Jazz Pharmaceuticals (JAZZ) 8-K12B Notification of registration of securities

Exhibit 16.1

January 18, 2012

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Ladies and Gentlemen:

We have read Item 4.01 of Form 8-K dated January 18, 2012, of Jazz Pharmaceuticals plc (formerly known as Jazz Pharmaceuticals, Inc.) and are in agreement with the statements contained in the third paragraph on page 4 therein. We have no basis to agree or disagree with other statements of the registrant contained therein.

/s/ Ernst & Young LLP