares | 18,845,828 | 10,882,495 | |||||
Fair value change of warrant liability and premium conversion derivatives | $ (33,829) | $ (1,486) | |||||
Issuance costs attributed to pre-merger financing | $ 0 | 1,769 | |||||
Rexahn [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Warrants outstanding (in shares) | shares | 66,538 | 231,433 | |||||
Rexahn [Member] | Minimum [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Exercise price (in dollars per share) | $ / shares | $ 38.40 | ||||||
Securities Purchase Agreement [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Common stock issued (in shares) | shares | 1,249,996 | 3,749,992 | 3,749,992 | ||||
Number of trading days | 10 days | ||||||
Securities Purchase Agreement [Member] | Private Ocuphire [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Number of directors | Director | 5 | ||||||
Securities Purchase Agreement [Member] | Rexahn [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Number of directors | Director | 1 | ||||||
Securities Purchase Agreement [Member] | Investors [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Total investment | $ 21,150 | ||||||
Securities Purchase Agreement [Member] | Directors [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Total investment | $ 300 | ||||||
Series A Warrants [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Exercise price (in dollars per share) | $ / shares | $ 4.4795 | ||||||
Exercisable term | 5 years | ||||||
Warrant issued (in shares) | shares | 5,665,838 | ||||||
Percentage of reset price | 120.00% | ||||||
Fair market value of warrants | 25,800 | ||||||
Fair value of warrants exceeded | 21,150 | ||||||
Pre-merger financing | 4,700 | ||||||
Number of interest | Interest | 1 | ||||||
Fair value change of warrant liability and premium conversion derivatives | $ 2,100 | ||||||
Series A Warrants [Member] | Offset to Additional Capital [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Issuance costs attributed to pre-merger financing | $ 1,100 | ||||||
Series A Warrants [Member] | Interest Expense [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Issuance costs attributed to pre-merger financing | $ 700 | ||||||
Series A Warrants [Member] | Risk-Free Interest Rate [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Percentage of measurement input | 0.004 | 0.004 | |||||
Series A Warrants [Member] | Expected Volatility [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Percentage of measurement input | 0.866 | 0.836 | |||||
Series A Warrants [Member] | Expected Term [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Expected life | 4 years 9 months 18 days | 5 years | |||||
Series A Warrants [Member] | Expected Dividend Yield Rate [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Percentage of measurement input | 0 | 0 | |||||
Series A Warrants [Member] | Waiver Agreements [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Fair value change of warrant liability and premium conversion derivatives | $ 33,800 | ||||||
Series B Warrants [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Exercise price (in dollars per share) | $ / shares | $ 0.0001 | ||||||
Number of shares issued, warrants exercised (in shares) | shares | 1,629,634 | ||||||
Warrants outstanding (in shares) | shares | 78,700 | ||||||
Warrant issued (in shares) | shares | 1,708,334 | 665,836 | |||||
Remaining issuable shares (in shares) | shares | 0 | ||||||
Number of trading days including reset date | 45 days | ||||||
Period of issuance date | 6 months | ||||||
Period of after issuance date | 1 year | ||||||
Pre-money valuation amount | $ 10,000 | ||||||
Series B Warrants [Member] | Minimum [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Number of trading days | 9 days | ||||||
Series B Warrants [Member] | Waiver Agreements [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Aggregate number of shares (in shares) | shares | 1,708,334 | ||||||
the Warrants [Member] | |||||||
Pre-Merger Financing [Abstract] | |||||||
Issuance costs attributed to pre-merger financing | $ 1,800 | ||||||
Placement agent cash fee | 1,600 | ||||||
Legal and other fees | $ 200 |
Collaboration and License Agr_2
Collaboration and License Agreements (Details) | Mar. 10, 2020USD ($) | Jul. 31, 2021USD ($)shares | Dec. 31, 2021USD ($)CountryMilestone |
BioSense License and Assignments Agreement [Member] | |||
Collaboration and License Agreement [Abstract] | |||
Upfront payment received | $ 1,650,000 | ||
Milestone payment achieved for performance obligation, recorded as collaboration revenue | $ 100,000 | ||
Milestone payments received | 0 | ||
Maximum amount of payments receivable for development, regulatory and commercial milestones | 84,500,000 | ||
BioSense License and Assignments Agreement [Member] | Rexahn [Member] | |||
Collaboration and License Agreement [Abstract] | |||
Upfront payment received | $ 1,550,000 | ||
Processa License Agreement [Member] | |||
Collaboration and License Agreement [Abstract] | |||
Upfront payment received | $ 200,000 | ||
Milestone payments received | $ 0 | ||
Upfront payment received in common shares (in shares) | shares | 44,689 | ||
Upfront payment received in common shares | $ 289,000 | ||
Period of restriction from selling common stock | 1 year | ||
Number of times sales milestone payments | Milestone | 1 | ||
Percentage of milestone payments eligible to receive on sub-license agreement | 32.00% | ||
Number of countries | Country | 1 | ||
Milestone period to administer drug clinical trial of licensed product on first patient | 3 years | ||
Milestone period to administer drug clinical trial of licensed product on first patient for second indication | 5 years | ||
Period of opportunity to cure breach of agreement | 120 days | ||
Period of prior written notice to be served for termination of agreements | 120 days |
Net loss per share, Anti-diluti
Net loss per share, Anti-dilutive Securities Excluded from Computation of Net Loss per Share (Details) - shares | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Series A, Series B and RDO Warrants [Member] | ||
Net Loss Per Share [Abstract] | ||
Antidilutive securities excluded from computation of net loss per share (in shares) | 7,282,999 | 6,331,674 |
Stock Options [Member] | ||
Net Loss Per Share [Abstract] | ||
Antidilutive securities excluded from computation of net loss per share (in shares) | 2,096,836 | 1,784,198 |
Restricted Stock Awards Including Pending Issuances of Stock for Services [Member] | ||
Net Loss Per Share [Abstract] | ||
Antidilutive securities excluded from computation of net loss per share (in shares) | 6,970 | 40,000 |
Former Rexahn Warrants [Member] | ||
Net Loss Per Share [Abstract] | ||
Antidilutive securities excluded from computation of net loss per share (in shares) | 66,538 | 66,538 |
Former Rexahn Options [Member] | ||
Net Loss Per Share [Abstract] | ||
Antidilutive securities excluded from computation of net loss per share (in shares) | 82 | 123 |
Income Taxes, Reconciliation of
Income Taxes, Reconciliation of Statutory to Effective Income Tax Rate (Details) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Effective Federal Income Tax Rate Reconciliation [Abstract] | ||
Income tax (benefit) provision at federal statutory rate | (21.00%) | (21.00%) |
Valuation allowance | 11.90% | 13.80% |
State income tax, net of federal benefit | (4.80%) | (4.70%) |
Acquired in-process research and development expense | 0.00% | 8.80% |
Warrants | 15.30% | 7.60% |
Convertible notes | 0.00% | (3.30%) |
Stock options | (0.10%) | (0.10%) |
Research and development | (1.10%) | (1.10%) |
Other | (0.20%) | 0.00% |
Effective tax rate | 0.00% | 0.00% |
Income Taxes, Deferred Tax Asse
Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Deferred Tax Assets [Abstract] | ||
Federal and state operating loss carryforwards | $ 19,244 | $ 3,351 |
Acquired intangibles | 547 | 547 |
Organizational costs | 7 | 8 |
Other | 18 | 0 |
Share-based compensation | 811 | 466 |
Research and development | 1,035 | 275 |
Subtotal | 21,662 | 4,647 |
Valuation allowance | (21,662) | (4,647) |
Total deferred tax assets, net of valuation allowance | 0 | 0 |
Deferred Tax Liabilities [Abstract] | ||
Total deferred tax liabilities | 0 | 0 |
Net deferred tax assets | $ 0 | $ 0 |
Income Taxes, Operating Loss Ca
Income Taxes, Operating Loss Carryforwards (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Deferred Tax Assets, Operating Loss Carryforwards, Components [Abstract] | ||
Federal net operating loss carryforward | $ 15,700 | $ 2,700 |
Federal research credit carryforwards | 1,000 | 300 |
State net operating loss carryforward | 3,600 | 600 |
State research credit carryforwards | 0 | 0 |
Income Tax Uncertainties [Abstract] | ||
Uncertain tax positions | 0 | 0 |
Interest and penalty on income tax expense | 0 | 0 |
Deferred tax assets relating to net operating loss carryforwards [Abstract] | ||
Deferred tax assets relating to net operating loss carryforwards | 19,244 | $ 3,351 |
Rexahn stockholders [Member] | ||
Deferred tax assets relating to net operating loss carryforwards [Abstract] | ||
Deferred tax assets relating to net operating loss carryforwards | $ 10,300 |
Subsequent Events (Details)
Subsequent Events (Details) - 2020 Plan Evergreen Provision [Member] - shares | Jan. 01, 2022 | Dec. 31, 2021 |
Subsequent Events [Abstract] | ||
Percentage of common stock shares outstanding | 5.00% | |
Maximum [Member] | ||
Subsequent Events [Abstract] | ||
Period of shares reserved under plan | 10 years | |
Subsequent Event [Member] | ||
Subsequent Events [Abstract] | ||
Number of shares added (in shares) | 942,291 |