| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Abeona Therapeutics Inc. | COM | 00289Y107 | 2,911 | 1,288,235 | SH | | SOLE | | 1,288,235 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 1,470,357 | 40,854,586 | SH | | SOLE | | 40,854,586 | 0 | 0 |
| Acceleron Pharma Inc. | COM | 00434H108 | 3,315 | 83,900 | SH | | SOLE | | 83,900 | 0 | 0 |
| Achillion Pharmaceuticals, Inc. | COM | 00448Q201 | 3,943 | 1,095,359 | SH | | SOLE | | 1,095,359 | 0 | 0 |
| Acorda Therapeutics, Inc. | COM | 00484M106 | 6,408 | 2,232,589 | SH | | SOLE | | 2,232,589 | 0 | 0 |
| Adamas Pharmaceuticals, Inc. | COM | 00548A106 | 883 | 172,630 | SH | | SOLE | | 172,630 | 0 | 0 |
| Adaptive Biotechnologies Corporation | COM | 00650F109 | 36,011 | 1,165,411 | SH | | SOLE | | 1,165,411 | 0 | 0 |
| Aeglea BioTherapeutics, Inc. | COM | 00773J103 | 13,178 | 1,713,604 | SH | | SOLE | | 1,713,604 | 0 | 0 |
| Affimed N.V. | COM | N01045108 | 588 | 200,000 | SH | | SOLE | | 200,000 | 0 | 0 |
| Aimmune Therapeutics, Inc. | COM | 00900T107 | 14,112 | 673,908 | SH | | SOLE | | 673,908 | 0 | 0 |
| Albireo Pharma, Inc. | COM | 01345P106 | 5,000 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 808,795 | 8,258,068 | SH | | SOLE | | 8,258,068 | 0 | 0 |
| Alkermes plc | SHS | G01767105 | 12,194 | 625,030 | SH | | SOLE | | 625,030 | 0 | 0 |
| Allakos Inc. | COM | 01671P100 | 26,710 | 339,690 | SH | | SOLE | | 339,690 | 0 | 0 |
| Amarin Corporation plc | SPONSORED ADR | 023111206 | 629,811 | 41,544,288 | SH | | SOLE | | 41,544,288 | 0 | 0 |
| AnaptysBio, Inc. | COM | 032724106 | 3,957 | 113,086 | SH | | SOLE | | 113,086 | 0 | 0 |
| Apellis Pharmaceuticals, Inc. | COM | 03753U106 | 7,558 | 313,725 | SH | | SOLE | | 313,725 | 0 | 0 |
| Aquestive Therapeutics, Inc. | COM | 03843E104 | 317 | 99,600 | SH | | SOLE | | 99,600 | 0 | 0 |
| Neoleukin Therapeutics, Inc. | COM | 64049K104 | 32,221 | 11,305,679 | SH | | SOLE | | 11,305,679 | 0 | 0 |
| Aravive, Inc. | COM | 03890D108 | 4,981 | 664,088 | SH | | SOLE | | 664,088 | 0 | 0 |
| Arcus Biosciences, Inc. | COM | 03969F109 | 1,106 | 121,534 | SH | | SOLE | | 121,534 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 | 116,189 | 1,019,557 | SH | | SOLE | | 1,019,557 | 0 | 0 |
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 326,551 | 3,390,270 | SH | | SOLE | | 3,390,270 | 0 | 0 |
| Assembly Biosciences, Inc. | COM | 045396108 | 7,896 | 803,246 | SH | | SOLE | | 803,246 | 0 | 0 |
| Atreca, Inc. | CL A Common | 04965G109 | 43,241 | 3,532,760 | SH | | SOLE | | 3,532,760 | 0 | 0 |
| Audentes Therapeutics, Inc. | COM | 05070R104 | 42,316 | 1,506,438 | SH | | SOLE | | 1,506,438 | 0 | 0 |
| Autolus Therapeutics plc | SPON ADS | 05280R100 | 1,947 | 156,773 | SH | | SOLE | | 156,773 | 0 | 0 |
| Axsome Therapeutics, Inc. | COM | 05464T104 | 15,631 | 772,286 | SH | | SOLE | | 772,286 | 0 | 0 |
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 1,442,246 | 11,777,285 | SH | | SOLE | | 11,777,285 | 0 | 0 |
| Bellicum Pharmaceuticals, Inc. | COM | 079481107 | 2,812 | 2,677,818 | SH | | SOLE | | 2,677,818 | 0 | 0 |
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 36,458 | 12,725,472 | SH | | SOLE | | 12,725,472 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | COM | 09061G101 | 511,518 | 7,589,294 | SH | | SOLE | | 7,589,294 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | NOTE 0.599% 8/1/2024 | 09061GAH4 | 14,722 | 15,000,000 | PRN | | SOLE | | 15,000,000 | 0 | 0 |
| bluebird bio, Inc. | COM | 09609G100 | 3,673 | 40,000 | SH | | SOLE | | 40,000 | 0 | 0 |
| Catalyst Pharmaceuticals, Inc. | COM | 14888U101 | 7,125 | 1,341,902 | SH | | SOLE | | 1,341,902 | 0 | 0 |
| Cerus Corporation | COM | 157085101 | 55,416 | 10,749,937 | SH | | SOLE | | 10,749,937 | 0 | 0 |
| ChemoCentryx, Inc. | COM | 16383L106 | 1,404 | 207,029 | SH | | SOLE | | 207,029 | 0 | 0 |
| Constellation Pharmaceuticals, Inc. | COM | 210373106 | 861 | 133,333 | SH | | SOLE | | 133,333 | 0 | 0 |
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 2,632 | 175,000 | SH | | SOLE | | 175,000 | 0 | 0 |
| Cyclerion Therapeutics, Inc. | COM | 23255M105 | 2,455 | 202,581 | SH | | SOLE | | 202,581 | 0 | 0 |
| CymaBay Therapeutics, Inc. | COM | 23257D103 | 29,222 | 5,707,411 | SH | | SOLE | | 5,707,411 | 0 | 0 |
| CytomX Therapeutics, Inc. | COM | 23284F105 | 1,435 | 194,377 | SH | | SOLE | | 194,377 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 47,382 | 5,509,560 | SH | | SOLE | | 5,509,560 | 0 | 0 |
| Dermira, Inc. | COM | 24983L104 | 5,795 | 906,943 | SH | | SOLE | | 906,943 | 0 | 0 |
| Dova Pharmaceuticals, Inc. | COM | 25985T102 | 2,857 | 102,205 | SH | | SOLE | | 102,205 | 0 | 0 |
| Dynavax Technologies Corporation | COM | 268158201 | 268 | 75,000 | SH | | SOLE | | 75,000 | 0 | 0 |
| Evofem Biosciences, Inc. | COM | 30048L104 | 514 | 102,048 | SH | | SOLE | | 102,048 | 0 | 0 |
| Foamix Pharmaceuticals Ltd. | SHS | M46135105 | 1,514 | 498,189 | SH | | SOLE | | 498,189 | 0 | 0 |
| Forty Seven, Inc. | COM | 34983P104 | 1,605 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Fulgent Genetics, Inc. | COM | 359664109 | 1,299 | 125,000 | SH | | SOLE | | 125,000 | 0 | 0 |
| G1 Therapeutics, Inc. | COM | 3621LQ109 | 2,898 | 127,236 | SH | | SOLE | | 127,236 | 0 | 0 |
| Galapagos NV | SPONSORED ADR | 36315X101 | 3,827 | 25,072 | SH | | SOLE | | 25,072 | 0 | 0 |
| Galmed Pharmaceuticals Ltd. | SHS | M47238106 | 1,031 | 215,594 | SH | | SOLE | | 215,594 | 0 | 0 |
| Genomic Health, Inc. | COM | 37244C101 | 626,973 | 9,244,665 | SH | | SOLE | | 9,244,665 | 0 | 0 |
| GW Pharmaceuticals plc | ADS | 36197T103 | 42,658 | 370,845 | SH | | SOLE | | 370,845 | 0 | 0 |
| Halozyme Therapeutics, Inc. | COM | 40637H109 | 4,653 | 299,969 | SH | | SOLE | | 299,969 | 0 | 0 |
| Harpoon Therapeutics, Inc. | COM | 41358P106 | 2,927 | 214,285 | SH | | SOLE | | 214,285 | 0 | 0 |
| Heron Therapeutics, Inc. | COM | 427746102 | 111,335 | 6,018,104 | SH | | SOLE | | 6,018,104 | 0 | 0 |
| HOOKIPA Pharma Inc. | COM | 43906K100 | 6,696 | 892,857 | SH | | SOLE | | 892,857 | 0 | 0 |
| IDEAYA Biosciences, Inc. | COM | 45166A102 | 1,800 | 200,000 | SH | | SOLE | | 200,000 | 0 | 0 |
| Idera Pharmaceuticals, Inc. | COM PAR | 45168K405 | 13,319 | 4,608,786 | SH | | SOLE | | 4,608,786 | 0 | 0 |
| IGM Biosciences, Inc. | COM | 449585108 | 55,806 | 3,144,000 | SH | | SOLE | | 3,144,000 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 | 2,373,620 | 31,976,557 | SH | | SOLE | | 31,976,557 | 0 | 0 |
| Infinity Pharmaceuticals, Inc. | COM | 45665G303 | 598 | 580,400 | SH | | SOLE | | 580,400 | 0 | 0 |
| Inflarx N.V. | COM | N44821101 | 4,393 | 1,778,415 | SH | | SOLE | | 1,778,415 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | 39,333 | 2,229,760 | SH | | SOLE | | 2,229,760 | 0 | 0 |
| Intellia Therapeutics, Inc. | COM | 45826J105 | 1,716 | 128,538 | SH | | SOLE | | 128,538 | 0 | 0 |
| Invitae Corporation | COM | 46185L103 | 169,435 | 8,792,678 | SH | | SOLE | | 8,792,678 | 0 | 0 |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | 23,824 | 2,799,577 | SH | | SOLE | | 2,799,577 | 0 | 0 |
| Kodiak Sciences Inc. | COM | 50015M109 | 131,507 | 9,145,116 | SH | | SOLE | | 9,145,116 | 0 | 0 |
| Krystal Biotech, Inc. | COM | 501147102 | 35,929 | 1,034,674 | SH | | SOLE | | 1,034,674 | 0 | 0 |
| La Jolla Pharmaceutical Company | COM PAR $.0001 2 | 503459604 | 13,721 | 1,559,231 | SH | | SOLE | | 1,559,231 | 0 | 0 |
| Leap Therapeutics, Inc. | COM | 52187K101 | 1,145 | 978,454 | SH | | SOLE | | 978,454 | 0 | 0 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 100,815 | 1,169,278 | SH | | SOLE | | 1,169,278 | 0 | 0 |
| Marker Therapeutics, Inc. | COM | 57055L107 | 7,665 | 1,500,000 | SH | | SOLE | | 1,500,000 | 0 | 0 |
| Matinas BioPharma Holdings, Inc. | COM | 576810105 | 1,252 | 1,984,965 | SH | | SOLE | | 1,984,965 | 0 | 0 |
| Menlo Therapeutics Inc. | COM | 586858102 | 3,136 | 700,000 | SH | | SOLE | | 700,000 | 0 | 0 |
| Merus N.V. | COM | N5749R100 | 20,671 | 1,160,014 | SH | | SOLE | | 1,160,014 | 0 | 0 |
| Milestone Pharmaceuticals Inc. | COM | 59935V107 | 4,973 | 266,667 | SH | | SOLE | | 266,667 | 0 | 0 |
| Mirati Therapeutics, Inc. | COM | 60468T105 | 101,846 | 1,307,220 | SH | | SOLE | | 1,307,220 | 0 | 0 |
| Mirum Pharmaceuticals, Inc. | COM | 604749101 | 3,353 | 333,333 | SH | | SOLE | | 333,333 | 0 | 0 |
| Molecular Templates, Inc. | COM | 608550109 | 1,675 | 254,230 | SH | | SOLE | | 254,230 | 0 | 0 |
| MyoKardia, Inc. | COM | 62857M105 | 79,124 | 1,517,237 | SH | | SOLE | | 1,517,237 | 0 | 0 |
| Neurocrine Biosciences, Inc. | COM | 64125C109 | 127,531 | 1,415,283 | SH | | SOLE | | 1,415,283 | 0 | 0 |
| Neurocrine Biosciences, Inc. | NOTE 2.25% 5/15/2024 | 64125CAD1 | 42,113 | 30,770,000 | PRN | | SOLE | | 30,770,000 | 0 | 0 |
| NextCure, Inc. | COM | 65343E108 | 4,628 | 150,000 | SH | | SOLE | | 150,000 | 0 | 0 |
| NGM Biopharmaceuticals, Inc. | COM | 62921N105 | 3,463 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Orchard Therapeutics plc | ADS | 68570P101 | 4,820 | 405,702 | SH | | SOLE | | 405,702 | 0 | 0 |
| Principia Biopharma Inc. | COM | 74257L108 | 46,710 | 1,654,029 | SH | | SOLE | | 1,654,029 | 0 | 0 |
| Protagonist Therapeutics, Inc. | COM | 74366E102 | 14,103 | 1,174,282 | SH | | SOLE | | 1,174,282 | 0 | 0 |
| Ra Pharmaceuticals, Inc. | COM | 74933V108 | 55,471 | 2,345,496 | SH | | SOLE | | 2,345,496 | 0 | 0 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 58,470 | 2,708,200 | SH | | SOLE | | 2,708,200 | 0 | 0 |
| Ritter Pharmaceuticals, Inc. | COM | 767836307 | 87 | 279,999 | SH | | SOLE | | 279,999 | 0 | 0 |
| Sangamo Therapeutics, Inc. | COM | 800677106 | 9,048 | 999,823 | SH | | SOLE | | 999,823 | 0 | 0 |
| Seattle Genetics, Inc. | COM | 812578102 | 4,274,891 | 50,057,277 | SH | | SOLE | | 50,057,277 | 0 | 0 |
| Sierra Oncology, Inc. | COM | 82640U107 | 781 | 2,000,000 | SH | | SOLE | | 2,000,000 | 0 | 0 |
| Spark Therapeutics, Inc. | COM | 84652J103 | 72,922 | 751,927 | SH | | SOLE | | 751,927 | 0 | 0 |
| Spring Bank Pharmaceuticals, Inc. | COM | 849431101 | 2,109 | 613,144 | SH | | SOLE | | 613,144 | 0 | 0 |
| Sunesis Pharmaceuticals, Inc. | COM | 867328700 | 401 | 556,665 | SH | | SOLE | | 556,665 | 0 | 0 |
| Syros Pharmaceuticals, Inc. | COM | 87184Q107 | 10,119 | 974,835 | SH | | SOLE | | 974,835 | 0 | 0 |
| Tricida, Inc. | COM | 89610F101 | 60,811 | 1,969,905 | SH | | SOLE | | 1,969,905 | 0 | 0 |
| Trillium Therapeutics Inc. | COM | 89620X506 | 155 | 505,262 | SH | | SOLE | | 505,262 | 0 | 0 |
| uniQure N.V. | SHS | N90064101 | 20,377 | 517,700 | SH | | SOLE | | 517,700 | 0 | 0 |
| UroGen Pharma Ltd. | COM | M96088105 | 17,819 | 747,751 | SH | | SOLE | | 747,751 | 0 | 0 |
| Viking Therapeutics, Inc. | COM | 92686J106 | 2,924 | 425,000 | SH | | SOLE | | 425,000 | 0 | 0 |
| Xbiotech Inc. | COM | 98400H102 | 5,453 | 521,327 | SH | | SOLE | | 521,327 | 0 | 0 |
| Xencor, Inc. | COM | 98401F105 | 14,440 | 428,120 | SH | | SOLE | | 428,120 | 0 | 0 |
| Y-mAbs Therapeutics, Inc. | COM | 984241109 | 2,679 | 102,800 | SH | | SOLE | | 102,800 | 0 | 0 |
| Zymeworks Inc. | COM | 98985W102 | 42,370 | 1,708,472 | SH | | SOLE | | 1,708,472 | 0 | 0 |
